ABC of clinical genetics
https://libcat.nshealth.ca/en/permalink/provcat52752
[by] Helen M. Kingston.
(3rd ed.)
--London, England:
BMJ Books
, 2002.
- Call Number
- QZ 50 K55 2002
- Location
- IWK Health Sciences Library
- Call Number
- QZ 50 K55 2002
- Author
- Kingston, Helen
- Responsibility
- [by] Helen M. Kingston
- Edition
- 3rd ed.
- Place of Publication
- London, England
- Publisher
- BMJ Books
- Date of Publication
- 2002
- Physical Description
- 120 p.
- ISBN
- 727916270
- Subjects (MeSH)
- Genetics, Medical
- Format
- Book
- Location
- IWK Health Sciences Library
- Copies
- 1
- Loan Period
- 2 weeks
Abnormal Skeletal Phenotypes : From Simple Signs to Complex Diagnoses
https://libcat.nshealth.ca/en/permalink/provcat29247
by Alessandro Castriota-Scanderbeg, Bruno Dallapiccola.
--Berlin, Heidelberg:
Springer-Verlag
, c2005.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Other Authors
- Dallapiccola, Bruno
- Responsibility
- by Alessandro Castriota-Scanderbeg, Bruno Dallapiccola
- Place of Publication
- Berlin, Heidelberg
- Publisher
- Springer-Verlag
- Date of Publication
- c2005
- ISBN
- 9783540303619
- Subjects (MeSH)
- Abnormalities, Multiple - diagnosis
- Abnormalities, Multiple - diagnostic imaging
- Bone Diseases - genetics
- Bone and Bones - diagnostic imaging
- Bone and Bones - abnormalities
- Phenotype
- Radiography
- Subjects (LCSH)
- Genetics
- Orthopedics
- Radiology Medical
- Format
- e-Book
- Location
- Online
Acute Exacerbation of Chronic Hepatitis B : Volume 1. Definition, Research Technology, Virology, Genetics and Immunology
https://libcat.nshealth.ca/en/permalink/provcat44504
Qin Ning, editor.
--Dordrecht:
Springer
, c2019.
- Available Online
- View e-Book
- Location
- Online
This book assembles recent achievements in both basic research and clinical management in the field of hepatology, virology and immunology. It provides up-to-date information for clinicians who can apply the relevant knowledge to their daily clinical practice and for researchers who are interested in clinically orientated studies. The updated and detailed technology, state-of–the-art treatment strategies provided in this book serve as references for clinicians and resident physicians in the dai…
- Available Online
- View e-Book
- Other Authors
- Ning, Qin
- Responsibility
- Qin Ning, editor
- Place of Publication
- Dordrecht
- Publisher
- Springer
- Date of Publication
- c2019
- Physical Description
- 1 online resource (xxiii, 369 p.) : 55 illus., 44 illus. in color
- ISBN
- 9789402416060
- 9789402416046 (Print ed.)
- 9789402416053 (Print ed.)
- Subjects (MeSH)
- Disease Progression
- Hepatitis B, Chronic - genetics
- Hepatitis B, Chronic - immunology
- Hepatitis B, Chronic - virology
- Specialty
- Gastroenterology
- Virology
- Abstract
- This book assembles recent achievements in both basic research and clinical management in the field of hepatology, virology and immunology. It provides up-to-date information for clinicians who can apply the relevant knowledge to their daily clinical practice and for researchers who are interested in clinically orientated studies. The updated and detailed technology, state-of–the-art treatment strategies provided in this book serve as references for clinicians and resident physicians in the daily management of ACLF. The rationality and strategies for basic research as well as patient management in this book can also be a valuable reference for other fatal and end stage liver diseases than HBV induced ACLF. This volume 1 has 6 chapters and focuses on the definition, research technology, virology, genetics, and immunology.
