Genome Editing in Neurosciences
https://libcat.nshealth.ca/en/permalink/provcat43931
Rudolf Jaenisch, Feng Zhang, Fred Gage, editors.
--Cham:
SpringerOpen
, c2017.
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This book is open access under a CC BY 4.0 license. ; Innovations in molecular biology are allowing neuroscientists to study the brain with unprecedented resolution, from the level of single molecules to integrated gene circuits. Chief among these innovations is the CRISPR-Cas genome editing technology, which has the precision and scalability to tackle the complexity of the brain. This Colloque Médecine et Recherche has brought together experts from around the world that are applying genome edi…
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- Other Authors
- Jaenisch, Rudolf
- Zhang, Feng
- Gage, Fred
- Responsibility
- Rudolf Jaenisch, Feng Zhang, Fred Gage, editors
- Place of Publication
- Cham
- Publisher
- SpringerOpen
- Date of Publication
- c2017
- Physical Description
- 1 online resource (xi, 123 p.) : 16 illus. in color
- Series Title
- Research and perspectives in neurosciences
- ISBN
- 9783319601922
- 9783319601915 (Print ed.)
- 9783319601939 (Print ed.)
- 9783319868011 (Print ed.)
- ISSN
- 0945-6082
- Subjects (MeSH)
- CRISPR-Cas Systems
- Gene Editing
- Nervous System Physiological Phenomena - genetics
- RNA Editing
- Abstract
- This book is open access under a CC BY 4.0 license.
- Innovations in molecular biology are allowing neuroscientists to study the brain with unprecedented resolution, from the level of single molecules to integrated gene circuits. Chief among these innovations is the CRISPR-Cas genome editing technology, which has the precision and scalability to tackle the complexity of the brain. This Colloque Médecine et Recherche has brought together experts from around the world that are applying genome editing to address important challenges in neuroscience, including basic biology in model organisms that has the power to reveal systems-level insight into how the nervous system develops and functions as well as research focused on understanding and treating human neurological disorders.
- Contents
- In vitro modeling of complex neurological diseases -- Aquatic model organisms in neurosciences : the genome editing revolution -- Genome-wide genetic screening in the mammalian CNS -- CRISPR/Cas9-mediated knockin and knockout in zebrafish -- Dissecting the role of synaptic proteins with CRISPR -- Recurrently breaking genes in neural progenitors: potential roles of DNA breaks in neuronal function, degeneration and cancer -- Neuroscience research using non-human primate models and genome editing -- Multiscale genome engineering: genome-wide screens and targeted approaches -- Using genome engineering to understand Huntington’s disease -- Therapeutic gene editing in muscles and muscle stem cells.
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- Open access
- Format
- e-Book
- Location
- Online
Micro-, Meso- and Macro-Connectomics of the Brain
https://libcat.nshealth.ca/en/permalink/provcat43935
Henry Kennedy, David C. Van Essen, Yves Christen, editors.
--Cham:
SpringerOpen
, c2016.
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This book has brought together leading investigators who work in the new arena of brain connectomics. This includes ‘macro-connectome’ efforts to comprehensively chart long-distance pathways and functional networks; ‘micro-connectome’ efforts to identify every neuron, axon, dendrite, synapse, and glial process within restricted brain regions; and ‘meso-connectome’ efforts to systematically map both local and long-distance connections using anatomical tracers. This book highlights cutting-edge m…
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- Other Authors
- Kennedy, Henry
- Van Essen, David C.
- Christen, Yves
- Other Authors
- Fondation IPSEN pour la recherche thérapeutique
- Responsibility
- Henry Kennedy, David C. Van Essen, Yves Christen, editors
- Place of Publication
- Cham
- Publisher
- SpringerOpen
- Date of Publication
- c2016
- Physical Description
- 1 online resource (x, 166 p.) : 32 illus., 28 illus. in color
- Series Title
- Research and perspectives in neurosciences
- ISBN
- 9783319277776
- 9783319277769 (Print ed.)
- 9783319277783 (Print ed.)
- 9783319802145 (Print ed.)
