Brain and Heart Dynamics
https://libcat.nshealth.ca/en/permalink/provcat44587
Stefano Govoni, Pierluigi Politi, Emilio Vanoli, editors.
--Cham:
Springer
, c2020.
- Available Online
- View e-Book
- Location
- Online
This ambitious and comprehensive manual represents an essential contribution to our current understanding of interactions between heart and brain, a research topic generating growing interest. Despite the increasing awareness that neural mechanisms are the primary cause of cardiac disease and its progression, therapy continues to focus on end-organ protection and does not approach the neural core of the problem. Growing public health problems such as heart failure are still treated with autonom…
- Available Online
- View e-Book
- Other Authors
- Govoni, Stefano
- Politi, Pierluigi
- Vanoli, Emilio
- Responsibility
- Stefano Govoni, Pierluigi Politi, Emilio Vanoli, editors
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2020
- Physical Description
- 1 online resource
- Series Title
- Springer reference
- ISBN
- 9783319903057
- Specialty
- Cardiology
- Neurology
- Physiology
- Notes
- "Living reference work."
- Abstract
- This ambitious and comprehensive manual represents an essential contribution to our current understanding of interactions between heart and brain, a research topic generating growing interest. Despite the increasing awareness that neural mechanisms are the primary cause of cardiac disease and its progression, therapy continues to focus on end-organ protection and does not approach the neural core of the problem. Growing public health problems such as heart failure are still treated with autonomic drugs that are 30-40 years old and simply act on cardiac receptors. However, it has now been shown that the progression of ischemic heart disease to heart failure is mainly due to abnormal central responses to incipient cardiac disease, with neural activation the primary cause rather than the consequence of cardiac remodeling. Written by leading international experts in their respective research areas, it presents a variety of perspectives on the core topic: from social and philosophical to gender-related aspects. Designed for a broad readership, it includes dedicated sections for cardiologists, psychiatrists, neurologists and psychotherapists looking for a more insightful and targeted approach to neuro-cardiovascular disease.
- Contents
- Analgesic Control During Acute Pain to Protect Heart Function -- Biofeedback -- Brain-Heart Communication -- Cognitive Decline in Elderly Patients with Hypertensive Heart Disease -- Consequences of Altered Cardiac Activity on Brain Activity -- Dementia and Cerebrovascular Disease -- Depression and Cardiovascular Diseases -- Distinguishing Cardiac from Psychological Somatic Symptoms -- Epilepsy and Cardiovascular Function -- Headache and the Heart -- Heart and Embolic Stroke of Undetermined Source -- Neural Effects on Cardiac Electrophysiology -- Nicotine and Cardiovascular Function -- Night, Darkness, Sleep, and Cardiovascular Activity -- Osteopathic Pain Management and Cardiovascular Diseases -- Physiological Sleep and Cardiovascular Disease -- Sleep Disorders and Cardiovascular Disease -- The Heart-Brain Connection in Patients with Duchenne Muscular Dystrophy -- The Relationship Between Psychological Distress and Bio-Behavioral Processes in Cardiovascular Disease -- When the Heart Hurts.
- Format
- e-Book
- Location
- Online
Cardiovascular Endocrinology : Shared Pathways and Clinical Crossroads
https://libcat.nshealth.ca/en/permalink/provcat29809
edited by Vivian A. Fonseca.
--Totowa, NJ:
Humana Press
, c2009.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Author
- Fonseca, Vivian A
- Responsibility
- edited by Vivian A. Fonseca
- Place of Publication
- Totowa, NJ
- Publisher
- Humana Press
- Date of Publication
- c2009
- Series Title
- Contemporary endocrinology (Totowa, N.J.)
- ISBN
- 9781597451413
- Subjects (MeSH)
- Cardiovascular Diseases - etiology
- Diabetes Complications
- Endocrine System Diseases - complications
- Hormones - adverse effects
- Format
- e-Book
- Location
- Online
Cardiovascular Safety in Drug Development and Therapeutic Use : New Methodologies and Evolving Regulatory Landscapes
https://libcat.nshealth.ca/en/permalink/provcat41365
J. Rick Turner, Dilip R. Karnad, Snehal Kothari.
--Cham:
Adis
, 2017.
