Access device guidelines : recommendations for nursing practice and education
https://libcat.nshealth.ca/en/permalink/provcat25283
Camp-Sorrell, Dawn.
(3rd ed.)
--Pittsburgh, PA:
Oncology Nursing Society
, 2011.
- Call Number
- WB 354 C186a 2011
- Location
- Dickson Building
- Halifax Infirmary
- Yarmouth Regional Hospital
- Call Number
- WB 354 C186a 2011
- Author
- Camp-Sorrell, Dawn
- Edition
- 3rd ed.
- Place of Publication
- Pittsburgh, PA
- Publisher
- Oncology Nursing Society
- Date of Publication
- 2011
- Physical Description
- 170 p.
- ISBN
- 9781890504960
- Subjects (MeSH)
- Catheterization - nursing - Practice Guideline
- Neoplasms - nursing - Practice Guideline
- Drug Delivery Systems - instrumentation
- Format
- Book
- Location
- Dickson Building
- Halifax Infirmary
- Yarmouth Regional Hospital
- Copies
- 3
- Loan Period
- 3 weeks use
Diagnostic and Prognostic Biomarkers and Therapeutic Targets in Melanoma
https://libcat.nshealth.ca/en/permalink/provcat30996
Michael J. Murphy, editor.
--New York, NY:
Springer
, c2012.
- Available Online
- View e-Book
- Location
- Online
This book describes both the technologies used in the discovery of melanoma biomarkers and the clinical application of these biomarkers for diagnosis and staging of disease, determination of prognosis, treatment planning, monitoring of response to therapy, identification of novel therapeutic targets and drug development. A broad range of biomarkers (DNA/chromosomal, mRNA, microRNA, mitochondrial DNA, epigenetic and protein) is outlined. As therapies for melanoma become increasingly more target …
- Available Online
- View e-Book
- Other Authors
- Murphy, Michael J
- Responsibility
- Michael J. Murphy, editor
- Place of Publication
- New York, NY
- Publisher
- Springer
- Date of Publication
- c2012
- Physical Description
- 1 online resource (xiv, 322 p. : 29 ill., 24 ill. in color)
- Series Title
- Current clinical pathology
- ISBN
- 9781607614333
- Subjects (MeSH)
- Drug Delivery Systems
- Drug Design
- Melanoma - diagnosis
- Melanoma - therapy
- Tumor Markers, Biological
- Subjects (LCSH)
- Dermatology
- Oncology
- Pathology
- Abstract
- This book describes both the technologies used in the discovery of melanoma biomarkers and the clinical application of these biomarkers for diagnosis and staging of disease, determination of prognosis, treatment planning, monitoring of response to therapy, identification of novel therapeutic targets and drug development. A broad range of biomarkers (DNA/chromosomal, mRNA, microRNA, mitochondrial DNA, epigenetic and protein) is outlined. As therapies for melanoma become increasingly more target specific, the identification, validation and use of biomarkers will invariably play a greater role in the management of patients with this disease. Diagnostic and Prognostic Biomarkers and Therapeutic Targets in Melanoma is an essential resource for oncologists, dermatologists, dermatopathologists, general pathologists with an interest in melanoma, and melanoma researchers.
- Contents
- Introduction to Diagnostic and Prognostic Biomarkers and Therapeutic Targets in Melanoma -- Diagnostic and Prognostic Biomarkers in Melanoma: Current State of Play -- Molecular Pathogenesis of Melanoma: Established and Novel Pathways -- Staging of Melanoma -- Clinical and Histopathological Parameters in Melanoma -- Genetic/Epigenetic Biomarkers: Distinction of Melanoma from Other Melanocytic Neoplasms -- mRNA Biomarkers in Melanoma -- Epigenetic Biomarkers in Melanoma -- microRNA Biomarkers in Melanoma -- MicroRNAs as Biomarkers and Therapeutic Targets in Melanoma -- Mitochondrial DNA Biomarkers in Melanoma -- Tissue-Based Protein Biomarkers in Melanoma: Immunohistochemistry: (A) Diagnosis -- Tissue-Based Protein Biomarkers in Melanoma: Immunohistochemistry: (B) Prognostication -- Tissue-Based Protein Biomarkers in Melanoma: Mass Spectrometry-Based Strategies -- Serological Biomarkers in Melanoma -- Molecular Markers of Lymph Node Disease in Melanoma -- Melanoma Cell Propagation: Cancer Stem Cell, Clonal Evolution and Interconversion Models of Tumorigenicity -- Surgical Management of Melanoma: Concept of Field Cancerization and Molecular Evaluation of Tissue Margins -- Chemotherapy for Melanoma -- Molecular-Targeted Therapy for Melanoma -- Anti-Angiogenesis Therapy for Melanoma -- Immunological Biomarkers and Immunotherapy for Melanoma -- Diagnostic and Prognostic Biomarkers and Therapeutic Targets in Melanoma: An Overview.
- Format
- e-Book
- Location
- Online
Drug-Coated Balloons : Applications in Interventional Cardiology
https://libcat.nshealth.ca/en/permalink/provcat44613
Bernardo Cortese, editor.
--Cham:
Springer
, c2019.
- Available Online
- View e-Book
- Location
- Online
This book provides a comprehensive, up-to-date summary of drug-coated balloon (DCB) technology and the role of DCBs in the treatment of coronary and peripheral arterial disease. In addition to clear explanation of how DCBs work, readers will find an enlightening analysis of the mistakes and successes of the past decade and the emergence of the latest delivery systems, which combine a more deliverable device with much improved drug delivery to the vessel wall. The full range of current applicati…
- Available Online
- View e-Book
- Other Authors
- Cortese, Bernardo
- Responsibility
- Bernardo Cortese, editor
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2019
- Physical Description
- 1 online resource (viii, 234 p.) : 88 illus., 56 illus. in color
- ISBN
- 9783319926001
- 9783319925998 (Print ed.)
- 9783319926018 (Print ed.)
