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Basic Concepts of Molecular Pathology

https://libcat.nshealth.ca/en/permalink/provcat28227
edited by Timothy Craig Allen, Philip T. Cagle. --Boston, MA: Springer US , c2009.
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Online
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Author
Allen, Timothy Craig
Other Authors
Cagle, Philip T
Responsibility
edited by Timothy Craig Allen, Philip T. Cagle
Place of Publication
Boston, MA
Publisher
Springer US
Date of Publication
c2009
Series Vol.
v. 2
Series Title
Molecular pathology library
ISBN
9780387896267
Subjects (MeSH)
Molecular Biology - methods
Pathology, Clinical - methods
Clinical Laboratory Techniques
Subjects (LCSH)
Pathology
Genetics
Biochemistry
Format
e-Book
Location
Online
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Molecular Pathology of Endocrine Diseases

https://libcat.nshealth.ca/en/permalink/provcat29534
edited by Jennifer L. Hunt. --Boston, MA: Springer-Verlag US , c2010.
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Online
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Author
Hunt, Jennifer L
Responsibility
edited by Jennifer L. Hunt
Place of Publication
Boston, MA
Publisher
Springer-Verlag US
Date of Publication
c2010
Series Vol.
v. 3
Series Title
Molecular pathology library
ISBN
9781441917072
Subjects (MeSH)
Endocrine Glands - pathology
Endocrine System Diseases - genetics
Subjects (LCSH)
Endocrinology 
Pathology
Format
e-Book
Location
Online
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Molecular Pathology of Hematolymphoid Diseases

https://libcat.nshealth.ca/en/permalink/provcat30431
edited by Cherie H. Dunphy. --Boston, MA: Springer-Verlag , c2010.
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Online
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Author
Dunphy, Cherie H
Responsibility
edited by Cherie H. Dunphy
Place of Publication
Boston, MA
Publisher
Springer-Verlag
Date of Publication
c2010
Series Vol.
v. 4
Series Title
Molecular pathology library
ISBN
9781441956989
Subjects (MeSH)
Hematologic Neoplasms - pathology
Lymphatic Diseases - pathology
Subjects (LCSH)
Hematology
Oncology
Pathology
Format
e-Book
Location
Online
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Molecular Pathology of Liver Diseases

https://libcat.nshealth.ca/en/permalink/provcat29001
edited by Satdarshan P. S. Monga. --Boston, MA: Springer Science+Business Media , c2011.
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Online
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Author
Monga, Satdarshan P. S
Responsibility
edited by Satdarshan P. S. Monga
Place of Publication
Boston, MA
Publisher
Springer Science+Business Media
Date of Publication
c2011
Series Vol.
v. 5
Series Title
Molecular pathology library
ISBN
9781441971074
Subjects (MeSH)
Liver Diseases - pathology
Liver - physiopathology
Subjects (LCSH)
Pathology
Hepatology
Format
e-Book
Location
Online
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Molecular Pathology of Lung Cancer

https://libcat.nshealth.ca/en/permalink/provcat30969
Philip T. Cagle ... [et al.], editors. --New York, NY: Springer , c2012.
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As with other books in the Molecular Pathology Library Series, Molecular Pathology of Lung Cancer bridges the gap between the molecular specialist and the clinical practitioner, including the surgical pathologist who now has a key role in decisions regarding molecular targeted therapy for lung cancer. Molecular Pathology of Lung Cancer provides the latest information and current insights into the molecular basis for lung cancer, including precursor and preinvasive lesions, molecular diagnosis, …
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Other Authors
Cagle, Philip T
Responsibility
Philip T. Cagle ... [et al.], editors
Place of Publication
New York, NY
Publisher
Springer
Date of Publication
c2012
Physical Description
1 online resource (xi, 216 p. : 46 ill. in color)
Series Vol.
v. 6
Series Title
Molecular pathology library
ISBN
9781461431978
Subjects (MeSH)
Lung Neoplasms - pathology
Molecular Diagnostic Techniques
Molecular Targeted Therapy
Pathology, Molecular - methods
Subjects (LCSH)
Oncology
Pathology
Thoracic surgery
Abstract
As with other books in the Molecular Pathology Library Series, Molecular Pathology of Lung Cancer bridges the gap between the molecular specialist and the clinical practitioner, including the surgical pathologist who now has a key role in decisions regarding molecular targeted therapy for lung cancer. Molecular Pathology of Lung Cancer provides the latest information and current insights into the molecular basis for lung cancer, including precursor and preinvasive lesions, molecular diagnosis, molecular targeted therapy, molecular prognosis, molecular radiology and related fields for lung cancer generally and for the specific cell types. As many fundamental concepts about lung cancer have undergone revision in only the past few years, this book will likely be the first to comprehensively cover the new molecular pathology of lung cancer. It provides a foundation in this field for pathologists, medical oncologists, radiation oncologists, thoracic surgeons, thoracic radiologists and their trainees, physician assistants, and nursing staff.
Contents
Part I. Molecular Pathology of Lung Cancer: General Principles -- Approach to Personalized Care of the Lung Cancer Patient -- Etiology of Lung Cancer -- Genetic Susceptibility to Lung Cancer -- Lung Cancer Stem Cells -- The Classification of Pre-Invasive Lesions -- Molecular Pathology of Precursor and Pre-Invasive Lesions -- Revised Classification for Adenocarcinoma -- Molecular Basis for the Current Lung Cancer Classification -- Molecular Diagnosis of Lung Cancer -- Molecular Targeted Therapy of Lung Cancer -- Molecular Prognostic Markers of Lung Cancer -- New Techniques for Optical and Molecular Visualization of Lung Cancer -- Part II. Molecular Pathology of Lung Cancer: Specific Histologic Types -- Adenocarcinoma -- Squamous Cell Carcinoma -- Molecular Pathology of Large Cell Carcinoma -- Molecular Pathology of Small Cell Carcinomas -- Molecular Biopsy of Neuroendocrine Carcinomas Other Than Small Cell Carcinoma -- Molecular Pathology of Uncommon Carcinomas -- Biology of Lung Cancer Metastases.
Format
e-Book
Location
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Molecular Pathology of Lung Diseases

