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ABC of clinical genetics

https://libcat.nshealth.ca/en/permalink/provcat52752
[by] Helen M. Kingston. (3rd ed.) --London, England: BMJ Books , 2002.
Call Number
QZ 50 K55 2002
Location
IWK Health Sciences Library
Call Number
QZ 50 K55 2002
Author
Kingston, Helen
Responsibility
[by] Helen M. Kingston
Edition
3rd ed.
Place of Publication
London, England
Publisher
BMJ Books
Date of Publication
2002
Physical Description
120 p.
ISBN
727916270
Subjects (MeSH)
Genetics, Medical
Format
Book
Location
IWK Health Sciences Library
Copies
1
Loan Period
2 weeks
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Abnormal Skeletal Phenotypes : From Simple Signs to Complex Diagnoses

https://libcat.nshealth.ca/en/permalink/provcat29247
by Alessandro Castriota-Scanderbeg, Bruno Dallapiccola. --Berlin, Heidelberg: Springer-Verlag , c2005.
Available Online
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Location
Online
Available Online
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Author
Castriota-Scanderbeg, Alessandro
Other Authors
Dallapiccola, Bruno
Responsibility
by Alessandro Castriota-Scanderbeg, Bruno Dallapiccola
Place of Publication
Berlin, Heidelberg
Publisher
Springer-Verlag
Date of Publication
c2005
ISBN
9783540303619
Subjects (MeSH)
Abnormalities, Multiple - diagnosis
Abnormalities, Multiple - diagnostic imaging
Bone Diseases - genetics
Bone and Bones - diagnostic imaging
Bone and Bones - abnormalities
Phenotype
Radiography
Subjects (LCSH)
Genetics
Orthopedics
Radiology Medical
Format
e-Book
Location
Online
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Acute Exacerbation of Chronic Hepatitis B : Volume 1. Definition, Research Technology, Virology, Genetics and Immunology

https://libcat.nshealth.ca/en/permalink/provcat44504
Qin Ning, editor. --Dordrecht: Springer , c2019.
Available Online
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Location
Online
This book assembles recent achievements in both basic research and clinical management in the field of hepatology, virology and immunology. It provides up-to-date information for clinicians who can apply the relevant knowledge to their daily clinical practice and for researchers who are interested in clinically orientated studies. The updated and detailed technology, state-of–the-art treatment strategies provided in this book serve as references for clinicians and resident physicians in the dai…
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Other Authors
Ning, Qin
Responsibility
Qin Ning, editor
Place of Publication
Dordrecht
Publisher
Springer
Date of Publication
c2019
Physical Description
1 online resource (xxiii, 369 p.) : 55 illus., 44 illus. in color
ISBN
9789402416060
9789402416046 (Print ed.)
9789402416053 (Print ed.)
Subjects (MeSH)
Disease Progression
Hepatitis B, Chronic - genetics
Hepatitis B, Chronic - immunology
Hepatitis B, Chronic - virology
Specialty
Gastroenterology
Virology
Abstract
This book assembles recent achievements in both basic research and clinical management in the field of hepatology, virology and immunology. It provides up-to-date information for clinicians who can apply the relevant knowledge to their daily clinical practice and for researchers who are interested in clinically orientated studies. The updated and detailed technology, state-of–the-art treatment strategies provided in this book serve as references for clinicians and resident physicians in the daily management of ACLF. The rationality and strategies for basic research as well as patient management in this book can also be a valuable reference for other fatal and end stage liver diseases than HBV induced ACLF. This volume 1 has 6 chapters and focuses on the definition, research technology, virology, genetics, and immunology.
Contents
1. Introduction to Acute Exacerbation of Chronic Hepatitis B (AECHB) -- 2. Research Methods and Techniques for Acute Exacerbation of Chronic Hepatitis B -- 3. Virological Factors Involved in AECHB -- 4. Host Genetic Characters of Acute Exacerbation of Chronic Hepatitis B (AECHB) -- 5. Immunological Features of AECHB -- 6. Other Precipitating Factors for AECHB.
Format
e-Book
Location
Online
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Acute myelogenous leukemia : genetics, biology and therapy

