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The CAPRISA Clinical Trials : HIV Treatment and Prevention

https://libcat.nshealth.ca/en/permalink/provcat41582

Quarraisha Abdool Karim, Salim S. Abdool Karim, Cheryl Baxter, editors. --Cham: Springer , 2017.

Available Online: View e-Book

Location: Online

Since its inception 14 years ago, CAPRISA has conducted numerous clinical studies that have influenced international TB-HIV treatment guidelines as well as HIV prevention through innovations in the microbicide and vaccine fields. This book provides a historical account of how each of CAPRISA's high impact studies was created, developed, implemented, analysed and communicated. In doing so, the reader is taken on a journey that provides glimpses into the genesis of research ideas and how this ult…

Available Online: View e-Book

Other Authors: Abdool Karim, Quarraisha; Abdool Karim, Salim S.; Baxter, Cheryl

Responsibility: Quarraisha Abdool Karim, Salim S. Abdool Karim, Cheryl Baxter, editors

Place of Publication: Cham

Publisher: Springer

Date of Publication: 2017

Physical Description: 1 online resource (vi, 243 pages) : 24 illus., 23 illus. in color

ISBN: 9783319475189; 9783319475172 (print ed.)

Subjects (MeSH): Anti-HIV Agents - therapeutic use; Clinical Trials as Topic; HIV Infections - drug therapy; HIV Infections - prevention & control

Other Subjects: South Africa

Abstract: Since its inception 14 years ago, CAPRISA has conducted numerous clinical studies that have influenced international TB-HIV treatment guidelines as well as HIV prevention through innovations in the microbicide and vaccine fields. This book provides a historical account of how each of CAPRISA's high impact studies was created, developed, implemented, analysed and communicated. In doing so, the reader is taken on a journey that provides glimpses into the genesis of research ideas and how this ultimately leads to a range of HIV prevention and treatment studies that have impacted the global response to the HIV and TB epidemics. Comprised of 5 sections, the book details the following: HIV epidemic in South Africa and the establishment of a research centre to undertake clinical, epidemiological and laboratory research on HIV. CAPRISA's clinical trials on HIV and HSV-2 prevention. These studies investigated the impact of tenofovir gel as topical antiretroviral pre-exposure prophylaxis (PrEP), implementation of topical PrEP through family planning clinics, conditional cash incentives for HIV prevention, HIV vaccines, and passive immunisation with broadly neutralising antibodies. CAPRISA's research on the treatment of HIV and TB co-infection. A review of the major scientific findings from the CAPRISA studies on acute infection and genital mucosal immunology. Essential support activities for the conduct of clinical trials, including research laboratories and pharmacies, as well as establishing effective communication and sustainable structures for community engagement to maintain effective and respectful partnerships with participating communities. The book concludes with a chapter about the challenges facing future HIV prevention and treatment trials. The CAPRISA Clinical Trials: HIV Treatment and Prevention is a resource for undergraduate and postgraduate students, health care providers, doctors, decision-makers and researchers who are seeking guidance and insights on clinical trials--their creation, conduct and impact.

Contents: Part I: Introduction/Background -- 1. Studies Linked to the Evolving HIV Epidemic in South Africa: Informing the CAPRISA Scientific Agenda -- 2. CAPRISA: Establishing a Research Centre to Undertake HIV Clinical Trials -- 3. Overview of Clinical Trials -- Part II: CAPRISA Clinical Trials for HIV and HSV-2 Prevention -- 4. Antiretrovirals for HIV Prevention: The CAPRISA 004 Tenofovir Gel Trial -- 5. Rolling Out of Tenofovir Gel in Family Planning Clinics: The CAPRISA 008 Implementation Trial -- 6. The Impact of Conditional Cash Transfers in Reducing HIV in Adolescent Girls and Boys (RHIVA): The CAPRISA 007 Matched Pair, Cluster Randomised Controlled Trial -- 7. HIV Vaccine and Passive Immunity Trials -- Part III: CAPRISA Clinical Trials for HIV–TB Treatment -- 8. CAPRISA 003: Timing of Antiretroviral Initiation in HIV-TB Co-infected Patients—The SAPiT Trial -- 9. Scaling up TB-HIV Integration in Public Health Clinics: Translating Research Findings into Practice -- Part IV: Experiences and Lessons Learnt from Clinical Trials in CAPRISA -- 10. From Bench to Bedside: Lessons from HIV Natural History Cohort Studies -- 11. Advancing Understanding of HIV Infection in Women Through Mucosal Immunology Studies -- Part V: Essential Support Activities for the Conduct of Clinical Trials -- 12. Good Practices in the Conduct of Clinical Trials: Good Community, Pharmacy and Laboratory Practices -- 13. Ethical and Legal Considerations for Realising Post-trial Access of Novel Experimental Interventions: Lessons from the CAPRISA 004 Trial -- 14. Grants Management -- 15. Taking Science to the People: CAPRISA Communication and Media Strategies for Announcing Outcomes of Pivotal Study Findings -- 16. What Does the Future Hold for CAPRISA?