- Contents
- 1. Introduction to Acute Exacerbation of Chronic Hepatitis B (AECHB) -- 2. Research Methods and Techniques for Acute Exacerbation of Chronic Hepatitis B -- 3. Virological Factors Involved in AECHB -- 4. Host Genetic Characters of Acute Exacerbation of Chronic Hepatitis B (AECHB) -- 5. Immunological Features of AECHB -- 6. Other Precipitating Factors for AECHB.
- Format
- e-Book
- Location
- Online
Acute myelogenous leukemia : genetics, biology and therapy
https://libcat.nshealth.ca/en/permalink/provcat30141
- Available Online
- View e-Book
- Other Authors
- Nagarajan, Lalitha
- Place of Publication
- New York, NY
- Publisher
- Springer-Verlag
- Date of Publication
- c2010
- Series Vol.
- 145
- Series Title
- Cancer treatment and research
- ISBN
- 9780387692593
- Subjects (LCSH)
- Hematology
- Oncology
- Format
- e-Book
- Location
- Online
Advances in DNA repair in cancer therapy
https://libcat.nshealth.ca/en/permalink/provcat32399
Lawrence Panasci, Raquel Aloyz, Moulay Alaoui-Jamali, editors.
--New York, NY:
Springer
, c2013.
- Available Online
- View e-Book
- Location
- Online
This book deals with the emerging role of various DNA repair proteins and the regulatory elements which are implicated in cancer therapy such as DNA cross-linking agents, radiotherapy and bleomycin. The DNA repair genes discussed include those involved in BRCA/Rad51-related homologous recombinational repair, DNA-PK related nonhomologous endjoining and the nucleotide excision repair gene, ERCC1. Moreover, the role of regulatory genes such as PARP, ATR, telomerase, growth factor receptors and dow…
- Available Online
- View e-Book
- Other Authors
- Panasci, Lawrence
- Aloyz, Raquel
- Alaoui-Jamali, Moulay
- Responsibility
- Lawrence Panasci, Raquel Aloyz, Moulay Alaoui-Jamali, editors
- Place of Publication
- New York, NY
- Publisher
- Springer
- Date of Publication
- c2013
- Physical Description
- 1 online resource (viii, 312 p. : 35 ill., 25 ill. in color)
- Series Vol.
- 72
- Series Title
- Cancer drug discovery and development
- ISBN
- 9781461447412
- Subjects (MeSH)
- Antineoplastic Agents - therapeutic use
- DNA Repair
- Neoplasms - drug therapy
- Neoplasms - genetics
- Subjects (LCSH)
- Oncology
- Abstract
- This book deals with the emerging role of various DNA repair proteins and the regulatory elements which are implicated in cancer therapy such as DNA cross-linking agents, radiotherapy and bleomycin. The DNA repair genes discussed include those involved in BRCA/Rad51-related homologous recombinational repair, DNA-PK related nonhomologous endjoining and the nucleotide excision repair gene, ERCC1. Moreover, the role of regulatory genes such as PARP, ATR, telomerase, growth factor receptors and downstream kinase signalling is examined.
- Contents
- Repair of DNA interstrand cross-links produced by cancer chemotherapeutic drugs -- DNA-PK, a pharmacological target in cancer chemotherapy and radiotherapy -- Growth factor receptor signaling, DNA damage response, and cancer cell susceptibility to chemotherapy and relapses -- Relationship between DNA-repair genes, cellular radiosensitivity, and the response of tumors annd normal tissues to radiotherapy -- Important roles of ERCCI in DNA repair and targeted therapy -- The role of BRCA1 and BRCA2 in anticancer drug therepy -- DNA-PK in CLL chemotherapy -- Poly (ADP) ribose polymerase at the interface of DNA damage signaling and DNA repair -- Cellular protection against the antitumor drug bleomycin -- ATR as a therapeutic target -- Telomores, Telomerase, and DNA damage response in cancer therapy -- RAD51 is a key protein of DNA repair and homologous recombination in humans -- Index.
