This book describes the recent developments in the emerging field of cancer stem cells. Their possible impact for the identification of novel treatment paradigms for cancer are discussed.
Niche for Normal and Cancer Stem Cells -- c-Myc and Activated Ras During Skin Tumorigenesis: Cooperation at the Cancer Stem Cell Level? -- Wnt Signaling in Stem Cells and Lung Cancer -- Bone Morphogenetic Proteins Regulate Tumorigenicity in Human Glioblastoma Stem Cells -- Strategies to Induce Nuclear Reprogramming -- The Intestinal Stem Cell Niche Studied Through Conditional Transgenesis -- The Migrating Cancer Stem Cells Model - A Conceptual Explanation of Malignant Tumour Progression -- Bone Marrow Niche and Leukemia -- Breast Stem Cells and Cancer -- Prostate Cancer Stem Cells: A Target for New Therapies -- The Hedgehog Signaling Network, Mammary Stem Cells, and Breast Cancer: Connections and Controversies -- Strategies to Eliminate Cancer Stem Cells -- DNA Repair in Stem Cell Maintenance and Conversion to Cancer Stem Cells -- Tumorigenic Epithelial Stem Cells and Their Normal Counterparts.
Nature's Choice of Genes Controlling Chronic Inflammation -- Targeting of Memory -- Post-transcriptional Regulators in Inflammation: Exploring New Avenues in Biological Therapeutics -- Immunomodulatory Therapies: Challenges of Individualized Therapy Strategies -- T Cell Therapies -- The Future of Antibody Therapy.