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Advances in Salivary Diagnostics

https://libcat.nshealth.ca/en/permalink/provcat39442
Charles F. Streckfus, editor. --Berlin, Heidelberg: Springer , c2015.
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This book reviews the progress made in salivary diagnostics and identifies the likely direction of future endeavors. After an introductory section describing the histological and anatomical features of the salivary glands and salivary function, salivary collection devices and diagnostic platforms are reviewed. The field of "salivaomics" is then considered in detail, covering, for example, proteomics, the peptidome, DNA and RNA analysis, biomarkers, and methods for biomarker discovery. Salivary …
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Other Authors
Streckfus, Charles F
Responsibility
Charles F. Streckfus, editor
Place of Publication
Berlin, Heidelberg
Publisher
Springer
Date of Publication
c2015
Physical Description
1 online resource (xiii, 204 p. : 48 illus., 38 illus. in color)
ISBN
9783662453995
9783662453988 (print ed.)
Subjects (MeSH)
Biomarkers
Clinical Chemistry Tests
Pathologic Processes - diagnosis
Saliva - physiology
Salivary Glands
Abstract
This book reviews the progress made in salivary diagnostics and identifies the likely direction of future endeavors. After an introductory section describing the histological and anatomical features of the salivary glands and salivary function, salivary collection devices and diagnostic platforms are reviewed. The field of "salivaomics" is then considered in detail, covering, for example, proteomics, the peptidome, DNA and RNA analysis, biomarkers, and methods for biomarker discovery. Salivary diagnostics for oral and systemic diseases are thoroughly discussed, and the role of salivary gland tissue engineering for future diagnostics is explored. The book closes by considering legal issues and barriers to salivary diagnostic development. Advances in Salivary Diagnostics will be an informative and stimulating reference for both practitioners and students.
Contents
1 Introduction -- 2 The History of Salivary Diagnostics -- 3 Saliva Collection Devices and Diagnostic Platforms -- 4 Salivary Omics -- 5 Salivary Diagnostics and the Oral Microbiome -- 6 Development of Nanoparticle- Enabled Protein Biomarker Discovery: Implementation for Saliva-Based Traumatic Brain Injury Detection -- 7 Saliva Diagnostics for Oral Diseases -- 8 Salivary Gland Tissue Engineering and Future Diagnostics -- 9 Using Saliva Secretions to Model Disease Progression.
Format
e-Book
Location
Online
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Atlas of Thyroid and Neuroendocrine Tumor Markers

https://libcat.nshealth.ca/en/permalink/provcat43325
Luca Giovanella, editor. --Cham: Springer , c2018.
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This book highlights the increase in thyroid tumors and NET and demonstrates the growing importance of circulating markers in diagnosis as well as treatment and follow-up. Dramatic technical improvements have heightened the clinical impact of well-established, conventional biochemical markers. In addition, more recent genetic and molecular approaches have provided innovative molecular markers. In this context, effective communication between clinicians and laboratory physicians/scientists is es…
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Other Authors
Giovanella, Luca
Responsibility
Luca Giovanella, editor
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2018
Physical Description
1 online resource (xii, 249 p.) : 41 illus., 30 illus. in color
ISBN
9783319625065
9783319625058 (print ed.)
9783319625072 (print ed.)
9783319873305 (print ed.)
Subjects (MeSH)
Biomarkers, Tumor
Neuroendocrine Tumors - diagnosis
Neuroendocrine Tumors - therapy
Thyroid Neoplasms - diagnosis
Thyroid Neoplasms - therapy
Specialty
Endocrinology
Medical Oncology
Abstract
This book highlights the increase in thyroid tumors and NET and demonstrates the growing importance of circulating markers in diagnosis as well as treatment and follow-up. Dramatic technical improvements have heightened the clinical impact of well-established, conventional biochemical markers. In addition, more recent genetic and molecular approaches have provided innovative molecular markers. In this context, effective communication between clinicians and laboratory physicians/scientists is essential in allowing all those involved to fully profit from these exciting advances. In this comprehensive, up-to-date book, authors from different laboratory and clinical areas link laboratory and clinical topics. Analytical problems such as interferences, false-negative and false-positive results are discussed in depth, and flow-charts offer insights into identifying and avoiding them. Illustrated clinical cases detail the clinical role and limitations of different tumor markers. Lastly, it explores health technology assessment and economic issues. This is a valuable resource for endocrinologists, oncologists, nuclear medicine physicians, scientists and technologists who want to keep abreast of the latest developments.
Contents
Part I. Pathology and Pathobiology -- 1. Pathology and Immunohistochemistry in Thyroid Tumors -- 2. Pathology of Neuroendocrine Neoplasms: Morphological, Immunophenotypical, and Circulating Molecular Markers -- 3. Circulating Biomarkers: Biological Basis, Methods, and Interpretation Criteria -- Part II. Differentiated Thyroid Cancer -- 4. Differentiated Thyroid Cancer: Diagnosis, Therapy, and Follow-Up -- 5. Thyroglobulin and Thyroglobulin Antibodies -- 6. Circulating Molecular Biomarkers in Thyroid Cancer -- 7. Circulating Epithelial Tumor Cells in Thyroid Carcinoma -- Part III. Medullary Thyroid Carcinoma -- 8. Medullary Thyroid Carcinoma (MTC): Diagnosis, Treatment and Follow-Up -- 9. Calcitonin and Carcinoembryonic Antigen for the Diagnosis and Management of Medullary Thyroid Carcinoma -- 10. Procalcitonin: Are We Ready for Clinical Use? -- Part IV. Aggressive and Rare Thyroid Carcinoma -- 11. Aggressive Variants of Thyroid Carcinoma -- 12. Circulating Mucins and Cytokeratins in Aggressive Thyroid Cancers -- Part V. Thyroid Biomarkers on Fine-Needle Washouts -- 13. Measurement of Thyroid Tumor Markers on Fine-Needle Washouts -- Part VI. Neuroendocrine Tumors -- 14. Neuroendocrine Tumours: Diagnosis, Therapy and Follow-up -- 15. Circulating Markers in Neuroendocrine Tumors -- 16. Neuroendocrine Gene Transcripts: The Role of Molecular Biomarkers in Diagnosis and Management.
Format
e-Book
Publication Type
Atlas
Location
Online
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Biomarkers for Endometriosis : State of the Art

https://libcat.nshealth.ca/en/permalink/provcat41842
Thomas D'Hooghe, editor. --Cham: Springer , 2017.
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This book presents an overview of the diagnostic performance of non- or semi-invasive tests for endometriosis in peripheral blood, endometrium, saliva, peritoneal fluid and urine. The value of existing and emerging systems biology technologies for biomarker development is addressed in several chapters on genetics, microarrays, proteomics and metabolomics. Although tests with high sensitivity and acceptable specificity have been developed, sometimes validated in independent populations and seem …
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Other Authors
D'Hooghe, Thomas
Responsibility
Thomas D'Hooghe, editor
Place of Publication
Cham
Publisher
Springer
Date of Publication
2017
Physical Description
1 online resource (xii, 267 pages) : 8 illus., 3 illus. in color
ISBN
9783319598567
9783319598543 (print ed.)
Subjects (MeSH)
Biomarkers
Endometriosis - diagnosis
Abstract
This book presents an overview of the diagnostic performance of non- or semi-invasive tests for endometriosis in peripheral blood, endometrium, saliva, peritoneal fluid and urine. The value of existing and emerging systems biology technologies for biomarker development is addressed in several chapters on genetics, microarrays, proteomics and metabolomics. Although tests with high sensitivity and acceptable specificity have been developed, sometimes validated in independent populations and seem promising, more research is needed to translate these data into clinical benefit for patients and coordinate efforts internationally to standarize analysis, reports and operating procedures. The gold standard to diagnose endometriosis is currently through laparoscopic inspection with histological confirmation, a surgical procedure with rare but significant potential risks for the patients. A non-invasive test for endometriosis would be critical for the early detection of endometriosis of symptomatic women with pelvic pain and/or subfertility with normal ultrasound. This would include nearly all cases of minimal-mild endometriosis, some cases of moderate-severe endometriosis without a clearly visible ovarian endometrioma and cases with pelvic adhesions and/or other pelvic pathology, who might benefit from surgery to improve pelvic pain and/or subfertility. Such a test would also be useful in symptomatic women with ultrasound imaging suspicious for endometriosis, since it may be difficult to differentiate an ovarian endometrioma from other ovarian cysts and since the quality of ultrasound imaging is highly variable worldwide.
Contents
Building Translational Research Infrastructure and Access to Expertise for Biomarker Discovery in Cancer -- Biomarkers of Endometrial Cancer -- Biomarker Development in Chronic Inflammatory Diseases -- Endometriosis and Diagnostic Delay: The Patient’s Perspective -- Genetic Biomarkers for Endometriosis -- Epidemiological and Clinical Risk Factors for Endometriosis -- Peripheral Blood Biomarkers for Endometriosis -- Biomarkers for Endometriosis in Saliva, Urine, and Peritoneal Fluid -- mRNA and miRNA Biomarkers for Endometriosis -- Proteomic Biomarkers for Endometriosis -- Harmonization of Clinical and Laboratory Data to Improve Biomarker Discovery in Endometriosis: WERF EPHect -- OMICs Studies and Endometriosis Biomarker Identification.
Format
e-Book
Location
Online
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Biomarkers in Cancer Therapy : Liquid Biopsy Comes of Age

