Biology and Pathology of Perineuronal Satellite Cells in Sensory Ganglia
https://libcat.nshealth.ca/en/permalink/provcat42949
Ennio Pannese.
--Cham:
Springer
, c2018.
- Available Online
- View e-Book
- Location
- Online
This volume provides a comprehensive and updated review of perineuronal satellite cells in sensory ganglia. For a long time since their discovery by Valentin in the first half of the 19th century these cells received only modest attention. However, some years ago research findings suggested that satellite cells play a role in the development and maintenance of neuropathic pain. As a result, satellite cells are now considered as possible targets for neuropathic pain treatment. Thus, interest in …
- Available Online
- View e-Book
- Author
- Pannese, Ennio
- Responsibility
- Ennio Pannese
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2018
- Physical Description
- 1 online resource (xi, 83 p.) : 36 illus., 33 illus. in color
- Series Vol.
- 226
- Series Title
- Advances in anatomy, embryology and cell biology
- ISBN
- 9783319601403
- 9783319601397 (print ed.)
- 9783319601410 (print ed.)
- ISSN
- 0301-5556
- Specialty
- Neurology
- Abstract
- This volume provides a comprehensive and updated review of perineuronal satellite cells in sensory ganglia. For a long time since their discovery by Valentin in the first half of the 19th century these cells received only modest attention. However, some years ago research findings suggested that satellite cells play a role in the development and maintenance of neuropathic pain. As a result, satellite cells are now considered as possible targets for neuropathic pain treatment. Thus, interest in satellite cells has burgeoned. The review is based on the author's own work as well as on his critical evaluation and systematic arrangement of data scattered through a large number of research papers. The following aspects of perineuronal satellite cells are covered: Shape and structure; molecular characteristics; origin and development; biological and functional properties; relationships with the ganglion sensory neuron; age-related changes; roles under physiological conditions; reactions to experimental and pathological conditions; role in neuropathic pain.
- Contents
- 1. Historical Note -- 2. Organization of the Perineuronal Sheath in Adult Vertebrates -- 3. Shape of Satellite Cells -- 4. Structure of Satellite Cells -- 5. Molecular Characteristics of Satellite Cells -- 6. Relationships Between Satellite Cells -- 7. Perikaryal Myelin Sheaths -- 8. Neuron-Satellite Cell Boundary -- 9. Boundary Between the Satellite Cell Sheath and the Interstitial Connective Tissue -- 10. Quantitative Relationships Between Nerve and Satellite Cells -- 11. Origin and Development of Satellite Cells -- 12. Physiological Properties of Satellite Cells -- 13. Mitotic Activity of Satellite Cells -- 14. Phagocytic Activity of Satellite Cells -- 15. Age-Related Changes -- 16. Roles of Satellite Cells under Physiological Conditions -- 17. Communication Between Neurons and Satellite Cells -- 18. Reaction of Satellite Cells to Experimental Conditions -- 19. Reaction of Satellite Cells to Pathological Conditions -- 20. Role of Satellite Cells in Neuropathic Pain.
- Format
- e-Book
- Location
- Online
Cell Biology of Herpes Viruses
https://libcat.nshealth.ca/en/permalink/provcat41711
Klaus Osterrieder, editor.
--Cham:
Springer
, 2017.
- Available Online
- View e-Book
- Location
- Online
Herpes viruses are widely distributed in nature, causing disease in organisms as diverse as bivalves and primates, including humans. Each virus appears to have established a long-standing relationship with its host, and the viruses have the ability to manipulate and control the metabolism of host cells, as well as innate and adaptive antiviral immune responses. Herpes viruses maintain themselves within hosts in a latent state resulting in virus persistence for years--usually for the life span o…
- Available Online
- View e-Book
- Other Authors
- Osterrieder, Klaus
- Responsibility
- Klaus Osterrieder, editor
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- 2017
- Physical Description
- 1 online resource (vii, 224 pages) : 18 illus., 9 illus. in color
- Series Vol.
- 223
- Series Title
- Advances in anatomy, embryology and cell biology
- ISBN
- 9783319531687
- 9783319531670 (print ed.)
- ISSN
- 0301-5556
- Abstract
- Herpes viruses are widely distributed in nature, causing disease in organisms as diverse as bivalves and primates, including humans. Each virus appears to have established a long-standing relationship with its host, and the viruses have the ability to manipulate and control the metabolism of host cells, as well as innate and adaptive antiviral immune responses. Herpes viruses maintain themselves within hosts in a latent state resulting in virus persistence for years--usually for the life span of the hosts. Herpes viruses comprise a large number of pathogens with diverse cellular targets and biological consequences of infection. What they have in common is their structure and the fact that they establish a dormant (latent) infection in their hosts that usually persists for life. The reviews here will highlight the general principles of herpes virus infection, with equal attention to overall principle and important difference. Also, the cell type- and life-style dependent differences in the establishment and maintenance of virus persistence will be covered.
- Contents
- 1. Initial Contact: The First Steps in Herpesvirus Entry -- 2. Herpes simplex virus Membrane Fusion -- 3. Innate Immune Mechanisms and Herpes Simplex Virus Infection and Disease -- 4. The Human CMV IE1 Protein: An Offender of PML Nuclear Bodies -- 5. Herpesvirus Latency: On the Importance of Positioning Oneself -- 6. Herpesvirus Capsid Assembly and DNA Packaging -- 7. Herpesvirus Nuclear Egress -- 8. Assembly and Egress of an Alphaherpesvirus Clockwork -- 9. Interindividual Spread of Herpesviruses.
- Format
- e-Book
- Location
- Online
Cellular and Molecular Basis of Mitochondrial Inheritance : Mitochondrial Disease and Fitness
https://libcat.nshealth.ca/en/permalink/provcat44497
Peter Sutovsky, editor.
--Cham:
Springer
, c2019.
- Available Online
- View e-Book
- Location
- Online
This new volume of our successful book series Advances in Anatomy, Embryology and Cell Biology is focused on mitochondrial inheritance in humans and both vertebrate and invertrebate animals including Drosophila, C. elegans, bivalve molusc Mytilus and livestock mammals. Special consideration is given to cellular mechanisms promoting uniparental inheritance of mitochondria and mitochondrial genes, evolutionary perspectives, and biomedical and epidemiological considerations. Contributed by five di…
- Available Online
- View e-Book
- Other Authors
- Sutovsky, Peter
- Responsibility
- Peter Sutovsky, editor
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2019
- Physical Description
- 1 online resource (xi, 126 p.) : 28 illus., 24 illus. in color
- Series Vol.
