Atlas of Thyroid and Neuroendocrine Tumor Markers
https://libcat.nshealth.ca/en/permalink/provcat43325
Luca Giovanella, editor.
--Cham:
Springer
, c2018.
- Available Online
- View e-Book
- Location
- Online
This book highlights the increase in thyroid tumors and NET and demonstrates the growing importance of circulating markers in diagnosis as well as treatment and follow-up. Dramatic technical improvements have heightened the clinical impact of well-established, conventional biochemical markers. In addition, more recent genetic and molecular approaches have provided innovative molecular markers. In this context, effective communication between clinicians and laboratory physicians/scientists is es…
- Available Online
- View e-Book
- Other Authors
- Giovanella, Luca
- Responsibility
- Luca Giovanella, editor
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2018
- Physical Description
- 1 online resource (xii, 249 p.) : 41 illus., 30 illus. in color
- ISBN
- 9783319625065
- 9783319625058 (print ed.)
- 9783319625072 (print ed.)
- 9783319873305 (print ed.)
- Subjects (MeSH)
- Biomarkers, Tumor
- Neuroendocrine Tumors - diagnosis
- Neuroendocrine Tumors - therapy
- Thyroid Neoplasms - diagnosis
- Thyroid Neoplasms - therapy
- Specialty
- Endocrinology
- Medical Oncology
- Abstract
- This book highlights the increase in thyroid tumors and NET and demonstrates the growing importance of circulating markers in diagnosis as well as treatment and follow-up. Dramatic technical improvements have heightened the clinical impact of well-established, conventional biochemical markers. In addition, more recent genetic and molecular approaches have provided innovative molecular markers. In this context, effective communication between clinicians and laboratory physicians/scientists is essential in allowing all those involved to fully profit from these exciting advances. In this comprehensive, up-to-date book, authors from different laboratory and clinical areas link laboratory and clinical topics. Analytical problems such as interferences, false-negative and false-positive results are discussed in depth, and flow-charts offer insights into identifying and avoiding them. Illustrated clinical cases detail the clinical role and limitations of different tumor markers. Lastly, it explores health technology assessment and economic issues. This is a valuable resource for endocrinologists, oncologists, nuclear medicine physicians, scientists and technologists who want to keep abreast of the latest developments.
- Contents
- Part I. Pathology and Pathobiology -- 1. Pathology and Immunohistochemistry in Thyroid Tumors -- 2. Pathology of Neuroendocrine Neoplasms: Morphological, Immunophenotypical, and Circulating Molecular Markers -- 3. Circulating Biomarkers: Biological Basis, Methods, and Interpretation Criteria -- Part II. Differentiated Thyroid Cancer -- 4. Differentiated Thyroid Cancer: Diagnosis, Therapy, and Follow-Up -- 5. Thyroglobulin and Thyroglobulin Antibodies -- 6. Circulating Molecular Biomarkers in Thyroid Cancer -- 7. Circulating Epithelial Tumor Cells in Thyroid Carcinoma -- Part III. Medullary Thyroid Carcinoma -- 8. Medullary Thyroid Carcinoma (MTC): Diagnosis, Treatment and Follow-Up -- 9. Calcitonin and Carcinoembryonic Antigen for the Diagnosis and Management of Medullary Thyroid Carcinoma -- 10. Procalcitonin: Are We Ready for Clinical Use? -- Part IV. Aggressive and Rare Thyroid Carcinoma -- 11. Aggressive Variants of Thyroid Carcinoma -- 12. Circulating Mucins and Cytokeratins in Aggressive Thyroid Cancers -- Part V. Thyroid Biomarkers on Fine-Needle Washouts -- 13. Measurement of Thyroid Tumor Markers on Fine-Needle Washouts -- Part VI. Neuroendocrine Tumors -- 14. Neuroendocrine Tumours: Diagnosis, Therapy and Follow-up -- 15. Circulating Markers in Neuroendocrine Tumors -- 16. Neuroendocrine Gene Transcripts: The Role of Molecular Biomarkers in Diagnosis and Management.
- Format
- e-Book
- Publication Type
- Atlas
- Location
- Online
Biomarkers in Neoplastic Neuropathology
https://libcat.nshealth.ca/en/permalink/provcat39834
Fausto Rodriguez, Cheng-Ying Ho.
--Cham:
Springer
, c2016.
