series:"Recent results in cancer research" found 49 records - Provincial Hospitals Library Catalogue

This issue of Recent Results in Cancer Research presents a comprehensive review of current understanding of chromosomal instability in cancer and of strategies to use this information for better treatment of patients with cancer. Cancer is a disease of the chromosomes, and chromosomal instability in cancer disrupts gene function by either inactivating tumor suppressor genes or activating growth-promoting oncogenes. The chromosomal basis for these aberrations is either translocations, which chan…

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Other Authors: Ghadimi, B. Michael; Ried, Thomas

Responsibility: B. Michael Ghadimi, Thomas Ried, editors

Edition: 1st ed.

Place of Publication: Cham

Publisher: Springer

Date of Publication: c2015

Physical Description: 1 online resource (vii, 224 p. : 39 illus. in color)

Series Vol.: 200

Series Title: Recent results in cancer research

ISBN: 9783319202914; 9783319202907 (print ed.)

ISSN: 0080-0015

Subjects (MeSH): Aneuploidy; Chromosomal Instability - genetics; Gene Expression Regulation, Neoplastic - genetics; Neoplasms - genetics; Translocation, Genetic

Abstract: This issue of Recent Results in Cancer Research presents a comprehensive review of current understanding of chromosomal instability in cancer and of strategies to use this information for better treatment of patients with cancer. Cancer is a disease of the chromosomes, and chromosomal instability in cancer disrupts gene function by either inactivating tumor suppressor genes or activating growth-promoting oncogenes. The chromosomal basis for these aberrations is either translocations, which change the integrity of genes, or abnormal numbers of chromosomes, a condition referred to as aneuploidy, which results in abnormal gene expression levels. Such structural or numerical chromosomal aberrations are specific for distinct tumor entities. The degree of chromosomal instability and the degree of intratumor heterogeneity have profound consequences for disease outcome and for therapeutic stratification.

Contents: DNA Repair and Chromosomal Translocations -- CINcere modelling: What have mouse models for chromosome instability taught us? -- Telomere Dysfunction, Chromosomal Instability and Cancer -- Genetic Instability and Disease Prognostication -- Causes of Chromosomal Instability -- Patterns of Chromosomal Aberrations in Solid Tumors -- Yeast as Models of Mitotic Fidelity -- The Diverse Effects of Complex Chromosome Rearrangements and Chromothripsis in Cancer Development. -- Consequences of Aneuploidy in Cancer: Transcriptome and Beyond.

Format: e-Book

Location: Online

Clinical Cancer Prevention

https://libcat.nshealth.ca/en/permalink/provcat29112

edited by Hans-Jörg Senn, Florian Otto. --Berlin, Heidelberg: Springer-Verlag , c2011.

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Location: Online

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Author: Senn, Hans-Jörg

Other Authors: International Conference on Clinical Cancer Prevention (6th : 2010 : St. Gallen, Switzerland)

Other Authors: Otto, Florian

Responsibility: edited by Hans-Jörg Senn, Florian Otto

Place of Publication: Berlin, Heidelberg

Publisher: Springer-Verlag

Date of Publication: c2011

Series Vol.: 188

Series Title: Recent results in cancer research

ISBN: 9783642108587

Subjects (MeSH): Chemoprevention - Congresses; Neoplasms - prevention & control - Congresses

Subjects (LCSH): Oncology

Format: e-Book

Location: Online

Communication in Cancer Care

https://libcat.nshealth.ca/en/permalink/provcat28561

edited by Friedrich Stiefel. --Berlin, Heidelberg: Springer-Verlag , c2006.

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Location: Online

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Author: Stiefel, Friedrich

Responsibility: edited by Friedrich Stiefel

Place of Publication: Berlin, Heidelberg

Publisher: Springer-Verlag

Date of Publication: c2006

Series Vol.: 168

Series Title: Recent results in cancer research

ISBN: 9783540307587

Subjects (MeSH): Neoplasms - psychology; Physician-Patient Relations

Subjects (LCSH): Oncology

Format: e-Book

Location: Online

Current Strategies in Cancer Gene Therapy

https://libcat.nshealth.ca/en/permalink/provcat41069

Wolfgang Walther, editor. --Cham: Springer , c2016.

