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Antibodies for Treating Cancer

https://libcat.nshealth.ca/en/permalink/provcat46839
Melvyn Little. Springer , 2021.
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Online
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Responsibility
Melvyn Little
Publisher
Springer
Date of Publication
2021
Physical Description
1 online resource (xi, 151 pages) : illustrations
ISBN
9783030725990
Specialty
Biological Therapy
Medical Oncology
Format
e-Book
Location
Online
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Asthma : Targeted Biological Therapies

https://libcat.nshealth.ca/en/permalink/provcat41552
Girolamo Pelaia, Alessandro Vatrella, Rosario Maselli. --Cham: Springer , 2017.
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This book focuses on the fundamentals of the use of biologics in asthma, describing the rationale, principles, mechanisms of action, and indications. It offers an excellent balance between basic science and the analysis of clinical trials, updating readers with new developments that are changing the global scenario for targeted biological anti-asthma therapies, especially with regard to more severe disease. A range of therapies are considered, from the humanized monoclonal anti-IgE antibody oma…
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Author
Pelaia, Girolamo
Other Authors
Vatrella, Alessandro
Maselli, Rosario
Responsibility
Girolamo Pelaia, Alessandro Vatrella, Rosario Maselli
Place of Publication
Cham
Publisher
Springer
Date of Publication
2017
Physical Description
1 online resource (vi, 99 pages) : 11 illus. in color
ISBN
9783319460079
9783319460055 (print ed.)
Subjects (MeSH)
Asthma - drug therapy
Biological Therapy
Precision Medicine
Abstract
This book focuses on the fundamentals of the use of biologics in asthma, describing the rationale, principles, mechanisms of action, and indications. It offers an excellent balance between basic science and the analysis of clinical trials, updating readers with new developments that are changing the global scenario for targeted biological anti-asthma therapies, especially with regard to more severe disease. A range of therapies are considered, from the humanized monoclonal anti-IgE antibody omalizumab, widely approved as add-on treatment for inadequately controlled disease, through to emerging biologics for which evidence supportive of efficacy is accumulating, including anti-IL-5, anti-IL-4, and anti-IL-13 therapies. One aspect to emerge is the variability in individual response, which suggests a need for characterization of different asthma subtypes to permit the effective implementation of phenotype-targeted treatments. This book will be of interest for pulmonologists, clinical immunologists, and physicians seeking sound information on these therapies, but also for scientists and pharmacologists wishing to enhance their knowledge of the therapeutic implications of the cellular and molecular mechanisms that underlie severe, uncontrolled asthma.
Contents
1. Introduction -- 2. Inflammatory Cellular Patterns in Asthma -- 3. Airway Remodelling in Asthma -- 4. Anti-IgE Therapy -- 5. IL-5-Targeted Antibodies -- 6. Anti-IL-4/IL-13 Biologics -- 7. Anti-TNF-a Therapies -- 8. Biologic Treatments Targeted to Innate Cytokines -- 9. Other Biologic Drugs -- 10. Conclusions and Future Perspectives.
Format
e-Book
Location
Online
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Atlas of Response to Immunotherapy

