Advances in tumor immunology and immunotherapy
https://libcat.nshealth.ca/en/permalink/provcat33290
Joseph D. Rosenblatt, Eckhard R. Podack, Glen N. Barber, Augusto Ochoa, editors.
--New York:
Springer
, c2014.
- Available Online
- View e-Book
- Location
- Online
Recent advances in understanding of fundamental immunology have created new insights into the dynamic interactions between tumors and the immune system. This includes new understanding of T- and B-cell interaction, immune inhibitory mechanisms including the biology of T regulatory cells, myeloid suppressor cells, and dendritic cell subsets. Enhanced understanding of mechanisms underlying T-cell anergy such as arginine deprivation, immunosuppressive cytokines, defective innate and interferon res…
- Available Online
- View e-Book
- Other Authors
- Rosenblatt, Joseph D
- Responsibility
- Joseph D. Rosenblatt, Eckhard R. Podack, Glen N. Barber, Augusto Ochoa, editors
- Place of Publication
- New York
- Publisher
- Springer
- Date of Publication
- c2014
- Physical Description
- 1 online resource (ix, 371 pages)
- Series Title
- Current cancer research
- ISBN
- 9781461488095 (electronic bk.)
- 9781461488088
- Subjects (MeSH)
- Antigens, Neoplasm - immunology
- Neoplasms - immunology
- Neoplasms - therapy
- T-Lymphocytes, Cytotoxic - immunology
- Immunotherapy - methods
- Subjects (LCSH)
- Tumors - Immunological aspects
- Cancer - Immunological aspects
- Antigens, Neoplasm - immunology
- Neoplasms - therapy
- T-Lymphocytes, Cytotoxic - immunology
- Cancer - Immunotherapy
- Neoplasms - Immunology
- Abstract
- Recent advances in understanding of fundamental immunology have created new insights into the dynamic interactions between tumors and the immune system. This includes new understanding of T- and B-cell interaction, immune inhibitory mechanisms including the biology of T regulatory cells, myeloid suppressor cells, and dendritic cell subsets. Enhanced understanding of mechanisms underlying T-cell anergy such as arginine deprivation, immunosuppressive cytokines, defective innate and interferon response pathways, and NKG2D downregulation have all provided new insight into suppression of anti-tumors.
- Contents
- Part I. Immune Activation, Suppression and Manipulation of the Immune Antitumor Response -- Myeloid-Derived Suppressor Cells in Cancer -- The Role of B Cells in Shaping the Antitumor Immune Response -- Heat-Shock Protein-Based Cancer Immunotherapy -- Activation of NK Cell Responses and Immunotherapy of Cancer -- Induction of Tumor Immunity by Targeted Inhibition of Nonsense-Mediated mRNA Decay -- Employing T Cell Homeostasis as an Antitumor Strategy -- Adoptive Cell Therapy of Systemic Metastases Using erbB-2-Specific T Cells Redirected with a Chimeric Antibody-Based Receptor -- Part II. Evolving Clinical Immunotherapeutic Strategies -- Immunotherapy in Renal Cell Carcinoma -- Adoptive T-Cell Transfer as a Clinical Antitumor Strategy for Hematologic Malignancies -- Bifunctional Antibodies: Preclinical and Clinical Applications -- Clinical Development of Antibody-Fusion Proteins for Cancer Therapy -- Immunologic Outcomes of Allogeneic Stem Cell Transplantation: Graft-Versus-Host and Graft-Versus-Leukemia Responses and Implications for Future Therapy -- The Immune System in Head and Neck Squamous Cell Carcinoma: Interactions and Therapeutic Opportunities -- T Cell Co-regulatory Signals and Their Role in Cancer Therapy -- Assessment of Immune Response in Biotherapy Trials and Clinical Endpoints.
- Format
- e-Book
- Location
- Online
Atlas of Response to Immunotherapy
https://libcat.nshealth.ca/en/permalink/provcat45029
Egesta Lopci, Stefano Fanti, editors.
--Cham:
Springer
, c2020.
