Advances in Biology and Treatment of Glioblastoma
https://libcat.nshealth.ca/en/permalink/provcat41809
Kumaravel Somasundaram, editor.
--Cham:
Springer
, 2017.
- Available Online
- View e-Book
- Location
- Online
This volume covers the most important areas of glioblastoma: surgical resection, molecular pathology, targeted therapies, cancer stem cells, the role of DNA methylation, targeted sequencing for personalized therapy, animal models and advances in pediatric glioblastoma. Chapter authors are junior and senior investigators, who are well established in their particular areas and include neurosurgeons, neuropathologists, neurooncologists and basic scientists.
- Available Online
- View e-Book
- Other Authors
- Somasundaram, Kumaravel
- Responsibility
- Kumaravel Somasundaram, editor
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- 2017
- Physical Description
- 1 online resource (ix, 272 pages) : 24 illus. in color
- Series Title
- Current cancer research
- ISBN
- 9783319568201
- 9783319568195 (print ed.)
- ISSN
- 2199-2584
- Subjects (MeSH)
- Glioblastoma - pathology
- Neurosurgical Procedures - methods
- Abstract
- This volume covers the most important areas of glioblastoma: surgical resection, molecular pathology, targeted therapies, cancer stem cells, the role of DNA methylation, targeted sequencing for personalized therapy, animal models and advances in pediatric glioblastoma. Chapter authors are junior and senior investigators, who are well established in their particular areas and include neurosurgeons, neuropathologists, neurooncologists and basic scientists.
- Contents
- 1. Maximal Safe Resection in Glioblastoma: Use of Adjuncts -- 2. Molecular Pathology of Glioblastoma- an Update -- 3. Current Therapies and Future Directions in Treatment of Glioblastoma -- 4. Recent Advances for Targeted Therapies in Glioblastoma -- 5. Targeting EGFR in Glioblastoma: Molecular Biology and Current Understanding -- 6. Radiogenomics & Histomics in Glioblastoma: The Promise of Linking Image-derived Phenotype with Genomic Information -- 7. Next-generation Sequencing in Glioblastoma Personalized Therapy -- 8. Glioma Stem-like Cells in Tumor Growth and Therapy Resistance of Glioblastoma -- 9. Animal Models in Glioblastoma: Use in Biology and Developing Therapeutic Strategies -- 10. Pediatric High Grade Glioma.
- Format
- e-Book
- Location
- Online
Advances in tumor immunology and immunotherapy
https://libcat.nshealth.ca/en/permalink/provcat33290
Joseph D. Rosenblatt, Eckhard R. Podack, Glen N. Barber, Augusto Ochoa, editors.
--New York:
Springer
, c2014.
- Available Online
- View e-Book
- Location
- Online
Recent advances in understanding of fundamental immunology have created new insights into the dynamic interactions between tumors and the immune system. This includes new understanding of T- and B-cell interaction, immune inhibitory mechanisms including the biology of T regulatory cells, myeloid suppressor cells, and dendritic cell subsets. Enhanced understanding of mechanisms underlying T-cell anergy such as arginine deprivation, immunosuppressive cytokines, defective innate and interferon res…
- Available Online
- View e-Book
- Other Authors
- Rosenblatt, Joseph D
- Responsibility
- Joseph D. Rosenblatt, Eckhard R. Podack, Glen N. Barber, Augusto Ochoa, editors
- Place of Publication
- New York
- Publisher
- Springer
- Date of Publication
- c2014
- Physical Description
- 1 online resource (ix, 371 pages)
- Series Title
- Current cancer research
- ISBN
- 9781461488095 (electronic bk.)
- 9781461488088
- Subjects (MeSH)
- Antigens, Neoplasm - immunology
- Neoplasms - immunology
- Neoplasms - therapy
- T-Lymphocytes, Cytotoxic - immunology
- Immunotherapy - methods
- Subjects (LCSH)
- Tumors - Immunological aspects
- Cancer - Immunological aspects
- Antigens, Neoplasm - immunology
- Neoplasms - therapy
- T-Lymphocytes, Cytotoxic - immunology
- Cancer - Immunotherapy
- Neoplasms - Immunology
- Abstract
- Recent advances in understanding of fundamental immunology have created new insights into the dynamic interactions between tumors and the immune system. This includes new understanding of T- and B-cell interaction, immune inhibitory mechanisms including the biology of T regulatory cells, myeloid suppressor cells, and dendritic cell subsets. Enhanced understanding of mechanisms underlying T-cell anergy such as arginine deprivation, immunosuppressive cytokines, defective innate and interferon response pathways, and NKG2D downregulation have all provided new insight into suppression of anti-tumors.
- Contents
- Part I. Immune Activation, Suppression and Manipulation of the Immune Antitumor Response -- Myeloid-Derived Suppressor Cells in Cancer -- The Role of B Cells in Shaping the Antitumor Immune Response -- Heat-Shock Protein-Based Cancer Immunotherapy -- Activation of NK Cell Responses and Immunotherapy of Cancer -- Induction of Tumor Immunity by Targeted Inhibition of Nonsense-Mediated mRNA Decay -- Employing T Cell Homeostasis as an Antitumor Strategy -- Adoptive Cell Therapy of Systemic Metastases Using erbB-2-Specific T Cells Redirected with a Chimeric Antibody-Based Receptor -- Part II. Evolving Clinical Immunotherapeutic Strategies -- Immunotherapy in Renal Cell Carcinoma -- Adoptive T-Cell Transfer as a Clinical Antitumor Strategy for Hematologic Malignancies -- Bifunctional Antibodies: Preclinical and Clinical Applications -- Clinical Development of Antibody-Fusion Proteins for Cancer Therapy -- Immunologic Outcomes of Allogeneic Stem Cell Transplantation: Graft-Versus-Host and Graft-Versus-Leukemia Responses and Implications for Future Therapy -- The Immune System in Head and Neck Squamous Cell Carcinoma: Interactions and Therapeutic Opportunities -- T Cell Co-regulatory Signals and Their Role in Cancer Therapy -- Assessment of Immune Response in Biotherapy Trials and Clinical Endpoints.
- Format
- e-Book
- Location
- Online
Asbestos and Mesothelioma
https://libcat.nshealth.ca/en/permalink/provcat41725
Joseph R. Testa, editor.
--Cham:
Springer
, 2017.
- Available Online
- View e-Book
- Location
- Online
This volume is comprised of a multidisciplinary assessment of the interplay between asbestos and cancer as well as new research about the biology and treatment of malignant mesothelioma. Chapters on the various types of asbestos and other mineral fibers, epidemiology, history and future of asbestos-related diseases are included. Other reviews present new information about the role of asbestos-related inflammation and genetic factors, including the role of inherited mutations of BAP1, in mesothe…
- Available Online
- View e-Book
- Other Authors
- Testa, Joseph R.
- Responsibility
- Joseph R. Testa, editor
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- 2017
- Physical Description
- 1 online resource (viii, 407 pages) : 65 illus., 43 illus. in color
- Series Title
- Current cancer research
- ISBN
- 9783319535609
- 9783319535586 (print ed.)