https://libcat.nshealth.ca/en/permalink/provcat45029
Egesta Lopci, Stefano Fanti, editors. --Cham: Springer , c2020.
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This atlas is a concise but comprehensive guide to the diverse patterns of response to immunotherapy as observed on Positron Emission Tomography/Computed Tomography (PET/CT) and other conventional imaging modalities, including CT and Magnetic Resonance Imaging (MRI). The purpose for this publication is to fill the gap between the growing clinical relevance and utilization of immunotherapy in medical oncology, mainly based on checkpoint inhibitors, and the need for experienced imagers with relia…
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Other Authors
Lopci, Egesta
Fanti, Stefano
Responsibility
Egesta Lopci, Stefano Fanti, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2020
Physical Description
1 online resource (viii, 127 p.) : 111 illus., 100 illus. in color
ISBN
9783030311131
9783030311124 (Print ed.)
9783030311148 (Print ed.)
9783030311155 (Print ed.)
Subjects (MeSH)
Immunotherapy - methods
Neoplasms - immunology
Neoplasms - therapy
Positron Emission Tomography Computed Tomography
Treatment Outcome
Specialty
Biological Therapy
Medical Oncology
Abstract
This atlas is a concise but comprehensive guide to the diverse patterns of response to immunotherapy as observed on Positron Emission Tomography/Computed Tomography (PET/CT) and other conventional imaging modalities, including CT and Magnetic Resonance Imaging (MRI). The purpose for this publication is to fill the gap between the growing clinical relevance and utilization of immunotherapy in medical oncology, mainly based on checkpoint inhibitors, and the need for experienced imagers with reliable tools assessing response to treatment. A series of disease-oriented chapters will present the imaging findings during immunotherapy in the major oncological settings, with helpful comparison of functional (PET/CT) and morphological (CT/MRI) patterns of response in individual cases. To complete the atlas, a dedicated chapter will focus on major pitfalls and immune-related adverse events (irAEs) affecting image interpretation during the course of immunotherapy. The concluding chapter will lastly examine the available data and potential developments of immuno-PET, which is considered as the novel frontier of research in this oncological scenario. The atlas will be of high value for radiologists and nuclear medicine specialists at all levels of experience.
Contents
Part I. Brief Introduction -- 1. Immunotherapy in Oncology -- 2. Evolution of Response Criteria in Immunotherapy -- Part II. Disease-Oriented Applications -- 3. CNS Tumors: PET/CT and MRI for Response Assessment of CNS Tumors Following Immunotherapy -- 4. Lung Cancer: 18F-FDG PET/CT for Response Assessment of Lung Following Immunotherapy -- 5. Malignant Pleural Mesothelioma: 18F-FDG PET/CT for Response Assessment of Malignant Pleural Mesothelioma Following Immunotherapy -- 6. Melanoma: 18F-FDG PET/CT for Response Assessment of Melanoma Following Immunotherapy -- 7. Genitourinary Tumors: PET/CT for Response Assessment of Genitourinary Tumors Following Immunotherapy -- 8. Hematologic Malignancies: PET/CT for Response Assessment of Hematologic Malignancies Following Immunotherapy -- 9. Other Tumor Types: 18F-FDG PET/CT for Response Assessment of Various Tumors Following Immunotherapy -- Part III. Potential Pitfalls to Response Assessment -- 10. Pitfalls and Immune-Related Adverse Events -- Part IV. New Radiopharmaceuticals -- 11. ImmunoPET: The Future of Response Evaluation for Cancer Immunotherapy.
Format
e-Book
Publication Type
Atlas
Location
Online
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Best Practices of Apheresis in Hematopoietic Cell Transplantation

https://libcat.nshealth.ca/en/permalink/provcat45065
Syed A. Abutalib, Anand Padmanabhan, Huy P. Pham, Nina Worel, editors. --Cham: Springer , c2020.
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In this book, world-renowned experts in the field of hematopoietic cell transplantation examine a range of issues and controversies relating to apheresis, with the aim of identifying current trends and best practices. Readers will find up-to-date guidance on donor evaluation, CD34+ cell mobilization strategies, options and selection of apheresis device, anticoagulation techniques in apheresis, the role of prediction algorithms in determining procedure eligibility and length, and the prevention …
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Other Authors
Abutalib, Syed A.
Padmanabhan, Anand
Pham, Huy P.
Worel, Nina
Responsibility
Syed A. Abutalib, Anand Padmanabhan, Huy P. Pham, Nina Worel, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2020
Physical Description
1 online resource (vi, 211 p.) : 33 illus., 29 illus. in color
Series Title
Advances and controversies in hematopoietic transplantation and cell therapy
ISBN
9783319551319
9783319551302 (Print ed.)
9783319551326 (Print ed.)
ISSN
2569-1376
Subjects (MeSH)
Blood Component Removal - methods
Hematopoietic Stem Cell Transplantation - methods
Specialty
Biological Therapy
Hematology
Abstract
In this book, world-renowned experts in the field of hematopoietic cell transplantation examine a range of issues and controversies relating to apheresis, with the aim of identifying current trends and best practices. Readers will find up-to-date guidance on donor evaluation, CD34+ cell mobilization strategies, options and selection of apheresis device, anticoagulation techniques in apheresis, the role of prediction algorithms in determining procedure eligibility and length, and the prevention and management of complications. Applications of apheresis devices in the processing of bone marrow grafts are discussed, and detailed attention is devoted to the indications and rationale for therapeutic apheresis procedures, with individual chapters focusing on therapeutic plasma exchange and immunoadsorption, red cell exchange, and extracorporeal photopheresis. Finally, the applications of apheresis in pediatric donors and in resource-limiting environments are considered. This book, featuring numerous helpful tables, algorithms, and figures, will be of high practical value for residents, fellows, faculty members and other healthcare personnel involved in hematopoietic cell transplantation.
Contents
1. Introduction and Rationale -- 2. Administrative and Regulatory Considerations for Apheresis Collection Facilities -- 3. FACT-JACIE Standards: Common Citations and How Best to Avoid Them -- 4. Donor Evaluation for Hematopoietic Stem and Progenitor Cell Collection -- 5. Mobilization Strategies: HPC(A) Collections for Autologous Hematopoietic Cell Transplants -- 6. Mobilization Strategies: HPC(A) Collections for Allogeneic Hematopoietic Cell Transplants -- 7. Hematopoietic Progenitor Cells, Apheresis and Therapeutic Cells, T-Cells Collection: Instrumentation, Operating Parameters, and Troubleshooting -- 8. Anticoagulation and Other Periprocedural Considerations for Apheresis -- 9. Concepts and Rationale for Using Predictive Algorithms for Hematopoietic Progenitor Cell Apheresis Collection -- 10. Applications of Apheresis Devices in Processing Bone Marrow Grafts -- 11. Therapeutic Plasma Exchange and Immunoadsorption: Indications and Implementation -- 12. Red Blood Cell Exchange: When and Why? -- 13. Extracorporeal Photopheresis in Hematopoietic Cell Transplantation -- 14. Prevention and Management of Apheresis Complications -- 15. Challenges and Optimization of Apheresis Procedures in Resource-Limiting Environments.
Format
e-Book
Location
Online
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Biological therapies in psychiatry newsletter