- Available Online
- View e-Book
- Location
- Online
This atlas is a concise but comprehensive guide to the diverse patterns of response to immunotherapy as observed on Positron Emission Tomography/Computed Tomography (PET/CT) and other conventional imaging modalities, including CT and Magnetic Resonance Imaging (MRI). The purpose for this publication is to fill the gap between the growing clinical relevance and utilization of immunotherapy in medical oncology, mainly based on checkpoint inhibitors, and the need for experienced imagers with relia…
- Available Online
- View e-Book
- Other Authors
- Lopci, Egesta
- Fanti, Stefano
- Responsibility
- Egesta Lopci, Stefano Fanti, editors
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2020
- Physical Description
- 1 online resource (viii, 127 p.) : 111 illus., 100 illus. in color
- ISBN
- 9783030311131
- 9783030311124 (Print ed.)
- 9783030311148 (Print ed.)
- 9783030311155 (Print ed.)
- Subjects (MeSH)
- Immunotherapy - methods
- Neoplasms - immunology
- Neoplasms - therapy
- Positron Emission Tomography Computed Tomography
- Treatment Outcome
- Specialty
- Biological Therapy
- Medical Oncology
- Abstract
- This atlas is a concise but comprehensive guide to the diverse patterns of response to immunotherapy as observed on Positron Emission Tomography/Computed Tomography (PET/CT) and other conventional imaging modalities, including CT and Magnetic Resonance Imaging (MRI). The purpose for this publication is to fill the gap between the growing clinical relevance and utilization of immunotherapy in medical oncology, mainly based on checkpoint inhibitors, and the need for experienced imagers with reliable tools assessing response to treatment. A series of disease-oriented chapters will present the imaging findings during immunotherapy in the major oncological settings, with helpful comparison of functional (PET/CT) and morphological (CT/MRI) patterns of response in individual cases. To complete the atlas, a dedicated chapter will focus on major pitfalls and immune-related adverse events (irAEs) affecting image interpretation during the course of immunotherapy. The concluding chapter will lastly examine the available data and potential developments of immuno-PET, which is considered as the novel frontier of research in this oncological scenario. The atlas will be of high value for radiologists and nuclear medicine specialists at all levels of experience.
- Contents
- Part I. Brief Introduction -- 1. Immunotherapy in Oncology -- 2. Evolution of Response Criteria in Immunotherapy -- Part II. Disease-Oriented Applications -- 3. CNS Tumors: PET/CT and MRI for Response Assessment of CNS Tumors Following Immunotherapy -- 4. Lung Cancer: 18F-FDG PET/CT for Response Assessment of Lung Following Immunotherapy -- 5. Malignant Pleural Mesothelioma: 18F-FDG PET/CT for Response Assessment of Malignant Pleural Mesothelioma Following Immunotherapy -- 6. Melanoma: 18F-FDG PET/CT for Response Assessment of Melanoma Following Immunotherapy -- 7. Genitourinary Tumors: PET/CT for Response Assessment of Genitourinary Tumors Following Immunotherapy -- 8. Hematologic Malignancies: PET/CT for Response Assessment of Hematologic Malignancies Following Immunotherapy -- 9. Other Tumor Types: 18F-FDG PET/CT for Response Assessment of Various Tumors Following Immunotherapy -- Part III. Potential Pitfalls to Response Assessment -- 10. Pitfalls and Immune-Related Adverse Events -- Part IV. New Radiopharmaceuticals -- 11. ImmunoPET: The Future of Response Evaluation for Cancer Immunotherapy.
- Format
- e-Book
- Publication Type
- Atlas
- Location
- Online
Cancer Immunology : Bench to Bedside Immunotherapy of Cancers
https://libcat.nshealth.ca/en/permalink/provcat39431
Nima Rezaei, editor.
--Berlin, Heidelberg:
Springer
, c2015.
- Available Online
- View e-Book
- Location
- Online
This translational book describes in detail the clinical application of novel approaches in cancer immunotherapy with the aim of educating clinicians in the implications of the most recent research and new developments in the field. The scope is broad, encompassing, for example, prognostic biomarkers for personalized cancer treatment, strategies for targeting tumor immunosuppression, gene therapy, virus-based vaccines, targeting of cancer stem cells, hematopoietic stem cell transplantation, the…
- Available Online
- View e-Book
- Other Authors
- Rezaei, Nima
- Responsibility
- Nima Rezaei, editor
- Place of Publication
- Berlin, Heidelberg
- Publisher
- Springer
- Date of Publication
- c2015
- Physical Description
- 1 online resource (l, 485 p. : 45 illus., 38 illus. in color)
- ISBN
- 9783662449462
- 9783662449455 (print ed.)
