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Antiphospholipid Syndrome : Current Research Highlights and Clinical Insights

https://libcat.nshealth.ca/en/permalink/provcat41773
Doruk Erkan, Michael D. Lockshin, editors. --Cham: Springer , 2017.
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Online
This new edition is a comprehensive and updated resource on antiphospholipid syndrome (APS), which is an autoimmune disorder. In APS, the body recognizes certain normal components of blood and/or cell membranes as foreign substances and produces antibodies (antiphospholipid antibodies) against them. APS is associated with recurrent clotting events (thrombosis) including premature stroke, repeated miscarriages, phlebitis, venous thrombosis, and pulmonary thromboembolism. It is also associated wi…
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Other Authors
Erkan, Doruk
Lockshin, Michael D
Responsibility
Doruk Erkan, Michael D. Lockshin, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
2017
Physical Description
1 online resource (xx, 372 pages) : 18 illus., 16 illus. in color
ISBN
9783319554426
9783319554402 (print ed.)
Subjects (MeSH)
Antiphospholipid Syndrome
Abstract
This new edition is a comprehensive and updated resource on antiphospholipid syndrome (APS), which is an autoimmune disorder. In APS, the body recognizes certain normal components of blood and/or cell membranes as foreign substances and produces antibodies (antiphospholipid antibodies) against them. APS is associated with recurrent clotting events (thrombosis) including premature stroke, repeated miscarriages, phlebitis, venous thrombosis, and pulmonary thromboembolism. It is also associated with low platelet or blood elements that prevent bleeding. Recently, however, even more disease states have been linked with APS, including premature heart attack, various cardiac valvular abnormalities, skin lesions, kidney disease, abnormal involuntary movement/chorea, diseases that mimic multiple sclerosis, and vascular diseases of the eye that can lead to visual loss and blindness. The International Congress on Antiphospholipid Antibodies, held every 3 years, is the venue where representatives from different disciplines gather to discuss the recent advances in APS. The conference intends to cover basic aspects of APS, such as pathogenesis, origins, genetics, intracellular and molecular events, the role of infections, as well as traditional and non-traditional clinical manifestations associated with antiphospholipid antibodies. The 15th Congress took place in September 2016. A novel aspect of the Congress was that multiple teams, chaired by Scientific Planning Committee members, used evidence-based literature reviews and expert discussions to answer specific pre-defined APS-related questions. These teams included points of view from experts in rheumatology, hematology, cardiovascular medicine, obstetrics, neurology, and immunology. The Scientific Planning Committee members also chaired the congress sessions and supervised completion of the reports that are the bases of the chapters of this book. In addition, there are two chapters included specifically written for APS patients. Much like the previous volume, dedicated to the 13th International Congress on Antiphospholipid Antibodies (April 2010), this up-to-date and comprehensive work gathers invaluable insights from a multidisciplinary team of world-renowned experts and represents the authoritative resource on causes, symptoms, diagnosis, and treatment of APS.
Contents
Part I: HISTORICAL ASPECTS OF ANTIPHOSPHOLIPID SYNDROME -- History of Antiphospholipid Antibody -- Part II. BASIC SCIENCE ASPECTS OF ANTIPHOSPHOLIPID SYNDROME -- Natural Proteins Involved in Antiphospholipid Syndrome -- Origin of Antiphospholipid Antibodies -- Recent Advances in Understanding of the Genetics of Antiphospholipid Syndrome -- Mechanisms of Antiphospholipid Antibody-mediated Thrombosis -- Mechanisms of Antiphospholipid Antibody-mediated Pregnancy Morbidity -- Definition and Epidemiology of Antiphospholipid Syndrome -- Part III. CLINICAL & DIAGNOSTIC ASPECTS OF ANTIPHOSPHOLIPID SYNDROME -- Clinical and Prognostic Significance of Non-criteria Antiphospholipid Antibody Tests -- Disease and Risk Measurement Criteria in Antiphospholipid Syndrome -- Neuropsychiatric Manifestations of Antiphospholipid Syndrome -- Part IV. THERAPEUTIC ASPECTS OF ANTIPHOSPHOLIPID SYNDROME -- Prevention and Treatment of Thrombotic Antiphospholipid Syndrome -- Prevention and Treatment of Obstetric Antiphospholipid Syndrome -- Treatment of Non-criteria Manifestations in Antiphospholipid Syndrome -- Antiphospholipid Syndrome Alliance for Clinical Trials and InternatiOnal Networking (APS ACTION) -- Part V. 15th INTERNATIONAL CONGRESS ON ANTIPHOSPHOLIPID ANTIBODIES TASK FORCE REPORTS -- 15th International Congress on Antiphospholipid Antibodies - Task Force on Antiphospholipid Syndrome Classification Criteria Report -- 15th International Congress on Antiphospholipid Antibodies - Task Force on Pediatric Antiphospholipid Syndrome Report -- 15th International Congress on Antiphospholipid Antibodies - Task Force on Catastrophic Antiphospholipid Syndrome Report -- Part VI. ANTIPHOSPHOLIPID SYNDROMR FOR PATIENTS -- Antiphospholipid Syndrome: What Should Patients Know? -- Obstetric Antiphospholipid Syndrome: What Should Patients Know?