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Location: Online

This book describes important developments and emerging trends in experimental and clinical cancer gene therapy. It reflects the tremendous advances made over recent years with respect to immunogenes, suicide genes and gene correction therapies, as well as in gene suppression and miRNA therapies. Many of the described strategies focus on the generation of more efficient and specific means of attack at known and novel cellular targets associated with tumor development and progression. The book a…

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Other Authors: Walther, Wolfgang

Responsibility: Wolfgang Walther, editor

Place of Publication: Cham

Publisher: Springer

Date of Publication: c2016

Physical Description: 1 online resource (v, 121 p.) : 13 illus., 7 illus. in color

Series Vol.: 209

Series Title: Recent results in cancer research

ISBN: 9783319429342; 9783319429328 (print ed.)

ISSN: 0080-0015

Subjects (MeSH): Genetic therapy - methods; Neoplasms - therapy

Abstract: This book describes important developments and emerging trends in experimental and clinical cancer gene therapy. It reflects the tremendous advances made over recent years with respect to immunogenes, suicide genes and gene correction therapies, as well as in gene suppression and miRNA therapies. Many of the described strategies focus on the generation of more efficient and specific means of attack at known and novel cellular targets associated with tumor development and progression. The book also details parallel improvements in vector design, vector delivery, and therapeutic efficacy. It offers readers a stimulating, broad overview of advances in the field, linking experimental strategies to their clinical applications.

Contents: p53 Replacement Therapy for Cancer -- Retroviral Vectors for Cancer Gene Therapy -- Minicircle-Based Engineering of Chimeric Antigen Receptor (CAR) T Cells -- Noncoding RNA for Cancer Gene Therapy -- mRNA Cancer Vaccines -- Gene Therapeutic Approaches to Overcome ABCB1-Mediated Drug Resistance -- Bacterial Toxins for Oncoleaking Suicidal Cancer Gene Therapy -- Use of Bacteria in Cancer Therapy.

Format: e-Book

Location: Online

Early Gastrointestinal Cancers

https://libcat.nshealth.ca/en/permalink/provcat31195

Florian Otto, Manfred P. Lutz, editors. --Berlin, Heidelberg: Springer , c2012.

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Location: Online

This Recent Results in Cancer Research volume contains the majority of the invited expert contributions from the First St. Gallen EORTC Gastrointestinal Cancer Conference, held on 22-24 March 2012 in St. Gallen, Switzerland. Written by some of the world's leading experts in the field, the volume constitutes a comprehensive update on recent developments in the imaging, molecular biology, pathology, and multidisciplinary management of early cancer of the gastrointestinal tract. The latest recomme…

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Other Authors: St Gallen EORTC Gastrointestinal Cancer Conference (1st : 2012 : Saint Gallen, Switzerland)

Other Authors: Otto, Florian; Lutz, Manfred P

Responsibility: Florian Otto, Manfred P. Lutz, editors

Place of Publication: Berlin, Heidelberg

Publisher: Springer

Date of Publication: c2012

Physical Description: 1 online resource (xii, 318 p. : 36 ill., 33 ill. in color)

Series Vol.: 196

Series Title: Recent results in cancer research

ISBN: 9783642316296

Subjects (MeSH): Early Detection of Cancer; Early Medical Intervention; Gastrointestinal Neoplasms - diagnosis; Gastrointestinal Neoplasms - therapy

Subjects (LCSH): Gastroenterology; Oncology

Abstract: This Recent Results in Cancer Research volume contains the majority of the invited expert contributions from the First St. Gallen EORTC Gastrointestinal Cancer Conference, held on 22-24 March 2012 in St. Gallen, Switzerland. Written by some of the world's leading experts in the field, the volume constitutes a comprehensive update on recent developments in the imaging, molecular biology, pathology, and multidisciplinary management of early cancer of the gastrointestinal tract. The latest recommendations regarding diagnosis and treatment are provided, and areas of consensus and controversy, identified. While the principal focus is on esophageal and gastric cancer, advances in the treatment of colorectal and pancreatic cancer are also discussed in some detail. This book will be of interest to every clinician involved in the care of patients with gastrointestinal malignancies.