https://libcat.nshealth.ca/en/permalink/provcat30141
--New York, NY: Springer-Verlag , c2010.
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Location
Online
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Other Authors
Nagarajan, Lalitha
Place of Publication
New York, NY
Publisher
Springer-Verlag
Date of Publication
c2010
Series Vol.
145
Series Title
Cancer treatment and research
ISBN
9780387692593
Subjects (MeSH)
Leukemia, Myeloid, Acute - genetics
Leukemia, Myeloid, Acute - therapy
Subjects (LCSH)
Hematology
Oncology
Format
e-Book
Location
Online
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Advances in DNA repair in cancer therapy

https://libcat.nshealth.ca/en/permalink/provcat32399
Lawrence Panasci, Raquel Aloyz, Moulay Alaoui-Jamali, editors. --New York, NY: Springer , c2013.
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Location
Online
This book deals with the emerging role of various DNA repair proteins and the regulatory elements which are implicated in cancer therapy such as DNA cross-linking agents, radiotherapy and bleomycin. The DNA repair genes discussed include those involved in BRCA/Rad51-related homologous recombinational repair, DNA-PK related nonhomologous endjoining and the nucleotide excision repair gene, ERCC1. Moreover, the role of regulatory genes such as PARP, ATR, telomerase, growth factor receptors and dow…
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Other Authors
Panasci, Lawrence
Aloyz, Raquel
Alaoui-Jamali, Moulay
Responsibility
Lawrence Panasci, Raquel Aloyz, Moulay Alaoui-Jamali, editors
Place of Publication
New York, NY
Publisher
Springer
Date of Publication
c2013
Physical Description
1 online resource (viii, 312 p. : 35 ill., 25 ill. in color)
Series Vol.
72
Series Title
Cancer drug discovery and development
ISBN
9781461447412
Subjects (MeSH)
Antineoplastic Agents - therapeutic use
DNA Repair
Neoplasms - drug therapy
Neoplasms - genetics
Subjects (LCSH)
Oncology
Abstract
This book deals with the emerging role of various DNA repair proteins and the regulatory elements which are implicated in cancer therapy such as DNA cross-linking agents, radiotherapy and bleomycin. The DNA repair genes discussed include those involved in BRCA/Rad51-related homologous recombinational repair, DNA-PK related nonhomologous endjoining and the nucleotide excision repair gene, ERCC1. Moreover, the role of regulatory genes such as PARP, ATR, telomerase, growth factor receptors and downstream kinase signalling is examined.
Contents
Repair of DNA interstrand cross-links produced by cancer chemotherapeutic drugs -- DNA-PK, a pharmacological target in cancer chemotherapy and radiotherapy -- Growth factor receptor signaling, DNA damage response, and cancer cell susceptibility to chemotherapy and relapses -- Relationship between DNA-repair genes, cellular radiosensitivity, and the response of tumors annd normal tissues to radiotherapy -- Important roles of ERCCI in DNA repair and targeted therapy -- The role of BRCA1 and BRCA2 in anticancer drug therepy -- DNA-PK in CLL chemotherapy -- Poly (ADP) ribose polymerase at the interface of DNA damage signaling and DNA repair -- Cellular protection against the antitumor drug bleomycin -- ATR as a therapeutic target -- Telomores, Telomerase, and DNA damage response in cancer therapy -- RAD51 is a key protein of DNA repair and homologous recombination in humans -- Index.
Format
e-Book
Location
Online
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Advances in Vision Research. Volume I, Genetic Eye Research in Asia and the Pacific

