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Adipocytic, Vascular and Skeletal Muscle Tumors : A Practical Diagnostic Approach

https://libcat.nshealth.ca/en/permalink/provcat45373
Raf Sciot, Clara Gerosa, Gavino Faa, editors. --Cham: Humana Press , c2020.
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This book focuses on the subsets of soft tissue tumors that show adipocytic, vascular or skeletal muscle differentiation. It reviews the surgical pathologists’ approach to diagnosing soft tissue tumors guided by vital morphological and immunohistochemical data in the differential diagnosis of this family of tumors. Written by experts in the field, the text contains a concise yet comprehensive summary of the current status of the field that helps guide diagnosis and patient management, and stimu…
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Other Authors
Sciot, Raf
Gerosa, Clara
Faa, Gavino
Responsibility
Raf Sciot, Clara Gerosa, Gavino Faa, editors
Place of Publication
Cham
Publisher
Humana Press
Date of Publication
c2020
Physical Description
1 online resource (xi, 182 p.)
Series Title
Current clinical pathology
ISBN
9783030374600
9783030374594 (Print ed.)
9783030374617 (Print ed.)
9783030374624 (Print ed.)
ISSN
2197-781X
Subjects (MeSH)
Soft Tissue Neoplasms - diagnosis
Soft Tissue Neoplasms - pathology
Specialty
Diagnosis
Medical Oncology
Pathology
Abstract
This book focuses on the subsets of soft tissue tumors that show adipocytic, vascular or skeletal muscle differentiation. It reviews the surgical pathologists’ approach to diagnosing soft tissue tumors guided by vital morphological and immunohistochemical data in the differential diagnosis of this family of tumors. Written by experts in the field, the text contains a concise yet comprehensive summary of the current status of the field that helps guide diagnosis and patient management, and stimulates investigative efforts. The book is filled with high-quality drawings of the salient histologic features of these various tumors, alongside photomicrographs and tips and tricks that help the relatively untrained or inexperienced eye to recognize the various structures or cell types that comprise each of these lesions. This innovative approach seeks to make recognition of these tumors easier. Adipocytic, Vascular and Skeletal Muscle Tumors serves as a valuable resource for pathologists, oncologists, surgeons, and researchers dealing with and interested in these complex and challenging tumors.
Contents
1. Adipocytic Tumors -- 2. Vascular Tumors -- 3. Skeletal Muscle Tumors.
Format
e-Book
Location
Online
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Advanced Imaging Techniques in Clinical Pathology

https://libcat.nshealth.ca/en/permalink/provcat39722
Francesco M. Sacerdoti, Antonio Giordano, Carlo Cavaliere, editors. --New York, NY: Springer New York : Imprint: Humana Press , c2016.
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This text provides a comprehensive, state-of-the-art review of the application of image analysis focusing on the techniques which can be used in every biology and medical laboratory to automate procedures of cell analysis and to create statistics very useful for a comprehension of cell growth dynamics and the effects of drugs on them. This textbook will serve as a very useful resource for physicians and researchers dealing with, and interested in, cell analysis. It will provide a concise yet co…
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Other Authors
Sacerdoti, Francesco M
Giordano, Antonio
Cavaliere, Carlo
Responsibility
Francesco M. Sacerdoti, Antonio Giordano, Carlo Cavaliere, editors
Place of Publication
New York, NY
Publisher
Springer New York : Imprint: Humana Press
Date of Publication
c2016
Physical Description
1 online resource (ix, 165 p. : 53 illus., 37 illus. in color)
Series Title
Current clinical pathology
ISBN
9781493934690
9781493934676 (print ed.)
ISSN
2197-781X
Subjects (MeSH)
Clinical Laboratory Techniques
Diagnostic Imaging
Pathology, Clinical - methods
Abstract
This text provides a comprehensive, state-of-the-art review of the application of image analysis focusing on the techniques which can be used in every biology and medical laboratory to automate procedures of cell analysis and to create statistics very useful for a comprehension of cell growth dynamics and the effects of drugs on them. This textbook will serve as a very useful resource for physicians and researchers dealing with, and interested in, cell analysis. It will provide a concise yet comprehensive summary of the current status of the field that will help guide patient management and stimulate investigative efforts. All chapters are written by experts in their fields and include the most up-to-date scientific and clinical information. Advanced Imaging Techniques in Clinical Pathology will be of great value to clinical pathologists, biologists, biology researchers, and those working in the clinical and biological laboratory arena.
Contents
1 Introduction -- Part I. Basic Knowledge -- 2 Digital Image Processing -- 3 Statistical Analysis and Software -- Part II. Applications -- 4 Microscopy Techniques -- 5 Cytometry and Pathology -- 6 Advanced Imaging Techniques -- Part III. Diagnostic Imaging and Pathology -- 7 Diagnostic Imaging and Pathology -- 8 Preclinical Techniques in Animals -- 9 Preclinical Imaging: Experimental Example -- 10 Clinical Techniques in Humans -- 11 Clinical Imaging Experimental Example in Pathology -- 12 Ultrasound in the Evaluation of Cutaneous Diseases -- 13 Diagnostic Imaging Techniques: Lessons Learned -- Erratum to: Advanced Imaging Techniques in Clinical Pathology.
Format
e-Book
Location
Online
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Amyloid and Related Disorders : Surgical Pathology and Clinical Correlations

