Antibiotics as Anti-Inflammatory and Immunomodulatory Agents
https://libcat.nshealth.ca/en/permalink/provcat29686
edited by Bruce K. Rubin, Jun Tamaoki.
--Basel:
Birkhäuser Verlag
, c2005.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Author
- Rubin, Bruce K
- Other Authors
- Tamaoki, Jun
- Responsibility
- edited by Bruce K. Rubin, Jun Tamaoki
- Place of Publication
- Basel
- Publisher
- Birkhäuser Verlag
- Date of Publication
- c2005
- Series Title
- Progress in inflammation research
- ISBN
- 9783764373108
- Subjects (MeSH)
- Anti-Bacterial Agents - therapeutic use
- Anti-Inflammatory Agents - therapeutic use
- Immunomodulation
- Subjects (LCSH)
- Pharmacy
- Immunology
- Format
- e-Book
- Location
- Online
Antimicrobial peptides and innate immunity
https://libcat.nshealth.ca/en/permalink/provcat32483
Pieter S. Hiemstra, Sebastian A. J. Zaat, editors.
--Basel:
Springer
, c2013.
- Available Online
- View e-Book
- Location
- Online
Antimicrobial peptides have been the subject of intense research in the past decades, and are now considered as an essential part of the defense system in bacteria, plants, animals and humans. This book provides an update on these effector molecules of the innate immune system both for researchers who are already actively involved in the area, and for those with a general interest in the topic. The book starts with an overview of the evolution of cysteine-containing antimicrobial peptides (inc…
- Available Online
- View e-Book
- Other Authors
- Hiemstra, Pieter S
- Zaat, Sebastian A. J
- Responsibility
- Pieter S. Hiemstra, Sebastian A. J. Zaat, editors
- Place of Publication
- Basel
- Publisher
- Springer
- Date of Publication
- c2013
- Physical Description
- 1 online resource (xi, 384 p. : 38 ill., 23 ill. in color)
- Series Title
- Progress in inflammation research
- ISBN
- 9783034805414
- Subjects (LCSH)
- Immunology
- Microbiology
- Infectious diseases
- Biochemistry
- Abstract
- Antimicrobial peptides have been the subject of intense research in the past decades, and are now considered as an essential part of the defense system in bacteria, plants, animals and humans. This book provides an update on these effector molecules of the innate immune system both for researchers who are already actively involved in the area, and for those with a general interest in the topic. The book starts with an overview of the evolution of cysteine-containing antimicrobial peptides (including defensins), and the role of these peptides in host defense in plants and micro-organisms. The realization that antimicrobial peptides also display functions distinct from their direct antimicrobial action is the focus of the next chapters, and puts these peptides center stage in immunity and wound repair. Further chapters discuss the role of antimicrobial peptides in disease, by providing an overview of mechanisms in bacterial resistance to antimicrobial peptides and a discussion of their role in inflammatory bowel disease, cystic fibrosis lung disease and chronic obstructive pulmonary disease. Finally, the book shows how knowledge of the function of antimicrobial peptides and their regulation can be used to design new therapies for inflammatory and infectious disorders. This is a very important area of research because of the increase in resistance of micro-organisms to conventional antibiotics. Therefore the use of synthetic or recombinant peptides, or agents that stimulate the endogenous production of antimicrobial peptides, provides an attractive alternative for conventional antibiotics.
- Contents
- Evolution of Antimicrobial Peptides: a View From the Cystine Chapel -- Innate immunity in plants: the role of antimicrobial peptides -- Antimicrobial peptides produced by microorganisms -- LL-37: an immunomodulatory antimicrobial host defence peptide -- Wound Repair and Antimicrobial Peptides -- WAPing out pathogens and disease in the mucosa-roles for SLPI and trappin-2 -- Histatins: multifunctional salivary antimicrobial peptides -- Structure-function relationships of antimicrobial chemokines -- Mechanisms and Significance of Bacterial Resistance to Human Cationic Antimicrobial Peptides -- Antimicrobial peptides and inflammatory bowel disease -- Cystic Fibrosis and Defective Airway Innate Immunity -- Antimicrobial peptides in chronic obstructive pulmonary disease -- Host defense peptides: Immune modulation and antimicrobial activity in vivo -- Helping the host induction of antimicrobial peptides as a novel therapeutic strategy against infections.
- Format
- e-Book
- Location
- Online
Antirheumatic Therapy : Actions and Outcomes
https://libcat.nshealth.ca/en/permalink/provcat30483
edited by Richard O. Day, Daniel E. Fürst, Piet L. C. M. Riel, Barry Bresnihan.
--Basel:
Birkhäuser Verlag
, c2005.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Author
- Day, Richard O
- Other Authors
- Fürst, Daniel E
- Riel, Piet L. C. M
- Bresnihan, Barry
- Responsibility
- edited by Richard O. Day, Daniel E. Fürst, Piet L. C. M. Riel, Barry Bresnihan
- Place of Publication
- Basel
- Publisher
- Birkhäuser Verlag
- Date of Publication
- c2005
- Series Title
- Progress in inflammation research
- ISBN
- 9783764377267
- Subjects (MeSH)
- Antirheumatic Agents
- Arthritis, Rheumatoid - drug therapy
- Subjects (LCSH)
- Rheumatology
- Pharmacy
- Format
- e-Book
- Location
- Online
Autophagy Networks in Inflammation
https://libcat.nshealth.ca/en/permalink/provcat40154
Maria Chiara Maiuri, Daniela De Stefano, editors.