- Available Online
- View e-Book
- Location
- Online
This book is a rich source of information on biomarkers applicable to the pathology of neoplastic disorders of the brain. Thorough descriptions are provided of the techniques currently available for clinical and experimental evaluation of biomarkers in brain neoplasms, including in situ hybridization, array-based methods, methylation profiling, next-generation sequencing, and practical gene panels. Incorporation of multiple biomarkers in the development of molecular subgroups with biologic and …
- Available Online
- View e-Book
- Author
- Rodriguez, Fausto
- Other Authors
- Ho, Cheng-Ying
- Responsibility
- Fausto Rodriguez, Cheng-Ying Ho
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2016
- Physical Description
- 1 online resource (x, 98 p. : 31 illus., 1 illus. in color)
- ISBN
- 9783319209319
- 9783319209302 (print ed.)
- Subjects (MeSH)
- Biomarkers, Tumor
- Nervous System Neoplasms - physiopathology
- Abstract
- This book is a rich source of information on biomarkers applicable to the pathology of neoplastic disorders of the brain. Thorough descriptions are provided of the techniques currently available for clinical and experimental evaluation of biomarkers in brain neoplasms, including in situ hybridization, array-based methods, methylation profiling, next-generation sequencing, and practical gene panels. Incorporation of multiple biomarkers in the development of molecular subgroups with biologic and therapeutic relevance is also discussed. A section on biobanking covers the equally important topic of optimal preservation of tissue and includes consideration of ethical considerations raised by the use of tissue obtained in clinical settings. The closing section discusses the major categories of neoplastic disorders involving the nervous system, with emphasis on diagnostic, prognostic, and predictive biomarkers used in the pathologic evaluation of different types of brain tumor.
- Contents
- Introduction -- Special Techniques -- Biobanking and Regulations -- Public Databases -- Biomarkers applied to specific tumor types.
- Format
- e-Book
- Location
- Online
Biomarkers of the Tumor Microenvironment : Basic Studies and Practical Applications
https://libcat.nshealth.ca/en/permalink/provcat41337
Lars A. Akslen, Randolph S. Watnick, editors.
--Cham:
Springer
, 2017.
- Available Online
- View e-Book
- Location
- Online
This book reviews different aspects of the cancer microenvironment, and its regulation and importance for tumor progression. Practical applications, in terms of how biomarkers are increasingly included in therapy protocols, will also be discussed. Biomarkers of the Tumour Microenvironment: Basic Studies and Practical Applications is aimed at research pathologists in the cancer field, and also cancer researchers from other backgrounds, especially those using morphology techniques and models focu…
- Available Online
- View e-Book
- Other Authors
- Akslen, Lars A
- Watnick, Randolph S
- Responsibility
- Lars A. Akslen, Randolph S. Watnick, editors
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- 2017
- Physical Description
- 1 online resource (xvii, 534 pages) : 52 illus., 51 illus. in color
- ISBN
- 9783319391472
- 9783319391458 (print ed.)
- Subjects (MeSH)
- Biomarkers, Tumor
- Tumor Microenvironment
- Abstract
- This book reviews different aspects of the cancer microenvironment, and its regulation and importance for tumor progression. Practical applications, in terms of how biomarkers are increasingly included in therapy protocols, will also be discussed. Biomarkers of the Tumour Microenvironment: Basic Studies and Practical Applications is aimed at research pathologists in the cancer field, and also cancer researchers from other backgrounds, especially those using morphology techniques and models focusing on cross-talk between different cell types in tumors.