https://libcat.nshealth.ca/en/permalink/provcat39337
Maria M. Picken, Guillermo A. Herrera, Ahmet Dogan, editors. (Second edition) --Cham: Springer International Publishing : Imprint: Humana Press , c2015.
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The second edition of this text presents an overview of the most recent developments in this area including clinical presentation, etiology, pathogenesis, and differential diagnosis. The rationale for various therapies, including transplantation, is discussed and tissue diagnosis (its pitfalls and strategies for avoiding them) and laboratory support are included. The involvement of all major organ systems including renal/genitourinary, cardiac, gastrointestinal, pulmonary, peripheral nerve/cent…
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Other Authors
Picken, Maria M
Herrera, Guillermo A
Dogan, Ahmet
Responsibility
Maria M. Picken, Guillermo A. Herrera, Ahmet Dogan, editors
Edition
Second edition
Place of Publication
Cham
Publisher
Springer International Publishing : Imprint: Humana Press
Date of Publication
c2015
Physical Description
1 online resource (xix, 542 p. : 391 illus., 345 illus. in color)
Series Title
Current clinical pathology
ISBN
9783319192949
9783319192932 (print ed.)
ISSN
2197-781X
Subjects (MeSH)
Amyloid - adverse effects
Amyloidosis - diagnosis
Amyloidosis - pathology
Amyloidosis - therapy
Abstract
The second edition of this text presents an overview of the most recent developments in this area including clinical presentation, etiology, pathogenesis, and differential diagnosis. The rationale for various therapies, including transplantation, is discussed and tissue diagnosis (its pitfalls and strategies for avoiding them) and laboratory support are included. The involvement of all major organ systems including renal/genitourinary, cardiac, gastrointestinal, pulmonary, peripheral nerve/central nervous system, soft tissue, skin, lymph node/spleen and bone marrow pathology is also covered. Amyloid and Related Disorders, Second Edition will be invaluable to specialized and general pathologists as well as cytopathologists. Other medical professionals may also benefit from this concise update on the systemic amyloidoses.
Contents
[publisher supplied] Introduction/general -- Aspects of the history and nomenclature of amyloid and amyloidosis -- Amyloid diseases at the molecular level: general overview and focus on AL amyloidosis -- AA amyloidosis -- Non-Immunoglobulin and non-AA amyloidoses -- The hereditary amyloidoses -- Dialysis-associated amyloidosis -- Localized amyloidoses and amyloidoses associated with aging outside the central nervous system -- Central nervous system amyloid -- Non-amyloid protein deposits -- Differential diagnosis of amyloid in surgical pathology: organized deposits and other material in the differential diagnosis of amyloidosis -- Light /heavy chain deposition disease as a systemic disease -- Glomerulonephritis with non-organized monoclonal immunoglobulin deposits -- Pathologies of renal and systemic intracellular paraprotein storage: crystalopathies and beyond -- Diagnosis -- Diagnosis of amyloid using Congo red: polarized and fluorescence -- Thioflavin T stain for amyloid detection -- Fat tissue analysis in the management of patients with systemic amyloidosis -- Generic diagnosis of amyloid: recent developments and summary of current recommendations -- Amyloid typing on formalin-fixed paraffin sections by immunohistochemistry: experience from two large referral centers -- Options for amyloid typing in renal pathology: the advantages of frozen section immunofluorescence -- Amyloid typing by immuno-electron microscopy -- Classification of amyloidosis by mass spectrometry-based proteomics -- Summary and practical recommendation regarding amyloid typing using antibody-based and proteomic methods -- Ancillary studies of amyloidosis -- Laboratory support for diagnosis of amyloidosis -- Bone marrow biopsy and its utility in the diagnosis of AL amyloidosis and other plasma cell dyscrasias -- Molecular methods for the diagnosis of hereditary amyloidosis -- Radiologic support for diagnosis and monitoring of amyloidosis: established techniques and recent developments -- Organ involvement in amyloidoses -- Amyloidoses of the Kidney and Genitourinary tract -- Cardiac amyloidosis -- Amyloidosis of the Gastrointestinal tract and Liver -- Peripheral nerve amyloidosis -- Amyloidoses of the Pulmonary and upper respiratory tract -- Amyloidoses involving the skin -- Clinical issues and therapy -- Clinico-pathologic issues in patients with amyloidosis -- Solid organ transplantation in amyloidosis and issues pertaining to domino liver transplantation -- Emerging therapies for amyloidosis -- Clinical trials -- Modern therapies in AA amyloidosis -- Medico legal issues of amyloidosis -- Amyloidosis from the patient's perspective.
Format
e-Book
Location
Online
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Biotargets of Cancer in Current Clinical Practice

https://libcat.nshealth.ca/en/permalink/provcat31016
Mauro Bologna, editor. --New York, NY: Humana Press , c2012.
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Biotargets of Cancer in Current Clinical Practice presents an updated and reasoned review of the current status of knowledge concerning the major cancer types with a special focus on the current biomarkers, genes involved and the potential future targets of innovative therapies. The volume includes for each major cancer type, a comprehensive although concise discussion of epidemiology, affirmed and innovative biomarkers for diagnosis, and descriptions of the relevant genes for prognosis and (in…
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Other Authors
Bologna, Mauro
Responsibility
Mauro Bologna, editor
Place of Publication
New York, NY
Publisher
Humana Press
Date of Publication
c2012
Physical Description
1 online resource (xvi, 563 p. : 100 ill., 57 ill. in color)
Series Title
Current clinical pathology
ISBN
9781617796159
Subjects (MeSH)
Biological Markers
Molecular Targeted Therapy
Neoplasms - therapy
Subjects (LCSH)
Medical laboratories
Oncology
Pathology
Abstract
Biotargets of Cancer in Current Clinical Practice presents an updated and reasoned review of the current status of knowledge concerning the major cancer types with a special focus on the current biomarkers, genes involved and the potential future targets of innovative therapies. The volume includes for each major cancer type, a comprehensive although concise discussion of epidemiology, affirmed and innovative biomarkers for diagnosis, and descriptions of the relevant genes for prognosis and (individualized) therapy through biotarget-specific new molecular treatments, with the latest information on the validation status of each novel biomarker. Individual chapters are dedicated to the major cancer types, plus a special chapter on metastasis. The present debate on patentability of genetic information applied to diagnostics and therapeutics of cancer is also discussed.
Contents
Central Nervous System Tumors -- Head and Neck Tumors -- Thyroid Cancer -- Targeted Therapies for Non-Small Cell Lung Cancer -- Non-Hodgkin Lymphomas -- Leukemias -- Breast Cancer -- Esophago-Gastric Cancer -- Colorectal Cancer -- Hepatocellular Carcinoma -- Biomarkers for Prognosis and Molecularly Targeted Therapy in Renal Cell Carcinoma -- Bladder Cancer -- Biomarkers in Prostate cancer -- Ovarian Cancer -- Uterine Cancer: The Influence of Genetics and Environment on Cell Cycling Pathways in Cancer -- Biotargets in Sarcomas: The Past, Present and a Look into the Future -- Melanoma and other skin cancers -- Molecular pathology of cancer metastasis: suggestions for future therapy -- Current and future developments in cancer therapy research: miRNAs as new promising targets or tools.
Format
e-Book
Location
Online
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Breast Cancer and its Precursor Lesions : Making Sense and Making It Early