- Specialty
- Cardiovascular Surgical Procedures
- Pharmacy
- Abstract
- This book provides a comprehensive, up-to-date summary of drug-coated balloon (DCB) technology and the role of DCBs in the treatment of coronary and peripheral arterial disease. In addition to clear explanation of how DCBs work, readers will find an enlightening analysis of the mistakes and successes of the past decade and the emergence of the latest delivery systems, which combine a more deliverable device with much improved drug delivery to the vessel wall. The full range of current applications of DCBs are reviewed in detail, drawing on the latest scientific evidence. Due attention is paid to newer devices, with provision of technical insights and documentation of the available clinical data. Ongoing research projects, remaining technical challenges, likely future directions, and reimbursement issues are also carefully considered. This book will be a useful tool for any interventional cardiologist, interventional radiologist, or vascular surgeon who wishes to acquire a deep knowledge of this technology and its application in both coronary and peripheral interventions.
- Contents
- 1. From Drug-Eluting Balloon to Drug-Coated Balloon … to Eradication of Intracoronary Metal, a New Ending Story -- 2. History of Drug-Coated Balloons -- 3. Previous Mistakes with DCB Technology, and How to Prevent Them in the Future -- 4. Local Drug Delivery to Prevent Restenosis of the Coronary and Peripheral Arteries -- 5. Technical Insights on Drug-Coated Balloons -- 6. Technical Insights on Drug-Coated Balloons II -- 7. Design Parameters for Drug-Coated Balloons II -- 8. Potential Clinical Advantages of Drug-Coated Balloon in Specific Clinical Settings -- 9. The Use of Drug-Coated Balloons for Patients with In-Stent Restenosis -- 10. Drug-Coated Balloons in Native Coronary Artery Disease -- 11. Drug-Eluting Balloons in Coronary Bifurcation Lesions -- 12. Dissection Management with Drug-Coated Balloons -- 13. The Role of Drug-Coated Balloons on Late Lumen Enlargement -- 14. Sirolimus-Coated Balloon: Insights on a New Technology for Coronary Use -- 15. Drug-Coated Balloon in Superficial Femoral Artery In-Stent Restenosis -- 16. Drug-Coated Balloons for Native Femoro-popliteal Disease -- 17. The Role of Drug-Coated Balloon for the Treatment of Native Below-the-Knee Arteries -- 18. Drug-Coated Balloons: Lessons from the Real World -- 19. Stent Use After Drug-Coated Balloons -- 20. Drug-Coated Balloon and Antithrombotic Therapy -- 21. Cost/Effectiveness and Reimbursement Policies with Drug-Coated Balloons in Europe -- 22. Current Technical Challenges and the Future of Drug-Coated Balloons.
- Format
- e-Book
- Location
- Online
Drug delivery systems : advanced technologies potentially applicable in personalised treatment
https://libcat.nshealth.ca/en/permalink/provcat32644
Jorge Coelho, editor.
--Dordrecht:
Springer
, c2013.
- Available Online
- View e-Book
- Location
- Online
This book is part of a series dedicated to recent advances on preventive, predictive and personalised medicine (APPPM). It focuses on the theme of 'Drug delivery systems: advanced technologies potentially applicable in personalised treatments'. The critical topics involving the development and preparation of effective drug delivery systems, such as: polymers available, self-assembly, nanotechnology, pharmaceutical formulations, three dimensional structures, molecular modeling, tailor-made solut…
- Available Online
- View e-Book
- Other Authors
- Coelho, Jorge
- Responsibility
- Jorge Coelho, editor
- Place of Publication
- Dordrecht
- Publisher
- Springer
- Date of Publication
- c2013
- Physical Description
- 1 online resource (xvii, 421 p. : 124 ill., 67 ill. in color)
- ISBN
- 9789400760103
- Subjects (LCSH)
- Medicine
- Polymers
- Biochemistry
- Diabetes
- Abstract
- This book is part of a series dedicated to recent advances on preventive, predictive and personalised medicine (APPPM). It focuses on the theme of 'Drug delivery systems: advanced technologies potentially applicable in personalised treatments'. The critical topics involving the development and preparation of effective drug delivery systems, such as: polymers available, self-assembly, nanotechnology, pharmaceutical formulations, three dimensional structures, molecular modeling, tailor-made solutions and technological tendencies, are carefully discussed. The understanding of these areas constitutes a paramount route to establish personalised and effective solutions for specific diseases and individuals.
- Contents
- Polymers in Drug Delivery: Concepts, Developments and Potential -- Amphiphilic Molecules in Drug Delivery Systems -- Sizing nanoparticles in liquids: an overview of methods -- Nanoparticles for oral delivery of insulin -- Bioartificial pancreas: in the road to clinical application -- Cationic liposome-based systems for nucleic acid delivery: from the formulation development to therapeutic applications -- Biomaterial-based vectors for targeted delivery of nucleic acids to the nervous system -- Three-dimensional (3D) scaffolds as drug delivery devices for Tissue engineering applications -- The Warburg Effect is a Guide to Multipurpose Cancer Therapy Including Trace Element Delivery -- In silico research in drug delivery systems -- The Importance of Controlled/Living Radical Polymerization Techniques in the Design of Tailor Made Nanoparticles for DSS -- Index.
- Format
- e-Book
- Location
- Online
Experimental Investigations into Sarcomas : Therapy Using Ferromagnetically Induced Cytostatics
https://libcat.nshealth.ca/en/permalink/provcat43149
Manfred Georg Krukemeyer.
--Wiesbaden:
Springer
, c2018.
- Available Online
- View e-Book
- Location
- Online
Manfred Georg Krukemeyer first describes magnetic drug targeting, by which is meant the focused application of drugs, e.g. the introduction of a cytostatic, and which is aimed at optimising its locally therapeutic effect. The author thus achieves a high concentration of cytostatic at the site of the tumour. The particles have to be large enough to be attracted by a magnetic field and so find their way into the tumour, where they release their active ingredient. The aim of the hypothesis formed …
- Available Online
- View e-Book
- Author
- Krukemeyer, Manfred Georg
- Responsibility
- Manfred Georg Krukemeyer
- Place of Publication
- Wiesbaden
- Publisher
- Springer
- Date of Publication
- c2018
- Physical Description
- 1 online resource (xii, 122 p.) : 39 illus., 21 illus. in color
- ISBN
- 9783658205911
- 9783658205904 (print ed.)