- Available Online
- View e-Book
- Location
- Online
With the advent of multiple new therapeutic agents for a variety of important diseases has come an increasing realization that many of these drugs can have adverse effects on the heart and vascular system. As this book so elegantly details the mechanisms by which harm occurs are highly complex, many times predictable, but always clinically relevant. Notable experts in the field of cardiovascular medicine, such as Drs. Turner, Karnad, and Kothari, have turned their attention to this thorny probl…
- Available Online
- View e-Book
- Author
- Turner, J. Rick
- Other Authors
- Karnad, Dilip R.
- Kothari, Snehal
- Responsibility
- J. Rick Turner, Dilip R. Karnad, Snehal Kothari
- Place of Publication
- Cham
- Publisher
- Adis
- Date of Publication
- 2017
- Physical Description
- 1 online resource (xxvi, 342 pages) : 2 illus. in color
- ISBN
- 9783319403472
- 9783319403458 (print ed.)
- Subjects (MeSH)
- Cardiotoxicity - prevention & control
- Cardiovascular Diseases - etiology
- Drug Design
- Drug Evaluation, Preclinical
- Abstract
- With the advent of multiple new therapeutic agents for a variety of important diseases has come an increasing realization that many of these drugs can have adverse effects on the heart and vascular system. As this book so elegantly details the mechanisms by which harm occurs are highly complex, many times predictable, but always clinically relevant. Notable experts in the field of cardiovascular medicine, such as Drs. Turner, Karnad, and Kothari, have turned their attention to this thorny problem, and begun to dissect the diverse mechanisms by which cardiac harm can occur with a variety of non-cardiac drugs. This is no easy task, given the complexity of the diseases we treat, and the wide spectrum of new therapies we seek to apply. However, it is an issue with which all health care providers must become familiar in order to prescribe appropriate therapy while safeguarding patients against avoidable and life-threatening cardiac adverse effects. This compendium represents the state-of-the-art in the evolving field of cardiac safety and is vital reading for those interested in developing new chemical entities, as well as those who prescribe them and monitor patients for their hazard. As such, I recommend this book as essential reading for students, scientists, and health care providers at all levels of training. Peter R. Kowey, MD, FACC, FAHA, FHRS Lankenau Institute for Medical Research & Thomas Jefferson University.
- Contents
- Part: I Introduction -- 1. The Central Role of Cardiovascular Safety in Drug Development and Therapeutic Use -- Part II: A Primer of Biological and Physiological Considerations -- 2. Drug Structures and the Biological Basis of Drug Responses -- 3. Cardiovascular Structure, Function, and Pathophysiology -- Part III: A Primer of Statistical Considerations -- 4. Analyzing and Reporting Efficacy Data -- 5. Analyzing and Reporting Safety Data -- 6. Meta-analysis, Group Sequential Study Designs, Centralized Endpoint Adjudication, and Composite Endpoints -- Part IV: Proarrhythmic Cardiac Safety -- 7. The Proarrhythmic Cardiac Safety Regulatory Landscape Circa 2005–2015: Drug-Induced hERG Channel Block and the Thorough QT/QTc Study -- 8. QTc Exposure–Response Modeling as a Primary Methodology for Proarrhythmic Cardiac Safety Assessments -- 9. The Comprehensive In Vitro Proarrhythmia Assay Initiative -- Part V: Additional Domains of Cardiovascular Safety -- 10. Oncology Drug Therapy: Cardiotoxicity and the Discipline of Cardio-oncology -- 11. Blood Pressure Responses to Noncardiovascular Drugs in Development and Therapeutic Use -- 12. The Genesis of Cardiovascular Safety Regulatory Landscapes for New Antidiabetic Drugs for Type 2 Diabetes -- 13. Satisfying the Regulatory Requirements for New Antidiabetic Drugs for Type 2 Diabetes Most -- Part VI: Additional Considerations in General Drug Safety and Therapeutic Use -- 14. Postmarketing Cardiovascular Safety Considerations -- 15. A Safety Perspective on Additional Aspects of Drug Development and Therapeutic Use -- Afterword.
