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Collagenase in Dupuytren Disease

https://libcat.nshealth.ca/en/permalink/provcat42589
Giorgio Pajardi, Marie A. Badalamente, Lawrence C. Hurst, editors. --Cham: Springer , c2018.
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This book offers detailed guidance on the use of collagenase, or enzymatic fasciotomy, as a nonsurgical treatment for Dupuytren's contracture and explains its role in relation to the other forms of treatment, including open fasciectomy, needle aponeurotomy, and lipofilling. Clear guidance is provided on technique, current indications, and off-label usage. With the help of tips and tricks from leading experts, the reader will learn how to personalize the procedure to meet the needs of individual…
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Pajardi, Giorgio
Badalamente, Marie A.
Hurst, Lawrence C.
Responsibility
Giorgio Pajardi, Marie A. Badalamente, Lawrence C. Hurst, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2018
Physical Description
1 online resource (xi, 142 p.) : 50 illus., 47 illus. in color
ISBN
9783319658223
9783319658216 (print ed.)
9783319658230 (print ed.)
Subjects (MeSH)
Collagenases - therapeutic use
Dupuytren Contracture - therapy
Specialty
Rheumatology
Abstract
This book offers detailed guidance on the use of collagenase, or enzymatic fasciotomy, as a nonsurgical treatment for Dupuytren's contracture and explains its role in relation to the other forms of treatment, including open fasciectomy, needle aponeurotomy, and lipofilling. Clear guidance is provided on technique, current indications, and off-label usage. With the help of tips and tricks from leading experts, the reader will learn how to personalize the procedure to meet the needs of individual patients. Advice is also provided on all aspects of rehabilitation, which is a key determinant of treatment outcome. Collagenase treatment of Dupuytren's disease has the benefits of low invasiveness and rapid patient recovery and achieves reasonable recurrence-free periods. It is especially valuable in patients with rapid recurrence following surgery. In documenting and appraising every aspect of its use, this book will be of value for all who treat patients with Dupuytren's disease, including hand surgeons, orthopedists, plastic surgeons, physiatrists, and physiotherapists.
Contents
1. Biochemistry and Mechanism of Action of Collagenase on Collagen -- 2. Collagenase: Preclinical Evaluation and Clinical Trials in the USA and Australia -- 3. The Normal Fibrous Skeleton of the Hand and Changes in Dupuytren’s Contracture -- 4. Collagenase in Europe from the Experimental Phase to Practical Use -- 5. Preparation, Injection and Traction Procedures (Pearls and Tips and Tricks): Technical Evolution and Results in Severe Cases -- 6. Dupuytren’s Disease of the Thumb and First Web -- 7. Rehabilitation After Treatment -- 8. Follow-up Studies, Satisfaction, Recurrence, Dosage and Drug Safety -- 9. American and European Regulations -- 10. Collagenase: Future Perspectives.
Format
e-Book
Location
Online
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Dupuytren Disease and Related Diseases : The Cutting Edge

https://libcat.nshealth.ca/en/permalink/provcat41315
Paul M. N. Werker, Joseph Dias, Charles Eaton, Bert Reichert, Wolfgang Wach, editors. --Cham: Springer , 2017.
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In this book, leading international experts showcase the latest advances in research into Dupuytren disease and its clinical management. The coverage spans all relevant specialties, including cell biology, biomechanics, genomics, surgery, pharmacotherapy, and radiotherapy. The opening sections address epidemiology, cellular and extracellular events, and genetics. Treatment by means of collagenase injection, percutaneous needle fasciotomy, and other surgical and minimally invasive approaches is …
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Werker, Paul M. N.
Dias, Joseph
Eaton, Charles
Reichert, Bert
Wach, Wolfgang
Other Authors
International Conference on Dupuytren Disease (2015 : Groningen Netherlands)
Responsibility
Paul M. N. Werker, Joseph Dias, Charles Eaton, Bert Reichert, Wolfgang Wach, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
2017
Physical Description
1 online resource (xvii, 450 pages) : 170 illus., 150 illus. in color
ISBN
9783319321998
9783319321974 (print ed.)
