Molecular Allergy Diagnostics : Innovation for a Better Patient Management
https://libcat.nshealth.ca/en/permalink/provcat41424
Jörg Kleine-Tebbe, Thilo Jakob, editors.
--Cham:
Springer
, 2017.
- Available Online
- View e-Book
- Location
- Online
This book, based on a recent German publication, offers an overview of basic data and recent developments in the groundbreaking field of molecular allergology. It comprehensively explores the origin and structure of single allergen molecules ("components") and their utility in improving the management of type I, IgE-mediated allergic reactions and disorders like allergic respiratory diseases, food allergies, and anaphylaxis. Highly specific testing, called component-resolved diagnostics, aims t…
- Available Online
- View e-Book
- Other Authors
- Kleine-Tebbe, Jörg
- Jakob, Thilo
- Responsibility
- Jörg Kleine-Tebbe, Thilo Jakob, editors
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- 2017
- Physical Description
- 1 online resource (xx, 531 pages) : 112 illus., 100 illus. in color
- ISBN
- 9783319424996
- 9783319424989 (print ed.)
- Subjects (MeSH)
- Allergens - immunology
- Biomarkers - analysis
- Hypersensitivity - diagnosis
- Immunoglobulin E - immunology
- Molecular Diagnostic Techniques
- Sensitivity and Specificity
- Abstract
- This book, based on a recent German publication, offers an overview of basic data and recent developments in the groundbreaking field of molecular allergology. It comprehensively explores the origin and structure of single allergen molecules ("components") and their utility in improving the management of type I, IgE-mediated allergic reactions and disorders like allergic respiratory diseases, food allergies, and anaphylaxis. Highly specific testing, called component-resolved diagnostics, aims to identify and utilize single molecules. Over 200 single allergens from plant or animal sources have been applied to single or multiplex laboratory testing for the presence of allergen-specific IgE. This leap in assay sensitivity and specificity has led to three major advances in patient management: discrimination between primary allergic sensitization and complex cross-reactivity, recognition of IgE profiles for certain allergens and identification of patients most likely to benefit from allergen-specific immunotherapy. The book discusses in detail the benefits and limitations of this 21st century technology, and offers suggestions for the use of molecular allergology in routine clinical practice. It is a "must read" for physicians treating allergic patients as well as scientists interested in natural allergic molecules and their interactions with the human immune system.
- Contents
- Part I: Protein Families and Relationships -- 1. Introduction to Molecular Allergology: Protein Families, Databases, and Potential Benefits -- 2. Bet v 1 and its Homologs: Triggers of Tree-Pollen Allergy and Birch Pollen-Associated Cross-Reactions -- 3. The Concept of Pollen Panallergens: Profilins and Polcalcins -- 4. Stable Plant Food Allergens I: Lipid-Transfer Proteins -- 5. Stable Plant Food Allergens II: Storage Proteins -- 6. Cross-Reactive Carbohydrate Determinants: Diagnostic and Clinical Relevance -- Part II: Test Systems, Singleplex Analysis and Multiplex Analysis -- 7. Molecular Allergy Diagnostics Using IgE Singleplex Assays: Methodological and Practical Considerations -- 8. Spiking with Recombinant Individual Allergens for Improvement of Allergen Extracts -- 9. Molecular Allergy Diagnostics Using Multiplex Assays -- Part III: Marker Allergens -- 10. Marker Allergens and Panallergens in Tree and Grass Pollen Allergy -- 11. Marker Allergens of Weed Pollen: Basic Considerations and Diagnostic Benefits in Routine Clinical Practice -- 12. Molecular Diagnostics for Peanut Allergy -- 13. Molecular Diagnostics for Tree Nut Allergy -- 14. Molecular Diagnostics of Allergy to Fruits and Vegetables -- 15. Cow’s Milk and Hen’s Egg Allergy: What Do Molecular-Based Allergy Diagnostics Have to Offer? -- 16. Molecular and Extract-Based Diagnostics in Meat Allergy -- 17. Molecular Diagnostics in Food-Dependent Exercise-Induced Anaphylaxis -- 18. Benefits and Limitations of Recombinant Allergens in Diagnostics of Insect Venom Allergy -- 19. Molecular Diagnostics in Allergy to Mammals -- 20. Extract-Based and Molecular Diagnostics in Fish Allergy -- 21. Allergens and Molecular Diagnostics of Shellfish Allergy -- 22. Allergens, Diagnostics, and Therapeutic Aspects in House Dust Mite Allergy -- 23. Cockroach, Tick, Storage Mite, and Other Arthropod Allergies: Molecular Aspects -- 24. Mold Allergens and Their Importance in Molecular Allergy Diagnosis -- 25. Latex Allergens: Source of Sensitization and Single Allergens -- Part IV: Designer Allergens, Hypoallergens and Fusion Allergens -- 26. Recombinant Allergens in Specific Immunotherapy -- 27. Definition and Design of Hypoallergenic Foods.
- Format
- e-Book
- Location
- Online
