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Antimicrobial peptides and innate immunity

https://libcat.nshealth.ca/en/permalink/provcat32483
Pieter S. Hiemstra, Sebastian A. J. Zaat, editors. --Basel: Springer , c2013.
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Antimicrobial peptides have been the subject of intense research in the past decades, and are now considered as an essential part of the defense system in bacteria, plants, animals and humans. This book provides an update on these effector molecules of the innate immune system both for researchers who are already actively involved in the area, and for those with a general interest in the topic. The book starts with an overview of the evolution of cysteine-containing antimicrobial peptides (inc…
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Other Authors
Hiemstra, Pieter S
Zaat, Sebastian A. J
Responsibility
Pieter S. Hiemstra, Sebastian A. J. Zaat, editors
Place of Publication
Basel
Publisher
Springer
Date of Publication
c2013
Physical Description
1 online resource (xi, 384 p. : 38 ill., 23 ill. in color)
Series Title
Progress in inflammation research
ISBN
9783034805414
Subjects (MeSH)
Antimicrobial Cationic Peptides - immunology
Immunity, Innate - immunology
Subjects (LCSH)
Immunology
Microbiology
Infectious diseases
Biochemistry
Abstract
Antimicrobial peptides have been the subject of intense research in the past decades, and are now considered as an essential part of the defense system in bacteria, plants, animals and humans. This book provides an update on these effector molecules of the innate immune system both for researchers who are already actively involved in the area, and for those with a general interest in the topic. The book starts with an overview of the evolution of cysteine-containing antimicrobial peptides (including defensins), and the role of these peptides in host defense in plants and micro-organisms. The realization that antimicrobial peptides also display functions distinct from their direct antimicrobial action is the focus of the next chapters, and puts these peptides center stage in immunity and wound repair. Further chapters discuss the role of antimicrobial peptides in disease, by providing an overview of mechanisms in bacterial resistance to antimicrobial peptides and a discussion of their role in inflammatory bowel disease, cystic fibrosis lung disease and chronic obstructive pulmonary disease. Finally, the book shows how knowledge of the function of antimicrobial peptides and their regulation can be used to design new therapies for inflammatory and infectious disorders. This is a very important area of research because of the increase in resistance of micro-organisms to conventional antibiotics. Therefore the use of synthetic or recombinant peptides, or agents that stimulate the endogenous production of antimicrobial peptides, provides an attractive alternative for conventional antibiotics.
Contents
Evolution of Antimicrobial Peptides: a View From the Cystine Chapel -- Innate immunity in plants: the role of antimicrobial peptides -- Antimicrobial peptides produced by microorganisms -- LL-37: an immunomodulatory antimicrobial host defence peptide -- Wound Repair and Antimicrobial Peptides -- WAPing out pathogens and disease in the mucosa-roles for SLPI and trappin-2 -- Histatins: multifunctional salivary antimicrobial peptides -- Structure-function relationships of antimicrobial chemokines -- Mechanisms and Significance of Bacterial Resistance to Human Cationic Antimicrobial Peptides -- Antimicrobial peptides and inflammatory bowel disease -- Cystic Fibrosis and Defective Airway Innate Immunity -- Antimicrobial peptides in chronic obstructive pulmonary disease -- Host defense peptides: Immune modulation and antimicrobial activity in vivo -- Helping the host induction of antimicrobial peptides as a novel therapeutic strategy against infections.
Format
e-Book
Location
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Atlas of the Mammalian Ovary : Morphological Dynamics and Potential Role of Innate Immunity

https://libcat.nshealth.ca/en/permalink/provcat31189
Katharina Spanel-Borowski. --Berlin, Heidelberg: Springer , c2012.
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In the era of molecular biology, an atlas that allows a rapid understanding of the complexity of ovarian processes is urgently needed. In this book, the author draws upon her own research, conducted over the past three decades, to provide a unique compilation of high-quality illustrations that offer illuminating insights in a readily accessible form. The ovarian follicles, the corpus luteum, and the interstitial cortex are presented as precisely controlled homeostatic compartments. Physiologic …
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Author
Spanel-Borowski, Katharina
Responsibility
Katharina Spanel-Borowski
Place of Publication
Berlin, Heidelberg
Publisher
Springer
Date of Publication
c2012
Physical Description
1 online resource (xiv, 141 p. : 78 ill., 58 ill. in color)
ISBN
9783642305351
Subjects (MeSH)
Immunity, Innate
Ovary - anatomy & histology - Atlases
Ovary - immunology
Subjects (LCSH)
Anatomy
Immunology
Gynecology
Endocrinology 
Reproductive medicine
Abstract
In the era of molecular biology, an atlas that allows a rapid understanding of the complexity of ovarian processes is urgently needed. In this book, the author draws upon her own research, conducted over the past three decades, to provide a unique compilation of high-quality illustrations that offer illuminating insights in a readily accessible form. The ovarian follicles, the corpus luteum, and the interstitial cortex are presented as precisely controlled homeostatic compartments. Physiologic cell death forms and leukocyte subtypes are clearly depicted, and the various steps in the ovulatory process are demonstrated in detail. Further topics addressed include the microvascular bed, the plasticity of intraovarian nerves as part of the remodelling processes in the polycystic and the menopausal ovary, and the role of cytokeratin-positive cells (of steroidogenic or microvascular origin) as messengers of innate immunity. This atlas will be a fascinating and informative resource for both trainees and more experienced professionals.
Contents
Introduction -- Follicle stages and follicular atresia without and with irradiation -- Follicular atresia as proliferative and inflammatory event -- Cortex and cellular stromolysis -- The ovulatory period as acute inflammatory response to oxidative stress and follicle cell harvest -- Corpus luteum cycle with focus on capillary sprouting and regression, eosinophils and KIT-positive cells -- Intraovarian oocyte release (IOR) with severe tissue damage -- Vascular stromolysis and vascular luteolysis for bulk tissue removal -- Polycystic and postmenopausal ovaries and negligible mast cells -- Cytokeratin-positive cells as dendritic-like cells and potential albumin-coexpression in follicles and corpus luteum -- Aspects of immunological control, novel concepts, challenges and clinical perspectives.
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e-Book
Location
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Basic immunology : functions and disorders of the immune system

