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ACEi and ARBS in Hypertension and Heart Failure

https://libcat.nshealth.ca/en/permalink/provcat39106
Pasquale Perrone Filardi, editor. --Cham: Springer International Publishing : Imprint: Springer ; ISCP , c2015.
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This book summarizes how the renin angiotensin system is implicated in the progression of atherosclerotic disease as well as of left ventricular dysfunction and reviews the action of angiotensin converting enzyme inhibitors and AT1 receptor antagonists on reducing morbidity and mortality in patients with left ventricular dysfunction or in those at high cardiovascular risk with preserved ventricular function. ACEi and ARBS in Hypertension and Heart Failure is a highly practical reference reviewi…
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Other Authors
Perrone Filardi, Pasquale
Other Authors
International Society of Cardiovascular Pharmacotherapy
Responsibility
Pasquale Perrone Filardi, editor
Alternate Title
Angiotensin converting enzyme inhibitors and angiotensin II receptor blockers in hypertension and heart failure
Place of Publication
Cham
Publisher
Springer International Publishing : Imprint: Springer ; ISCP
Date of Publication
c2015
Physical Description
1 online resource (x, 150 p. : 19 illus., 13 illus. in color)
Series Title
Current cardiovascular therapy
ISBN
9783319097886
9783319097879 (print ed.)
Subjects (MeSH)
Angiotensin II Type 1 Receptor Blockers
Angiotensin-Converting Enzyme Inhibitors - pharmacology
Heart Failure - drug therapy
Hypertension - drug therapy
Renin-Angiotensin System
Abstract
This book summarizes how the renin angiotensin system is implicated in the progression of atherosclerotic disease as well as of left ventricular dysfunction and reviews the action of angiotensin converting enzyme inhibitors and AT1 receptor antagonists on reducing morbidity and mortality in patients with left ventricular dysfunction or in those at high cardiovascular risk with preserved ventricular function. ACEi and ARBS in Hypertension and Heart Failure is a highly practical reference reviewing the evidence and providing a rationale for the appropriate use of RAS antagonists in cardiovascular diseases. It is written in an easy-to-follow format and with many illustrations to aid clarity and the assimilation of information. Each chapter is written by established authorities in their fields who are also experienced in explaining often complex concepts. The result is a unique book which is not only comprehensive but also clear and useful for the busy medical practitioner.
Contents
1. Angiotensin Converting Enzyme Inhibitors and AT1 Antagonists for Treatment of Hypertension -- 2. ACE Inhibitor and Renin–Angiotensin System the Cornerstone of Therapy for Systolic Heart Failure -- 3. Impact of Chronic Kidney Disease and Diabetes Mellitus on Choice of Renin Angiotensin System: Inhibitors in Patients with Hypertension and Heart Failure -- 4. Target Organ Damage and RAAS Blockade.
Format
e-Book
Location
Online
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Aging and heart failure : mechanisms and management

https://libcat.nshealth.ca/en/permalink/provcat33590
Bodh I. Jugdutt, editor. --New York: Springer , c2014.
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This book synthesizes the major research advances in molecular, biochemical, and translational aspects of aging and heart failure over the last four decades and addresses future directions in management and drug discovery. It presents clinical issues and molecular mechanisms related to heart failure, including the changing demographics in the aging population with heart failure; hypertension and prevention of diastolic heart failure in the aging population; polypharmacy and adverse drug reactio…
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Other Authors
Jugdutt, Bodh I
Responsibility
Bodh I. Jugdutt, editor
Place of Publication
New York
Publisher
Springer
Date of Publication
c2014
Physical Description
1 online resource
ISBN
9781493902682 (electronic bk.)
9781493902675
Subjects (MeSH)
Aging - physiology
Heart Failure
Subjects (LCSH)
Heart failure
Older people - Medical care
Abstract
This book synthesizes the major research advances in molecular, biochemical, and translational aspects of aging and heart failure over the last four decades and addresses future directions in management and drug discovery. It presents clinical issues and molecular mechanisms related to heart failure, including the changing demographics in the aging population with heart failure; hypertension and prevention of diastolic heart failure in the aging population; polypharmacy and adverse drug reactions in the aging population with heart failure; changes in the heart that accompany advancing age from humans to molecules; aging-associated alterations in myocardial inflammation and fibrosis; and aging-related changes in mitochondrial function and implications for heart failure therapy. The book succinctly summarizes the large volume of data on these key topics and highlights novel pathways that need to be explored. Featuring contributions from leading clinician-scientists, Aging and Heart Failure: Mechanisms and Management is an authoritative resource on the major clinical issues in heart failure therapy in the elderly for cardiologists, gerontologists, and internists.