- Format
- e-Book
- Location
- Online
Advances in Vision Research. Volume I, Genetic Eye Research in Asia and the Pacific
https://libcat.nshealth.ca/en/permalink/provcat41924
Gyan Prakash, Takeshi Iwata, editors.
--Tokyo:
Springer
, 2017.
- Available Online
- View e-Book
- Location
- Online
This book presents the state of the art in genetic eye research in Asia and the Pacific. Though there has been an explosion of information on genetic eye research in western countries, more than sixty percent of the human genes involved in eye diseases in the Asian and Pacific population remain unknown. However, new efforts and a new awareness have sparked important discussions on the subject, and new plans are being implemented to discover the genes responsible for many eye diseases in the pop…
- Available Online
- View e-Book
- Other Authors
- Prakash, Gyan
- Iwata, Takeshi
- Responsibility
- Gyan Prakash, Takeshi Iwata, editors
- Alternate Title
- Genetic Eye Research in Asia and the Pacific
- Place of Publication
- Tokyo
- Publisher
- Springer
- Date of Publication
- 2017
- Physical Description
- 1 online resource (xv, 523 pages) : 71 illus., 55 illus. in color
- Series Title
- Essentials in ophthalmology
- ISBN
- 9784431565116
- 9784431565093 (print ed.)
- ISSN
- 1612-3212
- Subjects (MeSH)
- Eye diseases - genetics
- Biomedical Research
- Other Subjects
- Asia
- Abstract
- This book presents the state of the art in genetic eye research in Asia and the Pacific. Though there has been an explosion of information on genetic eye research in western countries, more than sixty percent of the human genes involved in eye diseases in the Asian and Pacific population remain unknown. However, new efforts and a new awareness have sparked important discussions on the subject, and new plans are being implemented to discover the genes responsible for many eye diseases in the population. The book reviews the latest findings; its content ranges from genetic aspects of human migration to DNA sequence analysis, genome-wide association analysis, and disease phenotypes. The efforts of the Asian Eye Genetic Consortium (AEGC) are also discussed. The book's editors have been instrumental in developing strategies for discovering the new Asian genes involved in many eye diseases. All chapters were written by leading researchers working on Asian eye genetics from the fields of Human Genetics, Ophthalmology, Molecular Biology, Biochemistry, Sensory Sciences, and Clinical Research. Advances in Vision Research, Volume I will prove to be a major resource for all researchers, clinicians, clinical researchers, and allied eye health professionals with an interest in eye diseases among the Asian population.
- Contents
- 1. Foundation of Asian Eye Genetics Consortium (AEGC) -- 2. Japan consortium for whole exome analysis of hereditary retinal diseases -- 3. Whole-genome sequencing in genetic eye diseases in China -- 4. Targeted exome sequencing in Japanese patients with Retinitis Pigmentosa -- 5. Genetic Epidemiology of Congenital Cataracts and Autosomal Recessive Retinal Degenerations in Pakistan -- 6. Genetics of Cataract in Asia -- 7. Genetic analysis of families with retinal dystrophies -- 8. Whole genome sequencing in patients with Retinitis Pigmentosa -- 9. Retinitis pigmentosa in Korean patients -- 10. Retinitis pigmentosa in Chinese population -- 11. Retinitis Pigmentosa in Japanese Population -- 12. Cone Dysfunction Syndrome in Japanese Population -- 13. Leber Congenital Amaurosis/Early-Onset Retinal Dystrophy in Japanese Population -- 14. Paradigm of Susceptibility genes in AMD and PCV -- 15. Genetics and Pathology of Inflammatory Components on AMD -- 16. Genome wide association study of age-related eye diseases in Chinese