- Subjects (MeSH)
- Immunotherapy - methods
- Neoplasms - therapy
- Abstract
- This translational book describes in detail the clinical application of novel approaches in cancer immunotherapy with the aim of educating clinicians in the implications of the most recent research and new developments in the field. The scope is broad, encompassing, for example, prognostic biomarkers for personalized cancer treatment, strategies for targeting tumor immunosuppression, gene therapy, virus-based vaccines, targeting of cancer stem cells, hematopoietic stem cell transplantation, the role of T lymphocytes in cancer immunotherapy, use of monoclonal antibodies, and many more innovative approaches. Clinical immunologists, hematologists, and oncologists in particular will find the book to be of value in expanding their knowledge. The book is the second in a three-volume series, Cancer Immunology, which offers an up-to-date review of cancer immunology and immunotherapy. The remaining volumes focus on the immunopathology of cancers and cancer immunotherapy for organ-specific tumors. In total the series, designed for both clinicians and researchers, includes contributions from more than 250 scientists working at leading universities and institutes from across the world.
- Contents
- Frontiers in Cancer Immunotherapy -- Novel Strategy of Cancer Immunotherapy: Spiraling Up -- Novel Prognostic Biomarkers for Personalized Cancer Treatments -- Tumor Antigen and Epitope Identification for Pre-Clinical and Clinical Evaluation -- Strategies to Target Tumor Immunesuppression -- Immune Modulation of Drugs in Prevention and Treatment of Cancers -- Overcoming Immune Tolerance With Immune Checkpoint Blockade -- Gene therapy and Virus-Based Cancer Vaccines -- Cancer Stem Cells: Biology and Potential therapeutic Applications -- Hematopoietic Stem Cell Transplantation and Lymphodepletion in Treatment of Cancers -- Combination of Chemotherapy and Cytokine Therapy in Treatment of Cancers -- T Cell Immunotherapy: From Synthetic Biology to Clinical Practice -- Role of Gamma-Delta T Lymphocytes in Cancer Immunosurveillance and Immunotherapy -- Adoptive T Cell therapy: Optimizing Chemokine Receptor-Mediated Homing of T Cells in Cancer Immunotherapy -- Cellular therapy of Cancer With B Effector Cells -- Monoclonal Antibodies for Treatment of Cancers -- Pattern Recognition Receptors in Cancers and Immunotherapy by Triggering or Targeting of Toll Like Receptors Pathway -- Recent Advances in the Use of NK Cells Against Cancer -- Dendritic Cell Vaccines for Cancer Therapy: Fundamentals and Clinical Trials -- Tumor Associated Macrophages and iNOS in Cancer Immunotherapy -- Photodynamic therapy and Anti-Tumor Immune Response -- Polarization of Tumor Milieu: Therapeutic Implications -- Immunotherapies Targeting 5T4 Oncofoetal Glycoprotein -- Immune Monitoring During Clinical Development of Anti-CTLA-4 Antibody Therapy -- PD-1 Blockade in Cancer Therapy -- New Advances in Radioimmunotherapy for the Treatment of Cancers -- Psychoneuroendocrinoimmunotherapy of Cancers -- Ethical Considerations in Cancer Immunotherapy.
- Format
- e-Book
- Location
- Online
Cancer Immunology : Bench to Bedside Immunotherapy of Cancers
https://libcat.nshealth.ca/en/permalink/provcat46359
Nima Rezaei, editor.
(Second edition)
--Cham:
Springer
, c2021.