Contents: Clinically relevant study end points in rectal cancer -- Neoadjuvant treatment in rectal cancer : do we always need radiotherapy or can we risk assess locally advanced rectal cancer better? -- Treatment dilemmas in patients with synchronous colorectal liver metastases -- Pancreatic surgery : beyond the traditional limits -- Adjuvant therapy for pancreatic cancer -- Radiotherapy of the pancreas : state of the art in 2012 -- Adenocarcinoma of the GEJ : gastric or oesophageal cancer? -- Why is there a change in patterns of GE cancer? -- Endoscopic treatment for esophageal squamous cell carcinoma -- Open or minimally invasive resection for oesophageal cancer? -- Choosing the best treatment for esophageal cancer -- Multimodal therapy of GEJ cancer : when is the definitive radiochemotherapy the treatment of choice? -- Radiotherapy of gastroesophageal junction cancer -- Optimizing neoadjuvant chemotherapy through the use of early response evaluation by positron emission tomography -- Optimal surgery for gastric cancer : is more always better? -- Can adjuvant chemoratiotherapy replace extended lymph node dissection in gastric cancer? -- Predicting the response to chemotherapy in gastric adenocarcinoma : who benefits from neoadjuvant chemotherapy? -- Prediction of response and prognosis by a score including only pretherapeutic parameters in 410 neoadjuvant treated gastric cancer patients -- Adjuvant chemotherapy : an option for Asian patients only? -- Selecting the best treatment for an individual patient.

Format: e-Book

Location: Online

Early gastrointestinal cancers II : rectal cancer

https://libcat.nshealth.ca/en/permalink/provcat34050

Florian Otto, Manfred P. Lutz, editors. --Cham, Switzerland: Springer , c2014.

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Location: Online

This Recent Results in Cancer Research volume provides an up-to-date overview of the multidisciplinary management of locally confined rectal cancer as well as colorectal cancer with synchronous resectable liver metastases. The contents comprise the majority of the invited contributions from the Second St. Gallen EORTC Gastrointestinal Cancer Conference, held on 6-8 March 2014 in St. Gallen, Switzerland. Written by some of the world's leading experts in the imaging, endoscopy, pathology, molecul…

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Other Authors: St. Gallen EORTC Gastrointestinal Cancer Conference (2nd : 2014 : Saint Gallen, Switzerland)

Other Authors: Otto, Florian; Lutz, Manfred P.

Responsibility: Florian Otto, Manfred P. Lutz, editors

Alternate Title: Rectal cancer

Place of Publication: Cham, Switzerland

Publisher: Springer

Date of Publication: c2014

Physical Description: 1 online resource (viii, 252 pages)

Series Vol.: v. 203

Series Title: Recent results in cancer research

ISBN: 9783319080604 (electronic bk.); 9783319080598

Subjects (MeSH): Early Detection of Cancer; Early Medical Intervention; Rectal Neoplasms - diagnosis; Rectal Neoplasms - therapy

Subjects (LCSH): Rectum - Cancer - Congresses; Surgical oncology; Gastroenterology

Abstract: This Recent Results in Cancer Research volume provides an up-to-date overview of the multidisciplinary management of locally confined rectal cancer as well as colorectal cancer with synchronous resectable liver metastases. The contents comprise the majority of the invited contributions from the Second St. Gallen EORTC Gastrointestinal Cancer Conference, held on 6-8 March 2014 in St. Gallen, Switzerland. Written by some of the world's leading experts in the imaging, endoscopy, pathology, molecular biology, surgery, radiotherapy, and medical oncology of rectal cancer and liver metastases, the chapters offer a comprehensive view on the latest recommendations in diagnosis and multidisciplinary treatment.