- 9783658205928 (print ed.)
- Specialty
- Medical Oncology
- Abstract
- Manfred Georg Krukemeyer first describes magnetic drug targeting, by which is meant the focused application of drugs, e.g. the introduction of a cytostatic, and which is aimed at optimising its locally therapeutic effect. The author thus achieves a high concentration of cytostatic at the site of the tumour. The particles have to be large enough to be attracted by a magnetic field and so find their way into the tumour, where they release their active ingredient. The aim of the hypothesis formed by one of the author's study groups was to show in a scientific experiment that in this case cytostatics coupled with iron particles [Fe3O4] can be introduced into a tumour. The focused introduction of drugs—magnetic drug targeting—results in faster arrival of the active ingredient at the target site together with a reduced quantity of active substances. For this reason magnetic drug targeting is also interesting from an economic point of view. Contents: Sarcomas and their Pathology; Magnetic Drug Targeting; Animal Testing and Patient Examination; Tumour Therapy in Humans; Target groups; Researchers, teachers and students in surgical and oncology departments Doctors working in the fields of surgery and oncology. About the author: Dr. Manfred Georg Krukemeyer is a specialist surgeon currently holding a senior position at a large German hospital enterprise.
- Format
- e-Book
- Location
- Online
Handbook of drug administration via enteral feeding tubes
https://libcat.nshealth.ca/en/permalink/provcat25118
White, Rebecca.
British Pharmaceutical Nutrition Group.
(2nd ed.)
--London, England:
Pharmaceutical Press
, 2011.
- Call Number
- WB 354 W587h 2011
- Location
- Halifax Infirmary
- Call Number
- WB 354 W587h 2011
- Author
- White, Rebecca
- Corporate Author
- British Pharmaceutical Nutrition Group
- Other Authors
- Bradnam, Vicky
- Edition
- 2nd ed.
- Place of Publication
- London, England
- Publisher
- Pharmaceutical Press
- Date of Publication
- 2011
- Physical Description
- 614 p.
- ISBN
- 9780853699286
- Subjects (MeSH)
- Enteral Nutrition - methods - Handbooks
- Drug Delivery Systems - Handbooks
- Dosage Forms - Handbooks
- Drug Therapy - Handbooks
- Format
- Book
- Location
- Halifax Infirmary
- Loan Period
- 3 weeks
Macromolecular Anticancer Therapeutics
https://libcat.nshealth.ca/en/permalink/provcat29332
edited by L. Harivardhan Reddy, Patrick Couvreur.
--New York, NY:
Springer-Verlag
, c2010.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Author
- Reddy, L. Harivardhan
- Other Authors
- Couvreur, Patrick
- Responsibility
- edited by L. Harivardhan Reddy, Patrick Couvreur
- Place of Publication
- New York, NY
- Publisher
- Springer-Verlag
- Date of Publication
- c2010
- Series Title
- Macromolecular Anticancer Therapeutics
- ISBN
- 9781441905079
- Subjects (MeSH)
- Antineoplastic Agents - administration & dosage
- Drug Delivery Systems
- Macromolecular Substances
- Neoplasms - drug therapy
- Subjects (LCSH)
- Oncology
- Format
- e-Book
- Location
- Online
New Trends in the Molecular and Biological Basis for Clinical Oncology
https://libcat.nshealth.ca/en/permalink/provcat28635
edited by Tetsuhiko Tachikawa, Kiyoshi Nose, Tohru Ohmori, Mitsuru Adachi.
--Tokyo:
Springer Japan
, c2009.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Author
- Tachikawa, Tetsuhiko
- Other Authors
- Nose, Kiyoshi
- Ohmori, Tohru
- Adachi, Mitsuru
- Responsibility
- edited by Tetsuhiko Tachikawa, Kiyoshi Nose, Tohru Ohmori, Mitsuru Adachi
- Place of Publication
- Tokyo
- Publisher
- Springer Japan
- Date of Publication
- c2009
- ISBN
- 9784431886631
- Subjects (MeSH)
- Antineoplastic Agents - therapeutic use
- Drug Delivery Systems
- Neoplasms - drug therapy
- Subjects (LCSH)
- Oncology
- Format
- e-Book
- Location
- Online
Ocular Transporters In Ophthalmic Diseases And Drug Delivery : Ophthalmology Research
https://libcat.nshealth.ca/en/permalink/provcat29034
edited by Joyce Tombran-Tink, Colin J. Barnstable.
--Totowa, NJ:
Humana Press
, c2008.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Author
- Tombran-Tink, Joyce
- Other Authors
- Barnstable, Colin J
- Responsibility
- edited by Joyce Tombran-Tink, Colin J. Barnstable
- Place of Publication
- Totowa, NJ
- Publisher
- Humana Press
- Date of Publication
- c2008
- Series Title
- Ophthalmology research
- ISBN
- 9781597453752
- Subjects (MeSH)
- Drug Delivery Systems
- Eye Diseases - drug therapy
- Eye Diseases - physiopathology
- Ion Transport
- Membrane Transport Proteins
- Ocular Physiological Phenomena
- Subjects (LCSH)
- Ophthalmology
- Cytology
- Format
- e-Book
- Location
- Online
Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement : Drug Manipulation Strategies and Vehicle Effects
https://libcat.nshealth.ca/en/permalink/provcat39433
Nina Dragicevic, Howard I. Maibach, editors.
--Berlin, Heidelberg:
Springer
, c2015.
- Available Online
- View e-Book
- Location
- Online
This truly comprehensive reference, in a mini-series format with five volumes, offers a detailed description of both well-known and recently introduced methods for percutaneous penetration enhancement. The first three volumes are devoted to the broad range of chemical methods used to enhance the skin delivery of drugs, including the vast variety of chemical penetration enhancers, drug and vehicle manipulation strategies, nanocarriers, and many others. The fourth volume discusses the diverse phy…
- Available Online
- View e-Book
- Other Authors
- Dragicevic, Nina
- Maibach, Howard I
- Responsibility
- Nina Dragicevic, Howard I. Maibach, editors
- Place of Publication
- Berlin, Heidelberg
- Publisher
- Springer
- Date of Publication
- c2015
- Physical Description
- 1 online resource (xvi, 341 p. : 118 illus., 38 illus. in color)
- Series Title
- Percutaneous penetration enhancers
- ISBN
- 9783662450130
- 9783662450123 (print ed.)