https://libcat.nshealth.ca/en/permalink/provcat44460
Hideaki Shimada, editor. --Singapore: Springer , 2019.
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This book sheds new light on research into liquid biopsy biomarkers for cancer screening. The chapters in the first half address exosomes, circulating cell-free DNA and autoantibodies, and main solid cancers, along with companion biomarkers – all of which serve as the basis for exploring key research questions for future clinical trials in the book’s second half. The study of biomarkers has evolved rapidly thanks to advances in precision medicine. While conventional cancer biomarker research is…
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Other Authors
Shimada, Hideaki
Responsibility
Hideaki Shimada, editor
Place of Publication
Singapore
Publisher
Springer
Date of Publication
2019
Physical Description
1 online resource (viii, 157 p.) : 22 illus., 17 illus. in color
ISBN
9789811372957
9789811372940 (Print ed.)
9789811372964 (Print ed.)
9789811372971 (Print ed.)
Subjects (MeSH)
Biomarkers
Liquid Biopsy
Neoplasms - diagnosis
Specialty
Clinical Laboratory Techniques
Medical Oncology
Abstract
This book sheds new light on research into liquid biopsy biomarkers for cancer screening. The chapters in the first half address exosomes, circulating cell-free DNA and autoantibodies, and main solid cancers, along with companion biomarkers – all of which serve as the basis for exploring key research questions for future clinical trials in the book’s second half. The study of biomarkers has evolved rapidly thanks to advances in precision medicine. While conventional cancer biomarker research is focused on proteomics or gene analysis of resected tissue, diagnostic markers have since become significant in terms of gauging the effectiveness of molecularly targeted drugs or the likelihood of a favorable prognosis. In addition, conventional treatment strategy, which draws on archives of resected tissue samples, is now gradually being replaced by monitoring with the use of liquid biopsy, which is poised to become the new mainstream in molecular targeting therapy. The contributing authors discuss in detail biomarkers, molecular targets for treatment, monitoring markers to evaluate treatment responses, prognostic markers, and screening and early diagnosis. Accordingly, this excellent collection of texts will benefit not only oncologists, but also medical and biological researchers and pharmaceutical scientists involved in the latest cancer research.
Contents
Part I. Various Strategies to Detect Cancer -- 1. Liquid Biopsy Diagnostics Using Extracellular Vesicles -- 2. Cell-Free DNA -- 3. Autoantibody in Cancer -- 4. Serum Angiogenic Factors as Cancer Biomarkers -- 5. Biomarkers of Cancer Stem Cells in Cancer Therapy -- Part II. Biomarkers for Individual Cancers -- 6. Specifics 1: Head and Neck Cancer and Esophageal Cancer -- 7. Biomarkers in Gastric Cancer -- 8. Liquid Biopsy in Hepatocellular Carcinoma -- 9. Biomarkers of Pancreatic Cancer -- 10. Biomarkers of Lung Cancer: Liquid Biopsy Comes of Age -- 11. Biomarkers for Breast Cancer Treatment -- 12. Biomarkers of Prostate Cancer -- 13. Biomarkers of Gynecological Cancers -- 14. Biomarkers of Malignant Pleural Mesothelioma.
Format
e-Book
Location
Online
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Biomarkers in Inflammatory Bowel Diseases

https://libcat.nshealth.ca/en/permalink/provcat44481
Nik Sheng Ding, Peter De Cruz, editors. --Cham: Springer , c2019.
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This book provides a comprehensive and complete overview of biomarkers in clinical practice for inflammatory bowel disease (IBD) bringing together the literature in a clear and concise manner. The book bridges the gap between growing knowledge at the bench and current and future applications of biomarkers in clinical practice. The central structure of the book focuses on prognostic and predictive biomarkers in IBD with an emphasis on the fields of research and scientific techniques (genomics, p…
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Other Authors
Sheng Ding, Nik
De Cruz, Peter
Responsibility
Nik Sheng Ding, Peter De Cruz, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2019
Physical Description
1 online resource (xvii, 365 p.) : 35 illus., 30 illus. in color
ISBN
9783030114466
9783030114459 (Print ed.)
9783030114473 (Print ed.)
Subjects (MeSH)
Biomarkers
Inflammatory Bowel Diseases - diagnosis
Specialty
Clinical Laboratory Techniques
Gastroenterology
Abstract
This book provides a comprehensive and complete overview of biomarkers in clinical practice for inflammatory bowel disease (IBD) bringing together the literature in a clear and concise manner. The book bridges the gap between growing knowledge at the bench and current and future applications of biomarkers in clinical practice. The central structure of the book focuses on prognostic and predictive biomarkers in IBD with an emphasis on the fields of research and scientific techniques (genomics, proteomics and metabonomics) that have led to biomarker discovery and places these biomarkers within a clinical context to help understand their utility in clinical practice. This book will be of use to clinicians who have an interest in using biomarkers in clinical practice as well as clinician researchers and scientists involved in the biomarker research pipeline. The author team comprises experts from around the world in order to bring together the literature in an effort to inform clinicians and researchers about the current state-of-the art in biomarker discovery. It is intended to assist future research efforts and indicate how biomarkers might be best applied to clinical practice both at present and in the future.
Contents
1. Introduction -- Part I. Background to Biomarkers -- 2. Clinical Risk Factors: Lessons from Epidemiology -- 3. Disease Modification in Crohn’s Disease -- 4. Personalized Medicine - Dream or Reality? -- 5. Clinical Trial Design to Facilitate Biomarker Discovery -- Part II. Clinical Algorithms Incorporating Predictive and Prognostic Biomarkers: Crohn’s Disease -- 6. Luminal Crohn’s Disease -- 7. Fibrosis and Stricturing Disease in Crohn’s Disease -- 8. Postoperative Crohn’s Disease -- 9. Perianal Crohn’s Disease -- Part III. Clinical Algorithms Incorporating Predictive and Prognostic Biomarkers: Ulcerative Colitis -- 10. Biomarkers in Acute Severe Ulcerative Colitis -- 11. Chronic Active Ulcerative Colitis -- 12. Refractory Proctitis -- 13. UC Surveillance -- 14. The Role of Biomarkers in the Ileal Anal Pouch -- Part IV. Clinical Algorithms Incorporating Predictive and Prognostic Biomarkers: Specialised Scenarios -- 15. Extra-intestinal Manifestations in Inflammatory Bowel Disease: Diagnosis and Management -- 16. Primary Sclerosing Cholangitis Overlapping with IBD -- 17. Pregnancy and IBD -- 18. Nutrition in IBD -- 19. Therapeutic Drug Monitoring in Inflammatory Bowel Disease: Optimising Therapeutic Effectiveness of Thiopurines -- 20. Therapeutic Drug Monitoring in Inflammatory Bowel Disease: Optimising Therapeutic Effectiveness of Biologics -- 21. Drug Toxicity: Personalising IBD Therapeutics–The Use of Genetic Biomarkers to Reduce Drug Toxicity -- 22. Biomarkers for Remote Monitoring -- Part V. Scientific Platforms for Biomarker Discovery -- 23. Exposome and Diet -- 24. The Microbiome in IBD -- 25. Metabolic Profiling in IBD -- 26. Innate and Adaptive Immunology -- 27. Genetic and Genomic Markers for Prognostication -- 28. Risk Alleles for Drug Targets: Genomic Markers of Drug Response -- Part VI. Conclusion -- 29. Big Data Meets Real World! The Use of Clinical Informatics in Biomarker Research -- 30. Bringing It Altogether: A Systems Biology Approach to Biomarkers in Inflammatory Bowel Disease.
Format
e-Book
Location
Online
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Biomarkers in Neoplastic Neuropathology