Contents: Part I. Staging of Rectal Cancer -- Imaging Assessment of Early Rectal Cancer -- Predicting Lymph Node Metastases in pT1 Rectal Cancer -- Part II. Treatment of Early Rectal Cancer -- Endoscopic Resection: When Is EMR/ESD Sufficient? -- Transanal Endoscopic Microsurgery -- Part III. Surgical Treatment of Rectal Cancer -- What Is ‘‘Good Quality’’ in Rectal Cancer Surgery? The Pathologist’s Perspective -- Total Mesorectal Excision: Open, Laparoscopic or Robotic -- Ultra Low Resection Versus Abdomino-Perineal Excision in Low Rectal Cancer -- T4 Rectal Cancer: Do We Always Need an Exenteration? -- Do T3 Rectal Cancers Always Need Radiochemotherapy? -- Quality of Life After Surgery for Rectal Cancer -- Part IV. Combined Modality Therapy in Rectal Cancer -- Aims of Combined Modality Therapy in Rectal Cancer (M0) -- Neoadjuvant Radiotherapy (5 3 5 Gy): Immediate Versus Delayed Surgery -- Early and Late Toxicity of Radiotherapy for Rectal Cancer -- Immediate Surgery or Clinical Follow-Up After a Complete Clinical Response? -- Part V. Rectal Cancer with Synchronous Liver Metastases -- Limits of Colorectal Liver Metastases Resectability: How and Why to Overcome Them? -- Rectal Cancer with Synchronous Liver Metastases: Leave It All in? When (not) to Resect the Primary? -- Recurrence Patterns After Resection of Liver Metastases from Colorectal Cancer.

Format: e-Book

Location: Online

Ethical Challenges in Cancer Diagnosis and Therapy

https://libcat.nshealth.ca/en/permalink/provcat46862

Axel W. Bauer, Ralf-Dieter Hofheinz, Jochen S. Utikal. Springer , 2021.

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Location: Online

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Responsibility: Axel W. Bauer, Ralf-Dieter Hofheinz, Jochen S. Utikal

Publisher: Springer

Date of Publication: 2021

Physical Description: 1 online resource (xii, 290 pages) : illustrations

Series Vol.: 218

Series Title: Recent results in cancer research

ISBN: 9783030637491

Specialty: Medical Oncology; Neoplasms

Format: e-Book

Location: Online

Gliomas

https://libcat.nshealth.ca/en/permalink/provcat28760

edited by Andreas Deimling. --Berlin, Heidelberg: Springer , c2009.

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Location: Online

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Author: Deimling, Andreas

Responsibility: edited by Andreas Deimling

Place of Publication: Berlin, Heidelberg

Publisher: Springer

Date of Publication: c2009

Series Vol.: 171

Series Title: Recent results in cancer research

ISBN: 9783540312062

Subjects (MeSH): Glioma - diagnosis; Glioma - therapy

Subjects (LCSH): Neurology; Oncology

Format: e-Book

Location: Online

HPV Infection in Head and Neck Cancer

https://libcat.nshealth.ca/en/permalink/provcat41484

Wojciech Golusinski, C. René Leemans, Andreas Dietz. --Cham: Springer , 2017.

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Location: Online

This book is exceptional in presenting an interdisciplinary approach to the subject of human papillomavirus (HPV) infection in the context of head and neck cancer. Leading experts in the field discuss the epidemiology and molecular biology of HPV-positive head and neck squamous cell carcinoma, HPV testing, the nonsurgical and surgical treatment of HPV-positive tumors, predictive factors for outcome and quality of life, and ongoing trials on the effectiveness of vaccination in disease prevention…

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Other Authors: Golusinski, Wojciech; Leemans, C. René; Dietz, Andreas

Responsibility: Wojciech Golusinski, C. René Leemans, Andreas Dietz

Place of Publication: Cham

Publisher: Springer

Date of Publication: 2017

Physical Description: 1 online resource (vi, 267 pages) : 42 illus., 29 illus. in color

Series Vol.: 206

Series Title: Recent results in cancer research

ISBN: 9783319435800; 9783319435787 (print ed.)

ISSN: 0080-0015

Subjects (MeSH): Carcinoma, Squamous Cell; Head and Neck Neoplasms; Papillomaviridae - pathogenicity; Papillomavirus Infections; Papillomavirus Vaccines - therapeutic use

Abstract: This book is exceptional in presenting an interdisciplinary approach to the subject of human papillomavirus (HPV) infection in the context of head and neck cancer. Leading experts in the field discuss the epidemiology and molecular biology of HPV-positive head and neck squamous cell carcinoma, HPV testing, the nonsurgical and surgical treatment of HPV-positive tumors, predictive factors for outcome and quality of life, and ongoing trials on the effectiveness of vaccination in disease prevention. It also provides recommendations for testing, diagnosis treatment and vaccination. Otolaryngologists, head and neck surgeons, medical oncologists, radiation oncologists, molecular biologists and pathologists will find this book a valuable resource.

