Insulin Therapy : A Pocket Guide
https://libcat.nshealth.ca/en/permalink/provcat32555
Mark W.J. Strachan, Brian M. Frier.
--London:
Springer
, c2013.
- Available Online
- View e-Book
- Location
- Online
Diabetes is extremely common, with approximately 171 million people affected worldwide. The majority of people with diabetes are cared for in primary care. Primary health care professionals are usually adept at dealing with the lifestyle measures and tablet treatments for diabetes, but generally have limited expertise in the initiation and management of insulin therapy. Insulin therapy has also become more complex, with numerous different forms of insulin and more complex delivery devices avail…
- Available Online
- View e-Book
- Author
- Strachan, Mark W.J
- Other Authors
- Frier, Brian M
- Responsibility
- Mark W.J. Strachan, Brian M. Frier
- Place of Publication
- London
- Publisher
- Springer
- Date of Publication
- c2013
- Physical Description
- 1 online resource (vii, 82 p. : 11 ill., 9 ill. in color)
- ISBN
- 9781447147602
- Subjects (MeSH)
- Diabetes Mellitus - drug therapy
- Insulin - therapeutic use
- Subjects (LCSH)
- Diabetes
- Endocrinology
- Abstract
- Diabetes is extremely common, with approximately 171 million people affected worldwide. The majority of people with diabetes are cared for in primary care. Primary health care professionals are usually adept at dealing with the lifestyle measures and tablet treatments for diabetes, but generally have limited expertise in the initiation and management of insulin therapy. Insulin therapy has also become more complex, with numerous different forms of insulin and more complex delivery devices available. In a secondary care setting, approximately 10% of in-patients will have diabetes at any one time. People with diabetes stay in hospital longer than people without diabetes, and the condition is often poorly managed during in-patient stays, often leading to clinical errors. Insulin Therapy: A Pocket Guide provides clear and concise information about the safe prescribing of insulin both subcutaneously and intravenously. It covers the different types of insulin, the delivery devices, side effects of insulin and, most importantly, guidance on rational dose adjustment.This book is an invaluable guide for general practitioners and primary care nurses with a special interest in diabetes, as well as junior hospital doctors and specialist medical trainees, advanced nurse practitioners and new diabetes nurse specialists.
- Contents
- 1. History, Normal Physiology and Production of Insulin -- 2. Insulins and Regimens in Current Use -- 3. Subcutaneous Insulin Administration -- 4. Initiating and Adjusting Insulin -- 5. Side-Effects of Insulin -- 6. Intravenous Insulin -- 7. Use of Insulin in Hospitals.
- Format
- e-Book
- Location
- Online
In Vivo Cryotechnique in Biomedical Research and Application for Bioimaging of Living Animal Organs
https://libcat.nshealth.ca/en/permalink/provcat40408
Shinichi Ohno, Nobuhiko Ohno, Nobuo Terada, editors.
(1st ed.)
--Tokyo:
Springer Japan
, c2016.
- Available Online
- View e-Book
- Location
- Online
This book focuses on actual morphofunctional findings of cells and tissues in living animal organs. Medical and biological scientists need to know the real in vivo morphology and immunolocalization of the molecular components in living animal organs. Recently, the live imaging of cells and tissues of animals with fluorescence-labeled proteins by gene manipulation has become more and more popular in biological fields. Current research, meanwhile, has revealed that immunohistochemical or morpholo…
- Available Online
- View e-Book
- Other Authors
- Ohno, Shinichi
- Ohno, Nobuhiko
- Terada, Nobuo
- Responsibility
- Shinichi Ohno, Nobuhiko Ohno, Nobuo Terada, editors
- Edition
- 1st ed.
- Place of Publication
- Tokyo
- Publisher
- Springer Japan
- Date of Publication
- c2016
- Physical Description
- 1 online resource (xi, 300 p. : 114 illus., 99 illus. in color)
- ISBN
- 9784431557234
- 9784431557227 (print ed.)
- Subjects (MeSH)
- Animal Structures - anatomy & histology
- Biopsy - methods
- Cryoelectron Microscopy - methods
- Freeze Substitution - methods
- Intravital Microscopy - methods
- Mice - anatomy & histology
- Abstract
- This book focuses on actual morphofunctional findings of cells and tissues in living animal organs. Medical and biological scientists need to know the real in vivo morphology and immunolocalization of the molecular components in living animal organs. Recently, the live imaging of cells and tissues of animals with fluorescence-labeled proteins by gene manipulation has become more and more popular in biological fields. Current research, meanwhile, has revealed that immunohistochemical or morphological studies exclusively depend on living animal organs. The cryotechnique is one of the most useful tools for immunohistochemistry and bioimaging of animal organs. This book describes the epoch-making cryotechnique originally developed by the editors. The book also makes the management of living animal morphology more accessible not only for biomedical researchers but also for clinical doctors, providing a valuable resource work on the current perspectives of in vivo morphology.