population -- 17. Clinical Genetics of Retinoblastoma: An Asian Perspective -- 18. Molecular and Clinical Genetics of Retinoblastoma -- 19. Current research Perspectives in Understanding Diabetic Retinopathy -- 20. Genome-wide association studies of glaucoma -- 21. Genetic Complexity of Primary Angle Closure Glaucoma in Asians -- 22. Genotype-phenotype correlation for POAG in the Middle East Khaled Abu-Amero (Saudi Arabia), Alta-- 23. Corneal Dystrophies in India -- 24. Genetics of Corneal Endothelial Dystrophies: An Asian Perspective -- 25. Keratoconus in Asia -- 26. Genetics of Pediatric Eye Diseases and Strabismus in Asia -- 27. Keratoconus: Globally and in the Middle East; Epidemiology, Genetics and future Research -- 28. Genetics of Myopia -- 29. Ocular Implications of Gaucher Disease -- 30. Genetic background of Uveitis in Chinese population -- 31. Usher Syndrome in Chinese and Japanese Population -- 32. Homozygosity Mapping for Autosomal Recessive Ocular Diseases -- 33. Tools of Genetic Eye Research and Need for Clinical Research Collaborations -- 34. Eye Genetics: The Road Ahead to Quality Standards -- 35. Genetic Counselling in Asia -- 36. Epigenetic study in Asian Eye Diseases -- 37. Unique Asian Patients Population: An Opportunity for Drug Development -- 38. A Perspective: How can gene therapeutics help address ophthalmic health issues in Asia?
- Format
- e-Book
- Location
- Online
Aging and the heart : A Post-Genomic View
https://libcat.nshealth.ca/en/permalink/provcat28046
by José MarÃn-GarcÃa, Michael J. Goldenthal, Gordon W. Moe.
--Boston, MA:
Springer Science+Business Media
, c2008.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Author
- MarÃn-GarcÃa, José
- Other Authors
- Goldenthal, Michael J
- Moe, Gordon W
- Responsibility
- by José Marín-García, Michael J. Goldenthal, Gordon W. Moe
- Place of Publication
- Boston, MA
- Publisher
- Springer Science+Business Media
- Date of Publication
- c2008
- ISBN
- 9780387740720
- Subjects (MeSH)
- Aging - physiology
- Cardiovascular Diseases - genetics
- Cardiovascular Diseases - physiopathology
- Subjects (LCSH)
- Cardiology
- Geriatrics
- Format
- e-Book
- Location
- Online
Allergy frontiers. Vol. 1, Epigenetics, allergens and risk factors
https://libcat.nshealth.ca/en/permalink/provcat29105
- Available Online
- View e-Book
- Other Authors
- Pawankar, Ruby
- Holgate, Stephen T
- Rosenwasser, Lanny J
- Place of Publication
- Tokyo
- Publisher
- Springer Japan
- Date of Publication
- c2009
- Series Title
- Allergy Frontiers
- ISBN
- 9784431728023
- Subjects (MeSH)
- Hypersensitivity - epidemiology
- Hypersensitivity - genetics
- Allergens
- Subjects (LCSH)
- Allergy
- Format
- e-Book
- Location
- Online
Asbestos and Mesothelioma
https://libcat.nshealth.ca/en/permalink/provcat41725
Joseph R. Testa, editor.
--Cham:
Springer
, 2017.
- Available Online
- View e-Book
- Location
- Online
This volume is comprised of a multidisciplinary assessment of the interplay between asbestos and cancer as well as new research about the biology and treatment of malignant mesothelioma. Chapters on the various types of asbestos and other mineral fibers, epidemiology, history and future of asbestos-related diseases are included. Other reviews present new information about the role of asbestos-related inflammation and genetic factors, including the role of inherited mutations of BAP1, in mesothe…
- Available Online
- View e-Book
- Other Authors
- Testa, Joseph R.
- Responsibility
- Joseph R. Testa, editor
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- 2017
- Physical Description
- 1 online resource (viii, 407 pages) : 65 illus., 43 illus. in color
- Series Title
- Current cancer research
- ISBN
- 9783319535609
- 9783319535586 (print ed.)
