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Antiepileptic Drug Interactions : A Clinical Guide

https://libcat.nshealth.ca/en/permalink/provcat40233
Philip N. Patsalos. (3rd ed.) --Cham: Springer , c2016.
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This updated third edition of a successful book is a description of both pharmacokinetic and pharmacodynamic antiepileptic drug (AED) interactions, including details of the magnitude and mechanism of interactions, and also of drug combinations that are not associated with interactions and therefore can be coprescribed without undue concern. Presented in alphabetical order and by drug class, drug interactions that occur between AEDs and also between AEDs and non-AEDs are described in three secti…
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Author
Patsalos, Philip N
Responsibility
Philip N. Patsalos
Edition
3rd ed.
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2016
Physical Description
1 online resource (xlix, 340 p. : 31 illus.)
ISBN
9783319329093
9783319329086 (print ed.)
Subjects (MeSH)
Anticonvulsants
Drug Interactions
Epilepsy - drug therapy
Abstract
This updated third edition of a successful book is a description of both pharmacokinetic and pharmacodynamic antiepileptic drug (AED) interactions, including details of the magnitude and mechanism of interactions, and also of drug combinations that are not associated with interactions and therefore can be coprescribed without undue concern. Presented in alphabetical order and by drug class, drug interactions that occur between AEDs and also between AEDs and non-AEDs are described in three sections: Drug interactions between AEDs; Drug interactions between AEDs and non-AED Drugs: Interactions affecting AEDs; Drug interactions between AEDs and non-AED Drugs: Interactions affected by AEDs. Antiepileptic Drug Interactions: A Clinical Guide, 3rd Edition with its clear, concise and unambiguous content will allow physicians and allied health professionals to make more rational choices when AED polytherapy regimens are indicated. There is always a choice and avoiding highly interacting drugs and choosing drug combinations that are minimally interacting or do not interact should be the goal in treating patients with epilepsy. This book provides all the necessary information so as to allow this goal to be achieved and, if necessary, to aid effective management of AED interactions.
Contents
Section 1: Introduction -- Section 2: Drug Interactions Between AEDs -- Acetazolamide -- Carbamazepine -- Clobazam -- Clonazepam -- Ethosuximide -- Eslicarbazepine acetate -- Felbamate -- Gabapentin -- Lacosamide -- Lamotrigine -- Levetiracetam -- Methsuximide -- Oxcarbazepine -- Perampanel -- Phenobarbital -- Phenytoin -- Piracetam -- Pregabalin -- Primidone -- Retigabine -- Rufinamide -- Stiripentol -- Tiagabine -- Topiramate -- Valproic Acid -- Vigabatrin -- Zonisamide -- Section 3: Drug Interactions between AEDs and non-AED drugs: Interactions Affecting AEDs -- Acetazolamide -- Carbamazepine -- Clobazam -- Clonazepam -- Ethosuximide -- Eslicarbazepine acetate -- Felbamate -- Gabapentin -- Lacosamide -- Lamotrigine -- Levetiracetam -- Methsuximide -- Oxcarbazepine -- Perampanel -- Phenobarbital -- Phenytoin -- Piracetam -- Pregabalin -- Primidone -- Retigabine -- Rufinamide -- Stiripentol -- Tiagabine -- Topiramate -- Valproic Acid -- Vigabatrin -- Zonisamide -- Section 4: Drug Interactions between AEDs and non-AED drugs: Interactions Affected by AEDS -- Analgesics -- Antimicrobials -- Antineoplastic agents -- Antiulcer drugs -- Cardiovascular drugs -- Immunosuppressants -- Neuromuscular Blocking Agents -- Psychotropic Drugs -- Steroids -- Miscellanea.
Format
e-Book
Location
Online
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Antiepileptic drugs : combination therapy and interactions

https://libcat.nshealth.ca/en/permalink/provcat27219
Majkowski, Jerzy. --Cambridge, UK: Cambridge University Press , c2005.
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Location
Online
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Author
Majkowski, Jerzy
Place of Publication
Cambridge, UK
Publisher
Cambridge University Press
Date of Publication
c2005
Physical Description
496 p.
ISBN
6610202834
Subjects (MeSH)
Anticonvulsants
Drug Interactions
Drug Therapy, Combination
Epilepsy - drug therapy
Contents
Cover -- Half-title -- Title -- Copyright -- Contents -- List of contributors -- Foreword -- Foreword -- Acknowledgements -- Part I Introduction -- 1 Combination therapy of diseases: general concepts -- Historical aspects -- Polypharmacy -- Polytherapy -- Epidemiology of combination therapy -- Advantages of combination therapy -- Disadvantages of combination therapy -- Conclusions -- REFERENCES -- 2 Combination therapy with antiepileptic drugs: potential advantages and problems -- Rationale for combination therapy -- Potential advantages of combination therapy -- Evidence of benefits of combination therapy versus monotherapy -- Potential problems with combined AEDs -- Summary -- REFERENCES -- 3 Pharmacogenetic aspects -- Introduction -- Metabolism -- Central pharmacokinetics -- Pharmacodynamics -- Adverse events -- Misconceptions about the use of genetic tests -- REFERENCES -- Part II Pharmacokinetic interactions -- 4 Pharmacokinetic principles and mechanisms of drug interactions -- Introduction -- Mechanisms of drug interactions -- Absorption -- Distribution -- Metabolism -- Elimination -- REFERENCES -- 5 Predictability of metabolic antiepileptic drug interactions -- Principles of drug metabolism -- Major drug-metabolizing enzymes -- Enzyme induction and enzyme inhibition -- In vitro systems for testing drug metabolism and metabolic drug interactions -- Prediction of metabolic drug interactions based on in vitro data -- Crucial factors in predicting in vitro-in vivo correlations -- Conclusions -- REFERENCES -- 6 Influence of food and drugs on the bioavailability of antiepileptic drugs -- Introduction -- General principles -- Interactions with the established AEDs -- Interactions with other AEDs -- REFERENCES -- 7 Interactions between antiepileptic drugs -- Summary -- Introduction -- Interactions between classic AEDs (phenobarbital, phenytoin, primidone, carbamazepine, valproic acid, ethosuximide, methsuximide) and other AEDs -- Interactions between new AEDs and other AEDs -- Therapeutic implications -- REFERENCES -- 8 Interaction between antiepileptic and non-antiepileptic drugs -- Introduction -- Carbamazepine -- Ethosuximide -- Felbamate -- Gabapentin -- Lamotrigine -- Levetiracetam -- Oxcarbazepine -- Phenobarbital -- Phenytoin -- Primidone -- Tiagabine -- Topiramate -- Valproic acid -- Vigabatrin -- Zonisamide -- REFERENCES -- Part III Pharmacodynamic interactions -- 9 Pharmacodynamic principles and mechanisms of drug interactions -- Distinction between pharmacodynamic and pharmacokinetic drug interactions -- Types of pharmacodynamic interaction -- Clinical significance of pharmacodynamic interactions -- Desirable and undesirable pharmacodynamic interactions -- Clinical relevance of pharmacodynamic interactions: monotherapy versus combination therapy -- REFERENCES -- 10 Methods for assessing pharmacodynamic interactions -- Experimental methods -- Clinical methods -- REFERENCES -- 11
Format
e-Book
Location
Online
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Applied Clinical Pharmacokinetics and Pharmacodynamics of Psychopharmacological Agents