https://libcat.nshealth.ca/en/permalink/provcat29513
edited by Dani S. Zander, Helmut H. Popper, Jaishree Jagirdar, Abida K. Haque, Philip T. Cagle, Roberto Barrios. --New York, NY: Springer-Verlag , c2008.
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Online
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Author
Zander, Dani S
Other Authors
Popper, Helmut H
Jagirdar, Jaishree
Haque, Abida K
Cagle, Philip T
Barrios, Roberto
Responsibility
edited by Dani S. Zander, Helmut H. Popper, Jaishree Jagirdar, Abida K. Haque, Philip T. Cagle, Roberto Barrios
Place of Publication
New York, NY
Publisher
Springer-Verlag
Date of Publication
c2008
Series Vol.
v. 1
Series Title
Molecular pathology library
ISBN
9780387724300
Subjects (MeSH)
Lung Diseases - genetics
Lung Diseases - pathology
Molecular Biology
Subjects (LCSH)
Pneumology
Pathology
Genetics
Format
e-Book
Location
Online
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Molecular pathology of neoplastic gastrointestinal diseases

https://libcat.nshealth.ca/en/permalink/provcat32439
Antonia R. Sepulveda, John P. Lynch, editors. --New York, NY: Springer , c2013.
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Molecular Pathology of Neoplastic Gastrointestinal Diseases reviews the molecular aspects that characterize the spectrum of neoplastic conditions that affect the gastrointestinal tract, providing the reader with current up-to-date knowledge. For each disease entity chapters provide reviews on: the molecular basis of the individual disease, molecular testing approaches currently available or in development for diagnosis or for gene target characterization for selective targeted therapies, recomm…
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Other Authors
Sepulveda, Antonia R
Lynch, John P
Responsibility
Antonia R. Sepulveda, John P. Lynch, editors
Place of Publication
New York, NY
Publisher
Springer
Date of Publication
c2013
Physical Description
1 online resource (x, 277 p. : 53 ill., 40 ill. in color)
Series Title
Molecular pathology library
ISBN
9781461460152
Subjects (MeSH)
Gastrointestinal Neoplasms - genetics
Gastrointestinal Neoplasms - pathology
Subjects (LCSH)
Gastroenterology
Pathology
Abstract
Molecular Pathology of Neoplastic Gastrointestinal Diseases reviews the molecular aspects that characterize the spectrum of neoplastic conditions that affect the gastrointestinal tract, providing the reader with current up-to-date knowledge. For each disease entity chapters provide reviews on: the molecular basis of the individual disease, molecular testing approaches currently available or in development for diagnosis or for gene target characterization for selective targeted therapies, recommended guidelines for clinical application of molecular tests are included whenever available, molecular testing for hereditary predisposition or disease risk, animal models and cell culture models of disease.
Contents
Section 1. Introduction -- 1. Mechanisms of Gastrointestinal Carcinogenesis -- Section 2. Epithelial Neoplastic Disease -- 2. Targeted Therapies and Molecular Diagnostics of Gastrointestinal Cancers -- 3. Molecular Pathology of Barrett's Metaplasia and Esophageal Adenocarcinoma -- 4. Molecular Pathology of Squamous Carcinomas of the Esophagus -- 5. Molecular Mechanisms and Pathology of Gastric Carcinogenesis: Sporadic Cancers -- 6. Hereditary Diffuse Gastric Cancer and Other Gastric Cancers Associated with Hereditary Predisposition Syndromes -- 7. Cancer Predisposition Syndromes of the Gastrointestinal Tract -- 8. Molecular Pathology of Colon and Small Bowel Cancers: Sporadic Types -- 9. Cancers of the Rectum and Anal Canal -- 10. Molecular Pathology of Inflammatory Bowel Disease Associated Neoplasia -- Section 3. Non-Epithelial Neoplasticá Tumors -- 11. Molecular Biology and Pathology of Gastrointestinal Stromal Tumors -- 12. Neuroendocrine Tumors -- Section 4. Metastatic Disease and Tumor Markers -- 13. Molecular Mechanisms of Tumor Metastases -- 14. Circulating Tumor Cells and Nucleic Acids for Tumor Diagnosis -- 15. Serological Markers of Digestive Tract Cancers.
Format
e-Book
Location
Online
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Molecular Pathology of Nervous System Tumors : Biological Stratification and Targeted Therapies