- Format
- e-Book
- Location
- Online
Clinical Guide to Cardiovascular Disease
https://libcat.nshealth.ca/en/permalink/provcat41056
Vincent E. Friedewald.
--London:
Springer
, c2016.
- Available Online
- View e-Book
- Location
- Online
This guide is an essential tool to aid the clinician in the efficient management of adult patients with disorders of the heart and blood vessels. The content is designed for use by all health professionals caring for persons with cardiovascular conditions, ranging from the most common, such as systemic arterial hypertension and atrial fibrillation, to the most rare conditions, such as Brugada Syndrome and atrial giant cell myocarditis. The pages are rich in information that will aid both cardio…
- Available Online
- View e-Book
- Author
- Friedewald, Vincent E
- Responsibility
- Vincent E. Friedewald
- Place of Publication
- London
- Publisher
- Springer
- Date of Publication
- c2016
- Physical Description
- 1 online resource (xxiii, 1318 p.) : 2 illus.
- ISBN
- 9781447172932
- 9781447172918 (print ed.)
- Subjects (MeSH)
- Cardiovascular Diseases - etiology
- Cardiovascular Diseases - diagnosis
- Cardiovascular Diseases - therapy
- Abstract
- This guide is an essential tool to aid the clinician in the efficient management of adult patients with disorders of the heart and blood vessels. The content is designed for use by all health professionals caring for persons with cardiovascular conditions, ranging from the most common, such as systemic arterial hypertension and atrial fibrillation, to the most rare conditions, such as Brugada Syndrome and atrial giant cell myocarditis. The pages are rich in information that will aid both cardiovascular specialists as well as primary care/family medicine physicians and nurse practitioners, whose practices are composed of up to 50% of patients with at least one form of cardiovascular disease. In this book, the author has collated current diagnostic criteria for all primary adult cardiovascular disorders. The book assists as a point of care reference by combining established principles of disease management protocols with effective differential diagnosis algorithms. Unlike traditional books, Clinical Guide to Cardiovascular Disease is specifically designed for rapid access to disease information, segregated into keyword data elements organized under 20 separate headings relevant to clinical care. In addition, external links to key articles, Guidelines, patient information, and supplemental and updated information are provided for every condition.
- Contents
- Section I: Cardiovascular diseases -- Section II: Etiology of cardiovascular diseases -- Section III: Predisposing conditions -- Section IV: Signs and Symptoms -- Section V: Differential diagnosis -- Section VI: Complications -- Section VII: Laboratory, imaging and other tests -- Section VIII: Treatment.
- Format
- e-Book
- Publication Type
- Handbook
- Practice Guideline
- Location
- Online
Diabetes and Cardiovascular Disease
https://libcat.nshealth.ca/en/permalink/provcat30146
edited by Michael T. Johnstone, Aristidis Veves.
(2nd ed.)
--Totowa, NJ:
Humana Press
, c2005.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Author
- Johnstone, Michael T
- Other Authors
- Veves, Aristidis
- Responsibility
- edited by Michael T. Johnstone, Aristidis Veves
- Edition
- 2nd ed.
- Place of Publication
- Totowa, NJ
- Publisher
- Humana Press
- Date of Publication
- c2005
- Series Title
- Contemporary cardiology (Totowa, N.J. : Unnumbered)
- ISBN
- 9781592599080
- Subjects (LCSH)
- Diabetes
- Cardiology
- Format
- e-Book
- Location
- Online
Diabetes and cardiovascular disease
https://libcat.nshealth.ca/en/permalink/provcat22407
Johnstone, Michael T.
(2nd ed)
--Totowa, NJ:
Humana Press
, 2005.