- ISSN
- 2199-2584
- Subjects (MeSH)
- Asbestos - adverse effects
- Mesothelioma - etiology
- Mesothelioma - genetics
- Mesothelioma - therapy
- Abstract
- This volume is comprised of a multidisciplinary assessment of the interplay between asbestos and cancer as well as new research about the biology and treatment of malignant mesothelioma. Chapters on the various types of asbestos and other mineral fibers, epidemiology, history and future of asbestos-related diseases are included. Other reviews present new information about the role of asbestos-related inflammation and genetic factors, including the role of inherited mutations of BAP1, in mesothelioma causation, as well as recent research about gene signatures, cell signaling, and epigenetic mechanisms in asbestos-related diseases. Other chapters provide updates of novel disease biomarkers and prevention, mechanistic lesson from genetically engineered mouse and 3-D models of mesothelioma tumorigenesis and therapeutic resistance. Also included are up-to-date reviews of surgical, molecularly targeted chemotherapeutic, and immunotherapeutic approaches for mesothelioma as well as an overview of legal issues.
- Contents
- 1. Malignant Mesothelioma: An Asbestos Legacy -- 2. Asbestos and Fibrous Erionite -- 3. Epidemiology of Mesothelioma -- 4. Malignant Pleural Mesothelioma: History, Controversy and Future of a Man-Made Epidemic -- 5. Communities at High Risk in the Third Wave of Mesothelioma -- 6. Mesothelioma Pathology -- 7. Asbestos-Induced Inflammation in Malignant Mesothelioma and Other Lung Diseases -- 8. Germline and Somatic Mutations in Human Mesothelioma and Lessons from Asbestos-Exposed Genetically Engineered Mouse Models -- 9. Gene Signature of Malignant Pleural Mesothelioma -- 10. Cell Signaling and Epigenetic Mechanisms in Mesothelioma -- 11. 3D Models of Mesothelioma in the Study of Mechanisms of Cell Survival -- 12. Biomarkers of Response to Asbestos Exposure -- 13. Surgery Approaches in Mesothelioma -- 14. Radiotherapy and Photodynamic Therapy for Malignant Pleural Mesothelioma -- 15. Standard Chemotherapy Options and Clinical Trials of Novel Agents for Mesothelioma -- 16. Immunotherapeutic Approaches to Mesothelioma -- 17. Challenges Facing Mesothelioma Patients and Their Families: Medical/Legal Intersections -- 18. The Patient's Experience of Malignant Mesothelioma.
- Format
- e-Book
- Location
- Online
Atlas of Genetic Diagnosis and Counseling
https://libcat.nshealth.ca/en/permalink/provcat30009
by Harold Chen.
--Totowa, NJ:
Humana Press
, c2006.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Author
- Chen, Harold
- Responsibility
- by Harold Chen
- Place of Publication
- Totowa, NJ
- Publisher
- Humana Press
- Date of Publication
- c2006
- ISBN
- 9781603271615
- Subjects (LCSH)
- Genetics
- Reproductive medicine
- Format
- e-Book
- Location
- Online
Bacterial Genomes and Infectious Diseases
https://libcat.nshealth.ca/en/permalink/provcat30077
edited by Voon L. Chan, Philip M. Sherman, Billy Bourke.
--Totowa, NJ:
Humana Press
, c2006.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Author
- Chan, Voon L
- Other Authors
- Sherman, Philip M
- Bourke, Billy
- Responsibility
- edited by Voon L. Chan, Philip M. Sherman, Billy Bourke
- Place of Publication
- Totowa, NJ
- Publisher
- Humana Press
- Date of Publication
- c2006
- ISBN
- 9781597451529
- Subjects (MeSH)
- Communicable Diseases - genetics
- Bacteria - genetics
- Virulence - genetics
- Subjects (LCSH)
- Infectious diseases
- Microbiology
- Genetics
- Format
- e-Book
- Location
- Online
Bacterial genomes and infectious diseases
https://libcat.nshealth.ca/en/permalink/provcat22867
Chan, Voon L.