https://libcat.nshealth.ca/en/permalink/provcat38980
Matthias A. Karajannis, David Zagzag, editors. --New York, NY: Springer , c2015.
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This book serves as a comprehensive guide to the rapidly evolving field of molecular neuropathology of nervous system tumors, as well as the underlying biology and emerging molecular targeted therapies. Special emphasis is given to already established and emerging molecular diagnostic tests in neuropathology, as well as molecular targeted therapies. The book is organized by clinico-pathologic disease entities, and each chapter is written by a team of experts in their field. Molecular Pathology …
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Other Authors
Karajannis, Matthias A
Zagzag, David
Responsibility
Matthias A. Karajannis, David Zagzag, editors
Place of Publication
New York, NY
Publisher
Springer
Date of Publication
c2015
Physical Description
1 online resource (xv, 247 p. : 121 illus., 78 illus. in color)
Series Title
Molecular pathology library
ISBN
9781493918300
9781493918294 (print ed.)
ISSN
1935-987X
Subjects (MeSH)
Biomarkers, Tumor
Central Nervous System Neoplasms - genetics
Central Nervous System Neoplasms - pathology
Central Nervous System Neoplasms - therapy
Molecular Diagnostic Techniques
Molecular Targeted Therapy
Abstract
This book serves as a comprehensive guide to the rapidly evolving field of molecular neuropathology of nervous system tumors, as well as the underlying biology and emerging molecular targeted therapies. Special emphasis is given to already established and emerging molecular diagnostic tests in neuropathology, as well as molecular targeted therapies. The book is organized by clinico-pathologic disease entities, and each chapter is written by a team of experts in their field. Molecular Pathology of Nervous System Tumors is of great value and utility for physicians and scientists involved with or interested in the up-to-date diagnosis and treatment of patients with brain tumors.
Contents
[publisher supplied] 1. Hereditary Predisposition to Primary CNS Tumors -- 2. Brain Tumor Stem Cells -- 3. Molecular Pathology Techniques -- 4. Low-grade Gliomas -- 5. Ependymoma -- 6. Adult High-Grade (Diffuse) Glioma -- 7. High-Grade Gliomas and DIPG (Pediatric) -- 8.Oligodendroglial Tumors: Current Treatments and the Promise of Molecular Genetics -- 9.Molecular Pathology of Nervous System Tumors: Medulloblastoma and CNS Primitive Neuroectodermal Tumors -- 10. Subependymal Giant Cell Astrocytoma -- 11. Germ Cell Tumors -- 12. Choroid Plexus Tumors. -- 13. Atypical Teratoid Rhabdoid Tumors -- 14. Hemangioblastoma -- 15. Schwannomas -- 16. Molecular Pathology of Nervous System Tumors -- 17. Molecular Genetic Pathology of Meningiomas.
Format
e-Book
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Online
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Precision Molecular Pathology of Bladder Cancer

https://libcat.nshealth.ca/en/permalink/provcat42915
edited by Donna E. Hansel, Seth P. Lerner. --Cham, Switzerland: Springer , c2018.
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This succinct yet comprehensive volume describes current and emerging concepts in molecular pathology of bladder cancer. Divided into two distinct sections, the first part focuses on the general principles of molecular findings in bladder cancer, while the second part focuses on the molecular changes associated with specific histologic subtypes. The volume also addresses such topics as molecular alterations in non-invasive and invasive disease, including bladder cancer variants as appropriate, …
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Other Authors
Hansel, Donna E.
Lerner, Seth P.
Responsibility
edited by Donna E. Hansel, Seth P. Lerner
Place of Publication
Cham, Switzerland
Publisher
Springer
Date of Publication
c2018
Physical Description
1 online resource (ix, 243 p.) : 40 illus., 38 illus. in color
Series Title
Molecular pathology library
ISBN
9783319647692
9783319647678 (print ed.)
9783319647685 (print ed.)
9783319878676 (print ed.)
ISSN
1935-987X
Subjects (MeSH)
Pathology, Molecular - methods
Precision Medicine - methods
Urinary Bladder Neoplasms
Specialty
Medical Oncology
Molecular Medicine
Pathology
Precision Medicine
Urology
Abstract
This succinct yet comprehensive volume describes current and emerging concepts in molecular pathology of bladder cancer. Divided into two distinct sections, the first part focuses on the general principles of molecular findings in bladder cancer, while the second part focuses on the molecular changes associated with specific histologic subtypes. The volume also addresses such topics as molecular alterations in non-invasive and invasive disease, including bladder cancer variants as appropriate, emerging molecular classifiers of bladder cancer, and molecular associations to outcome and treatment. Written by experts in the field, Precision Molecular Pathology of Bladder Cancer is a valuable resource for those in the urologic community, including urologic pathologists, urologists, urologic oncologists and radiation oncologists, who treat and manage bladder cancer.
Contents
1. Risk Factors and Molecular Features Associated with Bladder Cancer Development -- 2. Grading, Staging, and Morphologic Risk Stratification of Bladder Cancer -- 3. Genomic Assessment of Muscle-Invasive Bladder Cancer: Insights from The Cancer Genome Atlas (TCGA) Project -- 4. Molecular Alterations in the Pathogenesis of Bladder Cancer Subtypes and Urothelial Carcinoma Variants -- 5. Treatment Paradigms in Bladder Cancer: Clinical Implications of Histological and Molecular Analysis -- 6. Requisite for Collection and Distribution of Tissue and Fluid Specimens for Molecular Diagnostics and Discovery in Bladder Cancer -- 7. Diagnostic, Prognostic and Predictive Biomarkers on Bladder Tissue and Blood -- 8. Urine Cytology and Existing Urinary Biomarkers for Bladder Cancer -- 9. Molecular Targeted Therapy of Bladder Cancer -- 10. Response to Immunotherapy: Application of Molecular Pathology to Predict Successful Response -- 11. Emerging Molecular Approaches in the Analysis of Urine in Bladder Cancer Diagnosis -- 12. Stromal Contributions to Tumor Progression in Urothelial Carcinoma of the Bladder -- 13. Modeling Bladder Cancer with Genetic Engineering: Fidelity of Human-to-laboratory Models.
Format
e-Book
Location
Online
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Precision Molecular Pathology of Breast Cancer

