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Tumors of the Central Nervous System. Vol. 1, Gliomas, Glioblastoma (Part 1)

https://libcat.nshealth.ca/en/permalink/provcat40903
edited by M. A. Hayat. --Dordrecht: Springer , c2011.
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The most recent developments in diagnostic and therapeutic aspects of Gliomas (Glioblastoma) in the brain are presented. The importance of personalized medicine and clinical validation for targeted therapy are discussed. The identification of various types of biomarkers is included. The identification and validation of brain cancer (glioblastoma) genes are discussed. Role of cancer stem cells in the initiation, progression, and persistence of malignant gliomas is explained. The use of surgical …
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Other Authors
Hayat, M. A
Responsibility
edited by M. A. Hayat
Place of Publication
Dordrecht
Publisher
Springer
Date of Publication
c2011
Physical Description
1 online resource (xxi, 434 p.)
Series Vol.
v. 1
Series Title
Tumors of the central nervous system
ISBN
9789400703445
9789400703438 (print ed.)
Subjects (MeSH)
Antineoplastic Agents - therapeutic use
Biomarkers
Brain neoplasms - diagnosis
Brain neoplasms - therapy
Glioblastoma - diagnosis
Glioblastoma - therapy
Glioma - diagnosis
Glioma - therapy
Abstract
The most recent developments in diagnostic and therapeutic aspects of Gliomas (Glioblastoma) in the brain are presented. The importance of personalized medicine and clinical validation for targeted therapy are discussed. The identification of various types of biomarkers is included. The identification and validation of brain cancer (glioblastoma) genes are discussed. Role of cancer stem cells in the initiation, progression, and persistence of malignant gliomas is explained. The use of surgical resection, chemotherapy (e.g., temozolomide), immunotherapy, and radiotherapy for malignant glioblastoma are pointed out. Standard (established) as well as newer imaging modalities (proton magnetic resonance spectroscopy) are discussed.
Contents
Part I. Introduction -- 1. Introduction -- 2. Molecular Classification of Gliomas -- Part II. Biomarkers and Diagnosis -- 3. Glioblastoma: Endosialin Marker for Pericytes -- 4. Glioma Grading Using Cerebral Blood Volume Heterogeneity -- 5. The Role of Ectonucleotidases in Glioma Cell Proliferation -- 6. Gliomas: Role of Monoamine Oxidase B in Diagnosis -- 7. Glioma: Role of Integrin in Pathogenesis and Therapy -- 8. Proton Magnetic Resonance Spectroscopy in Intracranial Gliomas -- 9. Infiltration Zone in Glioma: Proton Magnetic Resonance Spectroscopic Imaging -- 10. Malignant Gliomas: Role of E2F1 Transcription Factor -- 11. The Role of Glucose Transporter-1 (GLUT-1) in Malignant Gliomas -- 12. Malignant Gliomas: Role of Platelet-Derived Growth Factor Receptor A (PDGFRA) -- 13. Molecular Methods for Detection of Tumor Markers in Glioblastomas -- 14. Role of MGMT in Glioblastomas -- 15. Glioblastomas: Role of CXCL12 Chemokine -- 16. Cell Death Signaling in Glioblastoma Multiforme: Role of the Bcl2L12 Oncoprotein -- 17. Glioblastoma Multiforme: Role of Polycomb Group Proteins -- 18. Glioblastoma Multiforme: Role of Cell Cycle-Related Kinase Protein (Method) -- Part III. Neural Stem Cells and Cancer Stem Cells -- 19. Markers of Stem Cells in Gliomas -- 20. Efficient Derivation and Propagation of Glioblastoma Stem-Like Cells Under Serum-Free Conditions Using the Cambridge Protocol -- 21. Glioma Cell Lines: Role of Cancer Stem Cells -- 22. Glioblastoma Cancer Stem Cells: Response to Epidermal Growth Factor Receptor Kinase Inhibitors -- Part IV. Therapy -- 23. Low- and High-Grade Gliomas: Extensive Surgical Resection -- 24. Brainstem Gangliogliomas: Total Resection and Close Follow-Up -- 25. Glioblastoma: Temozolomide-Based Chemotherapy -- 26. Drug-Resistant Glioma: Treatment with Imatinib Mesylate and Chlorimipramine -- 27. Glioblastoma Multiforme: Molecular Basis of Resistance to Erlotinib -- 28. Enhanced Glioma Chemosensitivity -- 29 Malignant Glioma Patients: Anti-Vascular Endothelial Growth Factor Monoclonal Antibody, Bevacizumab -- 30. Aggravating Endoplasmic Reticulum Stress by Combined Application of Bortezomib and Celecoxib as a Novel Therapeutic Strategy for Glioblastoma -- 31. Targeted Therapy for Malignant Gliomas -- 32. Glioblastomas: HER1/EGFR-Targeted Therapeutics -- 33. Epidermal Growth Factor Receptor Inhibition as a Therapeutic Strategy for Glioblastoma Multiforme -- 34. Role of Acyl-CoA Synthetases in Glioma Cell Survival and Its Therapeutic Implication -- 35. Malignant Glioma Patients: Combined Treatment with Radiation and Fotemustine -- 36. Malignant Glioma Immunotherapy: A Peptide Vaccine from Bench to Bedside -- 37. Malignant Glioma: Chemovirotherapy -- 38. Intracranial Glioma: Delivery of an Oncolytic Adenovirus -- 39. Use of Magnetic Resonance Spectroscopy Imaging (MRSI) in the Treatment Planning of Gliomas -- 40. Malignant Glioma Cells: Role of Trail-Induced Apoptosis -- Part V. Prognosis -- 41. Long-Term Survivors of Glioblastoma -- 42. Glioblastoma Patients: p15 Methylation as a Prognostic Factor.
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Tumors of the Central Nervous System. Vol. 2, Gliomas, Glioblastoma (Part 2)

https://libcat.nshealth.ca/en/permalink/provcat40904
edited by M.A. Hayat. --Dordrecht: Springer , c2011.
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Advantages and limitations of biomarkers in gliomagenesis are described. Molecular subtypes of gliomas are detailed. The role played by TP53 gene mutation in the deadliest brain tumor, glioblastoma multiforme, is pointed out. The role of mutations of IDH1 and IDH2, and isocitrate dehydrogenases in malignant gliomas are presented. Metabolic differences in different regions of the glioma tumor are clarified. Various types of imaging modalities, including PET and SPECT, to diagnose gliomas in gene…
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Other Authors
Hayat, M.A
Responsibility
edited by M.A. Hayat
Place of Publication
Dordrecht
Publisher
Springer
Date of Publication
c2011
Physical Description
1 online resource (xxi, 458 p.)
Series Vol.
v. 2
Series Title
Tumors of the central nervous system
ISBN
9789400706187
9789400706170 (print ed.)
Subjects (MeSH)
Antineoplastic Agents - therapeutic use
Biomarkers
Brain neoplasms - diagnosis
Brain neoplasms - therapy
Glioblastoma - diagnosis
Glioblastoma - therapy
Glioma - diagnosis
Glioma - therapy
Abstract
Advantages and limitations of biomarkers in gliomagenesis are described. Molecular subtypes of gliomas are detailed. The role played by TP53 gene mutation in the deadliest brain tumor, glioblastoma multiforme, is pointed out. The role of mutations of IDH1 and IDH2, and isocitrate dehydrogenases in malignant gliomas are presented. Metabolic differences in different regions of the glioma tumor are clarified. Various types of imaging modalities, including PET and SPECT, to diagnose gliomas in general and glioblastoma in particular in patients are explained in detail. Both low-grade and high-grade gliomas are discussed. Conventional as well as fluorescent-guided resection techniques for high-grade, recurrent malignant gliomas are detailed. Impact of resection extent on outcomes in patients with high-grade gliomas is clarified. The advantage of the use of intraoperative low-field MRI in glioma surgery is explained.