- Available Online
- View e-Book
- Access
- NEW Springer 2021
- Location
- Online
This translational, clinically oriented book describes in detail novel approaches to cancer immunotherapy, current strategies to target tumor immunosuppression, and prognostic biomarkers for personalized cancer treatments. Since the first, very successful edition of the book was published in 2015, the original chapters have been significantly updated and entirely new chapters are included on, for example, cancer immunoprevention, aptamer-mediated cancer gene therapy, haploidentical bone marrow …
- Available Online
- View e-Book
- Other Authors
- Rezaei, Nima
- Responsibility
- Nima Rezaei, editor
- Edition
- Second edition
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2021
- Physical Description
- 1 online resource (xl, 658 p.) : 53 illus., 46 illus. in color
- ISBN
- 9783030502874
- 9783030502867 (Print ed.)
- 9783030502881 (Print ed.)
- 9783030502898 (Print ed.)
- Subjects (MeSH)
- Immunotherapy - methods
- Neoplasms - immunology
- Neoplasms - therapy
- Abstract
- This translational, clinically oriented book describes in detail novel approaches to cancer immunotherapy, current strategies to target tumor immunosuppression, and prognostic biomarkers for personalized cancer treatments. Since the first, very successful edition of the book was published in 2015, the original chapters have been significantly updated and entirely new chapters are included on, for example, cancer immunoprevention, aptamer-mediated cancer gene therapy, haploidentical bone marrow transplantation for pediatric malignancies, and nanoimmunotherapy. The book is published as part of the three-volume Springer series Cancer Immunology, which aims to provide an up-to-date, clinically relevant review of cancer immunology and immunotherapy. Other volumes in the series address the translational medicine context and cancer immunotherapy for organ-specific tumors. Cancer Immunology: Bench to Bedside Immunotherapy of Cancers will be of special value to clinical immunologists, hematologists, and oncologists.
- Contents
- Frontiers in Cancer Immunotherapy -- Novel Strategy of Cancer Immunotherapy: Spiraling Up -- Novel Prognostic Biomarkers for Personalized Cancer Treatments -- Tumor Antigen and Epitope Identification for Pre-Clinical and Clinical Evaluation -- Strategies to Target Tumor Immunesuppression -- Immune Modulation of Drugs in Prevention and Treatment of Cancers -- Overcoming Immune Tolerance With Immune Checkpoint Blockade -- Gene therapy and Virus-Based Cancer Vaccines -- Cancer Stem Cells: Biology and Potential therapeutic Applications -- Hematopoietic Stem Cell Transplantation and Lymphodepletion in Treatment of Cancers -- Combination of Chemotherapy and Cytokine Therapy in Treatment of Cancers -- T Cell Immunotherapy: From Synthetic Biology to Clinical Practice -- Role of Gamma-Delta T Lymphocytes in Cancer Immunosurveillance and Immunotherapy -- Adoptive T Cell therapy: Optimizing Chemokine Receptor-Mediated Homing of T Cells in Cancer Immunotherapy -- Cellular therapy of Cancer With B Effector Cells -- Monoclonal Antibodies for Treatment of Cancers -- Pattern Recognition Receptors in Cancers and Immunotherapy by Triggering or Targeting of Toll Like Receptors Pathway -- Recent Advances in the Use of NK Cells Against Cancer -- Dendritic Cell Vaccines for Cancer Therapy: Fundamentals and Clinical Trials -- Tumor Associated Macrophages and iNOS in Cancer Immunotherapy -- Photodynamic therapy and Anti-Tumor Immune Response -- Polarization of Tumor Milieu: Therapeutic Implications -- Immunotherapies Targeting 5T4 Oncofoetal Glycoprotein -- Immune Monitoring During Clinical Development of Anti-CTLA-4 Antibody Therapy -- PD-1 Blockade in Cancer Therapy -- New Advances in Radioimmunotherapy for the Treatment of Cancers -- Psychoneuroendocrinoimmunotherapy of Cancers -- Ethical Considerations in Cancer Immunotherapy.
- Access
- NEW Springer 2021
- Format
- e-Book
- Location
- Online
Cancer Immunology : Cancer Immunotherapy for Organ-Specific Tumors
https://libcat.nshealth.ca/en/permalink/provcat39456
Nima Rezaei, editor.
--Berlin, Heidelberg:
Springer
, c2015.