https://libcat.nshealth.ca/en/permalink/provcat40067
Michael W. Jann, Scott R. Penzak, Lawrence J. Cohen, editors. (1st ed.) --Cham: Springer International Publishing : Imprint: Adis , c2016.
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This book is a comprehensive resource on psychotropic medications, detailing the latest methods for defining their characteristics, their use in different patient populations, and drug-drug interactions; an important collection of information for clinicians, students, researchers, and members of the pharmaceutical industry alike. The first section provides the foundational principles of these drugs. Mathematical modeling of parameters that affect their entryto,and exit from, the central nervous…
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Other Authors
Jann, Michael W
Penzak, Scott R
Cohen, Lawrence J
Responsibility
Michael W. Jann, Scott R. Penzak, Lawrence J. Cohen, editors
Edition
1st ed.
Place of Publication
Cham
Publisher
Springer International Publishing : Imprint: Adis
Date of Publication
c2016
Physical Description
1 online resource (xiv, 601 p. : 100 illus., 50 illus. in color)
ISBN
9783319278834
9783319278810 (print ed.)
Subjects (MeSH)
Drug Interactions
Psychotropic Drugs - pharmacokinetics
Psychotropic Drugs - pharmacology
Abstract
This book is a comprehensive resource on psychotropic medications, detailing the latest methods for defining their characteristics, their use in different patient populations, and drug-drug interactions; an important collection of information for clinicians, students, researchers, and members of the pharmaceutical industry alike. The first section provides the foundational principles of these drugs. Mathematical modeling of parameters that affect their entryto,and exit from, the central nervous system (CNS) compartment are presented on an individual basis and then applied to target populations with specific disease states. Methods and characteristics that inform the transfer of these drugs from the laboratory bench to use in patient care are discussed, including imaging techniques, genetics and physiological barriers, such as the blood-brain barrier. The second section describes the characteristics of specific agents,nominally arranged intodifferent therapeutic categories and with reference crossover use in different disease states. The pharmacologic characteristics of different drug formulations are explored in the context of their ability to improve patient adherence. The third section focuses on drug-drug interactions.Psychotropic medications from different categories are frequently prescribed together, or alongside medications used to treat comorbid conditions, and the information provided is directly relevant to the clinic, as a result. The clinical application of pharmacokinetics and pharmacodynamics of CNS agents has made significant progress over the past 50 years and new information is reported by numerous publications in psychiatry, neurology, and pharmacology. Our understanding of the interrelationship between these medications, receptors, drug transporters, as well as techniques for measurement and monitoring their interactions, is frequently updated. However, with information presented on a host of different platforms, and in different formats, obtaining the full picture can be difficult. This title aims to collate this information into a single source that can be easily interpreted and applied towards patient care by the clinical practitioner, and act as a reference for all others who have an interest in psychopharmacological agents.
Contents
Section 1. General Pharmacokinetic and Pharmacodynamic Principles of Psychopharmacological Agents -- 1. Pharmacokinetic Properties -- 2. Pharmacodynamic Properties -- 3. PET Scan and Other Biomarkers -- 4. Population Pharmacokinetics -- 5. Drug Transporters (esp. Blood Brain Barrier) -- 6. Pharmacogenomics -- Section 2. Clinical Pharmacokinetics and Pharmacodynamics of Psychopharmacological Drug Classes -- 7. Antipsychotics: oral typical agents, oral atypical agents, and long-acting injectable (LAI) antipsychotics -- 8. Mood Stabilizers -- 9. Antidepressants: tricyclics, selective serotonergic reuptake inhibitors, serotonergic noradrenergic reuptake inhibitors, monoamine oxidase inhibitors, and other antidepressants -- 10. Benzodiazepines and Other Sedative Hypnotics/Anxiolytics -- 11. Opioid Analgesics -- 12. Stimulants and Other Non-Stimulants for ADHD -- 13. Cholinesterase Inhibitors and Other Antidementa Agents -- 14. Anti-Addiction Agents -- 15. Anesthetics -- Section 3. Clinically Significant Drug Interactions With Psychopharmacological Agents -- 16. Antipsychotics -- 17. Mood Stabilizers -- 18. Antidepressants -- 19. Benzodiazepines and Other Sedative Hypnotics/Anxiolytics -- 20. Opioid Analgesics -- 21. Stimulants and Other Non-Stimulants for ADHD -- 22. Cholinesterase Inhibitors and Other Antidementa Agents -- 23. Anti-Addiction Agents -- 24. Anesthetics.
Format
e-Book
Location
Online
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Cardiac drug eruptions and interactions

https://libcat.nshealth.ca/en/permalink/provcat22206
Litt, Jerome Z. --New York, NY: Taylor and Francis , 2005.
Call Number
WR 165 L776c 2005
Location
Halifax Infirmary
Call Number
WR 165 L776c 2005
Author
Litt, Jerome Z.
Place of Publication
New York, NY
Publisher
Taylor and Francis
Date of Publication
2005
Physical Description
149 p.
ISBN
1841846023
Subjects (MeSH)
Drug Eruptions
Drug Interactions
Pharmaceutical Preparations - administration & dosage
Format
Book
Location
Halifax Infirmary
Loan Period
3 weeks
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A Case Approach to Perioperative Drug-Drug Interactions

