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Ketamine for Treatment-Resistant Depression : The First Decade of Progress

https://libcat.nshealth.ca/en/permalink/provcat40316
Sanjay J. Mathew, Carlos A. Zarate, Jr., editors. --Cham: Springer International Publishing : Imprint: Adis , c2016.
Available Online
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Location
Online
This book brings together an international group of clinicians and researchers from a broad swath of inter-related disciplines to offer the most up-to-date information about clinical and preclinical research into ketamine and second-generation "ketamine-like" fast-acting antidepressants. Currently available antidepressant medications act through monoaminergic systems, are ineffective for many individuals suffering from depression, and are associated with a delayed onset of peak efficacy of seve…
Available Online
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Other Authors
Mathew, Sanjay J
Zarate, Jr., Carlos A
Responsibility
Sanjay J. Mathew, Carlos A. Zarate, Jr., editors
Place of Publication
Cham
Publisher
Springer International Publishing : Imprint: Adis
Date of Publication
c2016
Physical Description
1 online resource (xix, 155 p. : 6 illus., 3 illus. in color)
ISBN
9783319429250
9783319429236 (print ed.)
Subjects (MeSH)
Antidepressive Agents
Depressive Disorder, Major - drug therapy
Depressive Disorder, Treatment-Resistant - drug therapy
Ketamine - therapeutic use
Abstract
This book brings together an international group of clinicians and researchers from a broad swath of inter-related disciplines to offer the most up-to-date information about clinical and preclinical research into ketamine and second-generation "ketamine-like" fast-acting antidepressants. Currently available antidepressant medications act through monoaminergic systems, are ineffective for many individuals suffering from depression, and are associated with a delayed onset of peak efficacy of several months. The unexpected emergence of ketamine, an anesthetic N-methyl-D-aspartate (NMDA) receptor antagonist, as a rapid-acting antidepressant has reinvigorated CNS drug discovery research and catalyzed investigation in patient populations historically ignored in antidepressant drug development programs, particularly treatment-resistant patients and those with suicidality. Recent industry and academic research efforts have coalesced to explore NMDA receptor and glutamatergic molecular targets that lack ketamine's psychotomimetic side effects and abuse liability but retain its rapid onset of efficacy. However, many fundamental questions remain regarding the neurobiological mechanisms underlying ketamine's rapid antidepressant effects and the puzzling persistence of benefits observed in some patients following a single dose. This book examines how insights from these studies are forging new conceptual models of the neurobiology of stress-related affective, anxiety, and addictive disorders and the nature of treatment resistance. It also discusses how ketamine's rapid antidepressant effects provide a scientific platform to facilitate innovation in clinical trial designs pertaining to patient selection, choice of control group, outcome measures, and dose-optimization. This book brings together data and insights from this rapidly expanding and extraordinarily promising field of study. Readers will be able to extract integrated themes and useful insights from the material contained in these diverse chapters and appreciate the paradigm-shifting contributions of ketamine to modern psychiatry and clinical neuroscience research.
Contents
1. The History of Ketamine Use and Its Clinical Indications -- 2. The Basic and Clinical Pharmacology of Ketamine -- 3. Ketamine: Clinical Studies in Treatment- Resistant Depressive Disorders -- 4. Ketamine and Suicide Risk -- 5. Ketamine: Its Safety, Tolerability, and Impact on Neurocognition -- 6. Ketamine’s Mechanisms of Rapid Antidepressant Activity: Evidence from Preclinical Studies -- 7. Ketamine’s Mechanism of Rapid Antidepressant Activity: Evidence Gleaned from Clinical Studies -- 8. Ketamine and Electroconvulsive Therapy -- 9. Emerging Data for Ketamine in Obsessive-Compulsive, Stress-Related, and Substance Use Disorders.
Format
e-Book
Location
Online
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Mood disorders : clinical management and research issues

https://libcat.nshealth.ca/en/permalink/provcat22669
Griez, Eric J. L. --Hoboken, NJ: John Wiley & Sons , 2005.
Call Number
WM 171 G848m 2005
Location
Nova Scotia Hospital
Call Number
WM 171 G848m 2005
Author
Griez, Eric J. L.
Other Authors
Faravelli, Carlo
Place of Publication
Hoboken, NJ
Publisher
John Wiley & Sons
Date of Publication
2005
Physical Description
545 p.
ISBN
0470094265
Subjects (MeSH)
Mood Disorders
Depressive Disorder, Major
Format
Book
Location
Nova Scotia Hospital
Loan Period
3 weeks
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Welcome to the Mood Disorders Clinic

https://libcat.nshealth.ca/en/permalink/chpams36594
Nova Scotia Health Authority. Mood Disorders Clinic. Halifax, NS: Nova Scotia Health Authority , 2019.
Pamphlet Number
2017
Available Online
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The Mood Disorders Clinic provides consultations for individuals with severe mood disorders, such as possible bipolar disorder. This is a specialized service to help diagnose and treat severe mood disorders. Mood disorders are a group of mental illnesses that affect how you feel and think about yourself, other people, and life in general. Two specific types of mood disorders we often see in the clinic are bipolar disorder and major depressive disorder. Topics include: bipolar disorder, symptoms…
Available Online
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Corporate Author
Nova Scotia Health Authority. Mood Disorders Clinic
Place of Publication
Halifax, NS
Publisher
Nova Scotia Health Authority
Date of Publication
2019
Format
Pamphlet
Language
English
Physical Description
1 electronic document (9 p.) : digital, PDF file
Subjects (MeSH)
Mood Disorders - diagnosis
Mood Disorders - therapy
Bipolar Disorder
Depressive Disorder, Major
Subjects (LCSH)
Affective disorders--Diagnosis
Affective disorders--Treatment
Manic-depressive illness
Abstract
The Mood Disorders Clinic provides consultations for individuals with severe mood disorders, such as possible bipolar disorder. This is a specialized service to help diagnose and treat severe mood disorders. Mood disorders are a group of mental illnesses that affect how you feel and think about yourself, other people, and life in general. Two specific types of mood disorders we often see in the clinic are bipolar disorder and major depressive disorder. Topics include: bipolar disorder, symptoms of mania, symptoms of depression, major depressive disorder, causes of mood disorders, how mood disorders are treated, the clinical team, clinical treatment and services, the referral process, your first appointment, and followup care.
Responsibility
Prepared by: Mood Disorders Clinic
Pamphlet Number
2017
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