- 231
- Series Title
- Advances in anatomy, embryology and cell biology
- ISBN
- 9783030045708
- 9783030045692 (Print ed.)
- 9783030045715 (Print ed.)
- ISSN
- 0301-5556
- Subjects (MeSH)
- DNA, Mitochondrial
- Extrachromosomal Inheritance
- Genes, Mitochondrial
- Mitochondria - genetics
- Specialty
- Cell Biology
- Genetics, Medical
- Molecular Medicine
- Abstract
- This new volume of our successful book series Advances in Anatomy, Embryology and Cell Biology is focused on mitochondrial inheritance in humans and both vertebrate and invertrebate animals including Drosophila, C. elegans, bivalve molusc Mytilus and livestock mammals. Special consideration is given to cellular mechanisms promoting uniparental inheritance of mitochondria and mitochondrial genes, evolutionary perspectives, and biomedical and epidemiological considerations. Contributed by five distinguished mitochondrial research teams from around the world, this volume will target a wide audience of physiologists, anatomists, cell, and developmental and evolutionary biologists, as well as physicians, veterinarians, livestock specialists and biomedical researchers.
- Contents
- Autophagosomal Sperm Organelle Clearance and mtDNA Inheritance in C. elegans -- Doubly Uniparental Inheritance of mtDNA: An Unappreciated Defiance of a General Rule -- Exogenous Factors May Differentially Influence the Selective Costs of mtDNA Mutations -- Transmission of Dysfunctional Mitochondrial DNA and Its Implications for Mammalian Reproduction -- Mitochondria Inspire a Lifestyle.
- Format
- e-Book
- Location
- Online
Chromatin Regulation of Early Embryonic Lineage Specification
https://libcat.nshealth.ca/en/permalink/provcat43373
Jason Knott, Keith Latham, editors.
--Cham:
Springer
, c2018.
- Available Online
- View e-Book
- Location
- Online
Five leaders in the field of mammalian preimplantation embryo development provide their own perspectives on key molecular and cellular processes that mediate lineage formation during the first week of life. The first cell-fate decision involves the formation of the pluripotent inner cell mass (ICM) and extraembryonic trophectoderm (TE). The second cell-fate choice encompasses the transformation of ICM into extraembryonic primitive endoderm (PE) and pluripotent epiblast. The processes, which occ…
- Available Online
- View e-Book
- Other Authors
- Knott, Jason
- Latham, Keith
- Responsibility
- Jason Knott, Keith Latham, editors
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2018
- Physical Description
- 1 online resource (vii, 78 p.) : 16 illus. in color
- Series Vol.
- 229
- Series Title
- Advances in anatomy, embryology and cell biology
- ISBN
- 9783319631875
- 9783319631868 (print ed.)
- 9783319631882 (print ed.)
- ISSN
- 0301-5556
- Subjects (MeSH)
- Cell Lineage
- Chromatin
- Embryonic Structures
- Specialty
- Cell Biology
- Embryology
- Genetics
- Abstract
- Five leaders in the field of mammalian preimplantation embryo development provide their own perspectives on key molecular and cellular processes that mediate lineage formation during the first week of life. The first cell-fate decision involves the formation of the pluripotent inner cell mass (ICM) and extraembryonic trophectoderm (TE). The second cell-fate choice encompasses the transformation of ICM into extraembryonic primitive endoderm (PE) and pluripotent epiblast. The processes, which occur during the period of preimplantation development, serve as the foundation for subsequent developmental events such as implantation, placentation, and gastrulation. The mechanisms that regulate them are complex and involve many different factors operating spatially and temporally over several days to modulate embryonic chromatin structure, impose cellular polarity, and direct distinct gene expression programs in the first cell lineages.
- Contents
- CHD1 controls cell lineage specification through zygotic genome activation -- Chromatin remodelling proteins and cell fate decisions in mammalian preimplantation development -- Transcriptional regulation and genes involved in first lineage specification during preimplantation development -- ROCK and RHO playlist for preimplantation development: Streaming to HIPPO pathway and apicobasal polarity in the first cell differentiation -- XEN and the art of stem cell maintenance - molecular mechanisms maintaining cell fate and self-renewal in extraembryonic endoderm stem (XEN) cell lines. .
- Format
- e-Book
- Location
- Online
Developmental aspects of the lymphatic vascular system
https://libcat.nshealth.ca/en/permalink/provcat33978
Friedemann Kiefer, Stefan Schulte-Merker, editors.
--Wien:
Springer
, c2014.
- Available Online
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- Location
- Online
"For decades, lymphatic vessels were considered to be of "lesser significance" than blood vessels, and the fundamental importance of lymphatic vessels for physiological tissue homeostasis and their involvement in many pathological processes have only recently been fully appreciated. It is clear by now that all higher vertebrates possess a lymphatic vessel system, and that malfunctioning of the lymphatic vasculature has severe pathophysiological consequences. Still, many central aspects of the d…
- Available Online
- View e-Book
- Other Authors
- Kiefer, Friedemann
- Schulte-Merker, Stefan
- Responsibility
- Friedemann Kiefer, Stefan Schulte-Merker, editors
- Place of Publication
- Wien
- Publisher
- Springer
- Date of Publication
- c2014
- Physical Description
- 1 online resource (xii, 204 pages)
- Series Vol.
- v. 214
- Series Title
- Advances in anatomy, embryology, and cell biology
- ISBN
- 9783709116463 (electronic bk.)
- 9783709116456
- Subjects (LCSH)
- Lymphatics - Diseases
- Lymphatics - Physiology
- Lymphatics
- Abstract
- "For decades, lymphatic vessels were considered to be of "lesser significance" than blood vessels, and the fundamental importance of lymphatic vessels for physiological tissue homeostasis and their involvement in many pathological processes have only recently been fully appreciated. It is clear by now that all higher vertebrates possess a lymphatic vessel system, and that malfunctioning of the lymphatic vasculature has severe pathophysiological consequences. Still, many central aspects of the developmental origin, growth control and regulation of lymphatic vessels are not sufficiently understood. This volume of 'Advances in anatomy, embryology, and cell biology' focuses on the lymphatic vascular system from a developmental point of view, presenting exciting recent advances in elucidating the development and molecular control of lymphatic vessels. A collection of focused reviews, written by respected experts, describes ostensively how advanced genetic models and state-of-the-art imaging are being used to decipher the action of transcriptional programs, growth factors and matrix components in the regulation of lymphatic endothelial cell behavior. A synopsis is provided for each chapter, concisely highlighting the main points"--Publisher.