- Call Number
- WK 835 D533 2005
- Location
- Halifax Infirmary
- Call Number
- WK 835 D533 2005
- Author
- Johnstone, Michael T
- Other Authors
- Veves, Aristidis
- Edition
- 2nd ed
- Place of Publication
- Totowa, NJ
- Publisher
- Humana Press
- Date of Publication
- 2005
- Physical Description
- 641 p.
- Series Title
- Contemporary cardiology (Totowa, N.J. : Unnumbered)
- ISBN
- 1588294137
- Format
- Book
- Location
- Halifax Infirmary
- Loan Period
- 3 weeks
Diabetic cardiology
https://libcat.nshealth.ca/en/permalink/provcat27685
Fisher, Miles.
--Hoboken, NJ:
John Wiley & Sons
, 2007.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Author
- Fisher, Miles
- Other Authors
- McMurrary, John
- Place of Publication
- Hoboken, NJ
- Publisher
- John Wiley & Sons
- Date of Publication
- 2007
- ISBN
- 9780470723807
- Subjects (MeSH)
- Cardiovascular Diseases - etiology
- Cardiovascular Diseases - therapy
- Diabetes Complications
- Diabetes Mellitus - therapy
- Contents
- Epidemiology of vascular disease in diabetes / Susan Laing -- Pathogenesis of atherosclerosis and vascular disease in type 2 diabetes / Naveed Sattar and Alistair Cormack -- Coronary heart disease and diabetes / Colin Berry, Miles Fisher, and John McMurray -- Diabetes and acute coronary syndromes / Colin Berry, Miles Fisher, and John McMurray -- Diabetes, left ventricular systolic dysfunction, and chronic heart failure / Michael R. MacDonald ... [et al.] -- Diabetes and hypertension / Gordon T. McInnes -- Diabetes and strokes/transient ischaemic attacks / Christopher S. Gray and Janice E. O'Connell -- Diabetes and peripheral arterial disease / Iskandar Idris and Richard Donnelly -- Prevention of cardiovascular events in diabetic patients / Markku Laakso -- Prevention of diabetes as a means of preventing cardiovascular disease / Stephen J. Cleland and Jonathan Shaw -- Diabetes for cardiologists / David MacFarlane, Colin Perry, and Miles Fisher.
- Format
- e-Book
- Location
- Online
Epicardial Adipose Tissue : From Cell to Clinic
https://libcat.nshealth.ca/en/permalink/provcat45391
Gianluca Iacobellis, editor.
--Cham:
Humana Press
, c2020.
- Available Online
- View e-Book
- Location
- Online
This book is the first authoritative and comprehensive volume dedicated to epicardial adipose tissue (EAT). It provides an up-to-date and highly illustrated synopsis of the anatomical, biomolecular, genetic, imaging features, and clinical applications of EAT and its role in cardiovascular disease. It relays to the reader a contemporary view of the emerging interplay between the heart and adiposity-related diseases. In addition, this volume discusses the clinical implications and therapeutic tar…
- Available Online
- View e-Book
- Other Authors
- Iacobellis, Gianluca
- Responsibility
- Gianluca Iacobellis, editor
- Place of Publication
- Cham
- Publisher
- Humana Press
- Date of Publication
- c2020
- Physical Description
- 1 online resource (xiv, 191 p.) : 45 illus., 40 illus. in color
- Series Title
- Contemporary cardiology
- ISBN
- 9783030405700
- 9783030405694 (Print ed.)
- 9783030405717 (Print ed.)
- 9783030405724 (Print ed.)