Format
e-Book
Location
Online
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Atlas of Pediatric and Youth ECG

https://libcat.nshealth.ca/en/permalink/provcat43410
Gabriele Bronzetti. --Cham: Springer , c2018.
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This book describes in detail the specific aspects of ECG during childhood and adolescence, pursuing an accessible, didactic and easy-to-read approach. Instructive, self-contained and intelligently written, it succeeds in making this diagnostic tool, the interpretation of which is especially complex in younger patients, more comprehensible, while also offering a sound and extensive reference guide for all those who diagnose young patients with electrocardiography. Though ECG produces a relative…
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Author
Bronzetti, Gabriele
Responsibility
Gabriele Bronzetti
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2018
Physical Description
1 online resource (xx, 382 p.) : 390 illus., 389 illus. in color
ISBN
9783319571027
9783319571010 (print ed.)
9783319571034 (print ed.)
9783319860770 (print ed.)
Subjects (MeSH)
Adolescent
Child
Electrocardiography
Specialty
Cardiology
Monitoring, Physiologic
Pediatrics
Abstract
This book describes in detail the specific aspects of ECG during childhood and adolescence, pursuing an accessible, didactic and easy-to-read approach. Instructive, self-contained and intelligently written, it succeeds in making this diagnostic tool, the interpretation of which is especially complex in younger patients, more comprehensible, while also offering a sound and extensive reference guide for all those who diagnose young patients with electrocardiography. Though ECG produces a relatively simple set of readings, its interpretation and diagnosis are complex. If misinterpreted, a "butterfly effect" of hidden, often neglected heart signals can lead to important and sometimes devastating consequences. Featuring an exceptionally wide range of ECG recordings and examples, the volume sheds new light on the importance of electrophysiological examinations for patients still in their developmental years and provides advice on the use of ECG in connection with recent regulations on the participation of children, adolescents and young athletes in sports. Thanks to the variety of scenarios described, from the most frequent to the most insidious, this work will appeal to a broad readership, from cardiologists and pediatricians to family physicians, anesthesiologists, doctors in sports medicine, students and nurses.
Contents
1. Introduction -- 2. Basic Concepts of Electrocardiography -- 3. The Waves During Developmental Age -- 4. Arrhythmetics and the Magic Numbers in Cardiology -- 5. ECG Metamorphosis: From the Newborn to Adulthood -- 6. Normal and Variants -- 7. Drugs, Electrolyte Abnormalities, and Metabolic Factors -- 8. Artifacts and Devices -- 9. Bradycardias and Conduction Disorders -- 10. Pre-excitation Syndromes -- 11. Supraventricular Tachycardia -- 12. Ventricular Arrhythmias -- 13 Cardiomyopathies and Myocarditis -- 14. Cardiac Tumors and Pericardial Disease -- 15. Pulmonary Hypertension and Acquired Valvular Disease -- 16. Channelopathies -- 17. Ischemic Disease -- 18. Congenital Heart Disease -- 19. The Athlete’s Heart -- 20. Conclusions.
Format
e-Book
Publication Type
Atlas
Location
Online
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The Essential Guide to Lithium Treatment

https://libcat.nshealth.ca/en/permalink/provcat40189
Michael Bauer, Michael Gitlin. --Cham: Springer , c2016.
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This book is a practical, up-to-date guide to the correct use of lithium for the short- and long-term treatment of mood disorders. Among the subjects addressed are the pharmacology and mechanisms of action of lithium, its use for maintenance treatment, the role of lithium in the treatment of mania and depression and in suicide prevention, further clinical indications, the administration of lithium during pregnancy and the postpartum period, and adverse effects and their management. Relevant bac…
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Author
Bauer, Michael
Other Authors
Gitlin, Michael
Responsibility
Michael Bauer, Michael Gitlin
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2016
Physical Description
1 online resource (xiv, 158 p. : 17 illus., 15 illus. in color)
ISBN
9783319312149
9783319312125 (print ed.)
Subjects (MeSH)
Lithium Compounds - therapeutic use
Mood Disorders - drug therapy
Abstract
This book is a practical, up-to-date guide to the correct use of lithium for the short- and long-term treatment of mood disorders. Among the subjects addressed are the pharmacology and mechanisms of action of lithium, its use for maintenance treatment, the role of lithium in the treatment of mania and depression and in suicide prevention, further clinical indications, the administration of lithium during pregnancy and the postpartum period, and adverse effects and their management. Relevant background information is provided on the diagnosis, classification, and natural course of mood disorders, and an overview of other treatments for bipolar disorder and major depression is included. Lithium is the essential medication for patients with mood disorders. The evidence of its efficacy in maintenance treatment is acknowledged in all major international treatment guidelines for bipolar disorders and, when used correctly, lithium unquestionably produces the most dramatic benefits of any medication in psychopharmacology. This essential guide is written by two international experts in the treatment of mood disorders who have more than 25 years of experience in the use of lithium and have authored numerous scientific articles on lithium.