Contents
Changing Demographics of the Aging Population with Heart Failure and Implications for Therapy -- Biology of Aging and Implications for Heart Failure Therapy and Prevention -- Hypertension and Prevention of Diastolic Heart Failure in the Aging Population -- Aging and Optimal Therapy of Systolic Heart Failure in the Elderly -- Atrial Fibrillation and Heart Failure in the Aging Population -- Optimizing Therapy of Heart Failure in the Aging Population with Monitoring in Clinics -- Cardiac Alterations in Aging, Hypertension, and Diastolic Heart Failure -- Polypharmacy and Adverse Drug Reactions in the Aging Population with Heart Failure -- Age-Related Changes in Vascular Biology and Implications for Heart Failure Therapy in the Aging Population -- Biomarkers and Optimal Management of Heart Failure in the Aging Population -- Benefits of Exercise in the Elderly -- The RAAS in Heart Failure: An Update on Clinical Trials and Opportunities for Therapy -- Aging and Diastolic Dysfunction: The Interplay of Inflammation and Extracellular Matrix Regulation -- Reperfusion and Vasodilator Therapy in Elderly Patients with STEMI and Heart Failure: Improving Outcomes -- Erythropoietin Therapy for Heart Failure -- Role of Resistin in Heart Failure in the Elderly -- Role of Coronary Artery Calcium in Cardiovascular Risk Stratification and Management in the Aging Population -- Aging and Remodeling of the RAS and RAAS and Related Pathways: Implications for Heart Failure Therapy -- Aging and Right Ventricular Failure from Pulmonary Hypertension: Effect of Right Ventricular and Pulmonary Artery Remodeling -- Aging and Right Ventricular Failure from Pulmonary Hypertension: Effect of Right Ventricular and Pulmonary Artery Remodeling -- Biomarkers of Cardiovascular Aging -- Changes in the Heart That Accompany Advancing Age: Humans to Molecules -- Aging-Related Changes in Cell Death and Cell Survival Pathways and Implications for Heart Failure Therapy -- Aging-Related Changes in Telomeres and Telomerases and Implications for Heart Failure Therapy -- Aging-Associated Alterations in Myocardial Inflammation and Fibrosis: Pathophysiological Perspectives and Clinical Implications -- Aging-Related Changes in Extracellular Matrix: Implications for Ventricular Remodeling Following Myocardial Infarction -- Calcium-Handling Defects and Changes in Cardiac Function in the Aging Heart -- Integrins: Implications for Aging in Heart Failure Therapy -- Adipokines as Novel Biomarkers in Aging and Heart Failure -- Aging-Related Changes in Cellular and Molecular Mechanisms of Postinfarction Remodeling: Implications for Heart Failure Therapy -- Aging-Related Changes in Mitochondrial Function and Implication for Heart Failure Therapy -- Regulation of SERCA Via Oxidative Modifications: Implications for the Pathophysiology of Diastolic Dysfunction in the Aging Heart -- SMP30 and Aging-Related Cardiac Remodeling and Heart Failure.
Format
e-Book
Location
Online
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Chronic Kidney Disease and Hypertension

https://libcat.nshealth.ca/en/permalink/provcat38992
Matthew R. Weir, Edgar V. Lerma, editors. --New York, NY: Springer New York : Imprint: Humana Press , c2015.
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The treatment of hypertension has become the most important intervention in the management of all forms of chronic kidney disease. Chronic Kidney Disease and Hypertension is a current, concise, and practical guide to the identification, treatment and management of hypertension in patients with chronic kidney disease. In depth chapters discuss many relevant clinical questions and the future of treatment through medications and or novel new devices. Written by expert authors, Chronic Kidney Disea…
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Other Authors
Weir, Matthew R
Lerma, Edgar V
Responsibility
Matthew R. Weir, Edgar V. Lerma, editors
Place of Publication
New York, NY
Publisher
Springer New York : Imprint: Humana Press
Date of Publication
c2015
Physical Description
1 online resource (xiii, 257 p. : 40 illus., 19 illus. in color)
Series Title
Clinical hypertension and vascular diseases
ISBN
9781493919826
9781493919819 (print ed.)