https://libcat.nshealth.ca/en/permalink/provcat41924
Gyan Prakash, Takeshi Iwata, editors. --Tokyo: Springer , 2017.
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Location
Online
This book presents the state of the art in genetic eye research in Asia and the Pacific. Though there has been an explosion of information on genetic eye research in western countries, more than sixty percent of the human genes involved in eye diseases in the Asian and Pacific population remain unknown. However, new efforts and a new awareness have sparked important discussions on the subject, and new plans are being implemented to discover the genes responsible for many eye diseases in the pop…
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Other Authors
Prakash, Gyan
Iwata, Takeshi
Responsibility
Gyan Prakash, Takeshi Iwata, editors
Alternate Title
Genetic Eye Research in Asia and the Pacific
Place of Publication
Tokyo
Publisher
Springer
Date of Publication
2017
Physical Description
1 online resource (xv, 523 pages) : 71 illus., 55 illus. in color
Series Title
Essentials in ophthalmology
ISBN
9784431565116
9784431565093 (print ed.)
ISSN
1612-3212
Subjects (MeSH)
Eye diseases - genetics
Biomedical Research
Other Subjects
Asia
Abstract
This book presents the state of the art in genetic eye research in Asia and the Pacific. Though there has been an explosion of information on genetic eye research in western countries, more than sixty percent of the human genes involved in eye diseases in the Asian and Pacific population remain unknown. However, new efforts and a new awareness have sparked important discussions on the subject, and new plans are being implemented to discover the genes responsible for many eye diseases in the population. The book reviews the latest findings; its content ranges from genetic aspects of human migration to DNA sequence analysis, genome-wide association analysis, and disease phenotypes. The efforts of the Asian Eye Genetic Consortium (AEGC) are also discussed. The book's editors have been instrumental in developing strategies for discovering the new Asian genes involved in many eye diseases. All chapters were written by leading researchers working on Asian eye genetics from the fields of Human Genetics, Ophthalmology, Molecular Biology, Biochemistry, Sensory Sciences, and Clinical Research. Advances in Vision Research, Volume I will prove to be a major resource for all researchers, clinicians, clinical researchers, and allied eye health professionals with an interest in eye diseases among the Asian population.
Contents
1. Foundation of Asian Eye Genetics Consortium (AEGC) -- 2. Japan consortium for whole exome analysis of hereditary retinal diseases -- 3. Whole-genome sequencing in genetic eye diseases in China -- 4. Targeted exome sequencing in Japanese patients with Retinitis Pigmentosa -- 5. Genetic Epidemiology of Congenital Cataracts and Autosomal Recessive Retinal Degenerations in Pakistan -- 6. Genetics of Cataract in Asia -- 7. Genetic analysis of families with retinal dystrophies -- 8. Whole genome sequencing in patients with Retinitis Pigmentosa -- 9. Retinitis pigmentosa in Korean patients -- 10. Retinitis pigmentosa in Chinese population -- 11. Retinitis Pigmentosa in Japanese Population -- 12. Cone Dysfunction Syndrome in Japanese Population -- 13. Leber Congenital Amaurosis/Early-Onset Retinal Dystrophy in Japanese Population -- 14. Paradigm of Susceptibility genes in AMD and PCV -- 15. Genetics and Pathology of Inflammatory Components on AMD -- 16. Genome wide association study of age-related eye diseases in Chinese population -- 17. Clinical Genetics of Retinoblastoma: An Asian Perspective -- 18. Molecular and Clinical Genetics of Retinoblastoma -- 19. Current research Perspectives in Understanding Diabetic Retinopathy -- 20. Genome-wide association studies of glaucoma -- 21. Genetic Complexity of Primary Angle Closure Glaucoma in Asians -- 22. Genotype-phenotype correlation for POAG in the Middle East Khaled Abu-Amero (Saudi Arabia), Alta-- 23. Corneal Dystrophies in India -- 24. Genetics of Corneal Endothelial Dystrophies: An Asian Perspective -- 25. Keratoconus in Asia -- 26. Genetics of Pediatric Eye Diseases and Strabismus in Asia -- 27. Keratoconus: Globally and in the Middle East; Epidemiology, Genetics and future Research -- 28. Genetics of Myopia -- 29. Ocular Implications of Gaucher Disease -- 30. Genetic background of Uveitis in Chinese population -- 31. Usher Syndrome in Chinese and Japanese Population -- 32. Homozygosity Mapping for Autosomal Recessive Ocular Diseases -- 33. Tools of Genetic Eye Research and Need for Clinical Research Collaborations -- 34. Eye Genetics: The Road Ahead to Quality Standards -- 35. Genetic Counselling in Asia -- 36. Epigenetic study in Asian Eye Diseases -- 37. Unique Asian Patients Population: An Opportunity for Drug Development -- 38. A Perspective: How can gene therapeutics help address ophthalmic health issues in Asia?
Format
e-Book
Location
Online
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Aging and the heart : A Post-Genomic View