--Cham:
Springer
, c2016.
- Available Online
- View e-Book
- Location
- Online
Autophagy principally serves an adaptive function to protect organisms against diverse human pathologies, including cancer and neurodegeneration. Recent developments using in vitro, ex vivo and in vivo models show the involvement of the autophagy pathway in immunity and inflammation. Moreover, direct interactions between autophagy proteins and immune signalling molecules have also been demonstrated. Defects in autophagy - similar to cancer, neurodegenerative diseases and aging - through autopha…
- Available Online
- View e-Book
- Other Authors
- Maiuri, Maria Chiara
- De Stefano, Daniela
- Responsibility
- Maria Chiara Maiuri, Daniela De Stefano, editors
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2016
- Physical Description
- 1 online resource (xv, 403 p. : 20 illus., 16 illus. in color)
- Series Title
- Progress in inflammation research
- ISBN
- 9783319300795
- 9783319300771 (print ed.)
- Subjects (MeSH)
- Autophagy
- Inflammasomes
- Inflammation - physiopathology
- Inflammation - therapy
- Abstract
- Autophagy principally serves an adaptive function to protect organisms against diverse human pathologies, including cancer and neurodegeneration. Recent developments using in vitro, ex vivo and in vivo models show the involvement of the autophagy pathway in immunity and inflammation. Moreover, direct interactions between autophagy proteins and immune signalling molecules have also been demonstrated. Defects in autophagy - similar to cancer, neurodegenerative diseases and aging - through autophagy gene mutation and/or microbial antagonism, may underlie the pathogenesis of many infectious diseases and inflammatory syndromes. In spite of the increasing awareness of the importance of autophagy in these pathophysiological conditions, this process remains underestimated and is often overlooked. As a consequence, its role in the initiation, stability, maintenance, and progression of these diseases are still poorly understood. This book reviews the recent advances regarding the functions of the autophagy pathway and autophagy proteins in immunity and inflammation, focusing on their role in self-nonself distinction, their implications in innate and adaptive immune responses and their dysregulation in the pathology of certain inflammatory and autoimmune diseases.
- Contents
- [publisher supplied] Autophagy in direct pathogen elimination (Xenophagy) -- Autophagy and pattern recognition receptors -- Autophagy and inflammasomes -- Autophagy and Antigen presentation -- Autophagy and regulation of T and B cell function -- Autophagy in chronic inflammation -- The complex crosstalk between autophagy and ROS -- Lipophagy -- Autophagy, phagocytosis and entosis: who eats whom? -- Which is the cell fate of inflammatory cells? Autophagic cell death, pyroptosis, netosis, apoptosis, necrosis -- Host defence (virus/bacteria) -- Neurological diseases -- Pulmonary diseases (emphysema, COPD, etc.) -- Inflammatory bowel disease -- Target autophagy as a novel therapeutic strategy in autoimmune diseases -- Liver and pancreatic diseases -- Obesity -- Aging -- Overview on clinical trials.
- Format
- e-Book
- Location
- Online
The Blood Brain Barrier and Inflammation
https://libcat.nshealth.ca/en/permalink/provcat41542
Ruth Lyck, Gaby Enzmann, editors.
--Cham:
Springer
, 2017.
- Available Online
- View e-Book
- Location
- Online
Within the central nervous system (CNS) the constantly changing blood stream is separated from the CNS parenchyma by the blood brain barrier (BBB) restricting passage to selected immune cells. Under pathological conditions, however, viruses, bacteria, parasites and autoaggressive immune cells can penetrate the barrier and contribute to CNS inflammation. The BBB actively contributes to neuroinflammation by presentation of chemokines, expression of cell adhesion molecules and alteration of barrie…
- Available Online
- View e-Book
- Other Authors
- Lyck, Ruth
- Enzmann, Gaby
- Responsibility
- Ruth Lyck, Gaby Enzmann, editors
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- 2017
- Physical Description
- 1 online resource (vi, 286 pages) : 32 illus., 24 illus. in color
- Series Title
- Progress in inflammation research
- ISBN
- 9783319455143
- 9783319455129 (print ed.)
- Subjects (MeSH)
- Blood-Brain Barrier - physiopathology
- Central Nervous System Diseases - metabolism
- Models, Animal
- Neurogenic Inflammation - metabolism
- Abstract
- Within the central nervous system (CNS) the constantly changing blood stream is separated from the CNS parenchyma by the blood brain barrier (BBB) restricting passage to selected immune cells. Under pathological conditions, however, viruses, bacteria, parasites and autoaggressive immune cells can penetrate the barrier and contribute to CNS inflammation. The BBB actively contributes to neuroinflammation by presentation of chemokines, expression of cell adhesion molecules and alteration of barrier properties. As such, understanding the role of the BBB under healthy and pathological conditions is essential for the development of new drugs to efficiently combat inflammatory diseases of the CNS. This book presents a comprehensive collection of reviews that focus on the role of the BBB. Experts in the field share their insight on structural, topological and functional properties of the BBB. They elaborate on pathophysiological changes of the inflamed BBB such as permeability, transporter proteins and alterations in microRNAs and cytokine profile. Additional chapters on multiple sclerosis and bacterial meningitis provide in depth information on significant neuroinflammatory diseases. The selection is complemented by a review on the current understanding of the BBB as signaling hub in tumor pathogenesis in the brain.