- Subjects (MeSH)
- Administration, Cutaneous
- Drug Delivery Systems
- Skin Absorption - drug effects
- Skin - drug effects
- Abstract
- This truly comprehensive reference, in a mini-series format with five volumes, offers a detailed description of both well-known and recently introduced methods for percutaneous penetration enhancement. The first three volumes are devoted to the broad range of chemical methods used to enhance the skin delivery of drugs, including the vast variety of chemical penetration enhancers, drug and vehicle manipulation strategies, nanocarriers, and many others. The fourth volume discusses the diverse physical methods used in penetration enhancement, such as sonophoresis, iontophoresis, electroporation, microporation, laser ablation, and microneedles. Determination of drug penetration is covered in the final volume, with a focus especially on mathematics in skin permeation and modern analytical techniques adapted to assess and measure penetration. This edition of Percutaneous Penetration Enhancers will be an invaluable resource for researchers, pharmaceutical scientists, practitioners, and also students.
- Contents
- [publisher supplied] THE SKIN -- The Skin Structure And Penetration Pathways Through The Skin -- The Increasing Importance Of The Follicular Route In Dermal And Transdermal Drug Delivery -- The Importance Of SC Lipid Organization For Skin Barrier Function -- Nanostructure Of The Epidermal Extracellular Space Investigated By Cryo-Electron Microscopy And Tomography -- The Correlation Between Transepidermal Water Loss And Percutaneous Drug Absorption -- Influence Of Excipients On The Stratum Corneum Lipids And Epidermal Tight Junctions -- PENETRATION ENHANCEMENT TECHNIQUES IN SKIN DELIVERY -- Classification Of Penetration Enhancement Techniques -- DRUG MANIPULATION STRATEGIES IN PENETRATION ENHANCEMENT -- Selection Of A Proper Prodrug For Penetration Enhancement -- Supersaturated Solutions For Penetration Enhancement -- Eutectic Systems For Penetration Enhancement -- INFLUENCE OF VEHICLE EFFECTS IN PENETRATION ENHANCEMENT -- Dermal and Transdermal Formulations -- EMULSIONS (AS SKIN DELIVERY SYSTEMS) AS VEHICLES FOR SKIN DELIVERY -- GELS AS VEHICLES FOR SKIN DELIVERY.
- Format
- e-Book
- Location
- Online
Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement : Modification of the Stratum Corneum
https://libcat.nshealth.ca/en/permalink/provcat39462
Nina Dragicevic, Howard I. Maibach, editors.
(1st ed.)
--Berlin, Heidelberg:
Springer
, c2015.
- Available Online
- View e-Book
- Location
- Online
Percutaneous Penetration Enhancers in a mini-series format comprising five volumes, represents the most comprehensive reference on enhancement methods--both well established and recently introduced--in the field of dermal/transdermal drug delivery. In detail the broad range of both chemical and physical methods used to enhance the skin delivery of drugs is described. All aspects of drug delivery and measurement of penetration are covered and the latest findings are provided on skin structure an…
- Available Online
- View e-Book
- Other Authors
- Dragicevic, Nina
- Maibach, Howard I
- Responsibility
- Nina Dragicevic, Howard I. Maibach, editors
- Edition
- 1st ed.
- Place of Publication
- Berlin, Heidelberg
- Publisher
- Springer
- Date of Publication
- c2015
- Physical Description
- 1 online resource (xvi, 411 p. : 123 illus., 56 illus. in color)
- Series Title
- Percutaneous penetration enhancers
- ISBN
- 9783662470398
- 9783662470381 (print ed.)
- Subjects (MeSH)
- Administration, Cutaneous
- Drug Delivery Systems
- Skin Absorption - drug effects
- Skin - drug effects
- Abstract
- Percutaneous Penetration Enhancers in a mini-series format comprising five volumes, represents the most comprehensive reference on enhancement methods--both well established and recently introduced--in the field of dermal/transdermal drug delivery. In detail the broad range of both chemical and physical methods used to enhance the skin delivery of drugs is described. All aspects of drug delivery and measurement of penetration are covered and the latest findings are provided on skin structure and function, mathematics in skin permeation and modern analytical techniques adapted to assess and measure penetration. In offering a detailed description of the methods currently in use for penetration enhancement, this book will be of value for researchers, pharmaceutical scientists, practitioners and also students.
- Contents
- [publisher supplied] THE ROLE OF SKIN HYDRATION IN PENETRATION ENHANCEMENT -- CHEMICAL PENETRATION ENHANCERS IN PENETRATION ENHANCEMENT -- Classification -- Mechanism -- Structure-Activity Relationship -- The Microenvironment Of The Enhancer Site Of Action -- Sulphoxides And Similar Chemicals -- Iminosulfuranes -- Azone And Azone Analogues -- Fatty Acids, Fatty Acid Esters And Fatty Alcohols -- Alcohols And Glycols -- Terpenes And Essential Oils -- Transcutol Surfactants -- Nonionic Surfactants -- Natural Surfactants Of The Alkylpolyglucoside Type -- Sucrose Esters -- Pyrrolidones -- Chitosan -- Urea And Its Derivatives -- Transcarbams -- Amines And Amides -- Peptides -- Synergistic Effects -- CHEMICAL METHODS FOR TRANSDERMAL DELIVERY OF PEPTIDES AND PROTEINS -- Ultradeformable Vesicles -- Biphasic Vesicles For Transdermal Delivery Of Proteins -- CHEMICAL METHODS IN CUTANEOUS VACCINATION -- Vesicular Carriers In Transcutaneous DNA Vaccination -- Nanoparticles And Microparticles For Transcutaneous DNA Vaccination -- Chitosan-Nanoparticles In Gene Delivery.
- Format
- e-Book
- Location
- Online
Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement : Nanocarriers
https://libcat.nshealth.ca/en/permalink/provcat40362
Nina Dragicevic, Howard I. Maibach, editors.
(1st ed.)
--Berlin, Heidelberg:
Springer
, c2016.