https://libcat.nshealth.ca/en/permalink/provcat30392
edited by Patricia A. Thomas. --Totowa, NJ: Springer Science+Business Media , c2011.
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Online
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Author
Thomas, Patricia A
Responsibility
edited by Patricia A. Thomas
Place of Publication
Totowa, NJ
Publisher
Springer Science+Business Media
Date of Publication
c2011
Series Title
Current clinical pathology
ISBN
9781603271547
Subjects (MeSH)
Breast Neoplasms - prevention & control
Subjects (LCSH)
Oncology
Pathology
Format
e-Book
Location
Online
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Cardiac tumor pathology

https://libcat.nshealth.ca/en/permalink/provcat32452
Cristina Basso, Marialuisa Valente, Gaetano Thiene, editors. --New York, NY: Humana Press , c2013.
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Cardiac tumors were once a nosographic entity of scarce clinical interest because of the rarity and of the intrinsic diagnostic and therapeutic impossibilities, and were considered a fatal morbid entity. It has now become a topical subject due to advances in clinical imaging (echo, magnetic resonance, computed tomography) as well as innovation in technologies of in-vivo diagnosis. Cardiac Tumor Pathology presents a spectacular example of these advances with clinico-pathologic correlations. Thi…
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Other Authors
Basso, Cristina
Valente, Marialuisa
Thiene, Gaetano
Responsibility
Cristina Basso, Marialuisa Valente, Gaetano Thiene, editors
Place of Publication
New York, NY
Publisher
Humana Press
Date of Publication
c2013
Physical Description
1 online resource (xiv, 197 p. : 139 ill., 105 ill. in color)
Series Title
Current clinical pathology
ISBN
9781627031431
Subjects (MeSH)
Heart Neoplasms - pathology
Subjects (LCSH)
Radiology, Medical
Cardiology
Oncology
Pathology
Abstract
Cardiac tumors were once a nosographic entity of scarce clinical interest because of the rarity and of the intrinsic diagnostic and therapeutic impossibilities, and were considered a fatal morbid entity. It has now become a topical subject due to advances in clinical imaging (echo, magnetic resonance, computed tomography) as well as innovation in technologies of in-vivo diagnosis. Cardiac Tumor Pathology presents a spectacular example of these advances with clinico-pathologic correlations. This timely volume covers history, epidemiology, demographics, clinical diagnosis, pathology, imaging by echo, CT and MRI of both benign and malignant cardiac tumors, either primary or secondary. Chemotherapy of malignant neoplasms is also addressed. Special emphasis is given to clinico-pathologic correlations. With all chapters written by experts in their fields, this volume will serve as a useful resource for physicians dealing with, and interested in, this special branch of cardiac oncology and will represent a useful guide for pathologists, clinicians, cardiologists, cardiac surgeons, and radiologists as well as for postgraduate students training in these areas.
Contents
Cardiac Tumors: From Autoptic Observations to Surgical Pathology in the Era of Advanced Cardiac -- Cardiac Tumors: Classification and Cardiac Myxoma -- Other Benign Cardiac Tumors -- Primary Cardiac Tumors in the Pediatric -- Primary Malignant Tumors of the Heart -- Echocardiographic Approach to the Diagnosis of Cardiac -- Echocardiography of Cardiac Masses: From Two- to Three-Dimensional Imaging -- New Cardiac Imaging Techniques: Magnetic Resonance and Computed -- Surgical Management of Cardiac Neoplasms -- Cardiac -- Systemic Therapy, Radiotherapy, and Cardiotoxicity -- Novelties in Immunohistochemical and Molecular Study of Cardiac Tumors – Index.
Format
e-Book
Location
Online
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Cutaneous Neural Neoplasms : A Practical Guide

https://libcat.nshealth.ca/en/permalink/provcat28991
by Zsolt Argenyi, Chris H. Jokinen. --Totowa, NJ: Springer Science+Business Media , c2011.
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Location
Online
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Author
Argenyi, Zsolt
Other Authors
Jokinen, Chris H
Responsibility
by Zsolt Argenyi, Chris H. Jokinen
Place of Publication
Totowa, NJ
Publisher
Springer Science+Business Media
Date of Publication
c2011
Series Title
Current clinical pathology
ISBN
9781603275828
Subjects (MeSH)
Peripheral Nervous System Neoplasms - diagnosis
Peripheral Nervous System Neoplasms - pathology
Skin Neoplasms - diagnosis
Skin Neoplasms - pathology
Subjects (LCSH)
Dermatology
Neurology
Oncology
Format
e-Book
Location
Online
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Cytology and Surgical Pathology of Gynecologic Neoplasms

https://libcat.nshealth.ca/en/permalink/provcat28042
edited by David Chhieng, Pei Hui. --Totowa, NJ: Springer Science+Business Media , c2011.
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Location
Online
Available Online
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Author
Chhieng, David
Other Authors
Hui, Pei
Responsibility
edited by David Chhieng, Pei Hui
Place of Publication
Totowa, NJ
Publisher
Springer Science+Business Media
Date of Publication
c2011
Series Title
Current clinical pathology
ISBN
9781607611646
Subjects (MeSH)
Genital Neoplasms, Female - diagnosis
Genital Neoplasms, Female - pathology
Subjects (LCSH)
Oncology
Pathology
Gynecology
Format
e-Book
Location
Online
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Diagnostic and Prognostic Biomarkers and Therapeutic Targets in Melanoma

