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Colitis : A Practical Approach to Colon and Ileum Biopsy Interpretation

https://libcat.nshealth.ca/en/permalink/provcat43077
Anne Jouret-Mourin, Gavino Faa, Karel Geboes, editors. (Second edition) --Cham: Springer , c2018.
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This revised and updated second edition explains how to analyze endoscopic mucosal biopsies of the ileum and colon. As in the first edition, the diagnosis and follow up of colitis in general and inflammatory bowel diseases in particular is covered and this edition also includes new chapters on ileitis and optimal biopsy procedures. The basic lesions are described using multiple drawings together with an explanatory text and endoscopic and histological photographs. A review of various differenti…
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Other Authors
Jouret-Mourin, Anne
Faa, Gavino
Geboes, Karel
Responsibility
Anne Jouret-Mourin, Gavino Faa, Karel Geboes, editors
Edition
Second edition
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2018
Physical Description
1 online resource (x, 255 p.) : 160 illus., 156 illus. in color
ISBN
9783319895031
9783319895024 (print ed.)
9783319895048 (print ed.)
Subjects (MeSH)
Biopsy - methods
Colitis - diagnosis
Colon - pathology
Ileitis - diagnosis
Ileum - pathology
Specialty
Diagnosis
Gastroenterology
Pathology, Surgical
Abstract
This revised and updated second edition explains how to analyze endoscopic mucosal biopsies of the ileum and colon. As in the first edition, the diagnosis and follow up of colitis in general and inflammatory bowel diseases in particular is covered and this edition also includes new chapters on ileitis and optimal biopsy procedures. The basic lesions are described using multiple drawings together with an explanatory text and endoscopic and histological photographs. A review of various differential diagnostic issues and types of colitis is also included. Colitis: A Practical Approach to Colon and Ileum Biopsy Interpretation is aimed at general pathologists and pathologists in training and also gastroenterologists to help them understand how a precise diagnosis can be reached.
Contents
1. Introduction -- 2. The Normal Biopsy: Colonic and Ileal Mucosa and Submucosa -- 3. Endoscopic Mucosal Biopsy Sampling of the Colon and the Terminal Ileum -- 4. Normal Endoscopic Appearance of the Colon and the Terminal Ileum -- 5. The Endoscopic Biopsy: How to Proceed and How to Look at a Biopsy -- 6. Elementary Lesions of Inflammation -- 7. Infectious Colitis -- 8. Inflammatory Bowel Diseases -- 9. Dysplasia in Inflammatory Bowel Disease -- 10. Treatment-Related Conditions -- 11. Drug-Induced Colon Injury -- 12. Diverticular Disease-Associated Colitis -- 13. Ischemic Colitis -- 14. Microscopic Colitis -- 15. Eosinophilic Colitis -- 16. Mucosal Prolapse Syndrome -- 17. Ileitis -- 18. The Role of Biopsies in the Treatment of Colitis: Scoring of Disease Activity.
Format
e-Book
Location
Online
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Crohn's Disease and Ulcerative Colitis : From Epidemiology and Immunobiology to a Rational Diagnostic and Therapeutic Approach

https://libcat.nshealth.ca/en/permalink/provcat30928
Daniel C. Baumgart, editor. --New York, NY: Springer , c2012.