- Available Online
- View e-Book
- Location
- Online
Cancer Immunology is intended as an up-to-date, clinically relevant review of cancer immunology and immunotherapy. This volume focuses on the immunopathology and immunotherapy of organ cancers in detail. It clearly explains their immunology and describes novel immunotherapy for specific cancers, including pediatric solid tumors, hematologic malignancies, gastrointestinal tumors, skin cancers, bone and connective tissue tumors, central nervous system tumors, lung cancers, genitourinary tract tum…
- Available Online
- View e-Book
- Other Authors
- Rezaei, Nima
- Responsibility
- Nima Rezaei, editor
- Place of Publication
- Berlin, Heidelberg
- Publisher
- Springer
- Date of Publication
- c2015
- Physical Description
- 1 online resource (xliii, 488 p. : 48 illus., 44 illus. in color)
- ISBN
- 9783662464106
- 9783662464090 (print ed.)
- Subjects (MeSH)
- Immunomodulation
- Immunotherapy - methods
- Neoplasms - therapy
- Organ Specificity
- Abstract
- Cancer Immunology is intended as an up-to-date, clinically relevant review of cancer immunology and immunotherapy. This volume focuses on the immunopathology and immunotherapy of organ cancers in detail. It clearly explains their immunology and describes novel immunotherapy for specific cancers, including pediatric solid tumors, hematologic malignancies, gastrointestinal tumors, skin cancers, bone and connective tissue tumors, central nervous system tumors, lung cancers, genitourinary tract tumors, and breast cancers. In so doing, it builds on the previous two volumes in Cancer Immunology, placing basic knowledge on tumor immunology and immunotherapy into a clinical perspective with the aim of educating clinicians on advances in cancer immunology and the most recent approaches in the immunotherapy of various tumors. This translational, clinically oriented book will be of special value to clinical immunologists, hematologists, and oncologists.
- Contents
- Specific Organ Tumors: General Considerations On Immunotherapy -- Vaccination Of Human Solid Tumors: Recent Progress In The Clinical Setting -- Immunotherapy For Pediatric Solid Tumors -- Immunopathology Of Hematological Cancers And Immunotherapy Of Leukemia And Multiple Myeloma -- Immunopathology Of Lymphoma And Immunotherapy Of Hodgkin's Disease And Non-Hodgkin's Lymphoma -- Cancer-Testis Antigens As Targets For The Immunotherapy Of Hematological Malignancies -- Tumor Immunology And Immunotherapy Of Gastrointestinal Tract Cancers -- Immunology And Immunotherapy Of Colorectal Cancer -- Immunopathology Of Hepatobiliary Tumors And Immunotherapy Of Liver Cancers -- Immunology And Immunotherapy Of Pancreatic Tumors -- Immunology Of Cutaneous Tumors And Immunotherapy For Melanoma -- Immunopathology Of Head And Neck Tumors And Immunotherapy Of Squamous Cell Carcinoma -- Immunopathology And Immunotherapy Of Oral Cancers -- Immunopathology Of Bone And Connective Tissue Cancers And Immunotherapy Of Sarcomas -- Immunopathology Of Central Nervous System Cancers And Immunotherapy Of Brain Tumors -- Immunology And Immunotherapy Of Pulmonary Tumors -- Immunopathology Of Urinary System Cancers And Immunotherapy Of Renal And Bladder Cancers -- Immunopathology Of Cancers Of Male And Female Genitalia Organs And Immunotherapy Of Cervical And Prostate Cancer -- Immunology And Immunotherapy Of Ovarian Cancer -- Revisiting Immunology For Breast Cancer -- Immunology And Immunotherapy Of Graft Versus Host Disease.
- Format
- e-Book
- Location
- Online
Cancer Immunology : Cancer Immunotherapy for Organ-Specific Tumors
https://libcat.nshealth.ca/en/permalink/provcat46145
Nima Rezaei, editor.
(Second edition)
--Cham:
Springer
, c2020.
- Available Online
- View e-Book
- Location
- Online
This book explains the immunology of organ-specific malignancies and discusses novel immunotherapy strategies for their treatment. Since the first, very successful edition of the book was published in 2015, a number of entirely new chapters have been included. The range of cancers considered has accordingly been extended, with coverage of the latest immunotherapy approaches for skin cancers, ocular malignancies, endocrine malignancies, cardiac cancers, vascular cancers, and HPV-associated cance…
- Available Online
- View e-Book
- Other Authors
- Rezaei, Nima
- Responsibility
- Nima Rezaei, editor
- Edition
- Second edition
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2020
- Physical Description
- 1 online resource (xxx, 581 p.) : 34 illus., 30 illus. in color
- ISBN
- 9783030579494
- 9783030579487 (Print ed.)