https://libcat.nshealth.ca/en/permalink/provcat30996
Michael J. Murphy, editor. --New York, NY: Springer , c2012.
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Online
This book describes both the technologies used in the discovery of melanoma biomarkers and the clinical application of these biomarkers for diagnosis and staging of disease, determination of prognosis, treatment planning, monitoring of response to therapy, identification of novel therapeutic targets and drug development. A broad range of biomarkers (DNA/chromosomal, mRNA, microRNA, mitochondrial DNA, epigenetic and protein) is outlined. As therapies for melanoma become increasingly more target …
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Other Authors
Murphy, Michael J
Responsibility
Michael J. Murphy, editor
Place of Publication
New York, NY
Publisher
Springer
Date of Publication
c2012
Physical Description
1 online resource (xiv, 322 p. : 29 ill., 24 ill. in color)
Series Title
Current clinical pathology
ISBN
9781607614333
Subjects (MeSH)
Drug Delivery Systems
Drug Design
Melanoma - diagnosis
Melanoma - therapy
Tumor Markers, Biological
Subjects (LCSH)
Dermatology
Oncology
Pathology
Abstract
This book describes both the technologies used in the discovery of melanoma biomarkers and the clinical application of these biomarkers for diagnosis and staging of disease, determination of prognosis, treatment planning, monitoring of response to therapy, identification of novel therapeutic targets and drug development. A broad range of biomarkers (DNA/chromosomal, mRNA, microRNA, mitochondrial DNA, epigenetic and protein) is outlined. As therapies for melanoma become increasingly more target specific, the identification, validation and use of biomarkers will invariably play a greater role in the management of patients with this disease. Diagnostic and Prognostic Biomarkers and Therapeutic Targets in Melanoma is an essential resource for oncologists, dermatologists, dermatopathologists, general pathologists with an interest in melanoma, and melanoma researchers.
Contents
Introduction to Diagnostic and Prognostic Biomarkers and Therapeutic Targets in Melanoma -- Diagnostic and Prognostic Biomarkers in Melanoma: Current State of Play -- Molecular Pathogenesis of Melanoma: Established and Novel Pathways -- Staging of Melanoma -- Clinical and Histopathological Parameters in Melanoma -- Genetic/Epigenetic Biomarkers: Distinction of Melanoma from Other Melanocytic Neoplasms -- mRNA Biomarkers in Melanoma -- Epigenetic Biomarkers in Melanoma -- microRNA Biomarkers in Melanoma -- MicroRNAs as Biomarkers and Therapeutic Targets in Melanoma -- Mitochondrial DNA Biomarkers in Melanoma -- Tissue-Based Protein Biomarkers in Melanoma: Immunohistochemistry: (A) Diagnosis -- Tissue-Based Protein Biomarkers in Melanoma: Immunohistochemistry: (B) Prognostication -- Tissue-Based Protein Biomarkers in Melanoma: Mass Spectrometry-Based Strategies -- Serological Biomarkers in Melanoma -- Molecular Markers of Lymph Node Disease in Melanoma -- Melanoma Cell Propagation: Cancer Stem Cell, Clonal Evolution and Interconversion Models of Tumorigenicity -- Surgical Management of Melanoma: Concept of Field Cancerization and Molecular Evaluation of Tissue Margins -- Chemotherapy for Melanoma -- Molecular-Targeted Therapy for Melanoma -- Anti-Angiogenesis Therapy for Melanoma -- Immunological Biomarkers and Immunotherapy for Melanoma -- Diagnostic and Prognostic Biomarkers and Therapeutic Targets in Melanoma: An Overview.
Format
e-Book
Location
Online
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Diagnostic, Prognostic and Therapeutic Value of Gene Signatures

https://libcat.nshealth.ca/en/permalink/provcat31007
Antonio Russo, Stefano Iacobelli, Juan Iovanna, editors. --New York, NY: Humana Press , c2012.
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Gene expression studies have revealed diagnostic profiles and upregulation of specific pathways in many solid tumors. The explosion of new information in gene expression profiling could potentially lead to the development of tailored treatments in many solid tumors. In addition many studies are ongoing to validate these signatures also in predicting response to hormonal, chemotherapeutic and targeted agents in breast cancer as well as in other tumors. Diagnostic, Prognostic and Therapeutic Val…
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Other Authors
Russo, Antonio
Iacobelli, Stefano
Iovanna, Juan
Responsibility
Antonio Russo, Stefano Iacobelli, Juan Iovanna, editors
Place of Publication
New York, NY
Publisher
Humana Press
Date of Publication
c2012
Physical Description
1 online resource (xi, 182 p. : 28 ill., 24 ill. in color)
Series Title
Current clinical pathology
ISBN
9781617793585
Subjects (MeSH)
Gene expression profiling
Genes, neoplasm - genetics
Subjects (LCSH)
Medical laboratories
Genetics
Oncology
Abstract
Gene expression studies have revealed diagnostic profiles and upregulation of specific pathways in many solid tumors. The explosion of new information in gene expression profiling could potentially lead to the development of tailored treatments in many solid tumors. In addition many studies are ongoing to validate these signatures also in predicting response to hormonal, chemotherapeutic and targeted agents in breast cancer as well as in other tumors. Diagnostic, Prognostic and Therapeutic Value of Gene Signatures provides readers a useful and comprehensive resource about the range of applications of microarray technology in oncological diseases. Topics covered include gene signatures and soft tissue sarcomas, prognostic relevance of breast cancer signatures, gene expression profiling of colorectal cancer and liver metastasis, gene signatures in GISTs, CNVs and gene expression profiles in pancreatic cancer, and gene signatures in head/neck, lung and gastric tumors. Diagnostic, Prognostic and Therapeutic Value of Gene Signatures will be of great value to residents and fellows, physicians, pathologists andá medical oncologists.
Contents
Preface -- Gene signatures and soft tissue sarcomas: status of art and perspectives -- Heterogeneity of breast cancer: gene signatures and beyond -- Gene signatures in CRC and liver metastasis -- Gene signatures in gastrointestinal stomal tumors (GIST) -- Pancreatic cancer genetics -- Diagnostic, prognostic and therapeutic value of gene signatures in non-small-cell lung cancer -- Gene signatures in gastric cancer -- Gene signatures in colorectal cancer -- The role of epigenetics in cancer: from molecular function to high-throughput assays -- Primary epithelial ovarian neoplasms: new concepts concerning origin, pathogenesis and classification based on morphology, immunomarkers, molecular features and gene expression studies -- Thyroid carcinoma: molecular signature by histotype specific mutations and gene expression patterns.
Format
e-Book
Location
Online
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Gastric Cancer In The Precision Medicine Era : Diagnosis and Therapy