https://libcat.nshealth.ca/en/permalink/provcat28046
by José Marín-García, Michael J. Goldenthal, Gordon W. Moe. --Boston, MA: Springer Science+Business Media , c2008.
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Location
Online
Available Online
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Author
Marín-García, José
Other Authors
Goldenthal, Michael J
Moe, Gordon W
Responsibility
by José Marín-García, Michael J. Goldenthal, Gordon W. Moe
Place of Publication
Boston, MA
Publisher
Springer Science+Business Media
Date of Publication
c2008
ISBN
9780387740720
Subjects (MeSH)
Aging - physiology
Cardiovascular Diseases - genetics
Cardiovascular Diseases - physiopathology
Subjects (LCSH)
Cardiology
Geriatrics
Format
e-Book
Location
Online
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Allergy frontiers. Vol. 1, Epigenetics, allergens and risk factors

https://libcat.nshealth.ca/en/permalink/provcat29105
--Tokyo: Springer Japan , c2009.
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Location
Online
Available Online
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Other Authors
Pawankar, Ruby
Holgate, Stephen T
Rosenwasser, Lanny J
Place of Publication
Tokyo
Publisher
Springer Japan
Date of Publication
c2009
Series Title
Allergy Frontiers
ISBN
9784431728023
Subjects (MeSH)
Hypersensitivity - epidemiology
Hypersensitivity - genetics
Allergens
Subjects (LCSH)
Allergy
Format
e-Book
Location
Online
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Asbestos and Mesothelioma

https://libcat.nshealth.ca/en/permalink/provcat41725
Joseph R. Testa, editor. --Cham: Springer , 2017.
Available Online
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Location
Online
This volume is comprised of a multidisciplinary assessment of the interplay between asbestos and cancer as well as new research about the biology and treatment of malignant mesothelioma. Chapters on the various types of asbestos and other mineral fibers, epidemiology, history and future of asbestos-related diseases are included. Other reviews present new information about the role of asbestos-related inflammation and genetic factors, including the role of inherited mutations of BAP1, in mesothe…
Available Online
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Other Authors
Testa, Joseph R.
Responsibility
Joseph R. Testa, editor
Place of Publication
Cham
Publisher
Springer
Date of Publication
2017
Physical Description
1 online resource (viii, 407 pages) : 65 illus., 43 illus. in color
Series Title
Current cancer research
ISBN
9783319535609
9783319535586 (print ed.)
ISSN
2199-2584
Subjects (MeSH)
Asbestos - adverse effects
Mesothelioma - etiology
Mesothelioma - genetics
Mesothelioma - therapy
Abstract
This volume is comprised of a multidisciplinary assessment of the interplay between asbestos and cancer as well as new research about the biology and treatment of malignant mesothelioma. Chapters on the various types of asbestos and other mineral fibers, epidemiology, history and future of asbestos-related diseases are included. Other reviews present new information about the role of asbestos-related inflammation and genetic factors, including the role of inherited mutations of BAP1, in mesothelioma causation, as well as recent research about gene signatures, cell signaling, and epigenetic mechanisms in asbestos-related diseases. Other chapters provide updates of novel disease biomarkers and prevention, mechanistic lesson from genetically engineered mouse and 3-D models of mesothelioma tumorigenesis and therapeutic resistance. Also included are up-to-date reviews of surgical, molecularly targeted chemotherapeutic, and immunotherapeutic approaches for mesothelioma as well as an overview of legal issues.
Contents
1. Malignant Mesothelioma: An Asbestos Legacy -- 2. Asbestos and Fibrous Erionite -- 3. Epidemiology of Mesothelioma -- 4. Malignant Pleural Mesothelioma: History, Controversy and Future of a Man-Made Epidemic -- 5. Communities at High Risk in the Third Wave of Mesothelioma -- 6. Mesothelioma Pathology -- 7. Asbestos-Induced Inflammation in Malignant Mesothelioma and Other Lung Diseases -- 8. Germline and Somatic Mutations in Human Mesothelioma and Lessons from Asbestos-Exposed Genetically Engineered Mouse Models -- 9. Gene Signature of Malignant Pleural Mesothelioma -- 10. Cell Signaling and Epigenetic Mechanisms in Mesothelioma -- 11. 3D Models of Mesothelioma in the Study of Mechanisms of Cell Survival -- 12. Biomarkers of Response to Asbestos Exposure -- 13. Surgery Approaches in Mesothelioma -- 14. Radiotherapy and Photodynamic Therapy for Malignant Pleural Mesothelioma -- 15. Standard Chemotherapy Options and Clinical Trials of Novel Agents for Mesothelioma -- 16. Immunotherapeutic Approaches to Mesothelioma -- 17. Challenges Facing Mesothelioma Patients and Their Families: Medical/Legal Intersections -- 18. The Patient's Experience of Malignant Mesothelioma.
Format
e-Book
Location
Online
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Atlas of Genetic Diagnosis and Counseling