- Contents
- Transcriptional control of lymphatic endothelial cell type specification -- Mechanosensing in developing lymphatic vessels -- Plasticity of airway lymphatics in development and disease -- Regulation of lymphatic vasculature by extracellular matrix -- Interplay of mechanotransduction, FOXC2, connexins and calcineurin signaling in lymphatic valve formation -- Development of secondary lymphoid organs in relation to lymphatic vasculature -- Platelets in lymph vessel development and integrity -- Interactions of immune cells and lymphatic vessels -- Lymphatic vessels in the development of tissue and organ rejection -- The role of neuropilin-1/semaphorin 3A signaling in lymphatic vessel development and maturation -- A fisheye view on lymphangiogenesis -- Visualization of lymphatic vessel development, growth and function -- Clinical disorders of primary malfunctioning of the lymphatic system.
- Format
- e-Book
- Location
- Online
Disordered Vertebral and Rib Morphology in Pudgy Mice : Structural Relationships to Human Congenital Scoliosis
https://libcat.nshealth.ca/en/permalink/provcat40320
Frederic Shapiro.
--Cham:
Springer
, c2016.
- Available Online
- View e-Book
- Location
- Online
This book presents results obtained from the whole mount preparations, radiological, and histological studies of 60 pu/pu and pu/+ mice from late embryo until 3 months of age. Most mice were in the embryo to 6 week age group where vertebral developmental changes are most marked. Although vertebral abnormalities have been identified as due to mutations in the delta-like 3 (Dll3) gene, it is evident that each mouse has differing structural abnormalities. The disorder is analogous to human congeni…
- Available Online
- View e-Book
- Author
- Shapiro, Frederic
- Responsibility
- Frederic Shapiro
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2016
- Physical Description
- 1 online resource (ix, 123 p. : 20 illus., 15 illus. in color)
- Series Vol.
- 221
- Series Title
- Advances in anatomy, embryology and cell biology
- ISBN
- 9783319431512
- 9783319431499 (print ed.)
- ISSN
- 0301-5556
- Subjects (MeSH)
- Mice - abnormalities
- Scoliosis
- Spine - abnormalities
- Abstract
- This book presents results obtained from the whole mount preparations, radiological, and histological studies of 60 pu/pu and pu/+ mice from late embryo until 3 months of age. Most mice were in the embryo to 6 week age group where vertebral developmental changes are most marked. Although vertebral abnormalities have been identified as due to mutations in the delta-like 3 (Dll3) gene, it is evident that each mouse has differing structural abnormalities. The disorder is analogous to human congenital scoliosis, a common variant of which is spondylocostal dysplasia. The histological studies presented in this book include plastic embedded sections which allow for high level resolution not only of vertebrae, intervertebral discs, and ribs but also of associated spinal cord, nerve roots and ganglia. In addition an overview of embryo and neonatal development in mouse, chick and human vertebrae is provided to better assess how and where deviant pathoanatomy occurs. The book discusses the possible variables involved in creating final deformity beyond the gene abnormality itself.
- Contents
- [publisher supplied] I. INTRODUCTION -- II. MATERIALS AND METHODS -- 1. Source, distribution, and ages of pudgy and non-affected mice. - 2. Whole mount preparations -- 3. Radiographic studies -- 4. Histologic studies -- 5. Computerized three-dimensional reconstructions -- 6. Previous studies on chick vertebral development and human congenital scoliosis -- III. RESULTS -- 1. Gross appearance -- 2. Whole mount appearances -- 3. Radiographic studies -- 4. Histology studies: vertebrae, ribs, intervertebral discs and ganglia -- 5. Computerized three-dimensional reconstructions -- 6. Chick embryo vertebral development -- 7. Radiology and histopathology of human congenital scoliosis spine -- IV. DISCUSSION -- ion -- 3. The pudgy mouse -- 4. Genetic influences on axial development; mutations identified in mouse models with vertebral deformation -- 5. Congenital scoliosis (human); its similarity with pudgy mouse vertebral abnormalities -- 6. Pathogenesis of pudgy and human congenital scoliosis based on histopathologic studies -- V. CONCLUSIONS -- 1. Implications of pudgy vertebral abnormalities for biologic research -- 2. Implications of pudgy vertebral abnormalities for clinical patient treatment. .
- Format
- e-Book
- Location
- Online
Factors Influencing Mammalian Kidney Development : Implications for Health in Adult Life
https://libcat.nshealth.ca/en/permalink/provcat28562
by Karen M. Moritz, Marelyn Wintour-Coghlan, M. Jane Black, John F. Bertram, Georgina Caruana.
--Berlin, Heidelberg:
Springer
, c2008.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Author
- Moritz, Karen M
- Responsibility
- by Karen M. Moritz, Marelyn Wintour-Coghlan, M. Jane Black, John F. Bertram, Georgina Caruana
- Place of Publication
- Berlin, Heidelberg
- Publisher
- Springer
- Date of Publication
- c2008
- Series Vol.
- 196
- Series Title
- Advances in anatomy, embryology and cell biology
- ISBN
- 9783540777687
- Subjects (MeSH)
- Kidney - growth & development
- Subjects (LCSH)
- Nephrology
- Developmental biology
- Format
- e-Book
- Location
- Online
Focus on Bio-Image Informatics
https://libcat.nshealth.ca/en/permalink/provcat40089
Winnok H. De Vos, Sebastian Munck, Jean-Pierre Timmermans, editors.
--Cham:
Springer
, c2016.
- Available Online
- View e-Book
- Location
- Online
This volume of Advances Anatomy Embryology and Cell Biology focuses on the emerging field of bio-image informatics, presenting novel and exciting ways of handling and interpreting large image data sets. A collection of focused reviews written by key players in the field highlights the major directions and provides an excellent reference work for both young and experienced researchers.
- Available Online
- View e-Book
- Other Authors
- De Vos, Winnok H
- Munck, Sebastian
- Timmermans, Jean-Pierre
- Responsibility
- Winnok H. De Vos, Sebastian Munck, Jean-Pierre Timmermans, editors
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2016
- Physical Description
- 1 online resource (x, 272 p. : 85 illus., 81 illus. in color)
- Series Vol.
