Brain Cancer
https://libcat.nshealth.ca/en/permalink/provcat29753
edited by M. A. Hayat.
--[Dordrecht]:
Springer
, c2010.
- Available Online
- View e-Book
- Location
- Online
This eighth volume in the series Methods of Cancer Diagnosis, Therapy, and Prognosis discusses in detail the classification of the CNS tumors as well as brain tumor imaging. Scientists and Clinicians have contributed state of the art chapters on their respective areas of expertise, providing the reader a whole field view of the CNS tumors and brain tumor imaging in Europe. This fully illustrated volume: Explains the genetics of malignant brain tumors and gene amplification using quantitative-PC…
- Available Online
- View e-Book
- Author
- Hayat, M. A
- Responsibility
- edited by M. A. Hayat
- Alternate Title
- Methods of cancer diagnosis, therapy, and prognosis
- Place of Publication
- [Dordrecht]
- Publisher
- Springer
- Date of Publication
- c2010
- Physical Description
- 1 online resource (xlvi, 392 p. : ill.)
- Series Vol.
- v. 8
- Series Title
- Methods of cancer diagnosis, therapy, and prognosis
- ISBN
- 9789048186655
- 9789048186648 (print ed.)
- Subjects (MeSH)
- Brain neoplasms - diagnosis
- Brain neoplasms - therapy
- Prognosis
- Subjects (LCSH)
- Oncology
- Abstract
- This eighth volume in the series Methods of Cancer Diagnosis, Therapy, and Prognosis discusses in detail the classification of the CNS tumors as well as brain tumor imaging. Scientists and Clinicians have contributed state of the art chapters on their respective areas of expertise, providing the reader a whole field view of the CNS tumors and brain tumor imaging in Europe. This fully illustrated volume: Explains the genetics of malignant brain tumors and gene amplification using quantitative-PCR; Presents a large number of standard and new imaging modalities, including magnetic resonance imaging, functional magnetic resonance imaging, diffusion tensor imaging, amide proton transfer imaging, positron emission tomography, single photon emission computed tomography, magnetic resonance single voxel spectroscopy and intraoperative ultrasound imaging, for staging and diagnosing various primary and secondary brain cancers; Explains the usefulness of imaging methods for planning and monitoring (assessment) therapy for cancers; Discusses diagnosis and treatment of primary CNS lymphomas, CNS atypical teratoid/rhabdoid and CNS Rosai-Dorfman disease; Includes the subject of translational medicine. Professor Hayat has summarized the problems associated with the complexities of research publications and has been successful in editing a must-read volume for oncologists, cancer researchers, medical teachers and students of cancer biology.
- Contents
- 1. The World Health Organization Classification of the Central Nervous System Tumors: An Update Using Imaging -- 2. Brain Tumor Imaging: European Association of Nuclear Medicine Procedure Guidelines -- 3. Assessment of Heterogeneity in Malignant Brain Tumors -- 4. Diagnosing and Grading of Brain Tumors: Immunohistochemistry -- 5. Malignant Brain Tumors: Roles of Aquaporins -- 6. Brain Metastases: Gene Amplification Using Quantitative Real-Time Polymerase Chain Reaction Analysis -- 7. Cyclic AMP Phosphodiesterase-4 in Brain Tumor Biology: Immunochemical Analysis -- 8. Radiosurgical Treatment of Progressive Malignant Brain Tumors -- 9. Anti-vascular Therapy for Brain Tumors -- 10. Glial Brain Tumors: Antiangiogenic Therapy -- 11. Brain Tumors: Amide Proton Transfer Imaging -- 12. Diffusion Tensor Imaging in Rat Models of Invasive Brain Tumors -- 13. Brain Tumors: Diffusion Imaging and Diffusion Tensor Imaging -- 14. Brain Tumors: Planning and Monitoring Therapy with Positron Emission Tomography -- 15. Clinical Evaluation of Primary Brain Tumor: O-(2-[18F]Fluorethyl)-L-Tyrosine Positron Emission Tomography -- 16. Combined Use of [F-18]Fluorodeoxyglucose and [C-11]Methionine in 45 PET-Guided Stereotactic Brain Biopsies -- 17. Hemorrhagic Brain Neoplasm – 99mTc-Methoxyisobutyl Isonitrile-Single Photon Emission Computed Tomography -- 18. Brain Tumor Imaging Using p-[123I]Iodo-L-Phenylalanine and SPECT -- 19. Diagnosis and Staging of Brain Tumours: Magnetic Resonance Single Voxel Spectra -- 20. Parallel Magnetic Resonance Imaging Acquisition and Reconstruction: Application to Functional and Spectroscopic Imaging in Human Brain -- 21. Intra-axial Brain Tumors: Diagnostic Magnetic Resonance Imaging - 22. Brain Tumors: Apparent Diffusion Coefficient at Magnetic Resonance Imaging -- 23. Magnetic Resonance Imaging of Brain Tumors Using Iron Oxide Nanoparticles -- 24. Metastatic Solitary Malignant Brain Tumor: Magnetic Resonance Imaging -- 25. Brain Tumor Resection: Intra-operative Ultrasound Imaging -- 26. Primary Central Nervous System Lymphomas: Salvage Treatment -- 27. Central Nervous System Atypical Teratoid/Rhabdoid Tumors: Role of Insulin-Like Growth Factor I Receptor -- 28. Central Nervous System Rosai–Dorfman Disease
- Format
- e-Book
- Location
- Online
Brain Tumor Imaging
https://libcat.nshealth.ca/en/permalink/provcat40337
Elke Hattingen, Ulrich Pilatus, editors.