- Contents
- Part I: Basic Mechanisms and Biomarkers -- 1. The Role of the Tumor Microenvironment in Regulating Angiogenesis -- 2. More Than a Barrier: How the Endothelium Instructs Metastasis -- 3. Tissue-Based Biomarkers of Tumor-Vascular Interactions -- 4. Role of the Extracellular Matrix in Tumor Stroma: Barrier or Support? -- 5. Stromal PDGF Receptors as Prognostic and Predictive Biomarkers -- 6. The Function and Diagnostic Potential of Adipocyte-Derived Factors in the Tumor Microenvironment -- 7. Inflammation and Cancer: The Role of Lipid Signaling in the Continuum Between Two Ends of the Tumor Spectrum -- 8. Cancer Immunity and Immune Evasion Mechanisms -- 9. Drivers of EMT and Immune Evasion -- 10. Inflammatory Biomarkers for Cancer -- 11. Immunology of Solid Tumors Beyond Tumor-Infiltrating Lymphocytes: The Role of Tertiary Lymphoid Structures -- 12. The Role of Platelets in the Tumor Microenvironment -- 13. Regulation of Tumor Progression and Metastasis by Bone Marrow-Derived Microenvironments -- 14. Neuropilin 1 and Neuropilin 2: Cancer Progression and Biomarker Analysis -- 15. The Role of Axl Receptor Tyrosine Kinase in Tumor Cell Plasticity and Therapy Resistance -- Part II: Organ Related Biomarker Studies -- 16. Gene Expression Signatures of the Tumor Microenvironment: Relation to Tumor Progress in Breast Cancer -- 17. MR-Derived Biomarkers for Cancer Characterization -- 18. The Influence of Tissue Architecture on Drug Response: Anticancer Drug Development in High-Dimensional Combinatorial Microenvironment Platforms -- 19. Models of Tumor Progression in Prostate Cancer -- 20. Tumor-Host Interactions in Malignant Gliomas -- 21. The Tumor Microenvironment in Cutaneous Melanoma: Friend or Foe -- 22. Biomarker Panels and Contemporary Practice in Clinical Trials of Targeted Therapy.
- Format
- e-Book
- Location
- Online
Cancer Proteomics : From Bench to Bedside
https://libcat.nshealth.ca/en/permalink/provcat40631
edited by Sayed S. Daoud.
--Totowa, NJ:
Humana Press
, c2008.
- Available Online
- View e-Book
- Location
- Online
Over the past 20 years or so, there have been tremendous advances in our understanding of how normal cells transform to cancer and the importance of signaling pathways in cancer initiation and progression. Therefore, proteomics technologies must be improved for more global analysis of protein content of cells, tissues and body fluids as well as the posttranslational modifications to allow for proper detections and validation. In Cancer Proteomics, the authors collectively provide the current st…
- Available Online
- View e-Book
- Other Authors
- Daoud, Sayed S
- Responsibility
- edited by Sayed S. Daoud
- Place of Publication
- Totowa, NJ
- Publisher
- Humana Press
- Date of Publication
- c2008
- Physical Description
- 1 online resource (xii, 264 p. : 5 illus. in color)
- Series Title
- Cancer drug discovery and development
- ISBN
- 9781597451697
- 9781588298584 (print ed.)
- Subjects (MeSH)
- Antineoplastic Agents
- Biomarkers, Tumor
- Neoplasms
- Proteomics - methods
- Abstract
- Over the past 20 years or so, there have been tremendous advances in our understanding of how normal cells transform to cancer and the importance of signaling pathways in cancer initiation and progression. Therefore, proteomics technologies must be improved for more global analysis of protein content of cells, tissues and body fluids as well as the posttranslational modifications to allow for proper detections and validation. In Cancer Proteomics, the authors collectively provide the current status of proteomics in cancer therapy and offers the existing technologies used in proteomics that allow for protein profiling and for the identification of druggable targets in human samples. Mass spectrometry based protein characterization and protein microarrays hold great promise of predicting response to specific drugs in cancer therapy. Insightful to the reader with broad perspectives on topics related to the use of proteomic strategies in cancer therapy, Cancer Proteomics offers anticipated challenges that may arise from its application in daily practice.
- Contents
- Part I. Proteomics Technologies -- Current and Emerging Mass Spectrometry Instrumentation and Methods for Proteomic Analyses -- Part II. Cell Signaling Proteomics -- Integration of Genomics and Proteomics in Dissecting p53 Signaling -- Proteomic Profiling of Tyrosine Kinases as Pharmacological Endpoints for Targeted Cancer Therapy -- Part III. Tumor Proteomics -- Oncoproteomics for Personalized Management of Cancer -- Application of Serum and Tissue Proteomics to Understand and Detect Solid Tumors -- Insight on Renal Cell Carcinoma Proteome -- Proteomics in Lung Cancer -- Proteomic Strategies of Therapeutic Individualization and Target Discovery in Acute Myeloid Leukemia -- New Tumor Biomarkers: Practical Considerations Prior to Clinical Application -- Part IV. Bioinformatics and Regulatory Aspects of Proteomics -- Annotating the Human Proteome: From Establishing a Parts List to a Tool for Target Identification -- Regulatory Issues in the Co-Development of Oncology Drugs and Proteomic Tests: An Overview.