Contents
1. Diagnosis and Classification of Mood Disorders -- 2. Natural Course of Bipolar Disorder and Implications for Treatment -- 3. Lithium and Its History -- 4. What Is Lithium and How Does It Work? -- 5. Maintenance Treatment with Lithium -- 6. Treatment of Mania with Lithium -- 7. Treatment of Depression with Lithium -- 8. Suicide Prevention with Lithium -- 9. Neuroprotection and Other Clinical Indications of Lithium -- 10. Lithium During Pregnancy and in the Postpartum Period -- 11. Practical Management of Lithium -- 12. Adverse Effects of Lithium and Their Management -- 13. Beyond Lithium: Other Treatments for Bipolar Disorder.
Format
e-Book
Location
Online
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The Highly Sensitized Patient Program (HSP) for kidney transplant patients

https://libcat.nshealth.ca/en/permalink/chpams36746
Nova Scotia Health Authority. Central Zone. Multi-Organ Transplant Program. Halifax, NS: Nova Scotia Health Authority , 2020.
Pamphlet Number
2132
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One of the ways that your body protects itself from infection is by destroying cells it does not recognize as its own. When your body does not recognize a cell, it produces an antibody. Antibodies destroy infections and transplanted tissues (like in a kidney transplant). A highly sensitized patient has a high percentage of antibodies. These antibodies make them more likely to reject an organ after transplant. This pamphlet explains how to know if you are sensitized, what the Highly Sensitized P…
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Corporate Author
Nova Scotia Health Authority. Central Zone. Multi-Organ Transplant Program
Place of Publication
Halifax, NS
Publisher
Nova Scotia Health Authority
Date of Publication
2020
Format
Pamphlet
Language
English
Physical Description
1 electronic document (6 p.) : digital, PDF file
Subjects (MeSH)
Kidney transplantation
Subjects (LCSH)
Kidneys--Transplantation
Specialty
Nephrology
Abstract
One of the ways that your body protects itself from infection is by destroying cells it does not recognize as its own. When your body does not recognize a cell, it produces an antibody. Antibodies destroy infections and transplanted tissues (like in a kidney transplant). A highly sensitized patient has a high percentage of antibodies. These antibodies make them more likely to reject an organ after transplant. This pamphlet explains how to know if you are sensitized, what the Highly Sensitized Patient Program is, how the program increases your chance of finding a match, what happens if there is a possible match for you, and what you can do to increase your chances of getting a transplant. A list of resources is included.
Responsibility
Prepared by: Multi-Organ Transplant Program
Pamphlet Number
2132
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Imaging coronary arteries

https://libcat.nshealth.ca/en/permalink/provcat33543
David A. Dowe, Massimo Fioranelli, Paolo Pavone, editors ; in collaboration with Roberto Leo. --Milan: Springer , c2013.
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Online
Cardiovascular diseases are the leading cause of death in Western countries. In non-fatal cases, they are associated with a decreased quality of life as well as a substantial economic burden to society. Most sudden cardiac events are related to the complications of a non-stenosing marginal plaque. For this reason, the ability to properly identify the atherosclerotic plaque with rapid, non-invasive techniques is of utmost clinical interest in therapeutic planning. CT produces high-quality images…
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Other Authors
Dowe, David A
Fioranelli, Massimo
Pavone, P
Leo, Roberto
Responsibility
David A. Dowe, Massimo Fioranelli, Paolo Pavone, editors ; in collaboration with Roberto Leo
Former Title
CT evaluation of coronary artery disease
Place of Publication
Milan
Publisher
Springer
Date of Publication
c2013
Physical Description
1 online resource (xii, 261 pages)
ISBN
9788847026827 (electronic bk.)
9788847026810
Subjects (MeSH)
Coronary Angiography
Coronary Artery Disease - diagnosis
Subjects (LCSH)
Coronary arteries - Radiography
Tomography
Coronary Artery Disease - diagnosis
Coronary Angiography
Notes
"With a collection of clinical cases."
Revised edition of: CT evaluation of coronary artery disease / Paolo Pavone, Massimo Fioranelli, David A. Dowe, c2009.
Abstract
Cardiovascular diseases are the leading cause of death in Western countries. In non-fatal cases, they are associated with a decreased quality of life as well as a substantial economic burden to society. Most sudden cardiac events are related to the complications of a non-stenosing marginal plaque. For this reason, the ability to properly identify the atherosclerotic plaque with rapid, non-invasive techniques is of utmost clinical interest in therapeutic planning. CT produces high-quality images of the coronary arteries, in addition to defining their location and the extent of the atherosclerotic involvement. Proper knowledge of the equipment, adequate preparation of the patient, and accurate evaluation of the images are essential to obtaining a consistent clinical diagnosis in every case. This new edition is enriched with dedicated chapters on intravascular ultrasound (IVUS), catheter angiography, and nuclear imaging, with limited discussions of theoretical techniques such as optical coherence tomography (OCT) and magnetic resonance imaging (MRI). Brief chapters will also be included that discuss percutaneous coronary artery procedures and coronary artery bypass surgery. Indications of when to use CCTA will be discussed, with comparison of these imaging techniques to each other. This volume provides general practitioners and cardiologists with a basic understanding of the imaging techniques. For radiologists with no direct experience in cardiac imaging, the book serves as an important source of information on coronary pathophysiology and anatomy.