(1st ed.)
--Berlin, Heidelberg:
Springer
, c2016.
- Available Online
- View e-Book
- Location
- Online
This book describes the basics, the challenges and the limitations of state of the art brain tumor imaging and examines in detail its impact on diagnosis and treatment monitoring. It is intended for radiologists, neurologists, neurosurgeons, oncologists and other scientists in the biomedical field with an interest in neuro-oncology. The book opens with an introduction to the clinically relevant physical principles of brain imaging. Since MR methodology plays a crucial role in brain imaging, the…
- Available Online
- View e-Book
- Other Authors
- Hattingen, Elke
- Pilatus, Ulrich
- Responsibility
- Elke Hattingen, Ulrich Pilatus, editors
- Edition
- 1st ed.
- Place of Publication
- Berlin, Heidelberg
- Publisher
- Springer
- Date of Publication
- c2016
- Physical Description
- 1 online resource (vii, 161 p. : 110 illus., 43 illus. in color)
- Series
- Medical radiology. Diagnostic imaging
- Series Title
- Medical radiology (Series)
- ISBN
- 9783642450402
- 9783642450396 (print ed.)
- ISSN
- 0942-5373
- Subjects (MeSH)
- Brain neoplasms - diagnosis
- Neuroimaging
- Abstract
- This book describes the basics, the challenges and the limitations of state of the art brain tumor imaging and examines in detail its impact on diagnosis and treatment monitoring. It is intended for radiologists, neurologists, neurosurgeons, oncologists and other scientists in the biomedical field with an interest in neuro-oncology. The book opens with an introduction to the clinically relevant physical principles of brain imaging. Since MR methodology plays a crucial role in brain imaging, the fundamental aspects of MR spectroscopy, MR perfusion and diffusion-weighted MR methods are described, focusing on the specific demands of brain tumor imaging. The potential and limits of conventional MR imaging and new imaging methodology are carefully addressed. In the main part of the book, the most important imaging criteria for the differential diagnosis of solid and necrotic brain tumors are delineated and illustrated in examples. Specific issues relevant to all MR modalities used for this purpose are thoroughly discussed. A closing section is devoted to the use of MR methods for the monitoring of brain tumor therapy.
- Contents
- Introduction -- Part I: Technologies & Methods -- DWI, PWI, MR Spectroscopy -- Part II: Limits of conventional MR imaging -- Part III: Differential diagnosis of solid intracerebral brain tumors -- Part IV: Differential diagnosis of necrotic brain tumors -- Part V: Monitoring brain tumor therapy -- Subject Index.
- Format
- e-Book
- Location
- Online
Imaging of Brain Tumors with Histological Correlations
https://libcat.nshealth.ca/en/permalink/provcat28571
edited by Antonios Drevelegas.
(2nd ed.)
--Berlin, Heidelberg:
Springer-Verlag
, c2011.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Author
- Drevelegas, Antonios
- Responsibility
- edited by Antonios Drevelegas
- Edition
- 2nd ed.
- Place of Publication
- Berlin, Heidelberg
- Publisher
- Springer-Verlag
- Date of Publication
- c2011
- ISBN
- 9783540876502
- Subjects (MeSH)
- Brain neoplasms - diagnosis
- Brain neoplasms - pathology
- Diagnostic Imaging
- Subjects (LCSH)
- Oncology
- Diagnostic Imaging
- Format
- e-Book
- Location
- Online
Stereotactic biopsy
https://libcat.nshealth.ca/en/permalink/chpams34172
Nova Scotia Health Authority. QEII. Division of Neurosurgery.