Contents
1. Introduction -- Part I. Biomarkers and Diagnosis -- 2. Gliomagenesis: Advantages and Limitations of Biomarkers -- 3. Molecular Subtypes of Gliomas -- 4. Glioblastoma: Germline Mutation of TP53 -- 5. Familial Gliomas: Role of TP53 Gene -- 6. The Role of IDH1 and IDH2 Mutations in Malignant Gliomas -- 7. Malignant Glioma: Isocitrate Dehydrogenases 1 and 2 Mutations -- 8. Metabolic Differences in Different Regions of Glioma Samples -- 9. Glioblastoma Patients: Role of Methylated MGMT -- 10. Brain Tumor Angiogenesis and Glioma Grading: Role of Tumor Blood Volume and Permeability Estimates Using Perfusion CT -- 11. Vasculogenic Mimicry in Glioma -- 12. Newly Diagnosed Glioma: Diagnosis Using Positron Emission Tomography with Methionine and Fluorothymidine -- 13. Role of Diffusion Tensor Imaging in Differentiation of Glioblastomas from Solitary Brain Metastases -- 14. 131I-TM-601 SPECT imaging of Human Glioma -- 15. Assessment of Biological Target Volume Using Positron Emission Tomography in High-Grade Glioma Patients -- 16. Skin Metastases of Glioblastoma -- Part II. Therapy -- 17. Diffuse Low-Grade Gliomas: What Does “Complete Resection” Mean? -- 18. Quantitative Approach of the Natural Course of Diffuse Low-Grade Gliomas -- 19. Impact of Extent of Resection on Outcomes in Patients with High-Grade Gliomas -- 20. Glioma Surgery: Intraoperative Low Field Magnetic Resonance Imaging -- 21. Low-Grade Gliomas: Intraoperative Electrical Stimulations -- 22. Malignant Gliomas: Present and Future Therapeutic Drugs -- 23. Recurrent Malignant Glioma Patients: Treatment with Conformal Radiotherapy and Systemic Therapy -- 24 Glioblastoma: Boron Neutron Capture Therapy -- 25. Glioblastoma: Anti-tumor Action of Cyclosporin A and Functionally Related Drugs -- 26. Glioblastoma Patients: Chemotherapy with Cisplatin, Temozolomide and Thalidomide -- 27. Glioblastoma: Role of Galectin-1 in Chemoresistance -- 28. Glioma-Initiating Cells: Interferon Treatment -- 29. Glioblastoma: Anti-tumor Action of Natural and Synthetic Cannabinoids -- 30. Patients with Recurrent High-Grade Glioma: Therapy with Combination of Bevacizumab and Irinotecan --- 31. Monitoring Gliomas In Vivo Using Diffusion-Weighted MRI During Gene Therapy-Induced Apoptosis -- 32. High-Grade Gliomas: Dendritic Cell Therapy -- 33. Glioblastoma Multiforme: Use of Adenoviral Vectors -- 34. Fischer/F98 Glioma Model: Methodology -- 35. Cellular and Molecular Characterization of Anti-VEGF and IL-6 Therapy in Experimental Glioma -- 36. Adult Brainstem Gliomas: Diagnosis and Treatment -- 37. The Use of Low Molecular Weight Heparin in the Treatment and Prevention of Thromboembolic Disease in Glioma Patients -- Part III. Prognosis -- 38. Brainstem Gliomas: An Overview -- 39. Tumor-Associated Epilepsy in Patients with Glioma -- 40. Brain Tumors Arising in the Setting of Chronic Epilepsy -- 41. Low-Grade Gliomas: Role of Relative Cerebral Blood Volume in Malignant Transformation -- 42. Angiocentric Glioma-Induced Seizures: Lesionectomy.
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Tumors of the Central Nervous system. Vol. 3, Brain Tumors (Part 1)

https://libcat.nshealth.ca/en/permalink/provcat40905
edited by M.A. Hayat. --Dordrecht: Springer , c2011.
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The classification of brain tumors is up-dated using magnetic resonance spectroscopy technology. The role of cellular immortality in brain tumors is reviewed. Tumor to tumor metastases are a common occurrence; for example, brain metastasis from breast cancer, lung cancer, and renal cancer is discussed. Genetic profiling and treatment (including neurosurgery) of such brain cancers are explained. Breast cancer patients treated with certain drugs (e.g., capecitabine and lapatinib can develop CNS t…
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Other Authors
Hayat, M.A
Responsibility
edited by M.A. Hayat
Place of Publication
Dordrecht
Publisher
Springer
Date of Publication
c2011
Physical Description
1 online resource (xxii, 382 p.)
Series Title
Tumors of the central nervous system
ISBN
9789400713994
9789400713987 (print ed.)
Subjects (MeSH)
Brain neoplasms
Abstract
The classification of brain tumors is up-dated using magnetic resonance spectroscopy technology. The role of cellular immortality in brain tumors is reviewed. Tumor to tumor metastases are a common occurrence; for example, brain metastasis from breast cancer, lung cancer, and renal cancer is discussed. Genetic profiling and treatment (including neurosurgery) of such brain cancers are explained. Breast cancer patients treated with certain drugs (e.g., capecitabine and lapatinib can develop CNS tumors. Role of brain tumor suppressor genes (e.g., NRP/B gene) is pointed out. Biomarkers used to diagnose brain malignancies are explained in detail. A number of imaging modalities used for diagnosing and assessing the effectiveness of treatments of brain tumors are presented. The imaging methods discussed include MRI, PET, CT, MRSi, and SPECT. Also, is discussed the impact of PET using radiolabeled amino acids on brain tumors.
Contents
1. Introduction -- 2. Brain tumor classification using magnetic resonance spectroscopy -- 3. Cellular immortality in brain tumors: an overview -- Part I. Tumor to tumor passage of malignancy -- 4. Tumor-to-tumor metastases: extracranial tumor metastasis to intracranial tumors -- 5. Brain metastases from breast cancer: treatment and prognosis -- 6. Brain metastasis in renal cell carcinoma patients -- 7. Coexistance of inflammatory myofibroblastic tumors in the lung and brain -- 8. Breast cancer and renal cell cancer metastases to the brain -- 9. Brain metastases from breast cancer: genetic profiling and neurosurgical therapy -- 10. Central nervous system tumors in women who received capectiabine and lapatinib therapy for metastatic breast cancer -- Part II. Biomarkers and diagnosis -- 11. Functional role of the novel nrp/b tumor suppressor gene -- 12. Brain tumors: diagnostic impact of pet using radiolabelled amino acids -- 13. Malignant peripheral nerve sheath tumors: use of 18fdg-pet/ct -- 14. Brain tumors: evaluation of perfusion using 3d-fse-pseudo-continous arterial spin labeling -- 15. Cerebral cavernous malformations: advanced magnetic resonance imaging --- 16. Nosologic imaging of brain tumors using mri and mrsi -- 17. Brain tumor diagnosis using pet with angiogenic vessel-targeting liposomes -- 18. Frozen section evaluation of central nervous system lesions -- 19. Clinical role of micrornas in different brain tumors -- Part III. Therapy -- 20. Electrochemotherapy for primary and secondary brain tumors -- 21. Brain tumors: convection-enhanced delivery of drugs (method) -- 22. Brain metastases: clinical outcomes for stereotactic radiosurgery (method) -- 23. Noninvasive treatment for brain tumors: magnetic resonance guided focused ultrasound surgery -- 24. Radioguided surgery of brain tumors -- 25. Implications of mutant epidermal growth factor variant III in brain tumor development and novel targeted therapies -- 26. Endoscopic port surgery for intraparenchymal brain tumors -- 27. Intracranial tumor surgery in the elderly patients -- 28. Intracranial hemangiopericytoma: gamma knife surgery -- 29. Stereotactic radiosurgery for cerebral metastasis of digestive tract tumors -- 30. Malignant brain tumors: role of radioresponsive gene therapy -- Part IV. Prognosis -- 31. Brain tumors: quality of life -- 32. Health related quality of life in patients with high-grage gliomas -- 33. Epilepsy and brain tumors and antiepileptic drugs -- 34. Familial caregivers of patients with brain cancer -- 35. Pain management following craniotomy -- 36. Air transportation of patients with brain tumors.
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Tumors of the Central Nervous System. Vol. 6, Spinal Tumors (Part 1)

https://libcat.nshealth.ca/en/permalink/provcat31280
edited by M.A. Hayat. --Dordrecht: Springer , c2012.
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With tens of thousands of new CNS tumor cases each year in the US alone, this Book Series is a vital resource for any medical professional encountering brain and CNS neoplasms in their work. Their frequent occurrence, as well as the scope and pace of research in the field, make staying on top of developments a priority. Focusing on the diagnosis, therapy and prognosis of those affecting the spine, this sixth volume in the series on tumors in the human central nervous system covers the key aspec…
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Other Authors
Hayat, M.A
Responsibility
edited by M.A. Hayat
Alternate Title
Spinal Tumors
Place of Publication
Dordrecht
Publisher
Springer
Date of Publication
c2012
Physical Description
1 online resource (xxx, 241 p. : 64 ill., 26 ill. in color)
Series Vol.
v. 6, pt. 1
Series Title
Tumors of the central nervous system
ISBN
9789400728660
Subjects (MeSH)
Central Nervous System Neoplasms
Spinal Cord Neoplasms
Subjects (LCSH)
Oncology
Neurology
Radiology, Medical
Surgery
Abstract
With tens of thousands of new CNS tumor cases each year in the US alone, this Book Series is a vital resource for any medical professional encountering brain and CNS neoplasms in their work. Their frequent occurrence, as well as the scope and pace of research in the field, make staying on top of developments a priority. Focusing on the diagnosis, therapy and prognosis of those affecting the spine, this sixth volume in the series on tumors in the human central nervous system covers the key aspects of a range of major spinal tumors, including astrocytomas, ependymomas, and oligodendroglioma. It provides readers with insights into the molecular pathways involved in tumor biology as well as a detailed classification of intradural spinal tumors that includes figures on the relative incidence of the three major types. Moving on to oligodendroglioma and primary spinal cord tumors, the volume discusses their diagnoses, outcomes and prognoses, before explaining procedures for identifying other spinal tumor varieties such as pilomyxoid and chordomas. Contributors also enumerate the benefits of neuroimaging in assessing spinal teratoid/rhabdoid and gangliogliomas neoplasms, and present detailed guides to treating a number of tumors affecting the spinal cord. The comprehensive coverage includes discussion of therapies across the spectrum of medical intervention, from chemotherapy and surgery to cyberknife stereotactic radiotherapy and rhenium-186 intracavity radiation. With assessments of the utility of transplanting stem-cell progenitors in repairing injured spinal cord, and explanations of new diagnostic and therapeutic technology, this volume of the TCNS series is as inclusive as it is informative.