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The conditions of Crohn's disease and ulcerative colitis are excellent examples of how the exponential growth of knowledge in biomedical science can make a remarkable impact on clinical practice and patient's quality of life. It has led to the development of unique novel immunomodulatory treatments. These are continuously being refined to treat not only the two original conditions in the gut, but the systemic immunologic illness with its associated extraintestinal disorders. New therapies are …
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Other Authors
Baumgart, Daniel C
Responsibility
Daniel C. Baumgart, editor
Place of Publication
New York, NY
Publisher
Springer
Date of Publication
c2012
Physical Description
1 online resource (xviii, 754 p. : 151 ill., 116 ill. in color)
ISBN
9781461409984
Subjects (MeSH)
Colitis, Ulcerative
Crohn Disease
Subjects (LCSH)
Gastroenterology
Abstract
The conditions of Crohn's disease and ulcerative colitis are excellent examples of how the exponential growth of knowledge in biomedical science can make a remarkable impact on clinical practice and patient's quality of life. It has led to the development of unique novel immunomodulatory treatments. These are continuously being refined to treat not only the two original conditions in the gut, but the systemic immunologic illness with its associated extraintestinal disorders. New therapies are sometimes complex and associated with important risks requiring a deeper understanding of their molecular principles from clinicians. Crohn's Disease and Ulcerative Colitis serves as a unique combined resource for physicians and scientists addressing the needs of both groups. It will stimulate exchange and collaboration and shorten the path between discovery and application of new knowledge and also help clinicians understand new therapeutic concepts from their origins. This volume provides an introduction to mucosal immunology which forms the basis of modern immunotherapy. It also serves as a comprehensive guide to the current diagnostic modalities, including enhanced imaging techniques such as MRI and CT enterography, virtual colonoscopy, ultrasound, and endomicroscopy as well as conventional and complex immunomodulatory principles. Each chapter is written by experts in their field and includes the most up to date information. Crohn's Disease and Ulcerative Colitis will be of great value to gastroenterologists, surgeons, internists, pediatricians and gynecologists trainees, as well as all those involved in Crohn's disease, ulcerative colitis and related autoimmune disorders.
Contents
The genetics of inflammatory bowel disease -- Environmental factors in the epidemiology of inflammatory bowel disease -- The intestinal immune system in health -- Understanding the epithelial barrier in inflammatory bowel disease -- Intestinal microbiology and ecology in inflammatory bowel disease -- Microbial recognition and pathogen-associated molecular pattern (PAMP) receptors in inflammatory bowel disease -- Inflammasomes in inflammatory bowel disease -- Antimicrobial peptides in inflammatory bowel disease -- Vascular responses to intestinal inflammation in inflammatory bowel disease -- Immunobiology of dendritic cells in inflammatory bowel disease -- Immunobiology of T-Cells in inflammatory bowel disease -- Immunobiology of B-Cells in inflammatory bowel disease -- Immunobiology of monocytes and macrophages in inflammatory bowel disease -- Immunobiology of epithelial cells in inflammatory bowel disease -- The Th1, Th2 and Th17 paradigm in inflammatory bowel disease -- Preclinical studies using mouse models of inflammatory bowel disease -- Enhanced endoscopy in inflammatory bowel disease -- MRI in Inflammatory Bowel Disease -- CT in inflammatory bowel disease -- Ultrasound in inflammatory bowel disease -- Laboratory evaluation including novel diagnostic markers of inflammatory bowel disease -- Histology and pathology of inflammatory bowel disease -- Activity indices based assessment of disease activity in inflammatory bowel disease -- Endoscopic assessment of disease activity and mucosal healing in inflammatory bowel disease -- Evaluation of quality of life in inflammatory bowel disease -- The natural history of inflammatory bowel disease -- Conventional medical management of Crohn's disease: sulfasalazine -- Conventional medical management of Crohn's disease: corticosteroids -- Conventional medical management of Crohn's disease: azathioprine and 6-mercaptopurine -- Conventional medical management of Crohn's Disease: Methotrexate -- Biologic Treatment of Crohn's Disease: Adalimumab -- Biologic Treatment of Crohn's Disease: Certolizumab -- Biologic Therapy of Crohn's disease: Infliximab -- Biologic Treatment of Crohn's Disease: briakinumab and ustekinumab -- Biologic Treatment of Crohn's Disease: natalizumab, vedolizumab and edrolizumab (rHUMab beta 7) -- Conventional medical management of ulcerative colitis: sulfasalazine and 5-aminosalicylates -- Conventional medical management of ulcerative colitis: corticosteroids -- Conventional medical management of ulcerative colitis: azathioprinetherapy: Azathioprine -- Conventional medical management of ulcerative colitis: cyclosporine -- Conventional medical management of ulcerative colitis: tacrolimus -- Biologic therapy of ulcerative colitis: infliximab and adalimumab -- Biologic therapy of ulcerative colitis: natalizumab, vedolizumab, edrolizumab (rHUMab beta 7) -- Probiotics, prebiotics, and antibiotics in medical management inflammatory bowel disease -- Step-Up vs. Top-Down Approach in medical management of inflammatory bowel disease -- Surgical management of Crohn's disease and ulcerative colitis -- Extraintestinal manifestations of inflammatory bowel disease: autoimmune hepatitis -- Extraintestinal manifestations of inflammatory bowel disease: primary sclerosing cholangitis (PSC) -- Extraintestinal manifestations of inflammatory bowel disease: autoimmune pancreatitis and other IgG4-related conditions -- Extraintestinal manifestations of inflammatory bowel disease: cutaneous and oral manifestations of inflammatory bowel disease -- Extraintestinal manifestations of inflammatory bowel disease: arthritis, arthropathy and osteoporosis -- Nutrition in inflammatory bowel disease -- Fertility and pregnancy in inflammatory bowel disease -- Pediatric aspects in inflammatory bowel disease -- Management and prevention of infectious diseases in inflammatory bowel disease patients -- Diagnosis and management of colorectal neoplasia in patients with inflammatory bowel disease -- How to identify high risk patients in inflammatory bowel disease? -- Patient perspective on inflammatory bowel disease -- Patient resources in inflammatory bowel disease.