- ISSN
- 2196-8969
- Subjects (MeSH)
- Adipose Tissue - diagnostic imaging
- Adipose Tissue - physiopathology
- Cardiovascular Diseases - etiology
- Specialty
- Cardiology
- Pathology
- Abstract
- This book is the first authoritative and comprehensive volume dedicated to epicardial adipose tissue (EAT). It provides an up-to-date and highly illustrated synopsis of the anatomical, biomolecular, genetic, imaging features, and clinical applications of EAT and its role in cardiovascular disease. It relays to the reader a contemporary view of the emerging interplay between the heart and adiposity-related diseases. In addition, this volume discusses the clinical implications and therapeutic targets of EAT in atrial fibrillation, heart failure and coronary artery disease. Comprehensive yet focused, Epicardial Adipose Tissue: From Cell to Clinic is an essential resource for physicians, residents, fellows, and medical students in cardiology, endocrinology, primary care, and health promotion and disease prevention.
- Contents
- 1. Anatomy of the Epicardial Adipose Tissue -- 2. Physiology and Cardioprotection of the Epicardial Adipose Tissue -- 3. Transcriptomic and Proteomic Analysis of the Epicardial Adipose Tissue -- 4. Pathology and Cardiotoxicity of the Epicardial Adipose Tissue -- 5. Echocardiographic Imaging of the Epicardial Adipose Tissue -- 6. Computed Tomography Imaging of Epicardial Adipose Tissue -- 7. Magnetic Resonance Imaging of the Epicardial Adipose Tissue -- 8. Coronary Artery Disease and Epicardial Adipose Tissue -- 9. Perivascular Adipose Tissue and Atherosclerosis -- 10. Atrial Fibrillation and Epicardial Adipose Tissue -- 11. Heart Failure and Epicardial Adipose Tissue -- 12. Autonomic Nervous System Modulation of the Epicardial Adipose Tissue in Heart Failure and Atrial Fibrillation -- 13. Cardiometabolic Risk and Epicardial Adipose Tissue -- 14. Adrenal Secretome and Epicardial Adipose Tissue -- 15. Targeting the Epicardial Adipose Tissue.
- Format
- e-Book
- Location
- Online
Gender Differences in the Pathogenesis and Management of Heart Disease
https://libcat.nshealth.ca/en/permalink/provcat42570
Jawahar L. Mehta, Jean McSweeney, editors.
--Cham:
Springer
, c2018.
- Available Online
- View e-Book
- Location
- Online
This book reviews all aspects of the diagnosis and management of heart disease in women, covering areas such as gender differences in metabolic syndrome, hypertension and atherogenesis. Gender differences in cardiovascular diseasesáare widespread, but while gender medicine takes into account the effects of sex and gender on the health of women and men, traditionally, women have been underrepresented in cardiovascular clinical trials, in management of different cardiac diseases and drug use. Gen…
- Available Online
- View e-Book
- Other Authors
- Mehta, Jawahar L.
- McSweeney, Jean
- Responsibility
- Jawahar L. Mehta, Jean McSweeney, editors
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2018
- Physical Description
- 1 online resource (xii, 361 p.) : 22 illus., 17 illus. in color
- ISBN
- 9783319711355
- 9783319711348 (print ed.)
- 9783319711362 (print ed.)
- Subjects (MeSH)
- Cardiovascular Diseases - etiology
- Cardiovascular Diseases - therapy
- Risk Factors
- Sex Factors
- Specialty
- Cardiology
- Abstract
- This book reviews all aspects of the diagnosis and management of heart disease in women, covering areas such as gender differences in metabolic syndrome, hypertension and atherogenesis. Gender differences in cardiovascular diseasesáare widespread, but while gender medicine takes into account the effects of sex and gender on the health of women and men, traditionally, women have been underrepresented in cardiovascular clinical trials, in management of different cardiac diseases and drug use. Gender Differences in the Pathogenesis and Management of Heart Diseaseádeals with the gender-specific differences in cardiac physiology and diseases and brings into perspective the critical significance of gender in management of cardiovascular disease presentations and management. As such it is of enormous use to all clinical staff who manage women with cardiovascular disease.