Contents
[Machine generated contents note] Pt. I Introduction -- 1. General Introduction / M.A. Eric Hayat -- 2. Pediatric Mixed Glioneuronal Tumors in the Spinal Cord / Ravi Raghavan -- 3. Intradural Spinal Tumors: Classification, Symptoms, and Radiological Features / Pia C. Sundgren -- 4. Non-Dysraphic Intradural Spinal Cord Lipoma: Management Guidelines / Adrian T.H. Casey -- 5. Malignant Astrocytomas of the Spinal Cord: Clinicopathologic Parameters / Elisabeth J. Rushing -- 6. Spinal Epidural Angiolipoma / Sebastien Lepreux -- Pt. II Diagnosis -- 7. Spinal Cord Tumor Oligodendroglioma: Diagnosis / Metin Ozdemirli -- 8. Primary Spinal Oligodendroglioma: Diagnosis, Outcome, and Prognosis / Eftychia Z. Kapsalaki -- 9. Pilomyxoid Astrocytoma of the Spinal Cord with Cerebrospinal Fluid and Peritoneal Metastasis / Thierry A.G.M. Huisman -- 10. Intraspinal Oncocytic Adrenocortical Adenoma: Diagnosis / Jens Schittenhelm -- 11. Chordomas of the Clivus and Upper Cervical Spine / David Choi -- Pt. III Imaging -- 12. Spinal Teratoid/Rhabdoid Tumor: Use of Diffusion - Weighted Imaging for Diagnosis / Taro Takahara -- 13. Gangliogliomas of the Spinal Cord: Neuroimaging Correlations with Pathology, Controversies in Pathological Diagnosis, and Prognosis / Douglas C. Miller -- Pt. IV Therapy -- 14. Surgery for Spinal Tumours / Marios C. Papadopoulos -- 15. Resection of Spinal Meningioma: Postoperative Focal Hyperemia / Yoshinobu Iwasaki -- 16. Spinal Cord Hemangioblastomas: Surgical Management / Russell R. Lonser -- 17. Spinal Radiosurgery: Delayed Radiation-Induced Myelopathy / Iris C. Gibbs -- 18. Metastatic Spine Disease: Indications, Timing, and Outcomes for Surgery and Radiation Therapy / Charles G. Fisher -- 19. Sequence of Surgery, Radiotherapy, and Stereotactic Radiosurgery in the Treatment of Metastatic Spine Disease: Effects on Wound Healing / Charles G. Fisher -- 20. Treatment of Spinal Tumors with Cyberknife Stereotactic Radiotherapy / Scott G. Soltys -- 21. Recurrent Spinal Cord Cystic Astrocytomas: Treatment with Rhenium-186 Intracavitary Radiation / Jean-Claude Marchal -- 22. Embolization of Spinal Tumors / Mohammad Ali Aziz-Sultan -- 23. Embolization of Spinal Cord Tumours / Sorin Aldea -- 24. Locomotor Recovery After Spinal Cord Transection: Transplantation of Oligodendrocytes and Motoneuron Progenitors Generated from Human Embryonic Stem Cells / Miodrag Stojkovic -- 25. Malignant Primary Spinal Neoplasms: Total En Bloc Spondylectomy / Alexander Taghva.
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Tumors of the Central Nervous System. Vol. 7, Meningiomas and Schwannomas

https://libcat.nshealth.ca/en/permalink/provcat31281
edited by M.A. Hayat. --Dordrecht: Springer , c2012.
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This seventh volume of the essential series covering practices and developments relating to CNS tumors zeroes in on those found in the brain. Detailed dossiers on meningioma and schwannoma tumors cover aspects including diagnosis, therapy and prognosis. The text delivers vital insights into the molecular pathways related to brain tumor biology, including a detailed analysis of the roles played in neoplasm formation by E-cadherin gene instability, carbonic anhydrase 11, urokinase plasminogen act…
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Hayat, M.A
Responsibility
edited by M.A. Hayat
Alternate Title
Meningiomas and Schwannomas
Place of Publication
Dordrecht
Publisher
Springer
Date of Publication
c2012
Physical Description
1 online resource (xxxv, 359 p. : 67 ill., 35 ill. in color)
Series Vol.
v. 7
Series Title
Tumors of the central nervous system
ISBN
9789400728943
Subjects (MeSH)
Brain neoplasms
Central Nervous System Neoplasms
Meningioma
Neurilemmoma
Subjects (LCSH)
Oncology
Neurosciences
Radiology, Medical
Abstract
This seventh volume of the essential series covering practices and developments relating to CNS tumors zeroes in on those found in the brain. Detailed dossiers on meningioma and schwannoma tumors cover aspects including diagnosis, therapy and prognosis. The text delivers vital insights into the molecular pathways related to brain tumor biology, including a detailed analysis of the roles played in neoplasm formation by E-cadherin gene instability, carbonic anhydrase 11, urokinase plasminogen activator, and Wnt signaling. Further research into their influence in the process could prompt the development of effective anti-cancer drugs. The contributions also show how perfusion magnetic resonance imaging helps physicians differentiate between subtypes of meningiomas, and analyze the influence of molecular genetics and epigenetic mechanisms on schwannoma tumors. Among the diagnostic processes outlined are those for recognizing incidentally discovered meningioma, cystic papillary meningioma, facial nerve schwannoma, vestibular schwannoma, and intermediate nerve schwannoma. This book presents treatments for atypical, oncocytic, intracranial, and cavernous meningiomas, as well as guides to therapeutic methods ranging from neurosurgery and gamma-knife radiosurgery to vestibular schwannoma interventions such as retrosigmoidal craniotomy and immunotherapy. This authoritative volume once again provides invaluable and tightly focused source material for medical professionals committed to placing the latest theories and techniques at the service of those they care for.
Contents
[Machine generated contents note] Meningiomas -- Pt. I Molecular Genetics -- 1. Meningiomas: Role of Semaphorin3A Protein in Antiangiogenesis / Valeria Barresi -- 2. Meningiomas: Role of Carbonic Anhydrase II / Silvia Pastorekova -- 3. Meningiomas: Role of Genetic Instabilities of the E-cadherin Gene / Nives Pecina-Slaus -- 4. Intracranial Meningiomas: Role of Exogenous Hormones / Michael Schulder -- 5. Meningiomas: Clinical Needs and Molecular Insights / Connie Jimenez -- 6. Meningioma: Urokinase Plasminogen Activator / Jasti S. Rao -- 7. miR-200a Regulation of the Wnt Signaling in Meningioma Tumorigenesis / Okay Saydam -- Pt. II Diagnosis -- 8. Meningiomas: Determination of Subtypes Using Perfusion Magnetic Resonance Imaging / Matthijs Oudkerk -- 9. Intracranial Meningioma in Mice: Noninvasive Bioluminescence Imaging / Randy L. Jensen -- 10. Incidentally Discovered Meningiomas: Growth Rates and Patterns / Toshiki Yoshimine -- 11. Cystic Papillary Meningioma: Diagnosis / Yang Li -- 12. Meningioma Tumors: Detection of Subgroups / Miguel Cerda-Nicolas -- 13. Prognostic Parameters in Atypical and Malignant Meningiomas / Mara Popovic -- 14. Sporadic Meningioangiomatosis: Diagnosis with Computed Tomography and Magnetic Resonance Imaging / Lei Huang -- Pt. III Therapy -- 15. Atypical Meningioma: Distinguishing Features and Role of Adjuvant Radiation / Manish K. Aghi -- 16. Gamma Knife Radiosurgery for Benign Meningioma: Significance and Therapeutic Potential / Frank Unger -- 17. Oncocytic Meningioma: Neurosurgery / Elena Zunarelli -- 18. Intracranial Meningiomas: Treatment and Quality of Life / Jurgen Meixensberger -- 19. Cavernous Sinus Meningiomas: Optimal Treatment / Roberto Delfini -- Pt. IV Recurrence -- 20. Genetic and Clinical Features Associated with Recurrence in Atypical Meningioma / Yvonne W. Lui -- 21. Recurrence and Progression in Meningiomas / Steffi Urbschat -- 22. Meningioma: Role of Erythropoietin Receptor in the Tumor Recurrence / Onno Kuster -- Schwannomas -- Pt. V Molecular Genetics -- 23. Cyclin D1 Expression in Vestibular Schwannoma / Juan A. Rey -- 24. Schwannomas: Role of Molecular Genetics and Epigenetic Mechanisms / Juan A. Rey -- Pt. VI Diagnosis -- 25. Facial Nerve Schwannoma: Diagnosis Using Magnetic Resonance Imaging / Kevin J. Gibbons -- 26. Vestibular Schwannoma: Optimizing Tumor Growth Monitoring by Volume Measurements / Robert J. Stokroos -- 27. Intermediate Nerve Schwannomas / Christian Strauss -- Pt. VII Therapy -- 28. Vestibular Schwannoma, Radiosurgery and Hydrocephalus / Keith A. Cauley -- 29. Solitary Vestibular Schwannoma: Decision Making of Treatments / Alessandro De Stefano -- 30. Stereotactic Radiosurgery for Trigeminal Schwannoma: Tumor Control and Functional Preservation / L. Dade Lunsford -- 31. Vestibular Schwannoma: Gamma Knife Radiosurgery / Dong Gyu Kim -- 32. Vestibular Schwannoma: Gamma Knife Radiosurgery (Method) / Christopher M. Lee -- 33. Vestibular Schwannoma Surgery: Use of Fat Implant to Prevent Cerebrospinal Fluid Fistula / Wolf Olaf Ludemann -- 34. Retrosigmoidal Craniotomy for Vestibular Schwannoma Patients: Postoperative Cerebrospinal Fluid Leak / Madjid Samii -- 35. Vestibular Schwannoma (VS) Surgery: Histological Considerations and Operative Results / Suzuki O. Satoshi -- 36. Vestibular Schwannomas: Treatment with Bevacizumab / Ricardo J. Komotar -- 37. Management of Vestibular Schwannoma Patients: Quality of Life Outcomes After Treatment / Ryojo Akagami.
