Ma Vie en Noir : Fifty Years with Melatonin and the Stone of Madness
https://libcat.nshealth.ca/en/permalink/provcat40301
Daniel Pedro Cardinali.
--Cham:
Springer
, c2016.
- Available Online
- View e-Book
- Location
- Online
I wrote this book urged by the overwhelming desire that arises towards the end of life to recapitulate the past. My goal was to summarize my experience of practicing science at the end of the 20th and early 21st centuries in Argentina, a country located far away from the world's leading scientific centers. In the book, I summarize the intricacies of the pineal gland ("the stone of madness") as historical, mystical and medical entity and its entry in contemporary medicine with the description of…
- Available Online
- View e-Book
- Author
- Cardinali, Daniel Pedro
- Responsibility
- Daniel Pedro Cardinali
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2016
- Physical Description
- 1 online resource (xiii, 301 p. : 119 illus., 91 illus. in color)
- Series Title
- Springer Biographies
- ISBN
- 9783319416793
- 9783319416786 (print ed.)
- Subjects (MeSH)
- Chronobiology Discipline - history
- Chronobiology Phenomena
- Chronotherapy
- Melatonin - history
- Melatonin - therapeutic use
- Mental Disorders - history
- Pineal Gland - physiology
- Abstract
- I wrote this book urged by the overwhelming desire that arises towards the end of life to recapitulate the past. My goal was to summarize my experience of practicing science at the end of the 20th and early 21st centuries in Argentina, a country located far away from the world's leading scientific centers. In the book, I summarize the intricacies of the pineal gland ("the stone of madness") as historical, mystical and medical entity and its entry in contemporary medicine with the description of melatonin. I also reflect on how being associated with an unexplored subject at the beginning of their scientific career impacts the life of a scientist throughout their entire life. Today we know that in humans pineal melatonin begins is released every day late in the evening, and there is evidence that it is the trigger for the sleep process. But the most exciting aspect of melatonin is that it is a substance that is present in all living creatures, from unicellular organisms to plants and higher mammals, a fact that evinces its importance for life. Further, the neuroprotective action of melatonin promises to be crucial for the control of neurodegenerative diseases we face as a pandemic in this century. The discoverer of melatonin, Aaron Lerner, based its name on melano, the Greek word for black, because of its effect on the pigment cells of the skin. As in "La vie en rose", the immortal Edith Piaf song written in 1946, my lifelong work with melatonin could well be called "Ma vie en noir".
- Contents
- 1. Brief History of the Stone of Madness -- 2. The Prescientific Stage of the Pineal Gland -- 3. The Beginnings of the Pineal Scientific Era: From the Late Nineteenth Century to Melatonin’s Discovery -- 4. Sleep/Wake Cycle: History and Facts -- 5. When This Chronicler Enters the Story: The 1960s -- 6. The Stone of Madness as a Neuroendocrine Organ and Model: The 1970s -- 7. Peripheral Innervation of Neuroendocrine-Immune System: The Challenges to Change a Physiological Paradigm -- 8. Melatonin as a Potential Therapeutic Agent: The 1980s -- 9. Melatonin as a Chronobiotic That Opens the “Gates of Sleep”: The 1990s -- 10. Melatonin and the “Diseases of the Soul”: The Stone of Madness Returns -- 11. Twenty-First Century: The 24/7 Society as an Environmental Mutation -- 12. Melatonin as a Medicament for the 24/7 Society: Metabolic Syndrome -- 13. Melatonin as a Medicament for the 24/7 Society: Normal and Pathological Aging -- 14. Melatonin as a Medicament for the 24/7 Society: Cancer -- 15. Melatonin as a Nutraceutical -- Epilogue.
- Format
- e-Book
- Location
- Online
Chronomics and Continuous Ambulatory Blood Pressure Monitoring : Vascular Chronomics : From 7-Day/24-Hour to Lifelong Monitoring
https://libcat.nshealth.ca/en/permalink/provcat40386
Kuniaki Otsuka, Germaine Cornelissen, Franz Halberg.
