topic:"Gynecology" found 3 records - Provincial Hospitals Library Catalogue

Most deaths from carcinomas are caused by the hematogenous dissemination of cancer cells to distant organs and the eventual development of metastases. When found in the bone marrow or peripheral blood of carcinoma patients, occult cancer cells are referred to as disseminated tumor cells (DTCs) or circulating tumor cells (CTCs). CTCs and DTCs are considered surrogates of minimal residual disease, i.e., the presence of malignant cells in distant organs that are undetectable by conventional imagin…

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Other Authors: Ignatiadis, Michail; Sotiriou, Christos; Pantel, Klaus

Responsibility: Michail Ignatiadis, Christos Sotiriou, Klaus Pantel, editors

Place of Publication: Berlin, Heidelberg

Publisher: Springer

Date of Publication: c2012

Physical Description: 1 online resource (xiv, 253 p. : 35 ill., 28 ill. in color)

Series Vol.: 195

Series Title: Recent results in cancer research

ISBN: 9783642281600

Subjects (MeSH): Breast Neoplasms - diagnosis; Neoplasm Metastasis; Neoplasm, Residual; Neoplastic Cells, Circulating

Subjects (LCSH): Oncology; Gynecology; Cancer - Surgery; Pathology

Abstract: Most deaths from carcinomas are caused by the hematogenous dissemination of cancer cells to distant organs and the eventual development of metastases. When found in the bone marrow or peripheral blood of carcinoma patients, occult cancer cells are referred to as disseminated tumor cells (DTCs) or circulating tumor cells (CTCs). CTCs and DTCs are considered surrogates of minimal residual disease, i.e., the presence of malignant cells in distant organs that are undetectable by conventional imaging and laboratory tests used for tumor staging after curative surgery of the primary tumor. In this book, leading investigators in the field provide up-to-date information on a series of important questions, including: How can the study of minimal residual disease and CTCs help us to better understand breast cancer metastasis? What technologies are available for the detection and characterization of CTCs and DTCs, and what are their relative merits? How are DTCs and CTCs relevant to clinical research and practice? What is the role of other blood-based biomarkers such as circulating endothelial cells and circulating nucleic acids? What are the challenges in drug and biomarker co-development and the use of CTCs for companion diagnostic development? This book will be of interest and assistance to all who are engaged in the modern management of breast cancer.

Contents: Part I. Introduction -- Part II. Minimal Residual Disease and Breast Cancer Metastasis -- Part III. Technologies for Circulating Tumor Cell and Disseminated Tumor Cell Detection and Characterization -- Part IV. Other Blood-Based Biomarkers -- Part V. Disseminated Tumor Cells and Circulating Tumor Cells in Breast Cancer Clinical Research and Practice -- Part VI. Drug and Circulating Tumor Cell Co-development -- References.