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Tumors of the Central Nervous System. Vol. 8, Astrocytoma, Medulloblastoma, Retinoblastoma, Chordoma, Craniopharyngioma, Oligodendroglioma, and Ependymoma

https://libcat.nshealth.ca/en/permalink/provcat31282
edited by M.A. Hayat. --Dordrecht: Springer , c2012.
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With tens of thousands of new CNS tumor cases each year in the US alone, this series of publications is a valuable aid to the diagnosis and treatment of these problematic neoplasms. Now, the eighth in the set returns to the topic of brain tumors, dealing with seven distinct types: astrocytoma, medulloblastoma, retinoblastoma, chordoma, craniopharyngioma, oligodendroglioma, and ependymoma. After updating the classification of medulloblastoma the volume provides an overview of ependymoma as well …
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Hayat, M.A
Responsibility
edited by M.A. Hayat
Alternate Title
Astrocytoma, Medulloblastoma, Retinoblastoma, Chordoma, Craniopharyngioma, Oligodendroglioma, and Ependymoma
Place of Publication
Dordrecht
Publisher
Springer
Date of Publication
c2012
Physical Description
1 online resource (xxxvii, 338 p. : 50 ill., 38 ill. in color)
Series Vol.
v. 8
Series Title
Tumors of the central nervous system
ISBN
9789400742130
Subjects (MeSH)
Brain neoplasms
Central Nervous System Neoplasms
Neuroectodermal Tumors
Subjects (LCSH)
Oncology
Neurosciences
Abstract
With tens of thousands of new CNS tumor cases each year in the US alone, this series of publications is a valuable aid to the diagnosis and treatment of these problematic neoplasms. Now, the eighth in the set returns to the topic of brain tumors, dealing with seven distinct types: astrocytoma, medulloblastoma, retinoblastoma, chordoma, craniopharyngioma, oligodendroglioma, and ependymoma. After updating the classification of medulloblastoma the volume provides an overview of ependymoma as well as describing the delineation of prognosis based on the genetic aberrations of the latter patients. The material offers key insights into the molecular pathways involved in tumor biology, such as the role of E-cadherin gene instability, carbonic anhydrase II, urokinase plasminogen activator, and Wnt signaling in meningioma. Contributors explain the genetic and clinical features associated with recurring meningioma, including the role played by erythropoietin receptor, and examine the way in which OTX2 transcription factor functions as an oncogene in medulloblastoma. With much more besides, including discussion of the molecular mechanisms that result in resistance to chemotherapy in medulloblastoma, this volume and its companions have a positive role to play in inspiring a new generation of researchers to design new drugs that are better targeted'and thus more effective.
Contents
[Machine generated contents note] Pt. I Astrocytoma -- 1. Astrocytoma Cell Line: Role of Brain Natriuretic Peptide / Ken Okumura -- 2. Malignant Brain Astrocytomas: Extent of Resection Affects Survival / Matthew J. McGirt -- Pt. II Medulloblastoma -- 3. Medulloblastoma: Classification (A Review) / Antonio Giordano -- 4. Medulloblastomas: Clinically Important MicroRNA Genes / Deepak Kamnasaran -- 5. Medulloblastoma: Role of OTX2 Transcription Factors / D. Cory Adamson -- 6. Molecular Mechanisms of Chemoresistance in Medulloblastoma / Daniel Meley -- 7. Extraneural Metastasis in Medulloblastoma / Arnold C. Paulino -- 8. Medulloblastoma: Therapy with Bortezomib/Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand / Heidrun Holland -- 9. Standard-Risk Medulloblastoma: Hyperfractionated Radiotherapy / Marie-Pierre Sunyach -- Pt. III Retinoblastoma -- 10. Retinoma and Retinoblastoma: Genomic Hybridisation / Alessandra Renieri -- 11. Cell Cycle Control by Ataxia Telangiectasia Mutated Protein Through Regulating Retinoblastoma Protein Phosphorylation / Jaume Folch -- 12. Role of Survivin in Retinoblastoma: Diagnosis and Prognosis / Eman Elsayed -- 13. Retinoblastoma Epigenetics / Giovanni Grasso -- 14. Retinoblastoma: Disease, Diagnosis, Therapy and Management / Vikas Khetan -- 15. Long-Term Survivors of Retinoblastoma: Risk of Increased Second Malignancy / Flora E. van Leeuwen -- 16. New Cancers Among Long-Term Survivors of Retinoblastoma / Alessandro Franchi -- Pt. IV Chordoma -- 17. Chordoma: Role of CAM5.2 / Takahiko Naka -- 18. Chordomas and Chondrosarcomas: Treatment with Particle Radiotherapy / Daniela Schulz-Ertner -- 19. Skull Base Chordomas: Endonasal Endoscopic Transclival Approach / Theodore H. Schwartz -- Pt. V Craniopharyngioma -- 20. Craniopharyngioma: Comparison Between Supra-orbital Versus Endonasal Keyhole Approaches / Daniel F. Kelly -- 21. Expanded Endoscopic Endonasal Approach for Primary and Recurrent Craniopharyngiomas / Amin B. Kassam -- 22. Craniopharyngioma: The Role of Radiation / Martin Pavelic -- 23. Cystic Craniopharyngiomas: Intratumoral Bleomycin Therapy / Juliette Hukin -- Pt. VI Oligodendroglioma -- 24. Anaplastic Oligodendroglioma Metastasized to Extraneural Sites / Mara Popovic -- 25. Recurrent Oligodendroglioma: Treatment with Bevacizumab / Marc C. Chamberlain -- Pt. VII Ependymoma -- 26. Ependymoma: An Overview / Paul Graham Fisher -- 27. Ependymomas: Prognosis Based on Genetic Aberrations / Gentner Doreen -- 28. Aberrant DNA Methylation in Ependymomas / Hehuang Xie -- 29. Progressively Metastasizing Ependymoma: Genomic Aberrations / Till Milde -- 30. Extradural Ependymoma: Diagnosis Using Magnetic Resonance Imaging / Roberto Pallini -- 31. Primary Malignant Ependymoma of the Abdominal Cavity: Diagnosis / Wolf Mueller -- 32. Atypical Histologic Features and Patterns of Malignant Evolution in Tanycytic Ependymoma / Ekkehard Hewer -- 33. Intracranial Ependymoma: Role for Chemotherapy / Marc C. Chamberlain.
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Tumors of the Central Nervous System. Vol. 9, Lymphoma, Supratentorial Tumors, Glioneuronal Tumors, Gangliogliomas, Neuroblastoma in Adults, Astrocytomas, Ependymomas, Hemangiomas, and Craniopharyngiomas

https://libcat.nshealth.ca/en/permalink/provcat31286
edited by M.A. Hayat. --Dordrecht: Springer , c2012.
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The ninth volume in this essential series discusses key advances in our understanding of neoplasms in the human central nervous system. This publication deals with various aspects of nine separate types of brain tumors. With 70 contributors from 17 nations, this edition offers an unrivalled thoroughness and breadth of coverage that includes the very latest research results on the following tumor types: astrocytoma, lymphoma, supratentorial and glioneuronal tumors, gangliogliomas, neuroblastoma …
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Hayat, M.A
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edited by M.A. Hayat
Alternate Title
Lymphoma, Supratentorial Tumors, Glioneuronal Tumors, Gangliogliomas, Neuroblastoma in Adults, Astrocytomas, Ependymomas, Hemangiomas, and Craniopharyngiomas
Place of Publication
Dordrecht
Publisher
Springer
Date of Publication
c2012
Physical Description
1 online resource (xl, 296 p. : 46 ill., 25 ill. in color)
Series Vol.
v. 9
Series Title
Tumors of the central nervous system
ISBN
9789400754881
Subjects (MeSH)
Brain neoplasms
Central Nervous System Neoplasms
Subjects (LCSH)
Oncology
Neurology
Abstract
The ninth volume in this essential series discusses key advances in our understanding of neoplasms in the human central nervous system. This publication deals with various aspects of nine separate types of brain tumors. With 70 contributors from 17 nations, this edition offers an unrivalled thoroughness and breadth of coverage that includes the very latest research results on the following tumor types: astrocytoma, lymphoma, supratentorial and glioneuronal tumors, gangliogliomas, neuroblastoma in adults, hemangioma, and ependymoma. The content introduces new technologies and their applications in diagnosis, treatment and therapy of tumors. It explains molecular profiling techniques that enable oncologists to select appropriate therapies for clinical trials, and discusses a number of surgical treatments, including resection and radiosurgery. Volume 9 is interspersed with color illustrations and tables depicting many of the results. This volume joins its fellow publications in a valuable series that fully explores controversies and debates in CNS cancer therapy, and furthers the scientific quest for effective therapies to combat cancer in all its forms.