(1st ed.)
--Tokyo:
Springer Japan
, c2016.
- Available Online
- View e-Book
- Location
- Online
This fascinating volume applies the concept of chronomics to the medical treatment of hypertension. It starts with the recent updates on chronomics, the analytic techniques, and their application to community-based assessments. The authors advocate the use of 7-day/24-h records of blood pressure, which is effective for finding masked hypertension, masked morning surge, and other rhythm abnormalities. Most organisms, from cyanobacteria to mammals, are known to use the circadian mechanism. Howeve…
- Available Online
- View e-Book
- Author
- Otsuka, Kuniaki
- Other Authors
- Cornelissen, Germaine
- Halberg, Franz
- Responsibility
- Kuniaki Otsuka, Germaine Cornelissen, Franz Halberg
- Edition
- 1st ed.
- Place of Publication
- Tokyo
- Publisher
- Springer Japan
- Date of Publication
- c2016
- Physical Description
- 1 online resource (lxxv, 870 p. : 644 illus., 275 illus. in color)
- ISBN
- 9784431546313
- 9784431546306 (print ed.)
- Subjects (MeSH)
- Blood Pressure Monitoring, Ambulatory
- Chronobiology Phenomena
- Hypertension
- Abstract
- This fascinating volume applies the concept of chronomics to the medical treatment of hypertension. It starts with the recent updates on chronomics, the analytic techniques, and their application to community-based assessments. The authors advocate the use of 7-day/24-h records of blood pressure, which is effective for finding masked hypertension, masked morning surge, and other rhythm abnormalities. Most organisms, from cyanobacteria to mammals, are known to use the circadian mechanism. However, our body systems also demonstrate circaseptan (roughly weekly), circannual (roughly yearly), and even longer rhythms. Chronomics monitors the physiological data and then analyzes the superimposed rhythms, isolating the cycles mathematically to determine how organisms and their environment interact. It is the study of interactions among time structures (chronomes) in and around us.
- Contents
- 1. From chronobiology to chronomedicine: Days of creation -- 2. From chronomics to chronoastrobiology: Many rhythms are control information for whatever we do -- 3. Chronobioethics: what is life? -- 4. Chronobiology -- 5. Chronomics of heart rate variability -- 6. Chronomics of life for improving the quality of health -- 7. Chronomics of tree rings gauge climate change -- 8. Introduction to Chronobioengineering -- 9. What community-based glocal comprehensive assessment tells us: chronoecology is far superior to evidence-based medicine (EBM) -- 10. Community-based comprehensive geriatric assessment -- 11. Chronomic community screening: depressive mood, heart rate variability and cardiovascular outcomes in a community -- 12. Chronoecological "glocal" (global and local) comprehensive health-watch at high altitude -- 13. Chronoastrobiology -- 14. Heart rate variability reflecting the dynamics of solar activity -- 15. A transdisciplinary near-transyear in sudden cardiac death validates its counterpart in the solar wind and geomagnetics -- 16. Diagnosing vascular variability disorders and vascular variability syndromes -- 17. Among-day blood pressure variability assessed by 7-day/24-hour ambulatory blood pressure monitoring and prognostic value of vascular variability anomalies -- 18. Case presentations I. Within-day BP variations observed using 7-day/24-hour ambulatory BP monitoring -- 19. Case presentations II. Vascular variability syndrome -- 20. Case presentations III. Among-day variability of circadian profiles of 24-hour ABP -- 21. "What is life?" Cycles tipping the scale between death and survival -- 22. Astro-glocal spatially and temporally (global & local) comprehensive health watch especially at high altitude -- 23. Chronobioethics and Alerting Chronobiological Ambulatory Blood Pressure Monitoring (C-ABPM; stress/strain-test) For preventing cardiovascular and for understanding and avoiding/evading societal and natural cataclysms by personalized and generalized chronouspheres -- Closing Remarks.
- Format
- e-Book
- Location
- Online