https://libcat.nshealth.ca/en/permalink/provcat38917
Catherine Marcucci, Michael P. Hutchens, Erica D. Wittwer, Toby N. Weingarten, Juraj Sprung, Wayne T. Nicholson, Kirk Lalwani, David G. Metro, Randal O. Dull, Christopher E. Swide, F. Jacob Seagull, Jeffrey R. Kirsch, Neil B. Sandson, editors. --New York, NY: Springer , c2015.
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The occurrence of deleterious or even fatal drug-drug interactions (DDIs) in the perioperative period is no longer a theoretical concern but a harrowing reality. A Case Approach to Perioperative Drug-Drug Interactions addresses the complex realm of pharmacokinetic drug interactions in an easy-to-read volume that functions as both a comprehensive clinical reference and a casebook. The book presents a summary of the core concepts of drug interactions; an organized, annotated presentation of the d…
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Other Authors
Marcucci, Catherine
Hutchens, Michael P
Wittwer, Erica D
Weingarten, Toby N
Sprung, Juraj
Nicholson, Wayne T
Lalwani, Kirk
Metro, David G
Dull, Randal O
Swide, Christopher E
Seagull, F. Jacob
Kirsch, Jeffrey R
Sandson, Neil B
Responsibility
Catherine Marcucci, Michael P. Hutchens, Erica D. Wittwer, Toby N. Weingarten, Juraj Sprung, Wayne T. Nicholson, Kirk Lalwani, David G. Metro, Randal O. Dull, Christopher E. Swide, F. Jacob Seagull, Jeffrey R. Kirsch, Neil B. Sandson, editors
Place of Publication
New York, NY
Publisher
Springer
Date of Publication
c2015
Physical Description
1 online resource (xliv, 1016 p. : 45 illus., 16 illus. in color)
ISBN
9781461474951
9781461474944 (print ed.)
Subjects (MeSH)
Drug Interactions
Perioperative Period
Abstract
The occurrence of deleterious or even fatal drug-drug interactions (DDIs) in the perioperative period is no longer a theoretical concern but a harrowing reality. A Case Approach to Perioperative Drug-Drug Interactions addresses the complex realm of pharmacokinetic drug interactions in an easy-to-read volume that functions as both a comprehensive clinical reference and a casebook. The book presents a summary of the core concepts of drug interactions; an organized, annotated presentation of the drug interactions most relevant to the perioperative clinician; and approximately 200 case scenarios that highlight specific drug interactions. This book fills a real void in the clinical literature and is invaluable to anesthesiologists and surgeons, and PharmDs, as well as trainees in those specialties; intensive care staff, including physicians, physician assistants, and nurses; and nurse practitioners who staff preoperative evaluation clinics.
Contents
Part I. Introduction to Drug–Drug Interactions -- Part II. Introduction to Drug–Drug Interactions: Brief Review of Cytochrome P450 (CYP450) Enzymes, Uridine 5’-diphosphoglucuronoslytransferases (UGTs), and Transporters -- Part III. Drug–Drug Interactions: Paradigms and Core Concepts -- Part IV. Drug–Drug Interactions Involving Inhalational Anesthetic Agents -- Part V. Drug–Drug Interactions Involving Intravenous Anesthetic Agents -- Part VI. Drug–Drug Interactions Involving Local Anesthetics -- Part VII. Drug–Drug Interactions Involving Opioids -- Part VIII. Drug–Drug Interactions Involving Non opioid Pain Medications -- Part IX. Drug–Drug Interactions Involving Benzodiazepines and Other Sedatives -- Part X. Drug–Drug Interactions Involving Neuromuscular Blockade Agents -- Part XI. Drug–Drug Interactions Involving Antibiotics and Antifungals -- Part XII. Drug–Drug Interactions Involving Cardiovascular Medications -- Part XIII. Drug–Drug Interactions Involving Coagulation Modifiers -- Part XIV. Drug–Drug Interactions Involving Immunosuppressants, Antiemetics, and Chemotherapy -- Part XV. Drug–Drug Interactions Involving Neuropsychiatric Drugs -- Part XVI. Drug–Drug Interactions Involving QT-Prolonging DDIs -- Part XVII. Drug–Drug Interactions Involving Foods and Nutrition -- Part XVIII. Drug–Drug Interactions Involving Spices and Supplements -- Fatal Forty Index -- Drug Index (Generic) --- Drug Index (Brand).
Format
e-Book
Publication Type
Case Reports
Location
Online
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Challenges in infectious diseases

https://libcat.nshealth.ca/en/permalink/provcat32392
I.W. Fong, editor. --New York, NY: Springer , c2013.
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This latest volume in the Emerging Infectious Diseases of the 21st Century series provides timely information and discussions on future approaches to controlling various infectious disease worldwide. Challenges in Infectious Diseases addresses numerous advances in medical-scientific knowledge, medical technology and biological and diagnostic techniques over the past decade. However recent developments have provided less dramatic changes or improvements in management of medical conditions. This …
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Other Authors
Fong, I.W. (Ignatius W.)
Responsibility
I.W. Fong, editor
Place of Publication
New York, NY
Publisher
Springer
Date of Publication
c2013
Physical Description
1 online resource (xii, 319 p.)
Series Title
Emerging infectious diseases of the 21st century
ISBN
9781461444961
Subjects (MeSH)
HIV infections
Parasitic Diseases
Tuberculosis, Multidrug-Resistant
Subjects (LCSH)
Immunology
Monoclonal antibodies
Drug interactions
Abstract
This latest volume in the Emerging Infectious Diseases of the 21st Century series provides timely information and discussions on future approaches to controlling various infectious disease worldwide. Challenges in Infectious Diseases addresses numerous advances in medical-scientific knowledge, medical technology and biological and diagnostic techniques over the past decade. However recent developments have provided less dramatic changes or improvements in management of medical conditions. This volume will address some of the emerging issues, challenges, and controversies of infectious diseases facing the global community today.
Contents
Preface -- HIV Epidemic -- Multidrug-resistant Bacteria: The Emerging Crisis -- Multidrug-Resistant Tuberculosis: A Global Challenge -- Urbanization and Infectious Diseases: General Principles, Historical Perspectives, and Contemporary Challenges -- Challenges in enteric epidemics from Cholera to malnutrition and cognitive development: barometers of inadequate water sanitation -- Challenges in control and eradication of malaria -- Lymphatic filariasis: progress and challenges in the move toward elimination -- Leishmaniasis: Challenges in the control and eradication -- Challenges in controlling and eliminating Schistosomiasis -- Dengue Infections -- Index.
Format
e-Book
Location
Online
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Clinical manual of drug interaction principles for medical practice