https://libcat.nshealth.ca/en/permalink/provcat32088
Abul K. Abbas, Andrew H. Lichtman and Shiv Pillai. (6th ed.) --Philadelphia, PA: Elsevier , c2020.
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Meticulously reviewed and updated for today’s medical students, Basic Immunology, 6th Edition, is a concise text expertly written by the same distinguished author team as the best-selling, comprehensive text, Cellular and Molecular Immunology. This focused, easy-to-understand volume uses full-color illustrations and clinical images, useful tables, and practical features such as Summary Point boxes, end-of-chapter review questions, glossary terms, and clinical cases-all designed to help student…
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Author
Abbas, Abul K
Other Authors
Lichtman, Andrew H
Pillai, Shiv
Responsibility
Abul K. Abbas, Andrew H. Lichtman and Shiv Pillai
Edition
6th ed.
Place of Publication
Philadelphia, PA
Publisher
Elsevier
Date of Publication
c2020
Physical Description
1 online resource, 336 p.
ISBN
9780323549431
Subjects (MeSH)
Hypersensitivity
Immune System - physiology
Immunity
Immunologic Deficiency Syndromes
Subjects (LCSH)
Immunology
Specialty
Allergy and Immunology
Abstract
Meticulously reviewed and updated for today’s medical students, Basic Immunology, 6th Edition, is a concise text expertly written by the same distinguished author team as the best-selling, comprehensive text, Cellular and Molecular Immunology. This focused, easy-to-understand volume uses full-color illustrations and clinical images, useful tables, and practical features such as Summary Point boxes, end-of-chapter review questions, glossary terms, and clinical cases-all designed to help students master this complex topic in the most efficient, effective manner possible.
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Basic immunology : functions and disorders of the immune system

https://libcat.nshealth.ca/en/permalink/provcat50410
Abbas, Abul. (5th ed.) --Philadelphia, PA: Elsevier , 2016.
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Online
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Author
Abbas, Abul
Edition
5th ed.
Place of Publication
Philadelphia, PA
Publisher
Elsevier
Date of Publication
2016
ISBN
9780323390828
Subjects (MeSH)
Hypersensitivity
Immune System - physiology
Immunity
Immunologic Deficiency Syndromes
Notes
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e-Book
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Basic immunology : functions and disorders of the immune system

https://libcat.nshealth.ca/en/permalink/provcat21512
Abbas, Abul K. (2nd ed.) --Philadelphia, PA: Saunders , 2004.
Call Number
QW 504 A122b 2004
Location
Halifax Infirmary
Call Number
QW 504 A122b 2004
Author
Abbas, Abul K
Other Authors
Lichtman, Andrew H
Edition
2nd ed.
Place of Publication
Philadelphia, PA
Publisher
Saunders
Date of Publication
2004
Physical Description
322 p.
ISBN
072160241X
Subjects (MeSH)
Immunity
Immune System
Immune System Diseases
Format
Book
Location
Halifax Infirmary
Loan Period
3 weeks
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Cancer Immunology : A Translational Medicine Context