https://libcat.nshealth.ca/en/permalink/provcat39035
Ashraf Khan, Ian O. Ellis, Andrew M. Hanby, Ediz F. Cosar, Emad A. Rakha, Dina Kandil, editors. (1st ed.) --New York, NY: Springer , c2015.
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This volume provides a comprehensive review of the molecular mechanisms involved in precancerous lesions and benign and malignant breast tumors. Given the complex molecular pathways in breast cancer biology, the book simplifies these complex mechanisms and highlights the practical issues important for daily practice. Sections are structured to review breast carcinogenesis and the role of familial predisposition and stem cells in initiation and progression of breast cancer. In-depth chapters pre…
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Other Authors
Khan, Ashraf
Ellis, Ian O
Hanby, Andrew M
Cosar, Ediz F
Rakha, Emad A
Kandil, Dina
Responsibility
Ashraf Khan, Ian O. Ellis, Andrew M. Hanby, Ediz F. Cosar, Emad A. Rakha, Dina Kandil, editors
Edition
1st ed.
Place of Publication
New York, NY
Publisher
Springer
Date of Publication
c2015
Physical Description
1 online resource (x, 338 p. : 29 illus., 28 illus. in color)
Series Vol.
10
Series Title
Molecular pathology library
ISBN
9781493928866
9781493928859 (print ed.)
ISSN
1935-987X
Subjects (MeSH)
Breast neoplasms - pathology
Molecular Diagnostic Techniques
Molecular Targeted Therapy
Pathology, Molecular - methods
Abstract
This volume provides a comprehensive review of the molecular mechanisms involved in precancerous lesions and benign and malignant breast tumors. Given the complex molecular pathways in breast cancer biology, the book simplifies these complex mechanisms and highlights the practical issues important for daily practice. Sections are structured to review breast carcinogenesis and the role of familial predisposition and stem cells in initiation and progression of breast cancer. In-depth chapters present morphologic and molecular correlations in precancerous and malignant breast lesions, while outlining highly practical issues that are in practice today in breast pathology, such as evaluation of estrogen, progesterone receptors, and HER-2. Written by experts in the field, Precision Molecular Pathology of Breast Cancer is a valuable resource that covers the current practice of breast pathology and looks into the future with an emphasis on the molecular basis of breast cancer.
Contents
Molecular basis of breast cancer imaging -- Familial Breast Cancer and Genetic Predisposition in Breast Cancer -- Modelling the Molecular Pathology of Breast Cancer Initiation -- Molecular Pathology of Precancerous Lesions of the Breast -- Breast Cancer Stem Cells: Role in Tumor Initiation, Progression and Targeted Therapy -- Molecular Pathology of Pre-Invasive Ductal Carcinoma -- Molecular Pathology of Lobular Carcinoma -- Molecular Pathology of Hormone Regulation in Breast Cancer: Hormone Receptor Evaluation and Therapeutic Implications -- Molecular Pathology of HER Family of Oncogenes in Breast Cancer: HER-2 Evaluation and Role in Targeted Therapy -- Molecular Classification of Breast Cancer -- Triple-Negative Breast Cancer: Subtypes with Clinical Implications -- Molecular-based Diagnostic, Prognostic and Predictive Tests in Breast Cancer -- Role of MicroRNAs in Breast Cancer -- Molecular Pathology of Fibroepithelial Neoplasms of the Breast -- Molecular Features of Mesenchymal Tumors of the Breast -- Molecular Pathology of Breast Cancer Metastasis -- The molecular pathology of chemoresistance during the therapeutic response in breast cancer -- The Molecular Pathology of Male Breast Cancer -- Specimens for Molecular Testing in Breast Cancer.
Format
e-Book
Location
Online
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Precision Molecular Pathology of Dermatologic Diseases

https://libcat.nshealth.ca/en/permalink/provcat39034
Victor G. Prieto, editor. --New York, NY: Springer , c2015.
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This volume is a concise yet comprehensive resource for physicians dealing with, and interested in, the field of molecular pathology in dermatopathology. The book includes descriptions of the techniques and their application to cutaneous diseases and describes possible future techniques and their use in dermatopathology. Special emphasis is also given to the practical application of these techniques to particular situations illustrated by demonstrative cases. Written by experts in their fields,…
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Prieto, Victor G
Responsibility
Victor G. Prieto, editor
Place of Publication
New York, NY
Publisher
Springer
Date of Publication
c2015
Physical Description
1 online resource (viii, 136 p. : 40 illus., 39 illus. in color)
Series Title
Molecular pathology library
ISBN
9781493928613
9781493928606 (print ed.)
ISSN
1935-987X
Subjects (MeSH)
Molecular Diagnostic Techniques - methods
Pathology, Molecular - methods
Skin Diseases - pathology
Abstract
This volume is a concise yet comprehensive resource for physicians dealing with, and interested in, the field of molecular pathology in dermatopathology. The book includes descriptions of the techniques and their application to cutaneous diseases and describes possible future techniques and their use in dermatopathology. Special emphasis is also given to the practical application of these techniques to particular situations illustrated by demonstrative cases. Written by experts in their fields, Precision Molecular Pathology of Dermatologic Diseases is of great value to pathologists, dermatologists, residents and fellows, internists, and general practitioners who deal with dermatologic diseases.
Contents
Introduction -- Hematolymphoid Proliferations of the Skin -- Molecular Testing in Cutaneous Mesenchymal Tumors -- Molecular Pathology of Cutaneous Adnexal Tumors -- Infectious diseases of the skin -- Application of Molecular Pathology to Cutaneous Melanocytic Lesions -- Application of Molecular Pathology to Tissue Identification in Cutaneous Pathology.
Format
e-Book
Location
Online
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Precision Molecular Pathology of Glioblastoma

https://libcat.nshealth.ca/en/permalink/provcat46815
José Javier Otero, Aline Paixao Becker. Springer , 2021.
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Online
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Responsibility
José Javier Otero, Aline Paixao Becker
Publisher
Springer
Date of Publication
2021
Physical Description
1 online resource (xv, 266 pages) : illustrations
Series Title
Molecular pathology library
ISBN
9783030691707
Specialty
Pathology
Medical Oncology
Format
e-Book
Location
Online
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Precision Molecular Pathology of Hodgkin Lymphoma

