Osteosarcoma
https://libcat.nshealth.ca/en/permalink/provcat40400
Takafumi Ueda, Akira Kawai, editors.
(1st ed.)
--Tokyo:
Springer Japan
, c2016.
- Available Online
- View e-Book
- Location
- Online
This book reviews the brilliant progress made in the past three decades in clinical outcomes for osteosarcoma patients treated with a multidisciplinary approach, including limb-salvage surgery combined with neoadjuvant multidrug chemotherapy and aggressive management of pulmonary metastasis. Osteosarcoma was a miserable disease for adolescents and young adults until the early 1970s, with a survival rate that was less than 10-15% even after amputation for affected limbs because of the progressio…
- Available Online
- View e-Book
- Other Authors
- Ueda, Takafumi
- Kawai, Akira
- Responsibility
- Takafumi Ueda, Akira Kawai, editors
- Edition
- 1st ed.
- Place of Publication
- Tokyo
- Publisher
- Springer Japan
- Date of Publication
- c2016
- Physical Description
- 1 online resource (xi, 270 p. : 105 illus., 27 illus. in color)
- ISBN
- 9784431556961
- 9784431556954 (print ed.)
- Subjects (MeSH)
- Bone Neoplasms
- Combined Modality Therapy
- Limb Salvage
- Osteosarcoma
- Abstract
- This book reviews the brilliant progress made in the past three decades in clinical outcomes for osteosarcoma patients treated with a multidisciplinary approach, including limb-salvage surgery combined with neoadjuvant multidrug chemotherapy and aggressive management of pulmonary metastasis. Osteosarcoma was a miserable disease for adolescents and young adults until the early 1970s, with a survival rate that was less than 10-15% even after amputation for affected limbs because of the progression of pulmonary metastasis. With the development of neoadjuvant chemotherapy for osteosarcoma, including high-dose methotrexate, doxorubicin, cisplatin, and ifosfamide during the late 1970s and the 1980s, however, the prognosis has dramatically improved. Limb-salvage surgery for patients with extremity osteosarcoma is now a gold-standard surgical procedure for more than 90% of patients with localized disease. Additionally, aggressive pulmonary metastasectomy for patients with lung metastasis from osteosarcoma has contributed to improvement of their survival. More recently, carbon-ion radiotherapy has also been introduced for patients with unresectable osteosarcoma of the trunk, as in the spine and pelvis. In this volume the author provides valuable descriptions of an important new treatment modality for a multidisciplinary approach for osteosarcoma patients.
- Contents
- Part I. Basic Research and Experimental Therapy -- 1. Genetics of Osteosarcoma -- 2. Basic Research for Osteosarcoma Lung Metastasis (LM8) -- 3. Immunotherapy for Osteosarcoma -- Part II. Clinical Features -- 4. Outcome of Treatment for Osteosarcoma of the Extremities Over the Last 20 Years: Report from 11 Referral Centers in Japan -- 5. Osteosarcoma in the Elderly: Clinical Features and Outcome -- 6. Prognostic Factors for Osteosarcoma Patients -- Part III. Chemotherapy -- 7. Neoadjuvant Chemotherapy Developed in Japan -- 8. Neoadjuvant Chemotherapy: Osaka University Osteosarcoma (OOS) Regimen -- Part IV. Surgery -- 9. Endoprosthetic Reconstruction for Extremity Osteosarcoma -- 10. Limb-Salvage Surgery and Reconstruction for Skeletally Immature Childhood Osteosarcoma: Extendible Endoprosthesis -- 11. Limb Salvage Surgery for Pelvic Osteosarcoma -- 12. Management of Postoperative Infection After Limb Salvage Surgery in Osteosarcoma Patients -- Part V. Surgery: Biological Reconstruction -- 13. Biological Reconstruction for Extremity Osteosarcoma: Long-Term Results and Current Concept of Intraoperative Extracorporeal Irradiated Bone Graft (IORBG) -- 14. Biological Reconstruction for Extremity Osteosarcoma: Pasteurized Autogenous Bone Graft -- 15. Biological Reconstruction for Extremity Osteosarcoma: Liquid Nitrogen-Treated Tumor-Bearing Bone Graft -- 16. Biological Reconstruction for Extremity Osteosarcoma: Distraction Osteogenesis Technique -- 17. Limb-Saving Surgery Using In Situ Preparation (ISP) Method -- Part VI. Unresectable/Metastatic Disease -- 18. Carbon Ion Radiotherapy for Unresectable Osteosarcoma of the Trunk -- 19. Treatment of Osteosarcoma Patients with Pulmonary Metastasis -- Part VII. Quality of Life -- 20. Long-Term Outcomes and Quality of Life (QOL) in Survivors of Pediatric and Adolescent Osteosarcoma.
- Format
- e-Book
- Location
- Online
