IL-17, IL-22 and their producing cells : role in inflammation and autoimmunity
https://libcat.nshealth.ca/en/permalink/provcat32482
Valérie Quesniaux, Bernhard Ryffel, Franco Padova, editors.
(2nd ed.)
--Basel:
Springer
, c2013.
- Available Online
- View e-Book
- Location
- Online
The knowledge of Th17 cells and other cell populations which secrete IL-17A, and/or IL-22 has expanded tremendously since the publication of the first edition "Th17 Cells: Role in Inflammation and Autoimmune Disease" in 2008. The present volume has been completely revised with the addition of new chapters on the IL-17 receptor family and signaling, and an in-depth review of IL-22 and innate lymphoid cells. The differentiation of naive T cells into regulatory T cells and Th17 cells as well as th…
- Available Online
- View e-Book
- Other Authors
- Quesniaux, Valérie
- Ryffel, Bernhard
- Padova, Franco
- Responsibility
- Valérie Quesniaux, Bernhard Ryffel, Franco Padova, editors
- Edition
- 2nd ed.
- Place of Publication
- Basel
- Publisher
- Springer
- Date of Publication
- c2013
- Physical Description
- 1 online resource (ix, 354 p. : 25 ill., 14 ill. in color)
- Series Title
- Progress in inflammation research
- ISBN
- 9783034805223
- Subjects (MeSH)
- Immunity, Cellular - physiology
- Inflammation - physiopathology
- Interleukin-17 - immunology
- Interleukins - immunology
- Subjects (LCSH)
- Oncology
- Immunology
- Infectious diseases
- Cell receptors
- Cytokines
- Cytology
- Abstract
- The knowledge of Th17 cells and other cell populations which secrete IL-17A, and/or IL-22 has expanded tremendously since the publication of the first edition "Th17 Cells: Role in Inflammation and Autoimmune Disease" in 2008. The present volume has been completely revised with the addition of new chapters on the IL-17 receptor family and signaling, and an in-depth review of IL-22 and innate lymphoid cells. The differentiation of naive T cells into regulatory T cells and Th17 cells as well as the plasticity of Th17 cells is discussed. The role of IL-22 in cutaneous inflammation including psoriasis has been reviewed. In addition, the volume contains critical updates on autoimmunity, organ transplantation, tumor immunology and genetic mouse models for mechanistic studies. Lastly, the latest clinical progress in neutralizing antibodies to IL-17A, IL-17RA not only confirms the therapeutic promise foreseen in 2008, but also improves our knowledge of the pathogenesis of autoimmune diseases. In summary, this is a timely update and important review of the clinical and experimental aspects of IL-17, IL-22 and their producing cells.
- Contents
- IL-17A family, receptors, proinflammatory effects and production -- IL-22 and IL-17 overview -- IL-17R family: Structure, signal transduction and function -- Contribution of IL-22 to Th17 responses: repairing and protecting peripheral tissues -- Central role of Th-17 cells in adaptive immune responses -- Regulatory T cells vs Th17: Differentiation of Th17 versus Treg are they mutually exclusiveáOther sources of IL-17: iNKT cells -- Retinoic acid in mucosal immune regulation -- Critical role of IL-17 in experimental arthritis -- Dual role IL-17A, F and IL-22 in allergic asthma -- Inflammasome - IL-1 - IL-17 response in lung inflammation -- The role of Il-17 in exp autoimmune mycocarditis -- Th17 cells in transplantation: actors or innocent bystanders -- Is IL-17 required to control of tuberculosisáIL-17 and mucosal host defense. Role of IL-17 and IL-17 family cytokines on tumor development -- IL-17 and TH17 cells in rheumatoid arthritis and other inflammatory conditions -- Targeting Th17 Cells for therapy of multiple sclerosis -- Involvement of interleukin-17 cytokines in human asthma -- IL-17 and/or IL-22 as potential target(s) for Crohn's disease -- Role of IL-23, IL-17 and IL-22 in psoriasis -- Contribution of IL-22 to experimental skin inflammation -- Genetic mouse models to investigate IL-17 responses -- IL-17A as a therapeutic target for autoimmune diseases -- Index.
- Format
- e-Book
- Location
- Online
Th 17 Cells : Role in Inflammation and Autoimmune Disease
https://libcat.nshealth.ca/en/permalink/provcat40954
Valérie Quesniaux, Bernhard Ryffel, Franco Di Padova, editors.
--Basel:
Birkhäuser Verlag
, c2009.
- Available Online
- View e-Book
- Location
- Online
With the recent definition of the Th17 cell subset, a new paradigm in innate and adaptive immunity has been established. This book describes the function of the Th17 cell subset and its prevalent role in many inflammatory and autoimmune diseases. The mechanism by which this T cell subset is generated and maintained shows specific differences between mice and man which are reviewed. One characteristic of Th17 cells is to secrete specific and unique cytokines such as IL-17A, IL-17F and IL-22; the…
- Available Online
- View e-Book
- Other Authors
- Quesniaux, Valérie
- Ryffel, Bernhard
- Padova, Franco Di
- Responsibility
- Valérie Quesniaux, Bernhard Ryffel, Franco Di Padova, editors
- Place of Publication
- Basel
- Publisher
- Birkhäuser Verlag
- Date of Publication
- c2009
- Physical Description
- 1 online resource (xii, 244 p. : 20 illus.)
- Series Title
- Progress in inflammation research
- ISBN
- 9783764386818
- 9783764386801 (print ed.)
- Subjects (MeSH)
- Antibodies, Neutralizing
- Autoimmune Diseases - etiology
- Inflammation - etiology
- Th17 Cells - immunology
- Abstract
- With the recent definition of the Th17 cell subset, a new paradigm in innate and adaptive immunity has been established. This book describes the function of the Th17 cell subset and its prevalent role in many inflammatory and autoimmune diseases. The mechanism by which this T cell subset is generated and maintained shows specific differences between mice and man which are reviewed. One characteristic of Th17 cells is to secrete specific and unique cytokines such as IL-17A, IL-17F and IL-22; their functions are described in detail. These cytokines have acquired a prevalent role in many pathological conditions in animal models and in humans. Targeting these cytokines as well as the generation of Th17 cells may open new ways to treat many autoimmune diseases. The role of Th17 in infectious conditions is also addressed.
- Contents
- Discovery and IL-17 family -- IL-22 and IL-17: Common and different properties -- Other sources of IL-17: Invariant natural killer T cells -- Contributions of IL-22 to Th17 responses: Repairing and protecting peripheral tissues -- Retinoic acid in mucosal immune-regulation -- IL-25, another promoter of allergy -- Experimental models of disease -- Critical role of IL-17 in experimental arthritis -- Dual role of IL-17 in allergic asthma -- Contribution of IL-17 to the pulmonary inflammatory response -- The role of IL-17 in experimental autoimmune myocarditis -- Th17 cells in organ transplantation -- Role of IL-23/IL-17 in infection and tumor control -- Is IL-17 required to control tuberculosis? -- IL-17 and mucosal host defense -- IL-23 orchestrates the switch from tumor immune surveillance to tumor-promoting inflammation -- IL-17 in clinical autoimmune disease -- IL-17 and Th17 cells in rheumatoid arthritis -- Targeting Th17 cells in CNS immune pathology -- IL-17 cytokines in asthma -- IL-17/23, potential targets for Crohn's disease -- Novel tools and therapeutic avenues -- IL-17A and Th17 cells as therapeutic targets for autoimmune diseases.
- Format
- e-Book
- Location
- Online