- 9783030579500 (Print ed.)
- 9783030579517 (Print ed.)
- Subjects (MeSH)
- Immunotherapy - methods
- Neoplasms - immunology
- Neoplasms - therapy
- Specialty
- Allergy and Immunology
- Medical Oncology
- Abstract
- This book explains the immunology of organ-specific malignancies and discusses novel immunotherapy strategies for their treatment. Since the first, very successful edition of the book was published in 2015, a number of entirely new chapters have been included. The range of cancers considered has accordingly been extended, with coverage of the latest immunotherapy approaches for skin cancers, ocular malignancies, endocrine malignancies, cardiac cancers, vascular cancers, and HPV-associated cancers. In addition, the original chapters have been updated to document the latest advances in immunotherapy for pediatric solid tumors, hematologic malignancies, gastrointestinal tumors, bone tumors, CNS tumors, lung cancer, genitourinary tract tumors, and breast cancer, among others. The book is published as part of the three-volume Springer series Cancer Immunology, which aims to provide an up-to-date, clinically relevant review of cancer immunology and immunotherapy. Other volumes in the series address the translational medicine context and bench to bedside immunotherapy. Cancer Immunology: Cancer Immunotherapy for Organ-Specific Tumors will be of special value to clinical immunologists, hematologists, and oncologists.
- Contents
- 1. Cancer Immunotherapy Confers a Global Benefit -- 2. Immunotherapy for Pediatric Solid Tumors -- 3. Immunotherapeutic Strategies for Multiple Myeloma -- 4. Immunopathology and Immunotherapy of Myeloid Leukemia -- 5. Immunopathology and Immunotherapy of Acute Lymphoblastic Leukemia -- 6. Immunopathology and Immunotherapy of Hodgkin Lymphoma -- 7. Immunopathology and Immunotherapy of Non-Hodgkin Lymphoma -- 8. Immunotherapy of Gastric and Esophageal Cancers -- 9. Hepatobiliary Tumors: Immunopathology and Immunotherapy -- 10. Immunology and Immunotherapy of Colorectal Cancer -- 11. Immunotherapy in Nonmelanoma Skin Cancers -- 12. Immunopathology and Immunotherapy of Melanoma -- 13. Immunopathology as a Basis for Immunotherapy of Head and Neck Squamous Cell Carcinoma -- 14. Immunotherapy and Immunosurveillance of Oral Cancers: Perspectives of Plasma Medicine and Mistletoe -- 15. Immunopathology of Bone and Connective Tissue Cancers and Immunotherapy of Sarcomas -- 16. Immunopathology and Immunotherapy of Central Nervous System Cancer -- 17. Immunotherapy of Lung Tumors -- 18. Immunotherapy in Bladder and Renal Cancers -- 19. Immunopathology of Specific Cancers in Males and Females and Immunotherapy of Prostate and Cervical Cancer -- 20. Immunology and Immunotherapy of Ovarian Cancer -- 21. Immunopathology and Immunotherapy for Breast Cancer -- 22. Immunology and Immunotherapy of Graft-Versus-Host Disease.
- Format
- e-Book
- Location
- Online
Chemotherapy and Immunotherapy in Urologic Oncology : A Guide for the Advanced Practice Provider
https://libcat.nshealth.ca/en/permalink/provcat46364
Edouard J. Trabulsi, Costas D. Lallas, Anne E. Lizardi-Calvaresi, editors.
--Cham:
Springer
, c2021.
- Available Online
- View e-Book
- Access
- NEW Springer 2021
- Location
- Online
This book is designed to familiarize clinical practitioners in systemic therapy options and medical management of urologic malignancies including prostate cancer, bladder and upper tract urothelial carcinoma, and renal cell carcinoma. Organized by organ system, the text highlights new therapies such as novel forms of androgen deprivation, cytotoxic chemotherapy, immune check point and immunomodulatory agents, and targeted therapies. Written by experts in the field, the book also reviews current…
- Available Online
- View e-Book
- Other Authors
- Trabulsi, Edouard J.