Halifax, NS:
Nova Scotia Health Authority
, 2017.
- Pamphlet Number
- 0059
- Available Online
- View Pamphlet
Sterotactic surgery is used to diagnose or treat several types of brain-related conditions, such as movement disorders, pain syndromes, and brain tumours/tumors. A biopsy is when a small sample of tissue is taken. A pathologist (a doctor who diagnoses changes in body tissues or fluids) will look at the tissue sample and make a diagnosis. What to expect before, during, and after surgery are stated.
- Available Online
- View Pamphlet
- Corporate Author
- Nova Scotia Health Authority. QEII. Division of Neurosurgery
- Place of Publication
- Halifax, NS
- Publisher
- Nova Scotia Health Authority
- Date of Publication
- 2017
- Format
- Pamphlet
- Language
- English
- Physical Description
- 1 electronic document ([4] p.) : digital, PDF file
- Subjects (MeSH)
- Stereotaxic Techniques
- Neurosurgery - methods
- Brain Neoplasms - diagnosis
- Subjects (LCSH)
- Stereotaxic techniques
- Brain--Surgery
- Brain--Tumors--Diagnosis
- Abstract
- Sterotactic surgery is used to diagnose or treat several types of brain-related conditions, such as movement disorders, pain syndromes, and brain tumours/tumors. A biopsy is when a small sample of tissue is taken. A pathologist (a doctor who diagnoses changes in body tissues or fluids) will look at the tissue sample and make a diagnosis. What to expect before, during, and after surgery are stated.
- Responsibility
- Prepared by: Division of Neurosurgery
- Pamphlet Number
- 0059
Tumors of the Central Nervous System. Vol. 1, Gliomas, Glioblastoma (Part 1)
https://libcat.nshealth.ca/en/permalink/provcat40903
edited by M. A. Hayat.
--Dordrecht:
Springer
, c2011.
- Available Online
- View e-Book
- Location
- Online
The most recent developments in diagnostic and therapeutic aspects of Gliomas (Glioblastoma) in the brain are presented. The importance of personalized medicine and clinical validation for targeted therapy are discussed. The identification of various types of biomarkers is included. The identification and validation of brain cancer (glioblastoma) genes are discussed. Role of cancer stem cells in the initiation, progression, and persistence of malignant gliomas is explained. The use of surgical …
- Available Online
- View e-Book
- Other Authors
- Hayat, M. A
- Responsibility
- edited by M. A. Hayat
- Place of Publication
- Dordrecht
- Publisher
- Springer
- Date of Publication
- c2011
- Physical Description
- 1 online resource (xxi, 434 p.)
- Series Vol.
- v. 1
- Series Title
- Tumors of the central nervous system
- ISBN
- 9789400703445
- 9789400703438 (print ed.)
- Subjects (MeSH)
- Antineoplastic Agents - therapeutic use
- Biomarkers
- Brain neoplasms - diagnosis
- Brain neoplasms - therapy
- Glioblastoma - diagnosis
- Glioblastoma - therapy
- Glioma - diagnosis
- Glioma - therapy
- Abstract
- The most recent developments in diagnostic and therapeutic aspects of Gliomas (Glioblastoma) in the brain are presented. The importance of personalized medicine and clinical validation for targeted therapy are discussed. The identification of various types of biomarkers is included. The identification and validation of brain cancer (glioblastoma) genes are discussed. Role of cancer stem cells in the initiation, progression, and persistence of malignant gliomas is explained. The use of surgical resection, chemotherapy (e.g., temozolomide), immunotherapy, and radiotherapy for malignant glioblastoma are pointed out. Standard (established) as well as newer imaging modalities (proton magnetic resonance spectroscopy) are discussed.