Format
e-Book
Location
Online
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Fibrostenotic Inflammatory Bowel Disease

https://libcat.nshealth.ca/en/permalink/provcat42704
edited by Florian Rieder. --Cham: Springer , c2018.
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This book provides a comprehensive account of the pathogenesis and treatment of intestinal fibrosis, covering both the clinical and molecular aspects of the disease. It begins by describing the epidemiology and genetics of fibrostenosing IBD in Crohn's disease and Ulcerative colitis as well as the epigenetics and cellular and molecular mechanisms of the disease. Readers will obtain an in-depth overview of the disease from biomarkers and histology to surgical intervention, imaging and current an…
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Other Authors
Rieder, Florian
Responsibility
edited by Florian Rieder
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2018
Physical Description
1 online resource (xii, 397 p.) : 70 illus., 67 illus. in color
ISBN
9783319905785
9783319905778 (print ed.)
9783319905792 (print ed.)
Subjects (MeSH)
Fibrosis
Crohn Disease
Colitis, Ulcerative
Specialty
Gastroenterology
Abstract
This book provides a comprehensive account of the pathogenesis and treatment of intestinal fibrosis, covering both the clinical and molecular aspects of the disease. It begins by describing the epidemiology and genetics of fibrostenosing IBD in Crohn's disease and Ulcerative colitis as well as the epigenetics and cellular and molecular mechanisms of the disease. Readers will obtain an in-depth overview of the disease from biomarkers and histology to surgical intervention, imaging and current and future drug therapies. Medical management of fibrosis, endoscopy and imaging as well as surgical approaches are all discussed. Through the links to videos contained in the book, the reader will become familiar with interventional procedures such as endoscopic balloon dilation and surgical techniques for stricturing IBD, such as resection and strictureplasties. This is an indispensable volume for anyone working on fibrostenotic IBD, such as gastroenterologists, internists, radiologists, colorectal surgeons, pathologists and researchers. It has been written by a team of top experts from North America, Asia and Europe.
Contents
Fibrostenotic Inflammatory Bowel Disease—a Cinderella story -- Epidemiology and Natural History of Fibrostenosing Inflammatory Bowel Disease -- Genetic influences on the development of fibrosis in inflammatory bowel disease -- Epigenetic regulation of intestinal fibrosis -- Cytokine and Anti-cytokine Agents as Future Therapeutics for Fibrostenosing IBD -- Inflammation-independent mechanisms of intestinal fibrosis: the role of the extracellular matrix -- Fat and Fibrosis -- Environmental factors and their influence on intestinal fibrosis -- Animal models and sources of mesenchymal cells in intestinal fibrosis -- Fibrosis in Ulcerative Colitis -- Histopathology of intestinal fibrosis -- Clinical, Cellular and Serologic Biomarkers of intestinal fibrosis -- The future of intestinal fibrosis imaging -- Imaging in intestinal fibrosis. What is state of the art? -- Medical therapy of stricturing IBD -- Endoscopic therapy of intestinal strictures Çô What is state of the art? -- Resectional surgery for intestinal strictures Çô What is state of the art? -- Management of ileal pouch strictures and anal stricturing disease—A clinical challenge -- The future of surgical therapy of stricturing IBD -- Challenges of translation of anti-fibrotic therapies into clinical practice in IBD -- What distinguishes mechanisms of fistula and stricture formation -- The Pathogenesis of Intraabdominal Adhesions:Similarities and Differences to Luminal Fibrosis -- Anti-fibrotic therapies from other organs—What the gut can learn from the liver, skin, lung and heart.