https://libcat.nshealth.ca/en/permalink/provcat24098
Gary H. Wynn ... [et al.]. --Washington, DC: American Psychiatric Pub. , 2009.
Call Number
QV 38 W988c 2009
Location
Halifax Infirmary
Call Number
QV 38 W988c 2009
Author
Wynn, Gary H.
Responsibility
Gary H. Wynn ... [et al.].
Place of Publication
Washington, DC
Publisher
American Psychiatric Pub.
Date of Publication
2009
Physical Description
xiii, 594 p.
ISBN
9781585622962
Subjects (MeSH)
Drug Interactions
Pharmacogenetics
Pharmacokinetics
Contents
Introduction to drug interactions and to this clinical manual / Gary H. Wynn -- Definitions and phase I metabolism / Gary H. Wynn -- Metabolism in depth: phase II / Michael H. Court -- Transporters / Jessica R. Oesterheld -- 2D6 / Jessica R. Oesterheld -- 3A4 / Jessica R. Oesterheld -- 1A2 / Miia R. Turpeinen -- 2C9 / Jessica R. Oesterheld -- 2C19 / Jessica R. Oesterheld -- 2E1 / Miia R. Turpeinen -- 2A6, 2B6, and 2C8 / Miia R. Turpeinen -- Gynecology : oral contraceptives / Jessica R. Oesterheld -- Internal medicine / Scott G. Williams -- Infectious diseases / Joseph Wise and Kelly l. Cozza -- Neurology / Gary H. Wynn -- Oncology / Scott G. Williams and Justin M. Curley -- Pain management I : nonnarcotic analgesics / Gary H. Wynn -- Pain management II : narcotic analgesics / Gary H. Wynn -- Psychiatry / Neil B. Sandson and Javier Muniz -- Transplant surgery and rheumatology / Gary H. Wynn -- Guidelines / Kelly l. Cozza -- Medicolegal implications of drug-drug interactions / David M. Benedek -- How to retrieve and review the literature / Kelly l. Cozza.
Format
Book
Location
Halifax Infirmary
Copies
2
Loan Period
3 weeks
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Clinical pharmacokinetic and pharmacodynamic drug interactions associated with antimalarials

https://libcat.nshealth.ca/en/permalink/provcat33949
Tony K.L. Kiang, Kyle John Wilby, Mary H.H. Ensom. --Cham, Switzerland: Adis , c2015.
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Location
Online
This comprehensive review provides a systematic, unbiased analysis, critique and summary of the available literature and generates novel clinical decision-making algorithms which can aid clinicians and scientists in practice management and research development. Potential mechanisms for the identified drug interactions are deduced from available preclinical and in vitro data which are interpreted in the context of the in vivo findings. Current limitations and gaps in the literature are summarize…
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Author
Kiang, Tony K. L
Other Authors
Wilby, Kyle John
Ensom, Mary H.H.
Responsibility
Tony K.L. Kiang, Kyle John Wilby, Mary H.H. Ensom
Place of Publication
Cham, Switzerland
Publisher
Adis
Date of Publication
c2015
Physical Description
1 online resource (vii, 146 pages)
ISBN
9783319105277 (electronic bk.)
9783319105260
Subjects (MeSH)
Antimalarials - pharmacokinetics
Drug interactions
Malaria - drug therapy
Subjects (LCSH)
Antimalarials - Pharmacokinetics
Antimalarials - Receptors - Effect of drugs on
Abstract
This comprehensive review provides a systematic, unbiased analysis, critique and summary of the available literature and generates novel clinical decision-making algorithms which can aid clinicians and scientists in practice management and research development. Potential mechanisms for the identified drug interactions are deduced from available preclinical and in vitro data which are interpreted in the context of the in vivo findings. Current limitations and gaps in the literature are summarized, and potential future research directions / experimentations are also suggested. In addition to the main objective to review the available clinical pharmacokinetic and pharmacodynamic drug interactions associated with WHO-recommended antimalarial drugs on the market today (i.e. chloroquine, amodiaquine, sulfadoxine, pyrimethamine, mefloquine, artemisinin, artemether, artesunate, dihydroartemisinin, artemotil, lumefantrine, primaquine, atovaquone, proguanil, piperaquine and quinine), this book also provides succinct chapter summaries on the epidemiology of malaria infection, diagnosis and therapeutics, in vivo pharmacology and chemistry, preclinical pharmacology, in vitro pharmacodynamics, in vitro reaction phenotyping, and in vitro drug-drug interaction data associated with the identified antimalarial drugs.
Contents
Introduction -- Pharmacology of Recommended Antimalarial Agents -- Drug Interaction Potential of Antimalarial Drugs Based on Known Metabolic Properties of Antimalarials -- Pharmacokinetic Drug Interactions Affecting Antimalarials -- Effects of Antimalarials on the Pharmacokinetics of Co-Administered Drugs -- Effects of Antimalarials on the Pharmacokinetics of Co-Administered Antimalarials -- Pharmacodynamic Interactions: Clinical Evidence for Combination Therapy, In Vitro Interactions, and In Vivo Interactions -- Limitations, Future Directions, and Conclusions.
Format
e-Book
Location
Online
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Canadian Pharmacists Association. --Ottawa, ON: Canadian Pharmacists Association
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Location
Online
e-Therapeutics+ is a comprehensive drug information resource produced by the Canadian Pharmacists Association. It includes the following: > e-CPS: the online edition of the Compendium of Pharmaceuticals and Specialties (CPS), containing information on proprietary and nonproprietary Canadian drugs intended for human use; > Therapeutic Choices: the condensed online version of CPhA's reputable text on treatment options for conditions and diseases; > Drug interaction analyzer [PEPID] that provides …
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Corporate Author
Canadian Pharmacists Association
Alternate Title
e Therapeutics plus
eTherapeutics
Therapeutic choices
e-Therapeutics+
e-CPS
eCPS
Compendium of pharmaceuticals and specialties
PEPID
CPS
Continues
RxTx
e-Therapeutics+
eCPS
Place of Publication
Ottawa, ON
Publisher
Canadian Pharmacists Association
Subjects (MeSH)
Therapeutics
Drug Therapy
Drug Interactions
Pharmaceutical Preparations
Pharmacopoeias - Canada
Abstract
e-Therapeutics+ is a comprehensive drug information resource produced by the Canadian Pharmacists Association. It includes the following: > e-CPS: the online edition of the Compendium of Pharmaceuticals and Specialties (CPS), containing information on proprietary and nonproprietary Canadian drugs intended for human use; > Therapeutic Choices: the condensed online version of CPhA's reputable text on treatment options for conditions and diseases; > Drug interaction analyzer [PEPID] that provides drug-to-drug interaction information; > Patient information: printable self-care information for patients written in plain language, available in English and French; > New safety information: links to Health Canada advisories, warnings and recalls directly from applicable drug monographs.
Contents
Therapeutic choices -- e-CPS -- Drug interactions -- Information for patients.
Format
Database
Publication Type
Database
Location
Online
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Drug interaction facts 2015 : the authority on drug interactions