Contents
[Machine generated contents note] Pt. I Lymphoma -- 1. Neurolymphomatosis: Diagnosis, Treatment, and Outcome / Tali Siegal -- 2. Primary Central Nervous System Lymphoma: Systemic Relapse / Herve Ghesquieres -- 3. Central Nervous System Recurrence in the Primary Mediastinal Large B-Cell Lymphoma: Treatment / Koichi Sugimoto -- 4. Primary Central Nervous System Lymphoma Resulting in Stroke and Leukoencephalopathy / Johann Willeit -- 5. Primary CNS Lymphoma: Immunohistochemistry of BCL-6 and Treatment with High-Dose Methotrexate / Hiroyuki Momota -- 6. Thiamine Deficiency Complicating the Treatment of Primary CNS Lymphoma / Christopher McNamara -- 7. Metastatic Brain Irradiation-Induced Lymphocytosis Predicts Efficacy of Radiotherapy / Paolo Lissoni -- 8. Primary Central Nervous System Lymphoma: Treatment with High-Dose Methotrexate / Markus Joerger -- 9. Paraneoplastic Syndromes in Primary CNS Lymphoma / Ali Bazarbachi -- Pt. II Supratentorial Tumors -- 10. Supratentorial Primitive Neuroectodermal Tumor: Biology / Barry Pizer -- 11. Outpatient Brain Biopsy and Craniotomy for Supratentorial Tumor / Mark Bernstein -- 12. Wrong-Site Craniotomy Prevention / Mark Bernstein -- Pt. III Glioneuronal Tumors -- 13. Diffuse Leptomeningeal Glioneuronal Tumors: Histology. Is It a New Entity? / Matteo Fassan -- 14. Temporomesial Glioneuronal Tumors: Epilepsy Surgery / Fabio Calbucci -- 15. Rosette-Forming Glioneuronal Tumor: Conservative Management Strategy / Caroline C. Tan -- Pt. IV Gangliogliomas -- 16. Ganglioneuroma: An Overview / Cihangir Erem -- 17. Ganglioglioma, mTOR Activation, and Epileptogenesis / Peter B. Crino -- 18. Gangliogliomas and Other Low Grade Neuronal Neoplasms of the Central Nervous System: Diagnosis, Treatment, and Prognosis / Wayne C. Paullus -- Pt. V Neuroblastoma in Adults -- 19. Adult Neuroblastoma Diagnosis / Rishi Kumar -- 20. Proliferation of Neuroblasts in the Adult Brain: Role of Diversin / Kazunobu Sawamoto -- Pt. VI Astrocytomas and Ependymomas -- 21. Subependymal Giant Cell Astrocytoma: Treatment / Cynthia J. Campen -- 22. Acquired Retinal Astrocytoma / Daniel Vilaplana -- 23. Presence of Both Ependymoma and Astrocytoma in the Same Patient: Diagnosis / Gordan Grahovac -- Pt. VII Hemangiomas -- 24. Total Removal of Cavernous Hemangioma Using the Tonsillouveal Transaqueductal Approach (Method) / Ali F. Krisht -- 25. Cavernous Sinus Hemangiomas Treated with Gamma Knife Surgery / Kang-Du Liu -- 26. Linear Accelerator Radiosurgery for Cavernous Malformation / Peng-Wei Hsu -- 27. Treatment of Brainstem Hemangioblastomas / Russell R. Lonser -- Pt. VIII Craniopharyngiomas -- 28. Craniopharyngiomas: An Overview / Niki Karavitaki -- 29. Radical Removal of Craniopharyngiomas / Filippo Gagliardi -- Pt. IX Neurogenesis -- 30. Neurogenesis Outside the Central Nervous System (An Overview) / Paola Crociara -- 31. Neurogenesis and Reproduction / Kwok-Fai So.
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Tumors of the Central Nervous System. Vol. 10, Pineal, Pituitary, and Spinal Tumors

https://libcat.nshealth.ca/en/permalink/provcat32539
edited by M.A. Hayat. --Dordrecht: Springer , c2013.
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Adding to a vitally important cycle of publications covering the latest research developments in our understanding of neoplasms affecting the human central nervous system, this edition focuses on numerous aspects of pineal, pituitary, and spinal tumors. As with the previous volumes in the series, this latest work addresses a central imperative in cancer research'the need to standardize classifications, written definitions and investigative guidelines in order to achieve a measure of shared obje…
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Other Authors
Hayat, M.A
Responsibility
edited by M.A. Hayat
Alternate Title
Pineal, Pituitary, and Spinal Tumors
Place of Publication
Dordrecht
Publisher
Springer
Date of Publication
c2013
Physical Description
1 online resource (xliv, 349 p. : 70 ill., 46 ill. in color)
Series Vol.
v. 10
Series Title
Tumors of the central nervous system
ISBN
9789400756816
Subjects (MeSH)
Brain neoplasms
Central Nervous System Neoplasms
Pineal Gland
Pinealoma
Pituitary Neoplasms
Spinal Cord Neoplasms
Subjects (LCSH)
Oncology
Neurology
Abstract
Adding to a vitally important cycle of publications covering the latest research developments in our understanding of neoplasms affecting the human central nervous system, this edition focuses on numerous aspects of pineal, pituitary, and spinal tumors. As with the previous volumes in the series, this latest work addresses a central imperative in cancer research'the need to standardize classifications, written definitions and investigative guidelines in order to achieve a measure of shared objectivity among academics engaged in one of the most important medical endeavors of our era. It brings together the very latest work by oncologists, neurosurgeons, physicians, research scientists, and pathologists, providing the medical community with a wealth of data and results that, taken together, will advance the cause of cancer research. The volume synthesizes work on diagnosis, drug development, and therapeutic approaches that are typically scattered in a variety of journals and books. It features promising recent work in applying molecular genetics to clinical practice and evidence-based therapy, covering molecular profiling of tumors as well as a number of surgical treatments such as resection and radiosurgery. Together with its counterpart publications, it represents a much-needed central resource that will inform and guide future research efforts.
Contents
Preface. Pt. I. Pineal tumors -- Papillary tumor of the pineal region -- Pineal region tumors: clinical aspects -- Papillary tumor of the pineal region: diagnosis -- Pineal parenchymal tumors: immunohhistochemistry -- Pineal parenchymal tumors: diagnostics and prognosis -- Papillary tumors of the pineal region: diagnosis and treatment -- Pineal region tumors: optimal neurosurgical treatment. Pt. II. Pituitary tumors -- Pituitary tumors: genetics and heritable predisposition -- Xanthogranulomas associated with pituitary adenomas: magnetic resonance imaging -- Pituitary adenoma and craniopharyngioma: an overview -- Familial pituitary adenomas: an overview -- Papillary glioneuronal tumor -- Solitary fibrous tumor -- Pituitary adenomas: mcm2 protein as a cell proliferation marker -- Pituitary adenomas: role of cyclin-dependent kinase inhibitors -- Pituitary tumorigenesis: role of regulation of wee1 kinase by micrornas -- Pituitary tumor cells: role of pkc, pkcþ, and pck¢ expression -- Pituitary adenoma: role of hmga proteins -- Pituitary adenomas: role of e-cadherin in tumor invasion -- Pituitary tumorigenesis: role of the wnt signaling pathway -- The role of aryl hydrocarbon receptor (ahr) and ahr-interacting Protein (aip) in the pathogenesis of pituitary adenomas -- Pituitary tumors: role of pituitary tumor- transforming gene-1 (pttg1) -- Pituitary adenomas: endoscopic endonasal transphenoidal Technique -- Pituitary adenoma patients: hypofractionated cyberknife Radiosurgery (method) -- Transspheniodal/transcranial surgery of pituitary adenomas: Prognosis-related occurrence for the trigemino-cardiac reflex. Pt. III. Spinal tumors -- Spinal extradural meningiomas -- Spinal cord ganglio glioma -- Spinal angiolipoma: diagnosis and treatment -- Spinal cord injury: tissue engineering using neural stem cells -- Pediatric spinal tumors: total removal using laminotomy -- Treatment of metastatic spinal epidural disease: surgery versus radiotherapy -- Metastatic spinal cord compression from synovial sarcoma: surgical resection -- Adult spinal intramedullary ependymomas: complete resection -- Spinal intramedullary astrocytomas: prognostic factors.
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Tumors of the Central Nervous System. Volume 4, Brain Tumors (Part 2)

https://libcat.nshealth.ca/en/permalink/provcat40878
edited by M.A. Hayat. --Dordrecht: Springer , c2012.
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This volume mainly contains information on the diagnosis, therapy, and prognosis of brain tumors. Insights on the understanding of molecular pathways involved in tumor biology are explained, which should lead to the development of effective drugs. Information on pathways (e.g., hedgehog) facilitates targeted therapies in cancer. Tumor models are also presented, which utilize expression data, pathway sensitivity, and genetic abnormalities, representing targets in cancer. For example, rat model o…
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Hayat, M.A
Responsibility
edited by M.A. Hayat
Alternate Title
Brain tumors
Place of Publication
Dordrecht
Publisher
Springer
Date of Publication
c2012
Physical Description
1 online resource (xxvi, 386 p. : ill.)
Series Vol.
v. 4
Series Title
Tumors of the central nervous system
ISBN
9789400717060
9789400717053 (print ed.)