Contents: Part I. Epidemiology and molecular biology of HPV positive HNSCC -- Part II. HPV testing -- Part III. Non-surgical treatment of HPV positive tumours -- Part IV. Surgical treatment of HPV positive tumours -- Part V. Predictive factors for outcome and quality of life in HPV positive and HPV negative -- Part VI. HPV : prevention vaccination, ongoing trials.

Format: e-Book

Location: Online

Inflammation and Gastrointestinal Cancers

https://libcat.nshealth.ca/en/permalink/provcat28687

edited by Janusz A. Z. Jankowski. --Berlin, Heidelberg: Springer-Verlag , c2011.

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Location: Online

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Author: Jankowski, Janusz A. Z

Responsibility: edited by Janusz A. Z. Jankowski

Place of Publication: Berlin, Heidelberg

Publisher: Springer-Verlag

Date of Publication: c2011

Series Vol.: 185

Series Title: Recent results in cancer research

ISBN: 9783642035036

Subjects (MeSH): Gastrointestinal Neoplasms - etiology; Inflammation - complications

Subjects (LCSH): Gastroenterology; Oncology

Format: e-Book

Location: Online

Malignant Mesothelioma

https://libcat.nshealth.ca/en/permalink/provcat30160

edited by Andrea Tannapfel. --Berlin, Heidelberg: Springer-Verlag , c2011.

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Location: Online

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Author: Tannapfel, Andrea

Responsibility: edited by Andrea Tannapfel

Place of Publication: Berlin, Heidelberg

Publisher: Springer-Verlag

Date of Publication: c2011

Series Vol.: 189

Series Title: Recent results in cancer research

ISBN: 9783642108624

Subjects (MeSH): Asbestos - adverse effects; Mesothelioma

Subjects (LCSH): Oncology; Pneumology

Format: e-Book

Location: Online

Medullary Thyroid Carcinoma : Biology, Management, Treatment

https://libcat.nshealth.ca/en/permalink/provcat39384

Friedhelm Raue, editor. --Cham: Springer , c2015.

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Location: Online

This book offers a comprehensive overview of medullary thyroid carcinoma, both in the more common sporadic form and in the familial form, multiple endocrine neoplasia (MEN) types 2A and 2B. The coverage includes, but is not limited to, molecular biology and genetics, pathology, clinical presentation, imaging techniques, surgical treatment, and follow-up. The role of calcitonin as a highly sensitive and specific tumor marker for the screening, diagnosis, and follow-up of MTC and metastatic disea…

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Other Authors: Raue, Friedhelm

Responsibility: Friedhelm Raue, editor

Place of Publication: Cham

Publisher: Springer

Date of Publication: c2015

Physical Description: 1 online resource (viii, 249 p. : 50 illus., 28 illus. in color)

Series Vol.: 204

Series Title: Recent results in cancer research

ISBN: 9783319225425; 9783319225418 (print ed.)

ISSN: 0080-0015

Subjects (MeSH): Carcinoma, Medullary - diagnosis; Carcinoma, Medullary - genetics; Carcinoma, Medullary - therapy; Thyroid Neoplasms - genetics

Abstract: This book offers a comprehensive overview of medullary thyroid carcinoma, both in the more common sporadic form and in the familial form, multiple endocrine neoplasia (MEN) types 2A and 2B. The coverage includes, but is not limited to, molecular biology and genetics, pathology, clinical presentation, imaging techniques, surgical treatment, and follow-up. The role of calcitonin as a highly sensitive and specific tumor marker for the screening, diagnosis, and follow-up of MTC and metastatic disease is described, and the significance of other tumor markers is also considered. With regard to treatment, the use of thyroidectomy is fully discussed, including in children carrying the mutations in the RET proto-oncogene considered causative for MEN 2. Additionally, the value of tyrosine kinase inhibitors as the most effective treatment modality in patients with a large tumor burden or rapid tumor growth, or both, is explained. Medullary Thyroid Carcinoma and Multiple Endocrine Neoplasia Type 2 will be an ideal source of up-to-date information for a wide range of practitioners, including endocrinologists, oncologists, internal medicine specialists, geneticists, and nuclear medicine physicians.