- Contents
- 1. Atherosclerosis and Gender-Related Differences -- 2. Gender Differences in Metabolic Syndrome -- 3. Hypertension in Women -- 4. Sex-Based Differences in Risk Determinants and Management of Heart Failure -- 5. Gender Differences in Cardiomyopathies -- 6. Cardiovascular Risks of Impaired Fertility and Assisted Reproductive Therapy -- 7. Gender Differences in the Gut Microbiome and How These Affect Cardiovascular Diseases -- 8. Angina and Ischemia in Women with No Obstructive Coronary Artery Disease -- 9. Microvascular Angina as a Cause of Ischemia: An Update -- 10. Gender and Racial/Ethnic Differences in CVD Risk: Behavioral and Psychosocial Risk and Resilience -- 11. Sex-Specific Differences in Acute Myocardial Infarction -- 12. The Prevention, Diagnosis and Treatment of Ischemic Heart Disease in Women -- 13. Gender Differences in Outcome After Coronary Revascularization -- 14. Sex Differences in Cardiac Arrhythmias -- 15. Gender Differences in Atrial Fibrillation: Incidence, Mechanistic Basis of the Differences and Treatment Options -- 16. Gender Differences in Cardiovascular Drugs -- 17. Cardiovascular Side Effects of Breast Cancer Therapy -- 18. Burden of Cardiovascular Diseases in Women and Reduction Strategies in India -- 19. Regional Differences in HD in Women.
- Format
- e-Book
- Location
- Online
Handbook of Cardiovascular Disease Management in Rheumatoid Arthritis
https://libcat.nshealth.ca/en/permalink/provcat41280
Anne Grete Semb, editor.
--Cham:
Adis
, 2017.
- Available Online
- View e-Book
- Location
- Online
This book is a practical and up-to-date review that discusses the impact of traditional cardiovascular risk factors in patients with rheumatoid arthritis, the effect of rheumatoid arthritis disease activity and severity on cardiovascular comorbidity, and the influence of rheumatoid arthritis drug therapy on cardiovascular risk. This title also explores cardiovascular disease as a manifestation of rheumatoid arthritis and highlights the available methods for screening and diagnosing these condit…
- Available Online
- View e-Book
- Other Authors
- Semb, Anne Grete
- Responsibility
- Anne Grete Semb, editor
- Place of Publication
- Cham
- Publisher
- Adis
- Date of Publication
- 2017
- Physical Description
- 1 online resource (xvi, 109 pages) : 28 illus., 16 illus. in color
- ISBN
- 9783319267821
- 9783319267807 (print ed.)
- Subjects (MeSH)
- Arthritis, Rheumatoid - complications
- Cardiovascular Diseases - etiology
- Cardiovascular Diseases - therapy
- Risk Factors
- Abstract
- This book is a practical and up-to-date review that discusses the impact of traditional cardiovascular risk factors in patients with rheumatoid arthritis, the effect of rheumatoid arthritis disease activity and severity on cardiovascular comorbidity, and the influence of rheumatoid arthritis drug therapy on cardiovascular risk. This title also explores cardiovascular disease as a manifestation of rheumatoid arthritis and highlights the available methods for screening and diagnosing these conditions. Current and emerging therapies to aid clinicians in the daily management of their patients are also featured in this title. Busy healthcare professionals who are looking for a collaborative approach to these conditions will benefit from this comprehensive overview.
- Contents
- 1. Overview of rheumatoid arthritis and mortality in relation to cardiovascular disease -- 2. Non-atherosclerotic cardiac manifestations of rheumatoid arthritis -- 3. Risk factors for cardiovascular disease in rheumatoid arthritis -- 4. Cardiovascular disease risk evaluation -- 5. Pharmacological management of cardiovascular disease in patients with rheumatoid arthritis -- 6. Non-pharmacological interventions for cardiovascular complications in patients with rheumatoid arthritis -- 7. Conclusions. .
- Format
- e-Book
- Location
- Online
Managing cardiometabolic risk : an evolving approach to patient care
https://libcat.nshealth.ca/en/permalink/provcat22972
Watson, Karol.
--[s.l.]:
Sanofi Aventis
, 2006.
