Chronic Hepatitis C Virus : Advances in Treatment, Promise for the Future
https://libcat.nshealth.ca/en/permalink/provcat30939
Mitchell L. Shiffman, editor.
--New York, NY:
Springer
, c2012.
- Available Online
- View e-Book
- Location
- Online
Chronic Hepatitis C Virus: Advances in Treatment, Promise for the Future documents the monumental advances that have been made in our understanding of chronic HCV during the past decade. The first section reviews the natural history of chronic HCV, how this virus can affect other organs in addition to the liver, and whether treating chronic HCV alters the natural history of this disease. Section 2 reviews the advances that have been made in the treatment of chronic HCV during the past decade wi…
- Available Online
- View e-Book
- Other Authors
- Shiffman, Mitchell L
- Responsibility
- Mitchell L. Shiffman, editor
- Place of Publication
- New York, NY
- Publisher
- Springer
- Date of Publication
- c2012
- Physical Description
- 1 online resource (xvi, 332 p. : 53 ill., 33 ill. in color)
- ISBN
- 9781461411925
- Subjects (MeSH)
- Antiviral Agents - therapeutic use
- Hepacivirus - pathogenicity
- Hepatitis C, Chronic - therapy
- Liver Transplantation
- Specialty
- Gastroenterology
- Virology
- Abstract
- Chronic Hepatitis C Virus: Advances in Treatment, Promise for the Future documents the monumental advances that have been made in our understanding of chronic HCV during the past decade. The first section reviews the natural history of chronic HCV, how this virus can affect other organs in addition to the liver, and whether treating chronic HCV alters the natural history of this disease. Section 2 reviews the advances that have been made in the treatment of chronic HCV during the past decade with interferon based therapy. Separate chapters on response guided therapy and how to manage the adverse events associated with these medications provide the physician with the concepts required to more effectively treat chronic HCV now and in the future. As the genetics of virologic response have recently been elucidated, a chapter is devoted to helping the clinician understand how genes that modulate disease processes and their treatment are identified and utilized in clinical care. Section 3 deals with the future of HCV treatment and specific inhibitors of HCV. Specific chapters explain how targets for drugs are identified and how drugs are then developed and tested; how mutations of HCV develop and how anti-viral agents will affect this process; the most up to date data regarding the treatment of chronic HCV with peginterferon, ribavirin and anti-viral agents; and the potential to treat chronic HCV with just oral anti-viral agents and without peginterferon and ribavirin in the future. The final section of this book covers issues related to liver transplantation in patients with chronic HCV. Separate chapters review the natural history of chronic HCV in liver transplant recipients and the impact of utilizing HCV positive donors. The volume concludes with chapters that cover the treatment of chronic HCV both prior to and after liver transplantation with potent anti-viral agents. Chronic Hepatitis C Virus: Advances in Treatment, Promise for the Future is a valuable resource for all physicians caring for patients with chronic HCV.
- Contents
- Epidemiology of Chronic HCV -- Acute HCV -- Assessing the Progression of Chronic HCV to Cirrhosis -- Chronic HCV and Steatosis -- Chronic HCV and Hepatocellular Carcinoma -- Extrahepatic Manifestations of Chronic HCV -- Chronic HCV and HIV Co-infection -- Chronic HCV in Patients with Renal Disease -- Does Treatment Alter the Natural History of Chronic HCV -- Treatment with Interferon and Ribavirin -- Immune Modulators and Other Agents -- Measuring HCV RNA and Assessing Virologic Response -- Response Guided Therapy -- Managing the Side Effects of Therapy -- The Genetics of Virologic Response -- Maintenance Therapy with Peginterferon -- Anti-viral Targets in HCV -- Mutations and the Development of Anti-viral Resistance -- Peginterferon, Ribavirin and Anti-viral Triple Therapy -- Treating Chronic HCV without Interferon and/or Ribavirin -- Maintenance Therapy with Oral Anti-viral Agents -- Natural History of Chronic HCV after Liver Transplantation -- Use of HCV Positive Organs in Patients with and without Chronic HCV -- Treating HCV Prior to Liver Transplantation -- Treating HCV after Liver Transplantation.
- Format
- e-Book
- Location
- Online
Hepatitis C Virus II : Infection and Disease
https://libcat.nshealth.ca/en/permalink/provcat40421
Tatsuo Miyamura, Stanley M. Lemon, Christopher M. Walker, Takaji Wakita, editors.
--Tokyo:
Springer Japan
, c2016.
- Available Online
- View e-Book
- Location
- Online
This book helps scientists, clinicians and other interested individuals understand recent clinical advances and challenges for the future. It covers many basic aspects of the pathogenesis of chronic hepatitis C, HCV infections in particular populations, approaches to therapy, and prevention and control of HCV Infection. The book provides a succinct review of the large amount of data generated by multiple groups over the past two decades that has revealed the natural history of HCV infection. Si…
- Available Online
- View e-Book
- Other Authors
- Miyamura, Tatsuo
- Lemon, Stanley M
- Walker, Christopher M
- Wakita, Takaji
- Responsibility
- Tatsuo Miyamura, Stanley M. Lemon, Christopher M. Walker, Takaji Wakita, editors
- Place of Publication
- Tokyo
- Publisher
- Springer Japan
- Date of Publication
- c2016
- Physical Description
- 1 online resource (ix, 372 p. : 25 illus., 23 illus. in color)
- ISBN
- 9784431561019
- 9784431560999 (print ed.)