Format: e-Book

Location: Online

Pathology of the Gastrointestinal Tract

https://libcat.nshealth.ca/en/permalink/provcat41370

Fátima Carneiro, Paula Chaves, Arzu Ensari, editors. --Cham: Springer , c2017.

Available Online: View e-Book

Location: Online

This book covers the complete field of the pathology of the Gastrointestinal tract - from Abetalipoproteinemia to Zollinger-Ellison Syndrome. The alphabetically arranged entries, each of which provides a detailed description of a specific pathological disease pattern, allow readers to quickly and easily find the information they need.

Available Online: View e-Book

Other Authors: Carneiro, Fátima; Chaves, Paula; Ensari, Arzu

Responsibility: Fátima Carneiro, Paula Chaves, Arzu Ensari, editors

Place of Publication: Cham

Publisher: Springer

Date of Publication: c2017

Physical Description: 1 online resource (xxiv, 701 pages) : 480 illus., 473 illus. in color

Series Title: Springer reference; Encyclopedia of pathology

ISBN: 9783319405605; 9783319405599 (print ed.)

ISSN: 2366-6269

Subjects (MeSH): Digestive System Diseases - pathology; Gastrointestinal Tract - pathology

Notes: "eReference"--Publisher.

Abstract: This book covers the complete field of the pathology of the Gastrointestinal tract - from Abetalipoproteinemia to Zollinger-Ellison Syndrome. The alphabetically arranged entries, each of which provides a detailed description of a specific pathological disease pattern, allow readers to quickly and easily find the information they need.