https://libcat.nshealth.ca/en/permalink/provcat44285
Vincenzo Canzonieri, Antonio Giordano, editors. --Cham: Humana Press , 2019.
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This book provides a comprehensive, state-of-the art review and serves as an overview of the different aspects of gastric cancer. The first section aims to clarify the main aspects of tumorigenesis, such as the role of inflammation linked to the presence of H. Pylori infection, and the genetic and epigenetic mechanisms so far known. Secondly, an exhaustive overview of the diagnosis of gastric cancer from a clinical/endoscopic and pathologic perspective will be illustrated. The second section in…
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Other Authors
Canzonieri, Vincenzo
Giordano, Antonio
Responsibility
Vincenzo Canzonieri, Antonio Giordano, editors
Place of Publication
Cham
Publisher
Humana Press
Date of Publication
2019
Physical Description
1 online resource (xv, 256 p.: 47 illus. in color
Series
Current Clinical Pathology
Series Title
Current clinical pathology
ISBN
9783030048617
9783030048600 (Print ed.)
9783030048624 (Print ed.)
ISSN
2197-781X
Subjects (MeSH)
Biomarkers
Precision Medicine
Stomach Neoplasms - diagnosis
Stomach Neoplasms - therapy
Specialty
Gastroenterology
Medical Oncology
Precision Medicine
Abstract
This book provides a comprehensive, state-of-the art review and serves as an overview of the different aspects of gastric cancer. The first section aims to clarify the main aspects of tumorigenesis, such as the role of inflammation linked to the presence of H. Pylori infection, and the genetic and epigenetic mechanisms so far known. Secondly, an exhaustive overview of the diagnosis of gastric cancer from a clinical/endoscopic and pathologic perspective will be illustrated. The second section includes the pathological and clinical features and contains information regarding the most recent tissue and serological biomarkers in these neoplasms. The three successive sections are intended to provide the “state of art” of multimodal treatment approaches to gastric cancer, i.e. standard and novel surgical aspects, common and innovative chemo and radio protocols and modern targeted therapies. Novel molecular classifications are under consideration to improve diagnostic and prognostic definitions and to prospect future treatments based on the use of immunotherapies and innovative molecules such as non-coding RNA and nanoparticles. Gastric Cancer in the Precision Medicine Era serves as a useful resource for physicians and researchers dealing with, and interested in, this challenging malignancy. It provides a concise yet comprehensive summary of the current status of the field that helps guide patient management and stimulates investigative efforts. All chapters are written by experts in their fields and includes the most up to date scientific and clinical information.
Contents
Part I. Gastric Tumorigenesis -- Gastric Tumorigenesis: Role of Inflammation and Helicobacter Pylori -- Genetic and Epigenetic Mechanisms in Gastric Cancer -- Part II. Clinical and Pathological Characteristics -- Diagnosis and Surveillance: Endoscopic Hallmarks -- Pathological Diagnosis And Classification Of Gastric Epithelial Tumors -- Diagnostic, Prognostic, Predictive and Therapeutic Tissue Biomarkers in Gastric Cancer -- Serum Biomarkers in Gastric Cancer -- Part III. Gastric Cancer Therapy: Multimodal Treatment Approach -- New Agents in the Treatment of Advanced Gastric Cancer: Targeted Therapy and Immunotherapy -- Combined-Modality Treatment for Locally Advanced Gastric Cancer: Current Evidences and New Perspectives -- Surgical Strategies in Gastric Cancer -- Part IV. Evolving Treatment Landscape in Gastric Cancer -- From Molecular Classification to Targeted Therapy for Gastric Cancer in the Precision Medicine Era -- Part V. Future Medicine in Gastric Cancer -- Non-Coding RNA in Gastric Cancer with Potential Prognostic and Predictive Role -- Immunomodulation and Immunotherapy for Gastric Cancer -- Nanomedicine in Gastric Cancer.
Format
e-Book
Location
Online
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Gestational Trophoblastic Disease : Diagnostic and Molecular Genetic Pathology

https://libcat.nshealth.ca/en/permalink/provcat31010
Pei Hui, editor. --New York, NY: Springer , c2012.
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In this volume Dr Hui has brought together a comprehensive overview of gestational trophoblastic disease that includes all the currently recognized entities: complete and partial hydatidiform moles, placental site trophoblastic tumor, epithelioid trophoblastic tumor, gestational choriocarcinoma, persistent gestational trophoblastic neoplasia, placental site nodule and exaggerated placental site reaction. Each entity is reviewed in detail, with emphasis on genetic background, clinical presentati…
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Other Authors
Hui, Pei
Responsibility
Pei Hui, editor
Place of Publication
New York, NY
Publisher
Springer
Date of Publication
c2012
Physical Description
1 online resource (xiii, 205 p. : 104 ill., 96 ill. in color)
Series Title
Current clinical pathology
ISBN
9781617793943
Subjects (MeSH)
Gestational Trophoblastic Disease - pathology
Molecular Diagnostic Techniques
Pathology, Molecular - methods
Subjects (LCSH)
Pathology
Gynecology
Oncology
Abstract
In this volume Dr Hui has brought together a comprehensive overview of gestational trophoblastic disease that includes all the currently recognized entities: complete and partial hydatidiform moles, placental site trophoblastic tumor, epithelioid trophoblastic tumor, gestational choriocarcinoma, persistent gestational trophoblastic neoplasia, placental site nodule and exaggerated placental site reaction. Each entity is reviewed in detail, with emphasis on genetic background, clinical presentation, pathologic findings and ancillary studies, differential diagnosis and clinicopathological correlations. Descriptions of the pathology are supported by numerous excellent photomicrographs. Recent advances in our understanding of the genetics of gestational trophoblastic diseases are stressed. Introductory chapters cover the developmental biology of the placenta and the genetic basis of gestational trophoblastic disease, and one chapter is devoted to the molecular diagnosis of gestational trophoblastic disease. This chapter includes a review of the use of short tandem repeat (STR) genotyping which is of particular value in the diagnosis of hydatidiform moles. The final chapter covers clinical aspects of gestational trophoblastic disease, including treatment. The text throughout is current and thoroughly referenced. This book will be of great value to pathologists, community gynecologists, gynecological pathologists and medical students.
Contents
Gestational trophoblastic disease: general aspects -- Developmental biology of the placenta -- Genetic basis of gestational trophoblastic disease -- Complete hydatidiform mole -- Partial hydatidiform mole -- Placental site trophoblastic tumor -- Epithelioid trophoblastic tumor -- Gestational choriocarcinoma -- Persistent trophoblastic neoplasia -- Tumor-like trophoblastic conditions -- Molecular diagnosis of gestational trophoblastic disease -- Clinical aspects of gestational trophoblastic disease.
Format
e-Book
Location
Online
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Kidney development in renal pathology

