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PET and SPECT of Neurobiological Systems

https://libcat.nshealth.ca/en/permalink/provcat46365
Rudi A.J.O. Dierckx, Andreas Otte, Erik F.J. de Vries, Aren van Waarde, editors ; Adriaan A. Lammertsma, guest editor. (Second edition) --Cham: Springer , c2021.
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NEW Springer 2021
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This book, now in a fully updated second edition, is a comprehensive and up-to-date guide to the use of PET and SPECT for the imaging of neurobiological systems. Diverse aspects of neurotransmission in the brain are discussed, such as visualization and quantification of neuroreceptors, neuroinflammatory markers, transporters, and enzymes as well as neurotransmitter synthesis, ß-amyloid deposition, cerebral blood flow, and the metabolic rate of glucose. The latest results in probe development ar…
Available Online
View e-Book
Other Authors
Dierckx, Rudi A.J.O.
Otte, Andreas
de Vries, Erik F.J.
van Waarde, Aren
Lammertsma, Adriaan A.
Responsibility
Rudi A.J.O. Dierckx, Andreas Otte, Erik F.J. de Vries, Aren van Waarde, editors ; Adriaan A. Lammertsma, guest editor
Edition
Second edition
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2021
Physical Description
1 online resource (xii, 1132 p.) : 374 illus., 165 illus. in color
ISBN
9783030531768
9783030531751 (Print ed.)
9783030531775 (Print ed.)
9783030531782 (Print ed.)
Subjects (MeSH)
Neurobiology - methods
Positron-Emission Tomography
Tomography, Emission-Computed, Single-Photon
Specialty
Diagnostic Imaging
Neurology
Physiology
Abstract
This book, now in a fully updated second edition, is a comprehensive and up-to-date guide to the use of PET and SPECT for the imaging of neurobiological systems. Diverse aspects of neurotransmission in the brain are discussed, such as visualization and quantification of neuroreceptors, neuroinflammatory markers, transporters, and enzymes as well as neurotransmitter synthesis, ß-amyloid deposition, cerebral blood flow, and the metabolic rate of glucose. The latest results in probe development are also detailed. A wide range of systems not addressed in the first edition are covered, reflecting the advances made in recent years. The book combines the expertise of authors internationally renowned for their dedication to the development of novel probes and techniques for the investigation of neurobiological systems. Most chapters are written jointly by radiochemists and nuclear medicine specialists to ensure a multidisciplinary approach. This state of the art compendium will be valuable to all with an interest in clinical and preclinical neuroscience. Companion volumes on the use of PET and SPECT in neurology and psychiatry complete a trilogy.
Contents
Part I. Basics -- 1. Animal Models for Brain Research -- 2. The Use of Small Animal Molecular Imaging (µPET) Exemplified in a Neurobiological Pathology -- 3. Total-Body PET -- 4. Cerebral Glucose Metabolism -- 5. Cerebral Blood Flow Measurement with Oxygen-15 Water Positron Emission Tomography -- 6. The Impact of Genetic Polymorphisms on Neuroreceptor Binding: Results from PET and SPECT Neuroreceptor Imaging Studies -- Part II. Systems -- 7. PET Imaging of Acetylcholinesterase -- 8. Imaging of Adenosine Receptors -- 9. Imaging of Central Benzodiazepine Receptors in Chronic Cerebral Ischemia -- 10. PET Imaging of Cyclooxygenases in Neuroinflammation -- 11. PET and SPECT Imaging of the Central Dopamine System in Humans -- 12. PET Imaging of the Endocannabinoid System -- 13. Current Radioligands for the PET Imaging of Metabotropic Glutamate Receptors -- 14. PET and SPECT Imaging of Steroid Hormone Receptors in the Brain -- 15. PET Imaging of Monoamine Oxidase B -- 16. Attempts to Image MRP1 Function in the Blood-Brain Barrier Using the Metabolite Extrusion Method - 17. Neuroinflammation: From Target Selection to Preclinical and Clinical Studies -- 18. Preclinical and Clinical Aspects of Nicotinic Acetylcholine Receptor Imaging -- 19. Development of PET and SPECT Radioligands for In Vivo Imaging of NMDA Receptors -- 20. Progress in PET Imaging of the Norepinephrine Transporter System -- 21. Positron Emission Tomography (PET) Imaging of Opioid Receptors -- 22. PET Imaging of ABC Transporters at the Blood-Brain Barrier -- 23. PET Imaging of Phosphodiesterases in Brain -- 24. PET Imaging of Purinergic Receptors -- 25. Imaging of the Serotonin System: Radiotracers and Applications in Memory Disorders -- 26. Monoamine Oxidase A and Serotonin Transporter Imaging with Positron Emission Tomography -- 27. PET Imaging of Sigma1 Receptors -- 28. Sigma-2 Receptors: An Emerging Target for CNS PET Imaging Studies -- 29. PET Imaging of Synaptic Vesicle Protein 2A -- 30. PET Imaging of Translocator Protein Expression in Neurological Disorders -- 31. Toward Imaging Tropomyosin Receptor Kinase (Trk) with Positron Emission Tomography -- 32. Radioligand Development for PET Imaging of the Vesicular Acetylcholine Transporter (VAChT) in the Brain -- 33. PET Imaging of Vesicular Monoamine Transporters.
Access
NEW Springer 2021
Format
e-Book
Location
Online
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