https://libcat.nshealth.ca/en/permalink/provcat43258
S. David Hudnall, Ralf Küppers, editors. --Cham: Springer , c2018.
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This text provides a comprehensive and up-to-date overview of Hodgkin lymphoma. The volume reviews every facet of the cancer in great detail, including pathology, pathobiology, molecular genetics, microenvironment, epidemiology, treatment, and new therapeutic advances. The specific role of the lymphoma microenvironment is addressed, and the relationship of Hodgkin lymphoma to related non-Hodgkin lymphomas is covered as well. Written by experts in the field, Precision Molecular Pathology of Hodg…
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Other Authors
Hudnall, S. David
Küppers, Ralf
Responsibility
S. David Hudnall, Ralf Küppers, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2018
Physical Description
1 online resource (x, 236 p.) : 47 illus. in color
Series Vol.
16
Series Title
Molecular pathology library
ISBN
9783319680941
9783319680934 (print ed.)
9783319680958 (print ed.)
9783319885476 (print ed.)
ISSN
1935-987X
Subjects (MeSH)
Hodgkin Disease - physiopathology
Hodgkin Disease - therapy
Molecular Diagnostic Techniques
Molecular Targeted Therapy
Pathology, Molecular - methods
Precision Medicine - methods
Specialty
Medical Oncology
Molecular Medicine
Pathology
Precision Medicine
Abstract
This text provides a comprehensive and up-to-date overview of Hodgkin lymphoma. The volume reviews every facet of the cancer in great detail, including pathology, pathobiology, molecular genetics, microenvironment, epidemiology, treatment, and new therapeutic advances. The specific role of the lymphoma microenvironment is addressed, and the relationship of Hodgkin lymphoma to related non-Hodgkin lymphomas is covered as well. Written by experts in the field, Precision Molecular Pathology of Hodgkin Lymphoma is a valuable resource for oncologists, surgeons, pathologists, clinical trainees, and investigators engaged in the diagnosis, treatment, and research studies of this lymphoid neoplasm.
Contents
1. Clinical Features of Hodgkin Lymphoma -- 2. Pathology of Hodgkin Lymphoma -- 3. Pathogenesis and Molecular Genetics of Hodgkin Lymphoma -- 4. Targeting the Microenvironment in Hodgkin Lymphoma: Opportunities and Challenges -- 5. Role of EBV in Classical Hodgkin Lymphoma -- 6. Pathobiology of Nodular Lymphocyte Predominant Hodgkin Lymphoma -- 7. Composite Lymphomas and the Relationship of Hodgkin Lymphoma to Non-Hodgkin Lymphomas -- 8. The Epidemiology of Hodgkin Lymphoma -- 9. Treatment and Prognosis -- 10. Novel Targeted Therapies in Hodgkin Lymphoma.
Format
e-Book
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Online
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Precision Molecular Pathology of Liver Cancer

https://libcat.nshealth.ca/en/permalink/provcat43315
Chen Liu, editor. --Cham: Springer , c2018.
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This volume provides the most updated knowledge on the advancement of molecular pathogenesis, molecular diagnosis, and therapy development for hepatocellular carcinoma (HCC). Topics covered include the etiology and pathogenesis of HCC, recent advances in HCC genomics, biomarker discovery and validation in HCC diagnosis, the role of liver biopsy in HCC early diagnosis, and the future prospects of surgical approaches and targeted therapy for HCC. In addition to reviewing the current available kno…
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Other Authors
Liu, Chen
Responsibility
Chen Liu, editor
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2018
Physical Description
1 online resource (xi, 271 p.) : 30 illus., 22 illus. in color
Series Vol.
14
Series Title
Molecular pathology library
ISBN
9783319680828
9783319680804 (print ed.)
9783319680811 (print ed.)
9783319885438 (print ed.)
ISSN
1935-987X
Subjects (MeSH)
Carcinoma, Hepatocellular - pathology
Carcinoma, Hepatocellular - therapy
Molecular Diagnostic Techniques
Molecular Targeted Therapy
Pathology, Molecular - methods
Precision Medicine - methods
Specialty
Gastroenterology
Medical Oncology
Molecular Medicine
Pathology
Precision Medicine
Abstract
This volume provides the most updated knowledge on the advancement of molecular pathogenesis, molecular diagnosis, and therapy development for hepatocellular carcinoma (HCC). Topics covered include the etiology and pathogenesis of HCC, recent advances in HCC genomics, biomarker discovery and validation in HCC diagnosis, the role of liver biopsy in HCC early diagnosis, and the future prospects of surgical approaches and targeted therapy for HCC. In addition to reviewing the current available knowledge, the book also discusses the future development of a precision and personalized medicine approach for HCC. Written by experts in the field, Precision Molecular Pathology of Liver Cancer is a concise yet comprehensive resource for practitioners who treat patients with hepatocellular carcinoma.
Contents
1. Etiology and Pathogenesis of Hepatocellular Carcinoma -- 2. Histologic Classification of Hepatocellular Carcinoma and Its Clinical Implications -- 3. Molecular Classification of Hepatocellular Carcinoma and Precision Medicine -- 4. Genomics Studies in Hepatocellular Carcinoma via Next-Generation Sequencing -- 5. Epigenetic Regulations in the Pathogenesis of HCC and the Clinical Application -- 6. Biomarker Discovery and Validation in HCC Diagnosis, Prognosis, and Therapy -- 7. Imaging of Hepatocellular Carcinoma -- 8. Epithelial-to-Mesenchymal Transition in Hepatocellular Carcinoma -- 9. Hepatocellular Carcinoma Metastasis and Circulating Tumor Cells -- 10. Immune Regulation in HCC and the Prospect of Immunotherapy -- 11. Liver Cell Dysplasia and the Development of HCC -- 12. Locoregional Therapies for Hepatocellular Carcinoma -- 13. The Future Prospect of Targeted Therapy in Hepatocellular Carcinoma.
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e-Book
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Online
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Precision Molecular Pathology of Lung Cancer