- Subjects (MeSH)
- Antiviral Agents - therapeutic use
- Hepatitis C, Chronic
- Hepatitis C Virus
- Specialty
- Gastroenterology
- Virology
- Abstract
- This book helps scientists, clinicians and other interested individuals understand recent clinical advances and challenges for the future. It covers many basic aspects of the pathogenesis of chronic hepatitis C, HCV infections in particular populations, approaches to therapy, and prevention and control of HCV Infection. The book provides a succinct review of the large amount of data generated by multiple groups over the past two decades that has revealed the natural history of HCV infection. Similarly, it summarizes current understanding of the origins of HCV-associated hepatocellular carcinoma, cirrhosis and hepatic fibrosis. Extra-hepatic manifestation and metabolic disorders related to HCV infection are described. In this volume, these clinically important aspects of HCV infection are comprehensively described. Highlights are description of newly developed direct- acting antivirals. The authors represent a worldwide distribution of leaders in the field reflecting the global nature of HCV infection. Based on recent data concerning the genetic- and geographical diversity of HCV, and increased global disease burden of HCV infection, challenges for global control of HCV infections are described.
- Contents
- Part I. Chronic Hepatitis C -- Natural History of Chronic Hepatitis C -- The Multifaceted Features of HCV Infection Beyond the Liver -- Hepatic Fibrosis in Hepatitis C -- Hepatocellular Carcinoma and Hepatitis C Virus -- HCV, Alcohol, and the Liver -- Extrahepatic Replication of HCV -- Part II. HCV Infections in Special Populations -- Hepatitis C Virus Infection in Pregnancy and Childhood -- Part III. Approaches to Therapy -- Host Genetics and Responses to Antiviral Therapy in Chronic Hepatitis C -- Viral Variation and Response to Therapy -- HCV NS3/4A Protease Inhibitors and the Road to Effective Direct-Acting Antiviral Therapies -- Mechanism of Action of Direct-Acting Antivirals: New Insights into the HCV Life Cycle -- Modeling HCV Dynamics in Clinical Practice to Personalize Antiviral Therapy -- Part IV. Prevention and Control of HCV Infection -- Prophylactic Vaccines for the Hepatitis C Virus -- Global Control of Hepatitis C Virus Infection.
- Format
- e-Book
- Location
- Online
Hepatitis C Virus Treatment : Highly Effective Therapy with Direct Acting Antivirals and Associated Viral Resistance
https://libcat.nshealth.ca/en/permalink/provcat41957
Kazuaki Chayama, editor.
--Singapore:
Springer
, 2017.
- Available Online
- View e-Book
- Location
- Online
This book introduces readers to Direct Acting Antiviral (DAAs) agents, newly developed drugs to treat chronic hepatitis C virus infection, which have an excellent anti-viral effect on virus replication. These drugs have been developed to enhance the effect of interferon and ribavirin, as the resistant strains against each drug have been described both in vitro and in vivo and the existences of naturally occurring variants have been reported. However, since the combination of different classes o…
- Available Online
- View e-Book
- Other Authors
- Chayama, Kazuaki
- Responsibility
- Kazuaki Chayama, editor
- Place of Publication
- Singapore
- Publisher
- Springer
- Date of Publication
- 2017
- Physical Description
- 1 online resource (vii, 75 pages) : 23 illus., 14 illus. in color
- ISBN
- 9789811024160
- 9789811024153 (print ed.)
- Subjects (MeSH)
- Antiviral Agents - therapeutic use
- Drug Resistance, Viral
- Hepacivirus - drug effects
- Hepatitis C - drug therapy
- Treatment Outcome
- Specialty
- Gastroenterology
- Virology
- Abstract
- This book introduces readers to Direct Acting Antiviral (DAAs) agents, newly developed drugs to treat chronic hepatitis C virus infection, which have an excellent anti-viral effect on virus replication. These drugs have been developed to enhance the effect of interferon and ribavirin, as the resistant strains against each drug have been described both in vitro and in vivo and the existences of naturally occurring variants have been reported. However, since the combination of different classes of DAAs is sufficient to completely eradicate the virus without the need for interferon or ribavirin, the current treatment regimen does not include interferon. Ribavirin is used in combination with sofosbuvir, a potent polymerase inhibitor, to enhance its antiviral effects. Hepatitis C Virus Treatment offers readers a comprehensive guide to hepatitis C; describing the resistance profiles against these drugs and shedding light on the difficulties involved in DAA therapy and the direction of future treatments, it will equip doctors to understand the essentials of treating the disease. It also describes in detail new and innovative DAA treatments, the effects of the agents, and the characteristics of resistance, providing cutting-edge information not only for hepatologists, but also for researchers, clinical residents, and medical students.
- Contents
- 1. Treatment of Chronic Hepatitis C with the First-Generation Protease Inhibitor Telaprevir: Its Efficacy and Resistance Mutations -- 2. Features of the Second Wave of the First Generation Protease Inhibitors: Effect and Tolerance -- 3. The Efficacy of Daclatasvir Plus Asunaprevir Combination Therapy with Chronic Hepatitis -- 4. Resistance-Associated Variants in the NS5A Region of HCV and Methods for the Detection -- 5. Detection of Antiviral Drug-Resistant Variants in Chronic Hepatitis C by Deep Sequencing -- 6. Incidence and Characteristics of Naturally Occurring Drug-Resistant Hepatitis C Virus Strains -- 7. Treatment Effects and Resistance- Associated Variants of Sofosbuvir Regimen for Japanese Patients with Chronic Hepatitis C Virus Genotypes 1 and 2 -- 8. Emerging Antivirals in the Future.
- Format
- e-Book
- Location
- Online