- Format
- e-Book
- Location
- Online
Genomic Medicine : A Practical Guide
https://libcat.nshealth.ca/en/permalink/provcat44958
Laura J. Tafe, Maria E. Arcila, editors.
--Cham:
Springer
, c2020.
- Available Online
- View e-Book
- Location
- Online
The field of Molecular Diagnostics is rapidly evolving and molecular characterization of neoplasms is becoming an increasingly important part of the pathologic work up and diagnosis of many tumor types. This work provides a high-yield reference book that compiles critical information related to molecular biomarkers for various solid tumor and hematologic malignancy subtypes. It is succinct yet comprehensive enough to be suitable for fellows in training and medical professionals with an interest…
- Available Online
- View e-Book
- Other Authors
- Tafe, Laura J.
- Arcila, Maria E.
- Responsibility
- Laura J. Tafe, Maria E. Arcila, editors
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2020
- Physical Description
- 1 online resource (x, 325 p.) : 21 illus., 20 illus. in color
- ISBN
- 9783030229221
- 9783030229214 (Print ed.)
- 9783030229238 (Print ed.)
- Subjects (MeSH)
- Biomarkers, Tumor
- Molecular Diagnostic Techniques
- Pathology, Molecular
- Precision Medicine - methods
- Specialty
- Genetics, Medical
- Abstract
- The field of Molecular Diagnostics is rapidly evolving and molecular characterization of neoplasms is becoming an increasingly important part of the pathologic work up and diagnosis of many tumor types. This work provides a high-yield reference book that compiles critical information related to molecular biomarkers for various solid tumor and hematologic malignancy subtypes. It is succinct yet comprehensive enough to be suitable for fellows in training and medical professionals with an interest in molecular pathology and biomarkers. The book covers many aspects of molecular diagnostics, from techniques to applications and comprehensive summaries of the current molecular biomarkers of critical importance in solid and liquid tumors. Attention is also specifi cally devoted to bioinformatics and next generation sequencing, as well as pre-analytical issues that must be considered for accurate interpretation of molecular results in the context of overall patient care. This text focuses on clinical utility and validity and serves as an “owner’s manual” in Genomic Diagnostics for the practicing pathologist, pathology fellows and residents and other health care providers. Physicians will find this book invaluable as a quick reference for current molecular testing modalities and guidelines, tumor board preparation, deciding which test to order and interpreting genomic laboratory results. In addition, it is an accessible for trainees as a board review preparation reference.
- Contents
- Part I. General Concepts -- Pre-Analytics, Current Testing Technologies, and Limitations of Testing -- Next Generation Sequencing -- Cell-Free DNA Testing -- Role of Bioinformatics in Molecular Medicine -- Interpreting Genomic Reports -- Part II. Applications in Solid Tumors -- Lung Carcinoma -- GI including GIST -- Breast -- Genitourinary Tumors -- Gynecologic Malignancies -- Sarcomas -- Salivary Gland Carcinomas -- Sinonasal Carcinomas -- Part III. Applications in Hematopathology -- Acute Myeloid Neoplasms -- Chronic Myeloid Neoplasms -- Lymphomas.
- Format
- e-Book
- Location
- Online
Molecular diagnostics and treatment of pancreatic cancer
https://libcat.nshealth.ca/en/permalink/provcat50939
Azmi, Asfar.
(1st ed.)
--Philadelphia, PA:
Elsevier
, 2014.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Author
- Azmi, Asfar
- Edition
- 1st ed.
- Place of Publication
- Philadelphia, PA
- Publisher
- Elsevier
- Date of Publication
- 2014
- ISBN
- 9780124081031
- Subjects (MeSH)
- Biomarkers, Tumor
- Pancreatic Neoplasms - diagnosis
- Molecular Diagnostic Techniques
- Pancreatic Neoplasms - genetics
- Pancreatic Neoplasms - therapy
- Signal Transduction
- Notes
- Access to this online resource is restricted to IWK Health Centre employees working from inside the hospital network.
- Format
- e-Book
- Location
- Online
Molecular Diagnostics in Cancer Patients
https://libcat.nshealth.ca/en/permalink/provcat44270
Kamla Kant Shukla, Praveen Sharma, Sanjeev Misra, editors.