https://libcat.nshealth.ca/en/permalink/provcat38419
editor, David S. Tatro. --St. Louis, MO: Wolters Kluwer Health , 2015.
Call Number
QV 39 D794 2015
Location
Cape Breton Regional
Call Number
QV 39 D794 2015
Other Authors
Tatro, David S.
Responsibility
editor, David S. Tatro
Place of Publication
St. Louis, MO
Publisher
Wolters Kluwer Health
Date of Publication
2015
Physical Description
lviii, 2486 p.
ISBN
9781574393637 (pbk.)
1574393634 (pbk.)
Subjects (MeSH)
Drug Interactions
Drug Therapy, Combination
Subjects (LCSH)
Drug interactions--Handbooks, manuals, etc.
Chemotherapy, Combination--Handbooks, manuals, etc.
Format
Book
Location
Cape Breton Regional
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Drug Interactions in Infectious Diseases

https://libcat.nshealth.ca/en/permalink/provcat30018
Stephen C. Piscitelli, Keith A. Rodvold, Manjunath P. Pai, editors. (3rd ed.) --Totowa, NJ: Springer Science+Business Media , c2011.
Available Online
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Location
Online
Available Online
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Other Authors
Piscitelli, Stephen C
Rodvold, Keith A
Pai, Manjunath P
Responsibility
Stephen C. Piscitelli, Keith A. Rodvold, Manjunath P. Pai, editors
Edition
3rd ed.
Place of Publication
Totowa, NJ
Publisher
Springer Science+Business Media
Date of Publication
c2011
Series Title
Infectious disease
ISBN
9781617792137
Subjects (MeSH)
Anti-Infective Agents - pharmacology
Anti-Infective Agents - therapeutic use
Communicable Diseases - drug therapy
Communicable Diseases - complications
Drug Interactions
Subjects (LCSH)
Pharmacy
Infectious diseases
Contents
1. Introduction to Drug-Drug Interactions -- 2. Mechanisms of Drug Interactions I: Absorption, Metabolism, and Excretion -- 3. Mechanisms of Drug Interactions II: Transport Proteins -- 4. Drug-Food Interactions -- 5. Interactions Between Herbs and Antiinfective Medications -- 6. Drug-Cytokine Interactions -- 7. Beta-Lactam Antibiotics -- 8. Macrolides, Azalides, and Ketolides -- 9. Quinolones -- 10. Glycopeptides, Lipopeptides, and Lipoglycopeptides -- 11. Miscellaneous Antibiotics -- 12. Drugs for Tuberculosis -- 13. Drug Interactions with Antiretrovirals for HIV Infection -- 14. Non-HIV Antiviral Agents -- 15. Antifungal Agents -- 16. Antimalarial Agents -- 17. Antiprotozoal and Anthelmintic Agents -- 18. Drug Interaction Considerations Throughout Drug Development -- 19. Probe Cocktail Studies -- 20. Design and Data Analysis in Drug Interaction Studies.
Format
e-Book
Location
Online
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Drug interactions in infectious diseases

https://libcat.nshealth.ca/en/permalink/provcat22162
Piscitelli, Stephen C. (2nd ed.) --Totowa, NJ: Human Kinetics | Humanics Press , 2005.
Call Number
QV 38 P636d 2005
Location
Halifax Infirmary
Call Number
QV 38 P636d 2005
Author
Piscitelli, Stephen C.
Other Authors
Rodvold, Keith A.
Edition
2nd ed.
Place of Publication
Totowa, NJ
Publisher
Human Kinetics
Humanics Press
Date of Publication
2005
Physical Description
534 p.
ISBN
1588294552
Subjects (MeSH)
Drug Interactions
Communicable Diseases - complications
Format
Book
Location
Halifax Infirmary
Loan Period
3 weeks
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Drug Interactions in Infectious Diseases : Antimicrobial Drug Interactions