- ISSN
- 2199-2584
- Subjects (MeSH)
- Asbestos - adverse effects
- Mesothelioma - etiology
- Mesothelioma - genetics
- Mesothelioma - therapy
- Abstract
- This volume is comprised of a multidisciplinary assessment of the interplay between asbestos and cancer as well as new research about the biology and treatment of malignant mesothelioma. Chapters on the various types of asbestos and other mineral fibers, epidemiology, history and future of asbestos-related diseases are included. Other reviews present new information about the role of asbestos-related inflammation and genetic factors, including the role of inherited mutations of BAP1, in mesothelioma causation, as well as recent research about gene signatures, cell signaling, and epigenetic mechanisms in asbestos-related diseases. Other chapters provide updates of novel disease biomarkers and prevention, mechanistic lesson from genetically engineered mouse and 3-D models of mesothelioma tumorigenesis and therapeutic resistance. Also included are up-to-date reviews of surgical, molecularly targeted chemotherapeutic, and immunotherapeutic approaches for mesothelioma as well as an overview of legal issues.
- Contents
- 1. Malignant Mesothelioma: An Asbestos Legacy -- 2. Asbestos and Fibrous Erionite -- 3. Epidemiology of Mesothelioma -- 4. Malignant Pleural Mesothelioma: History, Controversy and Future of a Man-Made Epidemic -- 5. Communities at High Risk in the Third Wave of Mesothelioma -- 6. Mesothelioma Pathology -- 7. Asbestos-Induced Inflammation in Malignant Mesothelioma and Other Lung Diseases -- 8. Germline and Somatic Mutations in Human Mesothelioma and Lessons from Asbestos-Exposed Genetically Engineered Mouse Models -- 9. Gene Signature of Malignant Pleural Mesothelioma -- 10. Cell Signaling and Epigenetic Mechanisms in Mesothelioma -- 11. 3D Models of Mesothelioma in the Study of Mechanisms of Cell Survival -- 12. Biomarkers of Response to Asbestos Exposure -- 13. Surgery Approaches in Mesothelioma -- 14. Radiotherapy and Photodynamic Therapy for Malignant Pleural Mesothelioma -- 15. Standard Chemotherapy Options and Clinical Trials of Novel Agents for Mesothelioma -- 16. Immunotherapeutic Approaches to Mesothelioma -- 17. Challenges Facing Mesothelioma Patients and Their Families: Medical/Legal Intersections -- 18. The Patient's Experience of Malignant Mesothelioma.
- Format
- e-Book
- Location
- Online
Autophagy and cancer
https://libcat.nshealth.ca/en/permalink/provcat32578
Hong-Gang Wang, editor.
--New York, NY:
Springer
, c2013.
- Available Online
- View e-Book
- Location
- Online
This book covers the latest advances in the field of autophagy and cancer from the basics of the molecular machinery for autophagy induction and regulation up to current areas of interest, including modulation of autophagy and drug discovery for cancer prevention and treatment. The reader will be initially introduced to the historical context of autophagy, followed by a summary of the key players in autophagy, a discussion on the origin of autophagosomes, and an overview of signal transduction …
- Available Online
- View e-Book
- Other Authors
- Wang, Hong-Gang
- Responsibility
- Hong-Gang Wang, editor
- Place of Publication
- New York, NY
- Publisher
- Springer
- Date of Publication
- c2013
- Physical Description
- 1 online resource (xi, 261 p. : 33 ill., 29 ill. in color)
- Series Title
- Current cancer research
- ISBN
- 9781461465614
- Subjects (LCSH)
- Medicine
- Oncology
- Human physiology
- Cytology
- Abstract
- This book covers the latest advances in the field of autophagy and cancer from the basics of the molecular machinery for autophagy induction and regulation up to current areas of interest, including modulation of autophagy and drug discovery for cancer prevention and treatment. The reader will be initially introduced to the historical context of autophagy, followed by a summary of the key players in autophagy, a discussion on the origin of autophagosomes, and an overview of signal transduction regulation of autophagy. The next chapters deal with the complex relationship between autophagy and tumorigenesis through in-depth discussions of how autophagy influences cell survival, apoptosis, inflammation, immunity, tumor microenvironment, metabolic stress, DNA damage, and genomic instability. The remaining chapters discuss how autophagy affects cancer cell response to therapy and how to best modulate autophagy for therapeutic benefit - what to target and how to target. We hope that this monograph will be an invaluable reference source for professionals, students, postdoctoral fellows, and senior scientists working in the fields of autophagy and cancer.
- Contents
- Preface -- Historical Overview of Autophagy -- The Core Molecular Machinery of Autophagosome Formation -- The origin of autophagosomes: The beginning of an end -- Signal Transduction Regulation of Autophagy -- Role of Autophagy in Tumorigenesis -- Selective autophagy and cancer -- Oncogenes and tumor suppressor genes in autophagy -- Autophagy and Immunity -- Autophagy and the Tumor Microenvironment -- Autophagy and Cancer Therapy -- The Crosstalk between Apoptosis & Autophagy -- Autophagy and Cancer Drug Discovery -- Index.
- Format
- e-Book
- Location
- Online
Burkitt's lymphoma
https://libcat.nshealth.ca/en/permalink/provcat32384
Erle S. Robertson, editor.
--New York, NY:
Springer
, c2013.
- Available Online
- View e-Book
- Location
- Online
This volume aims to bring together efforts with a patient-oriented focus from physicians to diagnostics and clinical implications of the disease as mostly seen in the equatorial African setting. However, the chapters cover the breadth of studies on Burkitt's lymphoma with some clues for the potential future of Burkitt's lymphoma research that can have therapeutic benefits for patients. This text explore a range of topics associated with Burkitt's lymphoma, including molecular biology, diagnosi…
- Available Online
- View e-Book
- Other Authors
- Robertson, Erle S
- Responsibility
- Erle S. Robertson, editor
- Place of Publication
- New York, NY
- Publisher
- Springer
- Date of Publication
- c2013
- Physical Description
- 1 online resource (viii, 332 p. : 60 ill., 48 ill. in color)
- Series Title
- Current cancer research
- ISBN
- 9781461443131
- Subjects (MeSH)
- Africa South of the Sahara
- Burkitt Lymphoma
- Subjects (LCSH)
- Oncology
- Toxicology
- Abstract
- This volume aims to bring together efforts with a patient-oriented focus from physicians to diagnostics and clinical implications of the disease as mostly seen in the equatorial African setting. However, the chapters cover the breadth of studies on Burkitt's lymphoma with some clues for the potential future of Burkitt's lymphoma research that can have therapeutic benefits for patients. This text explore a range of topics associated with Burkitt's lymphoma, including molecular biology, diagnosis, its association with AIDS and Malaria, immune responses, therapeutic approaches and a unique view from the bedside. This volume is comprehensive and unique and represents the most up-to-date clinical and research activities on Burkitt's lymphoma.