- Available Online
- View e-Book
- Location
- Online
Percutaneous Penetration Enhancers in a mini-series format comprising five volumes, represents the most comprehensive reference on enhancement methods--both well established and recently introduced--in the field of dermal/transdermal drug delivery. In detail the broad range of both chemical and physical methods used to enhance the skin delivery of drugs is described. All aspects of drug delivery and measurement of penetration are covered and the latest findings are provided on skin structure an…
- Available Online
- View e-Book
- Other Authors
- Dragicevic, Nina
- Maibach, Howard I
- Responsibility
- Nina Dragicevic, Howard I. Maibach, editors
- Edition
- 1st ed.
- Place of Publication
- Berlin, Heidelberg
- Publisher
- Springer
- Date of Publication
- c2016
- Physical Description
- 1 online resource (xvi, 384 p. : 132 illus., 70 illus. in color)
- Series Title
- Percutaneous penetration enhancers
- ISBN
- 9783662478622
- 9783662478615 (print ed.)
- Subjects (MeSH)
- Administration, Cutaneous
- Drug Delivery Systems
- Nanostructures
- Skin Absorption - drug effects
- Abstract
- Percutaneous Penetration Enhancers in a mini-series format comprising five volumes, represents the most comprehensive reference on enhancement methods--both well established and recently introduced--in the field of dermal/transdermal drug delivery. In detail the broad range of both chemical and physical methods used to enhance the skin delivery of drugs is described. All aspects of drug delivery and measurement of penetration are covered and the latest findings are provided on skin structure and function, mathematics in skin permeation and modern analytical techniques adapted to assess and measure penetration. In offering a detailed description of the methods currently in use for penetration enhancement, this book will be of value for researchers, pharmaceutical scientists, practitioners and also students.
- Contents
- [publisher supplied] NANOCARRIERS IN PENETRATION ENHANCEMENT -- Role Of Nanotechnology In Skin Delivery Of Drugs -- LIPID-BASED VESICLES -- Liposomes As Drug Delivery Systems In Dermal/Transdermal Drug Delivery (From The Beginning) -- Transfersomes For Enhanced Skin Permeation Of Drugs -- Mechanism Of Penetration Enhancement Of Ultra deformable Vesicles -- Enhanced Skin Permeation Using Ethosomes -- Invasomes-Vesicles For Enhanced Skin Delivery Of Drugs -- Penetration-Enhancer-Containing Vesicles For Cutaneous Drug Delivery -- Stratum Corneum Lipid Liposomes -- Vesosomes -- Surface-Charged Vesicles For Penetration Enhancement -- SURFACTANT-BASED VESICLES -- Niosomes And Pro-Niosomes For Enhanced Skin Delivery -- Novasomes For Enhanced Skin Delivery -- LIPID-BASED ICULATE CARRIERS (OR ICLES) -- Solid Lipid Nanoicles, Nano structured Lipid Carriers And Lipid Nano capsules For Topical Delivery -- POLYMER-BASED NANOCARRIERS (ICULATE CARRIERS) IN PENETRATION ENHANCEMENT -- Polymeric Nano (And Micro-) Particles As Carriers For Enhanced Skin Penetration (General) -- Polymeric Nanocapsules For Cutaneous Application -- Polymeric Micelles In Dermal/Transdermal Drug Delivery -- Dendrimers In Enhancing Skin Penetration -- Dendritic Core-Multishell (CMS) Nanotransporters For Skin Delivery -- NANOCRYSTALS IN PENETRATION ENHANCEMENT -- Nanocrystals For Enhanced Skin Delivery Of Drugs.
- Format
- e-Book
- Location
- Online
Percutaneous Penetration Enhancers Drug Penetration Into/Through the Skin : Methodology and General Considerations
https://libcat.nshealth.ca/en/permalink/provcat41892
Nina Dragicevic, Howard I. Maibach, editors.
--Berlin, Heidelberg:
Springer
, 2017.
- Available Online
- View e-Book
- Location
- Online
Percutaneous Penetration Enhancers in a mini-series format comprising five volumes, represents the most comprehensive reference on enhancement methods – both well established and recently introduced – in the field of dermal/transdermal drug delivery. In detail the broad range of both chemical and physical methods used to enhance the skin delivery of drugs is described. All aspects of drug delivery and measurement of penetration are covered, and the latest findings are provided on skin structure…
- Available Online
- View e-Book
- Other Authors
- Dragicevic, Nina
- I. Maibach, Howard
- Responsibility
- Nina Dragicevic, Howard I. Maibach, editors
- Place of Publication
- Berlin, Heidelberg
- Publisher
- Springer
- Date of Publication
- 2017
- Physical Description
- 1 online resource (xvi, 414 pages) : 126 illus., 50 illus. in color
- ISBN
- 9783662532706
- 9783662532683 (print ed.)
- Subjects (MeSH)
- Administration, Cutaneous
- Drug Delivery Systems
- Pharmaceutical Preparations - administration & dosage
- Skin Absorption - drug effects
- Abstract
- Percutaneous Penetration Enhancers in a mini-series format comprising five volumes, represents the most comprehensive reference on enhancement methods – both well established and recently introduced – in the field of dermal/transdermal drug delivery. In detail the broad range of both chemical and physical methods used to enhance the skin delivery of drugs is described. All aspects of drug delivery and measurement of penetration are covered, and the latest findings are provided on skin structure and function, mathematics in skin permeation, and modern analytical techniques adapted to assess and measure penetration. In offering a detailed description of the methods currently in use for penetration enhancement, this book will be of value for researchers, pharmaceutical scientists, practitioners, students and dermatological scientists or dermatologists .