https://libcat.nshealth.ca/en/permalink/provcat39420
Nima Rezaei, editor. --Berlin, Heidelberg: Springer , c2015.
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Cancer Immunology is intended as an up-to-date, clinically relevant review of cancer immunology and immunotherapy. The rapid flow of studies in the field of cancer immunology during the last decade has increased our understanding of the interactions between the immune system and cancerous cells. In particular, it is now well known that such interactions result in the induction of epigenetic changes in cancerous cells and the selection of less immunogenic clones as well as alterations in immune …
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Other Authors
Rezaei, Nima
Responsibility
Nima Rezaei, editor
Place of Publication
Berlin, Heidelberg
Publisher
Springer
Date of Publication
c2015
Physical Description
1 online resource (xlvii, 597 p. : 269 illus., 246 illus. in color)
ISBN
9783662440063
9783662440056 (print ed.)
Subjects (MeSH)
Adaptive Immunity
Immunity, Innate
Neoplasms - immunology
Abstract
Cancer Immunology is intended as an up-to-date, clinically relevant review of cancer immunology and immunotherapy. The rapid flow of studies in the field of cancer immunology during the last decade has increased our understanding of the interactions between the immune system and cancerous cells. In particular, it is now well known that such interactions result in the induction of epigenetic changes in cancerous cells and the selection of less immunogenic clones as well as alterations in immune responses. Understanding the cross-talk between nascent transformed cells and cells of the immune system has led to the development of combinatorial immunotherapeutic strategies to combat cancer. This volume is focused on interactions between cancerous cells and various components of the innate and adaptive immune system are fully described. Notably, the principal focus is very much on clinical aspects, the aim being to educate clinicians on the clinical implications of the most recent findings and novel developments in the field. This is to be hoped that this translational book will be comprehensible, cogent and of special value for researchers and clinicians who wish to extend their knowledge on cancer immunology.
Contents
Introduction on cancer immunology and immunotherapy -- Inflammatory and innate immune cells in cancer microenvironment and progression -- Role of innate immunity in cancers and antitumor response -- Role of B cells in anti tumor response -- The role of exhaustion in tumor-induced T cell dysfunction in patients with cancer -- Regulatory T cells and Th17 cells in the immunosuppressive tumor network -- Role of cytokines in tumor immunity and immune tolerance to cancers -- Role of chemokines and chemokine receptors in cancers -- The role of Fas and Fas-ligand in cancers -- MHC class I molecules and cancer progression: Lessons learned from preclinical tumor models -- Role of plasmacytoid dendritic cells in cancer -- Cancer immunoediting: immunosurveillance, immuneequilibrium, and immune escape -- Apoptosis, autophagy and necroptosis in Cancer -- Prognostic value of innate and adaptive immunity in cancers -- Epigenetics and Micro RNAs in cancers -- Immunogenetics of cancers -- Immunodeficiencies and cancers -- Immunosenescence and cancers -- Nutrition, immunity and cancers -- Allergies and cancers -- Cancer immunology of transmissible cancers -- Systems biology and systems immunology of cancer -- Principles of immunological diagnostic tests for cancers -- Flow cytometry in cancer immunotherapy: applications, analysis, quality control and future -- Immunohistochemistry of cancers -- Immunology and immunotherapy of graft versus host disease.
Format
e-Book
Location
Online
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Cancer Immunology : A Translational Medicine Context

https://libcat.nshealth.ca/en/permalink/provcat44907
Nima Rezaei, editor. (Second edition) --Cham: Springer , c2020.
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This book focusing on the immunopathology of cancers is published as part of the three-volume Springer series Cancer Immunology, which aims to provide an up-to-date, clinically relevant review of cancer immunology and immunotherapy. Readers will find detailed descriptions of the interactions between cancerous cells and various components of the innate and adaptive immune system. The principal focus, however, is very much on clinical aspects, the aim being to educate clinicians in the clinical i…
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Other Authors
Rezaei, Nima.
Responsibility
Nima Rezaei, editor
Edition
Second edition
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2020
Physical Description
1 online resource (xvi, 802 p.) : 150 illus., 143 illus. in color
ISBN
9783030308452
9783030308445 (Print ed.)
9783030308469 (Print ed.)
9783030308476 (Print ed.)
Subjects (MeSH)
Adaptive Immunity
Immunity, Innate
Neoplasms - immunology
Specialty
Allergy and Immunology
Medical Oncology
Abstract
This book focusing on the immunopathology of cancers is published as part of the three-volume Springer series Cancer Immunology, which aims to provide an up-to-date, clinically relevant review of cancer immunology and immunotherapy. Readers will find detailed descriptions of the interactions between cancerous cells and various components of the innate and adaptive immune system. The principal focus, however, is very much on clinical aspects, the aim being to educate clinicians in the clinical implications of the latest research and novel developments in the field. In the new edition of this very well received book, first published in 2015, the original chapters have been significantly updated and additional chapters included on, for example, current knowledge on the roles of T-helper cells and NK cells in tumor immunity, the part played by oncoviruses in the development of various cancers, and the applications of fluorescent in situ hybridization, bioluminescence, and cancer molecular and functional imaging. Cancer Immunology: A Translational Medicine Context will be of special value to clinical immunologists, hematologists, and oncologists.
Contents
1. Introduction on Cancer Immunology and Immunotherapy -- 2. Role of Innate Immunity in Cancers and Antitumor Response -- 3. Tumor-Associated Myeloid Cells in Cancer Progression -- 4. B-Cells in Cancer Immunology: For or Against Cancer Growth? -- 5. The Roles of CD4+ T-Cells in Tumor Immunity -- 6. Regulatory T-Cells and Th17 Cells in Tumor Microenvironment -- 7. T-Cell Metabolism and Its Dysfunction Induced by Cancer -- 8. The Role of Exhaustion in Tumor-Induced T-Cell Dysfunction in Cancer -- 9. The Role of NK Cells in Cancer - 10. Role of Plasmacytoid Dendritic Cells in Cancer -- 11. The CD95/CD95L Signaling Pathway: A Role in Carcinogenesis -- 12. MHC Class I Molecules and Cancer Progression: Lessons Learned from Preclinical Mouse Models -- 13. Role of Cytokines in Tumor Immunity and Immune Tolerance to Cancer -- 14. Role of Chemokines and Chemokine Receptors in Cancer -- 15. Role of the Inflammasome in Cancer -- 16. Cancer Immunoediting: Immunosurveillance, Immune Equilibrium, and Immune Escape -- 17. Apoptosis and Cancer -- 18. Endoplasmic Reticulum Stress and Autophagy in Cancer -- 19. Prognostic Value of Innate and Adaptive Immunity in Cancers -- 20. Immunogenetics of Cancer -- 21. Epigenetics and MicroRNAs in Cancer -- 22. The Role of DNA Methylation in Cancer -- 23. Immunosenescence, Oxidative Stress, and Cancers -- 24. Nutrition, Immunity, and Cancers -- 25. Inborn Errors of Immunity and Cancers -- 26. Allergies and Cancers -- 27. Envisioning the Application of Systems Biology in Cancer Immunology -- 28. Principles of Immunological Diagnostic Tests for Cancers -- 29. Immunohistochemistry of Cancers -- 30. Fluorescent In Situ Hybridization: Methods and Application in Cancer Diagnosis -- 31. Cancer Molecular and Functional Imaging -- 32. Cancer Imaging with Radiolabeled Monoclonal Antibodies -- 33. Flow Cytometry in Cancer Immunotherapy: Applications, Quality Assurance, and Future.
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e-Book
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Cellular and molecular immunology