https://libcat.nshealth.ca/en/permalink/provcat34051
Gavino Faa, Vassilios Fanos, editors. --New York: Humana Press , c2014.
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This volume provides a comprehensive, state-of-the art review in the field of experimental and human nephrogenesis. The book reviews new data on the effects on kidney development by neonatal asphyxia, obstructive uropathies, nephrotoxic drugs, malnutrition, underfeeding, overfeeding, and provides all possible preventive measures to ensure the well-being of the kidney at birth. The book also discusses the possible implications between renal development and the insurgence of kidney disease in adu…
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Other Authors
Faa, Gavino
Fanos, Vassilios
Responsibility
Gavino Faa, Vassilios Fanos, editors
Place of Publication
New York
Publisher
Humana Press
Date of Publication
c2014
Physical Description
1 online resource (xii, 105 pages)
Series Title
Current clinical pathology
ISBN
9781493909476 (electronic bk.)
9781493909469
Subjects (MeSH)
Kidney Diseases - pathology
Kidney - growth & development
Subjects (LCSH)
Kidneys - Diseases
Kidneys - Growth
Pathology
Nephrology
Abstract
This volume provides a comprehensive, state-of-the art review in the field of experimental and human nephrogenesis. The book reviews new data on the effects on kidney development by neonatal asphyxia, obstructive uropathies, nephrotoxic drugs, malnutrition, underfeeding, overfeeding, and provides all possible preventive measures to ensure the well-being of the kidney at birth. The book also discusses the possible implications between renal development and the insurgence of kidney disease in adult life, and the correlation with renal carcinogenesis.
Contents
Development of the Human Kidney: Morphological Events -- Molecular Regulation of Kidney Development -- Development of the the Human Kidney: Immunohistochemical Findings -- Kidney Development: New Insights on Transmission Electron Microscopy -- The Human Kidney at Birth: Structure and Function in Transition -- Perinatal Asphyxia and Kidney Development -- Lessons on Kidney Development from Experimental Studies -- Do ß-Thymosins Play a Role in Human Nephrogenesis? -- Malnutrition and Renal Function.
Format
e-Book
Location
Online
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Liquid Biopsy in Cancer Patients : The Hand Lens for Tumor Evolution

https://libcat.nshealth.ca/en/permalink/provcat41777
Antonio Russo, Antonio Giordano, Christian Rolfo, editors. --Cham: Humana Press , 2017.
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Online
This text is designed to provide readers with a useful and comprehensive resource and state-of-the-art overview about the new, growing and fast-expanding field of "liquid biopsy" for the management of cancer patients. The liquid biopsy represents an important turning point in oncology since it provides a tool for a serial monitoring of disease. Liquid biopsy is our "hand lens" to follow molecular changes that characterize tumor development and progression. The book provide a unique and valuable…
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Other Authors
Russo, Antonio
Giordano, Antonio
Rolfo, Christian
Responsibility
Antonio Russo, Antonio Giordano, Christian Rolfo, editors
Place of Publication
Cham
Publisher
Humana Press
Date of Publication
2017
Physical Description
1 online resource (xi, 214 pages) : 41 illus., 40 illus. in color
Series Title
Current clinical pathology
ISBN
9783319556611
9783319556598 (print ed.)
ISSN
2197-781X
Subjects (MeSH)
Body Fluids - analysis
Circulating Tumor DNA - analysis
Liquid Biopsy
Neoplasms - diagnosis
Neoplastic cells, circulating
Abstract
This text is designed to provide readers with a useful and comprehensive resource and state-of-the-art overview about the new, growing and fast-expanding field of "liquid biopsy" for the management of cancer patients. The liquid biopsy represents an important turning point in oncology since it provides a tool for a serial monitoring of disease. Liquid biopsy is our "hand lens" to follow molecular changes that characterize tumor development and progression. The book provide a unique and valuable resource on the clinical relevance of liquid biopsy as well as on the technical aspects of liquid biopsy analysis. All invited authors are recognized experts in their field. Liquid Biopsy in Cancer Patients: The Hand Lens for Tumor Evolution is targeted to resident and fellows physicians, medical oncologists, molecular biologists and biotechnologists.
Contents
Introduction -- Precision Medicine: Are We There? -- Clonal Cancer Evolution and Intra-tumor Heterogeneity -- Tissue vs. Liquid Biopsy: Opposite or Complementary? -- Technical Aspects for the Evaluation of Circulating Tumor Cells (CTCs) -- Technical Aspects for the Evaluation of Circulating Nucleic Acids (CNA): Circulating Tumor DNA (ctDNA) and Circulating MicroRNAs -- Technical Aspects for the Evaluation of Exosome and their Content -- Liquid Biopsy in Breast Cancer -- Liquid Biopsy in Head and Neck Cancers -- Liquid Biopsy in NSCLC -- Liquid Biopsy in Gastric Cancer -- Liquid Biopsy in Pancreatic Cancer -- Liquid Biopsy in HCC -- Liquid Biopsy in CRC -- Liquid Biopsy in GIST -- Liquid Biopsy in Kidney Cancer -- Liquid Biopsy in Melanoma.
Format
e-Book
Location
Online
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Lung Pathology : A Consultative Atlas

https://libcat.nshealth.ca/en/permalink/provcat28365
by Stuart Houser, Ulysses J. Balis, Eugene J. Mark. --Totowa, NJ: Humana Press , c2005.
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Location
Online
Available Online
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Author
Houser, Stuart
Other Authors
Balis, Ulysses J
Mark, Eugene J
Responsibility
by Stuart Houser, Ulysses J. Balis, Eugene J. Mark
Place of Publication
Totowa, NJ
Publisher
Humana Press
Date of Publication
c2005
Series Title
Current clinical pathology
ISBN
9781592599370
Subjects (MeSH)
Lung Diseases - Atlases
Subjects (LCSH)
Pneumology
Pathology
Format
e-Book
Location
Online
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The Mediastinal Mass : A Multidisciplinary Approach