https://libcat.nshealth.ca/en/permalink/provcat30009
by Harold Chen. --Totowa, NJ: Humana Press , c2006.
Available Online
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Location
Online
Available Online
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Author
Chen, Harold
Responsibility
by Harold Chen
Place of Publication
Totowa, NJ
Publisher
Humana Press
Date of Publication
c2006
ISBN
9781603271615
Subjects (MeSH)
Genetic counseling
Genetic Diseases, Inborn - Encyclopedias
Prenatal Diagnosis
Subjects (LCSH)
Genetics
Reproductive medicine
Format
e-Book
Location
Online
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Bacterial Genomes and Infectious Diseases

https://libcat.nshealth.ca/en/permalink/provcat30077
edited by Voon L. Chan, Philip M. Sherman, Billy Bourke. --Totowa, NJ: Humana Press , c2006.
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Location
Online
Available Online
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Author
Chan, Voon L
Other Authors
Sherman, Philip M
Bourke, Billy
Responsibility
edited by Voon L. Chan, Philip M. Sherman, Billy Bourke
Place of Publication
Totowa, NJ
Publisher
Humana Press
Date of Publication
c2006
ISBN
9781597451529
Subjects (MeSH)
Communicable Diseases - genetics
Bacteria - genetics
Virulence - genetics
Subjects (LCSH)
Infectious diseases
Microbiology
Genetics
Format
e-Book
Location
Online
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Bacterial genomes and infectious diseases

https://libcat.nshealth.ca/en/permalink/provcat22867
Chan, Voon L. --Totowa, NJ: Humana Press , 2006.
Call Number
QW 51 B131 2006
Location
Dickson Building
Call Number
QW 51 B131 2006
Author
Chan, Voon L
Other Authors
Sherman, Philip M
Bourke, Billy
Place of Publication
Totowa, NJ
Publisher
Humana Press
Date of Publication
2006
Physical Description
270 p.
ISBN
158829496X
Subjects (MeSH)
Bacteria - genetics
Communicable Diseases - genetics
Virulence - genetics
Format
Book
Location
Dickson Building
Loan Period
3 weeks
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Basic and clinical science course. Section 2, Fundamentals and principles of ophthalmology

https://libcat.nshealth.ca/en/permalink/provcat24628
American Academy of Ophthalmology. (2009-2010) --San Francisco, CA: American Academy of Ophthalmology , 2009.
Call Number
WW 100 B311 v.2
Location
Dickson Building
Call Number
WW 100 B311 v.2
Corporate Author
American Academy of Ophthalmology
Edition
2009-2010
Place of Publication
San Francisco, CA
Publisher
American Academy of Ophthalmology
Date of Publication
2009
Physical Description
455 p.
Series Vol.
section 2
Series Title
Basic and clinical science course
Lifelong education for the ophthalmologist
ISBN
9781560559665
9781560559955 (set)
Subjects (MeSH)
Eye
Vision
Eye diseases - genetics
Eye Diseases - drug therapy
Format
Book
Location
Dickson Building
Loan Period
3 weeks
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Basic Concepts of Molecular Pathology

