Part I. Seizures, Epileptiform Activities, and Regional Localization -- 1. How Can We Identify Ictal and Interictal Abnormal Activity? -- 2. What Is the Clinical Relevance of In Vitro Epileptiform Activity? -- 3. What Is the Importance of Abnormal "Background" Activity in Seizure Generation? -- 4. What Is a Seizure Focus? -- 5. What Is a Seizure Network? Long-Range Network Consequences of Focal Seizures -- 6. What Is a Seizure Network? Very Fast Oscillations at the Interface Between Normal and Epileptic Brain -- 7. Is There Such a Thing as "Generalized" Epilepsy? -- Part II. Synaptic Plasticity -- 8. Are There Really "Epileptogenic" Mechanisms or Only Corruptions of "Normal" Plasticity? -- 9. When and How Do Seizures Kill Neurons, and Is Cell Death Relevant to Epileptogenesis? -- 10. How Is Homeostatic Plasticity Important in Epilepsy? -- 11. Is Plasticity of GABAergic Mechanisms Relevant to Epileptogenesis? -- 12. Do Structural Changes in GABA Neurons Give Rise to the Epileptic State? -- 13. Does Mossy Fiber Sprouting Give Rise to the Epileptic State? -- 14. Does Brain Inflammation Mediate Pathological Outcomes in Epilepsy? -- 15. Are Changes in Synaptic Function That Underlie Hyperexcitability Responsible for Seizure Activity? -- 16. Does Epilepsy Cause a Reversion to Immature Function? -- 17. Are Alterations in Transmitter Receptor and Ion Channel Expression Responsible for Epilepsies? -- Part III. Models and Methods -- 18. How Do We Make Models That Are Useful in Understanding Partial Epilepsies? -- 19. Aligning Animal Models with Clinical Epilepsy: Where to Begin? -- 20. What Non-neuronal Mechanisms Should Be Studied to Understand Epileptic Seizures? -- 21. What Epilepsy Comorbidities Are Important to Model in the Laboratory? Clinical Perspectives -- 22. Epilepsy Comorbidities: How Can Animal Models Help? -- 23. What New Modeling Approaches Will Help Us Identify Promising Drug Treatments? -- 24. What Are the Arguments For and Against Rational Therapy for Epilepsy? -- 25. How Can Advances in Epilepsy Genetics Lead to Better Treatments and Cures? -- 26. How Might Novel Technologies Such as Optogenetics Lead to Better Treatments in Epilepsy?