--Singapore:
Springer
, 2019.
- Available Online
- View e-Book
- Location
- Online
This book aims to bring together a broad variety of examples of the role of pharmacogenomics in current drug development, uncovering dynamic concentration-dependent drug responses on biological systems to understand pharmacodynamics responses in human cancer where genetic lesions serve as tumor markers and provide a basis for cancer diagnosis. The book describes methods and protocols applied in molecular diagnostics. It offers pathologists and researchers providing molecular diagnostic services…
- Available Online
- View e-Book
- Other Authors
- Shukla, Kamla Kant
- Sharma, Praveen
- Misra, Sanjeev
- Responsibility
- Kamla Kant Shukla, Praveen Sharma, Sanjeev Misra, editors
- Place of Publication
- Singapore
- Publisher
- Springer
- Date of Publication
- 2019
- Physical Description
- 1 online resource (viii, 341 p.) : 45 illus., 43 illus. in color
- ISBN
- 9789811358777
- 9789811358760 (Print ed.)
- 9789811358784 (Print ed.)
- Subjects (MeSH)
- Biomarkers, Tumor
- Molecular Diagnostic Techniques
- Neoplasms - diagnosis
- Pharmacogenetics
- Specialty
- Medical Oncology
- Molecular Medicine
- Abstract
- This book aims to bring together a broad variety of examples of the role of pharmacogenomics in current drug development, uncovering dynamic concentration-dependent drug responses on biological systems to understand pharmacodynamics responses in human cancer where genetic lesions serve as tumor markers and provide a basis for cancer diagnosis. The book describes methods and protocols applied in molecular diagnostics. It offers pathologists and researchers providing molecular diagnostic services an array of the most recent and readily accessible reference to compare methods and techniques. Highlights include the molecular diagnosis of genetic aberrations by quantitative polymerase reaction (qPCR), sequence-specific oligonucleotide arrays, next-generation sequencing (NGS), CGH arrays-and methodologies directed at the detection of epigenetic events, high-throughput nucleic acid and protein arrays, direct sequencing and FISH-based methodologies, currently used in the diagnosis of solid tumors. The book also includes an innovative line of treatment in relation to the molecular prognosis, diagnosis and pharmacogenomics in the actual practice of clinical findings at molecular levels. The book covers the applications of numerous genetic testing methodologies; in approximately the chronological order of discovery and high-throughput diagnosis using advanced genomic approaches to identify such genes, in the search for novel drug targets and/or key determinants of drug reactions. It also promotes a wider understanding of molecular diagnostics among physicians, medical students, and scientists in academics, industry and corporate world.
- Contents
- 1. Recent Advances in Molecular Diagnostic Approaches for Cancer -- 2. Molecular Diagnosis of Gall Bladder Cancer -- 3. Molecular Diagnostics for Lung Cancer -- 4. Predicting E3 Ubiquitin Ligases as Possible Promising Biomarkers for Brain Tumors -- 5. Molecular Diagnostics in Melanoma: An Update -- 6. Molecular Diagnostics in Breast Cancer -- 7. Molecular Diagnostics in Non-Hodgkin Lymphoma -- 8. Molecular Diagnosis of Cervical Cancer -- 9. Molecular Diagnostics in Colorectal Cancer -- 10. Molecular Diagnostics in Pancreatic Cancer -- 11. Molecular Diagnostics in Head and Neck Squamous Cell Carcinoma -- 12. Molecular Diagnostic in Prostate Cancer -- 13. Molecular Diagnostics in Renal Cancer -- 14. Molecular Biomarkers and Urinary Bladder Cancer (UBC) -- 15. Molecular Pathway and Fluorescence In Situ Hybridization Testing of ERBB2 (HER2) Gene Amplification in Invasive Ductal Carcinoma of Breast -- 16. Exploring Potential of RPPA Technique in Oral Cancer Biomarker Discovery Research -- 17. Molecular Diagnostics in Liver Cancer -- 18. Molecular Diagnosis of Uterine Cancer -- 19. Molecular Diagnosis in Ovarian Carcinoma.
- Format
- e-Book
- Location
- Online
Molecular Pathology of Nervous System Tumors : Biological Stratification and Targeted Therapies
https://libcat.nshealth.ca/en/permalink/provcat38980
Matthias A. Karajannis, David Zagzag, editors.
--New York, NY:
Springer
, c2015.