- Contents
- Preface -- Introduction -- Diagnosis of Burkitt's Lymphoma -- Burkitt's Lymphoma : A View from the Bedside -- Clinical Implications of Burkitt's Lymphoma -- Definition of Burkitt's Lymphoma -- Classical and Endemic Burkitt's Lymphoma -- Sporadic Burkitt's Lymphoma -- AIDS-Associated Burkitt's Lymphoma -- Diffuse Large B-Cell Lymphoma and High Grade Diffuse Large B-Cell Lymphoma -- EBV Associated Burkitt's Lymphoma -- Molecular Biology of Burkitt's Lymphoma -- Burkitt's Lymphoma and the Immune Response -- The Many Roles of Malaria in the Etiology of Endemic Burkitt Lymphoma -- Therapeutic Approaches to Burkitt’s Lymphoma -- Animal Models of Burkitt’s Lymphoma -- Summary and Conclusion: Thinking About Latent BL -- Index.
- Format
- e-Book
- Location
- Online
Cancer Associated Viruses
https://libcat.nshealth.ca/en/permalink/provcat30906
Erle S. Robertson, editor.
--New York, NY:
Springer
, c2012.
- Available Online
- View e-Book
- Location
- Online
This volume constitutes a comprehensive review of the different aspects of tumor virology 100 years after the discovery of the Rous-sarcoma virus. Its aim is to bring a greater focus on the contributions of viral agents to the development of cancer, and to create an up to date compendium of the general molecular biology of these viruses, átheir gene products, and targeted functions. The content of the book comprises general chapters which tie into the many aspects of cancer-related viruses and …
- Available Online
- View e-Book
- Other Authors
- Robertson, Erle S
- Responsibility
- Erle S. Robertson, editor
- Place of Publication
- New York, NY
- Publisher
- Springer
- Date of Publication
- c2012
- Physical Description
- 1 online resource (xxiii, 866 p. : 125 ill., 68 ill. in color)
- Series Title
- Current cancer research
- ISBN
- 9781461400165
- Subjects (MeSH)
- Oncogenic Viruses
- Tumor Virus Infections
- Abstract
- This volume constitutes a comprehensive review of the different aspects of tumor virology 100 years after the discovery of the Rous-sarcoma virus. Its aim is to bring a greater focus on the contributions of viral agents to the development of cancer, and to create an up to date compendium of the general molecular biology of these viruses, átheir gene products, and targeted functions. The content of the book comprises general chapters which tie into the many aspects of cancer-related viruses and how they contribute to cell proliferation, the genes that are responsible for driving these cancers, and their mechanisms of transmission. The book also reviews the current knowledge on the molecular biology of large DNA viruses and describes the many different pathways through which they contribute to cell proliferation. Papilloma viruses and Adenoviruses, well known to be associated with invasive carcinomas, and hepatitis viruses, HTLV and retroviruses are also discussed. This volume is dedicated to Baruch Blumberg, an outstanding scientist and recipient of the Nobel Prize for the discovery of the hepatitis B virus, who was also the author of one of the chapters.
- Contents
- In Memoriam -- Preface -- 1. Peyton Rous: A centennial tribute to the founding father of cancer virology -- 2. Viruses and Cancer: A Historical Perspective – HBV and Prevention of a Cancer -- 3. Virus Mediated Cell Proliferation -- 4. Viral Encoded Genes and Cancer -- 5. Oncogenic Viruses and Cancer Transmission -- 6. DNA Viruses and Cancer: Taking a Broader Look -- 7. Herpesviruses and Cancer -- 8. Lymphocryptoviruses: EBV and its role in human cancer -- 9. Nonhuman Primate Gamma-herpesviruses and Their Role in Cancer -- 10. Rhadinoviruses: KSHV and associated malignancies -- 11. Retroperitoneal Fibromatosis Herpesvirus and Kaposi’s Sarcoma-Like Tumors in Macaques -- 12. Murine Gammaherpesvirus-Associated Tumorigenesis -- 13. Marek’s Disease Virus-Induced T-Cell Lymphomas -- 14. Polyoma Viruses and Cancer -- 15. Polyomavirus SV40: Model Infectious Agent of Cancer -- 16. BK Polyomavirus and Transformation -- 17. Polyomavirus JC and Human Cancer: Possible Role of Stem Cells in Pathogenesis -- 18. Merkel Cell Polyomavirus -- 19. Human Papillomaviruses and Cancer -- 20. Tumorigenesis by Adenovirus Type 12 E1A -- 21. Overview of Hepatitis Viruses and Cancer -- 22. Hepadnaviruses and Hepatocellular Carcinoma -- 23. Hepatitis C Virus and Hepatocellular Carcinoma -- 24. Human and Animal Retroviruses: HIV-1 Infection Is a Risk Factor for Malignancy -- 25. HTLV-1 and Oncogenesis -- 26. Human T-Cell Leukemia Virus Type 2 (HTLV-2) Biology and Pathogenesis -- 27. Mechanisms of Oncogenesis by Avian and Murine Retroviruses -- 28. Rous Sarcoma Virus: Contributions of a Chicken Virus to Tumor Biology, Human Cancer Therapeutics, and Retrovirology -- 29. Mouse Mammary Tumor Virus and Cancer -- 30. Jaagsiekte Sheep Retrovirus and Lung Cancer -- 31. Small RNAs and Their Role in Herpesvirus-Mediated Cancers -- 32. Viral Malignancies in HIV-Associated Immune Deficiency -- Index.
- Format
- e-Book
- Location
- Online
Caveolins in Cancer Pathogenesis, Prevention and Therapy
https://libcat.nshealth.ca/en/permalink/provcat30929
Isabelle Mercier, Jean-François Jasmin, Michael P. Lisanti, editors.
--New York, NY:
Springer
, c2012.
- Available Online
- View e-Book
- Location
- Online
For more than a decade, caveolin proteins have attracted a lot of attention in the field of cancer research. Additional roles besides maintaining the structural integrity of caveolae (meaning "little caves" in latin) have been attributed to these complex proteins. In fact, they have emerged as important regulators of cell signaling, proliferation, invasion and angiogenesis. The current book focuses on caveolin-1, the best-studied and well- characterized of all three caveolin family members (cav…
- Available Online
- View e-Book
- Other Authors
- Mercier, Isabelle
- Jasmin, Jean-François
- Lisanti, Michael P
- Responsibility
- Isabelle Mercier, Jean-François Jasmin, Michael P. Lisanti, editors
- Place of Publication
- New York, NY
- Publisher
- Springer
- Date of Publication
- c2012
- Physical Description
- 1 online resource (xi, 123 p. : 12 ill., 11 ill. in color)
- Series Title
- Current cancer research
- ISBN
- 9781461410010
- Subjects (MeSH)
- Caveolae - pathology
- Caveolin 1 - metabolism
- Caveolin 1 - physiology
- Neoplasms - metabolism
- Signal transduction
- Tumor Markers, Biological - metabolism
- Subjects (LCSH)
- Oncology
- Biochemistry
- Abstract
- For more than a decade, caveolin proteins have attracted a lot of attention in the field of cancer research. Additional roles besides maintaining the structural integrity of caveolae (meaning "little caves" in latin) have been attributed to these complex proteins. In fact, they have emerged as important regulators of cell signaling, proliferation, invasion and angiogenesis. The current book focuses on caveolin-1, the best-studied and well- characterized of all three caveolin family members (caveolin-1, -2 and -3). As such, the current chapters illustrate the roles of caveolin-1 in breast, prostate, skin, colon, brain and pancreatic cancers, and highlight its specific contribution to tumor growth through epithelial and stromal interactions, as well as its involvement in angiogenesis. This book summarizes the existing literature and provides interesting new perspectives on future advancement and therapeutic possibilities involving caveolins in cancer. This work brings together highly respected and experienced scientists in the field of caveolins who wrote informative chapters on the role of caveolin-1 in cancer in a format that conveys its role as both a tumor suppressor and tumor promoter. We invite you to read, enjoy and be part of these new promising discoveries that are rapidly advancing the field of cancer research.