https://libcat.nshealth.ca/en/permalink/provcat33146
editors Abul K. Abbas, Andrew H. Lichtman, Shiv Pillai ; illustrations by David L. Baker. (10th ed.) --Philadelphia, PA: Elsevier , c2022.
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Well-written, readable, and superbly illustrated, Cellular and Molecular Immunology, 10th Edition, continues the tradition of excellence established through multiple editions of this bestselling text. Offering an unparalleled introduction to this complex field, it retains a practical, clinical focus while updating and revising all content to ensure clarity and comprehension, bringing readers fully up to date with new and emerging information in this challenging area.
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Other Authors
Abbas, Abul K.
Lichtman, Andrew H.
Pillai, Shiv
Responsibility
editors Abul K. Abbas, Andrew H. Lichtman, Shiv Pillai ; illustrations by David L. Baker
Edition
10th ed.
Place of Publication
Philadelphia, PA
Publisher
Elsevier
Date of Publication
c2022
Physical Description
1 online resource, 600 p.
ISBN
9780323757485
Subjects (MeSH)
Immunity, Cellular
Antibody Formation - immunology
Antigens - immunology
Immune System Diseases - immunology
Lymphocytes - immunology
Subjects (LCSH)
Immunity, Cellular
Antibody Formation - immunology
Antigens - immunology
Immune System Diseases - immunology
Lymphocytes - immunology
Cellular immunity
Molecular immunology
Specialty
Allergy and Immunology
Cell Biology
Molecular Medicine
Abstract
Well-written, readable, and superbly illustrated, Cellular and Molecular Immunology, 10th Edition, continues the tradition of excellence established through multiple editions of this bestselling text. Offering an unparalleled introduction to this complex field, it retains a practical, clinical focus while updating and revising all content to ensure clarity and comprehension, bringing readers fully up to date with new and emerging information in this challenging area.
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Cellular and molecular immunology

https://libcat.nshealth.ca/en/permalink/provcat50476
Abbas, Abul K. (10th ed.) --Philadelphia, PA: Elsevier , 2022.
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Location
Online
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Author
Abbas, Abul K.
Other Authors
Lichtman, Andrew H.
Pillai, Shiv
Edition
10th ed.
Place of Publication
Philadelphia, PA
Publisher
Elsevier
Date of Publication
2022
ISBN
9780323757485
Subjects (MeSH)
Immunity, Cellular
Antibody Formation - immunology
Antigens - immunology
Immune System Diseases - immunology
Lymphocytes - immunology
Notes
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e-Book
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Cellular and molecular immunology

https://libcat.nshealth.ca/en/permalink/provcat21577
Abbas, Abul K. (5th ed.) --Philadelphia, PA: Saunders , 2003.
Call Number
QW 568 A122c 2003
Location
Dickson Building
Call Number
QW 568 A122c 2003
Author
Abbas, Abul K
Other Authors
Lichtman, Andrew H
Edition
5th ed.
Place of Publication
Philadelphia, PA
Publisher
Saunders
Date of Publication
2003
Physical Description
562 p.
ISBN
0721600085
Subjects (MeSH)
Immunity, Cellular
Antibody Formation - immunology
Antigens - immunology
Lymphocytes - immunology
Immune System Diseases - immunology
Format
Book
Location
Dickson Building
Loan Period
3 weeks
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Clinical immunology : principles and practice