- 219
- Series Title
- Advances in anatomy, embryology and cell biology
- ISBN
- 9783319285498
- 9783319285474 (print ed.)
- ISSN
- 0301-5556
- Abstract
- This volume of Advances Anatomy Embryology and Cell Biology focuses on the emerging field of bio-image informatics, presenting novel and exciting ways of handling and interpreting large image data sets. A collection of focused reviews written by key players in the field highlights the major directions and provides an excellent reference work for both young and experienced researchers.
- Contents
- Seeing is believing, quantifying is convincing: Computational image analysis in biology -- Image degradation in microscopic images: Avoidance, artifacts and solutions -- Transforms and operators for directional bioimage analysis: A survey -- Analyzing protein clusters on the plasma membrane: Application of spatial statistical analysis methods on super-resolution microscopy images -- Image informatics strategies for deciphering neuronal connectivity -- Integrated high-content quantification of intracellular ROS levels and mitochondrial morphofunction -- KNIME for open-source BioImage analysis: A Tutorial -- Segmenting and tracking multiple dividing targets using ilastik -- Challenges and benchmarks in BioImage analysis -- BioImage informatics for big data.
- Format
- e-Book
- Location
- Online
Footmarks of Innate Immunity in the Ovary and Cytokeratin-Positive Cells as Potential Dendritic Cells
https://libcat.nshealth.ca/en/permalink/provcat30455
by Katharina Spanel-Borowski.
--Berlin, Heidelberg:
Springer-Verlag
, c2011.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Author
- Spanel-Borowski, Katharina
- Responsibility
- by Katharina Spanel-Borowski
- Place of Publication
- Berlin, Heidelberg
- Publisher
- Springer-Verlag
- Date of Publication
- c2011
- Series Vol.
- 209
- Series Title
- Advances in anatomy, embryology and cell biology
- ISBN
- 9783642160776
- Subjects (MeSH)
- Immunity, Innate
- Dendritic Cells - immunology
- Keratins - immunology
- Ovary - immunology
- Subjects (LCSH)
- Cytology
- Immunology
- Reproductive medicine
- Format
- e-Book
- Location
- Online
Functional Anatomy of the Sleep-Wakefulness Cycle : Wakefulness
https://libcat.nshealth.ca/en/permalink/provcat30036
by Fernando Reinoso-Suárez, Isabel de Andrés, Miguel Garzón.
--Berlin, Heidelberg:
Springer-Verlag
, c2011.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Author
- Reinoso-Suárez, Fernando
- Other Authors
- de Andrés, Isabel
- Garzón, Miguel
- Responsibility
- by Fernando Reinoso-Suárez, Isabel de Andrés, Miguel Garzón
- Place of Publication
- Berlin, Heidelberg
- Publisher
- Springer-Verlag
- Date of Publication
- c2011
- Series Vol.
- 208
- Series Title
- Advances in anatomy, embryology and cell biology
- ISBN
- 9783642146268
- Subjects (MeSH)
- Brain - anatomy & histology
- Brain - physiology
- Sleep - physiology
- Wakefulness - physiology
- Subjects (LCSH)
- Neurosciences
- Physiology
- Format
- e-Book
- Location
- Online
Metallothioneins in Normal and Cancer Cells
https://libcat.nshealth.ca/en/permalink/provcat40043
Piotr Dziegiel, Bartosz Pula, Christopher Kobierzycki, Mariusz Stasiolek, Marzenna Podhorska-Okolow.
(1st ed.)
--Cham:
Springer
, c2016.
- Available Online
- View e-Book
- Location
- Online
This book describes the structures of Metallothionein (MT) family members and the cellular functions of MT-1, MT-2 and MT-4 isoforms, as well as provides insights into divergent biological roles of MT-3. The authors explain the involvement of MT molecules in various processes related to carcinogenesis, including an organ-specific presentation of current data concerning their potential impact on the progression of various tumors and the regulatory role of MT family members in the function of the…
- Available Online
- View e-Book
- Author
- Dziegiel, Piotr
- Responsibility
- Piotr Dziegiel, Bartosz Pula, Christopher Kobierzycki, Mariusz Stasiolek, Marzenna Podhorska-Okolow
- Edition
- 1st ed.
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2016
- Physical Description
- 1 online resource (xii, 117 p. : 13 illus., 11 illus. in color)
- Series Vol.
- 218
- Series Title
- Advances in anatomy, embryology and cell biology
- ISBN
- 9783319274720
- 9783319274713 (print ed.)
- ISSN
- 0301-5556
- Subjects (MeSH)
- Metallothionein - genetics
- Metallothionein - physiology
- Neoplasms - etiology
- Neoplasms - genetics
- Neoplasms - pathology
- Abstract
- This book describes the structures of Metallothionein (MT) family members and the cellular functions of MT-1, MT-2 and MT-4 isoforms, as well as provides insights into divergent biological roles of MT-3. The authors explain the involvement of MT molecules in various processes related to carcinogenesis, including an organ-specific presentation of current data concerning their potential impact on the progression of various tumors and the regulatory role of MT family members in the function of the immune system.
- Contents
- Introduction -- Metallothioneins: structure and functions -- Metallothionein-3 -- The role of metallothioneins in carciogenesis -- Metallothioneins and immune function.
- Format
- e-Book
- Location
- Online
Molecular and Functional Insights Into the Pulmonary Vasculature
https://libcat.nshealth.ca/en/permalink/provcat42841
Kaushik Parthasarathi, editor.
--Cham:
Springer
, c2018.
- Available Online
- View e-Book
- Location
- Online
This book provides a comprehensive review of the structure, function and pathophysiology of the pulmonary vasculature. Emerging evidence reveals the multifaceted roles played by the pulmonary vasculature. To reflect those roles, the individual chapters address topics ranging from pulmonary blood vessel development to vascular endothelial apoptosis, and delve deeply into our current understanding of various aspects of the pulmonary vasculature.
- Available Online
- View e-Book
- Other Authors
- Parthasarathi, Kaushik
- Responsibility
- Kaushik Parthasarathi, editor
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2018
- Physical Description
- 1 online resource (vi, 86 p.) : 7 illus., 6 illus. in color
- Series Vol.
- 228
- Series Title
- Advances in anatomy, embryology and cell biology
- ISBN
- 9783319684833
- 9783319684826 (print ed.)