https://libcat.nshealth.ca/en/permalink/provcat28227
edited by Timothy Craig Allen, Philip T. Cagle. --Boston, MA: Springer US , c2009.
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Location
Online
Available Online
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Author
Allen, Timothy Craig
Other Authors
Cagle, Philip T
Responsibility
edited by Timothy Craig Allen, Philip T. Cagle
Place of Publication
Boston, MA
Publisher
Springer US
Date of Publication
c2009
Series Vol.
v. 2
Series Title
Molecular pathology library
ISBN
9780387896267
Subjects (MeSH)
Molecular Biology - methods
Pathology, Clinical - methods
Clinical Laboratory Techniques
Subjects (LCSH)
Pathology
Genetics
Biochemistry
Format
e-Book
Location
Online
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Birth Defects in India

https://libcat.nshealth.ca/en/permalink/provcat46965
Anita Kar. Springer , 2021.
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Location
Online
Available Online
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Responsibility
Anita Kar
Publisher
Springer
Date of Publication
2021
Physical Description
1 online resource (xxix, 362 pages) : illustrations
ISBN
9789811615542
Other Subjects
India
Specialty
Genetics, Medical
Public Health
Format
e-Book
Location
Online
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BRAF Targets in Melanoma : Biological Mechanisms, Resistance, and Drug Discovery

https://libcat.nshealth.ca/en/permalink/provcat39005
Ryan J. Sullivan, editor. --New York, NY: Springer , c2015.
Available Online
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Location
Online
This volume contains a collection of writings from the leaders in the fields of Molecular Biology and Melanoma Research which will begin to tell the ever-expanding story of the most recent findings, discoveries, and potential of BRAF-directed targets in melanoma. Recent research has shown that BRAF inhibitors are effective for a short period of time, but there is little hope that these drugs as single agents will lead to durable benefit in a majority of patients. Among scientists and researcher…
Available Online
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Other Authors
Sullivan, Ryan J
Responsibility
Ryan J. Sullivan, editor
Place of Publication
New York, NY
Publisher
Springer
Date of Publication
c2015
Physical Description
1 online resource (viii, 204 p. : 26 illus., 21 illus. in color)
Series Vol.
82
Series Title
Cancer drug discovery and development
ISBN
9781493921430
9781493921423 (print ed.)
ISSN
2196-9906
Subjects (MeSH)
Melanoma - drug therapy
Melanoma - genetics
Molecular Targeted Therapy - methods
Protein Kinase Inhibitors - therapeutic use
Proto-Oncogene Proteins B-raf - antagonists & inhibitors
Abstract
This volume contains a collection of writings from the leaders in the fields of Molecular Biology and Melanoma Research which will begin to tell the ever-expanding story of the most recent findings, discoveries, and potential of BRAF-directed targets in melanoma. Recent research has shown that BRAF inhibitors are effective for a short period of time, but there is little hope that these drugs as single agents will lead to durable benefit in a majority of patients. Among scientists and researchers who work in drug discovery, there is a lot of interest in the development of molecularly targeted cancer agents. Namely, the identification of a molecular target, the selection of molecules which effectively inhibit this target. What is starkly different about the development of this class of compounds, however, is that the mechanism of action of these agents are not as straightforward as was once previously assumed and the mechanisms of resistance that tumor cells employ to evade complete destruction are unlike any that have been described before. These discoveries in addition to utilization of modern molecular biology techniques have led to a series of hypotheses regarding which other types of molecules could be used in combination with BRAF-inhibitors in hopes of revolutionizing the potential of therapeutics in melanoma.
Contents
1. Melanoma: Historical Context -- 2. Melanoma Pathogenesis -- 3. Molecular Diagnostics and Tumor Mutational Analysis -- 4. Clinical Utility of BRAF-Targeted Therapy in Melanoma -- 5. The Ethics of Randomized Trials in Oncology -- 6. Parallel and Serial Blockade Strategies in BRAF-Mutant Melanoma -- 7. Targeting the Cell Cycle and p53 in Combination with BRAF-Directed Therapy -- 8. Combination BRAF-Directed Therapy and Immunotherapy -- 9. Moving Forward: Making BRAF-Targeted Therapy Better.
Format
e-Book
Location
Online
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Breast Cancer Biology for the Radiation Oncologist