https://libcat.nshealth.ca/en/permalink/provcat39834
Fausto Rodriguez, Cheng-Ying Ho. --Cham: Springer , c2016.
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This book is a rich source of information on biomarkers applicable to the pathology of neoplastic disorders of the brain. Thorough descriptions are provided of the techniques currently available for clinical and experimental evaluation of biomarkers in brain neoplasms, including in situ hybridization, array-based methods, methylation profiling, next-generation sequencing, and practical gene panels. Incorporation of multiple biomarkers in the development of molecular subgroups with biologic and …
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Author
Rodriguez, Fausto
Other Authors
Ho, Cheng-Ying
Responsibility
Fausto Rodriguez, Cheng-Ying Ho
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2016
Physical Description
1 online resource (x, 98 p. : 31 illus., 1 illus. in color)
ISBN
9783319209319
9783319209302 (print ed.)
Subjects (MeSH)
Biomarkers, Tumor
Nervous System Neoplasms - physiopathology
Abstract
This book is a rich source of information on biomarkers applicable to the pathology of neoplastic disorders of the brain. Thorough descriptions are provided of the techniques currently available for clinical and experimental evaluation of biomarkers in brain neoplasms, including in situ hybridization, array-based methods, methylation profiling, next-generation sequencing, and practical gene panels. Incorporation of multiple biomarkers in the development of molecular subgroups with biologic and therapeutic relevance is also discussed. A section on biobanking covers the equally important topic of optimal preservation of tissue and includes consideration of ethical considerations raised by the use of tissue obtained in clinical settings. The closing section discusses the major categories of neoplastic disorders involving the nervous system, with emphasis on diagnostic, prognostic, and predictive biomarkers used in the pathologic evaluation of different types of brain tumor.
Contents
Introduction -- Special Techniques -- Biobanking and Regulations -- Public Databases -- Biomarkers applied to specific tumor types.
Format
e-Book
Location
Online
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Biomarkers in Periodontal Health and Disease : Rationale, Benefits, and Future Directions

https://libcat.nshealth.ca/en/permalink/provcat44899
Nurcan Buduneli. --Cham: Springer , c2020.
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This book examines all aspects of the progress being made towards the development of highly specific and sensitive biomarkers that will overcome the shortcomings of clinical assessments in periodontics. The opening chapters present the basic anatomic features of periodontal tissues, outline the nature and pathogenic mechanisms of periodontal diseases, and discuss both conventional and novel methods of diagnosis with reference to their specificity and sensitivity. The potential role of biomarker…
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Author
Buduneli, Nurcan
Responsibility
Nurcan Buduneli
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2020
Physical Description
1 online resource (xv, 90 p.) : 34 illus., 33 illus. in color
ISBN
9783030373177
9783030373153 (Print ed.)
9783030373160 (Print ed.)
Subjects (MeSH)
Biomarkers
Periodontal Diseases - diagnosis
Specialty
Dentistry
Diagnosis
Oral Health
Abstract
This book examines all aspects of the progress being made towards the development of highly specific and sensitive biomarkers that will overcome the shortcomings of clinical assessments in periodontics. The opening chapters present the basic anatomic features of periodontal tissues, outline the nature and pathogenic mechanisms of periodontal diseases, and discuss both conventional and novel methods of diagnosis with reference to their specificity and sensitivity. The potential role of biomarkers in periodontal diagnosis is then presented in the light of the published data. The biological samples in which potential biomarkers are sought are evaluated comparatively, drawing attention to their strengths and weaknesses, and the available technologies for biomarker studies are reviewed. The potential benefits of biomarkers are also discussed with regard to the possible bidirectional interactions between periodontal diseases and systemic health. Finally, the past, present, and future of periodontics are examined from a broader perspective. Readers will find the book to be an ideal summary of the state of the art in the field as biomarkers emerge that promise to facilitate periodontal diagnostics and permit timely, personally tailored interventions.
Contents
1. Anatomy of Periodontal Tissues -- 2. Nature of Periodontal Diseases -- 3. Conventional Diagnosis of Periodontal Diseases and 2017 Classification System -- 4. Novel Diagnostic Approaches in Periodontics -- 5. Biomarkers for Periodontal Diseases -- 6. Biological Samples for Biomarkers: Strengths and Weaknesses -- 7. Technologies for Biomarkers in Periodontics -- 8. Biomarkers in Periodontal Disease and Systemic Health Intersection -- 9. Past, Present and Future of Periodontics.
Format
e-Book
Location
Online
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Biomarkers of Cardiometabolic Risk, Inflammation and Disease

https://libcat.nshealth.ca/en/permalink/provcat39237
Filipe Palavra, Fl©vio Reis, Daniela Marado, Armando Sena, editors. --Cham: Springer , c2015.
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This book discusses recent advances in the area of cardiometabolic risk biomarkers of chronic inflammatory and cardiovascular disorders. Tackling the topic in a systematic manner, the book starts with an introduction to cardiometabolic risk and its clinical relevance, comparing emergent and classical biomarkers. It then goes on to discuss cardiometabolic risk biomarkers in a range of diseases, including diabetes, ischemic stroke and neurodegenerative disorders. Biomarkers of Cardiometabolic Ris…
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Other Authors
Palavra, Filipe
Reis, Fl©vio
Marado, Daniela
Sena, Armando
Responsibility
Filipe Palavra, Fl©vio Reis, Daniela Marado, Armando Sena, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2015
Physical Description
1 online resource (x, 165 p. : 11 illus. in color)
ISBN
9783319160184
9783319160177 (print ed.)
Subjects (MeSH)
Biomarkers
Cardiovascular Diseases - diagnosis
Inflammation
Risk Factors
Abstract
This book discusses recent advances in the area of cardiometabolic risk biomarkers of chronic inflammatory and cardiovascular disorders. Tackling the topic in a systematic manner, the book starts with an introduction to cardiometabolic risk and its clinical relevance, comparing emergent and classical biomarkers. It then goes on to discuss cardiometabolic risk biomarkers in a range of diseases, including diabetes, ischemic stroke and neurodegenerative disorders. Biomarkers of Cardiometabolic Risk, Inflammation and Disease is aimed at doctors specializing in internal medicine, neurology, cardiology, rheumatology, nephrology or endocrinology and will also be of interest to GPs, trainee doctors, and clinical and basic researchers working on cardiovascular and autoimmune disorders.
Contents
Inflammation biomarkers and cardiometabolic risk -- Cardiovascular disease -- Diabetes mellitus and metabolic syndrome -- Ischemic stroke -- Chronic kidney disease -- Immune-mediated inflammatory rheumatic diseases -- Cardiometabolic risk, inflammation and neurodegenerative disorders.
Format
e-Book
Location
Online
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Biomarkers of kidney disease