- Contents
- Part I: Factors Influencing Percutaneous Drug Penetration -- 1. Basic Mathematics in Skin Absorption -- 2. Occlusive Versus Nonocclusive Application in Transdermal Drug Delivery -- 3. Finite and Infinite Dosing -- 4. Non-formulation Parameters That Affect Penetrant-SkinVehicle Interactions and Percutaneous Absorption -- 5. The Influence of Emollients on Dermal and Transdermal Drug Delivery -- 6. The Effects of Vehicle Mixtures on Transdermal Absorption: Thermodynamics, Mechanisms, Assessment, and Prediction -- 7. Mechanistic Studies of Permeation Enhancers -- 8. High Throughput Screening of Transdermal Penetration Enhancers: Opportunities, Methods, and Applications -- Part II: Methods for Measuring the Percutaneous Drug Penetration -- 9. Models, Methods, and Measurements in Transdermal Drug Delivery -- 10. Human Native and Reconstructed Skin Preparations for In Vitro Penetration and Permeation Studies -- 11. Stripping Procedures for Penetration Measurements of Topically Applied Substances -- 12. Application of EPR-spin Probes to Evaluate Penetration Efficiency, Storage Capacity of Nanotransporters, and Drug Release -- 13. Confocal Raman Spectroscopy as a Tool to Investigate the Action of Penetration Enhancers Inside the Skin -- 14. ATR-FTIR Spectroscopy and the Skin Barrier: Evaluation of Penetration-Enhancement Effects -- 15. Confocal Microscopy for Visualization of Skin Penetration -- 16. Clinical Cutaneous Drug Delivery Assessment Using Single and Multiphoton Microscopy -- 17. Corneoxenometry: A Bioassay Exploring Skin Barrier Breaching -- Part III: The Retardation of Percutaneous Drug Penetration -- 18. Retardation Strategies for Sunscreen Agents -- 19. Retardation of Dermal Release by Film Forming Emulsions -- Part IV: Current Status of Dermal and Transdermal Drug Delivery -- 20. Penetration-Enhancement Strategies for Dermal and Transdermal Drug Delivery: An Overview of Recent Research Studies and Patents -- 21. Perspectives on Dermal Delivery of Macromolecular Drugs -- 22. Active Enhancement Methods in Transdermal Drug Delivery: Current Status and Future Perspectives -- Part V: Safety Issues and Ethics in Studies on Dermal and Transdermal Delivery -- 23. Efficacy, Safety and Targets in Topical and Transdermal Active and Excipient Delivery -- 24. Ethical Considerations in Research Involving Dermal and Transdermal Drug Delivery.
- Format
- e-Book
- Location
- Online
Percutaneous Penetration Enhancers Physical Methods in Penetration Enhancement
https://libcat.nshealth.ca/en/permalink/provcat41893
Nina Dragicevic, Howard I. Maibach, editors.
--Berlin, Heidelberg:
Springer
, 2017.
- Available Online
- View e-Book
- Location
- Online
Percutaneous Penetration Enhancers in a mini-series format comprising five volumes, represents the most comprehensive reference on enhancement methods – both well established and recently introduced – in the field of dermal/transdermal drug delivery. In detail the broad range of both chemical and physical methods used to enhance the skin delivery of drugs is described. All aspects of drug delivery and measurement of penetration are covered, and the latest findings are provided on skin structure…
- Available Online
- View e-Book
- Other Authors
- Dragicevic, Nina
- I. Maibach, Howard
- Responsibility
- Nina Dragicevic, Howard I. Maibach, editors
- Place of Publication
- Berlin, Heidelberg
- Publisher
- Springer
- Date of Publication
- 2017
- Physical Description
- 1 online resource (xvii, 508 pages) : 126 illus., 47 illus. in color
- ISBN
- 9783662532737
- 9783662532713 (print ed.)
- Subjects (MeSH)
- Administration, Cutaneous
- Drug Delivery Systems
- Pharmaceutical Preparations - administration & dosage
- Skin Absorption - drug effects
- Abstract
- Percutaneous Penetration Enhancers in a mini-series format comprising five volumes, represents the most comprehensive reference on enhancement methods – both well established and recently introduced – in the field of dermal/transdermal drug delivery. In detail the broad range of both chemical and physical methods used to enhance the skin delivery of drugs is described. All aspects of drug delivery and measurement of penetration are covered, and the latest findings are provided on skin structure and function, mathematics in skin permeation, and modern analytical techniques adapted to assess and measure penetration. In offering a detailed description of the methods currently in use for penetration enhancement, this book will be of value for researchers, pharmaceutical scientists, practitioners, and also students.
- Contents
- Part I: Sonophoresis in Penetration Enhancement -- Part II: Iontophoresis in Penetration Enhancement -- Part III: Electroporation in Penetration Enhancement -- Part IV: Novel Electrochemical Devices -- Part V: Different Waves in Penetration Enhancement -- Part VI: The Use of Magnetic Fields in Penetration Enhancement -- Part VII: Moxibustion in Penetration Enhancement -- Part VIII: Needle-Free Jet Injections -- Part IX: Removing or Bypassing the Stratum Corneum -- Part X: Novel Natural Methods for Bypassing the Stratum Corneum -- Part XI: Combination of Different Physical Methods in Penetration Enhancement -- Part XII: Combination of Passive (Chemical) and Active (Physical) Methods in Penetration Enhancement -- Part XIII: Physical Methods for Transdermal Delivery of Peptides and Proteins -- Part XIV: Physical Methods in Intradermal Vaccination and Gene Delivery.
- Format
- e-Book
- Location
- Online
Sterile processing for pharmacy technicians
https://libcat.nshealth.ca/en/permalink/provcat26031
Karen Davis.
--St. Louis, MO:
Elsevier Saunders
, c2014.
- Call Number
- QV 778 D262s 2014
- Location
- Dickson Building
- Halifax Infirmary
- Call Number
- QV 778 D262s 2014
- Author
- Davis, Karen
- Responsibility
- Karen Davis
- Place of Publication
- St. Louis, MO
- Publisher
- Elsevier Saunders
- Date of Publication
- c2014
- Physical Description
- 147 p.
- ISBN
- 9781455711277
- Subjects (MeSH)
- Dosage Forms
- Drug Delivery Systems
- Drug Compounding - methods
- Sterilization
- Pharmacists' Aides
- Technology, Pharmaceutical
- Format
- Book
- Location
- Dickson Building
- Halifax Infirmary
- Loan Period
- 3 weeks
Targeted Cancer Therapy
https://libcat.nshealth.ca/en/permalink/provcat29554
edited by Razelle Kurzrock, Maurie Markman.