- Contents
- Preface -- Local and Distant Effects of Caveolin-1 on Prostate Cancer Progression -- Caveolin-1 in Colon Cancer: the Flexible Connection to Wnt Signaling -- Caveolin-1 and Pancreatic Ductal Adenocarcinoma -- Caveolin-1 in Brain Tumors -- The Role of Caveolin-1 in Skin Cancer -- Caveolins and Tumor Angiogenesis -- Caveolin-1 and Breast Cancer -- Caveolin-1 and Cancer-Associated Stromal Fibroblasts -- Index.
- Format
- e-Book
- Location
- Online
Cell Cycle Deregulation in Cancer
https://libcat.nshealth.ca/en/permalink/provcat29848
edited by Greg H. Enders.
--New York, NY:
Springer Science+Business Media
, c2010.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Author
- Enders, Greg H
- Responsibility
- edited by Greg H. Enders
- Place of Publication
- New York, NY
- Publisher
- Springer Science+Business Media
- Date of Publication
- c2010
- Series Title
- Current cancer research
- ISBN
- 9781441917706
- Subjects (MeSH)
- Cell Cycle - physiology
- Cell Proliferation
- Neoplasms - metabolism
- Format
- e-Book
- Location
- Online
Chemical Carcinogenesis
https://libcat.nshealth.ca/en/permalink/provcat29650
edited by Trevor M. Penning.
--Totowa, NJ:
Springer Science+Business Media
, c2011.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Author
- Penning, Trevor M
- Responsibility
- edited by Trevor M. Penning
- Place of Publication
- Totowa, NJ
- Publisher
- Springer Science+Business Media
- Date of Publication
- c2011
- Series Title
- Current cancer research
- ISBN
- 9781617379956
- Subjects (MeSH)
- Carcinogens - toxicity
- DNA Damage
- Subjects (LCSH)
- Oncology
- Toxicology
- Format
- e-Book
- Location
- Online
Circulating Tumor Cells
https://libcat.nshealth.ca/en/permalink/provcat39716
Richard J. Cote, Ram H. Datar, editors.
--New York, NY:
Springer
, c2016.
- Available Online
- View e-Book
- Location
- Online
This volume provides the latest research on circulating tumor cells aimed for cancer researchers, scientists, and molecular oncologists. It presents the basic concepts behind circulating tumor cells (CTCs), metastatic biology, and potential applications as to how CTCs can be used in diagnostic biomarkers. CTCs are cells that have detached from the primary tumor and circulate in the bloodstream. Such cells may become "seeds" for the growth of additional tumors. The field of analysis surrounding …
- Available Online
- View e-Book
- Other Authors
- Cote, Richard J.
- Datar, Ram
- Responsibility
- Richard J. Cote, Ram H. Datar, editors
- Place of Publication
- New York, NY
- Publisher
- Springer
- Date of Publication
- c2016
- Physical Description
- 1 online resource (xxiv, 333 pages) : 31 illus., 2 illus. in color
- Series Title
- Current cancer research
- ISBN
- 9781493933631
- 9781493933617 (print ed.)
- ISSN
- 2199-2584
- 2199-2592 (e)
- Subjects (MeSH)
- Neoplasm Metastasis
- Neoplastic Cells, Circulating
- Abstract
- This volume provides the latest research on circulating tumor cells aimed for cancer researchers, scientists, and molecular oncologists. It presents the basic concepts behind circulating tumor cells (CTCs), metastatic biology, and potential applications as to how CTCs can be used in diagnostic biomarkers. CTCs are cells that have detached from the primary tumor and circulate in the bloodstream. Such cells may become "seeds" for the growth of additional tumors. The field of analysis surrounding cancer metastasis has been steadily growing, and CTCs provide effective biomarkers that can be examined in peripheral blood through a minimally invasive "liquid biopsy" procedure. CTCs offer several exciting applications, not only as markers of disease progression but also as biomarkers of monitoring response to therapy and companion diagnostics for novel anticancer drug development.There has been rapid progress in the field, fueled by research in basic science, biomedical engineering, and clinical applications. This book presents the latest developments from world-wide leaders, and will be useful for anyone interested in this important and expanding field.
- Contents
- Part I. Technologies for CTC Identification -- 1. Significance of Studying Circulating Tumor Cells -- 2. Affinity-Based Enrichment of Circulating Tumor Cells -- 3. Size-Based and Non-Affinity Based Microfluidic Devices for Circulating Tumor Cell Enrichment and Characterization -- 4. Molecular Assays for the Detection and Molecular Characterization of CTCs -- 5. Cancer Stem Cells and Circulating Tumor Cells Molecular Markers, Isolation Techniques and Clinical Implications -- Part II. Fundamental Studies of CTC -- 6. Circulating Tumor Cells and Tumor Dormancy -- 7. Prevention of Conversion of Tumor Dormancy into Proliferative Metastases -- 8. Genesis of Circulating Tumor Cells through Epithelial-Mesenchymal Transition as a Mechanism for Distant Dissemination -- Part III. CTC Analysis -- 9. CTC Analysis: FISH, ISH, Array-CGH and Other Molecular Assays -- 10. Genome-Wide Gene Copy Number Analysis of Circulating Tumor Cells -- 11. Perspectives on the Functional Characterization and In Vitro Maintenance of Circulating Tumor Cells -- 12. Prognostic Implications of CTC in Breast Cancer -- Part IV. Potential Clinical Applications of CTC -- 13. CTC in Advanced Breast Cancer Prognosis, Monitoring and Clinical Utility -- 14. Evolution of Metastatic Disease: The Need for Monitoring and Emerging Therapeutic Opportunities -- 15. CTC for Biomarker and Companion Diagnostic Development -- 16. Perspectives on Clinical Applications of CTCs.
- Format
- e-Book
- Location
- Online
D-type Cyclins and Cancer
https://libcat.nshealth.ca/en/permalink/provcat43257
Philip W. Hinds, Nelson E. Brown, editors.
--Cham:
Springer
, c2018.
- Available Online
- View e-Book
- Location
- Online
This volume provides an integrated account of our current understanding of the functions of D-type cyclins during development and tumorigenesis, with special emphasis on the kinase-independent functions of these proteins. The volume will provide a thorough review of the latest discoveries on the new functions and interacting partners of mammalian cyclin Ds crucial to explain their oncogenic and differentiation properties in different cellular contexts. The volume begins with a historical perspe…
- Available Online
- View e-Book
- Other Authors
- Hinds, Philip W.
- Brown, Nelson E.