- Contents
- General Introduction to Barrier Mechanisms in the Central Nervous System -- Topological Aspects of the Blood-Brain and Blood-Cerebrospinal Fluid Barriers and their Relevance in Inflammation Research -- The Contribution of the Extracellular Matrix to the BBB in Steady State and Inflammatory Conditions -- Pathophysiology of the Bloodbrain Barrier in Neuroinflammatory Diseases -- Leakage at Blood-neural Barriers -- Blood-Brain Barrier Transporters and Neuroinflammation: Partners in Neuroprotection and in Pathology -- MicroRNAs in Brain Endothelium and Inflammation -- Blood-Brain Barrier Dysfunction during Central Nervous System Autoimmune Diseases -- Pathways Across the Blood Brain Barrier -- Neuroinflammation in Bacterial Meningitis -- Blood Vessels in the Brain: a Signaling Hub in Brain Tumor Inflammation.
- Format
- e-Book
- Location
- Online
Bone Morphogenetic Proteins : From Local to Systemic Therapeutics
https://libcat.nshealth.ca/en/permalink/provcat41044
Slobodan Vukicevic, Kuber T. Sampath, editors.
--Basel:
Birkhäuser Verlag
, c2008.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Other Authors
- Vukicevic, Slobodan, 1951-
- Sampath, Kuber T
- Responsibility
- Slobodan Vukicevic, Kuber T. Sampath, editors
- Place of Publication
- Basel
- Publisher
- Birkhäuser Verlag
- Date of Publication
- c2008
- Physical Description
- 1 online resource (xi, 343 p.) : ill. (some col.)
- Series Title
- Progress in inflammation research
- ISBN
- 9783764385521
- 9783764385514 (print ed.)
- Subjects (MeSH)
- Bone Morphogenetic Proteins - physiology
- Bone Morphogenetic Proteins - therapeutic use
- Bone Regeneration - physiology
- Format
- e-Book
- Location
- Online
Bone Morphogenetic Proteins : Systems Biology Regulators
https://libcat.nshealth.ca/en/permalink/provcat41581
Slobodan Vukicevic, Kuber T. Sampath, editors.
--Cham:
Springer
, 2017.
- Available Online
- View e-Book
- Location
- Online
This book focuses on the salient features of the biology of Bone Morphogenetic Proteins and the advances in our understanding of their structure and function and of downstream signaling, as well as their governance in systems biology from bone and dentin to kidney, cancer, diabetes, iron homeostasis and angiogenesis, including rare musculoskeletal disorders. BMPs, also referred to as growth and differentiation factors, are members of the TGF-beta superfamily and are highly conserved from fruit …
- Available Online
- View e-Book
- Other Authors
- Vukicevic, Slobodan
- Sampath, Kuber T
- Responsibility
- Slobodan Vukicevic, Kuber T. Sampath, editors
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- 2017
- Physical Description
- 1 online resource (xii, 445 pages) : 43 illus., 32 illus. in color
- Series Title
- Progress in inflammation research
- ISBN
- 9783319475073
- 9783319475059 (print ed.)
- Abstract
- This book focuses on the salient features of the biology of Bone Morphogenetic Proteins and the advances in our understanding of their structure and function and of downstream signaling, as well as their governance in systems biology from bone and dentin to kidney, cancer, diabetes, iron homeostasis and angiogenesis, including rare musculoskeletal disorders. BMPs, also referred to as growth and differentiation factors, are members of the TGF-beta superfamily and are highly conserved from fruit flies to mammals and are responsible for the formation of practically every organ during embryo development and involved in adult tissue injury and repair. BMPs establish their extracellular gradient by interacting with their respective antagonists and regulate their function through SMAD-dependent down-stream signaling effector genes. This volume is aimed at scientists and professionals dealing with metabolic disorders, nutrition, systems biology diseases, rare musculoskeletal conditions, and disorders related to iron metabolism, including anemia of chronic disease, hereditary hemochromatosis and beta thalassemia.
- Contents
- Historical Perspective of Bone Morphogenetic Proteins -- The Systems Biology of Bone Morphogenetic Proteins -- Embryonic Skeletogenesis and Craniofacial Development -- BMP and BMP Regulation: Structure and Function -- Novel In Vitro Assay Models to Study Osteogenesis and Chondrogenesis for Human Skeletal Disorders -- Toward Advanced Therapy Medicinal Products (ATMPs) Combining Bone Morphogenetic Proteins (BMP) and Cells for Bone Regeneration -- BMP Signaling in Articular Cartilage Repair and Regeneration: Potential Therapeutic Opportunity for Osteoarthritis -- BMPs in Orthopaedic Medicine: Promises and Challenges -- Osteogrow: A Novel Bone Graft Substitute for Orthopedic Reconstruction -- Biology of Spine Fusion and Application of Osteobiologics in Spine Surgery -- BMPs in Dental Medicine: Promises and Challenges -- Bone Morphogenetic Protein-7 and Its Role in Acute Kidney Injury and Chronic Kidney Failure -- Bone Morphogenetic Protein Signaling in Pulmonary Arterial Hypertension -- BMP Signaling in Fibrodysplasia Ossificans Progressiva, a Rare Genetic Disorder of Heterotopic Ossification -- The Central Role of BMP Signaling in Regulating Iron Homeostasis -- BMPs in Inflammation -- Physiological and Pathological Consequences of Vascular BMP Signaling -- Bone Morphogenetic Proteins in the Initiation and Progression of Breast Cancer.