https://libcat.nshealth.ca/en/permalink/provcat43556
Edelstein, Charles. (2nd ed.) --Amsterdam: Elsevier/Academic Press , 2017.
Access
Access to this online resource is restricted to IWK Health Centre employees working from inside the hospital network.
Location
Online
Author
Edelstein, Charles
Edition
2nd ed.
Place of Publication
Amsterdam
Publisher
Elsevier/Academic Press
Date of Publication
2017
Physical Description
online resource
ISBN
9780128030141
Subjects (MeSH)
Kidney Diseases - diagnosis
Biomarkers
Access
Access to this online resource is restricted to IWK Health Centre employees working from inside the hospital network.
Format
e-Book
Location
Online
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Biomarkers of the Tumor Microenvironment : Basic Studies and Practical Applications

https://libcat.nshealth.ca/en/permalink/provcat41337
Lars A. Akslen, Randolph S. Watnick, editors. --Cham: Springer , 2017.
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This book reviews different aspects of the cancer microenvironment, and its regulation and importance for tumor progression. Practical applications, in terms of how biomarkers are increasingly included in therapy protocols, will also be discussed. Biomarkers of the Tumour Microenvironment: Basic Studies and Practical Applications is aimed at research pathologists in the cancer field, and also cancer researchers from other backgrounds, especially those using morphology techniques and models focu…
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Other Authors
Akslen, Lars A
Watnick, Randolph S
Responsibility
Lars A. Akslen, Randolph S. Watnick, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
2017
Physical Description
1 online resource (xvii, 534 pages) : 52 illus., 51 illus. in color
ISBN
9783319391472
9783319391458 (print ed.)
Subjects (MeSH)
Biomarkers, Tumor
Tumor Microenvironment
Abstract
This book reviews different aspects of the cancer microenvironment, and its regulation and importance for tumor progression. Practical applications, in terms of how biomarkers are increasingly included in therapy protocols, will also be discussed. Biomarkers of the Tumour Microenvironment: Basic Studies and Practical Applications is aimed at research pathologists in the cancer field, and also cancer researchers from other backgrounds, especially those using morphology techniques and models focusing on cross-talk between different cell types in tumors.
Contents
Part I: Basic Mechanisms and Biomarkers -- 1. The Role of the Tumor Microenvironment in Regulating Angiogenesis -- 2. More Than a Barrier: How the Endothelium Instructs Metastasis -- 3. Tissue-Based Biomarkers of Tumor-Vascular Interactions -- 4. Role of the Extracellular Matrix in Tumor Stroma: Barrier or Support? -- 5. Stromal PDGF Receptors as Prognostic and Predictive Biomarkers -- 6. The Function and Diagnostic Potential of Adipocyte-Derived Factors in the Tumor Microenvironment -- 7. Inflammation and Cancer: The Role of Lipid Signaling in the Continuum Between Two Ends of the Tumor Spectrum -- 8. Cancer Immunity and Immune Evasion Mechanisms -- 9. Drivers of EMT and Immune Evasion -- 10. Inflammatory Biomarkers for Cancer -- 11. Immunology of Solid Tumors Beyond Tumor-Infiltrating Lymphocytes: The Role of Tertiary Lymphoid Structures -- 12. The Role of Platelets in the Tumor Microenvironment -- 13. Regulation of Tumor Progression and Metastasis by Bone Marrow-Derived Microenvironments -- 14. Neuropilin 1 and Neuropilin 2: Cancer Progression and Biomarker Analysis -- 15. The Role of Axl Receptor Tyrosine Kinase in Tumor Cell Plasticity and Therapy Resistance -- Part II: Organ Related Biomarker Studies -- 16. Gene Expression Signatures of the Tumor Microenvironment: Relation to Tumor Progress in Breast Cancer -- 17. MR-Derived Biomarkers for Cancer Characterization -- 18. The Influence of Tissue Architecture on Drug Response: Anticancer Drug Development in High-Dimensional Combinatorial Microenvironment Platforms -- 19. Models of Tumor Progression in Prostate Cancer -- 20. Tumor-Host Interactions in Malignant Gliomas -- 21. The Tumor Microenvironment in Cutaneous Melanoma: Friend or Foe -- 22. Biomarker Panels and Contemporary Practice in Clinical Trials of Targeted Therapy.
Format
e-Book
Location
Online
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Cancer Proteomics : From Bench to Bedside

https://libcat.nshealth.ca/en/permalink/provcat40631
edited by Sayed S. Daoud. --Totowa, NJ: Humana Press , c2008.
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Online
Over the past 20 years or so, there have been tremendous advances in our understanding of how normal cells transform to cancer and the importance of signaling pathways in cancer initiation and progression. Therefore, proteomics technologies must be improved for more global analysis of protein content of cells, tissues and body fluids as well as the posttranslational modifications to allow for proper detections and validation. In Cancer Proteomics, the authors collectively provide the current st…
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Other Authors
Daoud, Sayed S
Responsibility
edited by Sayed S. Daoud
Place of Publication
Totowa, NJ
Publisher
Humana Press
Date of Publication
c2008
Physical Description
1 online resource (xii, 264 p. : 5 illus. in color)
Series Title
Cancer drug discovery and development
ISBN
9781597451697
9781588298584 (print ed.)
Subjects (MeSH)
Antineoplastic Agents
Biomarkers, Tumor
Neoplasms
Proteomics - methods
Abstract
Over the past 20 years or so, there have been tremendous advances in our understanding of how normal cells transform to cancer and the importance of signaling pathways in cancer initiation and progression. Therefore, proteomics technologies must be improved for more global analysis of protein content of cells, tissues and body fluids as well as the posttranslational modifications to allow for proper detections and validation. In Cancer Proteomics, the authors collectively provide the current status of proteomics in cancer therapy and offers the existing technologies used in proteomics that allow for protein profiling and for the identification of druggable targets in human samples. Mass spectrometry based protein characterization and protein microarrays hold great promise of predicting response to specific drugs in cancer therapy. Insightful to the reader with broad perspectives on topics related to the use of proteomic strategies in cancer therapy, Cancer Proteomics offers anticipated challenges that may arise from its application in daily practice.
Contents
Part I. Proteomics Technologies -- Current and Emerging Mass Spectrometry Instrumentation and Methods for Proteomic Analyses -- Part II. Cell Signaling Proteomics -- Integration of Genomics and Proteomics in Dissecting p53 Signaling -- Proteomic Profiling of Tyrosine Kinases as Pharmacological Endpoints for Targeted Cancer Therapy -- Part III. Tumor Proteomics -- Oncoproteomics for Personalized Management of Cancer -- Application of Serum and Tissue Proteomics to Understand and Detect Solid Tumors -- Insight on Renal Cell Carcinoma Proteome -- Proteomics in Lung Cancer -- Proteomic Strategies of Therapeutic Individualization and Target Discovery in Acute Myeloid Leukemia -- New Tumor Biomarkers: Practical Considerations Prior to Clinical Application -- Part IV. Bioinformatics and Regulatory Aspects of Proteomics -- Annotating the Human Proteome: From Establishing a Parts List to a Tool for Target Identification -- Regulatory Issues in the Co-Development of Oncology Drugs and Proteomic Tests: An Overview.
Format
e-Book
Location
Online
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Cardiac Biomarkers : Case Studies and Clinical Correlations