- Responsibility
- Philip W. Hinds, Nelson E. Brown, editors
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2018
- Physical Description
- 1 online resource (ix, 152 p.) : 29 illus., 25 illus. in color
- Series Title
- Current cancer research
- ISBN
- 9783319644516
- 9783319644493 (print ed.)
- 9783319644509 (print ed.)
- 9783319877976 (print ed.)
- ISSN
- 2199-2584
- Subjects (MeSH)
- Carcinogenesis - genetics
- Cell Cycle - physiology
- Cyclin D - adverse effects
- Neoplasms - etiology
- Specialty
- Biochemistry
- Medical Oncology
- Abstract
- This volume provides an integrated account of our current understanding of the functions of D-type cyclins during development and tumorigenesis, with special emphasis on the kinase-independent functions of these proteins. The volume will provide a thorough review of the latest discoveries on the new functions and interacting partners of mammalian cyclin Ds crucial to explain their oncogenic and differentiation properties in different cellular contexts. The volume begins with a historical perspective of how D-type cyclins were first discovered and eventually cloned from cancer tissues, followed by an account on the canonical functions of cyclin Ds during the G1-S transition of the cell cycle. Several chapters will be devoted to review the functions of D-type cyclins as transcriptional regulators and the mechanisms through which these novel functions could impact the tumorigenic process. Also discussed is emerging evidence that points to a role of D-type cyclins, particularly cyclin D1, as a cytoplasmic regulator of various cellular functions. This property, in human cells at least, is traceable to certain splice isoforms with novel oncogenic implications. Finally, a chapter is devoted to recent efforts to revise the canonical view of the "retinoblastoma pathway" to incorporate new evidence that suggests that cyclin D1's role in G1 is to singly-phosphorylate the retinoblastoma protein (pRb) for discriminationáof target protein interactions. This work represents a significant departure from the view of cyclin D1 as a negative regulator of pRb and may have critical implications for understanding the function of antineoplastic agents that target the cyclin D1-associated kinases.
- Contents
- The D-type Cyclins: A Historical Perspective -- Mammalian Development and Cancer—A Brief History of Mice Lacking D-type Cyclins or Cdk4/6 -- D-type Cyclins and Gene Transcription -- Splice Variants and Phosphorylated Isoforms of Cyclin D1 in Tumorigenesis -- Cyclin D1, Metabolism, and the Autophagy-Senescence Balance -- Shifting a Paradigm: Cyclin D Activates pRb by Mono-Phosphorylation.
- Format
- e-Book
- Location
- Online
Early Phase Cancer Immunotherapy
https://libcat.nshealth.ca/en/permalink/provcat42936
Sandip Pravin Patel, Razelle Kurzrock, editors.
--Cham:
Springer
, c2018.
- Available Online
- View e-Book
- Location
- Online
This volume, a state-of-the-art review of early phase clinical trials for cancer immunotherapy, discusses biomarker selection, combinatorial strategies and their safety or toxicity, determination of Phase 2 dosing, endpoints in the setting of radiographic pseudoprogression, histology selection, and novel immunotherapeutics as they relate to early phase cancer immunotherapy.
- Available Online
- View e-Book
- Other Authors
- Patel, Sandip Pravin
- Kurzrock, Razelle
- Responsibility
- Sandip Pravin Patel, Razelle Kurzrock, editors
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2018
- Physical Description
- 1 online resource (xi, 331 p.) : 24 illus., 15 illus. in color
- Series Title
- Current cancer research
- ISBN
- 9783319637570
- 9783319637563 (print ed.)
- 9783319637587 (print ed.)
- 9783319876283 (print ed.)
- ISSN
- 2199-2584
- Subjects (MeSH)
- Clinical Trials, Phase I as Topic
- Clinical Trials, Phase II as Topic
- Immunotherapy - methods
- Neoplasms - therapy
- Specialty
- Medical Oncology
- Regenerative Medicine
- Abstract
- This volume, a state-of-the-art review of early phase clinical trials for cancer immunotherapy, discusses biomarker selection, combinatorial strategies and their safety or toxicity, determination of Phase 2 dosing, endpoints in the setting of radiographic pseudoprogression, histology selection, and novel immunotherapeutics as they relate to early phase cancer immunotherapy.
- Contents
- 1. Primer on Cancer Immunotherapy and the Targeting of Native Proteins -- 2. Pharmacokinetics and Pharmacodynamics of Immunotherapy -- 3. Immunotherapeutic Biomarkers and Selection Strategies -- 4. Radiographic Evaluation of Immunotherapy -- 5. Cellular Therapy -- 6. Combinatorial Checkpoint Blockade Immunotherapy and Radiation -- 7. Early Phase Cancer Immunotherapy -- 8. Immune Checkpoint Combinations with Inflammatory Pathway Modulators -- 9. Combinations of Genomically and Immune-Targeted Therapies in Early-Phase Clinical Trials -- 10. Thoracic Immunotherapy.
- Format
- e-Book
- Location
- Online
Gene-Based Therapies for Cancer
https://libcat.nshealth.ca/en/permalink/provcat29325
edited by Jack A. Roth.
--New York, NY:
Springer Science+Business Media
, c2010.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Author
- Roth, Jack A
- Responsibility
- edited by Jack A. Roth
- Place of Publication
- New York, NY
- Publisher
- Springer Science+Business Media
- Date of Publication
- c2010
- Series Title
- Current cancer research
- ISBN
- 9781441961020
- Subjects (MeSH)
- Genetic therapy - methods
- Neoplasms - therapy
- Subjects (LCSH)
- Gene therapy
- Oncology
- Format
- e-Book
- Location
- Online
Anne C. Chiang, Roy S. Herbst.
Humana
, 2021.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Responsibility
- Anne C. Chiang, Roy S. Herbst
- Publisher
- Humana
- Date of Publication
- 2021
- Physical Description
- 1 online resource (vi, 264 pages) : illustrations
- Series Title
- Current cancer research
- ISBN
- 9783030740283
- Specialty
- Medical Oncology
- Research
- Molecular Medicine
- Format
- e-Book
- Location
- Online
Microbiome and Cancer
https://libcat.nshealth.ca/en/permalink/provcat44161
Erle S. Robertson, editor.
--Cham:
Humana Press
, 2019.
- Available Online
- View e-Book
- Location
- Online
This book ventures into a new and exciting area of discovery that directly ties our current knowledge of cancer to the discovery of microorganisms associated with different types of cancers. Recent studies demonstrate that microorganisms are directly linked to the establishment of cancers and that they can also contribute to the initiation, as well as persistence of, the cancers. Microbiome and Cancer covers the current knowledge of microbiome and its association with human cancers. It provides…
- Available Online
- View e-Book
- Other Authors
- Robertson, Erle S.
- Responsibility
- Erle S. Robertson, editor
- Place of Publication
- Cham
- Publisher
- Humana Press
- Date of Publication
- 2019
- Physical Description
- 1 online resource (xiv, 401 p.) : 32 illus., 24 illus. in color
- Series
- Current Cancer Research
- Series Title
- Current cancer research
- ISBN
- 9783030041557
- 9783030041540 (Print ed.)