- Available Online
- View e-Book
- Location
- Online
This book serves as a comprehensive guide to the rapidly evolving field of molecular neuropathology of nervous system tumors, as well as the underlying biology and emerging molecular targeted therapies. Special emphasis is given to already established and emerging molecular diagnostic tests in neuropathology, as well as molecular targeted therapies. The book is organized by clinico-pathologic disease entities, and each chapter is written by a team of experts in their field. Molecular Pathology …
- Available Online
- View e-Book
- Other Authors
- Karajannis, Matthias A
- Zagzag, David
- Responsibility
- Matthias A. Karajannis, David Zagzag, editors
- Place of Publication
- New York, NY
- Publisher
- Springer
- Date of Publication
- c2015
- Physical Description
- 1 online resource (xv, 247 p. : 121 illus., 78 illus. in color)
- Series Title
- Molecular pathology library
- ISBN
- 9781493918300
- 9781493918294 (print ed.)
- ISSN
- 1935-987X
- Subjects (MeSH)
- Biomarkers, Tumor
- Central Nervous System Neoplasms - genetics
- Central Nervous System Neoplasms - pathology
- Central Nervous System Neoplasms - therapy
- Molecular Diagnostic Techniques
- Molecular Targeted Therapy
- Abstract
- This book serves as a comprehensive guide to the rapidly evolving field of molecular neuropathology of nervous system tumors, as well as the underlying biology and emerging molecular targeted therapies. Special emphasis is given to already established and emerging molecular diagnostic tests in neuropathology, as well as molecular targeted therapies. The book is organized by clinico-pathologic disease entities, and each chapter is written by a team of experts in their field. Molecular Pathology of Nervous System Tumors is of great value and utility for physicians and scientists involved with or interested in the up-to-date diagnosis and treatment of patients with brain tumors.
- Contents
- [publisher supplied] 1. Hereditary Predisposition to Primary CNS Tumors -- 2. Brain Tumor Stem Cells -- 3. Molecular Pathology Techniques -- 4. Low-grade Gliomas -- 5. Ependymoma -- 6. Adult High-Grade (Diffuse) Glioma -- 7. High-Grade Gliomas and DIPG (Pediatric) -- 8.Oligodendroglial Tumors: Current Treatments and the Promise of Molecular Genetics -- 9.Molecular Pathology of Nervous System Tumors: Medulloblastoma and CNS Primitive Neuroectodermal Tumors -- 10. Subependymal Giant Cell Astrocytoma -- 11. Germ Cell Tumors -- 12. Choroid Plexus Tumors. -- 13. Atypical Teratoid Rhabdoid Tumors -- 14. Hemangioblastoma -- 15. Schwannomas -- 16. Molecular Pathology of Nervous System Tumors -- 17. Molecular Genetic Pathology of Meningiomas.
- Format
- e-Book
- Location
- Online
Targeted Therapies for Solid Tumors : A Handbook for Moving Toward New Frontiers in Cancer Treatment
https://libcat.nshealth.ca/en/permalink/provcat39001
Antonio Russo, Rafael Rosell, Christian Rolfo, editors.
--New York, NY:
Springer New York : Imprint: Humana Press
, c2015.
- Available Online
- View e-Book
- Location
- Online
This volume provides readers a comprehensive and state-of-the-art overview about the range of applications of targeted therapies for solid tumors. The sections of the book have been structured to review the oncogene addicted tumors, the pharmacology and clinical development of new molecularly targeted agents, the use of biomarkers as prognostic, predictive and surrogate endpoints, and the evaluation of tumor response and specific malignancies treated with targeted agents. The book also covers s…
- Available Online
- View e-Book
- Other Authors
- Russo, Antonio
- Rosell, Rafael
- Rolfo, Christian
- Responsibility
- Antonio Russo, Rafael Rosell, Christian Rolfo, editors
- Place of Publication
- New York, NY
- Publisher
- Springer New York : Imprint: Humana Press
- Date of Publication
- c2015
- Physical Description
- 1 online resource (x, 269 p. : 29 illus., 23 illus. in color)
- Series Title
- Current clinical pathology
- ISBN
- 9781493920471
- 9781493920464 (print ed.)