Subjects (MeSH)
Hypertension, Renal - complications
Renal Insufficiency, Chronic - etiology
Abstract
The treatment of hypertension has become the most important intervention in the management of all forms of chronic kidney disease. Chronic Kidney Disease and Hypertension is a current, concise, and practical guide to the identification, treatment and management of hypertension in patients with chronic kidney disease. In depth chapters discuss many relevant clinical questions and the future of treatment through medications and or novel new devices. Written by expert authors, Chronic Kidney Disease and Hypertension provides an up-to-date perspective on management and treatment and how it may re-shape practice approaches tomorrow.
Contents
Changes in Guideline Trends and Applications in Practice: JNC 2013 and the future -- Central BP monitoring, Home BP Monitoring, Ambulatory BP Monitoring in CKD -- Resistant hypertension in patients with chronic kidney disease -- Neurogenic Factors In Hypertension Associated With Chronic Kidney Disease -- Novel Molecules -- Dual Inhibitors: RAAS Blockers/Combination Therapies: What Do All These Trials Mean? -- Renal Sympathetic Denervation -- Novel baroreceptor activation therapy -- Blood Pressure Vaccines -- Masked Hypertension: Does it Lead to CVD or CKD? -- White Coat Hypertension: Do We Really Understand It Now? -- Uric Acid And Hypertension: Is There Really A Link? -- Preeclampsia: Angiogenic factors, blood pressure, and the kidney -- Inflammation and Hypertension -- Genome-Wide Association Studies (Gwas) Of Blood Pressure In Different Populations -- Endocrine Hypertension and Chronic Kidney Disease -- Hypertension in Children with Chronic Kidney Disease -- Obesity/OSA/Metabolic syndrome in pts with CKD and hypertension: the missing link.
Format
e-Book
Location
Online
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Hypertension and Renal Organ Damage

https://libcat.nshealth.ca/en/permalink/provcat42762
Roberto Pontremoli. --Cham: Springer , c2018.
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This book guides readers through a wide spectrum of clinical presentations in patients with arterial hypertension and different degrees of renal impairment, ranging from asymptomatic urine abnormalities to end stage renal disease. On the basis of six case studies, the author reviews and discusses current guidelines and recommendations aimed at optimizing the diagnostic and therapeutic approach both to renal and cardiovascular risk in commonly encountered real-world clinical scenarios including …
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Author
Pontremoli, Roberto
Responsibility
Roberto Pontremoli
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2018
Physical Description
1 online resource (xiii, 75 p.) : 25 illus., 23 illus. in color
Series Title
Practical case studies in hypertension management
ISBN
9783319564081
9783319564074 (print ed.)
9783319564098 (print ed.)
ISSN
2364-6632
Subjects (MeSH)
Hypertension - complications
Kidney Diseases
Urination Disorders
Specialty
Cardiology
Nephrology
Abstract
This book guides readers through a wide spectrum of clinical presentations in patients with arterial hypertension and different degrees of renal impairment, ranging from asymptomatic urine abnormalities to end stage renal disease. On the basis of six case studies, the author reviews and discusses current guidelines and recommendations aimed at optimizing the diagnostic and therapeutic approach both to renal and cardiovascular risk in commonly encountered real-world clinical scenarios including challenging cases of diabetic kidney disease, ischemic nephropathy and resistant hypertension. It also explores anti-hypertensive drug combinations, including single or multiple RAAS-I, lipid lowering and antiplatelet drugs, as well as the appropriate use of glucose lowering drugs in the context of chronic kidney disease. This handy and practical book provides physicians in the area of general and internal medicine, as well as specialists in the cardiovascular, metabolic and renal fields valuable insights into optimal therapeutic targets for blood pressure and glucose control in renal patients.
Contents
Clinical Case 1. Patient with Hypertension and Reduced Glomerular Filtration Rate -- Clinical Case 2. Patient with Hypertension and Microalbuminuria -- Clinical Case 3. Patient with Hypertension and Mild Proteinuria -- Clinical Case 4. Patient with Hypertension and Overt Proteinuria -- Clinical Case 5. Patient with Hypertension and End-Stage Renal Disease -- Clinical Case 6. Patient with Hypertension on Dialysis.
Format
e-Book
Location
Online
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The Local Cardiac Renin-Angiotensin Aldosterone System

https://libcat.nshealth.ca/en/permalink/provcat29683
Edward D. Frohlich, Richard N. Re, editors. (2nd ed.) --Boston, MA: Springer-Verlag US , c2009.