--Totowa, NJ:
Humana Press
, c2008.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Author
- Kurzrock, Razelle
- Other Authors
- Markman, Maurie
- Responsibility
- edited by Razelle Kurzrock, Maurie Markman
- Place of Publication
- Totowa, NJ
- Publisher
- Humana Press
- Date of Publication
- c2008
- Series Title
- Current clinical oncology
- ISBN
- 9781603274241
- Subjects (MeSH)
- Antineoplastic Agents - therapeutic use
- Drug Delivery Systems
- Drug Design
- Neoplasms - drug therapy
- Subjects (LCSH)
- Oncology
- Format
- e-Book
- Location
- Online
Targeted Interference with Signal Transduction Events
https://libcat.nshealth.ca/en/permalink/provcat40590
B. Groner (ed.).
--Berlin, Heidelberg:
Springer
, c2007.
- Available Online
- View e-Book
- Location
- Online
Sequencing of the human genome and insights into signaling pathways have contributed to the understanding of cancer etiology and the development of new, improved cancer drugs. DNA mutations of a limited set of genes are responsible for the multiple stages of tumorigenesis and metastasis. Matching of therapeutic intervention with insights into the underlying molecular disease mechanism has led to the development of drugs such as Herceptin and Glivec. The deregulation of pathways due to mutated c…
- Available Online
- View e-Book
- Other Authors
- Groner, B. (Bernd)
- Responsibility
- B. Groner (ed.)
- Place of Publication
- Berlin, Heidelberg
- Publisher
- Springer
- Date of Publication
- c2007
- Physical Description
- 1 online resource (ix, 188 p.)
- Series Vol.
- 172
- Series Title
- Resent results in cancer research
- ISBN
- 9783540312093
- 9783540312086 (print ed.)
- ISSN
- 0080-0015
- Subjects (MeSH)
- Cell Communication - physiology
- Drug Delivery Systems
- Neoplasms - drug therapy
- Neoplasms - physiopathology
- Signal transduction - physiology
- Abstract
- Sequencing of the human genome and insights into signaling pathways have contributed to the understanding of cancer etiology and the development of new, improved cancer drugs. DNA mutations of a limited set of genes are responsible for the multiple stages of tumorigenesis and metastasis. Matching of therapeutic intervention with insights into the underlying molecular disease mechanism has led to the development of drugs such as Herceptin and Glivec. The deregulation of pathways due to mutated cancer genes provides the conceptual basis for future progress. Will it be possible to extrapolate this principle and derive more efficient drugs targeting cancer pathway components? Potential drug targets have been identified, but our ability to predict the consequences of inhibition of such components is still limited. The state of development of tomorrow's cancer drugs, directed against growth factors, growth factor receptors and intracellular signaling molecules with kinase activities, is described in this book.
- Contents
- Introduction: The Rationale for the Development of Targeted Drugs in Cancer Therapy -- Identifying Critical Signaling Molecules for the Treatment of Cancer -- Tyrosine Kinase Inhibitors and Cancer Therapy -- Targeting ERBB Receptors in Cancer -- Inhibition of the IGF-I Receptor for Treatment of Cancer. Kinase Inhibitors and Monoclonal Antibodies as Alternative Approaches -- Inhibition of the TGF-ß Signaling Pathway in Tumor Cells -- The Mammalian Target of Rapamycin Kinase and Tumor Growth Inhibition -- The Ras Signalling Pathway as a Target in Cancer Therapy -- The Mitogen-Activated Protein Kinase Pathway for Molecular-Targeted Cancer Treatment -- Clinical Relevance of Targeted Interference with Src-Mediated Signal Transduction Events.
- Format
- e-Book
- Location
- Online
Targeted Therapies in Cancer
https://libcat.nshealth.ca/en/permalink/provcat28538
edited by Manfred Dietel.
--Berlin, Heidelberg:
Springer-Verlag
, c2007.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Author
- Dietel, Manfred
- Responsibility
- edited by Manfred Dietel
- Place of Publication
- Berlin, Heidelberg
- Publisher
- Springer-Verlag
- Date of Publication
- c2007
- Series Vol.
- 176
- Series Title
- Recent results in cancer research
- ISBN
- 9783540460916
- Subjects (MeSH)
- Antineoplastic Agents - therapeutic use
- Drug Delivery Systems
- Neoplasms - drug therapy
- Subjects (LCSH)
- Oncology
- Format
- e-Book
- Location
- Online
Targeting the IL-17 Pathway in Inflammatory Disorders
https://libcat.nshealth.ca/en/permalink/provcat41287
Cong-Qiu Chu.
--Cham:
Adis
, 2017.
- Available Online
- View e-Book
- Location
- Online
This book provides an overview of the discovery and structure of IL-17, including its pathogenesis and role in chronic inflammation and autoimmunity. To capture the latest developments and product approvals the book also discusses the therapeutic advances and looks at emerging therapies targeting the IL-17 pathway. IL-17 is a pro-inflammatory cytokine that has a key role in inflammation, autoimmunity, and host defense in a number of inflammatory disorders such as rheumatoid arthritis, psoriatic…
- Available Online
- View e-Book
- Author
- Chu, Cong-Qiu
- Responsibility
- Cong-Qiu Chu
- Place of Publication
- Cham
- Publisher
- Adis
- Date of Publication
- 2017
- Physical Description
- 1 online resource (xv, 102 pages) : 6 illus. in color
- ISBN
- 9783319280400
- 9783319280394 (print ed.)
- Subjects (MeSH)
- Anti-Inflammatory Agents - therapeutic use
- Drug Delivery Systems
- Inflammation - drug therapy
- Interleukin-17 - immunology
- Interleukin-17- antagonists & inhibitors
- Th17 Cells - chemistry
- Abstract
- This book provides an overview of the discovery and structure of IL-17, including its pathogenesis and role in chronic inflammation and autoimmunity. To capture the latest developments and product approvals the book also discusses the therapeutic advances and looks at emerging therapies targeting the IL-17 pathway. IL-17 is a pro-inflammatory cytokine that has a key role in inflammation, autoimmunity, and host defense in a number of inflammatory disorders such as rheumatoid arthritis, psoriatic arthritis and psoriasis, ankylosing spondylitis, multiple sclerosis, and inflammatory bowel disease. The discovery of the IL-17-Th17 pathway has seen exciting development in the field of immunology and inflammation research, which has led to a number of recent regulatory approvals.