- 9783319684840 (print ed.)
- ISSN
- 0301-5556
- Specialty
- Pulmonary Medicine
- Abstract
- This book provides a comprehensive review of the structure, function and pathophysiology of the pulmonary vasculature. Emerging evidence reveals the multifaceted roles played by the pulmonary vasculature. To reflect those roles, the individual chapters address topics ranging from pulmonary blood vessel development to vascular endothelial apoptosis, and delve deeply into our current understanding of various aspects of the pulmonary vasculature.
- Contents
- Transcription Factors Regulating Embryonic Development of Pulmonary Vasculature -- Regulation of Intercellular Junctions in the Pulmonary Vasculature -- Mitochondria-dependent Signaling in the Pulmonary Vasculature -- Leukocyte-Endothelial Interactions in the Pulmonary Vasculature -- Apoptotic Mechanisms in the Pulmonary Vasculature.
- Format
- e-Book
- Location
- Online
Neuroanatomy and pathology of sporadic Alzheimer's Disease
https://libcat.nshealth.ca/en/permalink/provcat33646
Heiko Braak, Kelly Del Tredici.
--Cham, Switzerland:
Springer
, c2015.
- Available Online
- View e-Book
- Location
- Online
As indicated by its title, this monograph deals chiefly with morphologically recognizable deviations from the normal anatomical condition of the human CNS. The AD-associated pathology is illustrated from its beginnings (sometimes even in childhood) to its final form, which is reached late in life. The AD process commences much earlier than the clinically recognizable phase of the disorder, and its timeline includes an extended preclinical phase. The further the pendulum swings away from the sym…
- Available Online
- View e-Book
- Author
- Braak, Heiko
- Other Authors
- Del Tredici, Kelly
- Responsibility
- Heiko Braak, Kelly Del Tredici
- Place of Publication
- Cham, Switzerland
- Publisher
- Springer
- Date of Publication
- c2015
- Physical Description
- 1 online resource (xi, 162 pages)
- Series Vol.
- 215
- Series Title
- Advances in anatomy, embryology, and cell biology
- ISBN
- 9783319126791 (electronic bk.)
- 9783319126784
- Subjects (MeSH)
- Alzheimer Disease - pathology
- Subjects (LCSH)
- Alzheimer's disease
- Abstract
- As indicated by its title, this monograph deals chiefly with morphologically recognizable deviations from the normal anatomical condition of the human CNS. The AD-associated pathology is illustrated from its beginnings (sometimes even in childhood) to its final form, which is reached late in life. The AD process commences much earlier than the clinically recognizable phase of the disorder, and its timeline includes an extended preclinical phase. The further the pendulum swings away from the symptomatic final stages towards the early pathology, the more obvious the lesions become, although from a standpoint of severity they are more unremarkable and thus frequently overlooked during routine neuropathological assessment. For this reason, the authors deal with the hallmark lesions in the early phases of the AD process in considerable detail.
- Contents
- 1. Prologue -- 2. Introduction -- 3. Basic Organization of Non-thalamic Nuclei with Diffuse Cortical Projections -- 4. Microtubules and the Protein Tau -- 5. Early Presymptomatic Stages -- 6. Basic Organization of Territories That Become Sequentially Involved After Initial Involvement of Brainstem Nuclei with Diffuse Projections -- 7. The Pattern of Cortical Lesions in Preclinical Stages -- 8. Alzheimer-Associated Pathology in the Extracellular Space -- 9. The Pattern of Lesions During the Transition to the Symptomatic Phase and in Fully Developed Alzheimer’s Disease -- 10. Final Considerations -- 11. Technical Addendum -- References.
- Format
- e-Book
- Location
- Online
Novel Insights in the Neurochemistry and Function of Pulmonary Sensory Receptors
https://libcat.nshealth.ca/en/permalink/provcat31134
Inge Brouns ... [et al.].
--Berlin, Heidelberg:
Springer
, c2012.
- Available Online
- View e-Book
- Location
- Online
Airway sensory nerve terminals are tailored to detect changes in the physical and chemical environment, thereby supplying local pulmonary information to the central nervous system. Since most intrapulmonary nerve terminals arise from fibres travelling in the vagal nerve, the classification of sensory airway receptors' is largely based on their action potential characteristics, electrophysiologically registered from the vagal nerve. However, the architecture of airways and lungs makes it nearly…
- Available Online
- View e-Book
- Author
- Brouns, Inge
- Responsibility
- Inge Brouns ... [et al.]
- Place of Publication
- Berlin, Heidelberg
- Publisher
- Springer
- Date of Publication
- c2012
- Physical Description
- 1 online resource (xii, 118 p. : 23 ill., 21 ill. in color)
- Series Vol.
- 211
- Series Title
- Advances in anatomy, embryology and cell biology
- ISBN
- 9783642227721
- Subjects (MeSH)
- Immunohistochemistry
- Lung - innervation
- Muscle, Smooth - innervation
- Sensory Receptor Cells - physiology
- Subjects (LCSH)
- Human physiology
- Neurochemistry
- Pneumonology
- Abstract
- Airway sensory nerve terminals are tailored to detect changes in the physical and chemical environment, thereby supplying local pulmonary information to the central nervous system. Since most intrapulmonary nerve terminals arise from fibres travelling in the vagal nerve, the classification of sensory airway receptors' is largely based on their action potential characteristics, electrophysiologically registered from the vagal nerve. However, the architecture of airways and lungs makes it nearly impossible to functionally locate the exact nerve terminals that are responsible for the transduction of a particular intrapulmonary stimulus. In this monograph we focus on three sensory receptor end organs in lungs that are currently morphologically well-characterised: smooth muscle-associated airway receptors (SMARs), neuroepithelial bodies (NEBs) and visceral pleura receptors (VPRs). Unravelling the main functional morphological and neurochemical characteristics of these sensory receptors using advanced immunohistochemistry and confocal microscopy has already allowed us to draw important conclusions about their potential function(s). The current development of ex vivo lung models for the selective identification of SMARs, NEBs and VPRs using vital staining will certainly facilitate direct physiological studies of these morphologically well-characterised airway receptors, since these models allow direct live studies of their functional properties.