- Contents
- Part I. Overview -- 1. Introduction -- 2. Biomedical significance and development of "IVCT" -- 3. How to perform "IVCT" -- 4. Technical merits with "IVCT" -- Part II. Application of "IVCT" to various mouse organs -- 5. Histochemical Analyses of Living Mouse Liver under Different Hemodynamic Conditions -- 6. Three-dimensional reconstruction of liver tissues with confocal laser scanning microscopy -- 7. Application of "in vivo cryotechnique" to immunohistochemical detection of hypoxia in mouse liver tissues treated with pimonidazole -- 8. Immunohistochemical detection of soluble immunoglobulins in small intestines -- 9. Detection of MAPK signal transduction proteins in an ischemia/reperfusion model of small intestines -- 10. Histological Study and LYVE-1 Immunolocalization of Mesenteric Lymph Nodes -- 11. Distribution of immunoglobulin-producing cells in immunized mouse spleens -- Chapter12. Alteration of erythrocyte shapes in various organs of living mice or under blood flow conditions -- 13. Dynamic ultrastructure of smooth muscle cells in dystrophin-deficient mdx or normal scn mice -- 14. Dynamic Bioimaging of Serum Proteins in Beating Mouse Hearts -- 15. Histochemical analyses and quantum dot imaging of microvascular blood flow with pulmonary edema -- 16. Dynamic ultrastructure of pulmonary alveoli of living mice under respiratory conditions -- 17. Immunohistochemical analysis of various serum proteins in living mouse thymus -- 18. Immuno- and enzyme-histochemistry of HRP for demonstration of blood vessel permeability in mouse thymic tissues -- 19. Immunolocalization of serum proteins in living mouse glomeruli under various hemodynamic conditions -- 20. Immunohistochemical Analyses on Albumin and IgG in Acute Hypertensive Mouse Kidneys -- 21. Application of novel "in vivo cryotechnique" in living animal kidneys -- 22. Application of periodic acid-Schiff fluorescence emission for imunohistochemistry of living mouse renal glomeruli -- 23. Immunohistochemical analyses on serum proteins in nephrons of protein-overload mice -- 24. Immunohistochemical analyses of serum proteins in puromycin aminonucleoside nephropathy of living rat kidneys -- 25. Immunolocalization of phospho-Arg-directed protein kinase-substrate in hypoxic kidneys -- 26. Dynamic ultrastructures of renal glomeruli in living mice under various hemodynamic conditions -- 27. Function of dynamin-2 in formation of discoid vesicles in urinary bladder umbrella cells -- 28. Involvement of follicular basement membrane and vascular endothelium in blood-follicle barrier formation of mice -- 29. Permselectivity of blood-follicle barriers in mouse polycystic ovary model -- 30. Application of "in vivo cryotechnique" to immunohistochemical study of serum albumin in normal and cadmium-treated mouse testis organs -- 31. Immunohistochemical detection of angiotensin II receptors in mouse cerebellum -- 32. Application of "in vivo cryotechnique" to immunohistochemical analyses for effects of anoxia on serum immunoglobulin and albumin leakage through blood-brain barrier in mouse cerebellum -- 33. Extracellular Space in Central Nervous System -- 34. Overview on recent applications of in vivo cryotechnique in neurosciences -- 35. Application of "in vivo cryotechnique" to immunohistochemical detection of phosphorylated rhodopsin in light-exposed retina of living mouse -- 36. Application of "in vivo cryotechnique" to immunohistochemical detection of glutamate in mouse retina inner segment of photoreceptors -- 37. Application of ǣin vivo cryotechniqueǥ to immunohistochemical study of mouse sciatic nerves under various stretching conditions -- Part III. Further preparation after "IVCT" -- 38. Freeze-substitution (FS) fixation method -- Part IV. Comments on advantages of "IVCT" -- 39. Cryotechniques and freeze-substitution for immunostaining of intranuclear antigens and fluorescence in situ hybridization -- 40. Replica immunoelectron microscopy for caveolin in living smooth muscle cells -- 41. Application of "in vivo cryotechnique" to detection of injected fluorescence-conjugated IgG in living mouse organs -- 42. Application of "in vivo cryotechnique" to visualization of microvascular blood flow in mouse kidney by quantum dot injection -- Part V. Direct detection of molecules by Raman microscopy -- 43. Application of "in vivo cryotechnique" to Raman microscopy of freeze-dried mouse eyeball-slice -- 44. Application of "in vivo cryotechnique" to detection of erythrocyte oxygen saturation in mouse blood vessels with confocal Raman cryomicroscopy -- Part VI. Future development for human pathology -- 45. Imaging of thrombosis and microcirculation in mouse lungs of initial melanoma metastasis -- 46. Differential distribution of blood-derived proteins in xenografted human adenocarcinoma tissues -- Part VII. New cryobiopsy invention -- 47. Morphological and Histochemical Analysis of Living Mouse Livers by New "Cryobiopsy" Technique -- 48. Recent Development of In Vivo Cryotechnique to Cryobiopsy for Living Animals -- Part VIII. Application of cryobiopsy for living animal tissues -- 49. Significance of cryobiopsy for morphological and immunohistochemical analyses of xenografted human lung cancer tissues and functional blood vessels -- 50. Immunolocalization of serum proteins in xenografted mouse model of human tumor cells -- 51. Histochemical approach of cryobiopsy for glycogen distribution in living mouse livers under fasting and local circulation loss conditions -- Part IX. New bioimaging of living animal tissues -- 52. Bioimaging of fluorescence-labeled mitochondria in subcutaneously grafted murine melanoma cells by the 'in vivo cryotechnique" -- 53. Application of "in vivo cryotechnique" to visualization of ATP with luciferin-luciferase reaction in mouse skeletal muscles -- 54. Concluding remarks.
- Format
- e-Book
- Location
- Online