https://libcat.nshealth.ca/en/permalink/provcat15374
Gelenberg
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Holdings
Halifax Infirmary: v. 12, 1989 - v. 38, 2015.
Location
Halifax Infirmary
Publisher
Gelenberg
Holdings
Halifax Infirmary: v. 12, 1989 - v. 38, 2015.
Publication Frequency
Monthly
ISSN
1044-422X
Specialty
Biological Therapy
Pharmacology
Psychiatry
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Format
Journal
Location
Halifax Infirmary
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Biomedicine and pharmacotherapy

https://libcat.nshealth.ca/en/permalink/provcat19452
Elsevier
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Vol 61, 2007 -
Location
Online
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Publisher
Elsevier
Holdings
Vol 61, 2007 -
Publication Frequency
8 p/year
ISSN
0753-3322
Specialty
Biological Therapy
Pharmacology
Format
e-Journal
Location
Online
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Biotherapy : History, Principles and Practice : A Practical Guide to the Diagnosis and Treatment of Disease using Living Organisms

https://libcat.nshealth.ca/en/permalink/provcat40852
Martin Grassberger, Ronald A. Sherman, Olga S. Gileva, Christopher M.H. Kim, Kosta Y. Mumcuoglu, editors. --Dordrecht: Springer , c2013.
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Biotherapy as defined by the International Biotherapy Society is the use of living organisms in the treatment and diagnosis of human diseases. Although modern day Western medicine has often little understanding for living creatures in daily medical practice, there is a long-standing tradition in many of the biotherapy modalities. This volume is an evocative exploration of the history, scientific basis and practical use of living organisms in medicine. The authors provide researchers and practit…
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Other Authors
Grassberger, Martin
Sherman, Ronald A
Gileva, Olga S
Kim, Christopher M.H
Mumcuoglu, Kosta Y
Responsibility
Martin Grassberger, Ronald A. Sherman, Olga S. Gileva, Christopher M.H. Kim, Kosta Y. Mumcuoglu, editors
Place of Publication
Dordrecht
Publisher
Springer
Date of Publication
c2013
Physical Description
1 online resource (xvi, 309 p. : 91 illus., 72 illus. in color)
ISBN
9789400765856
9789400765849 (print ed.)
Subjects (MeSH)
Animal Assisted Therapy
Apitherapy
Biological Therapy - methods
Early Detection of Cancer
Hirudin Therapy
Therapy with Helminths
Abstract
Biotherapy as defined by the International Biotherapy Society is the use of living organisms in the treatment and diagnosis of human diseases. Although modern day Western medicine has often little understanding for living creatures in daily medical practice, there is a long-standing tradition in many of the biotherapy modalities. This volume is an evocative exploration of the history, scientific basis and practical use of living organisms in medicine. The authors provide researchers and practitioners interested in this field, with cutting-edge material on the latest key advances in the following fields of biotherapy: Maggot Therapy: The use of blowfly larvae for chronic wound treatment Hirudotherapy: The application of medicinal leeches for extraction of blood from congested or inflamed tissues, in a wide range of pathologies Bee Venom Therapy: The use of honey bee venom for the treatment of inflammatory diseases Apitherapy: The use of bee products for numerous chronic ailments. Ichthyotherapy: The use of small fresh-water fish for dermatological conditions such as psoriasis Helminth Therapy: The use of nematode worms as agents for stimulation of host immunological responses appropriate for the alleviation of certain inflammatory diseases Phage Therapy: The therapeutic use of bacteriophages to treat bacterial infections Animal Assisted Therapy: The application of dogs and horses for people with physical, psychological, cognitive, social, and behavioral problems Canine Olfactory Detection: The training of dogs to recognize medical conditions such as cancer and diabetic crises In addition, the authors provide with their chapters an extensive bibliography that represents a state-of-the-art survey of the literature. Comprehensive and current, this fresh volume of reviews is an essential resource for professionals who need to stay ahead of the game in the exciting field of biotherapy.
Contents
Biotherapy: an Introduction -- Maggot Therapy -- Hirudotherapy -- Apitherapy: Bee Venom Therapy -- Apitherapy: The Use of Honeybee Products -- Ichthyotherapy -- Helminth Therapy -- Phage Therapy -- Animal Assisted Therapy: Benefits and Challenges -- Equine Assisted Therapy: An Overview -- Canine Olfactory Detection of Human Disease.
Format
e-Book
Location
Online
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Chimeric antigen receptor T-cell therapies for cancer : a practical guide