https://libcat.nshealth.ca/en/permalink/provcat43114
Manjunath P. Pai, Jennifer J. Kiser, Paul O. Gubbins, Keith A. Rodvold, editors. (Fourth edition) --Cham: Humana Press , c2018.
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Location
Online
The 4th edition of Drug Interactions in Infectious Diseases is being split into two separate volumes—"Mechanisms and Models of Drug Interactions" and "Antimicrobial Drug Interactions". This volume, "Antimicrobial Drug Interactions," delivers a quick clinical resource that distills relevant drug interactions by antimicrobial drug class. The book provides informative tables on specific drug-drug interactions that include the degree and severity of the expected interaction. A mechanistic basis for…
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Other Authors
Pai, Manjunath P.
Kiser, Jennifer J.
Gubbins, Paul O.
Rodvold, Keith A
Responsibility
Manjunath P. Pai, Jennifer J. Kiser, Paul O. Gubbins, Keith A. Rodvold, editors
Edition
Fourth edition
Place of Publication
Cham
Publisher
Humana Press
Date of Publication
c2018
Physical Description
1 online resource (xvi, 565 p.) : 2 illus., 1 illus. in color
Series Title
Infectious disease
ISBN
9783319724164
9783319724157 (print ed.)
9783319724171 (print ed.)
9783030101978 (print ed.)
Subjects (MeSH)
Anti-Infective Agents - pharmacology
Anti-Infective Agents - therapeutic use
Communicable Diseases - drug therapy
Drug Interactions
Specialty
Infectious Disease Medicine
Pharmacology
Abstract
The 4th edition of Drug Interactions in Infectious Diseases is being split into two separate volumes—"Mechanisms and Models of Drug Interactions" and "Antimicrobial Drug Interactions". This volume, "Antimicrobial Drug Interactions," delivers a quick clinical resource that distills relevant drug interactions by antimicrobial drug class. The book provides informative tables on specific drug-drug interactions that include the degree and severity of the expected interaction. A mechanistic basis for drug-drug interactions is also provided to link observed interactions to pharmacologic characteristics of key drug classes. This complete resource is organized by major antibacterial, antimycobacterial, antiviral, antifungal, antimalarial, and antiprotozoal class. In line with current innovations in antimicrobial drug development, a distinct chapter on the pharmacologic management of drug interactions in hepatitis B virus (HBV) and hepatitis C virus (HCV)-related infections is included. Two new chapters are dedicated to the management of human immunodeficiency virus (HIV) drug-drug interactions given the breadth of antiretroviral class-specific effects. This comprehensive review of known drug interactions and strategies to manage them is an invaluable resource to all health care practitioners.
Contents
Beta-Lactam Antibiotics -- Macrolides, Azalides, and Ketolides -- Quinolones -- Glycopeptides, Lipopeptides, and Lipoglycopeptides -- Miscellaneous Antibiotics -- Drugs for Tuberculosis -- Drug Interactions in HIV: Protease and Integrase Inhibitors -- Drug Interactions in HIV: Nucleoside, Nucleotide, and Nonnucleoside Reverse Transcriptase Inhibitors and Entry Inhibitors -- Hepatitis B and Hepatitis C Antiviral Agents -- Drug Interactions of Non-HIV Antiviral Agents -- Antifungal Agents -- Antimalarial Agents -- Antiprotozoal and Anthelminthic Agents.
Format
e-Book
Location
Online
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Drug Interactions in Infectious Diseases : Mechanisms and Models of Drug Interactions

https://libcat.nshealth.ca/en/permalink/provcat43084
Manjunath P. Pai, Jennifer J. Kiser, Paul O. Gubbins, Keith A. Rodvold, editors. (Fourth edition) --Cham: Humana Press , c2018.
Available Online
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Location
Online
The 4th edition of Drug Interactions in Infectious Diseases is being split into two separate volumes—"Mechanisms and Models of Drug Interactions" and "Antimicrobial Drug Interactions". This volume, "Mechanisms and Models of Drug Interactions," delivers a text that enhances clinical knowledge of the complex mechanisms, risks, and consequences of drug interactions associated with antimicrobials, infection, and inflammation. The book provides a comprehensive review of basic clinical pharmacology w…
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Other Authors
Pai, Manjunath P.
Kiser, Jennifer J.
Gubbins, Paul O.
Rodvold, Keith A.
Responsibility
Manjunath P. Pai, Jennifer J. Kiser, Paul O. Gubbins, Keith A. Rodvold, editors
Edition
Fourth edition
Place of Publication
Cham
Publisher
Humana Press
Date of Publication
c2018
Physical Description
1 online resource (xvi, 326 p.) : 8 illus., 5 illus. in color
Series Title
Infectious disease
ISBN
9783319724225
9783319724218 (print ed.)
9783319724232 (print ed.)
9783030101985 (print ed.)
Subjects (MeSH)
Drug Interactions
Food-Drug Interactions
Herb-Drug Interactions
Specialty
Infectious Disease Medicine
Pharmacology
Abstract
The 4th edition of Drug Interactions in Infectious Diseases is being split into two separate volumes—"Mechanisms and Models of Drug Interactions" and "Antimicrobial Drug Interactions". This volume, "Mechanisms and Models of Drug Interactions," delivers a text that enhances clinical knowledge of the complex mechanisms, risks, and consequences of drug interactions associated with antimicrobials, infection, and inflammation. The book provides a comprehensive review of basic clinical pharmacology with a focus on metabolism and transporter-mediated drug interactions. The chapters address materials that cannot be retrieved easily in the medical literature, including materials focused on the complex interrelationship of acute infection, inflammation, and the risk of drug interactions in the Drug-Cytokine chapter. The Food-Drug and Herb-Drug interactions chapters remain definitive resources. A new chapter on in vitro modeling of drug interactions is included along with updates on design and data analysis of clinical drug interaction studies. Authoritative discussion of models for regulatory decision-making on drug-drug interactions provides the necessary framework to aid antimicrobial drug development. This concise review of the mechanisms and models of drug interactions provides important insights to health care practitioners as well as scientists in drug development.
Contents
Introduction to Drug-Drug Interactions -- Mechanisms of Drug Interactions I: Absorption, Metabolism, and Excretion -- Mechanisms of Drug Interactions II: Transport Proteins -- Drug-Food Interactions -- Drug-Cytokine Interactions -- Interactions between Herbs and Antiinfective Medications -- In vitro Modeling of Drug-Drug Interactions -- Probe Cocktail Studies -- Design and Data Analysis in Drug Interaction Studies.
Format
e-Book
Location
Online
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DrugPoints system

https://libcat.nshealth.ca/en/permalink/provcat30740
IBM Watson Health. --[Cambridge, MA]: IBM , c2020.
Available Online
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Location
Online
Available Online
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Corporate Author
IBM Watson Health
Place of Publication
[Cambridge, MA]
Publisher
IBM
Date of Publication
c2020
Subjects (MeSH)
Drug Interactions
Pharmacokinetics
Pharmaceutical Preparations
Specialty
Pharmacy
Format
Database
Publication Type
Pharmacopoeias
Location
Online
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Drug resistance in leishmania parasites : consequences, molecular mechanisms and possible treatments