- Format
- e-Book
- Location
- Online
Endothelial Dysfunction and Inflammation
https://libcat.nshealth.ca/en/permalink/provcat28152
edited by Shauna Dauphinee, Aly Karsan.
--Basel:
Springer Basel AG
, c2010.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Author
- Dauphinee, Shauna
- Other Authors
- Karsan, Aly
- Responsibility
- edited by Shauna Dauphinee, Aly Karsan
- Place of Publication
- Basel
- Publisher
- Springer Basel AG
- Date of Publication
- c2010
- Series Title
- Progress in inflammation research
- ISBN
- 9783034601689
- Subjects (MeSH)
- Endothelial Cells - pathology
- Endothelium, Vascular - physiopathology
- Inflammation - physiopathology
- Subjects (LCSH)
- Biochemistry
- Cytology
- Format
- e-Book
- Location
- Online
The Hereditary Basis of Rheumatic Diseases
https://libcat.nshealth.ca/en/permalink/provcat28794
edited by Rikard Holmdahl.
--Basel:
Birkhäuser Verlag
, c2006.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Author
- Holmdahl, Rikard
- Responsibility
- edited by Rikard Holmdahl
- Place of Publication
- Basel
- Publisher
- Birkhäuser Verlag
- Date of Publication
- c2006
- Series Title
- Progress in inflammation research
- ISBN
- 9783764374198
- Subjects (MeSH)
- Rheumatic Diseases - genetics
- Arthritis, Rheumatoid - genetics
- Subjects (LCSH)
- Genetics
- Rheumatology
- Format
- e-Book
- Location
- Online
IL-17, IL-22 and their producing cells : role in inflammation and autoimmunity
https://libcat.nshealth.ca/en/permalink/provcat32482
Valérie Quesniaux, Bernhard Ryffel, Franco Padova, editors.
(2nd ed.)
--Basel:
Springer
, c2013.
- Available Online
- View e-Book
- Location
- Online
The knowledge of Th17 cells and other cell populations which secrete IL-17A, and/or IL-22 has expanded tremendously since the publication of the first edition "Th17 Cells: Role in Inflammation and Autoimmune Disease" in 2008. The present volume has been completely revised with the addition of new chapters on the IL-17 receptor family and signaling, and an in-depth review of IL-22 and innate lymphoid cells. The differentiation of naive T cells into regulatory T cells and Th17 cells as well as th…
- Available Online
- View e-Book
- Other Authors
- Quesniaux, Valérie
- Ryffel, Bernhard
- Padova, Franco
- Responsibility
- Valérie Quesniaux, Bernhard Ryffel, Franco Padova, editors
- Edition
- 2nd ed.
- Place of Publication
- Basel
- Publisher
- Springer
- Date of Publication
- c2013
- Physical Description
- 1 online resource (ix, 354 p. : 25 ill., 14 ill. in color)
- Series Title
- Progress in inflammation research
- ISBN
- 9783034805223
- Subjects (MeSH)
- Immunity, Cellular - physiology
- Inflammation - physiopathology
- Interleukin-17 - immunology
- Interleukins - immunology
- Subjects (LCSH)
- Oncology
- Immunology
- Infectious diseases
- Cell receptors
- Cytokines
- Cytology
- Abstract
- The knowledge of Th17 cells and other cell populations which secrete IL-17A, and/or IL-22 has expanded tremendously since the publication of the first edition "Th17 Cells: Role in Inflammation and Autoimmune Disease" in 2008. The present volume has been completely revised with the addition of new chapters on the IL-17 receptor family and signaling, and an in-depth review of IL-22 and innate lymphoid cells. The differentiation of naive T cells into regulatory T cells and Th17 cells as well as the plasticity of Th17 cells is discussed. The role of IL-22 in cutaneous inflammation including psoriasis has been reviewed. In addition, the volume contains critical updates on autoimmunity, organ transplantation, tumor immunology and genetic mouse models for mechanistic studies. Lastly, the latest clinical progress in neutralizing antibodies to IL-17A, IL-17RA not only confirms the therapeutic promise foreseen in 2008, but also improves our knowledge of the pathogenesis of autoimmune diseases. In summary, this is a timely update and important review of the clinical and experimental aspects of IL-17, IL-22 and their producing cells.
- Contents
- IL-17A family, receptors, proinflammatory effects and production -- IL-22 and IL-17 overview -- IL-17R family: Structure, signal transduction and function -- Contribution of IL-22 to Th17 responses: repairing and protecting peripheral tissues -- Central role of Th-17 cells in adaptive immune responses -- Regulatory T cells vs Th17: Differentiation of Th17 versus Treg are they mutually exclusiveáOther sources of IL-17: iNKT cells -- Retinoic acid in mucosal immune regulation -- Critical role of IL-17 in experimental arthritis -- Dual role IL-17A, F and IL-22 in allergic asthma -- Inflammasome - IL-1 - IL-17 response in lung inflammation -- The role of Il-17 in exp autoimmune mycocarditis -- Th17 cells in transplantation: actors or innocent bystanders -- Is IL-17 required to control of tuberculosisáIL-17 and mucosal host defense. Role of IL-17 and IL-17 family cytokines on tumor development -- IL-17 and TH17 cells in rheumatoid arthritis and other inflammatory conditions -- Targeting Th17 Cells for therapy of multiple sclerosis -- Involvement of interleukin-17 cytokines in human asthma -- IL-17 and/or IL-22 as potential target(s) for Crohn's disease -- Role of IL-23, IL-17 and IL-22 in psoriasis -- Contribution of IL-22 to experimental skin inflammation -- Genetic mouse models to investigate IL-17 responses -- IL-17A as a therapeutic target for autoimmune diseases -- Index.