- Lallas, Costas D.
- Lizardi-Calvaresi, Anne E.
- Responsibility
- Edouard J. Trabulsi, Costas D. Lallas, Anne E. Lizardi-Calvaresi, editors
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2021
- Physical Description
- 1 online resource (xiv, 307 p.) : 22 illus., 19 illus. in color
- ISBN
- 9783030520212
- 9783030520205 (Print ed.)
- 9783030520229 (Print ed.)
- Subjects (MeSH)
- Antineoplastic Agents - therapeutic use
- Urologic Neoplasms - drug therapy
- Immunotherapy - methods
- Abstract
- This book is designed to familiarize clinical practitioners in systemic therapy options and medical management of urologic malignancies including prostate cancer, bladder and upper tract urothelial carcinoma, and renal cell carcinoma. Organized by organ system, the text highlights new therapies such as novel forms of androgen deprivation, cytotoxic chemotherapy, immune check point and immunomodulatory agents, and targeted therapies. Written by experts in the field, the book also reviews current chemotherapy and immunotherapy regimens for genitourinary malignancies and discusses indications, outcomes, and toxicities, as well as clinical trial concepts. Each of the book’s chapters offers a bulleted box of clinical pearls on the particular role of the APP. Chemotherapy and Immunotherapy in Urologic Oncology: A Guide for the Advanced Practice Provider is a resource for urologists, uro-radiologists, medical clinicians and family practitioners alike, familiarizing its audiences with systemic therapy regimens for urologic malignancies, as well as their expected outcomes and side effects. .
- Contents
- Introduction: Integration of APP into Urologic Oncology Practice -- Part I. Prostate Cancer -- Overview and Active Surveillance of Prostate Cancer -- Monitoring and Managing Men Following Initial Treatment of Prostate Cancer -- Radical Prostatectomy and Survivorship after Radical Prostatectomy -- Multimodal Treatment Plans in Prostate Cancer -- Radiotherapy for Prostate Cancer -- Androgen Deprivation Treatment -- Second Generation Androgen Targeted Agents -- Chemotherapy and prostate cancer -- Radiopharmaceuticals for Prostate Cancer -- Immunotherapy and Novel Agents on the Horizon for the Treatment of Prostate Cancer -- Part II. Bladder Cancer -- Bladder Cancer: Overview, Epidemiology, Initial Presentation and Diagnosis -- Intravesical Therapy for Non Muscle Invasive Urothelial Carcinoma -- Bladder Cancer: Muscle Invasive Disease, Neoadjuvant Chemotherapy, and Radical Cystectomy -- Chemoradiation Bladder Preservation -- Metastatic Bladder Cancer and the Use of Cisplatin Chemotherapy -- Immunotherapy for Metastatic Urothelial Cancer -- Novel and experimental Strategies in the Treatment of Metastatic Urothelial Carcinoma -- Upper Tract Urothelial Carcinoma -- Part III. Kidney Cancer -- Kidney Cancer and Its Treatment -- Targeted Therapies for Treatment of Metastatic Renal Cell Carcinoma -- Immune Therapies for Metastatic Kidney Cancer -- Novel Therapies for Renal Cell Carcinoma -- Part IV. Other Malignancies -- Testicular Cancer -- Penile Cancer.
- Access
- NEW Springer 2021
- Format
- e-Book
- Location
- Online
Developments in T Cell Based Cancer Immunotherapies
https://libcat.nshealth.ca/en/permalink/provcat39372
Paolo A. Ascierto, David F. Stroncek, Ena Wang, editors.
(1st ed.)
--Cham:
Springer International Publishing : Imprint: Humana Press
, c2015.
- Available Online
- View e-Book
- Location
- Online
This volume illustrates the salient aspects of cancer biology relevant to the successful implementation of immunotherapy. Topics include enhancement of antigen-specific immune responses by anti-cancer vaccines, modulation of the function of T cells within the tumor microenvironment, and the effects of genetic, epigenetic, developmental, and environmental determinants on T cell function. Other topics covered include the ex vivo expansion of T or other immune cells and their genetic modification …
- Available Online
- View e-Book
- Other Authors
- Ascierto, Paolo A
- Stroncek, David F
- Wang, Ena
- Responsibility
- Paolo A. Ascierto, David F. Stroncek, Ena Wang, editors
- Edition
- 1st ed.