- ISSN
- 0945-6082
- Subjects (MeSH)
- Brain - physiology
- Connectome
- Models, Neurological
- Specialty
- Neurology
- Abstract
- This book has brought together leading investigators who work in the new arena of brain connectomics. This includes ‘macro-connectome’ efforts to comprehensively chart long-distance pathways and functional networks; ‘micro-connectome’ efforts to identify every neuron, axon, dendrite, synapse, and glial process within restricted brain regions; and ‘meso-connectome’ efforts to systematically map both local and long-distance connections using anatomical tracers. This book highlights cutting-edge methods that can accelerate progress in elucidating static ‘hard-wired’ circuits of the brain as well as dynamic interactions that are vital for brain function. The power of connectomic approaches in characterizing abnormal circuits in the many brain disorders that afflict humankind is considered. Experts in computational neuroscience and network theory provide perspectives needed for synthesizing across different scales in space and time. Altogether, this book provides an integrated view of the challenges and opportunities in deciphering brain circuits in health and disease.
- Contents
- Nanoconnectomics -- Inhibitory cell types, circuits and receptive fields in mouse visual cortex -- Form meets function in the brain: observing the activity and structure of specific neural connections -- The network for intracortical communication in mouse visual cortex -- The brain in space -- In-vivo connectivity in monkeys -- Parcellations and connectivity patterns in human and macaque cerebral cortex -- Connectome networks: from cells to systems -- Intra- and inter-hemispheric connectivity supporting hemispheric specialization -- Genetics of the connectome and the ENIGMA project.
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- Open access
- Format
- e-Book
- Location
- Online
Micro-, Meso- and Macro-Dynamics of the Brain
https://libcat.nshealth.ca/en/permalink/provcat43937
György Buzsáki, Yves Christen, editors.
--Cham:
SpringerOpen
, c2016.
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- Online
How does the brain orchestrate perceptions, thoughts, and actions from the activity of its neurons? Addressing these challenging issues requires methods with sufficiently high temporal and spatial resolution of neuronal activity in both local and global networks as well as theories to advance understanding how different levels of brain dynamics interact. This book brings together leading investigators who represent various aspects of brain dynamics with the goal of presenting state-of-the-art c…
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- Other Authors
- Buzsáki, György
- Christen, Yves
- Responsibility
- György Buzsáki, Yves Christen, editors
- Place of Publication
- Cham
- Publisher
- SpringerOpen
- Date of Publication
- c2016
- Physical Description
- 1 online resource (xiii, 172 p.) : 33 illus., 30 illus. in color
- Series Title
- Research and perspectives in neurosciences
- ISBN
- 9783319288024
- 9783319288017 (Print ed.)
- 9783319288031 (Print ed.)
- 9783319804293 (Print ed.)
- ISSN
- 0945-6082
- Subjects (MeSH)
- Brain - physiology
- Neuropsychology
- Psychophysiology
- Specialty
- Neurology
- Abstract
- How does the brain orchestrate perceptions, thoughts, and actions from the activity of its neurons? Addressing these challenging issues requires methods with sufficiently high temporal and spatial resolution of neuronal activity in both local and global networks as well as theories to advance understanding how different levels of brain dynamics interact. This book brings together leading investigators who represent various aspects of brain dynamics with the goal of presenting state-of-the-art current progress and address future developments. The topics cover the most fascinating facets of neuroscience from elementary computation of neurons, mesoscopic network oscillations, internally generated assembly sequences in the service of cognition, large-scale neuronal interactions within and across systems, the impact of sleep on cognition, memory and mental illness, brain controlled robots, motor-sensory integration, spatial navigation, large-scale computation and consciousness. Overall, this volume offers an integrated view of the challenges and opportunities in deciphering brain circuits in health and disease.
- Contents
- Hippocampal mechanisms for the segmentation of space by goals and boundaries -- Cortical evolution: introduction to the reptilian cortex -- Flow of information underlying a tactile decision in mice -- The visual brain: computing through multiscale complexity -- Grid cells and spatial maps in entorhinal cortex and hippocampus -- The striatum and decision-making based on value -- Decoding the dynamics of conscious perception: The temporal generalization method -- Sleep and synaptic down-selection -- Psyche, signals and systems -- Federating and integrating what we know about the brain at all scales: computer science meets the clinical neurosciences.
- Access
- Open access
- Format
- e-Book
- Location
- Online