- 9783030041564 (Print ed.)
- ISSN
- 2199-2584
- Subjects (MeSH)
- Microbiota
- Neoplasms - etiology
- Neoplasms - microbiology
- Specialty
- Medical Oncology
- Microbiology
- Abstract
- This book ventures into a new and exciting area of discovery that directly ties our current knowledge of cancer to the discovery of microorganisms associated with different types of cancers. Recent studies demonstrate that microorganisms are directly linked to the establishment of cancers and that they can also contribute to the initiation, as well as persistence of, the cancers. Microbiome and Cancer covers the current knowledge of microbiome and its association with human cancers. It provides important reading for novices, senior undergraduates in cancer and microbiology, graduate students, junior investigators, residents, fellows and established investigators in the fields of cancer and microbiology. We cover areas related to known, broad concepts in microbiology and how they can relate to the ongoing discoveries of the micro-environment and the changes in the metabolic and physiologic states in that micro-environment, which are important for the ongoing nurturing and survival of the poly-microbial content that dictates activities in that micro-environment. We cover the interactions of microorganisms associated with gastric carcinomas, which are important for driving this particular cancer. Additional areas include oral cancers, skin cancers, ovarian cancers, breast cancers, nasopharyngeal cancers, lung cancers, mesotheliomas, Hodgkin’s and non-Hodgkin’s lymphomas, glioblastoma multiforme, hepatocellular carcinomas, as well as the inflammatory response related to the infectious agents in cancers. This book covers the metabolic changes that occur because of infection and their support for development of cancers, chronic infection and development of therapeutic strategies for detection and control of the infection. The field of microbiome research has exploded over the last five years, and we are now understanding more and more about the context in which microorganisms can contribute to the onset of cancers in humans. The field of microbiome research has demonstrated that the human body has specific biomes for tissues and that changes in these biomes at the specific organ sites can result in disease. These changes can result in dramatic differences in metabolic shifts that, together with genetic mutations, will produce the perfect niche for establishment of the particular infection programmes in that organ site. We are just beginning to understand what those changes are and how they influence the disease state. Overall, we hope to bring together the varying degrees of fluctuations in the microbiome at the major organ sites and how these changes affect the normal cellular processes because of dysregulation, leading to proliferation of the associated tissues.
- Contents
- 1. Microbiome and human malignancies -- 2. Infection based gastric cancers -- 3. Role of infectious agents on development of esophageal carcinomas -- 4. Viruses and glioblastoma: affliction or opportunity -- 5. The microbiome and its contribution to skin cancer -- 6. The role of the human virome in hematologic malignancies -- 7. Association of microbes with breast cancer -- 8. The microbiome associated with lung cancer -- 9. Mesothelioma and simian virus 40 infection -- 10. Infections related to development of head and neck cancers -- 11. Microbiota, infectious organisms and ovarian cancer -- 12. Hepatocellular cancer induced by infection -- 13. Manipulation of the host immune response by small DNA tumor viruses -- 14. Innate immune pattern recognition and the development of intestinal cancer -- 15. Microbial metabolites in cancer promotion or prevention -- 16. Rapid synthetic DNA vaccine development for emerging infectious disease outbreaks -- 17. Future perspectives: Microbiome, cancer and therapeutic promise.
- Format
- e-Book
- Location
- Online
Molecular determinants of head and neck cancer
https://libcat.nshealth.ca/en/permalink/provcat34014
Barbara Burtness, Erica Golemis, editors.
--New York:
Springer
, c2014.
- Available Online
- View e-Book
- Location
- Online
Head and neck cancers, involving sites from the nasopharynx to the subglottic larynx, are frequently devastating cancers that afflict patients around the world. These cancers are frequently locally advanced prior to detection, and require multimodality therapy that is associated with high morbidity. As this book addresses this difficult disease, it accomplishes three main goals. First, it introduces the etiology and subclasses of squamous cell carcinomas of the head and neck (SCCHNs), and how t…
- Available Online
- View e-Book
- Other Authors
- Burtness, Barbara
- Golemis, Erica
- Responsibility
- Barbara Burtness, Erica Golemis, editors
- Place of Publication
- New York
- Publisher
- Springer
- Date of Publication
- c2014
- Physical Description
- 1 online resource (ix, 362 pages)
- Series Title
- Current cancer research
- ISBN
- 9781461488156 (electronic bk.)
- 9781461488149
- Subjects (MeSH)
- Head and Neck Neoplasms - etiology
- Head and Neck Neoplasms - genetics
- Head and Neck Neoplasms - therapy
- Subjects (LCSH)
- Head - Cancer - Diagnosis
- Neck - Cancer - Diagnosis
- Head - Cancer - Treatment
- Neck - Cancer - Treatment
- Médecine
- Abstract
- Head and neck cancers, involving sites from the nasopharynx to the subglottic larynx, are frequently devastating cancers that afflict patients around the world. These cancers are frequently locally advanced prior to detection, and require multimodality therapy that is associated with high morbidity. As this book addresses this difficult disease, it accomplishes three main goals. First, it introduces the etiology and subclasses of squamous cell carcinomas of the head and neck (SCCHNs), and how these factors affect prognosis. Although habitual exposures to tobacco, alcohol, and other agents have historically been the main causes of SCCHN, a rising proportion of oropharynx cancers arise from transforming human papillomavirus (HPV) infection. These two broad classes of SCCHN have significant differences in disease profile and response to treatment, as we discuss. Second, it summarizes the current state of understanding of the genetic, epigenetic and protein expression changes associated with the various classes of SCCHN. In the past decade, disease pathogenesis of SCCHN has been appreciated to involve deregulation of multiple tumor pathways, including the receptor tyrosine kinases (RTKs) EGFR, ERBB2, ERBB3, c-MET, and IGF1R; transforming growth factor c (TGFc); Notch; cytoplasmic signaling proteins including PTEN, PI3K, JAK/STAT, and Wnt-responsive c-catenin; mutation control systems, including p53 and the DNA damage repair (DDR) machinery; and hypoxic response. The specific understanding of the action of these proteins in SCCHN is presented here. Finally, this book defines potential therapeutic targets for improved management of the disease in the future, discussing prospects for improved prediction of prognosis.
- Contents
- 1. Overview: The Pathobiology of Head and Neck Cancer -- 2. Molecular Features and Treatment Modalities of “Classic” Versus Human Papilloma Virus-Associated Head and Neck Cancer -- 3. Epidemiology of HPV in Head and Neck Cancer: Variant Strains, Discrete Protein Function -- 4. EGFR Inhibitors as Therapeutic Agents in Head and Neck Cancer -- 5. The Role of HGF/c-MET in Head and Neck Squamous Cell Carcinoma -- 6. Insulin-like Growth Factor-1 Receptors in Head and Neck Cancer -- 7. The PI3K Signaling Pathway in Head and Neck Squamous Cell Carcinoma -- 8. Jak/STAT Signaling in HNC -- 9. TGFß Regulates EMT in Head and Neck Cancer -- 10. The Wnt/ß-catenin Signaling Circuitry in Head and Neck Cancer -- 11. Human Papillomavirus (HPV)-Positive Head and Neck Cancer and the Wnt Signaling Pathway -- 12. p53 in Head and Neck Cancer -- 13. DNA Damage Proteins and Response to Therapy in Head and Neck Cancer -- 14. Hypoxia and Radioresistance in Head and Neck Cancer -- 15. Sequencing HNC: Emergence of Notch Signaling -- 16. Gene Expression in HNC -- 17. Projections: Novel Therapies for HPV-Negative Cancers of the Head and Neck.