Subjects (MeSH)
Brain neoplasms
Abstract
This volume mainly contains information on the diagnosis, therapy, and prognosis of brain tumors. Insights on the understanding of molecular pathways involved in tumor biology are explained, which should lead to the development of effective drugs. Information on pathways (e.g., hedgehog) facilitates targeted therapies in cancer. Tumor models are also presented, which utilize expression data, pathway sensitivity, and genetic abnormalities, representing targets in cancer. For example, rat model of malignant brain tumors using implantation of doxorubicin with drug eluting beads for delivery is explained. The future of pathway-driven therapies for tumors is summarized. The importance of personalizing cancer care is emphasized. The need for supportive measures for survivors of brain cancer is pointed out, so is the quality of life monitoring. The need of rehabilitation therapy for patients with primary and metastatic brain tumors is also emphasized. Role of MicroRNA in distinguishing primary tumors from metastatic primary tumors is discussed. Advantages and limitations of chemotherapy (e.g., temozolomide and doxorubicin) are discussed. The complexity of tumor to tumor transfer is explained; examples discussed are: brain metastases from breast cancer and brain metastases fro non-small cell lung carcinoma. Identification and characterization of biomarkers, including those for metastatic brain tumors, are presented. Genomic analysis for identifying clinically relevant subtypes of glioblastoma is included. A large number of imaging modalities are detailed to study progression and invasion of gliomas.
Contents
Part I. Introduction -- 1. Epidemiology of Primary Brain Tumors -- 2. Supratentorial Primitive Neuroectodermal Tumors -- 3. Epileptic Seizures and Supratentorial Brain Tumors in Children -- Part II. Tumor to Tumor -- 4. Breast Cancer Metastasis to the Central Nervous System -- 5. Melanoma to Brain Metastasis: Photoacoustic Microscopy -- Part III. Biomarkers and Diagnosis -- 6. Extraaxial Brain Tumors: The Role of Genetic Polymorphisms -- 7. Central Nervous System Germ Cell Tumor -- 8. Microvascular Gene Changes in Malignant Brain Tumors -- 9. Role of MicroRNA in Glioma -- 10. Glioblastoma Multiforme: Cryopreservation of Brain Tumor-Initiating Cells (Method) -- 11. Relationship Between Molecular Oncology and Radiotherapy in Malignant Gliomas (An Overview) -- 12. High-Grade Brain Tumours: Evaluation of New Brain Lesions by Amino Acid PET -- 13. Cyclic AMP Phosphodiesterase-4 in Brain Tumor Biology: Immunochemical Analysis -- Part IV. Imaging -- 14. Molecular Imaging of Brain Tumours Using Single Domain Antibodies -- 15. Quantitative Analysis of Pyramidal Tracts in Brain Tumor Patients Using Diffusion Tensor Imaging -- 16. Differentiation Between Gliomatosis Cerebri and Low-Grade Glioma: Proton Magnetic Resonance Spectroscopy -- 17. Peripheral Nerve Sheath Tumors: Diagnosis Using Quantitative FDG-PET -- 18. Tumor Resection Control Using Intraoperative Magnetic Resonance Imaging -- 19. Brain Tumors: Clinical Applications of Functional Magnetic Resonance Imaging and Diffusion Tensor Imaging -- 20. Trigeminal Neuralgia: Diagnosis Using 3-D Magnetic Resonance Multi-Fusion Imaging -- 21. Epilepsy-Associated Brain Tumors: Diagnosis Using Magnetic Resonance Imaging -- 22. Growth of Malignant Gliomas In Vivo: High-Resolution Diffusion Tensor Magnetic Resonance Imaging -- Part V. Therapy -- 23. Resection of Brain Lesions: Use of Preoperative Functional Magnetic Resonance Imaging and Diffusion Tensor Tractography -- 24. Paradigms in Tumor Bed Radiosurgery Following Resection of Brain Metastases -- 25. Rat Model of Malignant Brain Tumors: Implantation of Doxorubicin Using Drug Eluting Beads for Delivery -- 26. Electromagnetic Neuronavigation for CNS Tumors -- 27. Stereotactic Radiosurgery for Intracranial Ependymomas -- 28. Is Whole Brain Radiotherapy Beneficial for Patients with Brain Metastases? -- 29. Triggering Microglia Oncotoxicity: A Bench Utopia or a Therapeutic Approach? -- 30. Preoperative Motor Mapping -- 31. Intraoperative Monitoring for Cranial Base Tumors -- 32. Brain Tumours: Pre-clinical Assessment of Targeted, Site Specific Therapy Exploiting Ultrasound and Cancer Chemotherapeutic Drugs -- Part VI. Quality of Life -- 33. Headaches in Patients with Brain Tumors -- 34. Headache Associated with Intracranial Tumors -- 35. Patients with Brain Cancer: Health Related Quality of Life -- 36. Emerging Role of Brain Metastases in the Prognosis of Breast Cancer Patients.
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Tumors of the Central Nervous System. Volume 5, Astrocytomas, Hemangioblastomas, and Gangliogliomas

https://libcat.nshealth.ca/en/permalink/provcat40879
edited by M.A. Hayat. --Dordrecht: Springer , c2012.
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The most recent developments in diagnostic and therapeutic aspects of Gliomas (glioblastoma) in the brain are presented. áThe importance of personalized medicine and clinical validation for targeted therapy are discussed. The identification of various types of biomarkers (determined by molecular genetics) is included, along with their advantages and limitations as markers in tumor detection and diagnosis. The identification and validation of brain cancer (glioblastoma) genes are discussed. The …
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Hayat, M.A
Responsibility
edited by M.A. Hayat
Alternate Title
Astrocytomas, hemangioblastomas, and gangliogliomas
Place of Publication
Dordrecht
Publisher
Springer
Date of Publication
c2012
Physical Description
1 online resource (xxv, 290 p. : ill.)
Series Vol.
v. 5
Series Title
Tumors of the central nervous system
ISBN
9789400720190
9789400720183 (print ed.)
Subjects (MeSH)
Astrocytoma
Central Nervous System Neoplasms
Ganglioglioma
Hemangioblastoma
Abstract
The most recent developments in diagnostic and therapeutic aspects of Gliomas (glioblastoma) in the brain are presented. áThe importance of personalized medicine and clinical validation for targeted therapy are discussed. The identification of various types of biomarkers (determined by molecular genetics) is included, along with their advantages and limitations as markers in tumor detection and diagnosis. The identification and validation of brain cancer (glioblastoma) genes are discussed. The role of cancer stem cells in the initiation and persistence of malignant gliomas is explained; response of glioblastoma cancer stem cells to various growth factors, such as epidermal growth factor receptor kinase inhibitor, is explained. The use of surgical resection, chemotherapy (e.g., temozolomide), immunotherapy, and radiation therapy for glioblastoma patients is included. Biological impediments for chemotherapy and radiotherapy for malignant glioblastoma are pointed out. Standard (established) as well as newer imaging modalities (proton magnetic resonance spectroscopy) are discussed. Also included are proton magnetic resonance spectroscopy in intracranial gliomas, and the use of proton magnetic spectroscopic imaging in determining the infiltration zone in gliomas. The role of molecular signaling in the CNS cancer development is explained, including cell death signaling in glioblastoma multiforme.
Contents
Part I. Astrocytomas: Diagnosis and Biomarkers -- 1. Methylation in Malignant Astrocytomas -- 2. Deciphering the Function of Doppel Protein in Astrocytomas -- 3. Astrocytic Tumors: Role of Antiapoptotic Proteins -- 4. Deregulation of the Wnt/ß-Catenin/Tcf Signaling Pathway in Astrocytomas -- 5. Subependymal Giant Cell Astrocytoma: Role of mTOR Pathway and Its Inhibitors -- 6. Role of Progesterone Receptor Isoforms in Human Astrocytomas Growth -- 7. Astrocytic Tumors: Role of Carbonic Anhydrase IX -- 8. Development of Cysts in Pilocytic Astrocytomas: Role of Eosinophilic Granular Bodies (Method) -- 9. Role of Synemin in Astrocytoma Cell Migration -- 10. Diffuse Astrocytomas: Immunohistochemistry of MGMT Expression -- 11. Central Nervous System Germ Cell Tumors: An Epidemiology Review -- 12. RAF Fusion Genes and MAPK Activation in Pilocytic Astrocytomas -- 13. Biomarker Discovery in Central Nervous System Neoplasms: Past, Present and Future -- 14. Astrocytomas: Role of Taurine in Apoptosis Using Magnetic Resonance Spectroscopy -- 15. Imaging of Hypoxia-Inducible Factor-1-Active Regions in Tumors Using a POS and 123I-IBB Method -- 16. Diffuse Low-Grade Astrocytomas: P53-Mediated Inhibition of Angiogenesis -- 17. Spontaneous Regression of Cerebellar Astrocytomas -- 18. Subependymal Giant Cell Astrocytoma: Gene Expression Profiling -- Part II. Astrocytomas: Therapy -- 19. Time-Resolved Laser Induced Fluorescence Spectroscopy (TRLIFS): A Tool for Intra-operative Diagnosis of Brain Tumors and Maximizing Extent of Surgical Resection -- 20. Magnetic Resonance-Guided Laser Interstitial Thermal Therapy for Brain Tumors -- 21. Nanotechnology-Based Therapy for Malignant Tumors of the Central Nervous System -- 22. Pilocytic Astrocytoma: Pathological and Immunohistochemical Factors Affecting Surgical Treatment and Surveillance -- 23. Pilomyxoid Astrocytomas: Chemotherapy -- Part III. Astrocytomas: Prognosis -- 24. Astrocytomas: Predicting Survival and Recurrence Using Cerebral Blood Volume Measurements -- 25. Electronic Patient-Reported Outcome Monitoring (ePROM) in Brain Tumour Patients -- Part IV. Hemangioblastoma -- 26. Intra-operative ICG Use in the Management of Hemangioblastomas -- 27. Hemangioblastoma Cysts: Diagnosis Using Fluorescence with 5-Aminolevulinic Acid -- 28. Hemangioblastoma: Stereotactic Radiosurgery -- Part V. Ganglioglioma -- 29. Gangliogliomas: Molecular Pathogenesis and Epileptogenesis -- 30. Epilepsy-Associated Gangliogliomas: Identification of Genes with Altered Expression.