Contents: Abetalipoproteinemia -- Achalasia, esophagus -- Acute Gastritis -- Adenoacanthoma -- Adenocarcinoma, Upper Gastro-Intestinal Tract -- Adenoid Cystic Carcinoma, Esophageal -- Adenoma, Colorectal -- Adenoma, Upper Gastro-Intestinal Tract -- Adenosquamous carcinoma, Upper GI tract -- Adhesions -- Adipose Tissue Tumors, Stomach -- Amyloidosis, Gastro-Intestinal -- Anal adenocarcinoma -- Angiodysplasia -- Antibiotic Associated Colitis -- Antrum -- Anus -- Appendiceal Tumors -- Appendicitis -- Appendix -- Autoimmune Gastritis -- Bacterial Enterocolitis -- Bacterial Overgrowth Syndrome -- Barium Sulphate, Oesophageal Inclusions -- Barrett's Esophagus -- Basal cell carcinoma of the anal margin -- Basaloid-Squamous Carcinoma, Upper GI Tract -- Cameron`s Ulcer -- Campylobacter Enterocolitis -- Carcinoma, Colorectal -- Carcinoma, Periampullary -- Carcinoma, Small Intestine -- Cardia -- Chagas Disease, Gastro-Intestinal Aspects -- CHARGE syndrome, Esophagus -- Cholera -- Choriocarcinoma, Gastro-Intestinal -- Chronic Gastritis -- C-Kit (CD117), Gastrointestinal Stromal Tumors (GISTs) -- Coeliac Disease -- Collagen Vascular Disorders, Esophagus -- Collagenous Colitis -- Collagenous Gastritis -- Colon -- Condyloma, Anal -- Cowden`s Syndrome -- Crohn`s Disease -- Cronkhite-Canada Syndrome -- Cushings and Curlings Ulcer -- Diaphramatic Hernia -- Dieulafoy's Lesion -- Disaccharidase Deficiency -- Diversion Colitis -- Diverticular Colitis -- Diverticular Disease, Colon -- Diverticulum Epiphrenic -- Drug Induced Esophagitis -- Drug Induced Gastritis -- Drug-Induced Intestinal Injury -- Duplication, Esophagus -- Duplication, Intestinal -- Dysentery, Bacillary -- E-cadherin, Gastric Carcinoma -- Enteropathy, AIDS -- Enteropathy, Neonatal (congenital) -- Eosinophilic Colitis -- Eosinophilic Esophagitis -- Eosinophilic Gastritis -- Epstein-Barr Virus (EBV), Esophagitis -- Esophageal Atresia -- Esophagitis, Chemotherapy Induced -- Esophagitis, In Crohn`s Disease -- Fundic Gland Polyp -- Gangliocytic Paraganglioma, Duodenal -- Ganglioneuroma, Gastrointestinal -- Gastric epithelial dysplasia -- Gastric Heterotopia -- Gastric Stump -- Gastritis Cystica Polyposa/Profunda -- Gastroesophageal Junction -- Gastroesophageal Reflux Disease (GERD) -- Gastrointestinal Autonomic Nerve Tumor -- Gastrointestinal Stromal Tumor -- Gastroparesis -- Gastropathy, Portal Hypertension -- GAVE (Gastric Antral Vascular Ectasia) -- Giardiasis -- Glomus Tumor, Gastro-Intestinal -- Glycogenic Ancanthosis -- Goblet cells -- Graft-Versus-Host Disease -- Granular Cell Tumor, Gastro-Intestinal -- Granulomatous Gastritis -- Hamartomatous Polyps -- Helicobacter Heilmannii Infection -- Helicobacter Pylori Infection -- Hemorrhoid Hernias -- Hiatus Hernia, Acquired, Para-Esophageal (Rolling) -- Hirschsprung`s Disease -- Hyperplastic Polyps -- Immunoproliferative Small Intestinal Disease -- Infarction,Intestinal -- Infectious Colitis -- Infectious Esophagitis -- Inflammatory Bowel Disease -- Inflammatory Cloacogenic Polyp -- Inflammatory Fibroid Polyp, Lower Gastro-Intestinal Tract -- Inflammatory Fibroid Polyp, Upper Gastro-Intestinal Tract -- Inflammatory Myofibroblastic Tumor, Upper Gastro-Intestinal Tract -- Inperforate Anus -- Intestinal Atresia -- Intestinal Immune System -- Intestinal Lymphangiectasia -- Intestinal Malrotation -- Intestinal metaplasia -- Intestinal Obstruction -- Intestinal Pseudoobstruction -- Intestinal Tuberculosis -- Intusseption -- Ischaemic Bowel Disease -- Ischaemic Colitis -- Ischaemic Gastritis -- Juvenile Polyp, Upper Gastro-Intestinal Tract -- Juvenile Polyposis Syndrome, Lower Gastro-Intestinal Tract -- Lewy Bodies, Achalasia -- Lymphocytic Colitis -- Lymphocytic Esophagitis -- Lymphocytic Gastritis -- Lymphoepithelial-Like Carcinoma -- Lymphoma, Gastrointestinal -- Lynch Syndrome -- Malabsorption -- Malignant Atrophic Papulosis (Degos`Disease) -- Malignant -- Melanoma, Anus -- Mallory Weiss Lacerations, Esophageal -- Meckel`s Diverticulum -- Menetrier`s Disease (Hypertrophic Gastropathy) -- Microscopic Colitis -- Microvillus Inclusion Disease -- Mucinous Carcinoma, Upper Gastro-Intestinal Tract -- Mucinous Cystadenocarcinoma, Appendix -- Mucinous Cystadenoma, Appendix -- Mucins -- Mucocele, Appendix -- Mucoepidermoid Carcinoma, esophageal -- Mucosal Prolapsus Syndrome -- Necrotizing Enterocolitis -- Neuroendocrine neoplasms of the anus -- Neuroendocrine Tumor, Colon and Rectum -- Neuroendocrine Tumor, Esophagus -- Neuroendocrine Tumor, Gastric -- Neuroendocrine Tumor, Small Intestine -- Neuropenic Colitis -- Nonsteroidal Antiinflammatory Drug Injury -- Nonsteroidal anti-inflammatory drug (NSAIDs) -- Pagetas disease of the anus -- Pancreatic Heterotopia -- Parasitic Colitis -- Pemphigoid, Bullous, Esophageal -- Pemphigus Vulgaris, Esophageal -- Peptic Duodenal Disease -- Peptic Ulcer -- Peutz-Jeghers Syndrome -- Plummer-Vinson Syndrome -- Polyp, Gastrointestinal -- Polyposis Syndromes -- Pseudodiverticulum (Pseudodiverticula), Esophageal -- Pseudoepitheliomatous Hyperplasia, Esophageal -- Pseudogoblet Cells -- Pyloric Gland Adenoma -- Pyloric Stenosis -- Radiation Colitis -- Radiation induced Esophagitis -- Radiation Therapy Injury -- Rectum -- Salmonellosis -- Sarcoidosis, Gastro-Intestinal -- Scleroderma, Esophageal -- Serrated Polyposis Syndrome -- Shigellosis -- Short gut syndrome -- Signet Ring Cell Carcinoma -- Small Intestine -- Solitary Rectal Ulcer Syndrome -- Squamous Cell Carcinoma, Anus -- Squamous Cell Carcinoma, Upper Gastro-Intestinal Tract -- Squamous Papilloma, Upper Gastro-Intestinal Tract -- Tropical Sprue -- Tubular Adenocarcinoma -- Tufting Enteropathy -- Typhoid Fever -- Ulcerative Colitis -- Uremic Gastropathy -- Varices -- Vasculitis, Upper Gastro-Intestinal Tract -- Verrucous carcinoma/Giant condyloma of Buschke and Lowenstein -- Viral Colitis -- Viral Gastroenteritis -- Volvulus -- Xanthoma, Upper Gastro-Intestinal Tract -- Zenker`s Diverticulum -- Z-Line -- Zollinger-Ellison-Syndrome.