--Totowa, NJ:
Humana Press
, 2006.
- Call Number
- QW 51 B131 2006
- Location
- Dickson Building
- Call Number
- QW 51 B131 2006
- Author
- Chan, Voon L
- Other Authors
- Sherman, Philip M
- Bourke, Billy
- Place of Publication
- Totowa, NJ
- Publisher
- Humana Press
- Date of Publication
- 2006
- Physical Description
- 270 p.
- ISBN
- 158829496X
- Subjects (MeSH)
- Bacteria - genetics
- Communicable Diseases - genetics
- Virulence - genetics
- Format
- Book
- Location
- Dickson Building
- Loan Period
- 3 weeks
Basic and clinical science course. Section 2, Fundamentals and principles of ophthalmology
https://libcat.nshealth.ca/en/permalink/provcat24628
American Academy of Ophthalmology.
(2009-2010)
--San Francisco, CA:
American Academy of Ophthalmology
, 2009.
- Call Number
- WW 100 B311 v.2
- Location
- Dickson Building
- Call Number
- WW 100 B311 v.2
- Corporate Author
- American Academy of Ophthalmology
- Edition
- 2009-2010
- Place of Publication
- San Francisco, CA
- Publisher
- American Academy of Ophthalmology
- Date of Publication
- 2009
- Physical Description
- 455 p.
- Series Vol.
- section 2
- ISBN
- 9781560559665
- 9781560559955 (set)
- Subjects (MeSH)
- Eye
- Vision
- Eye diseases - genetics
- Eye Diseases - drug therapy
- Format
- Book
- Location
- Dickson Building
- Loan Period
- 3 weeks
Basic Concepts of Molecular Pathology
https://libcat.nshealth.ca/en/permalink/provcat28227
edited by Timothy Craig Allen, Philip T. Cagle.
--Boston, MA:
Springer US
, c2009.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Author
- Allen, Timothy Craig
- Other Authors
- Cagle, Philip T
- Responsibility
- edited by Timothy Craig Allen, Philip T. Cagle
- Place of Publication
- Boston, MA
- Publisher
- Springer US
- Date of Publication
- c2009
- Series Vol.
- v. 2
- Series Title
- Molecular pathology library
- ISBN
- 9780387896267
- Subjects (MeSH)
- Molecular Biology - methods
- Pathology, Clinical - methods
- Clinical Laboratory Techniques
- Subjects (LCSH)
- Pathology
- Genetics
- Biochemistry
- Format
- e-Book
- Location
- Online
Birth Defects in India
https://libcat.nshealth.ca/en/permalink/provcat46965
- Available Online
- View e-Book
- Responsibility
- Anita Kar
- Publisher
- Springer
- Date of Publication
- 2021
- Physical Description
- 1 online resource (xxix, 362 pages) : illustrations
- ISBN
- 9789811615542
- Other Subjects
- India
- Specialty
- Genetics, Medical
- Public Health
- Format
- e-Book
- Location
- Online
Botulinum Toxins
https://libcat.nshealth.ca/en/permalink/chpams37718
IWK. Cerebral Palsy Clinic, IWK. Neurosurgery Clinic, IWK. Medical, Surgical and Neurosciences Unit (MSNU).
Halifax, NS:
IWK Health Centre
, 2022.
- Pamphlet Number
- PL-0326
- Available Online
- View Pamphlet
Botox administration.