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How exciting it is to see a field so well established as the ren- angiotensin system continue to grow and mature. Originally, following the original identification of renin by Tigerstedt and Bergman over 100 years ago, workers in this area spent years attempting to establish its role in experimental and renal hypertension. The early work by Goldblatt, in 1934, demonstrated that the placement of a clip around a renal artery was clearly related to the subsequent development of hypertension. Howev…
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Author
Frohlich, Edward D
Other Authors
International Workshop on the Local Cardiac Renin Angiotensin Aldosterone System (3rd : 2008 : New Orleans, La.)
Other Authors
Re, Richard N
Responsibility
Edward D. Frohlich, Richard N. Re, editors
Edition
2nd ed.
Place of Publication
Boston, MA
Publisher
Springer-Verlag US
Date of Publication
c2009
ISBN
9781441905284
Subjects (MeSH)
Cardiology - Congresses
Hypertension - metabolism
Receptors, Cell Surface - physiology
Renin-Angiotensin System - physiology
Vacuolar Proton-Translocating ATPases - metabolism
Subjects (LCSH)
Cardiology
Physiology
Abstract
How exciting it is to see a field so well established as the ren- angiotensin system continue to grow and mature. Originally, following the original identification of renin by Tigerstedt and Bergman over 100 years ago, workers in this area spent years attempting to establish its role in experimental and renal hypertension. The early work by Goldblatt, in 1934, demonstrated that the placement of a clip around a renal artery was clearly related to the subsequent development of hypertension. However, it wasn't until the simultaneous finding by two different geographically separated teams, Page, et al, in the United States and Braun-Menendez, et al, in Argentina that the peptide angiotensin was identified. Thus, the rate-limiting enzyme renin was released from the kidney and catalyzed a biochemical cascade which was eventually shown to produce the elevated arterial pressure. Subsequently, many workers contributed to the elucidation of the concept and sequence of angiotensin I1 generation. Thus, the enzyme renin acted upon its protein substrate, produced in the liver, to liberate the decapeptide angiotensin I which, upon circulating through the pulmonary circulation, finally produced the potent octapeptide angiotensin. Several important subsequent findings demonstrated that angiotensin I1 promoted the release of the adrenal corticosteroid from that gland, thereby resulting in a larger system, the renin-angiotensin-aldosterone system. Further, this system demonstrated a classical biofeedback and the circulating octapeptide was shown to have additional biological activities in organs other than heart, vessels, kidney, adrenals, and even brain.
Contents
1. Are Local Renin–Angiotensin Systems the Focal Points for Understanding Salt Sensitivity in Hypertension? -- 2. Newer Insights into the Biochemical Physiology of the Renin–Angiotensin System: Role of Angiotensin-(1-7), Angiotensin Converting Enzyme 2, and Angiotensin-(1-12) -- 3. Renin, Prorenin, and the (Pro)renin Receptor -- 4. Intracellular Accumulation and Nuclear Trafficking of Angiotensin II and the Angiotensin II Type 1 Receptor -- 5. Pathophysiologic Implications of Cell Swelling in the Failing Heart: Influence of Intracrine and Extracellular Renin–Angiotensin Systems -- 6. Exploiting Rat Genetics to Investigate Hypertensive End-Organ Damage -- 7. Alternative Renin Transcripts and Functions of Cytoplasmatic Renin -- 8. Novel Aspects of the Cardiac Renin–Angiotensin System -- 9. Intracrine Function from Angiotensin to Stem Cells -- 10. Renin Cell Identity and Homeostasis -- 11. Role of Renal Aminopeptidases and Angiotensin Type-2 (AT2) Receptors in Sodium Excretion and Hypertension -- 12. Intrarenal Angiotensin II Augmentation in Hypertension -- 13. Collecting Duct Renin: A Critical Link in Angiotensin II-Dependent Hypertension -- 14. Renin–Angiotensin–Aldosterone System and Cardiomyocyte Apoptosis in Hypertensive Heart Disease -- 15. Upregulation of Angiotensin II Type 2 Receptor (agtr2) Attenuates Atherosclerotic Lesion Formation and Enhances Apoptosis in the LDL Receptor Knockout Mice Fed High Cholesterol Diet -- 16. Salt and Heart: RAAS Involvement -- 17. Cardiac Effects of Aldosterone, the Bad, but Is There Also a Good?