Contents
Clinical anatomy of the coronary circulation -- Basic techniques in the acquisition of cardiac images with CT -- CT examination of the coronary arteries -- Image reconstruction -- Coronary pathophysiology -- Clinical classification of coronary artery disease : who should be treated? -- Intravascular ultrasound : from gray-scale to virtual histology -- Identification and characterization of the atherosclerotic plaque using coronary CT angiography -- Coronary CT angiography : evaluation of stenosis and occlusion -- Current strategies in cardiac surgery -- Coronary CT angiography : evaluation of coronary artery bypass grafts -- Coronary stents -- CT angiography of coronary stents -- X-ray exposure in coronary CT angiography -- Optical coherence tomography in the cathlab -- Triple rule out : the use of cardiac CT in the emergency room -- Contraindications to coronary CT angiography -- Prognostic value of coronary CT -- Clinical cases.
Format
e-Book
Location
Online
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Managing patient dose in digital radiology

https://libcat.nshealth.ca/en/permalink/provcat44704
editor, J. Valentin. --Oxford, England: Elsevier , 2004.
Call Number
WN 160 I15i 2004
Location
Dickson Building
Digital techniques have the potential to improve the practice of radiology but they also risk the overuse of radiation. The main advantages of digital imaging, i.e. wide dynamic range, post processing, multiple viewing options, and electronic transfer and archiving possibilities, are clear but overexposures can occur without an adverse impact on image quality. In conventional radiography, excessive exposure produces a 'black' film. In digital systems, good images are obtained for a large range …
Call Number
WN 160 I15i 2004
Corporate Author
International Commission on Radiological Protection
Other Authors
Valentin, J
Responsibility
editor, J. Valentin
Place of Publication
Oxford, England
Publisher
Elsevier
Date of Publication
2004
Physical Description
73 p.
Series Vol.
93
Series Title
ICRP publication
ISBN
0080444695
Subjects (MeSH)
Body Burden
Radiation Dosage
Radiation Injuries - prevention & control
Radiation Protection
Radiometry
Safety Management
Specialty
Radiotherapy
Notes
Published as: Annals of the ICRP v. 34, n. 1, 2004.
Abstract
Digital techniques have the potential to improve the practice of radiology but they also risk the overuse of radiation. The main advantages of digital imaging, i.e. wide dynamic range, post processing, multiple viewing options, and electronic transfer and archiving possibilities, are clear but overexposures can occur without an adverse impact on image quality. In conventional radiography, excessive exposure produces a 'black' film. In digital systems, good images are obtained for a large range of doses. It is very easy to obtain (and delete) images with digital fluoroscopy systems, and there may be a tendency to obtain more images than necessary. In digital radiology, higher patient dose usually means improved image quality, so a tendency to use higher patient doses than necessary could occur. Different medical imaging tasks require different levels of image quality, and doses that have no additional benefit for the clinical purpose should be avoided. Image quality can be compromised by inappropriate levels of data compression and/or postprocessing techniques. All these new challenges should be part of the optimisation process and should be included in clinical and technical protocols. Local diagnostic reference levels should be re-evaluated for digital imaging, and patient dose parameters should be displayed at the operator console. Frequent patient dose audits should occur when digital techniques are introduced. Training in the management of image quality and patient dose in digital radiology is necessary. Digital radiology will involve new regulations and invoke new challenges for practitioners. As digital images are easier to obtain and transmit, the justification criteria should be reinforced. Commissioning of digital systems should involve clinical specialists, medical physicists, and radiographers to ensure that imaging capability and radiation dose management are integrated. Quality control requires new procedures and protocols (visualisation, transmission, and archiving of the images).
Format
Book
Publication Type
Practice Guideline
Location
Dickson Building
Loan Period
3 weeks
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Mental Health and Social Issues Following a Nuclear Accident : The Case of Fukushima

https://libcat.nshealth.ca/en/permalink/provcat40401
Jun Shigemura, Rethy Kieth Chhem, editors. (1st ed.) --Tokyo: Springer Japan , c2016.
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Location
Online
This book focuses on mental health issues arising in the wake of the Fukushima nuclear disaster. Three years after the 11 March 2011 Great East Japan Earthquake, tsunamis, and Fukushima Daiichi nuclear accident, roughly 130,000 individuals continue to face enormous burdens as a result of mandatory evacuation. Many evacuees still live in temporary housing, and returning home remains a distant dream as they wait for the decontamination of the danger zone to be completed. However, the plant recove…
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Other Authors
Shigemura, Jun
Chhem, Rethy Kieth
Responsibility
Jun Shigemura, Rethy Kieth Chhem, editors
Edition
1st ed.
Place of Publication
Tokyo
Publisher
Springer Japan
Date of Publication
c2016
Physical Description
1 online resource (xxi, 130 p. : 20 illus.)