https://libcat.nshealth.ca/en/permalink/provcat40319
Alan S. Maisel, Allan S. Jaffe, editors. --Cham: Springer , c2016.
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This book presents a comprehensive compendium of case studies to inform clinicians how to optimally deploy the major clinically utilized biomarkers in cardiology. Biomarkers now play an integral role in the treatment and management of patients with congestive heart failure and acute ischemic heart disease because they provide crucial information about the status of individual patients. For that reason, it is important for clinicians to understand the basis for the use of these markers. Every re…
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Other Authors
Maisel, Alan S
Jaffe, Allan S
Responsibility
Alan S. Maisel, Allan S. Jaffe, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2016
Physical Description
1 online resource (xviii, 370 p. : 56 illus., 40 illus. in color)
ISBN
9783319429823
9783319429809 (print ed.)
Subjects (MeSH)
Biomarkers
Heart Failure
Myocardial Ischemia
Natriuretic Peptides - therapeutic use
Troponin - therapeutic use
Abstract
This book presents a comprehensive compendium of case studies to inform clinicians how to optimally deploy the major clinically utilized biomarkers in cardiology. Biomarkers now play an integral role in the treatment and management of patients with congestive heart failure and acute ischemic heart disease because they provide crucial information about the status of individual patients. For that reason, it is important for clinicians to understand the basis for the use of these markers. Every reader may not have the laboratory and/or clinical expertise to understand all the details associated with the use of these markers, which is why this book takes a case oriented approach and by doing so provides a practical resource to guide the clinician through the options available. Cardiac Biomarkers discusses how to use these biomarkers optimally and, in particular, how to understand when values provide actionable information. The book an essential guide for all physicians and healthcare practitioners in the field of cardiology.
Contents
[publisher supplied] The patient with chest pain: The troponin story -- Troponin Basics for the clinician -- Pathophysiology of trop I and T in myocardial ischemia/infarction -- International Definition of MI- rationale and practice -- Evaluation of patients presenting with chest pain- where do troponins fit in -- Using contemporary troponin in patients with AMI -- Using troponins to guide therapy in ACS -- Use of cTn in patients with heart failure -- Elevated cTn in other acute situations -- Use of cTn for detection of more chronic disease states -- High sensitivity assays- what are they and why do we need them -- Use of troponin for the evaluation of patients potentially at risk for cardiovascular disease -- Gaps in our biomarker armamentarium: what novel biomarkers might be synergistic in patients with acute disease -- The patient with shortness of breath: the natriuretic peptide story -- Evaluation of patients presenting with sob- where do nps fit in -- Pathophysiology of bnp, and ntpro bnp -- A clinicians guide to lab assays for nps -- Using NPS in the ED- diagnosis -- Using NPs in the ED- algorithms and risk stratification -- Using NPs in the hospital -- NPs at the time of discharge -- Finger stick NP levels at home -- Guiding therapy of heart failure with NPs -- Caveats to NP measurement -- Other biomarkers for heart failure -- Biomarkers of cardiorenal disease -- Biomarkers of cardiac risk.
Format
e-Book
Publication Type
Case Reports
Location
Online
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Damage-Associated Molecular Patterns in Human Diseases : Volume 1. Injury-Induced Innate Immune Responses

https://libcat.nshealth.ca/en/permalink/provcat42536
Walter Gottlieb Land. --Cham: Springer , c2018.
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This book presents current understanding of the importance of modern immunology in the etiopathogenesis of human diseases and explores how this understanding is impacting on diagnosis, prognosis, treatment, and prophylaxis. As the core of modern immunology, the "danger/injury model" is introduced and addressed throughout the book. Volume I of the book describes the network of damage-associated molecular pattern molecules (DAMPs) and examines the central role of DAMPs in cellular stress response…
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Author
Land, Walter Gottlieb
Responsibility
Walter Gottlieb Land
Alternate Title
Injury-induced innate immune responses
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2018
Physical Description
1 online resource (xlviii, 870 p.) : 115 illus., 102 illus. in color
ISBN
9783319786551
9783319786544 (print ed.)
9783319786568 (print ed.)
Subjects (MeSH)
Biomarkers - analysis
Immunologic Techniques
Molecular Medicine
Pathogen-Associated Molecular Pattern Molecules
Stress, Physiological - immunology
Wounds and Injuries - immunology
Specialty
Diagnosis
Molecular Medicine
Pathology
Abstract
This book presents current understanding of the importance of modern immunology in the etiopathogenesis of human diseases and explores how this understanding is impacting on diagnosis, prognosis, treatment, and prophylaxis. As the core of modern immunology, the "danger/injury model" is introduced and addressed throughout the book. Volume I of the book describes the network of damage-associated molecular pattern molecules (DAMPs) and examines the central role of DAMPs in cellular stress responses and associated regulated cell death, the promotion and resolution of inflammation, the activation of innate lymphoid cells and unconventional T cells, the stimulation of adaptive immunity, and tissue repair. The significance of DAMPs in a wide range of human diseases will then be explored in Volume II of the book, with discussion of the implications of injury-induced innate immunity for present and future treatments. This book is written for professionals from all medical and paramedical disciplines who are interested in the introduction of innovative data from immunity and inflammation research into clinical practice. The readership will include practitioners and clinicians such as hematologists, rheumatologists, traumatologists, oncologists, intensive care anesthetists, endocrinologists such as diabetologists, psychiatrists, neurologists, pharmacists, and transplantologists.
Contents
Part I. The Three Major Paradigms in Modern Immunology -- Prologue: The Term "Immunity" over the Course of Time -- The Three Major Paradigms in Immunology -- Epilogue: What Major Paradigm in Immunology Comes Next? -- Part II. The Innate Immune System: an Organ of Perception Determined to Maintain Homeostasis -- Prologue: The Guardians of Homeostasis -- Innate Immune Recognition Molecules -- Epilogue: The Innate Immune System: a Global Player in Health and Disease -- Part III. The Whole Family of Mammalian Innate Immune Cells -- Prologue: The Whole Body as an Immune System? -- Mobile Innate Immune Cells -- Sessile Innate Immune Cells -- Epilogue: The Whole Body as an Immune Defence System -- Part IV. The World of DAMPs. Prologue: About DAMPs, PAMPs and MAMPs -- Endogenous DAMPs, Category I: Constitutively Expressed Native Molecules (Cat. I DAMPs) -- Endogenous DAMPs, Category II: Constitutively Expressed, Injury-Modified Molecules (Cat. II DAMPs) -- Endogenous DAMPs, Category III: Inducible DAMPs (Cat. III DAMPs) -- Exogenous DAMPs, Category IV (Cat. IV DAMPs) -- Epilogue: The Well-Dosed Work of DAMPs in their Commission to Restore and Maintain Homeostasis -- Part V. Cellular Stress Responses and Regulated Cell Death -- Prologue: Innate Immune Tools to Defend against Stressful Injury: Success and Failure -- Cell-Autonomous (Cell-Intrinsic) Stress Responses -- Regulated Cell Death -- Epilogue: The Horror of an Injury-Induced Avalanche of DAMPs -- Part VI. Innate Immune Effector Responses -- Prologue: The Various Facets of Innate Immune Effector Responses -- Cellular Inflammatory Responses -- Humoral Innate Immune Effector Responses -- Regulation of Innate Inflammatory Responses -- Epilogue to Part VI -- Part VII. Function of Innate Lymphoid Cells and Unconventional T Cells with Partial Innate Function -- Prologue: The "Ready-to-Go" Lymphocytes of the Immune System -- Activating and Function of Innate Lymphoid Cells -- Activating and Function of Unconventional T Cells -- Epilogue: Killer Lymphocytes as Tools for Future Immunotherapeutic Approaches -- Part VIII. DAMPs Promoting Adaptive Immunity and Tissue Repair -- Prologue: The "Long Arm" of DAMPs in Shaping Adaptive Immune Responses and Tissue Repairing Processes -- Antigen Uptake, Processing and Presentation by Dendritic Cells -- Antigen in the Presence of DAMPs Induces Immunostimulatory Dendritic Cells to Promote "Destructive" Acquired Immune Responses -- Antigen in the Absence of DAMPs Promotes Immunotolerance: the Role of Dendritic Cells and Regulatory T Cells -- An Impressive Example of Peripheral Tolerance against Nonself: Tolerance to Commensal Bacterial and Dietary Protein Antigens -- Immunometabolism of Dendritic Cells and T Cells -- Role of DAMPs in Tissue Regeneration and Repair -- Epilogue: DAMPs as Key Players in the Pathogenesis of Many Human Diseases.
Format
e-Book
Location
Online
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Damage-Associated Molecular Patterns in Human Diseases : Volume 2: Danger Signals as Diagnostics, Prognostics, and Therapeutic Targets