- Available Online
- View Pamphlet
- Corporate Author
- IWK. Cerebral Palsy Clinic
- IWK. Neurosurgery Clinic
- IWK. Medical, Surgical and Neurosciences Unit (MSNU)
- Alternate Title
- A Guide for Families
- Place of Publication
- Halifax, NS
- Publisher
- IWK Health Centre
- Date of Publication
- 2022
- Format
- Pamphlet
- Language
- English
- Physical Description
- 1 electronic document : digital, PDF file
- Subjects (MeSH)
- Heredity
- Congenital Abnormalities
- Child Health
- Surgical Procedures, Operative
- Therapeutics
- Diagnostic Techniques and Procedures
- Genetics, Medical
- Musculoskeletal system
- Subjects (LCSH)
- Therapeutics
- Surgery, Operative
- Orthopedics
- Human genetics
- Genetics
- Diagnosis
- Abnormalities, Human
- Children--Health and hygiene
- Abstract
- Botox administration.
- Notes
- Formerly titled "Botox (Botulinum Toxin Type A): A Guide for Parents".
- Responsibility
- IWK Cerebral Palsy Clinic, Halifax, NS
- Pamphlet Number
- PL-0326
BRAF Targets in Melanoma : Biological Mechanisms, Resistance, and Drug Discovery
https://libcat.nshealth.ca/en/permalink/provcat39005
Ryan J. Sullivan, editor.
--New York, NY:
Springer
, c2015.
- Available Online
- View e-Book
- Location
- Online
This volume contains a collection of writings from the leaders in the fields of Molecular Biology and Melanoma Research which will begin to tell the ever-expanding story of the most recent findings, discoveries, and potential of BRAF-directed targets in melanoma. Recent research has shown that BRAF inhibitors are effective for a short period of time, but there is little hope that these drugs as single agents will lead to durable benefit in a majority of patients. Among scientists and researcher…
- Available Online
- View e-Book
- Other Authors
- Sullivan, Ryan J
- Responsibility
- Ryan J. Sullivan, editor
- Place of Publication
- New York, NY
- Publisher
- Springer
- Date of Publication
- c2015
- Physical Description
- 1 online resource (viii, 204 p. : 26 illus., 21 illus. in color)
- Series Vol.
- 82
- Series Title
- Cancer drug discovery and development
- ISBN
- 9781493921430
- 9781493921423 (print ed.)
- ISSN
- 2196-9906
- Subjects (MeSH)
- Melanoma - drug therapy
- Melanoma - genetics
- Molecular Targeted Therapy - methods
- Protein Kinase Inhibitors - therapeutic use
- Proto-Oncogene Proteins B-raf - antagonists & inhibitors
- Abstract
- This volume contains a collection of writings from the leaders in the fields of Molecular Biology and Melanoma Research which will begin to tell the ever-expanding story of the most recent findings, discoveries, and potential of BRAF-directed targets in melanoma. Recent research has shown that BRAF inhibitors are effective for a short period of time, but there is little hope that these drugs as single agents will lead to durable benefit in a majority of patients. Among scientists and researchers who work in drug discovery, there is a lot of interest in the development of molecularly targeted cancer agents. Namely, the identification of a molecular target, the selection of molecules which effectively inhibit this target. What is starkly different about the development of this class of compounds, however, is that the mechanism of action of these agents are not as straightforward as was once previously assumed and the mechanisms of resistance that tumor cells employ to evade complete destruction are unlike any that have been described before. These discoveries in addition to utilization of modern molecular biology techniques have led to a series of hypotheses regarding which other types of molecules could be used in combination with BRAF-inhibitors in hopes of revolutionizing the potential of therapeutics in melanoma.
- Contents
- 1. Melanoma: Historical Context -- 2. Melanoma Pathogenesis -- 3. Molecular Diagnostics and Tumor Mutational Analysis -- 4. Clinical Utility of BRAF-Targeted Therapy in Melanoma -- 5. The Ethics of Randomized Trials in Oncology -- 6. Parallel and Serial Blockade Strategies in BRAF-Mutant Melanoma -- 7. Targeting the Cell Cycle and p53 in Combination with BRAF-Directed Therapy -- 8. Combination BRAF-Directed Therapy and Immunotherapy -- 9. Moving Forward: Making BRAF-Targeted Therapy Better.