- Format
- e-Book
- Location
- Online
The Inflammasomes
https://libcat.nshealth.ca/en/permalink/provcat28072
edited by Isabelle Couillin, Virginie Pétrilli, Fabio Martinon.
--Basel:
Springer Basel AG
, c2011.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Author
- Couillin, Isabelle
- Other Authors
- Pétrilli, Virginie
- Martinon, Fabio
- Responsibility
- edited by Isabelle Couillin, Virginie Pétrilli, Fabio Martinon
- Place of Publication
- Basel
- Publisher
- Springer Basel AG
- Date of Publication
- c2011
- Series Title
- Progress in inflammation research
- ISBN
- 9783034801485
- Subjects (MeSH)
- Inflammasomes
- Inflammation Mediators
- Subjects (LCSH)
- Biochemistry
- Immunology
- Format
- e-Book
- Location
- Online
Inflammatory Cardiomyopathy (DCMi) : Pathogenesis and Therapy
https://libcat.nshealth.ca/en/permalink/provcat28354
edited by Heinz-Peter Schultheiss, Michel Noutsias.
--Basel:
Birkhäuser Verlag
, c2010.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Author
- Schultheiss, Heinz-Peter
- Other Authors
- Noutsias, Michel
- Responsibility
- edited by Heinz-Peter Schultheiss, Michel Noutsias
- Place of Publication
- Basel
- Publisher
- Birkhäuser Verlag
- Date of Publication
- c2010
- Series Title
- Progress in inflammation research
- ISBN
- 9783764383527
- Subjects (MeSH)
- Cardiomyopathy, Dilated
- Myocarditis
- Format
- e-Book
- Location
- Online
In Vivo Models of Inflammation. Volume I
https://libcat.nshealth.ca/en/permalink/provcat40557
Christopher S. Stevenson, Lisa A. Marshall, Douglas W. Morgan, editors.
(2nd ed.)
--Basel:
Birkhäuser Verlag
, c2006.
- Available Online
- View e-Book
- Location
- Online
In Vivo Models of Inflammation provides the biomedical researcher in both the pharmaceutical industry and academia with a description of the state of the art animal model systems used to emulate diseases with components of inflammation. This second edition acts as a complement to the first edition by describing and updating the standard models that are most utilized for specific disease areas. In addition, new models are included exploring emerging areas of inflammation research. The format is …
- Available Online
- View e-Book
- Other Authors
- Stevenson, Christopher S
- Marshall, Lisa A
- Morgan, Douglas W
- Responsibility
- Christopher S. Stevenson, Lisa A. Marshall, Douglas W. Morgan, editors
- Edition
- 2nd ed.
- Place of Publication
- Basel
- Publisher
- Birkhäuser Verlag
- Date of Publication
- c2006
- Physical Description
- 1 online resource (xii, 207 p.)
- Series Title
- Progress in inflammation research
- ISBN
- 9783764375201
- 9783764375195 (print ed.)
- Subjects (MeSH)
- Animal Experimentation - standards
- Disease Models, Animal
- Inflammation
- Abstract
- In Vivo Models of Inflammation provides the biomedical researcher in both the pharmaceutical industry and academia with a description of the state of the art animal model systems used to emulate diseases with components of inflammation. This second edition acts as a complement to the first edition by describing and updating the standard models that are most utilized for specific disease areas. In addition, new models are included exploring emerging areas of inflammation research. The format is designed with the laboratory in mind: Both volumes provide detailed descriptions of the methodologies and uses of the most significant models. This includes current information regarding agents that demonstrate efficacy, those that do not and those that can be used as standard controls. The focus remains on those models that serve as pre-clinical correlates to human disease as well as those that represent components of the inflammatory response. Pioneering ideas and provocative comments about future directions are meant to challenge the status quo and stimulate new thinking. Therefore, new approaches to the development of future models in selected therapeutic areas have been highlighted. The focus on novel technologies that are vital for innovative in vivo research has been expanded to include chapters on the use of transgenic and gene transfer technologies, nanotechnology, and stem cells. This up-to-date reference manual helps to select the best animal model for a specific question. At the same time, this set of books continues to acknowledge the solemn responsibility in vivo research carries with it and extends the coverage of animal respect and welfare when used in experimental settings. Chapters describing current regulations in the United States, United Kingdom, and Japan address these concerns. Thus, the ultimate aim of this set of books is to provide current best practices for obtaining the maximum information from in vivo experimentation, while preserving the dignity and comfort of the animal.
- Contents
- Rat models of arthritis: Similarities, differences, advantages, and disadvantages in the identification of novel therapeutics -- Murine collagen induced arthritis -- Use of animal models of osteoarthritis in the evaluation of potential new therapeutic agents -- Models of inflammatory processes in cancer -- Advances in stem cell research: use of stem cells in animal models of muscular dystrophy -- Gene transfer technology -- Transgenics -- Nanotechnology: Towards the detection and treatment of inflammatory diseases -- UK legislation of in vivo aspects in inflammation research -- Japanese guidelines and regulations for scientific and ethical animal experimentation -- United States guidelines and regulations in animal experimentation.