Subjects (MeSH)
Dupuytren Contracture
Fibroma
Abstract
In this book, leading international experts showcase the latest advances in research into Dupuytren disease and its clinical management. The coverage spans all relevant specialties, including cell biology, biomechanics, genomics, surgery, pharmacotherapy, and radiotherapy. The opening sections address epidemiology, cellular and extracellular events, and genetics. Treatment by means of collagenase injection, percutaneous needle fasciotomy, and other surgical and minimally invasive approaches is then extensively discussed. Comparative studies of different approaches are reviewed, and aspects of patient assessment, examined. The prevention and treatment of disease recurrences are also addressed. Further sections consider related conditions, other treatment options, and future pathways for research. This book should be read by all who treat or conduct research into Dupuytren disease. It is based on presentations delivered at the 2015 International Conference on Dupuytren Disease, held in Groningen, the Netherlands, which was designed to promote a coordinated global response to the disease involving patients, scientists, and clinicians.
Contents
Part I. Epidemiology and Patients -- Part II. Cellular and Extra-cellular Events, Pathogenesis -- Part III. Genetics and Associations -- Part IV. Collagenase Injection -- Part V. Percutaneous Needle Fasciotomy (PNF) -- Part VI. Assessment -- Part VII. Comparative Studies and Economics -- Part VIII. Surgical Techniques and Recurrence -- Part IX. Related Diseases and Other Treatments -- Part X. Future Paths of Research.
Format
e-Book
Publication Type
Congress
Location
Online
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Dupuytren's Contracture : A Clinical Casebook

https://libcat.nshealth.ca/en/permalink/provcat39938
Marco Rizzo, editor. --Cham: Springer , c2016.
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Comprised exclusively of clinical cases involving Dupuytren's contracture, this concise, practical casebook will provide clinicians in orthopedics and hand surgery with the best real-world strategies to properly diagnose and treat this recurrent disease of the fascia. Each chapter is a case that opens with a unique clinical presentation, followed by a description of the diagnosis, assessment and management techniques used to treat it, as well as the case outcome and clinical pearls and pitfalls…
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Rizzo, Marco
Responsibility
Marco Rizzo, editor
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2016
Physical Description
1 online resource (xiii, 273 p. : 122 illus., 115 illus. in color)
ISBN
9783319238418
9783319238401 (print ed.)
Subjects (MeSH)
Dupuytren Contracture - diagnosis
Dupuytren Contracture - surgery
Dupuytren Contracture - therapy
Abstract
Comprised exclusively of clinical cases involving Dupuytren's contracture, this concise, practical casebook will provide clinicians in orthopedics and hand surgery with the best real-world strategies to properly diagnose and treat this recurrent disease of the fascia. Each chapter is a case that opens with a unique clinical presentation, followed by a description of the diagnosis, assessment and management techniques used to treat it, as well as the case outcome and clinical pearls and pitfalls. Initial chapters discuss non-operative treatments ranging from orthosis/tissue mobilization, corticosteroid injections, needle aponeurotomy and collagenase injections. Various surgical interventions follow, including fasciotomy, fasciectomy, open palm, and dermatofasciectomy. Chapters discussing the use of skin grafting, illustrating the special challenges associated with revision surgery, and "end of the line" interventions such as arthrodesis and amputation are also included. Less common aspects of Dupuytren's are reviewed as well, as are cases that address treatment and special consideration in younger patients, the role/use of dynamic external fixators in Dupuytren's care, correction of distal interphalangeal (DIP) joint contractures and treatment of dorsal finger (Garrod's) nodes. Pragmatic and reader-friendly, Dupuytren's Contracture: A Clinical Casebook will be an excellent resource for orthopedic and hand surgeons alike.