ISBN
9784431556992
9784431556985 (print ed.)
Subjects (MeSH)
Adaptation, Psychological
Disaster Medicine - methods
Fukushima Nuclear Accident
Mental health
Resilience, Psychological
Social Support
Other Subjects
Japan
Abstract
This book focuses on mental health issues arising in the wake of the Fukushima nuclear disaster. Three years after the 11 March 2011 Great East Japan Earthquake, tsunamis, and Fukushima Daiichi nuclear accident, roughly 130,000 individuals continue to face enormous burdens as a result of mandatory evacuation. Many evacuees still live in temporary housing, and returning home remains a distant dream as they wait for the decontamination of the danger zone to be completed. However, the plant recovery process is still evolving, and the complete cleanup will take decades. Beyond all of these hardships, many evacuees are also mourning the loss of their loved ones. The compound disaster with its many uncertainties poses and will continue to pose serious emotional and social challenges. People affected by the nuclear disaster have been facing serious psychological challenges from ongoing fear of radiation exposure. Furthermore, there is continuing debate between various stakeholders on the options for disaster responses. This situation in turn produces adverse public responses, such as discrimination and stigmatization of the evacuees and scapegoating of the authorities and nuclear plant workers. Mental Health and Social Issues Following a Nuclear Accident addresses these issues and their impacts, pursuing both evidence-based and narrative-based approaches. It also contrasts the Fukushima findings with those of other nuclear disasters, namely, Three Mile Island and Chernobyl.
Contents
1. Godzilla mon amour: the Origins and Legacy of Nuclear Fear in Japan -- 2. Unforeseeable Accidents from the Point of View of the Legal System -- 3. Report on Fukushima Counseling Support Professional Team: Interdisciplinary Team Approach for Psychosocial Care of Evacuees -- 4. Societal and Ethical Aspects of Radiation Risk Perception -- 5. Thinking Across Disaster -- 6. Emotional Consequences of TMI and Chernobyl: Lessons Learned for Fukushima -- 7. 3/11 and 9/11: A Multi-faceted Investigation of a Survivor Exchange Program -- 8. Psychosocial Responses to Disaster and Exposures: Distress Reactions, Health Risk Behavior, and Mental Disorders -- 9. Psychosocial Challenges of the Fukushima Nuclear Plant Workers.
Format
e-Book
Location
Online
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Physiology and physiopathology of adipose tissue

https://libcat.nshealth.ca/en/permalink/provcat32475
Jean-Philippe Bastard, Bruno Fève, editors. --Paris: Springer , c2013.
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Location
Online
The scientific advances in the physiology and pathophysiology of adipose tissue over the last two decades have been considerable. Today, the cellular and molecular mechanisms of adipogenesis are well known. In addition, adipose tissue is now recognized as a real endocrine organ that produces hormones such as the leptin acting to regulate food intake and energy balance in the central nervous system, a finding that has completely revolutionized the paradigm of energy homeostasis. Other adipokines…
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Other Authors
Bastard, Jean-Philippe
Fève, Bruno
Responsibility
Jean-Philippe Bastard, Bruno Fève, editors
Place of Publication
Paris
Publisher
Springer
Date of Publication
c2013
Physical Description
1 online resource (xix, 437 p. : 51 ill. in color)
ISBN
9782817803432
Subjects (MeSH)
Adipose Tissue - physiology
Adipose Tissue - physiopathology
Obesity - physiopathology
Subjects (LCSH)
Endocrinology 
Metabolic diseases
Lipids
Abstract
The scientific advances in the physiology and pathophysiology of adipose tissue over the last two decades have been considerable. Today, the cellular and molecular mechanisms of adipogenesis are well known. In addition, adipose tissue is now recognized as a real endocrine organ that produces hormones such as the leptin acting to regulate food intake and energy balance in the central nervous system, a finding that has completely revolutionized the paradigm of energy homeostasis. Other adipokines have now been described and these molecules are taking on increasing importance in physiology and pathophysiology. Moreover, numerous works have shown that in obesity, but also in cases of lipodystophy, adipose tissue was the site of a local low-grade inflammation that involves immune cells such as macrophages and certain populations of lymphocytes. This new information is an important step in the pathophysiology of both obesity and related metabolic and cardiovascular complications. Finally, it is a unique and original work focusing on adipose tissue, covering biology and pathology by investigating aspects of molecular and cellular biology, general, metabolic, genetic and genomic biochemistry.
