This practical and instructional guidebook, written by international experts in anterior cruciate ligament (ACL) reconstruction, covers all challenging aspects of ACL rupture in the acute and chronic setting. It covers the latest, spectacular anatomical findings, treatment of partial ACL tears, various techniques for single- and double-bundle ACL reconstruction, and complex ACL revision surgery. Important surgical steps are clearly described with the help of instructive, high-quality photograph…
This atlas documents current surgical approaches to the craniocervical junction and the cervical spine, providing step-by-step guidance on procedures and cervical spine stabilization techniques. Opening chapters present essential information on anatomy, depict pathologies with the aid of illustrative cases, describe the role of imaging techniques in patient evaluation, and discuss surgical instrumentation and patient positioning. The different techniques employed in this delicate anatomic regio…
This new atlas, the fourth of a successful series, is a completely revised and updated edition of a previously published FDG PET-CT atlas. In the past few years, considerable progress has been made in the field of PET-CT imaging, and this new edition takes full account of these recent developments. Furthermore, its educational mission has been broadened: beyond serving as a straightforward guide to FDG PET-CT imaging it now encompasses the integrative use of contrast-enhanced CT and MRI. The ne…
This atlas is a concise but comprehensive guide to the diverse patterns of response to immunotherapy as observed on Positron Emission Tomography/Computed Tomography (PET/CT) and other conventional imaging modalities, including CT and Magnetic Resonance Imaging (MRI). The purpose for this publication is to fill the gap between the growing clinical relevance and utilization of immunotherapy in medical oncology, mainly based on checkpoint inhibitors, and the need for experienced imagers with relia…
This book presents the state of the art in atrophic rhinitis and analyses its specific characteristics in non-allergic rhinitis. Little has been written on this condition, which represents a topical issue in modern clinical practice, and as such many clinicians tend to underestimate its impact on patients’ quality of life. This book covers the definition, aetiology, clinical presentation, diagnosis and management, providing specialists with a better understanding of this condition and of the tr…
Autophagy principally serves an adaptive function to protect organisms against diverse human pathologies, including cancer and neurodegeneration. Recent developments using in vitro, ex vivo and in vivo models show the involvement of the autophagy pathway in immunity and inflammation. Moreover, direct interactions between autophagy proteins and immune signalling molecules have also been demonstrated. Defects in autophagy - similar to cancer, neurodegenerative diseases and aging - through autopha…
This ambitious and comprehensive manual represents an essential contribution to our current understanding of interactions between heart and brain, a research topic generating growing interest. Despite the increasing awareness that neural mechanisms are the primary cause of cardiac disease and its progression, therapy continues to focus on end-organ protection and does not approach the neural core of the problem. Growing public health problems such as heart failure are still treated with autonom…
This book presents state of the art knowledge and practice in the rapidly developing field of bronchiectasis not due to cystic fibrosis (referred to below simply as bronchiectasis). The focus is especially on diagnosis and existing and emerging therapies, but the book also covers a wide range of other key topics, from pathophysiology, histopathology, and immunology through to pulmonary rehabilitation, nursing care, and management in primary care and pediatric settings. While bronchiectasis was …
This book highlights the importance of investigating for ADHD in adults with attention difficulties, poor memory and executive function impairments. The authors advocate a neurodevelopmental assessment approach in all phases of life, and explain how to perform such assessments. The identification of ADHD in adults with other psychiatric and neurological disorders will lead to a better response to treatments, and as a result reduce its social, economic and personal burden. ADHD can no longer be …
Calipered kinematic alignment was proposed by Dr. Stephen M. Howell to enable the accurate and individualized placement of total knee components coincident within ± 0.5 mm of the patient’s pre-arthritic alignment. The aim was to restore the patient's native joint kinematics and thereby address the well documented 20% dissatisfaction when total knee replacement is performed using traditional, or mechanical alignment techniques.
This book provides the reader with the best available evidence on the most pressing issues relating to reconstruction of the anterior cruciate ligament (ACL) with the goal of supporting surgical reconstruction of the ACL and improving outcomes for patients. Key topics for which evidence-based information is presented include selection of graft material and source, the use of different surgical techniques, graft rupture in relation to surgical technique, and progression to osteoarthritis. The bo…
This book provides a practical and comprehensive guide to delivering analgesia and sedation to critically ill patients for professionals and caregivers being involved in the management of these patients. It discusses and explains in detail the advantages and limitations of each drug and device using clear flowcharts, diagrams and tables. Furthermore, it explores the new drugs and—above all—new sedation delivery systems, particularly those for administering volatile anesthetics on ICUs. Written …
This book adopts a novel approach: procedures. Instead of discussing the diagnostic categories of neurological syndromes, it focuses on the symptoms of common neurological presentations (especially in the emergency room or on the ward), and the diagnostic hypotheses that can be validated or rejected case by case as a result. Each chapter covers one of the main symptoms of emergencies in neurology – from transient consciousness disturbances to focal deficits, acute muscular disorders, respirator…