- Format
- e-Book
- Location
- Online
In Vivo Models of Inflammation. Volume II
https://libcat.nshealth.ca/en/permalink/provcat40558
Christopher S. Stevenson, Lisa A. Marshall, Douglas W. Morgan, editors.
(2nd ed.)
--Basel:
Birkhäuser Verlag
, c2006.
- Available Online
- View e-Book
- Location
- Online
In Vivo Models of Inflammation provides the biomedical researcher in both the pharmaceutical industry and academia with a description of the state of the art animal model systems used to emulate diseases with components of inflammation. This second edition acts as a complement to the first edition by describing and updating the standard models that are most utilized for specific disease areas. In addition, new models are included exploring emerging areas of inflammation research. The format is …
- Available Online
- View e-Book
- Other Authors
- Stevenson, Christopher S
- Marshall, Lisa A
- Morgan, Douglas W
- Responsibility
- Christopher S. Stevenson, Lisa A. Marshall, Douglas W. Morgan, editors
- Edition
- 2nd ed.
- Place of Publication
- Basel
- Publisher
- Birkhäuser Verlag
- Date of Publication
- c2006
- Physical Description
- 1 online resource (x, 203 p. : 19 illus.)
- Series Title
- Progress in inflammation research
- ISBN
- 9783764377601
- 9783764377571 (print ed.)
- Subjects (MeSH)
- Disease Models, Animal
- Inflammation
- Abstract
- In Vivo Models of Inflammation provides the biomedical researcher in both the pharmaceutical industry and academia with a description of the state of the art animal model systems used to emulate diseases with components of inflammation. This second edition acts as a complement to the first edition by describing and updating the standard models that are most utilized for specific disease areas. In addition, new models are included exploring emerging areas of inflammation research. The format is designed with the laboratory in mind: Both volumes provide detailed descriptions of the methodologies and uses of the most significant models. This includes current information regarding agents that demonstrate efficacy, those that do not and those that can be used as standard controls. The focus remains on those models that serve as pre-clinical correlates to human disease as well as those that represent components of the inflammatory response. Pioneering ideas and provocative comments about future directions are meant to challenge the status quo and stimulate new thinking. Therefore, new approaches to the development of future models in selected therapeutic areas have been highlighted. The focus on novel technologies that are vital for innovative in vivo research has been expanded to include chapters on the use of transgenic and gene transfer technologies, nanotechnology, and stem cells. This up-to-date reference manual helps to select the best animal model for a specific question. At the same time, this set of books continues to acknowledge the solemn responsibility in vivo research carries with it and extends the coverage of animal respect and welfare when used in experimental settings. Chapters describing current regulations in the United States, United Kingdom, and Japan address these concerns. Thus, the ultimate aim of this set of books is to provide current best practices for obtaining the maximum information from in vivo experimentation, while preserving the dignity and comfort of the animal.
- Contents
- Asthma -- In vivo modeling systems for chronic obstructive pulmonary disease -- Murine models of allergen-induced airway hyperresponsiveness and inflammation -- Skin inflammatory disorders -- In vivo models of neurogenic inflammation -- Animal models of inflammatory bowel disease -- Preclinical models of vascular inflammation.
- Format
- e-Book
- Location
- Online
Lipoxygenases in Inflammation
https://libcat.nshealth.ca/en/permalink/provcat40061
Dieter Steinhilber, editor.
--Cham:
Springer
, c2016.
- Available Online
- View e-Book
- Location
- Online
Oxidation of polyunsaturated fatty acids by lipoxygenases leads to a variety of fatty acid metabolites which play important roles in physiology but also in pathophysiology. Data accumulated during the last decade point to the fact that lipoxygenase metabolites are involved in host defence reactions, cardiovascular system and contribute to the development of inflammatory and allergic diseases, cardiovascular disease and cancer. This PIR volume summarizes the physiological and pathophysiological …
- Available Online
- View e-Book
- Other Authors
- Steinhilber, Dieter
- Responsibility
- Dieter Steinhilber, editor
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2016
- Physical Description
- 1 online resource (xi, 245 p. : 39 illus., 26 illus. in color)
- Series Title
- Progress in inflammation research
- ISBN
- 9783319277660
- 9783319277646 (print ed.)
- Subjects (MeSH)
- Fatty Acids, Unsaturated - metabolism
- Inflammation - physiopathology
- Lipoxygenases - adverse effects
- Lipoxygenases - metabolism
- Lipoxygenases - physiology
- Abstract
- Oxidation of polyunsaturated fatty acids by lipoxygenases leads to a variety of fatty acid metabolites which play important roles in physiology but also in pathophysiology. Data accumulated during the last decade point to the fact that lipoxygenase metabolites are involved in host defence reactions, cardiovascular system and contribute to the development of inflammatory and allergic diseases, cardiovascular disease and cancer. This PIR volume summarizes the physiological and pathophysiological functions of lipoxygenases.
- Contents
- Introduction into lipoxygenases -- 5-Lipoxygenase -- Leukotriene A4 hydrolase and LTC4 synthase -- Catalytic multiplicity of 15-lipoxygenase-1 orthologs (ALOX15) of different species -- Platelets and lipoxygenases -- Lipoxygenases and cardiovascular diseases -- Role of lipoxygenases in pathogenesis of cancer -- The physiology and pathophysiology of lipoxygenases in the skin -- 5-Oxo-ETE and inflammation -- Lipoxins, resolvins, and the resolution of inflammation.