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Tumors of the Central Nervous System. Volume 11, Pineal, Pituitary, and Spinal Tumors

https://libcat.nshealth.ca/en/permalink/provcat39671
M.A. Hayat, editor. --Dordrecht: Springer Netherlands , c2014.
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Like the ten preceding volumes in the series Tumors of the Central Nervous System, this book is distinguished for its comprehensive approach, its distinguished roster of some 93 contributors representing 8 different countries and its embrace of leading-edge technology and methods. Volume 11: Pineal, Pituitary, and Spinal Tumors concentrates on the diagnosis, prognosis and therapy of four types of tumors, namely Glioblastoma, Meningioma, Schwannoma and Spinal Tumors. The book offers an in-depth …
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Other Authors
Hayat, M.A
Responsibility
M.A. Hayat, editor
Place of Publication
Dordrecht
Publisher
Springer Netherlands
Date of Publication
c2014
Physical Description
1 online resource (xlv, 371 p. : 56 illus., 37 illus. in color)
Series Vol.
v. 11
Series Title
Tumors of the central nervous system
ISBN
9789400770379
9789400770362 (print ed.)
ISSN
2215-096X
Subjects (MeSH)
Brain neoplasms
Central Nervous System Neoplasms
Glioblastoma
Meningioma
Neurilemmoma
Radiosurgery
Spinal Cord Neoplasms
Abstract
Like the ten preceding volumes in the series Tumors of the Central Nervous System, this book is distinguished for its comprehensive approach, its distinguished roster of some 93 contributors representing 8 different countries and its embrace of leading-edge technology and methods. Volume 11: Pineal, Pituitary, and Spinal Tumors concentrates on the diagnosis, prognosis and therapy of four types of tumors, namely Glioblastoma, Meningioma, Schwannoma and Spinal Tumors. The book offers an in-depth survey of a range of new technologies and their applications to tumor diagnosis, treatment and therapy assessment. The contributors explain in thorough detail a range of current and newly developed imaging methods, including molecular imaging and PET scan. Also covered is molecular profiling of brain tumors to select therapy in clinical trials of brain tumors. Discussion includes a review of such surgical treatments as resection and the application of non-invasive stereotactic radiosurgery for treating high-risk patients with brain metastasis. Additional discussion is devoted to tumor seeding.
Contents
Part I. Imaging -- An introduction to brain tumor imaging -- Molecular imaging of brain tumors -- Use of 11c-4dst-pet for imaging of human brain tumors -- Part II. Glioma and glioblastoma -- Diffusion tensor magnetic resonance imaging-based tractography for glioma surgery -- Angiocentric glioma, pilomyxoid astrocytoma, and Pituicytoma: new entities in the World Health Organization classification -- Diffuse intrinsic pontine gliomas in children: treatment (an Update) -- Gliomatosis cerebri: implications of genetic findings -- Impact of bevacizumab chemotherapy on glioblastomas -- Glioblastoma microvesicles transport rna and proteins Promoting tumor growth -- Microrna in the pathophysiology of glioblastoma -- Surgical management of incidental low-grade gliomas -- Part III. Stereotactic radiosurgery -- Stereotactic radiosurgery for the treatment of brain metastases -- Local control of low-volume brain metastases using stereotactic radiosurgery -- Tumor seeding after stereotactic brain biopsy -- Intracranial stereotactic radiosurgery in high risk patients with metastases from radioresistant primary tumors -- Brain metastases: treatment with stereotactic iodine-125 brachytherapy -- Stereotactic radiosurgery for skull base meningiomas -- Part IV. Spinal cord tumors -- Pediatric spinal cord tumors -- Radiosurgery for intramedullary spinal cord tumors -- Novalis spinal radiosurgery -- Etiology and outcomes of pediatric spinal cord tumors -- Part V. Meningioma -- Selection of elderly meningioma patients for surgery using a Clinical-radiological grading system as a predictor of outcome -- Cranial meningioma in neurofibromatosis type 2 patients: role of mutations -- Classification of meningioma using immunogenic antigens -- Treatment of benign meningiomas using radiosurgery -- Necrotic rhabdoid meningiomas: histopathological diagnosis -- Part VI. Schwannomas -- Multiple schwannomas: diagnosis and treatment -- Treatment of patients with vestibular schwanommas using gamma knife radiosurgery -- Schwannomas in the craniocervical region: complete surgical removal -- Cranial base surgery of hypoglossal schwannomas.
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Tumors of the central nervous system. Volume 12, Molecular mechanisms, children's cancer, treatments, and radiosurgery

https://libcat.nshealth.ca/en/permalink/provcat33678
edited by M.A. Hayat. --Dordrecht: Springer , c2014.
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As in the case of its eleven predecessors in the series Tumors of the Central Nervous System, this volume is distinguished for its thorough approach, its roster of 92 distinguished contributors representing 11 different countries and its detailed examination of leading-edge technology and methods. Volume 12: Molecular Mechanisms, Children's Cancer, Treatments, and Radiosurgery offers a comprehensive review of the diagnosis, therapy and prognosis of brain and spinal cord tumors. Coverage extends…
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Other Authors
Hayat, M. A
Responsibility
edited by M.A. Hayat
Alternate Title
Molecular mechanisms, children's cancer, treatments, and radiosurgery
Place of Publication
Dordrecht
Publisher
Springer
Date of Publication
c2014
Physical Description
1 online resource (xlviii, 386 pages)
Series Vol.
v. 12
Series Title
Tumors of the central nervous system
ISBN
9789400772175 (electronic bk.)
9789400772168
Subjects (MeSH)
Central Nervous System Neoplasms - pathology
Central Nervous System Neoplasms - therapy
Subjects (LCSH)
Nervous system - Tumors
Nervous system - Tumors - Treatment
Central Nervous System Neoplasms - therapy
Abstract
As in the case of its eleven predecessors in the series Tumors of the Central Nervous System, this volume is distinguished for its thorough approach, its roster of 92 distinguished contributors representing 11 different countries and its detailed examination of leading-edge technology and methods. Volume 12: Molecular Mechanisms, Children's Cancer, Treatments, and Radiosurgery offers a comprehensive review of the diagnosis, therapy and prognosis of brain and spinal cord tumors. Coverage extends to a large number of tumor types, including neuroblastoma, medulloblastoma, meningioma and chordoma. Molecular profiling of brain tumors to select appropriate therapy in clinical trials of brain tumors is discussed in detail, as is the classification/diagnosis of brain tumors based on function analysis. CDK6 as the molecular regulator of neuronal differentiation in the adult brain, and the role of aquaporins in human brain tumor growth are explained. Discussion also includes tumors affecting children, including neuroblastoma and medulloblastoma. A full chapter is devoted to the role of molecular genetic alterations in medulloblastoma, and another examines survival differences between children and adults with medulloblastoma. The use of various types of imaging methods to diagnose brain tumors is explained. In-depth discussion of treatment options includes stereotactic radiosurgery, endoscopic neurosurgery, electrochemotherapy, transsphenoidal surgery, focal ablation, whole brain radiation therapy and recraniotomy.
Contents
Classification/Diagnosis of Brain Tumors Using Discriminant Function Analysis -- Neuronal Differentiation in the Adult Brain: CDK6 as the Molecular Regulator -- Prolactinomas: Role of VEGF, FGF-2 and CD31 -- Human Brain Tumor Growth: Role of Aquaporins -- Molecular and Functional Characterization of Human Adipocytes -- Inhibition of Neuroblastoma Progression by Targeting Lymphangiogenesis: Role of an Endogenous Soluble Splice-Variant of VEGFR-2 -- Hyperinsulinemia Tends to Induce Growth Without Growth Hormone in Children with Brain Tumors After Neurosurgery -- Childhood Brain Tumours: Proton Beam Therapy -- Pathogenesis of Medulloblastoma: Role of Molecular Genetic Alterations -- Medulloblastomas: Survival Differences Between Children and Adults -- Survivors of Childhood Cancer: Risk of Glioma and Meningioma Following Radiotherapy -- Survivors of Childhood Cancer: Risk of New Primary Neoplasms of the CNS -- Brain Tumor Typing and Therapy Using Combined Ex Vivo Magnetic Resonance Spectroscopy and Molecular Genomics -- Atlas-Based Segmentation of Tumor-Bearing Brain Images -- Nonthermal Irreversible Electroporation as a Focal Ablation Treatment for Brain Cancer -- The Role of Whole Brain Radiation Therapy for Metastatic Brain Tumors -- Craniotomy for Intracranial Tumors: Role of Postoperative Hematoma in Surgical Mortality -- Pituitary Adenomas: Treatment Using the Endonasal Approach -- Intracranial Tumors: Treatment with Endoscopic Neurosurgery -- Incidence of Recraniotomy for Postoperative Infections After Surgery for Intracranial Tumors -- Transsphenoidal Surgery for Non-Adenomatous Tumors: Effect on Pituitary Function -- Treatment of Brain Tumors: Electrochemotherapy -- Comparison of Navigated Transcranial Magnetic Stimulation to Direct Electrical Stimulation for Mapping the Motor Cortex Prior to Brain Tumor Resection -- The Role of Glutathione and the Glutathione-Linked Enzyme Systems in Brain Tumor Drug Resistance -- Drugs for Primary Brain Tumors: An Update -- Neurosurgical Treatment for Brain Metastases: Clinical Features, Operative Strategies, Recurrence and Survival -- Image-Guided Radiosurgery for Hypothalamic Hamartomas -- Image-Guided Stereotactic Radiosurgery for Spinal Pathology -- Image-Guided Stereotactic Radiosurgery for Optic Nerve Sheath Meningiomas -- Brain Metastases: The Application of Stereotactic Radiosurgery and Technological Advances -- Treatment of Chordomas by Stereotactic Radiosurgery with a Linear Accelerator: Comparison with Other Modes.
