series:"Ophthalmology research" found 7 records - Provincial Hospitals Library Catalogue

An exciting contribution to the field, Visual Dysfunction in Diabetes: The Science of Patient Impairment and Improvement is designed with two overriding objectives: to help readers understand the impact of vision impairment in people living daily with diabetes rather than considering diabetic retinopathy solely as a medical problem, and to explore what we know and don't know about the ways diabetes affect the eye. With the plethora of new information being generated, there are still a series of…

Available Online: View e-Book

Other Authors: Tombran-Tink, Joyce; Barnstable, Colin J; Gardner, Thomas W

Responsibility: edited by Joyce Tombran-Tink, Colin J. Barnstable, Thomas W. Gardner

Place of Publication: New York, NY

Publisher: Springer

Date of Publication: c2012

Physical Description: 1 online resource (xv, 379 p. : 72 ill., 51 ill. in color)

Series Title: Ophthalmology research

ISBN: 9781607611509

Subjects (MeSH): Diabetes Complications; Diabetic Retinopathy

Subjects (LCSH): Neurosciences; Endocrinology; Ophthalmology

Abstract: An exciting contribution to the field, Visual Dysfunction in Diabetes: The Science of Patient Impairment and Improvement is designed with two overriding objectives: to help readers understand the impact of vision impairment in people living daily with diabetes rather than considering diabetic retinopathy solely as a medical problem, and to explore what we know and don't know about the ways diabetes affect the eye. With the plethora of new information being generated, there are still a series of fundamental questions that must be addressed if effective treatments for diabetic retinopathy are to be found and applied. Developed by a renowned group of authorities, Visual Dysfunction in Diabetes: The Science of Patient Impairment and Improvement offers responses and context for a range of questions, such as: do metabolic factors beyond glucose contribute to vision-threatening diabetic retinopathy? If so, how do these lead to vision impairment? Is diabetic retinopathy a response to systemic metabolic abnormalities or are there unique ocular problems related to insulin resistance? What is the relationship between the neural, vascular, and inflammatory abnormalities in diabetic retinopathy? Do they represent a pathological cascade induced sequentially or simultaneous responses to one or more metabolic perturbations? The authors note that if we do not address these types of questions, it is possible that the long process of developing new therapeutics will target only one arm of the pathology and leave the retina open to damaging consequences of the others. State-of-the-art, comprehensive, and an invaluable addition the research and clinical literature, Visual Dysfunction in Diabetes: The Science of Patient Impairment and Improvement offers guidance and a significant step toward new scientific approaches that can lessen the devastating vision impairment associated with diabetes.

Contents: Pt. I. Living with diabetic retinopathy -- Living with diabetic retinopathy : the patient's view -- Pt. II. How is diabetic retinopathy detected? -- Diabetic retinopathy screening : progress or lack of progress -- Functional/neural mapping discoveries in the diabetic retina : advancing clinical care with the multifocal ERG -- Pt. III. How does diabetes affect the eye? -- Corneal diabetic neuropathy -- Clinical phenotypes of diabetic retinopathy -- Visual psychophysics in diabetic retinopathy -- Mechanisms of blood-retinal barrier breakdown -- Molecular regulation of endothelial cell tight junctions and the blood-retinal barrier -- Capillary degeneration in diabetic retinopathy -- Proteases in diabetic retinopathy -- Proteomics in the vitreous of diabetic retinopathy patients -- Neurodegeneration in diabetic retinopathy -- Glucose-induced cellular signaling in diabetic retinopathy -- IGFBP-3 as a regulator of the growth-hormone/insulin-like growth factor pathway in proliferative retinopathies -- Neurotrophic factors in diabetic retinopathy -- Role of CTGF in diabetic retinopathy -- Pt. IV. How can vision loss be limited : experimental therapies -- Ranidizumab and other VEGF antagonists for diabetic macular edema -- Neurodegeneration, neuropeptides, and diabetic retinopathy -- Glial cell-derived cytokines and vascular integrity in diabetic retinopathy -- Impact of islet cell transplantation on diabetic retinopathy in type 1 diabetes.