https://libcat.nshealth.ca/en/permalink/provcat44691
edited by Daniel W. Lee and Nirali N. Shah. --Amsterdam, Netherlands: Elsevier , c2020.
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From patient referral to post-therapy management, Chimeric Antigen Receptor (CAR) T-Cell Therapies for Cancer: A Practical Guide presents a comprehensive view of CAR modified T-cells in a concise and practical format. Providing authoritative guidance on the implementation and management of CAR T-cell therapy from Drs. Daniel W. Lee and Nirali N. Shah, this clinical resource keeps you up to date on the latest developments in this rapidly evolving area.
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Other Authors
Lee, Daniel W.
Responsibility
edited by Daniel W. Lee and Nirali N. Shah
Place of Publication
Amsterdam, Netherlands
Publisher
Elsevier
Date of Publication
c2020
Physical Description
1 online resource, 244 p.
ISBN
9780323661812
Subjects (MeSH)
Cell- and Tissue-Based Therapy
Neoplasms - therapy
Receptors, Antigen, T-Cell
Cytology
Specialty
Biological Therapy
Medical Oncology
Regenerative Medicine
Abstract
From patient referral to post-therapy management, Chimeric Antigen Receptor (CAR) T-Cell Therapies for Cancer: A Practical Guide presents a comprehensive view of CAR modified T-cells in a concise and practical format. Providing authoritative guidance on the implementation and management of CAR T-cell therapy from Drs. Daniel W. Lee and Nirali N. Shah, this clinical resource keeps you up to date on the latest developments in this rapidly evolving area.
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Registration required for PDF access.
Format
e-Book
Location
Online
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Safety of Biologics Therapy : Monoclonal Antibodies, Cytokines, Fusion Proteins, Hormones, Enzymes, Coagulation Proteins, Vaccines, Botulinum Toxins

https://libcat.nshealth.ca/en/permalink/provcat40166
Brian A. Baldo. --Cham: Springer , c2016.
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This long overdue title provides a comprehensive, up-to-date, state-of-the art review of approved biologic therapies, with coverage of mechanisms of action, Indications for therapy, immunogenicity and a detailed examination of adverse effects and safety of the many and diverse therapeutic agents presented in a total of 13 chapters. It is predicted that by 2016, biologics will make up half of the world's 20 top-selling drugs and by 2018, biologic medicine sales will account for almost half of th…
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Author
Baldo, Brian A
Responsibility
Brian A. Baldo
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2016
Physical Description
1 online resource (xxi, 610 p. : 106 illus., 89 illus. in color)
ISBN
9783319304724
9783319304700 (print ed.)
Subjects (MeSH)
Biological Products - therapeutic use
Biological Therapy - methods
Drug-Related Side Effects and Adverse Reactions - prevention & control
Abstract
This long overdue title provides a comprehensive, up-to-date, state-of-the art review of approved biologic therapies, with coverage of mechanisms of action, Indications for therapy, immunogenicity and a detailed examination of adverse effects and safety of the many and diverse therapeutic agents presented in a total of 13 chapters. It is predicted that by 2016, biologics will make up half of the world's 20 top-selling drugs and by 2018, biologic medicine sales will account for almost half of the world's 100 biggest selling drugs. Recombinant proteins dominate the growing list of the more than 200 approved biotherapeutic agents with targeted antibodies, fusion proteins and receptors; cytokines; hormones; enzymes; proteins involved in blood-clotting, homeostasis and thrombosis; vaccines; botulinum neurotoxins; and, more recently, biosimilar preparations, comprising the majority of approved biologics. Written with clinicians, other health care professionals, and researchers in mind, Safety of Biologics Therapy examines, in a single volume, the full range of issues surrounding the safety of approved biologic therapies. A good understanding of the risks and safety issues of modern biologics therapy is increasingly being demanded of all those connected with their development, handling, prescribing, administration and subsequent patient management. In addition to being of great value to clinicians in all branches of medicine, and to nurses, pharmacists and researchers, this book will prove invaluable for students taking undergraduate and graduate courses in the above disciplines and in the biomedical sciences.
Contents
1. Approved Biologics Used For Therapy and their Adverse Effects -- 2. Monoclonal Antibodies: Introduction -- 3. Monoclonal Antibodies Approved for Cancer Therapy -- 4. Other Approved Therapeutic Monoclonal Antibodies -- 5. Cytokines -- 6. Fusion Proteins -- 7. Peptide Hormones -- 8. Glycoprotein Hormones -- 9. Enzymes Approved for Therapy -- 10. Blood Coagulation -- 11. Vaccines -- 12. Botulinum Neurotoxins -- 13. Biosimilars.
Format
e-Book
Location
Online
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Treatment of Inflammatory Bowel Disease with Biologics