- Format
- e-Book
- Location
- Online
Breast Cancer Biology for the Radiation Oncologist
https://libcat.nshealth.ca/en/permalink/provcat39392
Jonathan Strauss, William Small, Gayle E. Woloschak, editors.
--Berlin, Heidelberg:
Springer
, c2015.
- Available Online
- View e-Book
- Location
- Online
Breast Cancer Biology for the Radiation Oncologist is the first textbook of its kind devoted to describing the biological complexities of breast cancer in a way that is relevant to the radiation oncologist. Radiation Oncology has long treated breast cancer as a single biological entity, with all treatment decisions being based on clinical and pathologic risk factors. We are now beginning to understand that biological subtypes of breast cancer may have different risks of recurrence as well as di…
- Available Online
- View e-Book
- Other Authors
- Strauss, Jonathan
- Small, William
- Woloschak, Gayle E
- Responsibility
- Jonathan Strauss, William Small, Gayle E. Woloschak, editors
- Place of Publication
- Berlin, Heidelberg
- Publisher
- Springer
- Date of Publication
- c2015
- Physical Description
- 1 online resource (vii, 90 p. : 15 illus., 5 illus. in color)
- Series
- Medical radiology. Radiation oncology
- Series Title
- Medical radiology (Series)
- ISBN
- 9783642312205
- 9783642312199 (print ed.)
- ISSN
- 0942-5373
- Subjects (MeSH)
- Breast neoplasms - genetics
- Breast Neoplasms - physiopathology
- Breast neoplasms - radiotherapy
- Abstract
- Breast Cancer Biology for the Radiation Oncologist is the first textbook of its kind devoted to describing the biological complexities of breast cancer in a way that is relevant to the radiation oncologist. Radiation Oncology has long treated breast cancer as a single biological entity, with all treatment decisions being based on clinical and pathologic risk factors. We are now beginning to understand that biological subtypes of breast cancer may have different risks of recurrence as well as different intrinsic sensitivity to radiotherapy. Multi-gene arrays that have for years been used to predict the risk of distant recurrence and the value of systemic chemotherapy may also have utility in predicting the risk of local recurrence. Additionally, the targeted agents used to treat breast cancer may interact with radiotherapy in ways that can be beneficial or undesirable. All of these emerging issues of central importance to radiation oncologists are extensively discussed in this book, and practical treatment recommendations based on available clinical evidence are presented whenever possible.
- Contents
- Biological subtypes of breast cancer -- Oncogene amplification and Herceptin -- Current clinical use of genetic profiling -- Biology of DCIS and progression to invasive disease -- Cancer Stem Cells and Radiotherapy -- Genetic basis of normal tissue radiosensitivity and late toxicity -- Genetic syndromes and radiotherapy in breast cancer -- Experimental therapies in breast cancer.
- Format
- e-Book
- Location
- Online
Cancer Genetics
https://libcat.nshealth.ca/en/permalink/provcat30219
edited by Boris Pasche.
--Boston, MA:
Springer Science+Business Media
, c2010.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Author
- Pasche, Boris
- Responsibility
- edited by Boris Pasche
- Place of Publication
- Boston, MA
- Publisher
- Springer Science+Business Media
- Date of Publication
- c2010
- Series Vol.
- 155
- Series Title
- Cancer treatment and research
- ISBN
- 9781441960337
- Subjects (MeSH)
- Neoplasms - genetics
- Format
- e-Book
- Location
- Online
Cancer genetics
https://libcat.nshealth.ca/en/permalink/provcat19466
- Available Online
- View e-Journal
- Publisher
- Elsevier
- Holdings
- Vol 204, 2011 -
- Publication Frequency
- Monthly
- ISSN
- 2210-7762
- Specialty
- Genetics, Medical
- Medical Oncology
- Format
- e-Journal
- Location
- Online