- Format
- e-Book
- Location
- Online
Molecular Determinants of Head and Neck Cancer
https://libcat.nshealth.ca/en/permalink/provcat42783
Barbara Burtness, Erica A. Golemis, editors.
(Second edition)
--Cham:
Humana Press
, c2018.
- Available Online
- View e-Book
- Location
- Online
Squamous cell cancers of the head and neck (SCCHN), also known as head and neck cancers (HNC) encompass malignancies of the oral cavity, larynx, nasopharynx and pharynx, and are diagnosed in over 500,000 patients worldwide each year, accounting for 5% of all malignancies. It is estimated that approximately 50,000 patients develop head and neck cancer annually in the United States, of whom approximately 50% succumb to this cancer. For most cases of SCCHN, treatment is multimodal, often combining…
- Available Online
- View e-Book
- Other Authors
- Burtness, Barbara
- Golemis, Erica A.
- Responsibility
- Barbara Burtness, Erica A. Golemis, editors
- Edition
- Second edition
- Place of Publication
- Cham
- Publisher
- Humana Press
- Date of Publication
- c2018
- Physical Description
- 1 online resource (vi, 629 p.) : 68 illus., 62 illus. in color
- Series Title
- Current cancer research
- ISBN
- 9783319787626
- 9783319787619 (print ed.)
- 9783319787633 (print ed.)
- ISSN
- 2199-2584
- Subjects (MeSH)
- Head and Neck Neoplasms - etiology
- Head and Neck Neoplasms - genetics
- Head and Neck Neoplasms - therapy
- Specialty
- Medical Oncology
- Molecular Medicine
- Abstract
- Squamous cell cancers of the head and neck (SCCHN), also known as head and neck cancers (HNC) encompass malignancies of the oral cavity, larynx, nasopharynx and pharynx, and are diagnosed in over 500,000 patients worldwide each year, accounting for 5% of all malignancies. It is estimated that approximately 50,000 patients develop head and neck cancer annually in the United States, of whom approximately 50% succumb to this cancer. For most cases of SCCHN, treatment is multimodal, often combining surgery or irradiation with chemotherapy; even successfully treated patients frequently experience durable and severe side effects. Improving cure rates and reducing chronic morbidity are urgent clinical needs for head and neck cancer. However, in contrast to cancer types such as breast or prostate that have been much studied and have well-defined biology, until recently, relatively few researchers investigated the molecular basis of HNC, making it difficult to design targeted treatments with better efficacy and less debilitating side effects. This volume will provide an overview of the factors contributing to disease pathogenesis, including the recognition of discrete molecular subtypes with distinct etiology, prognosis, and treatment response. This volume will familiarize the reader with the critical signaling pathways and oncogenic drivers for HNC. It will outline the differences between HPV-positive and HPV-negative disease, and how these differences affect treatment choice and outcome. The book will emphasize developments in the past five years, including the growing understanding of the genomic and epigenomic features of the disease based on analysis of next generation sequencing (NGS) data, and timely topics such as the analysis of HNC stem cell populations, non-coding mRNAs, and inflammatory response. It will address exciting new therapeutic approaches such as the use of immunotherapies to treat HNC patients. Overall, the book will provide the reader with current understanding of the biology and treatment of the disease, and describe timely questions that will guide future research aimed at controlling and curing this disease.
- Contents
- 1. Overview: The Pathobiology of Head and Neck Cancer -- 2. Targeting the ErbB Family in Head and Neck Cancer -- 3. c-MET in Head and Neck Squamous Cell Carcinoma -- 4. Transforming Growth Factor Beta (TGF-ß) Signaling in Head and Neck Squamous Cell Carcinoma (HNSCC) -- 5. The PI3K Signaling Pathway in Head and Neck Squamous Cell Carcinoma -- 6. Jak/STAT Signaling in Head and Neck Cancer -- 7. Molecular Regulation of Cell Cycle and Cell Cycle-Targeted Therapies in Head and Neck Squamous Cell Carcinoma (HNSCC -- 8. Role of the NOTCH Signaling Pathway in Head and Neck Cancer -- 9. P53 in Head and Neck Squamous Cell Carcinoma -- 10. APOBEC as an Endogenous Mutagen in Cancers of the Head and Neck -- 11. The Genome-Wide Molecular Landscape of HPV-Driven and HPV-Negative Head and Neck Squamous Cell Carcinoma -- 12. Epigenetic Changes and Epigenetic Targets in Head and Neck Cancer -- 13. Inflammation and Head and Neck Squamous Cell Carcinoma -- 14. Immunotherapy in Head and Neck Squamous Cell Carcinoma (HNSCC -- 15. The Clinical Impact of Hypoxia in Head and Neck Squamous Cell Carcinoma -- 16. Angiogenesis and Anti-angiogenic Therapy in Head and Neck Cancer -- 17. FAK as a Target for Therapy in Head and Neck Cancer -- 18. Diversity of Wnt/ß-Catenin Signaling in Head and Neck Cancer: Cancer Stem Cells, Epithelial-to-Mesenchymal Transition, and Tumor Microenvironment -- 19. Hyaluronan-Mediated CD44 Signaling Activates Cancer Stem Cells in Head and Neck Cancer -- 20. Biology and Epidemiology of Human Papillomavirus-Related Head and Neck Cancer -- 21. Treatment Paradigms in HPV-Associated SCCHN.
- Format
- e-Book
- Location
- Online
Protein Kinase C in Cancer Signaling and Therapy
https://libcat.nshealth.ca/en/permalink/provcat29049
edited by Marcelo G. Kazanietz.
--Totowa, NJ:
Springer Science+Business Media
, c2010.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Author
- Kazanietz, Marcelo G
- Responsibility
- edited by Marcelo G. Kazanietz
- Place of Publication
- Totowa, NJ
- Publisher
- Springer Science+Business Media
- Date of Publication
- c2010
- Series Title
- Current cancer research
- ISBN
- 9781607615439
- Subjects (LCSH)
- Oncology
- Biochemistry
- Format
- e-Book
- Location
- Online
Targeted Therapy of Acute Myeloid Leukemia
https://libcat.nshealth.ca/en/permalink/provcat38946
Michael Andreeff, editor.
--New York, NY:
Springer
, c2015.
- Available Online
- View e-Book
- Location
- Online
This book provides an unprecedented overview of targeted therapies for acute myeloid leukemias. The volume provides comprehensive coverage of the diverse therapeutic strategies that have been developed during the last decade and are now being evaluated in early clinical trials. Authoritative chapters are written by leading research scientists and clinicians, who explain basic concepts and the clinical translation of topics that include the underlying genetic and proteomic abnormalities of AML. …
- Available Online
- View e-Book
- Other Authors
- Andreeff, Michael
- Responsibility
- Michael Andreeff, editor
- Place of Publication
- New York, NY
- Publisher
- Springer
- Date of Publication
- c2015
- Physical Description
- 1 online resource (xix, 826 p. : 62 illus., 46 illus. in color)
- Series Title
- Current cancer research
- ISBN
- 9781493913930
- 9781493913923 (print ed.)