Format
e-Book
Location
Online
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Imaging of ulcerative colitis

https://libcat.nshealth.ca/en/permalink/provcat33766
Massimo Tonolini, editor. --Milan: Springer , c2014.
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During the past decade, the medical and surgical treatment of ulcerative colitis has undergone dramatic advances, including the widespread use of immunomodulators, biological drugs, and restorative proctocolectomy. In order to correctly balance the risks and benefits of medical therapies and surgical procedures, there is a need for improved diagnosis of colonic disease, acute complications, extraintestinal manifestations, and early and delayed postoperative complications. Cross-sectional imagin…
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Other Authors
Tonolini, Massimo
Responsibility
Massimo Tonolini, editor
Place of Publication
Milan
Publisher
Springer
Date of Publication
c2014
Physical Description
1 online resource (x, 143 pages)
ISBN
9788847054097 (electronic bk.)
9788847054080
Subjects (MeSH)
Colitis, Ulcerative - diagnostic imaging
Colitis, Ulcerative - diagnosis
Radiography
Subjects (LCSH)
Ulcerative colitis - Imaging
Ulcerative colitis - Diagnosis
Colitis, Ulcerative - radiography
Colitis, Ulcerative - diagnosis
Diagnostic Imaging - methods
Diagnostic Radiology
Gastroenterology
Proctology
Abdominal surgery
Abstract
During the past decade, the medical and surgical treatment of ulcerative colitis has undergone dramatic advances, including the widespread use of immunomodulators, biological drugs, and restorative proctocolectomy. In order to correctly balance the risks and benefits of medical therapies and surgical procedures, there is a need for improved diagnosis of colonic disease, acute complications, extraintestinal manifestations, and early and delayed postoperative complications. Cross-sectional imaging techniques are therefore playing an increasing role in the assessment of ulcerative colitis and provide an essential complement to clinical data and endoscopy. This practical, illustrated volume on the role of cross-sectional imaging is aimed at radiologists, gastroenterologists, and surgeons who are engaged or interested in the diagnosis and care of patients with inflammatory bowel disease, particularly ulcerative colitis. After an overview of diagnostic imaging techniques, state-of-the-art assessment of colorectal inflammatory disease with CT colonography using water enema and bowel MRI is discussed, followed by description of the plain radiographic and CT findings in patients with acute exacerbations and surgical complications. Subsequent chapters review the diagnostic findings and role of cross-sectional imaging in the assessment of sclerosing cholangitis (with emphasis on MR cholangiopancreatography), vascular complications (particularly portal and mesenteric thrombosis), colitis-associated colorectal cancer and perianal inflammatory disease. Normal postoperative appearances and early and delayed complications in patients treated with proctocolectomy and ileal pouch-anal anastomosis are also comprehensively reviewed.
Contents
Introduction -- Medical Needs -- Intestinal Ultrasound in Ulcerative Colitis -- Water Enema Multidetector CT Colonography: Technique, Role and Imaging Findings in Ulcerative Colitis -- Magnetic Resonance Imaging of Ulcerative Colitis -- Radiographic and CT Imaging Assessment of Acute Exacerbations and Surgical Complications -- Cross-Sectional Imaging Mimics of Ulcerative Colitis -- Hepato-Bilio-Pancreatic Complications of Ulcerative Colitis -- Vascular Complications of Ulcerative Colitis -- Neoplasms in Ulcerative Colitis -- Musculoskeletal Manifestations of Ulcerative Colitis -- Surgical Perspective on Perianal Complications in Ulcerative Colitis -- Imaging of Perianal Inflammatory Disorders in Ulcerative Colitis -- Ileal Pouch-Anal Anastomosis Surgery: Surgical Techniques -- Imaging of Ileal Pouch Surgery and Related Complications.
Format
e-Book
Location
Online
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