https://libcat.nshealth.ca/en/permalink/provcat43227
Philip T. Cagle, Timothy Craig Allen, Mary Beth Beasley, Lucian R. Chirieac, Sanja Dacic, Alain C. Borczuk, Keith M. Kerr, Lynette M. Sholl, Bryce Portier, Eric H. Bernicker, editors. (Second edition) --Cham: Springer , c2018.
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This new edition provides the latest information and insights into the molecular basis for lung cancer. Since the publication of the previous edition of this volume, dramatic changes have occurred with the classification of lung cancer, biomarker testing, and molecular therapy. The book covers these changes, providing updates and new insights on the background of lung cancer, testing methods, and the molecular pathology of specific cell types, including adenocarcinoma, squamous cell carcinoma, …
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Other Authors
Cagle, Philip T.
Responsibility
Philip T. Cagle, Timothy Craig Allen, Mary Beth Beasley, Lucian R. Chirieac, Sanja Dacic, Alain C. Borczuk, Keith M. Kerr, Lynette M. Sholl, Bryce Portier, Eric H. Bernicker, editors
Edition
Second edition
Former Title
Molecular pathology of lung cancer
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2018
Physical Description
1 online resource (viii, 296 p.) : 57 illus., 55 illus. in color
Series Vol.
13
Series Title
Molecular pathology library
ISBN
9783319629414
9783319629407 (print ed.)
9783319629421 (print ed.)
9783319874340 (print ed.)
ISSN
1935-987X
Subjects (MeSH)
Lung Neoplasms - pathology
Molecular Diagnostic Techniques
Molecular Targeted Therapy
Pathology, Molecular - methods
Precision Medicine - methods
Specialty
Medical Oncology
Molecular Medicine
Pathology
Pulmonary Medicine
Precision Medicine
Notes
Preceded by: Molecular pathology of lung cancer / Philip T. Cagle ... [et al.], editors. c2012.
Abstract
This new edition provides the latest information and insights into the molecular basis for lung cancer. Since the publication of the previous edition of this volume, dramatic changes have occurred with the classification of lung cancer, biomarker testing, and molecular therapy. The book covers these changes, providing updates and new insights on the background of lung cancer, testing methods, and the molecular pathology of specific cell types, including adenocarcinoma, squamous cell carcinoma, small cell carcinoma, and precursor and preinvasive lesions. Authored by experts in the field, Precision Molecular Pathology of Lung Cancer, Second Edition remains one of the few books that comprehensively covers the new molecular pathology of lung cancer and is a valuable resource for pathologists, medical oncologists, radiation oncologists, thoracic surgeons, and thoracic radiologists.
Contents
Part I. Background -- 1. Precision Medicine of Lung Cancer: Introduction -- 2. Lung Cancer Epidemiology and Demographics -- 3. Genetic Susceptibility to Lung Cancer -- 4. Lung Cancer Stem Cells -- 5. The 2015 World Health Organization Classification of Lung Cancer: Overview -- Part II. Testing Methods -- 6. Preanalytic Considerations -- 7. Mutation Testing of Lung Cancer Biomarkers -- 8. Translocation Testing of Lung Cancer Biomarkers -- 9. Immunohistochemistry of Lung Cancer Biomarkers -- 10. Next Generation and Third Generation Sequencing of lung cancer biomarkers -- Part III. Molecular Pathology of Specific Cell Types -- 11. Mutations as Predictive Biomarkers for Adenocarcinoma -- 12. Translocations as Predictive Biomarkers for Adenocarcinoma -- 13. Predictive Biomarkers for Squamous Cell Carcinoma -- 14. Molecular Pathology of Small Cell Carcinoma -- 15. Molecular Pathology of Uncommon Carcinomas -- 16. Molecular Pathology of Lung Cancer Metastases -- 17. Molecular Pathology of Precursor and Preinvasive Lesions -- Part IV. General and Emerging Fields in Molecular Pathology of Lung Cancer -- 18. Prognostic Biomarkers in Lung Cancer -- 19. Biomarkers and Differing Therapy Modalities -- 20. Immuno-oncology of Lung Cancer -- 21. Liquid Biopsy.
Format
e-Book
Location
Online
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Precision Molecular Pathology of Myeloid Neoplasms

https://libcat.nshealth.ca/en/permalink/provcat43385
Chung-Che (Jeff) Chang, Robert S. Ohgami, editors. --Cham: Springer , c2018.
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This volume provides a comprehensive, state-of-the art review of myeloid neoplasms. The book presents updated information on epidemiology, clinical presentation, morphologic findings, molecular genomic abnormalities, pathogenesis, and target therapies. The text helps to guide accurate diagnosis, the administration of appropriate ancillary molecular tests, patient management, and investigative efforts. Written by experts in the field, Precision Molecular Pathology of Myeloid Neoplasms serves as …
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Other Authors
Chang, Chung-Che (Jeff)
Ohgami, Robert S.
Responsibility
Chung-Che (Jeff) Chang, Robert S. Ohgami, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2018
Physical Description
1 online resource (xi, 427 p.) : 84 illus., 66 illus. in color
Series Vol.
12
Series Title
Molecular pathology library
ISBN
9783319621463
9783319621449 (print ed.)
9783319621456 (print ed.)
9783319872414 (print ed.)
ISSN
1935-987X
Subjects (MeSH)
Bone Marrow Neoplasms - pathology
Leukemia, Myeloid - pathology
Molecular Diagnostic Techniques
Molecular Targeted Therapy
Pathology, Molecular - methods
Precision Medicine - methods
Specialty
Hematology
Medical Oncology
Molecular Medicine
Pathology
Precision Medicine
Abstract
This volume provides a comprehensive, state-of-the art review of myeloid neoplasms. The book presents updated information on epidemiology, clinical presentation, morphologic findings, molecular genomic abnormalities, pathogenesis, and target therapies. The text helps to guide accurate diagnosis, the administration of appropriate ancillary molecular tests, patient management, and investigative efforts. Written by experts in the field, Precision Molecular Pathology of Myeloid Neoplasms serves as a valuable resource for pathologists, hematologists/oncologists, fellows, and researchers in understanding the molecular pathology of myeloid neoplasms.
Contents
1. Acute Myeloid Leukemia with Recurrent Genetic Abnormalities, Part I: Cytogenetic Abnormalities -- 2. Acute Myeloid Leukemia with Recurrent Genetic Abnormalities, Part II: Mutations Involving CEBPA, NPM1, and RUNX1 -- 3. Acute Myeloid Leukemia with Myelodysplasia-Related Changes, Therapy-Related Myeloid Neoplasms, and Acute Myeloid Leukemia, Not Otherwise Specified -- 4. Myelodysplastic Syndrome -- 5. Chronic Myeloid Leukemia, BCR-ABL1 Positive -- 6. Updates in Polycythemia Vera -- 7. Essential Thrombocythemia -- 8. Primary Myelofibrosis -- 9. Mastocytosis -- 10. Chronic Myeloproliferative Neoplasm, Rare Types -- 11. Atypical Chronic Myeloid Leukemia, BCR/ABL1 Negative -- 12. Chronic Myelomonocytic Leukemia: Clinical and Pathologic Features -- 13. Juvenile Myelomonocytic Leukemia -- 14. Down Syndrome-Associated Hematologic Disorders and Leukemia -- 15. Inherited and Acquired Myeloid Neoplasms of Childhood -- 16. Myeloid and Lymphoid Neoplasms with Eosinophilia and Abnormalities of PDGFRA, PDGFRB, FGFR1, or t(8;9)(p22;p24.1);PCM1-JAK2 -- 17. Mixed Phenotype Acute Leukemia -- 18. Blastic Plasmacytoid Dendritic Cell Neoplasm -- 19. Existing and Emerging Molecular Technologies in Myeloid Neoplasms.
Format
e-Book
Location
Online
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Precision Molecular Pathology of Neoplastic Pediatric Diseases