https://libcat.nshealth.ca/en/permalink/provcat32094
[edited by] Robert R. Rich ... [et al.]. (5th ed.) --[London, UK]: Elsevier , c2019.
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Keep abreast of the latest advances in this complex field with the 5th Edition of Clinical Immunology: Principles and Practice. This substantially revised edition by Drs. Robert R. Rich, Thomas A. Fleisher, William T. Shearer, Harry W. Schroeder, Jr., Anthony J. Frew, and Cornelia M. Weyand, offers authoritative guidance from some of the most respected global leaders in immunology, helping you navigate today’s latest knowledge and evidence-based practices that result in improved patient care.
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Rich, Robert R
Fleisher, Thomas A
Responsibility
[edited by] Robert R. Rich ... [et al.]
Edition
5th ed.
Alternate Title
Immunology
Place of Publication
[London, UK]
Publisher
Elsevier
Date of Publication
c2019
Physical Description
1 online resource, 1392 p.
ISBN
9780702068966
Subjects (MeSH)
Immune System - physiology
Immune System Diseases - immunology
Immunity - physiology
Subjects (LCSH)
Immune System - physiology
Immune System Diseases - immunology
Immunity - physiology
Immunology
Specialty
Allergy and Immunology
Abstract
Keep abreast of the latest advances in this complex field with the 5th Edition of Clinical Immunology: Principles and Practice. This substantially revised edition by Drs. Robert R. Rich, Thomas A. Fleisher, William T. Shearer, Harry W. Schroeder, Jr., Anthony J. Frew, and Cornelia M. Weyand, offers authoritative guidance from some of the most respected global leaders in immunology, helping you navigate today’s latest knowledge and evidence-based practices that result in improved patient care.
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Clinical immunology : principles and practice

https://libcat.nshealth.ca/en/permalink/provcat50512
Rich, Robert. (5th ed.) --Philadelphia, PA: Elsevier , 2019.
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Online
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Author
Rich, Robert
Edition
5th ed.
Place of Publication
Philadelphia, PA
Publisher
Elsevier
Date of Publication
2019
ISBN
9780702068966
Subjects (MeSH)
Immune System - physiology
Immune System Diseases - immunology
Immunity - physiology
Notes
Access to this online resource is restricted to IWK Health Centre employees working from inside the hospital network.
Format
e-Book
Location
Online
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Color atlas of immunology

https://libcat.nshealth.ca/en/permalink/provcat26744
Gerd-Rüdiger Burmester, Antonio Pezzutto ; with contributions by Timo Ulrichs and Alexandra Aicher ; 131 color plates by Jürgen Wiwrth. --Stuttgart: Thieme , c2003.
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Location
Online
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Author
Burmester, Gerd-Rüdiger
Other Authors
Pezzutto, Antonio
Responsibility
Gerd-Rüdiger Burmester, Antonio Pezzutto ; with contributions by Timo Ulrichs and Alexandra Aicher ; 131 color plates by Jürgen Wiwrth
Alternate Title
Colour atlas of immunology
Immunology
Place of Publication
Stuttgart
Publisher
Thieme
Date of Publication
c2003
Physical Description
1 online resource (xiv, 322 p.)
ISBN
9780865779648
9781604061116 (eISBN)
Subjects (MeSH)
Immunity - atlases
Immune System - Atlases
Immune System Diseases - Atlases
Specialty
Allergy and Immunology
Format
e-Book
Location
Online
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Developments in T Cell Based Cancer Immunotherapies

https://libcat.nshealth.ca/en/permalink/provcat39372
Paolo A. Ascierto, David F. Stroncek, Ena Wang, editors. (1st ed.) --Cham: Springer International Publishing : Imprint: Humana Press , c2015.
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Location
Online
This volume illustrates the salient aspects of cancer biology relevant to the successful implementation of immunotherapy. Topics include enhancement of antigen-specific immune responses by anti-cancer vaccines, modulation of the function of T cells within the tumor microenvironment, and the effects of genetic, epigenetic, developmental, and environmental determinants on T cell function. Other topics covered include the ex vivo expansion of T or other immune cells and their genetic modification …
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Other Authors
Ascierto, Paolo A
Stroncek, David F
Wang, Ena
Responsibility
Paolo A. Ascierto, David F. Stroncek, Ena Wang, editors
Edition
1st ed.
Place of Publication
Cham
Publisher
Springer International Publishing : Imprint: Humana Press
Date of Publication
c2015
Physical Description
1 online resource (xv, 305 p. : 26 illus. in color)
Series Title
Cancer drug discovery and development
ISBN
9783319211671
9783319211664 (print ed.)
ISSN
2196-9906
Subjects (MeSH)
Immunity, Cellular - immunology
Immunotherapy - methods
Neoplasms - immunology
Neoplasms - therapy
T-Lymphocytes - immunology
Abstract
This volume illustrates the salient aspects of cancer biology relevant to the successful implementation of immunotherapy. Topics include enhancement of antigen-specific immune responses by anti-cancer vaccines, modulation of the function of T cells within the tumor microenvironment, and the effects of genetic, epigenetic, developmental, and environmental determinants on T cell function. Other topics covered include the ex vivo expansion of T or other immune cells and their genetic modification or reprogramming to increase their ability to survive and expand when adoptively transferred back to the patients. Specific attention is devoted to the genetic manipulation of T cells through the introduction of re-directed T cell receptors, chimeric antibody receptors, and other genetic manipulation aimed at improving their effectiveness as anti-cancer agents. Furthermore, the revolutionary role of checkpoint inhibitors and their potential in combination with other immunotherapeutic approaches or with standard chemo and radiation therapy are extensively discussed.
Contents
1. Insights on Peptide Vaccines in Cancer Immunotherapy -- 2. Strategies for Improving Vaccines to Elicit T Cells to Treat Cancer -- 3. T Cell Fate in the Tumor Microenvironment -- 4 Influence of Antigen Receptor Avidity, Affinity, and Specificity on Genetically Engineered T Cells -- 5. Toward the Identification of Genetic Determinants of Responsiveness to Cancer Immunotherapy -- 6. Production of Clinical T Cell Therapies -- 7. Clinical Success of Adoptive Cell Transfer Therapy Using Tumor Infiltrating Lymphocytes -- 8. Harnessing Stem Cell-Like Memory T Cells for Adoptive Cell Transfer Therapy of Cancer -- 9. T Cell Blockade Immunotherapy Against Cancer and Abscopal Effect in Combination Therapy -- 10. T Cell Modulation: Anti-PD-1 Antibodies for the Treatment of Cancer -- 11. Enhancing T Cell Performance Against Cancer in Combination Treatment Strategies -- 12. Chimeric Antigen Receptor (CAR) T Cells -- 13. Rapamycin-Resistant T Cells and Pentostatin- Based Immuno-Selective Conditioning for the Allogeneic T Cell Therapy of Cancer.
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e-Book
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Online
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Essential clinical immunology