- Contents
- Part I. Introduction -- 1. Introduction -- 2. Molecular Classification of Gliomas -- Part II. Biomarkers and Diagnosis -- 3. Glioblastoma: Endosialin Marker for Pericytes -- 4. Glioma Grading Using Cerebral Blood Volume Heterogeneity -- 5. The Role of Ectonucleotidases in Glioma Cell Proliferation -- 6. Gliomas: Role of Monoamine Oxidase B in Diagnosis -- 7. Glioma: Role of Integrin in Pathogenesis and Therapy -- 8. Proton Magnetic Resonance Spectroscopy in Intracranial Gliomas -- 9. Infiltration Zone in Glioma: Proton Magnetic Resonance Spectroscopic Imaging -- 10. Malignant Gliomas: Role of E2F1 Transcription Factor -- 11. The Role of Glucose Transporter-1 (GLUT-1) in Malignant Gliomas -- 12. Malignant Gliomas: Role of Platelet-Derived Growth Factor Receptor A (PDGFRA) -- 13. Molecular Methods for Detection of Tumor Markers in Glioblastomas -- 14. Role of MGMT in Glioblastomas -- 15. Glioblastomas: Role of CXCL12 Chemokine -- 16. Cell Death Signaling in Glioblastoma Multiforme: Role of the Bcl2L12 Oncoprotein -- 17. Glioblastoma Multiforme: Role of Polycomb Group Proteins -- 18. Glioblastoma Multiforme: Role of Cell Cycle-Related Kinase Protein (Method) -- Part III. Neural Stem Cells and Cancer Stem Cells -- 19. Markers of Stem Cells in Gliomas -- 20. Efficient Derivation and Propagation of Glioblastoma Stem-Like Cells Under Serum-Free Conditions Using the Cambridge Protocol -- 21. Glioma Cell Lines: Role of Cancer Stem Cells -- 22. Glioblastoma Cancer Stem Cells: Response to Epidermal Growth Factor Receptor Kinase Inhibitors -- Part IV. Therapy -- 23. Low- and High-Grade Gliomas: Extensive Surgical Resection -- 24. Brainstem Gangliogliomas: Total Resection and Close Follow-Up -- 25. Glioblastoma: Temozolomide-Based Chemotherapy -- 26. Drug-Resistant Glioma: Treatment with Imatinib Mesylate and Chlorimipramine -- 27. Glioblastoma Multiforme: Molecular Basis of Resistance to Erlotinib -- 28. Enhanced Glioma Chemosensitivity -- 29 Malignant Glioma Patients: Anti-Vascular Endothelial Growth Factor Monoclonal Antibody, Bevacizumab -- 30. Aggravating Endoplasmic Reticulum Stress by Combined Application of Bortezomib and Celecoxib as a Novel Therapeutic Strategy for Glioblastoma -- 31. Targeted Therapy for Malignant Gliomas -- 32. Glioblastomas: HER1/EGFR-Targeted Therapeutics -- 33. Epidermal Growth Factor Receptor Inhibition as a Therapeutic Strategy for Glioblastoma Multiforme -- 34. Role of Acyl-CoA Synthetases in Glioma Cell Survival and Its Therapeutic Implication -- 35. Malignant Glioma Patients: Combined Treatment with Radiation and Fotemustine -- 36. Malignant Glioma Immunotherapy: A Peptide Vaccine from Bench to Bedside -- 37. Malignant Glioma: Chemovirotherapy -- 38. Intracranial Glioma: Delivery of an Oncolytic Adenovirus -- 39. Use of Magnetic Resonance Spectroscopy Imaging (MRSI) in the Treatment Planning of Gliomas -- 40. Malignant Glioma Cells: Role of Trail-Induced Apoptosis -- Part V. Prognosis -- 41. Long-Term Survivors of Glioblastoma -- 42. Glioblastoma Patients: p15 Methylation as a Prognostic Factor.
- Format
- e-Book
- Location
- Online
Tumors of the Central Nervous System. Vol. 2, Gliomas, Glioblastoma (Part 2)
https://libcat.nshealth.ca/en/permalink/provcat40904
edited by M.A. Hayat.
--Dordrecht:
Springer
, c2011.
- Available Online
- View e-Book
- Location
- Online
Advantages and limitations of biomarkers in gliomagenesis are described. Molecular subtypes of gliomas are detailed. The role played by TP53 gene mutation in the deadliest brain tumor, glioblastoma multiforme, is pointed out. The role of mutations of IDH1 and IDH2, and isocitrate dehydrogenases in malignant gliomas are presented. Metabolic differences in different regions of the glioma tumor are clarified. Various types of imaging modalities, including PET and SPECT, to diagnose gliomas in gene…
- Available Online
- View e-Book
- Other Authors
- Hayat, M.A
- Responsibility
- edited by M.A. Hayat
- Place of Publication
- Dordrecht
- Publisher
- Springer
- Date of Publication
- c2011
- Physical Description
- 1 online resource (xxi, 458 p.)
- Series Vol.
- v. 2
- Series Title
- Tumors of the central nervous system
- ISBN
- 9789400706187
- 9789400706170 (print ed.)