- Format
- e-Book
- Location
- Online
MicroRNAs and Other Non-Coding RNAs in Inflammation
https://libcat.nshealth.ca/en/permalink/provcat39169
Catherine M. Greene, editor.
--Cham:
Springer
, c2015.
- Available Online
- View e-Book
- Location
- Online
The book serves as a comprehensive resource for scientists and clinicians studying the role of non-coding RNAs in inflammation (viral infections, wound inflammation), human inflammatory diseases (i.e. rheumatoid arthritis, Crohn's disease, diabetes), and innate immunity. It provides a universal reference work comprising both basic and specialized information. Given that ncRNAs represent new therapeutic targets, this volume will also be of interest to industrial biomedical researchers and those …
- Available Online
- View e-Book
- Other Authors
- Greene, Catherine M
- Responsibility
- Catherine M. Greene, editor
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2015
- Physical Description
- 1 online resource (x, 237 p. : 17 illus., 16 illus. in color)
- Series Title
- Progress in inflammation research
- ISBN
- 9783319136899
- 9783319136882 (print ed.)
- Subjects (MeSH)
- Biomarkers
- Inflammation - genetics
- MicroRNAs - genetics
- RNA, Long Noncoding - genetics
- Abstract
- The book serves as a comprehensive resource for scientists and clinicians studying the role of non-coding RNAs in inflammation (viral infections, wound inflammation), human inflammatory diseases (i.e. rheumatoid arthritis, Crohn's disease, diabetes), and innate immunity. It provides a universal reference work comprising both basic and specialized information. Given that ncRNAs represent new therapeutic targets, this volume will also be of interest to industrial biomedical researchers and those involved in drug development.
- Contents
- The biology of microRNA -- The biology of long non-coding RNA -- microRNA regulation of neutrophil function -- How non-coding RNAs contribute to macrophage polarization -- Endogenous control of dendritic cell activation by miRNA -- Noncoding RNA expression during viral infection: the long and the short of it -- Wound inflammation: emerging role of miRNA -- The importance of microRNAs in rheumatoid arthritis -- MicroRNAs with impact on adipose tissue inflammation in obesity -- The relationship between miR-29, NOD2 and Crohn's disease -- The role of ncRNA in diabetes -- ncRNA as diagnostics and prognostics for hepatocellular carcinoma.
- Format
- e-Book
- Location
- Online
MIF Family Cytokines in Innate Immunity and Homeostasis
https://libcat.nshealth.ca/en/permalink/provcat41691
Richard Bucala, Jürgen Bernhagen, editors.
--Cham:
Springer
, 2017.
- Available Online
- View e-Book
- Location
- Online
The role of the cytokine macrophage migration inhibitory factor (MIF) in the immune response and in the immunopathogenesis of different inflammatory, autoimmune, and infectious disorders is now well-established. Recent studies continue to broaden considerably the role of MIF in both normal physiology and pathology, which range from such diverse areas as oncogenesis, metabolism, and cellular stress responses. MIFÇÖs molecular mechanism of action in these contexts is becoming increasingly underst…
- Available Online
- View e-Book
- Other Authors
- Bucala, Richard
- Bernhagen, Jürgen
- Responsibility
- Richard Bucala, Jürgen Bernhagen, editors
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- 2017
- Physical Description
- 1 online resource (viii, 246 pages) : 37 illus., 25 illus. in color
- Series Title
- Progress in inflammation research
- ISBN
- 9783319523545
- 9783319523521 (print ed.)
- Subjects (MeSH)
- Homeostasis - immunology
- Immunity, Innate - immunology
- Macrophage Migration-Inhibitory Factors - adverse effects
- Macrophage Migration-Inhibitory Factors - immunology
- Abstract
- The role of the cytokine macrophage migration inhibitory factor (MIF) in the immune response and in the immunopathogenesis of different inflammatory, autoimmune, and infectious disorders is now well-established. Recent studies continue to broaden considerably the role of MIF in both normal physiology and pathology, which range from such diverse areas as oncogenesis, metabolism, and cellular stress responses. MIFÇÖs molecular mechanism of action in these contexts is becoming increasingly understood and the role of variant MIF alleles in different conditions continues to be defined. New family members, such as D-dopachrome tautomerase, or MIF-2, and the closely homologous genes encoding by parasites have been defined and are being functionally characterized. MIF directed therapies also are entering clinical testing and ultimately may be applied in a pharmacogenomics manner. This book provides a comprehensive synthesis of the state-of-the-art of MIF science. The intended audience are post-graduate students and researchers in inflammation, innate immunity, immunology, and immunopathology.
- Contents
- MIF and CD74-dependent Mechanisms -- HSP90-stabilized MIF in Oncogenesis and Cell Growth Control -- CD74, MIF, and Breast Tumorigenesis: Insights from Recent Large-scale Tumor Genomics and Proteomics Studies -- MIF-dependent Regulation of Monocyte/Macrophage Polarization -- Advances in Understanding the Role of MIF in the Pathogenesis of Autoimmune Diseases -- Role of MIF in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis -- Role of MIF in Hepatic Inflammatory Diseases and Fibrosis -- MIF and Pulmonary Disease -- MIF Mediates Pelvic Inflammation and Pain -- MIF Family Proteins in Cardiac Ischemia / Reperfusion Injury -- The MIF-CD74 Inflammatory Axis in Alphaviral Infection -- MIF in Eosinophilic Inflammation -- The Role of MIF in Parasitic Infections -- Parasite MIF Orthologs.