https://libcat.nshealth.ca/en/permalink/provcat27724
edited by John B. Zabriskie. --Cambridge: Cambridge University Press , 2009.
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Online
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Author
Zabriskie, John B
Responsibility
edited by John B. Zabriskie
Place of Publication
Cambridge
Publisher
Cambridge University Press
Date of Publication
2009
Physical Description
1 online resource (362 p.)
Series Title
Cambridge medicine
ISBN
9780511575266 (ebook)
9780521516815 (hardback)
Subjects (MeSH)
Immunity
Immune System
Immune System Diseases
Contents
Basic components of the immune system / John B. Zabriskie -- Immunological techniques / John B. Zabriskie -- Immune regulation / Nina Bhardwaj, David O'Neill, and Thomas Waldmann -- Immunological aspects of infection / Kumar Visvanathan ... [et al.] -- Immunological aspects of immunodeficiency diseases / Dinakantha S. Kumararatne -- Autoimmunity / Haoyang Zhuang ... [et al.] -- Chronic lymphocytic leukemia / Nicholas Chiorazzi and Manlio Ferrarini -- Immunology of HIV infections / Anders G. Vahlne -- Immunological aspects of allergy and anaphylaxis / Paul M. Ehrlich and Jonathan D. Field -- Immunological aspects of skin diseases / James G. Krueger and Lisa Zaba -- Experimental approaches to the study of autoimmune rheumatic diseases / Dalit Ashany and Mary K. Crow -- Immunological aspects of cardiac disease / John B. Zabriskie ... [et al.] -- Immunological aspects of chest diseases : the case of tuberculosis / Ernesto Muñoz-Elías and Robert J. Wilkinson -- Immunological aspects of gastrointestinal and liver disease / Christine Moung and Lloyd Mayer -- Immunological aspects of endocrine disease / Jean-François Bach -- Immune-mediated neurological syndromes / Jacqueline Friedman -- Immunological aspects of renal disease / Gil Cu and John B. Zabriskie -- Immunological aspects of transplantation / Jeffrey M. Venstrom and James W. Young.
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e-Book
Location
Online
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Footmarks of Innate Immunity in the Ovary and Cytokeratin-Positive Cells as Potential Dendritic Cells

https://libcat.nshealth.ca/en/permalink/provcat30455
by Katharina Spanel-Borowski. --Berlin, Heidelberg: Springer-Verlag , c2011.
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Online
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Author
Spanel-Borowski, Katharina
Responsibility
by Katharina Spanel-Borowski
Place of Publication
Berlin, Heidelberg
Publisher
Springer-Verlag
Date of Publication
c2011
Series Vol.
209
Series Title
Advances in anatomy, embryology and cell biology
ISBN
9783642160776
Subjects (MeSH)
Immunity, Innate
Dendritic Cells - immunology
Keratins - immunology
Ovary - immunology
Subjects (LCSH)
Cytology
Immunology
Reproductive medicine
Format
e-Book
Location
Online
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From Basic to Clinical Immunology