- Subjects (MeSH)
- Antineoplastic Agents - therapeutic use
- Biomarkers
- Brain neoplasms - diagnosis
- Brain neoplasms - therapy
- Glioblastoma - diagnosis
- Glioblastoma - therapy
- Glioma - diagnosis
- Glioma - therapy
- Abstract
- Advantages and limitations of biomarkers in gliomagenesis are described. Molecular subtypes of gliomas are detailed. The role played by TP53 gene mutation in the deadliest brain tumor, glioblastoma multiforme, is pointed out. The role of mutations of IDH1 and IDH2, and isocitrate dehydrogenases in malignant gliomas are presented. Metabolic differences in different regions of the glioma tumor are clarified. Various types of imaging modalities, including PET and SPECT, to diagnose gliomas in general and glioblastoma in particular in patients are explained in detail. Both low-grade and high-grade gliomas are discussed. Conventional as well as fluorescent-guided resection techniques for high-grade, recurrent malignant gliomas are detailed. Impact of resection extent on outcomes in patients with high-grade gliomas is clarified. The advantage of the use of intraoperative low-field MRI in glioma surgery is explained.
- Contents
- 1. Introduction -- Part I. Biomarkers and Diagnosis -- 2. Gliomagenesis: Advantages and Limitations of Biomarkers -- 3. Molecular Subtypes of Gliomas -- 4. Glioblastoma: Germline Mutation of TP53 -- 5. Familial Gliomas: Role of TP53 Gene -- 6. The Role of IDH1 and IDH2 Mutations in Malignant Gliomas -- 7. Malignant Glioma: Isocitrate Dehydrogenases 1 and 2 Mutations -- 8. Metabolic Differences in Different Regions of Glioma Samples -- 9. Glioblastoma Patients: Role of Methylated MGMT -- 10. Brain Tumor Angiogenesis and Glioma Grading: Role of Tumor Blood Volume and Permeability Estimates Using Perfusion CT -- 11. Vasculogenic Mimicry in Glioma -- 12. Newly Diagnosed Glioma: Diagnosis Using Positron Emission Tomography with Methionine and Fluorothymidine -- 13. Role of Diffusion Tensor Imaging in Differentiation of Glioblastomas from Solitary Brain Metastases -- 14. 131I-TM-601 SPECT imaging of Human Glioma -- 15. Assessment of Biological Target Volume Using Positron Emission Tomography in High-Grade Glioma Patients -- 16. Skin Metastases of Glioblastoma -- Part II. Therapy -- 17. Diffuse Low-Grade Gliomas: What Does “Complete Resection” Mean? -- 18. Quantitative Approach of the Natural Course of Diffuse Low-Grade Gliomas -- 19. Impact of Extent of Resection on Outcomes in Patients with High-Grade Gliomas -- 20. Glioma Surgery: Intraoperative Low Field Magnetic Resonance Imaging -- 21. Low-Grade Gliomas: Intraoperative Electrical Stimulations -- 22. Malignant Gliomas: Present and Future Therapeutic Drugs -- 23. Recurrent Malignant Glioma Patients: Treatment with Conformal Radiotherapy and Systemic Therapy -- 24 Glioblastoma: Boron Neutron Capture Therapy -- 25. Glioblastoma: Anti-tumor Action of Cyclosporin A and Functionally Related Drugs -- 26. Glioblastoma Patients: Chemotherapy with Cisplatin, Temozolomide and Thalidomide -- 27. Glioblastoma: Role of Galectin-1 in Chemoresistance -- 28. Glioma-Initiating Cells: Interferon Treatment -- 29. Glioblastoma: Anti-tumor Action of Natural and Synthetic Cannabinoids -- 30. Patients with Recurrent High-Grade Glioma: Therapy with Combination of Bevacizumab and Irinotecan --- 31. Monitoring Gliomas In Vivo Using Diffusion-Weighted MRI During Gene Therapy-Induced Apoptosis -- 32. High-Grade Gliomas: Dendritic Cell Therapy -- 33. Glioblastoma Multiforme: Use of Adenoviral Vectors -- 34. Fischer/F98 Glioma Model: Methodology -- 35. Cellular and Molecular Characterization of Anti-VEGF and IL-6 Therapy in Experimental Glioma -- 36. Adult Brainstem Gliomas: Diagnosis and Treatment -- 37. The Use of Low Molecular Weight Heparin in the Treatment and Prevention of Thromboembolic Disease in Glioma Patients -- Part III. Prognosis -- 38. Brainstem Gliomas: An Overview -- 39. Tumor-Associated Epilepsy in Patients with Glioma -- 40. Brain Tumors Arising in the Setting of Chronic Epilepsy -- 41. Low-Grade Gliomas: Role of Relative Cerebral Blood Volume in Malignant Transformation -- 42. Angiocentric Glioma-Induced Seizures: Lesionectomy.
- Format
- e-Book
- Location
- Online