https://libcat.nshealth.ca/en/permalink/provcat45638
Walter Gottlieb Land. --Cham: Springer , c2020.
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This book is a continuance of the topic: “DAMPs in Human Diseases”, the basics of which were described in a first volume by the same author. This second volume presents our current understanding of the impact of sterile stress/injury-induced innate immune responses on the etiopathogenesis of human diseases by focusing on those diseases that are pathogenetically dominated by DAMPs, i.e., on polytrauma, various solid organ injuries (brain, lung, kidney, liver), atherosclerosis, and cerebro-cardio…
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Author
Land, Walter Gottlieb
Responsibility
Walter Gottlieb Land
Alternate Title
Danger signals as diagnostics, prognostics, and therapeutic targets
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2020
Physical Description
1 online resource (xxxix, 629 p.) : 45 illus. in color
ISBN
9783030538682
9783030538675 (Print ed.)
9783030538699 (Print ed.)
9783030538705 (Print ed.)
Subjects (MeSH)
Biomarkers
Immunologic Techniques
Molecular Medicine
Pathogen-Associated Molecular Pattern Molecules
Stress, Physiological - immunology
Wounds and Injuries - immunology
Specialty
Diagnosis
Molecular Medicine
Pathology
Abstract
This book is a continuance of the topic: “DAMPs in Human Diseases”, the basics of which were described in a first volume by the same author. This second volume presents our current understanding of the impact of sterile stress/injury-induced innate immune responses on the etiopathogenesis of human diseases by focusing on those diseases that are pathogenetically dominated by DAMPs, i.e., on polytrauma, various solid organ injuries (brain, lung, kidney, liver), atherosclerosis, and cerebro-cardiovascular diseases. Our growing understanding of the pathogenetic function of activating DAMPs and suppressive DAMPs (“SAMPs”) is used as a point of departure to explore how these molecules can be used as biomarkers to extend and improve current diagnostic and prognostic modalities. Moreover, this new knowledge about the pathogenetic function of DAMPs and SAMPs is taken as a sound and plausible reason for discussing their implications for present and future treatment of the diseases addressed here. In this context, the focus is on the potential of DAMPs as future therapeutic targets and SAMPs as future therapeutics, applied in strict compliance with safety precautions, as also recommended in this work. The book is intended for professionals from all medical and paramedical disciplines who are interested in applying innovative data from inflammation and immunity research to clinical practice. The readership will include practitioners and clinicians working in the broad field of acute and chronic inflammatory/fibrotic diseases, in particular, traumatologists and intensivists; neurologists and neurosurgeons; cardiologists and cardiac surgeons; pulmonologists and thoracic surgeons; vascular surgeons; nephrologists; gastroenterologists and hepatologists; and pharmacists. Also available: Damage-Associated Molecular Patterns in Human Diseases, Vol. 1: Injury-Induced Innate Immune Responses.
Contents
Part I. Prologue -- Perspectives of the Danger/Injury Model in Immunology -- Part II. A Select, Clinically Oriented Update of Topics Presented in “Damage-Associated Molecular Patterns in Human Diseases, Volume 1: Injury-Induced Innate Immune Responses" -- Pattern Recognition Molecules -- The Growing World of DAMPs -- The Growing Clinical Relevance of Cellular Stress Responses and Regulated Cell Death -- DAMP-Promoted Efferent Innate Immune Responses in Human Diseases: Inflammation -- DAMP-Promoted Efferent Innate Immune Responses in Human Diseases: Fibrosis -- Part III. DAMPs and SAMPs in Traumatic Disorders, Atherosclerosis, and Cerebro-Cardiovascular Diseases -- DAMPs and SAMPs as Molecular Biomarkers, Therapeutic Targets, and Therapeutics -- DAMP-Controlled and Uncontrolled Responses to Trauma: Wound Healing and Polytrauma -- Solid Organ Injury -- Atherosclerosis -- Cerebro - Cardiovascular Diseases -- Part IV. Epilogue -- The “DAMPome” as a Key Player in the Pathogenesis of Human Diseases.
Format
e-Book
Location
Online
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Diagnosis of Blood and Bone Marrow Disorders

https://libcat.nshealth.ca/en/permalink/provcat42790
Sa A. Wang, Robert P. Hasserjian, editors. --Cham: Springer , c2018.
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This book focuses on hematopoietic and lymphoid neoplasms that initially present as peripheral blood abnormalities, with either cytopenias or elevated peripheral blood counts, as well as non-neoplastic conditions that may raise concern for a hematologic malignancy. The scope of the book includes myelodysplastic syndromes (MDS), myeloproliferative neoplasms (MPN), mixed myelodysplastic/myeloproliferative neoplasms (MDS/MPN), as well as lymphomas and lymphoid leukemias that typically present init…
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Other Authors
Wang, Sa A.
Hasserjian, Robert P.
Responsibility
Sa A. Wang, Robert P. Hasserjian, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2018
Physical Description
1 online resource (ix, 412 p.) : 218 illus., 217 illus. in color
ISBN
9783319202792
9783319202785 (print ed.)
9783319202808 (print ed.)
Subjects (MeSH)
Biomarkers
Bone Marrow Diseases - diagnosis
Hematologic Diseases - diagnosis
Hematologic Neoplasms - diagnosis
Hematopoietic Stem Cells
Specialty
Hematology
Abstract
This book focuses on hematopoietic and lymphoid neoplasms that initially present as peripheral blood abnormalities, with either cytopenias or elevated peripheral blood counts, as well as non-neoplastic conditions that may raise concern for a hematologic malignancy. The scope of the book includes myelodysplastic syndromes (MDS), myeloproliferative neoplasms (MPN), mixed myelodysplastic/myeloproliferative neoplasms (MDS/MPN), as well as lymphomas and lymphoid leukemias that typically present initially with peripheral blood abnormalities. Within each category, a comprehensive list of differential diagnoses is discussed. For each disease entity, the reader is updated with new molecular genetic data, biomarkers, and recent applications of immunophenotyping, and how to incorporate the new information in disease diagnosis and classifications is illustrated, including the use of diagnostic algorithms where appropriate. The book employs the revised WHO Classification of Hematopoietic Neoplasms for all disease entities. Diagnosis of Blood and Bone Marrow Disorders will serve as a very useful resource for pathologists, pathologists in training, hematologists and medical technologists who are involved in the clinical work-up of patients with bone marrow and blood neoplasms. It will provide a practical and concise yet comprehensive review.
Contents
1. Identifying Blood and Bone Marrow Abnormalities in the Laboratory -- 2. Cytopenias: Reactive and Neoplastic -- 3. Inherited Bone Marrow Failure Syndromes, Myeloid Neoplasms with Germline Predisposition and Myeloid Proliferations Associated with Down Syndrome -- 4. Cytopenias: Acquired Bone Marrow Failure -- 5. Leukocytosis: Neutrophilia, Basophilia, and Blasts -- 6. Leukocytosis: Eosinophilia -- 7. Monocytosis -- 8. Thrombocytosis -- 9. Erythrocytosis -- 10. Mixed Cytoses and Cytopenias -- 11. T- and NK-Cell Lymphocytosis -- 12. B-Cell Lymphocytosis -- 13. Multiple Myeloma and Other Plasma Cell Neoplasms.
Format
e-Book
Location
Online
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Gastric Cancer In The Precision Medicine Era : Diagnosis and Therapy