- Call Number
- WG 120 M266 2006
- Location
- Halifax Infirmary
- Call Number
- WG 120 M266 2006
- Author
- Watson, Karol
- Place of Publication
- [s.l.]
- Publisher
- Sanofi Aventis
- Date of Publication
- 2006
- Physical Description
- 24 p.
- Subjects (MeSH)
- Cardiovascular System - metabolism
- Cardiovascular Diseases - etiology
- Cardiovascular Diseases - prevention & control
- Format
- Book
- Location
- Halifax Infirmary
- Loan Period
- 3 weeks
Mitochondria and their role in cardiovascular disease
https://libcat.nshealth.ca/en/permalink/provcat32396
by José Marín-García ; with contributions by Alexander Akhmedov and Vitalyi Rybin, Gordon W. Moe.
--New York, NY:
Springer
, c2013.
- Available Online
- View e-Book
- Location
- Online
Over the past two decades, due to dramatic advances in molecular and cell biology, biochemistry, and genetics, our view on mitochondria as a relatively static cellular powerhouse has changed radically. We now know that these organelles play a critical role in the normal and in the damaged heart. Written by Dr. José Marín-García, Director of the Molecular Cardiology and Neuromuscular Institute, Mitochondria and Their Role in Cardiovascular Disease brings readers up- to-date on the many significa…
- Available Online
- View e-Book
- Author
- Marín-García, José
- Responsibility
- by José Marín-García ; with contributions by Alexander Akhmedov and Vitalyi Rybin, Gordon W. Moe
- Place of Publication
- New York, NY
- Publisher
- Springer
- Date of Publication
- c2013
- Physical Description
- 1 online resource (xix, 500 p. : 123 ill., 115 ill. in color)
- ISBN
- 9781461445999
- Subjects (MeSH)
- Cardiovascular Diseases - etiology
- Cardiovascular Diseases - physiopathology
- Mitochondria, Heart - metabolism
- Myocardium - metabolism
- Subjects (LCSH)
- Cardiology
- Biochemistry
- Abstract
- Over the past two decades, due to dramatic advances in molecular and cell biology, biochemistry, and genetics, our view on mitochondria as a relatively static cellular powerhouse has changed radically. We now know that these organelles play a critical role in the normal and in the damaged heart. Written by Dr. José Marín-García, Director of the Molecular Cardiology and Neuromuscular Institute, Mitochondria and Their Role in Cardiovascular Disease brings readers up- to-date on the many significant advances in the field of mitochondrial cardiovascular medicine. The book begins with a general introduction to mitochondria, followed by laboratory methods to study the structure and function of the organelle, regulation of replication and biogenesis, and the mechanisms and functional consequences of mitophagia and mitochondrial dynamics. Subsequent chapters deal with mitochondrial oxidative stress and the role that the organelle plays in cell signaling and cell death. Discussions will be undertaken on the biochemistry of mitochondrial cell signaling, including the nature of the proteins engaged in these processes, many of them only recently discovered. Later chapters examine the role of mitochondria and mitochondrial abnormalities in cardiovascular diseases, including their diagnosis, therapeutic options currently available, animal models of mitochondrial disease, and new frontiers in mitochondria cardiovascular medicine, including areas of research that are relatively new or developing, such as proteomics, next generation sequencing, and systems biology.
- Contents
- Introduction to mitochondria in the heart -- Methods to study mitochondrial structure and function- Mitochondrial structure, composition and dynamics -- Mitochondrial biogenesis -- Mechanisms of bioenergy production in mitochondria -- Bioenergetics interplay between cardiac mitochondria and other subcellular compartments -- Endothelial mitochondria: Contribution to cardiovascular function and disease -- Heart mitochondria: Receivers and transmitters of signals -- Stem cells and mitochondria -- Cell death pathways and mitochondria -- Mitochondria in pediatric cardiovascular diseases -- Mitochondrial in the aging heart -- The role of mitochondria in atherosclerosis -- The role of mitochondria in hypertension -- Role of mitochondria in ischemia and cardioprotection -- Mitochondrial dynamics in health and disease -- Mitochondria play an essential role in heart failure -- Mitochondria and cardiac dysrhythmias -- Diabetes and cardiac mitochondria -- The role of mitochondria in metabolic syndrome and insulin resistance.-Thyroid hormone and myocardial mitochondria -- Targeting the mitochondria in cardiovascular diseases -- Current progress and future perspectives: Towards mitochondrial medicine -- Glossary -- Index.