https://libcat.nshealth.ca/en/permalink/provcat42628
Renato Franco, Federica Zito Marino, Antonio Giordano, editors. --Cham: Humana Press , c2018.
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Location
Online
This book discusses the main approaches for mediastinal mass diagnosis and treatment, whose different aspects have been thoroughly treated by a multidisciplinary team of experts from different clinical fields. The complex anatomy of the mediastinum, as well as the different clinical, radiographic and prognostic features of mediastinal tumors suggests that specialists adopt more flexible and comprehensive practices, as highlighted in this text. The book includes a brief introductory section desc…
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Other Authors
Franco, Renato
Zito Marino, Federica
Giordano, Antonio
Responsibility
Renato Franco, Federica Zito Marino, Antonio Giordano, editors
Place of Publication
Cham
Publisher
Humana Press
Date of Publication
c2018
Physical Description
1 online resource (xii, 309 p.) : 97 illus., 78 illus. in color
Series Title
Current clinical pathology
ISBN
9783319903682
9783319903675 (print ed.)
9783319903699 (print ed.)
ISSN
2197-781X
Subjects (MeSH)
Mediastinal Neoplasms
Specialty
Medical Oncology
Abstract
This book discusses the main approaches for mediastinal mass diagnosis and treatment, whose different aspects have been thoroughly treated by a multidisciplinary team of experts from different clinical fields. The complex anatomy of the mediastinum, as well as the different clinical, radiographic and prognostic features of mediastinal tumors suggests that specialists adopt more flexible and comprehensive practices, as highlighted in this text. The book includes a brief introductory section describing the anatomic sites of mediastinal masses and the epidemiological evidence for each different clinical-pathological entity. In particular, specific chapters are dedicated to thymic tumors, lymphomas, thyroid and parathyroid masses, and germ cell tumors of the anterior mediastinum. The Mediastinal Mass: A Multidisciplinary Approach provides a valuable resource for clinicians, surgeons, radiologists and pathologists dealing with the management and treatment of mediastinal masses through a multidisciplinary approach.
Contents
Introduction: Epidemiology, Mediastinal Anatomy, Mediastinal Masses -- Clinical Approach: Recommendations for the Clinicians -- Mediastinal Masses: Radiological Point of View -- Radiotherapy in Anterior Mediastinum Cancers -- Surgery: Reccomandations for Surgeons -- Diagnostic Histopathology Approach -- Thymic Tumors and Lymphomas: The Clinical Impact of their Underlying Molecular Features -- Therapy: Recommendations for the Oncologists -- Thymic Neoplasm -- Primitive Mediastinal Germ Cell Tumors: An Update -- Thyroid -- Parathyroid -- Mediastinal Lymphoma -- Granulomatous Disease -- Cysts of The Middle Mediastinum -- Tracheal Tumors -- Nerve Sheath Tumors, Ganglion Tumours and Neurenteric Cysts -- Esophageal Tumors.
Format
e-Book
Location
Online
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Molecular Diagnostics in Dermatology and Dermatopathology

https://libcat.nshealth.ca/en/permalink/provcat29555
edited by Michael J. Murphy. --Totowa, NJ: Springer Science+Business Media , c2011.
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Location
Online
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Author
Murphy, Michael J
Responsibility
edited by Michael J. Murphy
Place of Publication
Totowa, NJ
Publisher
Springer Science+Business Media
Date of Publication
c2011
Series Title
Current clinical pathology
ISBN
9781607611714
Subjects (MeSH)
Molecular Diagnostic Techniques - methods
Skin Diseases - diagnosis
Skin Diseases - genetics
Skin - pathology
Subjects (LCSH)
Dermatology
Pathology
Format
e-Book
Location
Online
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Radiobiology of Glioblastoma : Recent Advances and Related Pathobiology

https://libcat.nshealth.ca/en/permalink/provcat40082
Luigi Pirtoli, Giovanni Luca Gravina, Antonio Giordano, editors. --Cham: Springer International Publishing : Imprint: Humana Press , c2016.
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Location
Online
This text properly considers the most recent and relevant advances in molecular RB of GB, taking into account the related topics of pathobiology, and underscores the most promising translational perspectives from the preclinical to the clinical domain. Section I (From Bedside to Bench) discusses conditions associated with RT resistance of GB and the consequent RB hints, technology improvements intended to overcome RT-resistance of GB, mathematical modeling of RB parameters from clinical studies…
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Other Authors
Pirtoli, Luigi
Gravina, Giovanni Luca
Giordano, Antonio
Responsibility
Luigi Pirtoli, Giovanni Luca Gravina, Antonio Giordano, editors
Place of Publication
Cham
Publisher
Springer International Publishing : Imprint: Humana Press
Date of Publication
c2016
Physical Description
1 online resource (xx, 305 p. : 49 illus., 39 illus. in color)
Series Title
Current clinical pathology
ISBN
9783319283050
9783319283036 (print ed.)
ISSN
2197-781X
Subjects (MeSH)
Glioblastoma - radiotherapy
Radiobiology
Abstract
This text properly considers the most recent and relevant advances in molecular RB of GB, taking into account the related topics of pathobiology, and underscores the most promising translational perspectives from the preclinical to the clinical domain. Section I (From Bedside to Bench) discusses conditions associated with RT resistance of GB and the consequent RB hints, technology improvements intended to overcome RT-resistance of GB, mathematical modeling of RB parameters from clinical studies, the present impact of molecular prognostic factors in therapy of GB, and RT tolerance of normal brain. Section II (Preclinical Research and Pathobiology Topics) presents the traditional and mechanistic/molecular approaches to RB of GB, genetic and epigenetic studies on GB, issues of cell-death pathways, stem-like cells, invasiveness, tumor microenvironment, hypoxia, mi-RNA manipulations, and nanoparticle technology. Section III (Translational Perspectives) presents RB issues related to molecular profiling and classification of GB as frames of reference for clinical studies, translational perspectives of gene therapy, evolving protocols based on pre-clinical data and large data-bases and ontologic models. Radiobiology of Glioblastoma: Recent Advances and Related Pathobiology will be of great value to pathologists, medical oncologists, radiation oncologists as well as basic researchers and clinical investigators.
Contents
Introduction and Background -- Part I. From Bedside to Bench: Radiobiological Topics Arising from Clinical Studies -- The "Radio-resistance" of Glioblastoma in the Clinical Setting, and the Present Therapeutic Options -- Radiobiological Hints from Clinical Studies -- Chemo-radiotherapy: Radiation Total Dose and Fractionation -- Clinical Evidence and Radiobiological Background of Particle Radiation Therapy -- Mathematical Modeling of Radiobiological Parameters from Clinical Studies -- Clinical, Pathology and Molecular Prognostic Parameters of Response to Chemo- and Radiotherapy from Clinical Series -- Radiation Tolerance of Normal Brain: QUANTEC 2010 and Beyond -- Part II. Preclinical Research -- Basic Knowledge of Glioblastoma Radiobiology -- Molecular Radiobiology and Mathematical Modeling -- Genetic and Epigenetic Determinants in Tumor Initiation and Progression -- Tumor Microenvironment -- Cell Death Pathways, with Special Regard to Ionizing Radiation and Temozolomide Therapy -- mi-RNA Manipulation in Modifying Radiation Sensitivity in Glioblastoma Models -- Glioma Stem-like Cells and Radiation Resistance -- Hypoxia and Radiation Resistance -- Invasiveness and Radiation Failures -- Nanoparticle Technology for Research Radiobiology -- The Molecular Classification of Glioblastoma as a Translational Instrument -- Translational Perspectives for Gene Therapy -- Part III. From Bench to Bedside: Translational Perspectives -- Pre-Clinical Models of Glioblastoma in Radiobiology: Evolving Protocols and Research Methods -- From Molecular to Clinical Radiation Biology -- Perspectives of the Large Data-Bases and Ontologic Models of Correlation of Pre-clinical and Clinical Results -- Conclusive Remarks and Perspectives for Future Research.
Format
e-Book
Location
Online
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Skin Cancer : A Practical Approach