https://libcat.nshealth.ca/en/permalink/provcat44285
Vincenzo Canzonieri, Antonio Giordano, editors. --Cham: Humana Press , 2019.
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This book provides a comprehensive, state-of-the art review and serves as an overview of the different aspects of gastric cancer. The first section aims to clarify the main aspects of tumorigenesis, such as the role of inflammation linked to the presence of H. Pylori infection, and the genetic and epigenetic mechanisms so far known. Secondly, an exhaustive overview of the diagnosis of gastric cancer from a clinical/endoscopic and pathologic perspective will be illustrated. The second section in…
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Other Authors
Canzonieri, Vincenzo
Giordano, Antonio
Responsibility
Vincenzo Canzonieri, Antonio Giordano, editors
Place of Publication
Cham
Publisher
Humana Press
Date of Publication
2019
Physical Description
1 online resource (xv, 256 p.: 47 illus. in color
Series
Current Clinical Pathology
Series Title
Current clinical pathology
ISBN
9783030048617
9783030048600 (Print ed.)
9783030048624 (Print ed.)
ISSN
2197-781X
Subjects (MeSH)
Biomarkers
Precision Medicine
Stomach Neoplasms - diagnosis
Stomach Neoplasms - therapy
Specialty
Gastroenterology
Medical Oncology
Precision Medicine
Abstract
This book provides a comprehensive, state-of-the art review and serves as an overview of the different aspects of gastric cancer. The first section aims to clarify the main aspects of tumorigenesis, such as the role of inflammation linked to the presence of H. Pylori infection, and the genetic and epigenetic mechanisms so far known. Secondly, an exhaustive overview of the diagnosis of gastric cancer from a clinical/endoscopic and pathologic perspective will be illustrated. The second section includes the pathological and clinical features and contains information regarding the most recent tissue and serological biomarkers in these neoplasms. The three successive sections are intended to provide the “state of art” of multimodal treatment approaches to gastric cancer, i.e. standard and novel surgical aspects, common and innovative chemo and radio protocols and modern targeted therapies. Novel molecular classifications are under consideration to improve diagnostic and prognostic definitions and to prospect future treatments based on the use of immunotherapies and innovative molecules such as non-coding RNA and nanoparticles. Gastric Cancer in the Precision Medicine Era serves as a useful resource for physicians and researchers dealing with, and interested in, this challenging malignancy. It provides a concise yet comprehensive summary of the current status of the field that helps guide patient management and stimulates investigative efforts. All chapters are written by experts in their fields and includes the most up to date scientific and clinical information.
Contents
Part I. Gastric Tumorigenesis -- Gastric Tumorigenesis: Role of Inflammation and Helicobacter Pylori -- Genetic and Epigenetic Mechanisms in Gastric Cancer -- Part II. Clinical and Pathological Characteristics -- Diagnosis and Surveillance: Endoscopic Hallmarks -- Pathological Diagnosis And Classification Of Gastric Epithelial Tumors -- Diagnostic, Prognostic, Predictive and Therapeutic Tissue Biomarkers in Gastric Cancer -- Serum Biomarkers in Gastric Cancer -- Part III. Gastric Cancer Therapy: Multimodal Treatment Approach -- New Agents in the Treatment of Advanced Gastric Cancer: Targeted Therapy and Immunotherapy -- Combined-Modality Treatment for Locally Advanced Gastric Cancer: Current Evidences and New Perspectives -- Surgical Strategies in Gastric Cancer -- Part IV. Evolving Treatment Landscape in Gastric Cancer -- From Molecular Classification to Targeted Therapy for Gastric Cancer in the Precision Medicine Era -- Part V. Future Medicine in Gastric Cancer -- Non-Coding RNA in Gastric Cancer with Potential Prognostic and Predictive Role -- Immunomodulation and Immunotherapy for Gastric Cancer -- Nanomedicine in Gastric Cancer.
Format
e-Book
Location
Online
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Genomic Medicine : A Practical Guide

https://libcat.nshealth.ca/en/permalink/provcat44958
Laura J. Tafe, Maria E. Arcila, editors. --Cham: Springer , c2020.
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The field of Molecular Diagnostics is rapidly evolving and molecular characterization of neoplasms is becoming an increasingly important part of the pathologic work up and diagnosis of many tumor types. This work provides a high-yield reference book that compiles critical information related to molecular biomarkers for various solid tumor and hematologic malignancy subtypes. It is succinct yet comprehensive enough to be suitable for fellows in training and medical professionals with an interest…
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Other Authors
Tafe, Laura J.
Arcila, Maria E.
Responsibility
Laura J. Tafe, Maria E. Arcila, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2020
Physical Description
1 online resource (x, 325 p.) : 21 illus., 20 illus. in color
ISBN
9783030229221
9783030229214 (Print ed.)
9783030229238 (Print ed.)
Subjects (MeSH)
Biomarkers, Tumor
Molecular Diagnostic Techniques
Pathology, Molecular
Precision Medicine - methods
Specialty
Genetics, Medical
Abstract
The field of Molecular Diagnostics is rapidly evolving and molecular characterization of neoplasms is becoming an increasingly important part of the pathologic work up and diagnosis of many tumor types. This work provides a high-yield reference book that compiles critical information related to molecular biomarkers for various solid tumor and hematologic malignancy subtypes. It is succinct yet comprehensive enough to be suitable for fellows in training and medical professionals with an interest in molecular pathology and biomarkers. The book covers many aspects of molecular diagnostics, from techniques to applications and comprehensive summaries of the current molecular biomarkers of critical importance in solid and liquid tumors. Attention is also specifi cally devoted to bioinformatics and next generation sequencing, as well as pre-analytical issues that must be considered for accurate interpretation of molecular results in the context of overall patient care. This text focuses on clinical utility and validity and serves as an “owner’s manual” in Genomic Diagnostics for the practicing pathologist, pathology fellows and residents and other health care providers. Physicians will find this book invaluable as a quick reference for current molecular testing modalities and guidelines, tumor board preparation, deciding which test to order and interpreting genomic laboratory results. In addition, it is an accessible for trainees as a board review preparation reference.
Contents
Part I. General Concepts -- Pre-Analytics, Current Testing Technologies, and Limitations of Testing -- Next Generation Sequencing -- Cell-Free DNA Testing -- Role of Bioinformatics in Molecular Medicine -- Interpreting Genomic Reports -- Part II. Applications in Solid Tumors -- Lung Carcinoma -- GI including GIST -- Breast -- Genitourinary Tumors -- Gynecologic Malignancies -- Sarcomas -- Salivary Gland Carcinomas -- Sinonasal Carcinomas -- Part III. Applications in Hematopathology -- Acute Myeloid Neoplasms -- Chronic Myeloid Neoplasms -- Lymphomas.
Format
e-Book
Location
Online
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Hypertension and Organ Damage : A Case-Based Guide to Management