- Format
- e-Book
- Location
- Online
Obesity and cardiovascular disease
https://libcat.nshealth.ca/en/permalink/provcat24583
Iacobellis, Gianluca.
--Oxford, England:
Oxford University Press
, 2009.
- Call Number
- WD 210 I11o 2009
- Location
- Halifax Infirmary
- Call Number
- WD 210 I11o 2009
- Author
- Iacobellis, Gianluca
- Place of Publication
- Oxford, England
- Publisher
- Oxford University Press
- Date of Publication
- 2009
- Physical Description
- 272 p.
- ISBN
- 9780199549320
- Subjects (MeSH)
- Obesity - complications
- Cardiovascular Diseases - etiology
- Format
- Book
- Location
- Halifax Infirmary
- Loan Period
- 3 weeks
Osteocardiology : Cardiac Bone Formation
https://libcat.nshealth.ca/en/permalink/provcat42770
Nalini M. Rajamannan.
--Cham:
Springer
, c2018.
- Available Online
- View e-Book
- Location
- Online
This book describes the field of osteocardiology, an exciting and new sub-discipline within cardiovascular science, which will become the cornerstone for defining the timing and treatment of cardiovascular calcification in the future. With the advent of large cohort databases and experimental mechanistic studies, research has elucidated evidence confirming that traditional cardiovascular risk factors are responsible for the development of atherosclerotic calcification and identified the critica…
- Available Online
- View e-Book
- Author
- Rajamannan, Nalini M.
- Responsibility
- Nalini M. Rajamannan
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2018
- Physical Description
- 1 online resource (xiv, 99 p.) : 22 illus. in color
- ISBN
- 9783319649948
- 9783319649931 (print ed.)
- 9783319649955 (print ed.)
- 9783319879215 (print ed.)
- Subjects (MeSH)
- Cardiovascular Diseases - etiology
- Osteogenesis
- Vascular Calcification - physiopathology
- Specialty
- Cardiology
- Osteology
- Pathology
- Abstract
- This book describes the field of osteocardiology, an exciting and new sub-discipline within cardiovascular science, which will become the cornerstone for defining the timing and treatment of cardiovascular calcification in the future. With the advent of large cohort databases and experimental mechanistic studies, research has elucidated evidence confirming that traditional cardiovascular risk factors are responsible for the development of atherosclerotic calcification and identified the critical elements of atherosclerosis, including foam cell formation, vascular smooth muscle cell proliferation and extracellular matrix synthesis, which over time forms bone in the heart. Osteocardiology: Cardiac Bone Formation is a practical overview of bone formation in the heart and is destined to become the cornerstone for education of medical students, residents, fellows, graduate students, physician scientists and scientists, for future research and ongoing development in medical therapies to slow or halt the progression of bone formation in the heart.
- Contents
- 1. Osteocardiology Risk Factors -- 2. Coronary Artery Calcification -- 3. Osteocardiology: Calcific Aortic Valve Disease -- 4. Osteocardiology: Calcific Aortic Disease -- 5. Osteocardiology: Endochondral Bone Formation -- 6. Osteocardiology: The Atherosclerotic Bone Paradox -- 7. Osteocardiology: Cellular Origins of Cardiac Calcification -- 8. Osteocardiology: LDL-Density-Gene Theory -- 9. Osteocardiology: The LDL-Density-Mechanostat Theory -- 10. Osteocardiology: The Go/No Go Theory For Clinical Trials.
- Format
- e-Book
- Location
- Online
