The field of adipose tissue biology has been expanding at a very rapid pace in the last few years. Numerous advances have been made since publication of the first edition of this book, in terms of basic adipocyte biology, understanding of the determinants of obesity, distribution of body fat and weight loss, as well as the mechanisms linking excess adiposity to various co-morbidities. Adipose Tissue and Adipokines in Health and Disease, Second Edition contains updated chapters from the previous…
This book describes the different aspects of aortic valve and root diseases including comprehensive discussion of the state-of-the-art diagnostic imaging options, disease risk stratification, selection of candidates for valve repair or percutaneous intervention, and most recent therapeutic options. The growing prevalence of valvular heart disease represents a major challenge in terms of short- and long-term management and surveillance. Aortic valve diseases, including aortic stenosis and regurg…
This book describes adverse cutaneous drug reactions as among the most frequent events in patients receiving drug therapy. Cardiovascular drugs are an important group as there are a greater number of indications for the use of new drugs and their prescription continues to increase. The exact incidence of cutaneous side effects from cardiovascular drugs is difficult to estimate due to sporadic reporting. Moreover, a reliable connection between a certain drug and a certain type of reaction can on…
This book provides an updated overview of agammaglobulinemia, a rare form of primary immunodeficiency which is considered the prototype of the congenital humoral defects, and which is characterized by the absence of peripheral B cells and very low serum immunoglobulin levels. The book opens by discussing the highly orchestrated early B cell development in the bone marrow and the genes involved based on both human and animal models. The pathogenesis and clinical presentation of X-linked agammagl…
This ambitious book provides a comprehensive history of the World Health Organization (WHO) Global Programme on AIDS (GPA), using it as a unique lens to trace the global response to the AIDS pandemic. The authors describe how WHO came initially to assume leadership of the global response, relate the strategies and approaches WHO employed over the years, and expound on the factors that led to the Programme's demise and subsequent formation of the Joint United Nations Programme on HIV/AIDS (UNAID…
Alternative medicine (AM) is hugely popular; about 40% of the US general population have used at least one type of alternative treatment in the past year, and in Germany this figure is around 70%. The money spent on AM is considerable: the global market is expected to reach nearly US {dollar} 200 billion by 2025, with most of these funds coming directly out of consumers’ pockets. The reasons for this popularity are complex, but misinformation is certainly a prominent factor. The media seem to h…
This book tells the intriguing and often colorful stories of the medical words we use. The origins of clinical and scientific terms can be found in Greek and Latin myths, in places such as jungles of Uganda and the islands of the Aegean Sea, in the names of medicine's giants such as Hippocrates and Osler, and in some truly unlikely sources. In this book you will learn the answers to questions such as: What disease was named for an American space flight? Do you know the echoic word for elephanti…
This concise, accessible book covers anesthesia for hepatico-pancreatic-biliary (HPB) surgery and transplantation, based on randomized clinical trials, meta-analyses, case series, reports, and hands-on experience. The anatomy, physiology, pathophysiology and clinical consequences are discussed, and the close ties between HPB resection and transplant anesthesia are explored. The content reflects current real-world practice, as liver and pancreatic transplant surgeries have substantially improved…
Popliteal aneurysms are still controversial in terms of their pathogenesis, and challenging in terms of their treatment. This book offers a detailed overview of the latest advances in our understanding of the disease, and highlights the latest theories. Divided into eght sections, it focuses on: the historical background, embryology and anatomy of the popliteal artery, clinical presentation and diagnosis, pros and cons of traditional surgical techniques, pros and cons of advanced endovascuar te…
This book presents the latest evidence and guidelines supporting the use of anticoagulant therapy for various clinical scenarios. The field of anticoagulation therapy is evolving rapidly, particularly since the arrival and widespread adoption of direct oral anticoagulants. Organized in two parts, this book reviews the pharmacologic properties of various anticoagulants and details the clinical applications of anticoagulant therapy. Drugs such as warfarin and unfractionated heparin, as well as pa…
This book provides a case-based overview of aortic stenosis including pathophysiology, presentation, diagnosis with both invasive, and multimodality noninvasive techniques, and how to approach management options in the multidisciplinary setting. It provides both an assessment of challenging cases that appear to be complex in terms of determining the true severity of aortic stenosis as well as a review of current available treatment options, such as valvuloplasty, transcatheter, and surgical val…
This textbook introduces students to the basic concepts and methods used to measure and compare the expected benefits, risks and cost of preventive and therapeutic medical interventions. It provides an easily accessible overview of comparative effectiveness and its practical applications to daily medical decisions. The book includes learning objectives for each topic, definitions of key terms and topic summaries. Each chapter is written by a highly regarded academic and extensive reference is m…
This book provides a thorough overview of the ongoing evolution in the application of artificial intelligence (AI) within healthcare and radiology, enabling readers to gain a deeper insight into the technological background of AI and the impacts of new and emerging technologies on medical imaging. After an introduction on game changers in radiology, such as deep learning technology, the technological evolution of AI in computing science and medical image computing is described, with explanation…
Spanning both the history and future of knee replacement, this unique book recounts how artificial knees have reached the stage they are today, and whether their performance can be further improved. The author, who has been designing artificial knees for 50 years, starts the story in the late 1960’s with the early pioneers; during the 1970’s, the principles for successful artificial knees were established. While many different types were designed, a small number have become by far the most wide…
The integration of clinical findings, laboratory results, and disease progression is critical for the diagnosis and treatment of patients with skin lymphoma. This atlas includes numerous clinical and histological images with diagrams, tables, and text describing each type of lymphoma in the current cutaneous classification scheme, which includes information on the recent classification scheme for cutaneous lymphoma published by the World Health Organization and the European Organization for Res…
Diabetes mellitus is increasing in incidence, prevalence, and importance as a chronic disease throughout the world. The International Diabetes Federation projects that by 2030 there will be 438 million people with diabetes on a global scale. In the United States, the Centers for Disease Control calculates that 25.8 million people (or 8.3% of the population) have diabetes and nearly 2 million Americans develop diabetes each year. Thus, the burden of diabetes is enormous in terms of the magnitude…
This book describes in practical terms the endoscopic neurosurgery of the third ventricle and surrounding structures, emphasizing aspects of intraoperative endoscopic anatomy and ventricular approaches for main diseases, complemented by CT/MRI images. It is divided in two parts: Part I describes the evolution of the description of the ventricular system and traditional ventricular anatomy, besides the endoscopic neurosurgery evolution and current concepts, with images and schematic drawings, wh…
Dermatopathology often presents considerable difficulty for the dermatologist in training when defining the subtle differences in the appearance of various conditions. This Atlas of Essential Dermatopathology is based on materials developed during dermatopathology teaching signout at the Massachusetts General Hospital and replicates the experience at the microscope. It contains numerous hand drawn sketches and tables plus stunning histological images to describe the appearances of common dermat…