https://libcat.nshealth.ca/en/permalink/provcat44239
Vladimir V. Klimov. --Cham: Springer , 2019.
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Location
Online
This book fills a gap at the interface of fundamental and clinical immunology, and allergy. For many years, experts in fundamental immunology and physicians involved in clinical immunology and allergy worked separately – but the fundamental immunologists did not have medical qualifications and the physicians were not involved in the field of fundamental research. Written by a teacher and an expert in both fields, this book combines current knowledge on basic immunology and immunopathology with …
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Author
Klimov, Vladimir V.
Responsibility
Vladimir V. Klimov
Place of Publication
Cham
Publisher
Springer
Date of Publication
2019
Physical Description
1 online resource (xix, 377 p.) : 115 illus., 108 illus. in color
ISBN
9783030033231
9783030033224 (Print ed.)
9783030033248 (Print ed.)
Subjects (MeSH)
Immune System Diseases
Immune System Phenomena
Immune System - physiology
Immunity
Specialty
Allergy and Immunology
Abstract
This book fills a gap at the interface of fundamental and clinical immunology, and allergy. For many years, experts in fundamental immunology and physicians involved in clinical immunology and allergy worked separately – but the fundamental immunologists did not have medical qualifications and the physicians were not involved in the field of fundamental research. Written by a teacher and an expert in both fields, this book combines current knowledge on basic immunology and immunopathology with clinical comments that complete the whole picture. Immunology is a complex science, which requires a simplified approach in order to be taught and understood effectively. This book is based on the authors’ long experience in teaching undergraduate, postgraduate students and interns both basic and clinical immunology. Reviewing a variety of important components related to the immune system, it is clearly and logically structured, and enriched by figures, tables and boxes with important immunology definitions. Each chapter has its own bibliography, and most units include links to electronic quizzes and audio files to accompany readers step by step. This easy-to-follow volume concludes with suggestions for future study. It is a valuable resource for undergraduate and postgraduate students, as well as medical practitioners.
Contents
1. Functional Organization of the Immune System -- 2. Skin and Mucosal Immune System -- 3. Innate Immunity -- 4. Adaptive Immune Responses -- 5. Immunological and Molecular Biological Methods -- 6. Immunopathology -- 7. Immunology of Infectious Processes -- 8. Vaccination -- 9. Immune Enhancement Therapy -- 10. Anti-Allergy Medications -- 11. Allergen-Specific Immunotherapy (ASIT) -- Supplementary Information.
Format
e-Book
Location
Online
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Humoral Primary Immunodeficiencies

https://libcat.nshealth.ca/en/permalink/provcat44219
Mario Milco D'Elios, Marta Rizzi, editors. --Cham: Springer , 2019.
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Location
Online
This book presents detailed state of the art knowledge on the humoral primary immunodeficiencies (PIDs), i.e., disorders arising from impaired antibody production due to defects intrinsic to B cells or defective interaction between B and T cells. There is extensive coverage of both basic science discoveries and the latest clinical advances in the field. The book is structured in accordance with the most recent classification of PIDs and also covers updates on the B cell immunological synapse. R…
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Other Authors
D'Elios, Mario Milco
Rizzi, Marta
Responsibility
Mario Milco D'Elios, Marta Rizzi, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
2019
Physical Description
1 online resource (x, 387 p.) : 34 illus. in color
Series
Rare Diseases of the Immune System
Series Title
Rare diseases of the immune system
ISBN
9783319917856
9783319917849 (Print ed.)
9783319917863 (Print ed.)
ISSN
2282-6505
Subjects (MeSH)
Immunity, Humoral - immunology
Immunologic Deficiency Syndromes - immunology
Immunologic Deficiency Syndromes - therapy
Specialty
Allergy and Immunology
Abstract
This book presents detailed state of the art knowledge on the humoral primary immunodeficiencies (PIDs), i.e., disorders arising from impaired antibody production due to defects intrinsic to B cells or defective interaction between B and T cells. There is extensive coverage of both basic science discoveries and the latest clinical advances in the field. The book is structured in accordance with the most recent classification of PIDs and also covers updates on the B cell immunological synapse. Readers will find comprehensive, in-depth descriptions of novel humoral PID genes and related clinical applications, mucosal B cells, and the various clinical phenotypes of humoral PIDs. Aspects such as differential diagnosis, clinical management in children and adults, and the role of vaccines are also addressed. The authors are all recognized experts from Europe, Australia, and the United States. Humoral Primary Immunodeficiencies will be of high value for immunologists, pediatricians, rheumatologists, oncologists, internists, and infectious disease specialists and will also be informative for MD and PhD students.
Contents
1. The B-Side of the Immune Response -- 2. Mucosal B Cells -- 3. CVID -- 4. Late-Onset Combined Immunodeficiencies (LOCID) -- 5. Genetics of CVID -- 6. ICOS Deficiency -- 7. CD19 Deficiency due to Genetic Defects in the CD19 and CD81 Genes -- 8. Genetic CD21 Deficiency -- 9. TACI Deficiency -- 10. LRBA Deficiency -- 11. BAFF Receptor Deficiency -- 12. TWEAK Deficiency -- 13. NFKB2 Defects -- 14. The WHIM Syndrome -- 15. Class-Switch Recombination Defects -- 16. Selective IgA Deficiency -- 17. IgG Subclass and Anti-polysaccharide Antibody Deficiency -- 18. Good’s Syndrome (GS): Thymoma with Immunodeficiency -- 19. Differential Diagnosis in Hypogammaglobulinemia -- 20. Management of Humoral Primary Immunodeficiencies in Pediatrics -- 21. Management of Humoral Primary Immunodeficiencies in Adults -- 22. Vaccines in Humoral Primary Immunodeficiencies -- 23. Malignancy in Predominantly Antibody Deficiencies (PAD) -- 24. Humoral Primary Immunodeficiency and Autoimmune and Inflammatory Manifestations -- 25. Chest Complications in Patients with Primary Antibody Deficiency Syndromes (PADS) -- 26. Gastrointestinal Complications in Primary Immunoglobulin Deficiencies.
Format
e-Book
Location
Online
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IL-17, IL-22 and their producing cells : role in inflammation and autoimmunity