https://libcat.nshealth.ca/en/permalink/provcat42616
Larissa V. Furtado, Aliya N. Husain, editors. --Cham: Springer , c2018.
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This book provides a comprehensive, state-of-the art review of pediatric oncology. The text covers relevant concepts in molecular biology and addresses technical principles, applications, challenges, and integration of current and emerging genomic and molecular methods in the diagnosis and personalized management of childhood cancers. The text also discusses a wide array of pediatric neoplasms in the context of molecular pathology in a concise and understandable manner, with focus on their mole…
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Other Authors
Furtado, Larissa V.
Husain, Aliya N.
Responsibility
Larissa V. Furtado, Aliya N. Husain, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2018
Physical Description
1 online resource (viii, 360 p.) : 64 illus., 63 illus. in color
Series Title
Molecular pathology library
ISBN
9783319896267
9783319896250 (print ed.)
9783319896274 (print ed.)
ISSN
1935-987X
Subjects (MeSH)
Child
Neoplasms - pathology
Pathology, Molecular - methods
Precision Medicine - methods
Specialty
Medical Oncology
Molecular Medicine
Pathology
Pediatrics
Precision Medicine
Abstract
This book provides a comprehensive, state-of-the art review of pediatric oncology. The text covers relevant concepts in molecular biology and addresses technical principles, applications, challenges, and integration of current and emerging genomic and molecular methods in the diagnosis and personalized management of childhood cancers. The text also discusses a wide array of pediatric neoplasms in the context of molecular pathology in a concise and understandable manner, with focus on their molecular pathogenesis, clinicopathological features, classification, molecular diagnosis, and approaches to personalized care. Written by experts in the field, Precision Molecular Pathology of Neoplastic Pediatric Diseases serves as a valuable resource for pathologists, pediatric oncologists, trainees and researchers with an interest in pediatric and molecular pathology.
Contents
Part I. Molecular Pathology of Pediatric Neoplasms: General Principles -- 1. Principles of Molecular Biology and Oncogenesis -- 2. Molecular Methods in Oncology: Targeted Mutational Analysis -- 3. Molecular Methods in Oncology: Genomic Analysis -- 4. Molecular Testing in Pediatric Oncology Practice -- 5. Molecular Targeted Therapy of Pediatric Neoplasms -- Part II. Molecular Pathology of Specific Pediatric Neoplasms -- 6. Hematolymphoid System -- 7. Pediatric Brain Tumors -- 8. Neuroblastoma and Neuroblastic Tumors -- 9. Soft Tissue and Bone Neoplasms -- 10. Skin, Melanocytic Neoplasms -- 11. Salivary Gland, Thyroid, and Parathyroid Neoplasms: Molecular Features -- 12. Cardiovascular and Respiratory Systems -- 13. Gastrointestinal Tract -- 14. Liver and Pancreas -- 15. Molecular Pathology of Pediatric Renal Tumors.
Format
e-Book
Location
Online
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Precision Molecular Pathology of Prostate Cancer