- Contents
- Sensory Nerve Terminals in Intrapulmonary Airways and Lungs -- Electrophysiologically Identified Airway Receptors: Main Characteristics -- Morphology and Location of Electrophysiologically Identified Sensory Airway Receptors -- The Neurochemical Coding of Airway Afferents -- Morphologically Identified Sensory Receptor End-Organs in the Airways, Lungs and Visceral Pleura -- In Situ Functional Imaging of Sensory Receptors in Lung Models -- Concluding Remarks and Future Prospects.
- Format
- e-Book
- Location
- Online
Physical rehabilitation of paralysed facial muscles : functional and morphological correlates
https://libcat.nshealth.ca/en/permalink/provcat25700
Angelov, Doychin N.
--Heidelberg, Germany:
Springer
, c2011.
- Call Number
- WL 330 A584p 2011
- Location
- Halifax Infirmary
- Call Number
- WL 330 A584p 2011
- Author
- Angelov, Doychin N
- Place of Publication
- Heidelberg, Germany
- Publisher
- Springer
- Date of Publication
- c2011
- Physical Description
- 143 p.
- Series Vol.
- 210
- Series Title
- Advances in anatomy, embryology and cell biology
- ISBN
- 9783642181191
- Subjects (MeSH)
- Electric Stimulation Therapy - methods
- Facial Muscles
- Facial Nerve Injuries
- Facial Paralysis - therapy
- Massage - methods
- Format
- Book
- Location
- Halifax Infirmary
- Copies
- 1
- Loan Period
- 3 weeks
The Pulvinar Thalamic Nucleus of Non-Human Primates : Architectonic and Functional Subdivisions
https://libcat.nshealth.ca/en/permalink/provcat43209
Ricardo Gattass, Juliana G.M. Soares, Bruss Lima.
--Cham:
Springer
, c2018.
- Available Online
- View e-Book
- Location
- Online
This book discusses the hypothesis that the primate pulvinar contains an original scaffold which is derived from cytoarchitectural markers and specific protein distributions. Thereafter, along primate evolution, different selective pressures acted in order to shape and fine-tune the connectivity of the pulvinar with specific regions of the neocortex. This divergence created, among other things, the different sets of retinotopic map representations in the pulvinar nucleus depending on functional…
- Available Online
- View e-Book
- Author
- Gattass, Ricardo
- Other Authors
- Soares, Juliana G.M.
- Lima, Bruss
- Responsibility
- Ricardo Gattass, Juliana G.M. Soares, Bruss Lima
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2018
- Physical Description
- 1 online resource (vii, 66 p.) : 29 illus., 9 illus. in color
- Series Vol.
- 225
- Series Title
- Advances in anatomy, embryology and cell biology
- ISBN
- 9783319700465
- 9783319700458 (print ed.)
- 9783319700472 (print ed.)
- ISSN
- 0301-5556
- Subjects (MeSH)
- Biological Evolution
- Primates
- Pulvinar
- Specialty
- Neurology
- Physiology
- Zoology
- Abstract
- This book discusses the hypothesis that the primate pulvinar contains an original scaffold which is derived from cytoarchitectural markers and specific protein distributions. Thereafter, along primate evolution, different selective pressures acted in order to shape and fine-tune the connectivity of the pulvinar with specific regions of the neocortex. This divergence created, among other things, the different sets of retinotopic map representations in the pulvinar nucleus depending on functional and behavioral requirements of each species. The pulvinar, the largest nucleus of the primate thalamus, has extensive and reciprocal connections with several areas of the neocortex. These input-output loops suggest that the pulvinar may regulate the flow of information within and between cortical areas in a highly dynamic fashion. Therefore, understanding the anatomical subdivisions within the pulvinar, and its connectivity with the cortex, is paramount to understanding pulvinar physiological function. However, there is a stark contrast regarding the way that the pulvinar is subdivided depending on the technique employed. Cytoarchitectural and immunohistochemical methods reveal a very similar pattern of pulvinar subdivision across Old- and New-World monkeys. On the other hand, electrophysiological and connectivity studies expose clear discrepancies in pulvinar organization across primate evolution.
- Contents
- Chapter 1: introduction -- Chapter 2: Cytoarchitecture and myeloarchitecture of the pulvinar -- Chapter 3: Chemoarchitecture of the pulvinar -- Chapter 4: Visual map representations in the primate pulvinar -- Chapter 5: Connectivity of the pulvinar -- Chapter 6: Reestablishing the chemoarchitectural borders based on electrophysiological and connectivity data -- Chapter 7: Visual topography of the pulvinar projection zones -- Chapter 8: Comparative pulvinar organization across different primate species -- Chapter 9: Response properties of pulvinar neurons studied with single unit electrophysiological recordings -- Chapter 10: Modulation of pulvinar neuronal activity by arousal -- Chapter 11: Gaba inactivation of the pulvinar -- Chapter 12: The role of the pulvinar in spatial visual attention.
- Format
- e-Book
- Location
- Online
The Role of Heat Shock Proteins in Reproductive System Development and Function
https://libcat.nshealth.ca/en/permalink/provcat41667
Daniel J. MacPhee, editor.
--Cham:
Springer
, 2017.
- Available Online
- View e-Book
- Location
- Online
Due to the paucity of reviews on this subject, this volume aims to be timely and promote additional basic and translational research on these proteins in reproductive system development and function within the fields of Anatomy, Embryology and Cell Biology. The breadth of the work being conducted within Reproduction is exemplified by the contributors to this series who will provide reviews on: Grp78 roles in female reproduction, small heat shock proteins/co-chaperones as players in uterine smoo…
- Available Online
- View e-Book
- Other Authors
- MacPhee, Daniel J
- Responsibility
- Daniel J. MacPhee, editor
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- 2017
- Physical Description
- 1 online resource (ix, 155 pages) : 59 illus., 14 illus. in color
- Series Vol.
- 222
- Series Title
- Advances in anatomy, embryology and cell biology
- ISBN
- 9783319514093
- 9783319514086 (print ed.)
- ISSN
- 0301-5556
- Subjects (MeSH)
- Heat-Shock Proteins
- Reproductive Physiological Phenomena
- Abstract
- Due to the paucity of reviews on this subject, this volume aims to be timely and promote additional basic and translational research on these proteins in reproductive system development and function within the fields of Anatomy, Embryology and Cell Biology. The breadth of the work being conducted within Reproduction is exemplified by the contributors to this series who will provide reviews on: Grp78 roles in female reproduction, small heat shock proteins/co-chaperones as players in uterine smooth muscle function, the role of heat shock proteins in sperm function and maternal contribution to oogenesis and early embryogenesis, heat shock factors and testes development, HSP90 in ovarian biology and pathology, and the role of HSP70 in regulation of autophagy in pregnancy and parturition.