Contents
Foreword -- Part I: Adipose tissue development -- 1. Development of adipose cells -- 2. Emerging roles of cell cycle regulators in adipocyte metabolism -- 3. Angiogenesis in adipose tissue -- 4. Prospects for using adipose tissue in regenerative medicine -- 5. Brown adipose tissue: function and development -- 6. Histology of adipose tissue -- Part II: Adipose tissue metabolic functions -- 7. Glucose transport in white adipocyte -- 8. Mechanism of storage and synthesis of fatty acids and triglycerides in white adipocytes -- 9. Adipocyte lipid droplet physiology -- 10. Adipose tissue lipolysis -- 11. The adipose tissue: storage, source and target of pollutants -- Part III: Endocrine functions of adipocyte -- 12. Chatting between the brain and white adipose tissues -- 13. Adiponectin: an adipokine with multiple faces -- 14. Apelin metabolic functions -- 15. Up-to-date on novel "adipocrines" -- Part IV: Pathology of adipose tissue -- 16. Obesity: an evolving process -- 17. Obesity phenotypes : Measures to assess adipose tissue mass in humans -- 18. Animal models of obesity -- 19. Contribution of "omics" approaches to understand the pathophysiology of obesity -- 20. Adipose tissue inflammation in obesity -- 21. Impact of proinflammatory cytokines on adipocyte insulin signaling -- 22. Adaptive changes in human adipose tissue during weight gain -- 23. Differences between subcutaneous and visceral adipose tissues -- 24. Genetics of human obesities -- 25. Genetic and acquired lipodystrophic syndromes -- 26. Is adipose tissue a relevant therapeutic target of obesity? -- Index.
Format
e-Book
Location
Online
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Post-Traumatic Stress Disorder : A Guide for Primary Care Clinicians and Therapists

https://libcat.nshealth.ca/en/permalink/provcat46357
J.F. Pagel. --Cham: Springer , c2021.
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Access
NEW Springer 2021
Location
Online
PTSD is in no way an easy diagnosis for the patient, the provider, or the therapist. It is a diagnosis developed at the border of our capacity to handle extreme stress, a marker diagnosis denoting the limits of our capacity for functioning in the stress of this modern world. For both individuals and society, PTSD marks the limits of our available compassion and our capacity to protect ourselves from the dangers of the environment and other humans. PTSD is often a chronic disease, forming at a p…
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Author
Pagel, J.F.
Responsibility
J.F. Pagel.
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2021
Physical Description
1 online resource (xiii, 165 p.) : 17 illus., 6 illus. in color
ISBN
9783030559090
9783030559083 (Print ed.)
9783030559106 (Print ed.)
Subjects (MeSH)
Stress Disorders, Post-Traumatic - diagnosis
Stress Disorders, Post-Traumatic - therapy
Specialty
Psychiatry
Psychotherapy
Abstract
PTSD is in no way an easy diagnosis for the patient, the provider, or the therapist. It is a diagnosis developed at the border of our capacity to handle extreme stress, a marker diagnosis denoting the limits of our capacity for functioning in the stress of this modern world. For both individuals and society, PTSD marks the limits of our available compassion and our capacity to protect ourselves from the dangers of the environment and other humans. PTSD is often a chronic disease, forming at a place where mind sometimes no longer equals the brain, a point at which individual patient requirements often trump theory and belief. There are treatments for PTSD that work, and many that do not. This book presents evidence, rather than theory, anecdote, or case report. Psychological approaches including prolonged exposure, imagery rehearsal therapy and EMDR have a greater than 75% positive short-term response when used to treat PTSD. Yet these treatments vary markedly and have different, even contradictory underlying theory and objectives for treatment. Medications, rarely indicated as primary therapy, can be used to treat symptoms and address comorbid PTSD diagnoses. Treatment of sleep apnea in the PTSD population produces a positive effect on symptoms and a reduction in morbidity and mortality across the span of life. Complementary treatments offer the many individuals chronically affected by PTSD assistance in coping with symptoms and opportunities to attempt to functionally integrate their experience of trauma.
Contents
1. Shell shock and society -- 2. Unzipping PTSD: criteria and screeners -- 3. Disasters and societal trauma: complex and societal PTSD -- 4. The origins of PTSD: psychodynamic trauma and the human stress response -- 5. Nightmare science -- 6. Chronic PTSD -- 7. Treating the emergency: acute trauma -- 8. Classic psychotherapy for PTSD -- 9. Group therapy for PTSD -- 10. Classic cognitive behavioral therapy -- 11. Prolonged exposure therapy -- 12. Eye movement desensitization and processing (EMDR) -- 13. Imagery rehearsal therapy -- 14. Ptsd: the medications -- 15. Sleep apnea and PTSD -- 16. Complementary approaches to healing PTSD: art, body, and mind awareness -- 17. When treatment doesn't work -- 18. An evidence-based approach to PTSD therapy.
Access
NEW Springer 2021
Format
e-Book
Location
Online
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Secondary Analysis of Electronic Health Records

https://libcat.nshealth.ca/en/permalink/provcat40325
MIT Critical Data. --Cham: Springer , c2016.
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Access
Open access
Location
Online
This book trains the next generation of scientists representing different disciplines to leverage the data generated during routine patient care. It formulates a more complete lexicon of evidence-based recommendations and support shared, ethical decision making by doctors with their patients. Diagnostic and therapeutic technologies continue to evolve rapidly, and both individual practitioners and clinical teams face increasingly complex ethical decisions. Unfortunately, the current state of med…
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Corporate Author
MIT Critical Data
Responsibility
MIT Critical Data
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2016
Physical Description
1 online resource (xxi, 427 p. : 108 illus., 100 illus. in color)
ISBN
9783319437422
9783319437408 (print ed.)