- ISSN
- 2197-781X
- Subjects (MeSH)
- Antineoplastic Agents
- Biomarkers, Tumor
- Molecular Targeted Therapy
- Neoplasms - drug therapy
- Proto-Oncogene Proteins
- Abstract
- This volume provides readers a comprehensive and state-of-the-art overview about the range of applications of targeted therapies for solid tumors. The sections of the book have been structured to review the oncogene addicted tumors, the pharmacology and clinical development of new molecularly targeted agents, the use of biomarkers as prognostic, predictive and surrogate endpoints, and the evaluation of tumor response and specific malignancies treated with targeted agents. The book also covers some of the newest developments in cancer therapy that are not adequately covered by any current available literature. Written by recognized experts in the field, Targeted Therapies for Solid Tumors: A Handbook for Moving Toward New Frontiers in Cancer Treatment provides a unique and valuable resource in the field of molecular oncology, both for those currently in training, and for those already in clinical or research practice.
- Contents
- Introduction -- Oncogene Addiction in Solid Tumors -- Pharmacology and Clinical Development of New Molecularly Targeted Agents -- Biomarkers as Prognostic, Predictive and Surrogate Endpoints -- Evaluation of Response in Malignant Tumors Treated with Targeted Agents -- Targeted Therapies for HER2-Positive Breast Cancer -- Role of PARP Inhibitors in Triple Negative Breast Cancer (TNBC) -- Targeted Therapies in Squamous Cell Carcinoma of the Head and Neck -- Targeted Therapies for NSCLC -- Targeted Therapies for Gastric Cancer -- Targeted Therapies for Pancreatic Cancer -- Targeted Therapies in Hepatocellular Carcinoma -- Targeted Therapies for Colorectal Cancer -- Targeted Therapy in Gastrointestinal Stromal Tumors -- Targeted Therapies in Kidney Cancer -- Targeted Therapies in Melanoma -- Targeted Therapies for Prostate Cancer -- Targeted Therapies for Bone Metastases.
- Format
- e-Book
- Location
- Online
Translational Pancreatic Cancer Research : From Understanding of Mechanisms to Novel Clinical Trials
https://libcat.nshealth.ca/en/permalink/provcat45203
Christoph W. Michalski, Jonas Rosendahl, Patrick Michl, Jörg Kleeff, editors.
--Cham:
Humana Press
, c2020.
- Available Online
- View e-Book
- Location
- Online
This book incorporates a multi-disciplinary approach to present how research results can be translated into clinical trials. The first part begins with a chapter on variants of pancreatic cancer, precursor lesions and groups of people at risk to developing the disease. There is a particular focus on intraductal papillary mucinous neoplasia as a large-scale clinical challenge in pancreatology. The next two parts focus on diagnosis, biomarkers and stratification that emphasize how various approac…
- Available Online
- View e-Book
- Other Authors
- Michalski, Christoph W.
- Rosendahl, Jonas
- Michl, Patrick
- Kleeff, Jörg
- Responsibility
- Christoph W. Michalski, Jonas Rosendahl, Patrick Michl, Jörg Kleeff, editors
- Place of Publication
- Cham
- Publisher
- Humana Press
- Date of Publication
- c2020
- Physical Description
- 1 online resource (xii, 245 p.) : 18 illus., 17 illus. in color
- Series Title
- Molecular and translational medicine
- ISBN
- 9783030494766
- 9783030494759 (Print ed.)
- 9783030494773 (Print ed.)
- 9783030494780 (Print ed.)
- ISSN
- 2197-7852
- Specialty
- Medical Oncology
- Pathology
- Abstract
- This book incorporates a multi-disciplinary approach to present how research results can be translated into clinical trials. The first part begins with a chapter on variants of pancreatic cancer, precursor lesions and groups of people at risk to developing the disease. There is a particular focus on intraductal papillary mucinous neoplasia as a large-scale clinical challenge in pancreatology. The next two parts focus on diagnosis, biomarkers and stratification that emphasize how various approaches to biomarker development are important as both prognostic and predictive tools. The final part consists of personalized treatment approaches that include preclinical models of pancreatic cancer and stromal, epigenetic and metabolism targeting as promising approaches to be translated into early phase clinical trials. Chapters within this part also deal with approaches that are close to being implemented in clinical practice or are already being tested in (early) clinical trials, such as those that targeting the immune systems and strategies to overcome immunotherapy resistance; phase 1 clinical trials and translational approaches in surgical treatment. Written by experts in their fields, Translational Pancreatic Cancer Research provides an outlook towards future directions by integrating information both from basic and clinical research and though demonstrating pathways to better understanding pancreatic cancer and current approaches to translating these into clinical practice.