https://libcat.nshealth.ca/en/permalink/provcat42811
Brian D. Robinson, Juan Miguel Mosquera, Jae Y. Ro, Mukul Divatia, editors. --Cham: Springer , c2018.
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This volume focuses on our current understanding of the molecular underpinnings of prostate cancer and their potential application for precision medicine approaches. The emergence and applications of new technologies has allowed for a rapid expansion of our understanding of the molecular basis of prostate cancer and has revealed a remarkable genetic heterogeneity that may underlie the clinically variable behavior of the disease. The book consists of five sections which provide insight about the…
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Other Authors
Robinson, Brian D.
Mosquera, Juan Miguel
Ro, Jae Y.
Divatia, Mukul
Responsibility
Brian D. Robinson, Juan Miguel Mosquera, Jae Y. Ro, Mukul Divatia, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2018
Physical Description
1 online resource (xiv, 570 p.) : 50 illus., 48 illus. in color
Series Title
Molecular pathology library
ISBN
9783319640969
9783319640945 (print ed.)
9783319640952 (print ed.)
9783319877211 (print ed.)
ISSN
1935-987X
Subjects (MeSH)
Precision Medicine
Prostatic Neoplasms - genetics
Prostatic Neoplasms - pathology
Specialty
Medical Oncology
Molecular Medicine
Pathology
Precision Medicine
Urology
Abstract
This volume focuses on our current understanding of the molecular underpinnings of prostate cancer and their potential application for precision medicine approaches. The emergence and applications of new technologies has allowed for a rapid expansion of our understanding of the molecular basis of prostate cancer and has revealed a remarkable genetic heterogeneity that may underlie the clinically variable behavior of the disease. The book consists of five sections which provide insight about the following: (1) General principles; (2) Molecular signatures of primary prostate cancer; (3) Molecular signatures of advanced prostate cancer; (4) Key molecular pathways in prostate cancer development and progression; (5) Precision medicine approach: Diagnosis, treatment, prognosis. Precision Molecular Pathology of Prostate Cancer is an important resource for the practicing oncologist, urologist, and pathologist, and will also be useful for researchers in the prostate cancer community.
Contents
Part I. General Principles -- 1. Precision Medicine in Prostate Cancer: Approach to the Patient -- 2. Epidemiology and Etiology -- 3. High-Grade Prostatic Intraepithelial Neoplasia -- 4. Pathology of Prostate Cancer -- 5. Genetic Susceptibility -- 6. Racial Differences -- 7. Cancer Stem Cells -- Part II. Molecular Signatures of Primary Prostate Cancer -- 8. Prostate Cancer Risk: Single Nucleotide Polymorphisms (SNPs) -- 9. Copy Number Variation/Chromosomal Aberration -- 10. Gene Fusions -- 11. Gene Expression Analysis -- 12. Next-Generation Sequencing -- 13. Epigenetic Alterations in Primary Prostate Cancer -- 14. Proteomics in Prostate Cancer Research -- 15. Metabolomic-Based Stratification in Prostate Cancer -- 16. Tumor Microenvironment: Prospects for Diagnosis and Prognosis of Prostate Cancer Based on Changes in Tumor-Adjacent Stroma -- Part III. Molecular Signatures of Advanced Prostate Cancer -- 17. Metastatic Prostate Cancer -- 18. Castration-Resistant Prostate Cancer -- 19. Neuroendocrine Prostate Cancer -- Part IV. Key Molecular Pathways in Prostate Cancer Development and Progression -- 20. The Role of Androgen Receptor in Prostate Cancer -- 21. PI3K/Akt/mTOR/PTEN and ERK/MAPK Pathways -- 22. The Cell Cycle and Androgen Signaling Interactions in Prostate Cancer -- 23. DNA Damage Repair -- 24. Tyrosine Kinase Receptor Signaling in Prostate Cancer -- 25. Microtubules in Prostate Cancer -- Part V. Precision Medicine Approach: Diagnosis, Treatment, Prognosis -- 26. Prostate Cancer Tissue Diagnosis -- 27. Molecular Imaging of Prostate Cancer: Radiopharmaceuticals for Positron Emission Tomography (PET) and Single-Photon Emission Computed Tomography (SPECT) -- 28. Prostate Cancer Molecular Prognosis -- 29. Molecular Targeted Therapies of Prostate Cancer -- 30. Overview of Prostate Cancer Molecular Classification.
Format
e-Book
Location
Online
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Precision Molecular Pathology of Uterine Cancer

https://libcat.nshealth.ca/en/permalink/provcat41829
Michael T. Deavers, Donna M. Coffey, editors. --Cham: Springer , 2017.
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This text provides a comprehensive review for practicing pathologists to understand the molecular biology, diagnostics, and predictive markers and implications for therapy of uterine cancer. While molecular based therapeutic strategies for uterine cancer are not as well developed as for some other organ sites, these are the most common gynecologic malignancies and there have been many important recent developments that are discussed in this volume. Comprehensive chapters address essential infor…
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Other Authors
Deavers, Michael T
Coffey, Donna M
Responsibility
Michael T. Deavers, Donna M. Coffey, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
2017
Physical Description
1 online resource (ix, 286 pages) : 48 illus., 47 illus. in color
Series Vol.
11
Series Title
Molecular pathology library
ISBN
9783319579856
9783319579832 (print ed.)
ISSN
1935-987X
Subjects (MeSH)
Molecular Medicine
Uterine Neoplasms - etiology
Uterine Neoplasms - pathology
Abstract
This text provides a comprehensive review for practicing pathologists to understand the molecular biology, diagnostics, and predictive markers and implications for therapy of uterine cancer. While molecular based therapeutic strategies for uterine cancer are not as well developed as for some other organ sites, these are the most common gynecologic malignancies and there have been many important recent developments that are discussed in this volume. Comprehensive chapters address essential information about endometrial carcinoma, uterine mesenchymal tumors, and cervical carcinoma and include the pathogenesis of carcinoma and discuss molecular based classification, biomarkers, therapy, prevention, and hereditary cancers of the uterus. Precision Molecular Pathology of Uterine Cancer is a unique and one of a kind resource for practicing pathologists, pathologists in training and gynecologists.
Contents
Part I: Introduction -- Endometrial Carcinoma: Precursor Lesions and Molecular Profiles -- Part II: Endometrial Carcinoma -- Classification of Endometrial Carcinoma -- Immunohistochemical Markers in Endometrial Carcinoma -- Molecular Pathology of Endometrioid Adencarcinoma -- The Molecular Pathology of Serous Endometrial Cancer -- Uterine Clear Cell Carcinoma -- Mucinous Adenocarcinoma of the Endometrium -- Molecular Pathology of Uterine Carcinosarcoma -- Hereditary Endometrial Carcinomas -- Targeted Therapy and Prevention of Endometrial Cancer -- Part III: Uterine Mesenchymal Tumors (Nucci) -- Molecular Pathology of Cervival Dysplasia and Carcinoma.
Format
e-Book
Location
Online
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