Subjects (MeSH)
Data Anonymization
Data Curation
Electronic Health Records
Quality Control
Specialty
Health Services Research
Medical Informatics
Abstract
This book trains the next generation of scientists representing different disciplines to leverage the data generated during routine patient care. It formulates a more complete lexicon of evidence-based recommendations and support shared, ethical decision making by doctors with their patients. Diagnostic and therapeutic technologies continue to evolve rapidly, and both individual practitioners and clinical teams face increasingly complex ethical decisions. Unfortunately, the current state of medical knowledge does not provide the guidance to make the majority of clinical decisions on the basis of evidence. The present research infrastructure is inefficient and frequently produces unreliable results that cannot be replicated. Even randomized controlled trials (RCTs), the traditional gold standards of the research reliability hierarchy, are not without limitations. They can be costly, labor intensive, and slow, and can return results that are seldom generalizable to every patient population. Furthermore, many pertinent but unresolved clinical and medical systems issues do not seem to have attracted the interest of the research enterprise, which has come to focus instead on cellular and molecular investigations and single-agent (e.g., a drug or device) effects. For clinicians, the end result is a bit of a "data desert" when it comes to making decisions. The new research infrastructure proposed in this book will help the medical profession to make ethically sound and well informed decisions for their patients.
Contents
Part I. Setting the Stage: Rationale Behind and Challenges to Health Data Analysis -- 1. Objectives of the Secondary Analysis of Electronic Health Record Data -- 2. Review of Clinical Databases -- 3. Challenges and Opportunities in Secondary Analyses of Electronic Health Record Data -- 4. Pulling It All Together: Envisioning a Data-Driven, Ideal Care System -- 5. The Story of MIMIC -- 6. Integrating Non-clinical Data with EHRs -- 7. Using EHR to Conduct Outcome and Health Services Research -- 8. Residual Confounding Lurking in Big Data: A Source of Error -- Part II. A Cookbook: From Research Question Formulation to Validation of Findings -- 9. Formulating the Research Question -- 10. Defining the Patient Cohort -- 11. Data Preparation -- 12. Data Pre-processing -- 13. Missing Data -- 14. Noise Versus Outliers -- 15. Exploratory Data Analysis -- 16. Data Analysis -- 17. Sensitivity Analysis and Model Validation -- Part III. Case Studies Using MIMIC -- 18. Trend Analysis: Evolution of Tidal Volume Over Time for Patients Receiving Invasive Mechanical Ventilation -- 19. Instrumental Variable Analysis of Electronic Health Records -- 20. Mortality Prediction in the ICU Based on MIMIC-II Results from the Super ICU Learner Algorithm (SICULA) Project -- 21. Mortality Prediction in the ICU -- 22. Data Fusion Techniques for Early Warning of Clinical Deterioration -- 23. Comparative Effectiveness: Propensity Score Analysis -- 24. Markov Models and Cost Effectiveness Analysis: Applications in Medical Research -- 25. Blood Pressure and the Risk of Acute Kidney Injury in the ICU: Case-Control Versus Case-Crossover Designs -- 26. Waveform Analysis to Estimate Respiratory Rate -- 27. Signal Processing: False Alarm Reduction -- 28. Improving Patient Cohort Identification Using Natural Language Processing -- 29. Hyperparameter Selection.
Access
Open access
Format
e-Book
Location
Online
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Stress and Orality : New Data About Teeth Clenching & Outcomes, Migraine, Fibromyalgia, Fatigue

https://libcat.nshealth.ca/en/permalink/provcat39617
Francis Hartmann, Gérard Cucchi. --Paris: Springer , c2014.
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Location
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"The reading of STRESS and ORALITY written by F. HARTMANN and G. CUCCHI led me to believe that we should consider the problem of certain migraines, neck pain, fibromyalgia, and chronic fatigue from a radically different angle than the historically traditional approach." Roger Guillemin (Nobel Laureate in Medicine) Are oral disorders only an issue for dentists? The answer is no. If your patients complain of pain and/or discomfort, if some are diagnosed as suffering from migraines, fibromyalgia o…
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Author
Hartmann, Francis
Other Authors
Cucchi, Gérard
Responsibility
Francis Hartmann, Gérard Cucchi
Place of Publication
Paris
Publisher
Springer
Date of Publication
c2014
Physical Description
1 online resource (xii, 300 p. : 213 illus., 212 illus. in color)
ISBN
9782817802718
9782817802701 (print ed.)