- Contents
- 1. Heat Shock Proteins and maternal contribution to oogenesis and early embryogenesis -- 2. The unmysterious roles of HSP90: Ovarian biology and autoantibodies -- 3. The role of heat shock factors in mammalian spermatogenesis -- 4. Heat shock protein A2 (HSPA2): Regulatory roles in germ cell development and sperm function -- 5. The potential functions of small heat shock proteins in the uterine musculature during pregnancy -- 6. The role of HSP70 in the regulation of autophagy in gametogenesis, pregnancy and parturition -- 7. Roles of Grp78 in female mammalian reproduction.
- Format
- e-Book
- Location
- Online
Sensing the Environment : Regulation of Local and Global Homeostasis by the Skin's Neuroendocrine System
https://libcat.nshealth.ca/en/permalink/provcat31114
Andrzej T. Slominski ... [et al.].
--Berlin, Heidelberg:
Springer
, c2012.
- Available Online
- View e-Book
- Location
- Online
The skin, the body's largest organ, is strategically located at the interface with the external environment where it detects, integrates and responds to a diverse range of stressors, including solar radiation. It has already been established that the skin is an important peripheral neuroendocrine-immune organ that is closely networked with central regulatory systems. These capabilities contribute to the maintenance of peripheral homeostasis. Specifically, epidermal and dermal cells produce and …
- Available Online
- View e-Book
- Other Authors
- Slominski, Andrzej T
- Responsibility
- Andrzej T. Slominski ... [et al.]
- Place of Publication
- Berlin, Heidelberg
- Publisher
- Springer
- Date of Publication
- c2012
- Physical Description
- 1 online resource (xv, 115 p. : 23 ill., 17 ill. in color)
- Series Vol.
- 212
- Series Title
- Advances in anatomy, embryology and cell biology
- ISBN
- 9783642196836
- Subjects (LCSH)
- Neurosciences
- Dermatology
- Endocrinology
- Abstract
- The skin, the body's largest organ, is strategically located at the interface with the external environment where it detects, integrates and responds to a diverse range of stressors, including solar radiation. It has already been established that the skin is an important peripheral neuroendocrine-immune organ that is closely networked with central regulatory systems. These capabilities contribute to the maintenance of peripheral homeostasis. Specifically, epidermal and dermal cells produce and respond to classical stress neurotransmitters, neuropeptides and hormones, production which is stimulated by ultraviolet radiation (UVR), biological factors (infectious and non-infectious) and other physical and chemical agents. Examples of local biologically active products are cytokines, biogenic amines (catecholamines, histamine, serotonin and N-acetyl-serotonin), melatonin, acetylocholine, neuropeptides including pituitary (proopiomelanocortin-derived ACTH, b-endorphin or MSH peptides, thyroid stimulating hormone) and hypothalamic (corticotropin-releasing factor and related urocortins, thyroid-releasing hormone) hormones, as well as enkephalins and dynorphins, thyroidá hormones, steroids (glucocorticoids, mineralocorticoids, sex hormones, 7-þ steroids), secosteroids, opioids and endocannabinoids. The production of these molecules is hierarchical, organized along the algorithms of classical neuroendocrine axes such as the hypothalamic pituitary adrenal axis (HPA), hypothalamic-thyroid axis (HPT), serotoninergic, melatoninergic, catecholaminergic, cholinergic, steroid/secosteroidogenic, opioid and endocannabinoid systems. Disruptions of these axes or of communication between them may lead to skin and/or systemic diseases. These local neuroendocrine networks also serve to limit the effect of noxious environmental agents to preserve local and consequently global homeostasis. Moreover, the skin-derived factors/systems can also activate cutaneous nerve endings to alert the brain to changes in the epidermal or dermal environments, or alternatively to activate other coordinating centers by direct (spinal cord) neurotransmission without brain involvement. Furthermore, rapid and reciprocal communications between epidermal and dermal and adnexal compartments are also mediated by neurotransmission including antidromic modes of conduction. Lastly, skin cells and the skin as an organ coordinate and/or regulate not only peripheral but also global homeostasis.
- Contents
- Introduction -- Biogenic amines in the skin -- Melatoninergic system in the skin -- Cutaneous cholinergic system -- Corticotropin signaling system in the skin -- Steroidogenesis in the skin -- Equivalent of hypothalamo-pituitary adrenal axis in the skin -- Cutaneous secosteroidal system -- Equivalent of hypthalamic-pituitary-thyroid axis -- Cutaneous opioid system -- Cutaneous endocannabinoid system -- Perspectives -- References.
- Format
- e-Book
- Location
- Online
Sperm Acrosome Biogenesis and Function During Fertilization
https://libcat.nshealth.ca/en/permalink/provcat40170
Mariano G. Buffone, editor.
--Cham:
Springer
, c2016.
- Available Online
- View e-Book
- Location
- Online
Over the last decades, acrosomal exocytosis (also called the "acrosome reaction") has been recognized as playing an essential role in fertilization. Secretion of this granule is an absolute requirement for physiological fertilization. In recent years, the study of mammalian acrosomal exocytosis has yielded some major advances that challenge the long-held, general paradigms in the field. Principally, the idea that sperm must be acrosome-intact to bind to the zona pellucida of unfertilized eggs, …
- Available Online
- View e-Book
- Other Authors
- Buffone, Mariano G
- Responsibility
- Mariano G. Buffone, editor
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2016
- Physical Description
- 1 online resource (vii, 172 p. : 19 illus., 16 illus. in color)
- Series Vol.
- 220
- Series Title
- Advances in anatomy, embryology and cell biology
- ISBN
- 9783319305677
- 9783319305653 (print ed.)