https://libcat.nshealth.ca/en/permalink/provcat39972
Giuliano Tocci. (1st ed.) --Cham: Springer , c2016.
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Online
This book is designed to assist physicians in choosing among diagnostic procedures and therapeutic options when caring for patients with hypertension and markers of organ damage. The comprehensive description of practical clinical cases sets this book apart from other publications and will help the reader to transfer general guideline recommendations to the clinical setting. With this purpose, the cases have been selected to reflect situations frequently encountered during clinical routine, rat…
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Author
Tocci, Giuliano
Responsibility
Giuliano Tocci
Edition
1st ed.
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2016
Physical Description
1 online resource (xiii, 119 p. : 60 illus., 30 illus. in color)
Series Title
Practical case studies in hypertension management
ISBN
9783319250977
9783319250953 (print ed.)
ISSN
2364-6632
Subjects (MeSH)
Antihypertensive Agents - therapeutic use
Biomarkers - metabolism
Comorbidity
Hypertension - complications
Hypertension - drug therapy
Abstract
This book is designed to assist physicians in choosing among diagnostic procedures and therapeutic options when caring for patients with hypertension and markers of organ damage. The comprehensive description of practical clinical cases sets this book apart from other publications and will help the reader to transfer general guideline recommendations to the clinical setting. With this purpose, the cases have been selected to reflect situations frequently encountered during clinical routine, rather than hypertensive crises or emergencies or the rare presentations that tend to be addressed in case reports in scientific journals. The scenarios considered include treated hypertension with uncontrolled blood pressure levels in patients with left ventricular hypertrophy, diastolic dysfunction, carotid atherosclerosis, microalbuminuria and renal impairment, proteinuria and renal disease, and abnormal pulse pressure. By representing clinical practice in a "real world" setting, these paradigmatic cases will enable the practitioner to select the diagnostic tools and form of treatment best suited to the individual patient and the particular cardiovascular risk profile, thereby optimizing outcomes.
Contents
Case 1. Patient with essential hypertension and left ventricular hypertrophy -- Case 2. Patient with essential hypertension and diastolic dysfunction -- Case 3. Patient with essential hypertension and microalbuminuria -- Case 4. Patient with essential hypertension and proteinuria -- Case 5. Patient with essential hypertension and atherosclerosis -- Case 6. Patient with essential hypertension and high pulse pressure.
Format
e-Book
Publication Type
Case Reports
Location
Online
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Imaging and Metabolism

https://libcat.nshealth.ca/en/permalink/provcat43247
Jason S. Lewis, Kayvan R. Keshari, editors. --Cham: Springer , c2018.
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Online
This book presents advanced molecular imaging techniques used to assess metabolic function. Covering state-of-the art modalities, it discusses the evaluation of a wide range of diseases that have a metabolic component, including cancer, inflammatory conditions, diabetes, neurodegeneration, and cardiovascular disorders. Imaging provides a quantitative perspective to the assessment of metabolic function and complements genetic analysis of disorders related to disrupted metabolism. Organized into …
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Other Authors
Lewis, Jason S.
Keshari, Kayvan R.
Responsibility
Jason S. Lewis, Kayvan R. Keshari, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2018
Physical Description
1 online resource (xiii, 331 p.) : 195 illus., 165 illus. in color
ISBN
9783319614014
9783319613994 (print ed.)
9783319614007 (print ed.)
9783319870731 (print ed.)
Subjects (MeSH)
Biomarkers - metabolism
Metabolic Diseases - diagnostic imaging
Metabolomics
Molecular Imaging - methods
Specialty
Diagnostic Imaging
Molecular Medicine
Abstract
This book presents advanced molecular imaging techniques used to assess metabolic function. Covering state-of-the art modalities, it discusses the evaluation of a wide range of diseases that have a metabolic component, including cancer, inflammatory conditions, diabetes, neurodegeneration, and cardiovascular disorders. Imaging provides a quantitative perspective to the assessment of metabolic function and complements genetic analysis of disorders related to disrupted metabolism. Organized into four parts, the book highlights basic principles in molecular imaging techniques; metabolic imaging approaches, including magnetic resonance imaging (MRI), single-photon emission computed tomography (SPECT), positron emission tomography (PET), and hybrid modalities; metabolic diseases; and future perspectives. Featuring contributions from leading authorities in radiology, oncology, cardiology, and neurology, Imaging and Metabolism is a pioneering exploration of the role of imaging modalities in assessing the physiological status of abnormal cells and diagnosing disease.
Contents
Part I. Basic Principles -- 1. Molecular Imaging and Molecular Imaging Technologies -- 2. A Topical Report on the Design Principles of Metabolism -- Part II. Metabolic Imaging Approaches -- 3. Overview of Positron-Emission Tomography Tracers for Metabolic Imaging -- 4. Introduction: MRI/MRS as Metabolic Imaging Tools -- 5. Metabolic Imaging Approaches: Optical Imaging -- Part III. Metabolic Diseases -- 6. Cancer Metabolism -- 7. Inflammation and Immune Metabolism -- 8. Imaging in Diabetes -- 9. Brain Disorders -- 10. Fatty Liver Disease -- 11. Imaging Myocardial Metabolism -- 12. Other Metabolic Syndromes.
Format
e-Book
Location
Online
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Imaging Biomarkers : Development and Clinical Integration

https://libcat.nshealth.ca/en/permalink/provcat41481
Luis Martí-Bonmatí, Angel Alberich-Bayarri, editors. --Cham: Springer , 2017.
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Online
This is the first book to cover all aspects of the development of imaging biomarkers and their integration into clinical practice, from the conceptual basis through to the technical aspects that need to be considered in order to ensure that medical imaging can serve as a powerful quantification instrument capable of providing valuable information on organ and tissue properties. The process of imaging biomarker development is considered step by step, covering proof of concept, proof of mechanism…
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Other Authors
Martí-Bonmatí, Luis
Alberich-Bayarri, Angel
Responsibility
Luis Martí-Bonmatí, Angel Alberich-Bayarri, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
2017
Physical Description
1 online resource (viii, 316 pages) : 104 illus., 75 illus. in color
ISBN
9783319435046
9783319435022 (print ed.)
Subjects (MeSH)
Biomarkers
Diagnostic Imaging - methods
Image Interpretation, Computer-Assisted
Abstract
This is the first book to cover all aspects of the development of imaging biomarkers and their integration into clinical practice, from the conceptual basis through to the technical aspects that need to be considered in order to ensure that medical imaging can serve as a powerful quantification instrument capable of providing valuable information on organ and tissue properties. The process of imaging biomarker development is considered step by step, covering proof of concept, proof of mechanism, image acquisition, image preparation, imaging biomarker analysis and measurement, detection of measurement biases (proof of principle), proof of efficacy and effectiveness, and reporting of results. Sources of uncertainty in the accuracy and precision of measurements and pearls and pitfalls in gold standards and biological correlation are discussed. In addition, practical use cases are included on imaging biomarker implementation in brain, oncologic, cardiovascular, musculoskeletal, and abdominal diseases. The authors are a multidisciplinary team of expert radiologists and engineers, and the book will be of value to all with an interest in the quantitative imaging of biomarkers in personalized medicine.
Contents
1. The Shift in Paradigm to Precision Medicine in Imaging: International Initiatives for the Promotion of Imaging Biomarkers -- 2. Introduction to the Stepwise Development of Imaging Biomarkers -- 3. Defining the Biological Basis and Clinical Question (Proof of Concept); Looking for the Interrelationship (Proof of Mechanism) -- 4. Image Acquisition: Modality and Protocol Definition -- 5. MRI Preprocessing -- 6. Imaging Biomarker Structural Analysis -- 7. Imaging Biomarker Model-Based Analysis -- 8. Imaging Biomarker Measurements -- 9. Detecting Measurement Biases: Sources of Uncertainty, Accuracy, and Precision of the Measurements -- 10. Validating the Imaging Biomarker: The Proof of Efficacy and Effectiveness -- 11. The Final Step: Imaging Biomarkers in Structured Reports -- 12. Pearls and Pitfalls in Gold Standards and Biological Correlation -- 13. Imaging Biobanks, Big Data, and Population-Based Imaging Biomarkers -- 14. A Proposed Imaging Biomarkers Analysis Platform Architecture for Integration in Clinics -- 15. Use Case I: Imaging Biomarkers in Neurological Disease. Focus on Multiple Sclerosis -- 16. Use Case II: Imaging Biomarkers and New Trends for Integrated Glioblastoma Management -- 17. Use Case III: Imaging Biomarkers in Breast Tumours. Development and Clinical Integration -- 18. Use Case IV: Imaging Biomarkers in Thorax and Heart -- 19. Use Case V: Imaging Biomarkers in Musculoskeletal Disorders -- 20. Use Case VI: Imaging Biomarkers in Diffuse Liver Disease. Quantification of Fat and Iron -- 21. Imaging Biomarkers in Clinical Trials.
Format
e-Book
Location
Online
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