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e-Book
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Tumors of the central nervous system. Volume 13, Types of tumors, diagnosis, ultrasonography, surgery, brain metastasis, and general CNS diseases

https://libcat.nshealth.ca/en/permalink/provcat33714
edited by M.A. Hayat. --Dordrecht: Springer , c2014.
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Volume 13: Pineal, Pituitary, and Spinal Tumors is organized in six sections, for convenience and quick access to critical information. Section I, Types of Tumors includes a chapter on molecular characterization of Embryonal tumors, a chapter on diagnosis of metastatic oligodendroglioma using fine-needle aspiration cytology, one covering intra-arterial chemotherapy of oligodendroglial tumors and another on the role of cyclooxygenase-2 in the development and growth of Schwannomas, and others, cl…
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Other Authors
Hayat, M. A
Responsibility
edited by M.A. Hayat
Alternate Title
Types of tumors, diagnosis, ultrasonography, surgery, brain metastasis, and general CNS diseases
Place of Publication
Dordrecht
Publisher
Springer
Date of Publication
c2014
Physical Description
1 online resource (xliii, 308 pages)
Series Vol.
13
Series Title
Tumors of the central nervous system
ISBN
9789400776029 (electronic bk.)
9789400776012
Subjects (MeSH)
Central Nervous System Neoplasms
Subjects (LCSH)
Nervous system - Tumors
Nervous system - Tumors - Treatment
Abstract
Volume 13: Pineal, Pituitary, and Spinal Tumors is organized in six sections, for convenience and quick access to critical information. Section I, Types of Tumors includes a chapter on molecular characterization of Embryonal tumors, a chapter on diagnosis of metastatic oligodendroglioma using fine-needle aspiration cytology, one covering intra-arterial chemotherapy of oligodendroglial tumors and another on the role of cyclooxygenase-2 in the development and growth of Schwannomas, and others, closing with a chapter on trigeminal neuralgia with cerebellopontine angle tumors. Section II, Diagnosis, includes two chapters on cell counting in histopathologic slides of tumors. Section III offers three chapters which discuss aspects of intraoperative ultrasonography. Section IV covers brain tumor surgery, and Section V surveys Brain Metastasis. The final section offers a wide-ranging review of General Diseases, with chapters on, among others, Alexander Disease; Lipoma; Transplantation of human umbilical cord blood mononuclear cells in cases of neonatal hypoxic-ischemic brain damage; and a chapter discussing the use of mobile phones and brain cancer risk in children. Like its twelve predecessors in the series, this volume merits distinction for its thorough approach, its roster of 78 distinguished contributors representing 14 different countries and its detailed examination of leading-edge technology and methods.
Contents
Part I. Types of tumors -- Embryonal tumor: molecular characterization -- Oligodendroglial tumors: intra-arterial chemotherapy -- Metastatic oligodendroglioma: diagnosis with fine-needle Aspiration cytology -- Management of hemangiopericytoma -- Role of cyclooxygenase-2 in the development and growth of Schwannomas -- Adult primary gliosarcoma: epidemiology -- Mesenchymal chondrosarcoma in the central nervous system: Histological diagnosis -- Supratentorial primitive neuroectodermal tumors (pnets) -- Retinoblastoma and reproductive decisionmaking -- Trigeminal nerualgia with cerebellopontine angle tumors -- Part II. Diagnosis -- The concept of a preniche for cell counting in histopathologic slides of tumors -- Computer systems for cell counting in histopathologic slides of Tumours of the central nervous system: advantages and limitations -- Part III. Ultrasonography -- Intraoperative ultrasonography in tumor surgery. Advantage of intraoperative power doppler ultrasonography for intracranial tumors -- Intraoperative ultrasound in neurosurgical oncology-scope and utility -- Part IV. Surgery -- Resection of brain tumors: intraoperative confocal microscopy technology -- Brainstem cavernomas, accessible lesions: surgery -- The role of surgical resection for metastatic brain tumors -- Part V. Brain metastasis -- Factors responsible for local recurrence of brain metastasis -- Role of mmp2 in brain metastasis -- Differentiating choroid plexus tumors from metastatic -- Carcinomas: use of inwardly rectifying k+ channel kir7.1 and excitatory amino acid transporter-1 -- Part VI. General diseases -- Alexander disease: role of glial fibrillary acidic protein -- Lipoma: an overview -- Tumefactive demyelination -- Immunotherapies for brain cancer: from preclinical models to human trials -- The role of hyaluronic acid and its receptors invasion of brain tumors -- Neonatal hypoxic-ischemic brain damage: human umbilical cord -- Blood mononuclear cells transplantation -- Pathological angiogenesis: an overview -- Use of mobile phones and brain cancer risk in children?
Format
e-Book
Location
Online
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Tumors of the Central Nervous System. Volume 14, Glioma, Meningioma, Neuroblastoma, and Spinal Tumors

https://libcat.nshealth.ca/en/permalink/provcat39538
M.A. Hayat, editor. (1st ed.) --Dordrecht: Springer Netherlands , c2015.
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Location
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This fourteenth volume of the series provides comprehensive, current information on the diagnosis, therapy and prognosis of brain tumors and spinal tumors. For the readers' convenience, contributions are organized into three categories of Pineal Tumors, Pituitary Tumors, and Spinal Tumors. Readers will find discussion of various aspects of a number of tumor types, including angiocentric glioma, pilomyxoid astrocytoma, pituicytoma, pediatric low-grade gliomas, meningiomas and spinal cord tumors.…
Available Online
View e-Book
Other Authors
Hayat, M.A
Responsibility
M.A. Hayat, editor
Edition
1st ed.
Alternate Title
Glioma, Meningioma, Neuroblastoma, and Spinal Tumors
Place of Publication
Dordrecht
Publisher
Springer Netherlands
Date of Publication
c2015
Physical Description
1 online resource (xxxviii, 98 p. : 14 illus., 9 illus. in color)
Series Vol.
v. 14
Series Title
Tumors of the central nervous system
ISBN
9789401772242
9789401772235 (print ed.)
ISSN
2215-096X
Subjects (MeSH)
Central Nervous System Neoplasms
Glioma
Meningeal Neoplasms
Meningioma
Neuroblastoma
Spinal Neoplasms
Abstract
This fourteenth volume of the series provides comprehensive, current information on the diagnosis, therapy and prognosis of brain tumors and spinal tumors. For the readers' convenience, contributions are organized into three categories of Pineal Tumors, Pituitary Tumors, and Spinal Tumors. Readers will find discussion of various aspects of a number of tumor types, including angiocentric glioma, pilomyxoid astrocytoma, pituicytoma, pediatric low-grade gliomas, meningiomas and spinal cord tumors. Expert oncologists, neurosurgeons, physicians, research scientists and pathologists from around the world have contributed to this extensive publication. Their chapters highlight practical experience and provide exceptional insight into the nature of cancer. The authors cover topics ranging from the use of molecular criteria in diagnosis and targeting of medicine, through evidence-based approaches, to in-depth discussion of long-term follow-up after surgery. This handbook, as earlier volumes in the series, will appeal to professionals involved in the treatment of cancer, as well as to researchers. The series crosses subjects of diagnosis, drug development, therapy and its assessment and prognosis of tumors of the central nervous system, cancer recurrence and resistance to chemotherapy.
Contents
1. Angiocentric Glioma, Pilomyxoid Astrocytoma, and Pituicytoma: New Entities in the World Health Organization Classification -- 2. Pediatric Low-Grade Gliomas: Diagnosis, Treatment, and Future Directions -- 3. Kringle 1-5 Reduces Growth of Malignant Gliomas in Rats -- 4. Fluorescence Guided Resection and Photodynamic Therapy in Meningiomas -- 5. Classification of Meningiomas in the Cerebellopontine Angle -- 6. Postoperative Cerebral Hyperemia: Pathophysiology and Clinical Concerns -- 7. Evidence-Based Approach for the Management of Cerebral Metastases From Lung Adenocarcinoma -- 8. Intramedullary Spinal Cord Tumors: Long-Term Follow-up After Surgery.
Format
e-Book
Location
Online
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