Contents
1. Nonoperative Management of Finger Flexion Contracture in Dupuytren’s Disease: Orthotic Intervention and Tissue Mobilization Techniques -- 2 Needle Aponeurotomy in the Management of Dupuytren’s Contracture -- 3. Ultrasound Assisted Needle Aponeurotomy in the Management of Dupuytren’s Contracture -- 4. Corticosteroid Injections and Needle Aponeurotomy in the Management of Dupuytren’s Contracture -- 5. Clostridial Collagenase Injections in the Treatment of Dupuytren’s Contracture -- 6. Minimally Invasive Partial Fasciectomy -- 7. Surgical Fasciotomy for Dupuytren’s Contracture -- 8. Surgical Fasciectomy for Dupuytren’s Contracture -- 9. Wide Awake Dupuytren’s Fasciectomy: A Pathoanatomical Approach -- 10. Surgical Open Palm (McCash) Technique -- 11. Treatment of Dupuytren’s Contracture with Dermofasciectomy -- 12. Surgical Fasciectomy for Recurrent Disease -- 13. Use of Dynamic External Fixator (Digit Widget) in Dupuytren’s Contracture -- 14. The Distal Interphalangeal Joint in Dupuytren’s Disease -- 15. Knuckle Pads (Garrod’s Nodules) of the Fingers: Painful Dorsal Nodules on the PIP Joints of the Fingers and Concomitant Recurrent Dupuytren’s Contracture -- 16. Arthrodesis in Treatment of Dupuytren Contracture -- 17. Amputation in Management of Severe Dupuytren’s Contracture -- 18. Treatment of Dupuytren’s Contracture in the Young -- 19. Recurrent Dupuytren Contracture Treated with Fasciectomy and Skin Grafting.
Format
e-Book
Publication Type
Case Reports
Location
Online
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Dupuytren's Disease and Related Hyperproliferative Disorders : Principles, Research, and Clinical Perspectives

https://libcat.nshealth.ca/en/permalink/provcat31132
Charles Eaton .. [et al.], editors. --Berlin, Heidelberg: Springer , c2012.
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Until a cure exists, Dupuytren's disease and related disorders such as Ledderhose's disease will pose lifelong threats of functional impairment for affected individuals. A better understanding of the onset of disease, early detection and functional preservation are of the utmost importance to minimize the impact of these conditions. This book is based on presentations and discussions at the 2010 International Symposium on Dupuytren's disease held in Miami, Florida, but it also includes new dat…
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Other Authors
Eaton, Charles
Responsibility
Charles Eaton .. [et al.], editors
Place of Publication
Berlin, Heidelberg
Publisher
Springer
Date of Publication
c2012
Physical Description
1 online resource (xxiii, 474 p. : 253 ill., 198 ill. in color)
ISBN
9783642226977
Subjects (MeSH)
Dupuytren Contracture
Subjects (LCSH)
Dermatology
Orthopedics
Orthopedic surgery
Abstract
Until a cure exists, Dupuytren's disease and related disorders such as Ledderhose's disease will pose lifelong threats of functional impairment for affected individuals. A better understanding of the onset of disease, early detection and functional preservation are of the utmost importance to minimize the impact of these conditions. This book is based on presentations and discussions at the 2010 International Symposium on Dupuytren's disease held in Miami, Florida, but it also includes new data and additional chapters. It is hoped that it will raise awareness of this underestimated condition and promote cooperative efforts to work towards a cure. Up to date information is provided on the epidemiology, biology, and pathology of the disease. The principles and specifics of treatment are explored in detail. The indications for and techniques of radiotherapy, minimally invasive treatments and open surgery are fully explained. In addition, the role of physical therapy is considered as well as the care of relapse and complications. Treatment of Ledderhose's disease and Peyronie's disease is also discussed. This book provides invaluable information for hand surgeons, podiatrists, orthopedists, plastic surgeons, radiation therapy specialists and general practitioners. It will help to foster an interdisciplinary approach to the understanding and management of this debilitating disorder and related conditions.
