topic:"Gene expression profiling - methods" found 3 records - Provincial Hospitals Library Catalogue

DNA microarrays

https://libcat.nshealth.ca/en/permalink/provcat22397

Nuber, Ulrike A. --New York, NY: Taylor and Francis , 2005.

Call Number: QU 450 D629 2005

Location: Halifax Infirmary

Call Number: QU 450 D629 2005

Author: Nuber, Ulrike A

Place of Publication: New York, NY

Publisher: Taylor and Francis

Date of Publication: 2005

Physical Description: 299 p.

Series Title: BIOS advanced methods

ISBN: 0415358663

Subjects (MeSH): Oligonucleotide Array Sequence Analysis - methods; Gene expression profiling - methods

Format: Book

Location: Halifax Infirmary

Loan Period: 3 weeks

Gene expression profiling by microarrays : clinical implications

https://libcat.nshealth.ca/en/permalink/provcat27262

edited by Wolf-Karsten Hofmann. --Cambridge, UK: Cambridge University Press , 2006.

Available Online: View e-Book

Location: Online

Available Online: View e-Book

Author: Hofmann, Wolf-Karsten

Responsibility: edited by Wolf-Karsten Hofmann

Place of Publication: Cambridge, UK

Publisher: Cambridge University Press

Date of Publication: 2006

Physical Description: xiv, 246 p.

ISBN: 6610480400 (electronic bk.)

Subjects (MeSH): Gene expression profiling - methods; Oligonucleotide Array Sequence Analysis

Contents: Cover -- Half-title -- Title -- Copyright -- Dedication -- Contents -- Contributors -- Editor -- Foreword -- Contributors -- Foreword -- Introduction -- 1 Technique of microarrays: microarray platforms -- Introduction -- Microarray platforms -- cDNA microarrays -- Oligonucleotide microarrays -- Novel microarray platforms -- Target-labeling -- Microarray image analysis -- Accuracy and reliability of microarray platforms -- Outlook -- References -- 2 Quantitative quality control of microarray experiments: toward accurate gene expression measurements -- Introduction -- Accurate information acquisition from microarrays -- Quantitative data filtering and normalization, advantages of the quality score approach -- Quality measures from cyanine images -- Quality measures from the TD image -- R-Q LOWESS normalization and its efficiency -- Qf-weighted mean and t-test -- The accuracy of gene expression measurements by microarrays -- Discussion and conclusions -- Acknowledgments -- References -- 3 Statistical analysis of gene expression data -- Abstract -- Introduction -- Statistical background and challenges with microarray data -- Data processing -- Data acquisition and computation expression indices -- Spotted arrays -- Affymetrix arrays -- Quality control (QC) -- Gene filtering: identifying differentially expressed genes -- Observational filtering metrics -- Statistical filtering metrics -- Correction for multiple testing/false discovery rate -- Significance analysis of microarrays (SAM) -- Clustering/data visualization: unsupervised learning -- Hierarchical clustering -- Self-organizing maps (SOM) -- Principal components (PCA) -- Additional clustering techniques -- Classification/prediction: supervised learning -- Prediction models -- Model assessment and validation -- Experimental design -- Spotted array design -- Sample allocation -- Sample size -- References -- 4 Genomic stratification in patients with heart failure -- Introduction -- Animal models of HF -- Hypertrophy and HF -- Akt and apoptosis -- Tumor necrosis factor-Alpha (TNF-Alpha) -- Alpha1b-adrenergic receptor (Alpha1b-AR) -- Atrial natriuretic peptide (ANP) ablation -- Development, progression and rescue of HF in animal models -- Myocardial infarction -- Pressure overload -- Pharmacologic induction of heart failure -- Animal models of cardiac conductance abnormality -- A mouse heart gene expression database -- Cardiac development and the fetal gene program of HF -- Human HF -- Left ventricular assist devices in human HF -- Final common pathway? -- Peripheral blood mononuclear cell profiling in HF -- Conclusions -- References -- 5 Gene expression profiling for the diagnosis of acute leukemias -- Introduction -- Characterization of acute myeloid leukemia by microarray analyses -- Class prediction in AML -- Approaching class discovery in AML -- Comparison of protein expression and gene expression levels as assessed by flow cytometry and microarrays -- Prognostic studies in AML based on genetic profi