https://libcat.nshealth.ca/en/permalink/provcat39587
Alfonso Baldi, Paola Pasquali, Enrico P Spugnini, editors. --New York, NY: Springer New York : Imprint: Humana Press , c2014.
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Online
Skin Cancer: A Practical Approach presents a comprehensive and up to date overview on skin cancer. With an emphasis on practical aspects that will set the basis for guidelines of treatment, the volume presents different diagnostic tools to help physicians obtain the proper diagnosis. Written by a worldwide base of experts selected on their recognized expertise on the different themes discussed, Skin Cancer: A Practical Approach is a valuable resource for investigators in the field of skin cance…
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Other Authors
Baldi, Alfonso
Pasquali, Paola
Spugnini, Enrico P
Responsibility
Alfonso Baldi, Paola Pasquali, Enrico P Spugnini, editors
Place of Publication
New York, NY
Publisher
Springer New York : Imprint: Humana Press
Date of Publication
c2014
Physical Description
1 online resource (xiv, 569 p. : 270 illus., 222 illus. in color)
Series Title
Current clinical pathology
ISBN
9781461473572
9781461473565 (print ed.)
Subjects (MeSH)
Skin Neoplasms
Abstract
Skin Cancer: A Practical Approach presents a comprehensive and up to date overview on skin cancer. With an emphasis on practical aspects that will set the basis for guidelines of treatment, the volume presents different diagnostic tools to help physicians obtain the proper diagnosis. Written by a worldwide base of experts selected on their recognized expertise on the different themes discussed, Skin Cancer: A Practical Approach is a valuable resource for investigators in the field of skin cancer, including pathologists, medical and surgical oncologists, dermatologists, general surgeons, and veterinary oncologists.
Contents
Embryology and Anatomy of the Skin -- Epidemiology And Prevention Of Cutaneous Tumors -- Cutaneous Squamous Cell Carcinoma: focus on biochemical and molecular characteristics -- Molecular Pathology Of Melanocytic Skin Cancer -- Basal Cell Carcinoma: molecular and pathological features -- Skin Adnexal tumors: a large spectrum of clinic-pathological lesions -- Pathology of Melanocytic Skin Tumors -- Pathology Of Other Skin Cancer -- Primary Cutaneous Lymphomas -- Comparative Oncology of Skin Cancer -- Clinical-pathological integration in the diagnosis of skin cancer -- Cytology -- Dermoscopy -- Introduction to Ultrasonography in Skin Cancer -- Use of 22 MHz High Frequency Ultrasound in the management of skin cancer -- Optical Coherence Tomography -- Reflectance Confocal Microscopy in Skin Cancer -- Multiphoton Laser Microscopy with Fluorescence Lifetime Imagin -- Cryosurgery -- Immunological aspects of cryosurgery -- Photodynamic Therapy -- Lasers for Skin Cancer -- Radiation therapy in Dermatology -- Electrochemotherapy in dermatological oncology -- Systemic Treatment of Primary Cutaneous Lymphomas -- Systemic therapy in melanoma -- Systemic Therapy for Rare Tumours of the Skin and Soft Tissue Tumour -- Sentinel Lymph Node -- Sunlight-Induced Skin Cancer In Companion Animals -- Telemedicine and skin cancer: Teledermatology and Teledermoscopy -- Automated Content-Based Image Retrieval: Application On Dermoscopic Images Of Pigmented Skin Lesions -- Gene Expression Profiling in Melanoma.
Format
e-Book
Location
Online
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Surgical Pathology of Endocrine and Neuroendocrine Tumors

https://libcat.nshealth.ca/en/permalink/provcat29828
edited by Ashraf Khan. --Totowa, NJ: Humana Press , c2009.
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Location
Online
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Author
Khan, Ashraf
Responsibility
edited by Ashraf Khan
Place of Publication
Totowa, NJ
Publisher
Humana Press
Date of Publication
c2009
Series Title
Current clinical pathology
ISBN
9781603273961
Subjects (MeSH)
Endocrine Gland Neoplasms - diagnosis
Neuroendocrine Tumors - diagnosis
Neuroendocrine Tumors - pathology
Pathology, Surgical - methods
Format
e-Book
Location
Online
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