- Abstract
- This book provides an unprecedented overview of targeted therapies for acute myeloid leukemias. The volume provides comprehensive coverage of the diverse therapeutic strategies that have been developed during the last decade and are now being evaluated in early clinical trials. Authoritative chapters are written by leading research scientists and clinicians, who explain basic concepts and the clinical translation of topics that include the underlying genetic and proteomic abnormalities of AML. The chapter topics include the development of novel nucleoside analogues, the roles of microRNAs, apoptosis regulators Bcl-2 and p53, and of critical cell signaling proteins such as PIM, FLT3, Raf/MEK, PI3K/AKT/mTOR and aurora kinases. In addition, chapters on epigenetic mechanisms, nuclear receptors, cell surface antigens, the hypoxic leukemia microenvironment, stem cells, and leukemia metabolism, provide insight into leukemia cell vulnerabilities. Cell therapies utilizing T-, NK- and mesenchymal stem cells and progress in hematopoietic transplantation strategies complete the overview of the multi-dimensional therapeutic landscape, where leukemia specialists develop treatment strategies, which are expected to bring forth critical breakthroughs in the field of leukemia.
- Contents
- [publisher supplied] Introduction/Perspective -- Genetics and Classification of Acute Myeloid Leukemia -- Proteomics of AML to guide Selection of Therapy -- Roles of Apoptosis Regulating Bcl-2-Family Genes in AML -- Bcl-2 family: Translational aspects -- IAP Family and Proteins as Therapeutic Targets for Acute Myeloid Leukemia -- TP53 Mutations in Acute Myeloid Leukemia -- Targeting p53 Tumor Suppressor for AML Therapy -- AML-Selective Apoptosis Induction by rationally designed Death Ligand Fusion Protein -- PIM Kinases in AML -- Development of Midostaurin as a Tyrosine Kinase Inhabitor -- FLT3 in AML -- FLT3-ITD. Clinical (Sorafenib/AC220) -- Nucleophosmin (NPM1) -- Raf/MEK Pathway -- The Role of Translational Medicine in Optimization of Therapies targeting the RAS-MAP Kinase Pathway -- Clinical Use of Farnesyltransferase Inhititors -- The P13K-AKT-mTOR signaling Network in AML -- Targeting the P13 Kinase-mTOR Signaling Pathway in AML -- Aurora kinases -- The Clinical Development of Aurora Kinase Inhibitors in Acute Myeloid Leukemia -- AML-Deacetylases -- Methylation in AML-Clinical Applications -- Topic: RARa/RXR Part: Basic -- Arsenic Trioxide in Untreated APL -- Targeting PML-RAR with Retinoids -- NR4A Orphan Receptors as Drug Targets -- Antibody-based Therapeutics Targeting CD33, CD45, and CD66 -- New Heterogeneity of the Leukemic Stem Cells -- Targeting Leukemia Stem Cells -- Regulation of Hematopoiesis by CXCL12/CXCR4 Signaling -- CXC4/CXCL12 as a Therapeutic Target -- VLA-4: A Cell's Consequential Encounter -- VLA-4 Function and Prognosis in Acute Myeloid Leukemia -- VLA4 in Acute Lymphoblastic Leukemia -- The Leukemic Bone Marrow Microenvironment: Targeting Hypoxia with Hypoxia Activated Pro-Drugs -- Topic: miRs as Therapeutic Targets -- Clinical Implications of MicroRNAs in AML -- Inhibition of Glycolysis as a Therapeutic Strategy in Acute Myeloid Leukemias -- Molecular and Biochemical Basis for the Reprogramming of Intermediary Metabolism in Leukemia Cells -- NK Cell Immunotherapy for AML -- Allogeneic and Autologous T cell Strategies to Enhance Targeting of Acute Myeloid Leukemia -- Indications for Hematopoietic Transplantation for AML -- Mesenchymal Stem/Stromal Cell Targeted Therapies for Solid Tumors and Hematological Malignancies.
- Format
- e-Book
- Location
- Online
Targeting Autophagy in Cancer Therapy
https://libcat.nshealth.ca/en/permalink/provcat40313
Jin-Ming Yang, editor.
--Cham:
Springer
, c2016.
- Available Online
- View e-Book
- Location
- Online
This volume will detail the current state and perspectives of autophagy-based cancer therapy. Covering a wide range of topics, it will include an overview of autophagy as a therapeutic target in cancer, autophagy modulators as cancer therapeutic agents, implications of micro-RNA-regulated autophagy in cancer therapy, modulation of autophagy through targeting PI3 kinase in cancer therapy, targeting autophagy in cancer stem cells, and roles of autophagy in cancer immunotherapy. In addition, the v…
- Available Online
- View e-Book
- Other Authors
- Yang, Jin-Ming
- Responsibility
- Jin-Ming Yang, editor
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2016
- Physical Description
- 1 online resource (vii, 141 p. : 12 illus., 10 illus. in color)
- Series Title
- Current cancer research
- ISBN
- 9783319427409
- 9783319427386 (print ed.)
- ISSN
- 2199-2584
- Subjects (MeSH)
- Antineoplastic Agents - therapeutic use
- Autophagy - drug effects
- Neoplasms - genetics
- Neoplasms - therapy
- Abstract
- This volume will detail the current state and perspectives of autophagy-based cancer therapy. Covering a wide range of topics, it will include an overview of autophagy as a therapeutic target in cancer, autophagy modulators as cancer therapeutic agents, implications of micro-RNA-regulated autophagy in cancer therapy, modulation of autophagy through targeting PI3 kinase in cancer therapy, targeting autophagy in cancer stem cells, and roles of autophagy in cancer immunotherapy. In addition, the volume will review applications of system biology and bioinformatics approaches to discovering cancer therapeutic targets in the autophagy regulatory network. The volume will be beneficial for a variety of basic and clinical scientists, including cancer biologists, autophagy researchers, pharmacologists, and clinical oncologists who wish to delve more deeply into this field of cancer research. This volume will be the first book to focus solely on autophagy as a target in cancer therapy. As well, it will comprehensively discuss the roles of autophagy in most currently available cancer treatments.
- Contents
- 1. Autophagy as a Therapeutic Target in Cancer -- 2. Autophagy in Cancer Cells vs. Cancer Tissues: Two Different Stories -- 3 .Small-Molecule Regulators of Autophagy as Potential Anti-cancer Therapy -- 4. Regulation of Autophagy by microRNAs: Implications in Cancer Therapy -- 5. Targeting PI3-Kinases in Modulating Autophagy and Anti-cancer Therapy -- 6. Adult and Cancer Stem Cells: Perspectives on Autophagic Fate Determinations and Molecular Intervention -- 7. Role of Autophagy in Tumor Progression and Regression.
- Format
- e-Book
- Location
- Online
