This book provides the first comprehensive overview of a new scientific discipline termed Geroscience. Geroscience examines the molecular and cellular mechanisms that might explain why aging is the main risk factor for most chronic diseases affecting the elderly population. Over the past few decades, researchers have made impressive progress in understanding the genetics, biology and physiology of aging. This book presents vital research that can help readers to better understand how aging is a…
This book synthesizes the major research advances in molecular, biochemical, and translational aspects of aging and heart failure over the last four decades and addresses future directions in management and drug discovery. It presents clinical issues and molecular mechanisms related to heart failure, including the changing demographics in the aging population with heart failure; hypertension and prevention of diastolic heart failure in the aging population; polypharmacy and adverse drug reactio…
This book describes the fundamental process of senescence, and reviews a new concept developed by a number of research groups that is based on cellular senescence and its secretome. This concept provides a basic explanation of the main physiological and pathological features of senescence, and delineates possibilities for “treating” it. Following an introduction to the emerging medical landscape, the increasing incidence of a new epidemiological group (age-related “chronic non-transmissible dis…
This state-of-the-art review on longevity focuses on centenarians, studied as a model of positive biology. The extraordinary rise in the elderly population in developed countries underscores the importance of studies on ageing and longevity in order to decrease the medical, economic and social problems associated with the increased number of non-autonomous individuals affected by invalidating pathologies. Centenarians have reached the extreme limits of human life span. Those in relatively good …
This resource features 60 chapters written by the world's elite clinicians from neurology, geriatrics and research on all aspects of geriatric neurology, and the authors have incorporated the geriatric care perspective and a quality-oriented approach to health care throughout, resulting in the definitive reference for all clinicians caring for older people as well as for those who set policies that affect research and clinical practice.
This book addresses why and how the aging process is accelerated under diabetes, providing valuable and comprehensive information for the management of various types of diabetes- and aging-related disorders. Since several papers have shown that average life span and healthy life expectancy are reduced in diabetic patients, especially in those with a long history of disease, the early detection and treatment of diabetes-related complications are urgently needed in order to slow the aging process…
This text provides a comprehensive review of the latest research on the effects of dietary patterns and whole plant foods on general health, aging, and cardiometabolic disease risk from major prospective cohort studies and randomized controlled trials (RCTs) and their meta-analyses. The book extensively assesses the effects of lifestyle, dietary patterns, and specific whole plant foods on the quality of aging; the impact of fiber-rich foods on colonic microbiotia and weight regulation, the effe…
Surgical and anesthetic techniques have evolved to allow a growing number of older adults to undergo surgery, and current estimates are that 50% of Americans over the age of 65 years old will have an operation. However, as the knowledge regarding perioperative care of the elderly surgical patient grows, so do the questions. In this edition, each chapter includes a section entitled "Gaps in Our Knowledge," meant to highlight areas in which research is needed, as well as hopefully inspire readers…