- Contents
- 1. Overview of the IL-17 Family -- 2. IL-17 in Host Defense -- 3. Th17 Cells: Differentiation and Regulation -- 4. The Role of IL-17/Th17 Pathway in the Pathogenesis of Autoimmune Inflammatory Diseases -- 5. Therapeutic Applications: Strategies and Molecules Targeting the IL-17/Th17 Pathway -- 6. Concluding Remarks
- Format
- e-Book
- Location
- Online
Target validation in drug discovery
https://libcat.nshealth.ca/en/permalink/provcat27190
editors, Brian W. Metcalf and Susan Dillon.
--Amsterdam, Netherlands:
Academic Press
, c2007.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Author
- Metcalf, Brian W
- Other Authors
- Dillon, Susan
- Responsibility
- editors, Brian W. Metcalf and Susan Dillon
- Place of Publication
- Amsterdam, Netherlands
- Publisher
- Academic Press
- Date of Publication
- c2007
- Physical Description
- xii, 279 p.
- ISBN
- 661070760X (electronic bk.)
- Subjects (MeSH)
- Drug Design
- Drug Delivery Systems
- Drug Evaluation
- Contents
- Cover -- Front Cover -- Table of Contents -- Preface -- Contributors -- PART I PHARMACEUTICAL BIOTECHNOLOGY FOR TARGET VALIDATION -- Chapter 1 Generation of Transgenic Animals -- I. INTRODUCTION -- II. GENERATION OF TRANSGENIC ANIMALS FOR TARGET VALIDATION -- III. CONCLUSION -- ACKNOWLEDGMENTS -- RECOMMENDED RESOURCES -- REFERENCES -- Chapter 2 Target Validation in Chemogenomics -- I. INTRODUCTION -- II. REVERSE CHEMOGENOMICS: TARGET VALIDATION USING COMPOUNDS WITH KNOWN MOLECULAR TARGET (AND/OR MECHANISM OF ACTION) -- III. FORWARD CHEMOGENOMICS: TARGET IDENTIFICATION/VALIDATION USING COMPOUNDS WITH UNKNOWN MECHANISM OF ACTION -- IV. CONCLUSION -- REFERENCES -- PART II TARGET VALIDATION FOR BIOPHARMACEUTICAL DRUG DISCOVERY -- Chapter 3 Cetuximab (Erbitux®), An Anti-Epidermal Growth Factor Receptor Antibody for the Treatment of Metastatic Colorectal Cancer -- I. INTRODUCTION -- II. EPIDERMAL GROWTH FACTOR RECEPTOR AND ITS ROLE IN HUMAN CANCER -- III. CETUXIMAB (ERBITUX®, IMC-C225) -- IV. CETUXIMAB IN CLINICAL STUDIES IN PATIENTS WITH mCRC -- V. MECHANISMS OF ACTION OF CETUXIMAB -- VI. CONCLUSIONS AND PERSPECTIVES -- RECOMMENDED RESOURCES -- REFERENCES -- Chapter 4 Monoclonal Antibody to HER-2 in Breast Cancer -- I. INTRODUCTION -- II. MECHANISM OF ACTION OF TRASTUZUMAB -- III. MOLECULAR MECHANISMS OF TRASTUZUMAB RESISTANCE -- IV. ASSESSMENT OF HER-2 STATUS -- V. CLINICAL TRIALS WITH TRASTUZUMAB -- CONCLUSION -- ACKNOWLEDGMENTS -- USEFUL WEBSITES -- REFERENCES -- Chapter 5 Validation of TNF as a Drug Target in Inflammatory Bowel Disease -- I. INTRODUCTION -- II. TUMOR NECROSIS FACTOR -- III. INFLAMMATORY BOWEL DISEASE -- IV. PATHOPHYSIOLOGY OF IBD AND THE PUTATIVE ROLE OF TNF -- V. CLINICAL EXPERIENCE WITH TNF-BLOCKING THERAPY IN IBD -- CONCLUSION -- ACKNOWLEDGMENTS -- REFERENCES -- Chapter 6 Anti-CCL-2/MCP-1: Directed Biologicals for Inflammatory and Malignant Diseases -- I. INTRODUCTION -- II. IN VITRO ASSAYS TO ESTABLISH THE PRO-INFLAMMATORY ACTIVITIES OF CCL-2 -- III. IN VIVO VALIDATION STUDIES -- IV. SUMMARY -- ACKNOWLEDGMENTS -- REFERENCES -- Chapter 7 Targeting IL-12p40 for Immune-Mediated Disease -- I. INTRODUCTION -- II. IN VITRO TARGET VALIDATION OF IL-12p40 -- III. IN VIVO PROOF-OF-CONCEPT FOR IL-12p40 INHIBITION -- IV. CONCLUSION -- RECOMMENDED RESOURCES -- REFERENCES -- Chapter 8 The GPIIb/IIIa Antagonist Abciximab for Acute Percutaneous Coronary Intervention -- I. INTRODUCTION -- II. RATIONALE FOR GPIIb/IIIa AS A TARGET IN CORONARY ARTERIAL DISEASE -- III. GENERATION OF THE 7E3 MONOCLONAL ANTIBODY AGAINST GPIIb/IIIa -- IV. IN VITRO STUDIES -- V. ANIMAL STUDIES -- VI. PLATELET PHARMACODYNAMIC PHENOMENA RECOGNIZED LATER -- VII. CROSS REACTIVITY WITH OTHER INTEGRINS -- VIII. INTEGRATION OF CLINICAL PHARMACOLOGY AND PRECLINICAL STUDIES -- IX. CLINICAL STUDIES -- X. CONCLUSION -- RECOMMENDED RESOURCES -- REFERENCES -- PART III VALIDATING TARGETS OF SMALL MOLECULE APPROACHES -- Chapter 9 Epidermal Growth Factor Receptor (EGFR) Inhibitor for Oncology: Discovery and Development of Erlotinib -- I. INTRODUCTION -- II. EPIDERMAL GROWTH FACTOR REC
- Format
- e-Book
- Location
- Online