- Contents
- Part I. PDAC Variants and Risk of Disease -- Subtypes of Pancreatic Adenocarcinoma -- Part II. PDAC Precursors and Early Diagnosis -- Surveillance and Intervention in IPMN -- Novel Biomarkers of Invasive IPMN -- Part III. Diagnosis, Biomarkers and Stratification -- Challenges and Opportunities for Early Pancreatic Cancer Detection: Role for protein biomarkers -- Metabolic Biomarkers of Pancreatic Cancer -- Blood-Based Circulating RNAs as Preventive, Diagnostic, Prognostic and Drugable Biomarkers for Pancreatic Ductal Adenocarcinoma -- Circulating tumor DNA as a novel biomarker for pancreatic cancer -- PDAC Subtypes/Stratification -- Circulating Tumor Cells as Biomarkers in Pancreatic Cancer -- Part IV. Personalized Treatment Approaches -- Personalized Models of Human PDAC -- Therapeutic Targeting of Stromal Components -- Epigenetic Targeting -- Targeting Metabolism -- Targeting the Immune System in Pancreatic Cancer -- Phase I Trials in Pancreatic Cancer -- Translational Approaches in Surgical Treatment.
- Format
- e-Book
- Location
- Online
Tumor Deposits : Mechanism, Morphology and Prognostic Implications
https://libcat.nshealth.ca/en/permalink/provcat43249
Sulen Sarioglu.
--Cham:
Springer
, c2018.
- Available Online
- View e-Book
- Location
- Online
This book presents the morphology, possible mechanisms of formation, and clinical relevance of tumor deposits (TDs) in different organs and parts of the body. It also describes the diagnostic features that are currently available for TDs and discusses the prognostic impact of TDs. The poor prognostic and predictive values of TDs were found to be as strong as distant metastasis in different series. TDs, best characterized by colorectal cancer, are irregular discrete tumor masses that are discont…
- Available Online
- View e-Book
- Author
- Sarioglu, Sulen
- Responsibility
- Sulen Sarioglu
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2018
- Physical Description
- 1 online resource (xiv, 189 p.) : 136 illus. in color
- ISBN
- 9783319685823
- 9783319685816 (print ed.)
- 9783319685830 (print ed.)
- 9783319886244 (print ed.)
- Subjects (MeSH)
- Biomarkers, Tumor
- Neoplasm Staging
- Neoplasms - pathology
- Specialty
- Medical Oncology
- Pathology
- Abstract
- This book presents the morphology, possible mechanisms of formation, and clinical relevance of tumor deposits (TDs) in different organs and parts of the body. It also describes the diagnostic features that are currently available for TDs and discusses the prognostic impact of TDs. The poor prognostic and predictive values of TDs were found to be as strong as distant metastasis in different series. TDs, best characterized by colorectal cancer, are irregular discrete tumor masses that are discontinuous from the leading edge of the tumor. However, even in colorectal cancers, the place of TDs in tumor staging (tumor, lymph node and distant metastasis categories) remains controversial. This book presents the possible mechanisms of TD formation, including neurotrophic and angiotrophic extravascular migratory metastasis, in comparison with the well-known mechanisms of metastasis. It also shows that TDs were identified in esophageal, gastric, salivary gland, head and neck, and breast carcinomas. The possible mechanisms leading to the frequent association of TDs and peritoneal carcinomatosis are discussed. This is a valuable resource for pathologists, oncologists, and surgeons who are looking for detailed information on the latest scientific insights into the pathology and prognostic implications of TDs.
- Contents
- 1. Mechanisms of Metastasis -- 2. Tumor Deposits: Mechanisms, Morphology, and Differential Diagnosis -- 3. Tumor Deposits in Colorectal Cancer -- 4. Tumor Deposits in Gastric Cancer -- 5. Tumor Deposits in Esophageal Carcinomas -- 6. Peritoneal Carcinomatosis: Relation to Tumor Deposits -- 7. Tumor Deposits in Salivary Gland Carcinomas -- 8. Tumor Deposits in Head and Neck Tumors -- 9. Tumor Deposits in Breast Carcinomas.
- Format
- e-Book
- Location
- Online