https://libcat.nshealth.ca/en/permalink/provcat39392
Jonathan Strauss, William Small, Gayle E. Woloschak, editors. --Berlin, Heidelberg: Springer , c2015.
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Location
Online
Breast Cancer Biology for the Radiation Oncologist is the first textbook of its kind devoted to describing the biological complexities of breast cancer in a way that is relevant to the radiation oncologist. Radiation Oncology has long treated breast cancer as a single biological entity, with all treatment decisions being based on clinical and pathologic risk factors. We are now beginning to understand that biological subtypes of breast cancer may have different risks of recurrence as well as di…
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Other Authors
Strauss, Jonathan
Small, William
Woloschak, Gayle E
Responsibility
Jonathan Strauss, William Small, Gayle E. Woloschak, editors
Place of Publication
Berlin, Heidelberg
Publisher
Springer
Date of Publication
c2015
Physical Description
1 online resource (vii, 90 p. : 15 illus., 5 illus. in color)
Series
Medical radiology. Radiation oncology
Series Title
Medical radiology (Series)
ISBN
9783642312205
9783642312199 (print ed.)
ISSN
0942-5373
Subjects (MeSH)
Breast neoplasms - genetics
Breast Neoplasms - physiopathology
Breast neoplasms - radiotherapy
Abstract
Breast Cancer Biology for the Radiation Oncologist is the first textbook of its kind devoted to describing the biological complexities of breast cancer in a way that is relevant to the radiation oncologist. Radiation Oncology has long treated breast cancer as a single biological entity, with all treatment decisions being based on clinical and pathologic risk factors. We are now beginning to understand that biological subtypes of breast cancer may have different risks of recurrence as well as different intrinsic sensitivity to radiotherapy. Multi-gene arrays that have for years been used to predict the risk of distant recurrence and the value of systemic chemotherapy may also have utility in predicting the risk of local recurrence. Additionally, the targeted agents used to treat breast cancer may interact with radiotherapy in ways that can be beneficial or undesirable. All of these emerging issues of central importance to radiation oncologists are extensively discussed in this book, and practical treatment recommendations based on available clinical evidence are presented whenever possible.
Contents
Biological subtypes of breast cancer -- Oncogene amplification and Herceptin -- Current clinical use of genetic profiling -- Biology of DCIS and progression to invasive disease -- Cancer Stem Cells and Radiotherapy -- Genetic basis of normal tissue radiosensitivity and late toxicity -- Genetic syndromes and radiotherapy in breast cancer -- Experimental therapies in breast cancer.
Format
e-Book
Location
Online
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edited by Boris Pasche. --Boston, MA: Springer Science+Business Media , c2010.
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Location
Online
Available Online
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Author
Pasche, Boris
Responsibility
edited by Boris Pasche
Place of Publication
Boston, MA
Publisher
Springer Science+Business Media
Date of Publication
c2010
Series Vol.
155
Series Title
Cancer treatment and research
ISBN
9781441960337
Subjects (MeSH)
Neoplasms - genetics
Subjects (LCSH)
Oncology
Genetics
Format
e-Book
Location
Online
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Elsevier
Available Online
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Holdings
Vol 204, 2011 -
Location
Online
Available Online
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Publisher
Elsevier
Holdings
Vol 204, 2011 -
Publication Frequency
Monthly
ISSN
2210-7762
Specialty
Genetics, Medical
Medical Oncology
Format
e-Journal
Location
Online
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Cancer genetics and cytogenetics

https://libcat.nshealth.ca/en/permalink/provcat19467
Elsevier
Available Online
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Holdings
Vol 172, 2007 -
Location
Online
Available Online
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Publisher
Elsevier
Holdings
Vol 172, 2007 -
Publication Frequency
Irregular
ISSN
0165-4608
Specialty
Genetics, Medical
Medical Oncology
Format
e-Journal
Location
Online
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267 records – page 1 of 14.