https://libcat.nshealth.ca/en/permalink/provcat32482
Valérie Quesniaux, Bernhard Ryffel, Franco Padova, editors. (2nd ed.) --Basel: Springer , c2013.
Available Online
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Location
Online
The knowledge of Th17 cells and other cell populations which secrete IL-17A, and/or IL-22 has expanded tremendously since the publication of the first edition "Th17 Cells: Role in Inflammation and Autoimmune Disease" in 2008. The present volume has been completely revised with the addition of new chapters on the IL-17 receptor family and signaling, and an in-depth review of IL-22 and innate lymphoid cells. The differentiation of naive T cells into regulatory T cells and Th17 cells as well as th…
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Other Authors
Quesniaux, Valérie
Ryffel, Bernhard
Padova, Franco
Responsibility
Valérie Quesniaux, Bernhard Ryffel, Franco Padova, editors
Edition
2nd ed.
Place of Publication
Basel
Publisher
Springer
Date of Publication
c2013
Physical Description
1 online resource (ix, 354 p. : 25 ill., 14 ill. in color)
Series Title
Progress in inflammation research
ISBN
9783034805223
Subjects (MeSH)
Immunity, Cellular - physiology
Inflammation - physiopathology
Interleukin-17 - immunology
Interleukins - immunology
Subjects (LCSH)
Oncology
Immunology
Infectious diseases
Cell receptors
Cytokines
Cytology
Abstract
The knowledge of Th17 cells and other cell populations which secrete IL-17A, and/or IL-22 has expanded tremendously since the publication of the first edition "Th17 Cells: Role in Inflammation and Autoimmune Disease" in 2008. The present volume has been completely revised with the addition of new chapters on the IL-17 receptor family and signaling, and an in-depth review of IL-22 and innate lymphoid cells. The differentiation of naive T cells into regulatory T cells and Th17 cells as well as the plasticity of Th17 cells is discussed. The role of IL-22 in cutaneous inflammation including psoriasis has been reviewed. In addition, the volume contains critical updates on autoimmunity, organ transplantation, tumor immunology and genetic mouse models for mechanistic studies. Lastly, the latest clinical progress in neutralizing antibodies to IL-17A, IL-17RA not only confirms the therapeutic promise foreseen in 2008, but also improves our knowledge of the pathogenesis of autoimmune diseases. In summary, this is a timely update and important review of the clinical and experimental aspects of IL-17, IL-22 and their producing cells.
Contents
IL-17A family, receptors, proinflammatory effects and production -- IL-22 and IL-17 overview -- IL-17R family: Structure, signal transduction and function -- Contribution of IL-22 to Th17 responses: repairing and protecting peripheral tissues -- Central role of Th-17 cells in adaptive immune responses -- Regulatory T cells vs Th17: Differentiation of Th17 versus Treg are they mutually exclusiveáOther sources of IL-17: iNKT cells -- Retinoic acid in mucosal immune regulation -- Critical role of IL-17 in experimental arthritis -- Dual role IL-17A, F and IL-22 in allergic asthma -- Inflammasome - IL-1 - IL-17 response in lung inflammation -- The role of Il-17 in exp autoimmune mycocarditis -- Th17 cells in transplantation: actors or innocent bystanders -- Is IL-17 required to control of tuberculosisáIL-17 and mucosal host defense. Role of IL-17 and IL-17 family cytokines on tumor development -- IL-17 and TH17 cells in rheumatoid arthritis and other inflammatory conditions -- Targeting Th17 Cells for therapy of multiple sclerosis -- Involvement of interleukin-17 cytokines in human asthma -- IL-17 and/or IL-22 as potential target(s) for Crohn's disease -- Role of IL-23, IL-17 and IL-22 in psoriasis -- Contribution of IL-22 to experimental skin inflammation -- Genetic mouse models to investigate IL-17 responses -- IL-17A as a therapeutic target for autoimmune diseases -- Index.
Format
e-Book
Location
Online
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Immunobiology : the immune system in health and disease

https://libcat.nshealth.ca/en/permalink/provcat53629
Janeway, Charles A. (4th ed.) --New York, NY: Current Biology Publications , 1999.
Call Number
QW 940 I73 1999
Location
IWK Health Sciences Library
Call Number
QW 940 I73 1999
Author
Janeway, Charles A.
Other Authors
Travers, Paul
Walport, Mark
Capra, J. Donald
Edition
4th ed.
Place of Publication
New York, NY
Publisher
Current Biology Publications
Date of Publication
1999
Physical Description
635 p.
ISBN
815332173
Subjects (MeSH)
Immune System - physiology
Immune System - physiopathology
Immunity
Immunotherapy
Format
Book
Location
IWK Health Sciences Library
Copies
1
Loan Period
2 weeks
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33 records – page 1 of 2.