- Format
- e-Book
- Location
- Online
New Therapeutic Targets in Rheumatoid Arthritis
https://libcat.nshealth.ca/en/permalink/provcat29947
edited by Paul-Peter Tak.
--Basel:
Birkhäuser Verlag
, c2009.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Author
- Tak, Paul-Peter
- Responsibility
- edited by Paul-Peter Tak
- Place of Publication
- Basel
- Publisher
- Birkhäuser Verlag
- Date of Publication
- c2009
- Series Title
- Progress in inflammation research
- ISBN
- 9783764382384
- Subjects (MeSH)
- Antirheumatic Agents
- Arthritis, Rheumatoid - drug therapy
- Format
- e-Book
- Location
- Online
Next-Generation Therapies and Technologies for Immune-Mediated Inflammatory Diseases
https://libcat.nshealth.ca/en/permalink/provcat41415
Paola Mina-Osorio, editor.
--Cham:
Springer
, 2017.
- Available Online
- View e-Book
- Location
- Online
As our understanding of immune mediated chronic inflammatory diseases (IMIDs) grows, it becomes more and more clear that these conditions result from the convergence of a multitude of pathogenic mechanisms whose relative individual contribution is different in different patient subsets. Promising new technologies have been conceived that address the hypotheses that targeting multiple pathways simultaneously, selectively delivering therapeutics to areas of inflammation and/or resetting the immun…
- Available Online
- View e-Book
- Other Authors
- Mina-Osorio, Paola
- Responsibility
- Paola Mina-Osorio, editor
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- 2017
- Physical Description
- 1 online resource (xi, 202 pages) : 8 illus., 6 illus. in color
- Series Title
- Progress in inflammation research
- ISBN
- 9783319422527
- 9783319422510 (print ed.)
- Subjects (MeSH)
- Immune System Diseases - therapy
- Inflammation - immunology
- Abstract
- As our understanding of immune mediated chronic inflammatory diseases (IMIDs) grows, it becomes more and more clear that these conditions result from the convergence of a multitude of pathogenic mechanisms whose relative individual contribution is different in different patient subsets. Promising new technologies have been conceived that address the hypotheses that targeting multiple pathways simultaneously, selectively delivering therapeutics to areas of inflammation and/or resetting the immune system, could take efficacy to new levels. However, we have long waited for the arrival of some of these technologies to the bedside, or even far enough in the drug development process in spite of the initial enthusiasm. Some of the examples covered in this book include bispecific antibodies and genomic medicines, microparticles and targeted delivery of drugs to inflamed vasculature. Most published reviews and book chapters on novel therapies for inflammatory diseases describe positive attributes of molecules or technologies under investigation and the rationale for developing them into therapeutics. The originality and potential value of this book is not in the description of these targets or technologies from the point of view of their structure or mechanism of action exclusively, but rather, in making an effort to critically address the question of what is needed to move these technologies into the clinic. Has the technology not made it past the preclinical stage and why? Has it already been tested in humans and failed? What are the potential reasons behind those failures? What do experts in each field believe can be done better to increase the probabilities of success? In addition, the authors address the competitive landscape and summarize clinical studies that have failed in the respective area. They talk about the patient populations that would be required for the successful conduction of a clinical trial to test certain molecules, and they proactively share their views regarding both the potential and the drawbacks of targets or methodologies.
- Contents
- Part I. Diagnosis, Patient Stratification and Biomarkers -- A Tale of Two Worlds: Pharmaceutical Investigators and Clinicians Define “Diagnosis” -- Biomarkers in Clinical Trials for Rheumatoid Arthritis -- The Role of Microparticles as Biomarkers in the Development of Therapy for Autoimmune Disease -- Part II. Genomic Medicine -- The Future for Genomic Medicine in Inflammatory Diseases -- Part III. Bispecific Antibodies -- Bispecific Antibodies -- Part IV. Cross-Functional Targets -- Targeting CD13 with Asn-Gly-Arg (NGR) Peptide-Drug Conjugates -- Energy Homeostasis of Immune Cells: Translating Cell Bioenergetics into Clinical Application in Rheumatoid Arthritis -- The Intestinal Microbiome, the Immune System and Spondyloarthropathy -- Stem Cell Therapy in the Treatment of Rheumatic Diseases and Application in the Treatment of Systemic Lupus Erythematosus.
- Format
- e-Book
- Location
- Online
Occupational Asthma
https://libcat.nshealth.ca/en/permalink/provcat29564
edited by Torben Sigsgaard, Dick Heederik.
--Basel:
Birkhäuser Verlag
, c2010.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Author
- Sigsgaard, Torben
- Other Authors
- Heederik, Dick
- Responsibility
- edited by Torben Sigsgaard, Dick Heederik
- Place of Publication
- Basel
- Publisher
- Birkhäuser Verlag
- Date of Publication
- c2010
- Series Title
- Progress in inflammation research
- ISBN
- 9783764385569
- Subjects (MeSH)
- Asthma - etiology
- Asthma - diagnosis
- Occupational Diseases - etiology
- Air Pollutants, Occupational - adverse effects
- Format
- e-Book
- Location
- Online