https://libcat.nshealth.ca/en/permalink/provcat32519
Alicia Ponte-Sucre, Emilia Diaz, Maritza Padrón-Nieves, editors. --Vienna: Springer , c2013.
Available Online
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Location
Online
One of the main problems concerning therapeutic tools for the treatment of parasitic diseases, including leishmaniasis, is that some field parasites are naturally resistant to the classical drugs; additionally, current therapies may select parasites prone to be resistant to the applied drugs. These features are (at least partially) responsible for the disappointing persistence of the disease and resultant deaths worldwide. This book provides a comprehensive view of the pathology of the disease…
Available Online
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Other Authors
Ponte-Sucre, Alicia
Diaz, Emilia
Padrón-Nieves, Maritza
Responsibility
Alicia Ponte-Sucre, Emilia Diaz, Maritza Padrón-Nieves, editors
Place of Publication
Vienna
Publisher
Springer
Date of Publication
c2013
Physical Description
1 online resource (xiv, 459 p. : 44 ill., 24 ill. in color)
ISBN
9783709111253
Subjects (MeSH)
Drug Resistance
Leishmania - drug effects
Leishmaniasis
Subjects (LCSH)
Vaccines
Drug interactions
Parasitology
Pharmaceutical technology
Infectious diseases
Microbiology
Abstract
One of the main problems concerning therapeutic tools for the treatment of parasitic diseases, including leishmaniasis, is that some field parasites are naturally resistant to the classical drugs; additionally, current therapies may select parasites prone to be resistant to the applied drugs. These features are (at least partially) responsible for the disappointing persistence of the disease and resultant deaths worldwide. This book provides a comprehensive view of the pathology of the disease itself, and of parasitic drug resistance, its molecular basis, consequences and possible treatments. Scientists both from academic fields and from the industry involved in biomedical research and drug design, will find in this book a valuable and fundamental guide that conveys the knowledge needed to understand and to improve the success in combating this disease worldwide.
Contents
Foreword -- Introduction. Leishmaniasis, the biology of a parasite. Alicia Ponte Sucre -- I Determinant features in leishmaniasis -- 1 Molecular evolution and phylogeny of Leishmania. Gabriele Schoenian, Elisa Cupolillo, Isabel Mauricio -- 2 The role of reservoirs: Canine leishmaniasis. Lenea Campino, Carla Maia -- 3 Epidemiology of leishmaniasis in the time of drug resistance. Jean Claude Dujardin, Saskya Decuypere -- II Leishmania and the immune system -- 4 The role of the immune system in resistance to infection. Lukasz Kedzierski, Krystal J. Evans -- 5 Vaccination as a control measure. Katrin Forber , Heidrun Moll -- 6 Leishmania vaccines: Past, Present and Future. Bhavana Sethu Lakshmi, Rentala Madhubala.- III Challenges in the diagnosis, treatment and control of leishmaniasis in times of drug resistance -- 7 Co-infection with HIV. Margriet den Boer, Luis Rivas, Jorge Alvar.- 8 Visceral leishmaniasis. Shyam Sundar , J aya Chakravarty -- 9 American Tegumentary leishmaniasis. Olga Zerpa, Alicia Ponte-Sucre -- IV Molecular features of drug-resistant Leishmania -- 10 Genetic expression and drug resistance, the role of proteomics. Patricia Cuervo, Jose Batista de Jesus.- 11 The role of ABC transporters in drug-resistant Leishmania. Adriano C Coelho, Paulo C Cotrim -- 12 Functional analysis of Leishmania membrane (non ABC) transporters involved in drug resistance. Scott M Landfear -- 13 Intracellular mechanisms of resistance in Leishmania -- V Pharmacology and chemotherapy of leishmaniasis. Mitali Chatterjee -- 14 Classical vs new Treatment regimens. Louis Maes, Raquel Andreia Inocencio da Luz, Paul Cos, Vanessa Yardley -- 15 Drug targets, drug effectors and drug targeting and delivery. Philippe M Loiseau, Gillian Barratt -- 16 Mechanisms of miltefosine resistance in Leishmania. Francisco Gamarro, Maria P Sanchez-Cacete, Santiago Castanys -- 17 P-glycoprotein-like transporters in Leishmania: a search for reversal agents. Bruno Pradines.- VI Strategies to circumvent drug resistance in Leishmania -- 18 The relevance of susceptibility tests, breakpoints and markers. Louis Maes, Paul Cos and Simon Croft -- 19 The Concept of Fitness and drug resistance in Leishmania. Alicia Ponte-Sucre, Emilia Diaz, Maritza Padron-Nieves.
Format
e-Book
Location
Online
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Drugs for pregnant and lactating women

https://libcat.nshealth.ca/en/permalink/provcat42512
Carl P. Weiner, Clifford Mason. (3rd ed.) --Philadelphia, PA: Elsevier , c2019.
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Location
Online
Comprehensive and easy to use, Drugs for Pregnant and Lactating Women, 3rd Edition, remains your #1 resource for reliable information on virtually all of today’s drugs and herbal supplements and how they interact with pregnancy and lactation. This logically organized reference has been frequently emulated, but not duplicated. The 3rd Edition has been thoroughly updated to keep you current with new drugs, changes in FDA labeling, and more in-depth information on interactions. Designed for ease …
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Author
Weiner, Carl P.
Other Authors
Mason, Clifford
Responsibility
Carl P. Weiner, Clifford Mason
Edition
3rd ed.
Alternate Title
Drugs for pregnant & lactating women
Place of Publication
Philadelphia, PA
Publisher
Elsevier
Date of Publication
c2019
Physical Description
1 online resource, 1170 p.
ISBN
9780323428743
Subjects (MeSH)
Breast Feeding - adverse effects
Contraindications - handbooks
Drug-Related Side Effects and Adverse Reactions
Fetus - drug effects
Infant
Pharmaceutical Preparations - Handbooks
Pregnancy Complications - chemically induced
Pregnancy - drug effects
Subjects (LCSH)
Drug interactions--Handbooks, manuals, etc.
Fetus--Effect of drugs on
Specialty
Pharmacology
Perinatology
Abstract
Comprehensive and easy to use, Drugs for Pregnant and Lactating Women, 3rd Edition, remains your #1 resource for reliable information on virtually all of today’s drugs and herbal supplements and how they interact with pregnancy and lactation. This logically organized reference has been frequently emulated, but not duplicated. The 3rd Edition has been thoroughly updated to keep you current with new drugs, changes in FDA labeling, and more in-depth information on interactions. Designed for ease of use in the clinical setting, it provides the key drug information needed by physicians, nurses, physician assistants, and others involved in the care of pregnant and lactating women.
Access
Registration required for PDF access.
Format
e-Book
Location
Online
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Drugs-nutrients : an interaction guide