Contents
[Machine generated contents note] Pt. I Anatomy, Pathology, and Pathophysiology / Charles Eaton -- 1. Dupuytren’s Disease: Anatomy, Pathology, and Presentation / Ghazi M. Rayan -- 2. Palmar Fibromatosis or the Loss of Flexibility of the Palmar Finger Tissue: A New Insight into the Disease Process of Dupuytren Contracture / Albrccht Meincl -- 3. Basic Thoughts on Dupuytren’s Contracture / Hanno Millesi -- 4. High Prevalence of Dupuytren’s Disease and Its Treatment in the British National Health Service: An Ongoing Demand / Ardcshir Bayat -- 5. Treatment for Dupuytren’s Disease: An Overview of Options / Paul M.N. Werker -- 6. Dupuytren’s Disease and Occupation / Alexis Descatha -- pt. II Myofibroblast / Giulio Gabbiani -- 7. Role of the Myofibroblast in Dupuytren’s Disease: Fundamental Aspects of Contraction and Therapeutic Perspectives / Giulio Gabbiani -- 8. Mechanisms of Myofibroblast Differentiation / Sem H. Phan -- 9. Myofibroblasts and Interactions with Other Cells: Contribution of the Tissue Engineering / Carlos Lopez-Valle -- 10. Dupuytren’s Contracture Versus Burn Scar Contracture / Paul Zidel -- pt. III Genetics and Demographics / Ardeshir Bayat -- 11. Genetic Basis of Dupuytren’s Disease: An Introduction / Hans C. Hennies -- 12. Use of Genetic and Genomic Analyses Tools to Study Dupuytren’s Disease / Ardeshir Bayat -- 13. Establishing an Animal Model of Dupuytren’s Contracture by Profiling Genes Associated with Fibrosis / Sandeep Kathju -- 14. Microarray Expression Analysis of Primary Dupuytren’s Contracture Cells / Ivana Ratkaj -- 15. Clinical Genetic Study of Familial Dupuytren’s Disease in the Netherlands / Guido H.C.G. Dolmans -- 16. The Epidemiology of Dupuytren’s Disease in Bosnia / Dragan Zerajic -- Pt. IV Collagen and Cell Biology -- 17. Primer of Collagen Biology: Synthesis, Degradation, Subtypes, and Role in Dupuytren’s Disease / Susan Emeigh Hart -- 18. Expression of Collagen-Degrading Proteases Involved in Dupuytren’s Disease Fibroblast-Mediated Contraction / Ian M. Clark -- 19. Primary Dupuytren’s Disease Cell Interactions with the Extra-cellular Environment: A Link to Disease Progression? / David B. O’Gorman -- 20. Insulin-Like Growth Factor Binding Protein-6: A Potential Mediator of Myofibroblast Differentiation in Dupuytren’s Disease? / David B. O’Gorman -- 21. Dupuytren’s Disease Shows Populations of Hematopoietic and Mesenchymal Stem-Like Cells Involving Perinodular Fat and Skin in Addition to Diseased Fascia: Implications for Pathogenesis and Therapy / Ardeshir Bayat -- 22. Using Laboratory Models to Develop Molecular Mechanistic Treatments for Dupuytren’s Disease / Wyatt G. Payne -- pt. V Surgical Treatment / Paul M.N. Werker -- 23. Plastic Surgical Management of Scars and Soft Tissue Contractures / Paul M.N. Werker -- 24. Cline’s Contracture: Dupuytren Was a Thief - A History of Surgery for Dupuytren’s Contracture / Teresa J. Pianta -- 25. Cellulose Implants in Dupuytren’s Surgery / Luc De Smet -- 26. Expanded Dermofasciectomies and Full-Thickness Grafts in the Treatment of Dupuytren’s Contracture: A 36-Year Experience / Lynn D. Ketchum -- 27. Minimizing Skin Necrosis and Delayed Healing After Surgical Treatment for Dupuytren’s Contracture: The Mini-Chevrons Incision / Michael Papaloizos -- 28. Skin Management in Treatment of Severe PIP Contracture by Homo- or Heterodigital Flaps / Moritz Lukas -- 29. "Jacobsen Flap" for the Treatment of Stage III-IV Dupuytren’ Dupuytren’s Disease at Little Finger: Our Review of 123 Cases / Massimiliano Tripoli -- 30. A Logical Approach to Release of the Contracted Proximal Interphalangeal Joint in Dupuytren’s Disease / Paul Smith -- 31. Influence of Dupuytren’s Disease on Trigger Fingers and Vice Versa / Bernd Kuehlein -- 32. No Higher Self-Reported Recurrence in Segmental Fasciectomy / Ilse Degreef -- 33. Palmar Cutaneous Branches of the Proper Digital Nerves Encountered in Dupuytren’s Surgery: A Cadaveric Study / Ian S.H. McNab -- pt. VI Needle Release and Hand Therapy / Paul M. N. Werker -- 34. Technique of Needle Aponeurotomy for Dupuytren’s Contracture / Charles Eaton -- 35. Three-Year Results of First-Ever Randomized Clinical Trial on Treatment in Dupuytren’s Disease: Percutaneous Needle Fasciotomy Versus Limited Fasciectomy / Paul M.N. Werker -- 36. Management of Dupuytren’s Disease with Needle Aponeurotomy: The Experience at the Hand and Upper Limb Centre, Canada / Bing Siang Gan -- 37. Percutaneous Needle Fasciotomy: A Serious Alternative? / Bernhard Lukas -- 38. Dynamic External Fixation in the Treatment of Dupuytren’s Contracture / Anthony A. Smith -- 39. Hand Therapy for Dupuytren’s Contracture / Charles Eaton -- 40. Severity of Contracture and Self-Reported Disability in Patients with Dupuytren’s Contracture Referred for Surgery / Debbie Larson -- 41. Night-Time Splinting After Fasciectomy or Dermofasciectomy for Dupuytren’s Contracture: A Pragmatic, Multi-centre, Randomised Controlled Trial / Susan P. Vaughan -- 42. Role of Static Night Splinting After Contracture Release for Dupuytren’s Disease: A Preliminary Recommendation Based on Clinical Cases / Albrecht Meinel -- pt. VII Additional and New Treatment Options / M. Heinrich Seegenschmiedt -- 43. Injectable Collagenase (Clostridium histolyticum) for Dupuytren’s Contracture: Results of the CORD I Study / Marie A. Badalamente -- 44. Long-Term Outcome of Radiotherapy for Early Stage Dupuytren’s Disease: A Phase III Clinical Study / Michael Heinrich Seegenschmiedt -- 45. Outcomes of Using Bioengineered Skin Substitute (Apligraf®) for Wound Coverage in Dupuytren’s Surgery / Anna-Lena Makowski -- 46. Highly Dosed Tamoxifen in Therapy-Resisting Dupuytren’s Disease / Luc De Smet -- 47. Screening of Prodrugs on Cells Grown from Dupuytren’s Disease Patients / Davor Jurisic -- 48. Relaxin: An Emerging Therapy for Fibroproliferative Disorders / Chrishan S. Samuel -- 49. Cryotherapy and Other Therapeutical Options for Plantar Fibromatosis / Terry L. Spilken -- 50. Long-Term Outcome of Radiotherapy for Primary and Recurrent Ledderhose Disease / Fabian Fehlauer -- 51. Medical Management of Peyronie’s Disease / Wayne J.G. Hellstrom -- pt. VIII Future Perspectives / Charles Eaton -- 52. Patient’s Perspective and the International Dupuytren Society / Wolfgang Wach -- 53. IDUP: Proposal for an International Research Database / Wolfgang Wach -- 54. Future of Dupuytren’s Research and Treatment / Charles Eaton.
Format
e-Book
Location
Online
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