Contents: Thyroid C-Cell Biology and Oncogenic Transformation -- Histopathology of C cells and medullary thyroid carcinoma -- Epidemiology and clinical presentation of Medullary Thyroid Carcinoma -- Medullary thyroid carcinoma: Imaging -- Calcitonin as a Biomarker for Medullary Thyroid Carcinoma -- Hereditary Medullary Thyroid Cancer, Genotype phenotype correlation -- Pheochromocytomas in Multiple Endocrine Neoplasia 2 -- Primary hyperparathyroidism in Multiple Endocrine Neoplasia 2 Syndrome -- Surgical treatment of medullary thyroid carcinoma -- Long term follow up in medullary thyroid carcinoma -- Use of Tyrosine Kinase Inhibitors for Treatment of Medullary Thyroid Carcinoma.

Format: e-Book

Location: Online

Metabolism in Cancer

https://libcat.nshealth.ca/en/permalink/provcat40307

Thorsten Cramer, Clemens A. Schmitt, editors. --Cham: Springer , c2016.

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Location: Online

This textbook presents concise chapters written by internationally respected experts on various important aspects of cancer-associated metabolism, offering a comprehensive overview of the central features of this exciting research field. The discovery that tumor cells display characteristic alterations of metabolic pathways has significantly changed our understanding of cancer: while the first description of tumor-specific changes in cellular energetics was published more than 90 years ago, the…

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Other Authors: Cramer, Thorsten; A. Schmitt, Clemens

Responsibility: Thorsten Cramer, Clemens A. Schmitt, editors

Place of Publication: Cham

Publisher: Springer

Date of Publication: c2016

Physical Description: 1 online resource (ix, 266 p. : 31 illus., 25 illus. in color)

Series Vol.: 207

Series Title: Recent results in cancer research

ISBN: 9783319421186; 9783319421162 (print ed.)

ISSN: 0080-0015

Subjects (MeSH): Neoplasms - genetics; Neoplasms - metabolism; Neoplastic Processes

Abstract: This textbook presents concise chapters written by internationally respected experts on various important aspects of cancer-associated metabolism, offering a comprehensive overview of the central features of this exciting research field. The discovery that tumor cells display characteristic alterations of metabolic pathways has significantly changed our understanding of cancer: while the first description of tumor-specific changes in cellular energetics was published more than 90 years ago, the causal significance of this observation for the pathogenesis of cancer was only discovered in the post-genome era. The first 10 years of the twenty-first century were characterized by rapid advances in our grasp of the functional role of cancer-specific metabolism as well as the underlying molecular pathways. Various unanticipated interrelations between metabolic alterations and cancer-driving pathways were identified and currently await translation into diagnostic and therapeutic applications. Yet the speed, quantity, and complexity of these new discoveries make it difficult for researchers to keep up to date with the latest developments, an issue this book helps to remedy.

Contents: The Role of Glucose and Lipid Metabolism in Growth and Survival of Cancer Cells -- Lactate—An Integrative Mirror of Cancer Metabolism -- Metabolic Reprogramming by the PI3K-Akt-mTOR Pathway in Cancer -- MYC, Metabolic Synthetic Lethality, and Cancer -- The Role of pH Regulation in Cancer Progression -- Metabolic Features of Cancer Treatment Resistance -- Tissue-Based Metabolomics to Analyze the Breast Cancer Metabolome -- Imaging of Tumor Metabolism Using Positron Emission Tomography (PET) -- Quantitative Analysis of Cancer Metabolism: From pSIRM to MFA -- Mathematical Modeling of Cellular Metabolism -- Ketogenic Diet and Cancer—a Perspective -- Fasting and Caloric Restriction in Cancer Prevention and Treatment.