https://libcat.nshealth.ca/en/permalink/provcat20891
Locong, Alice. --Laval, PQ: Les Presses de l'Universite Laval , 2000.
Call Number
QV 39 L819g 2000
Location
Dickson Building
Call Number
QV 39 L819g 2000
Author
Locong, Alice
Place of Publication
Laval, PQ
Publisher
Les Presses de l'Universite Laval
Date of Publication
2000
ISBN
2763777012
Subjects (MeSH)
Food-Drug Interactions - physiology - Handbooks
Pharmaceutical Preparations - adverse effects - Handbooks
Format
Book
Location
Dickson Building
Copies
2
Loan Period
3 weeks
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Drug Therapy and Interactions in Pediatric Oncology : A Pocket Guide

https://libcat.nshealth.ca/en/permalink/provcat41334
Carolina Witchmichen Penteado Schmidt, Fabiana Gatti de Menezes. --Cham: Springer , 2017.
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Location
Online
There are few publications about drug interactions in chemotherapy and even less about pediatric oncology treatment. For this reason, the present book is intended to offer guidelines about drug interactions for physicians, pharmacists and the other healthcare professionals involved in the chemotherapy of pediatric patients. In this book the reader will have access to a primary introduction for the major diseases in pediatric oncology, followed by the major therapeutic protocols. Following that,…
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Author
Penteado Schmidt, Carolina Witchmichen
Other Authors
de Menezes, Fabiana Gatti
Responsibility
Carolina Witchmichen Penteado Schmidt, Fabiana Gatti de Menezes
Place of Publication
Cham
Publisher
Springer
Date of Publication
2017
Physical Description
1 online resource (xxi, 212 pages) : 15 illus. in color
ISBN
9783319388724
9783319388717 (print ed.)
Subjects (MeSH)
Antineoplastic Agents
Drug Interactions
Drug-Related Side Effects and Adverse Reactions - prevention & control
Neoplasms - drug therapy
Abstract
There are few publications about drug interactions in chemotherapy and even less about pediatric oncology treatment. For this reason, the present book is intended to offer guidelines about drug interactions for physicians, pharmacists and the other healthcare professionals involved in the chemotherapy of pediatric patients. In this book the reader will have access to a primary introduction for the major diseases in pediatric oncology, followed by the major therapeutic protocols. Following that, the most important drug interactions in pediatric oncology treatment are presented and discussed in detail. Finally, important topics such as Drug-Food Interactions are addressed. Drug Therapy and Interactions in Pediatric Oncology focuses in great detail on the drug interactions in Pediatric Oncohematology and will be an indispensable resource in daily practice for a wide range of health providers.
Contents
1. Introduction -- 2. The main diseases in pediatric hemato-oncology -- 3. The main protocols in pediatric oncohematology -- 4. Background of drug interactions -- 5. Drug-food interactions -- Appendix -- Glossary.
Format
e-Book
Location
Online
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Handbook of Drug-Nutrient Interactions

https://libcat.nshealth.ca/en/permalink/provcat30168
edited by Joseph I. Boullata, Vincent T. Armenti ; foreword by Gil Hardy. (Second edition) --New York: Humana Press , c2010.
Available Online
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Location
Online
Available Online
View e-Book
Other Authors
Boullata, Joseph I.
Armenti, Vincent T.
Hardy, Gil
Responsibility
edited by Joseph I. Boullata, Vincent T. Armenti ; foreword by Gil Hardy
Edition
Second edition
Place of Publication
New York
Publisher
Humana Press
Date of Publication
c2010
Physical Description
1 online resource (xxvii, 821 p.)
Series
Nutrition and Health
Series Title
Nutrition and health (Totowa, N.J.)
ISBN
9781603273626
9781603273633 (print ed.)
Subjects (MeSH)
Food-Drug Interactions - Handbooks
Contents
PART I: APPROACHING DRUG–NUTRIENT INTERACTIONS -- 1. An Introduction to Drug–Nutrient Interactions -- 2. Drug Disposition and Response -- 3. Drug Transporters -- 4. Drug-Metabolizing Enzymes -- 5. Nutrient Disposition and Response -- PART II: INFLUENCE OF NUTRITION STATUS ON DRUG DISPOSITION AND EFFECT -- 6. Influence of Protein-Calorie Malnutrition on Medication -- 7. Influence of Overweight and Obesity on Medication -- PART III: INFLUENCE OF FOOD, NUTRIENTS, OR SUPPLEMENTATION ON DRUG DISPOSITION AND EFFECT -- 8. Drug Absorption with Food -- 9. Effects of Specific Foods and Dietary Components on Drug Metabolism -- 10. Grapefruit and Other Fruit Juices Interactions with Medicines -- 11. Positive Drug–Nutrient Interactions -- 12. Interaction of Natural Products with Medication and Nutrients -- 13. Drug–Nutrient Interactions in Patients Receiving Enteral Nutrition -- 14. Drug–Nutrient Interactions in Patients Receiving Parenteral Nutrition -- PART IV: INFLUENCE OF MEDICATION ON NUTRITION STATUS, NUTRIENT DISPOSITION, AND EFFECT -- 15. Drug-Induced Changes to Nutritional Status -- 16. Influence of Cardiovascular Medication on Nutritional Status -- 17. Influence of Neurological Medication on Nutritional Status -- 18. Drug–Nutrient Interactions Involving Folate -- 19. Drug–Nutrient Interactions That Impact on Mineral Status -- PART V: DRUG–NUTRIENT INTERACTIONS BY LIFE STAGE -- 20. Drug–Nutrient Interactions in Infancy and Childhood -- 21. Drug–Nutrient Interaction Considerations in Pregnancy and Lactation -- 22. Drug–Nutrient Interactions in the Elderly -- PART VI: DRUG–NUTRIENT INTERACTIONS IN SPECIFIC CONDITIONS -- 23. Drug–Nutrient Interactions and Immune Function -- 24. Drug–Nutrient Interactions in Patients with Cancer -- 25. Drug–Nutrient Interactions in Transplantation -- 26. Drug–Nutrient Interactions in Patients with Chronic Infections.
Format
e-Book
Location
Online
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