https://libcat.nshealth.ca/en/permalink/provcat42935
edited by Adam S. Cheifetz, Joseph D. Feuerstein. --Cham, Switzerland: Springer , c2018.
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This book is a concise yet comprehensive overview of the use of biologics for the treatment of Crohn's disease and ulcerative colitis. The volume details how best to utilize these medications in order to optimize their efficacy and safety, as well as how to understand, recognize, and treat complications that may arise from using biologics to treat IBD. The text also focuses on new data, novel biologics, and biosimilars of this rapidly expanding field. Written by experts in the field, Treatment …
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Other Authors
Cheifetz, Adam S.
Feuerstein, Joseph D.
Responsibility
edited by Adam S. Cheifetz, Joseph D. Feuerstein
Place of Publication
Cham, Switzerland
Publisher
Springer
Date of Publication
c2018
Physical Description
1 online resource (xi, 335 p.) : 22 illus., 19 illus. in color
ISBN
9783319602769
9783319602752 (print ed.)
9783319602776 (print ed.)
9783319868233 (print ed.)
Subjects (MeSH)
Anti-Inflammatory Agents - therapeutic use
Biological Products - therapeutic use
Inflammatory Bowel Diseases - drug therapy
Specialty
Biological Therapy
Gastroenterology
Abstract
This book is a concise yet comprehensive overview of the use of biologics for the treatment of Crohn's disease and ulcerative colitis. The volume details how best to utilize these medications in order to optimize their efficacy and safety, as well as how to understand, recognize, and treat complications that may arise from using biologics to treat IBD. The text also focuses on new data, novel biologics, and biosimilars of this rapidly expanding field. Written by experts in the field, Treatment of Inflammatory Bowel Disease with Biologics is a valuable resource for gastroenterologists, allied health professionals, fellows, and trainees who treat patients with inflammatory bowel disease.
Contents
Mechanism of Action and Pharmacokinetics of Biologics -- Anti-tumor Necrosis Factor Agents in Ulcerative Colitis -- Anti-tumor Necrosis Factor Agents in Crohn's Disease -- Anti-TNF Therapy for Treatment of Extraintestinal Manifestations of Inflammatory Bowel Disease -- Use of Biologics in the Postoperative Management of Crohn's Disease -- Biologics in Pregnancy and Breastfeeding -- Concomitant Use of Immunosuppressive Therapy with Tumor Necrosis Factor (TNF) Antagonists in Inflammatory Bowel Disease -- Therapeutic Drug Monitoring of Biologic Agents -- Use of Biologics in Crohn's Disease and Ulcerative Colitis Prior to Surgery and Perioperative Risks -- Cessation of Biologics—Can it be Done? -- Biologic Therapy in Pediatric Inflammatory Bowel Disease -- Infectious Complications of Biologics -- Tumor Necrosis Factor-Alpha Inhibitors and Risks of Malignancy -- Non-infectious and Non-malignant Complications of Biologics -- Biosimilars in Inflammatory Bowel Disease 2017: State of the Science, State of the Art, State of the Finances -- Anti-Integrin Agents in IBD: Efficacy and Risk of Complications -- Novel Agents in Inflammatory Bowel Disease -- Quality, Safety, and Practical Considerations of Using Biologic Therapies.
Format
e-Book
Location
Online
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