Format
e-Book
Location
Online
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Special issues in hypertension

https://libcat.nshealth.ca/en/permalink/provcat31256
Adel E. Berbari, Giuseppe Mancia, editors. --Milan: Springer , c2012.
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This volume is a cutting-edge review of the latest findings on key scientific and clinical issues in hypertension, with an integration of different new specific topics into the general knowledge of how to understand the pathophysiology and correctly diagnose and treat this chronic condition, which still represents the first cause of death in the world. Among the topics included in the book the reader will find some forms of hypertension which are frequently encountered in clinical practice and …
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Other Authors
Berbari, Adel E
Mancia, Giuseppe
Responsibility
Adel E. Berbari, Giuseppe Mancia, editors
Place of Publication
Milan
Publisher
Springer
Date of Publication
c2012
Physical Description
1 online resource (x, 483 p. : 69 ill.)
ISBN
9788847026018
Subjects (MeSH)
Hypertension
Subjects (LCSH)
Angiography
Cardiology
Abstract
This volume is a cutting-edge review of the latest findings on key scientific and clinical issues in hypertension, with an integration of different new specific topics into the general knowledge of how to understand the pathophysiology and correctly diagnose and treat this chronic condition, which still represents the first cause of death in the world. Among the topics included in the book the reader will find some forms of hypertension which are frequently encountered in clinical practice and on which new important evidence is available, such as high-normal blood pressure (also termed pre-hypertension), white-coat and masked hypertension, and high blood pressure in the elderly and the very elderly. These emerging aspects are discussed in detail, along with chapters on issues of great current interest, such as the way to assess and how to treat asymptomatic organ damage, emerging cardiovascular risk factors such as short and long-term blood pressure variability, cognitive impairment and dementia. The book also deals with the changing concepts in the management of hypertension and antihypertensive pharmacotherapy, and addresses specific topics which are rarely discussed in clinical medicine volumes, including hypertension in post-menopausal women, hormonal replacement therapy, inflammatory disorders, sexual dysfunction with treatment, and the effect of Ramadan fasting on blood pressure. This ready to hand but encompassing volume proves to be a comprehensive updating tool to professionals and clinical practitioners managing patients with hypertension.
Contents
1. Prehypertension: Definition, clinical significance and therapeutic approaches: to treat or not to treat -- 2. Clinical significance and treatment requirement in white coat and masked hypertension -- 3. Resistant hypertension: epidemiologic and evolving therapeutic aspects -- 4. Primary aldosteronism: rare or common condition -- 5. Hypertension in the very elderly: special features, therapeutic approaches and problems -- 6. Clinical relevance of circadian rhythm and nocturnal dip -- 7. Morning BP surge in treated and untreated hypertensive patients: clinical relevance, prognostic significance and therapeutic approaches -- 8. Short-term and long-term BP variability -- 9. Home BP in hypertension -- 10. Obstructive sleep apnea -- 11. Hypertension, obesity and the metabolic syndrome -- 12.Salt, hypertension and cardiovascular disease -- 13. Optic fundus and retinal circulation: new technology for an old examination -- 14. Arterial stiffness as an early marker of organ damage -- 15. Central blood pressure: definition, clinical significance and therapeutic approaches -- 16. Assessment of total cardiovascular risk in Hypertension: the role of subclinical organ damage -- 17. Microcirculation in hypertension -- 18. Smoking, nicotine and BP -- 19. Inflammatory markers and other risk factors in Hypertension -- 20. Benefits: pleiotropic versus BP dependent mechanisms -- 21. Threshold and target BP values for treatment: an evolving concept -- 22. Polypill concept -- 23. J-curve phenomenon: Does it exist? -- 24. Residual risk in treated hypertension -- 25. Poor BP control in the hypertensive population: which factors are involved -- 26. Ramadan fasting and BP control -- 27. Hormone replacement therapy in postmenopausal hypertensive women -- 28. Treating pain and inflammation in hypertension -- 29. Sexual function in untreated and treated hypertension -- 30. Cognitive function and dementia in hypertension. Epidemiologic and therapeutic aspects -- 31 Is hypertension preventable? -- 32. Atrial fibrillation. Modern epidemiologic and therapeutic aspects -- 33. Genetics and hypertension. Which information for clinical practice -- 34. Dual blockade of RAAS: benefits versus adverse Outcome -- 35. Long-term effects of RAAS blockade on renal function.
Format
e-Book
Location
Online
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6 records – page 1 of 1.