Subjects (MeSH)
Bruxism - complications
Bruxism - diagnosis
Bruxism - therapy
Pain, Referred
Stress, Psychological - complications
Temporomandibular Joint Dysfunction Syndrome - complications
Abstract
"The reading of STRESS and ORALITY written by F. HARTMANN and G. CUCCHI led me to believe that we should consider the problem of certain migraines, neck pain, fibromyalgia, and chronic fatigue from a radically different angle than the historically traditional approach." Roger Guillemin (Nobel Laureate in Medicine) Are oral disorders only an issue for dentists? The answer is no. If your patients complain of pain and/or discomfort, if some are diagnosed as suffering from migraines, fibromyalgia or chronic fatigue, and if classical therapies have remained ineffective, this book could help in your daily practice. When it comes to the complex pathology called Temporo-Mandibular Disorders (TMD) most specialists favour a multidisciplinary approach and treatment of socio-psycho-emotional factors as well as dental, lingual or postural disorders. Yet little is known - from a clinical point of view - about a tricky oral spastic habit called severe teeth clenching. In view of the lack of clinical findings from classical investigations on the subject, it could be considered as the "hidden part of an oral parafunctional iceberg". Neuroscience has been able to shed some light on the multiple connections between trigeminal and non-trigeminal nervous centres, which confirms the significant involvement of the stomatognathic system and trigeminal nerves (V) in both oral as well as non-oral major functions such as eating, breathing, speaking, hearing, and standing, and also confirms the extensive participation of the paired Vs in the human adaptation process. Too many physicians are still reluctant to admit the pathological responsibilities of the Vs. Therefore their role remains largely underestimated by clinicians. Stress conditions in introverted people cause a parafunctional habit (i.e. severe clenching), which in turn produces trigeminal overstimulation and nociception. Through a process of sensitization this can perturb some non-trigeminal nervous areas, such as the vestibular nuclei and cerebellum (involved in equilibrium). Would you then be willing to accept the possibility that a stressed and introverted patient who clenches hard, durably or frequently may end up suffering from dizziness? If not, this book is not for you. But if you accept the scientific data and clinical facts this book will offer a concrete therapeutic protocol: the Relaxing and Moderating Treatment (RMT), which can greatly help you to familiarize yourself with and neutralize this little known deleterious spastic oral parafunction and its many disconcerting pain-causing and dysfunctional clinical effects. Prepare to be amazed by the results, just as we were!
Contents
Part I. Diagnosis -- Introduction -- Symptoms -- Objective Signs -- Stomatognathic Parafunctions -- In Conclusion -- Part II. Pathophysiology -- Introduction -- Characteristics of Periodontal Proprioception -- The Trigeminal Nerve Pathways and Their Central Projections -- Useful Physiological Reminders -- Pathophysiological -- The Behavioral Side of Clenching -- Painful Outcomes of Parafunctional Clenching -- Discomfort as the Outcome of Parafunctional Clenching -- In Conclusion -- Part III. Therapeutics -- Introduction -- The Relaxing and Moderating Treatment (RMT) -- In Conclusion -- Part IV. Medical Prospects -- Medical Prospects -- General Synthesis.
Format
e-Book
Location
Online
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Vertigo and balance disorders in children

https://libcat.nshealth.ca/en/permalink/provcat33324
Kimitaka Kaga. --Tokyo: Springer , c2014.
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Location
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Many congenitally deaf infants and children suffer vestibular failure, which produces problems with their postural control, locomotion, and gait. However it is known that these children can eventually catch up with their normal balance control status in terms of development and growth as a result of central vestibular compensation. In Vertigo and Balance Disorders in Children the author provides comprehensive and integrative information on the vestibular system. The materials presented range fr…
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Author
Kaga, Kimitaka
Responsibility
Kimitaka Kaga
Place of Publication
Tokyo
Publisher
Springer
Date of Publication
c2014
Physical Description
1 online resource (ix, 86 pages)
Series Title
Modern otology and neurotology
ISBN
9784431547617 (electronic bk.)
9784431547600
Subjects (MeSH)
Postural Balance
Sensation Disorders
Vertigo
Subjects (LCSH)
Pediatric neurology
Vertigo
Vestibular apparatus - Diseases
Otorhinolaryngology
Neurology
Pediatrics
Rehabilitation Medicine
Abstract
Many congenitally deaf infants and children suffer vestibular failure, which produces problems with their postural control, locomotion, and gait. However it is known that these children can eventually catch up with their normal balance control status in terms of development and growth as a result of central vestibular compensation. In Vertigo and Balance Disorders in Children the author provides comprehensive and integrative information on the vestibular system. The materials presented range from the history of its study, basic anatomy and physiology of vestibular organs, and the mechanism of balance and motor function development, to clinical aspects of vestibular disorders including their evaluation and pediatric neurology. Although there have been books discussing postural responses of infants and children with vestibular disorders, this is the first to present the influence of peripheral vestibular disorders and central vestibular compensation comprehensively. This book will benefit not only practitioners in this field such as pediatric otolaryngologists, pediatricians, and neurologists treating both children and adults, but also clinical specialists such as neonatologists, physical therapists, and speech therapists, helping them to better care for patients with vestibular failure.
Contents
1. Introduction: History -- 2. The Basis of Vertigo and Balance Disorders in Children -- 3. Disequilibrium: Abnormal Posture Control -- 4. Vertigo in Children -- 5. Rehabilitation of Children with Disequilibrium -- 6. Inner Ear Anomalies and Vestibular-Evoked Myogenic Potentials (VEMP) -- 7. Gene Mutation in Congenital Deafness and Vestibular Failure.
Format
e-Book
Location
Online
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