- ISSN
- 0301-5556
- Subjects (MeSH)
- Acrosome - physiology
- Exocytosis - physiology
- Fertilization - physiology
- Abstract
- Over the last decades, acrosomal exocytosis (also called the "acrosome reaction") has been recognized as playing an essential role in fertilization. Secretion of this granule is an absolute requirement for physiological fertilization. In recent years, the study of mammalian acrosomal exocytosis has yielded some major advances that challenge the long-held, general paradigms in the field. Principally, the idea that sperm must be acrosome-intact to bind to the zona pellucida of unfertilized eggs, based largely on in vitro fertilization studies of mouse oocytes denuded of the cumulus oophorus, has been overturned by experiments using state-of-the-art imaging of cumulus-intact oocytes and fertilization experiments where eggs were reinseminated by acrosome-reacted sperm recovered from the perivitelline space of zygotes. From a molecular point of view, acrosome exocytosis is a synchronized and tightly regulated process mediated by molecular mechanisms that are homologous to those reported in neuroendocrinal cell secretions. The authors provide a broader perspective, focusing on a limited number of important topics that are essential for understanding the molecular mechanisms governing this step in the fertilization process. They also discuss molecular aspects such as the signaling pathways leading to exocytosis, including the participation of ion channels, lipids, the fusion machinery proteins and the actin cytoskeleton as well as cellular aspects such as the site of acrosomal exocytosis and the use of gene-manipulated animals to study this process.
- Contents
- 1. The Acrosome Reaction: A Historical Perspective -- 2. The Acrosomal Matrix -- 3. Role of Ion Channels in the Sperm Acrosome Reaction -- 4. The Molecules of Sperm Exocytosis -- 5. Sperm Capacitation and Acrosome Reaction in Mammalian Sperm -- 6. Lipid Regulation of Acrosome Exocytosis -- 7. Role of Actin Cytoskeleton During Mammalian Sperm Acrosomal Exocytosis -- 8. Site of Mammalian Sperm Acrosome Reaction -- 9. Acrosome Reaction as a Preparation for Gamete Fusion.
- Format
- e-Book
- Location
- Online
Stimulation of trigeminal afferents improves motor recovery after facial nerve injury : functional, electrophysiological and morphological proofs : with 15 figures
https://libcat.nshealth.ca/en/permalink/provcat32514
Emmanouil Skouras, Stoyan Pavlov, Habib Bendella ... [et al.], authors.
--Berlin, Heidelberg:
Springer
, c2013.
- Available Online
- View e-Book
- Location
- Online
Its is commonly known that the recovery of mimic functions after facial nerve injury is poor: a successful regrowth of the lesioned axons to their muscle targets is compromised by (i) poor navigation of the growth cones and excessive collateral axonal branching, (ii) abnormal exchange of nerve impulses between adjacent regrowing axons and (iii) insufficient synaptic input to the facial neuronal cell bodies in the brainstem. As a result, axotomized motoneurons become hyperexcitable and unable to…
- Available Online
- View e-Book
- Author
- Skouras, Emmanouil
- Responsibility
- Emmanouil Skouras, Stoyan Pavlov, Habib Bendella ... [et al.], authors
- Place of Publication
- Berlin, Heidelberg
- Publisher
- Springer
- Date of Publication
- c2013
- Physical Description
- 1 online resource (xv, 110 p. : 15 ill., 12 ill. in color)
- Series Vol.
- 213
- Series Title
- Advances in anatomy, embryology and cell biology
- ISBN
- 9783642333118
- Subjects (MeSH)
- Facial Nerve - surgery
- Trigeminal Nerve - physiology
- Subjects (LCSH)
- Neurosciences
- Neurosurgery
- Abstract
- Its is commonly known that the recovery of mimic functions after facial nerve injury is poor: a successful regrowth of the lesioned axons to their muscle targets is compromised by (i) poor navigation of the growth cones and excessive collateral axonal branching, (ii) abnormal exchange of nerve impulses between adjacent regrowing axons and (iii) insufficient synaptic input to the facial neuronal cell bodies in the brainstem. As a result, axotomized motoneurons become hyperexcitable and unable to discharge. Since the improvement of growth cone navigation and the reduction of the ephaptic cross-talk between axons both turn out be impossible at present, the authors focused their efforts on the third detrimental component and proposed that an intensification of the trigeminal input to the axotomized and electrophysiologically silent facial motoneurons might improve the specificity of reinnervation. To test their hypothesis, they compared behavioral, electrophysiological and morphological parameters after single reconstructive surgery on the facial nerve (or its buccal branch) with those obtained after identical facial nerve surgery but combined with indirect (removal of the contralateral infraorbital nerve, ION) or direct (massage of the mimic muscles) stimulation of the ipsilateral ION. They found that in all cases any trigeminal stimulation was beneficial for the outcome by improving both the quality of target reinnervation (reduced polyinnervation of the motor endplates) and the recovery of vibrissal motor performance (as judged by video-based motion analysis). Based on these results, the authors conclude that trigeminal stimulation is a non-invasive procedure with immediate potential for clinical rehabilitation following facial nerve reconstruction.
- Contents
- First major set: mild indirect stimulation of the trigeminal afferents after combined surgery on the infraorbital and facial nerves by removal (clipping) of the contralateral vibrissal hairs.-Second major set: intensive indirect stimulation of the trigeminal afferents after facial nerve surgery by extcision of the contralateral infraorbital nerve -- Third major set: direct stimulation of the trigeminal and facial nerves after facial nerve surgery by massage of the vibrissal muscles .- Fourth major set: direct stimulation of the trigeminal and facial nerves after facial nerve surgery by application of electric current to the vibrissal muscles.- RESULTS.- Mild indirect stimulation of the trigeminal afferents after combined surgery on the infraorbital and facial nerves by removal of the contralateralvibrissal hairs improves vibrissal function.-Intensive indirect stimulation of the trigeminal afferents by excision of the contralateral ION attenuates the degree of collateral axonal branching and improves the accuracy of muscle reinnervation.- Direct stimulation of the trigeminal and facial nerves by massage of the vibrissal muscles improves the quality of target reinnervation and promotes full recovery of whisking function.- Direct stimulation of the trigeminal and facial nerves by electric current to the vibrissal muscles fails to improve quality of target reinnervation and does not promoterecovery of vibrissal function.- DISCUSSION.- Mild indirect stimulation of the trigeminal afferents by removal of the contralateral vibrissal hairs has a beneficial effect on motor recovery.- Beneficial effect of the intensive indirect stimulation of thetrigeminal afferents by excision of the contralateral ION.- Complete recovery of motor function after direct stimulation of the trigeminal and facial nerves by massage of the vibrissal muscles.- Deleterious effect of the direct stimulation of the trigeminal and facial nerves by application of electric current to the vibrissal muscles .- conclusion -- Conclusion -- References -- Index.
- Format
- e-Book
- Location
- Online