- Place of Publication
- Cham
- Publisher
- Springer International Publishing : Imprint: Humana Press
- Date of Publication
- c2015
- Physical Description
- 1 online resource (xv, 305 p. : 26 illus. in color)
- Series Title
- Cancer drug discovery and development
- ISBN
- 9783319211671
- 9783319211664 (print ed.)
- ISSN
- 2196-9906
- Subjects (MeSH)
- Immunity, Cellular - immunology
- Immunotherapy - methods
- Neoplasms - immunology
- Neoplasms - therapy
- T-Lymphocytes - immunology
- Abstract
- This volume illustrates the salient aspects of cancer biology relevant to the successful implementation of immunotherapy. Topics include enhancement of antigen-specific immune responses by anti-cancer vaccines, modulation of the function of T cells within the tumor microenvironment, and the effects of genetic, epigenetic, developmental, and environmental determinants on T cell function. Other topics covered include the ex vivo expansion of T or other immune cells and their genetic modification or reprogramming to increase their ability to survive and expand when adoptively transferred back to the patients. Specific attention is devoted to the genetic manipulation of T cells through the introduction of re-directed T cell receptors, chimeric antibody receptors, and other genetic manipulation aimed at improving their effectiveness as anti-cancer agents. Furthermore, the revolutionary role of checkpoint inhibitors and their potential in combination with other immunotherapeutic approaches or with standard chemo and radiation therapy are extensively discussed.
- Contents
- 1. Insights on Peptide Vaccines in Cancer Immunotherapy -- 2. Strategies for Improving Vaccines to Elicit T Cells to Treat Cancer -- 3. T Cell Fate in the Tumor Microenvironment -- 4 Influence of Antigen Receptor Avidity, Affinity, and Specificity on Genetically Engineered T Cells -- 5. Toward the Identification of Genetic Determinants of Responsiveness to Cancer Immunotherapy -- 6. Production of Clinical T Cell Therapies -- 7. Clinical Success of Adoptive Cell Transfer Therapy Using Tumor Infiltrating Lymphocytes -- 8. Harnessing Stem Cell-Like Memory T Cells for Adoptive Cell Transfer Therapy of Cancer -- 9. T Cell Blockade Immunotherapy Against Cancer and Abscopal Effect in Combination Therapy -- 10. T Cell Modulation: Anti-PD-1 Antibodies for the Treatment of Cancer -- 11. Enhancing T Cell Performance Against Cancer in Combination Treatment Strategies -- 12. Chimeric Antigen Receptor (CAR) T Cells -- 13. Rapamycin-Resistant T Cells and Pentostatin- Based Immuno-Selective Conditioning for the Allogeneic T Cell Therapy of Cancer.
- Format
- e-Book
- Location
- Online
Early Phase Cancer Immunotherapy
https://libcat.nshealth.ca/en/permalink/provcat42936
Sandip Pravin Patel, Razelle Kurzrock, editors.
--Cham:
Springer
, c2018.
- Available Online
- View e-Book
- Location
- Online
This volume, a state-of-the-art review of early phase clinical trials for cancer immunotherapy, discusses biomarker selection, combinatorial strategies and their safety or toxicity, determination of Phase 2 dosing, endpoints in the setting of radiographic pseudoprogression, histology selection, and novel immunotherapeutics as they relate to early phase cancer immunotherapy.
- Available Online
- View e-Book
- Other Authors
- Patel, Sandip Pravin
- Kurzrock, Razelle
- Responsibility
- Sandip Pravin Patel, Razelle Kurzrock, editors
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2018
- Physical Description
- 1 online resource (xi, 331 p.) : 24 illus., 15 illus. in color
- Series Title
- Current cancer research
- ISBN
- 9783319637570
- 9783319637563 (print ed.)
- 9783319637587 (print ed.)
- 9783319876283 (print ed.)
- ISSN
- 2199-2584
- Subjects (MeSH)
- Clinical Trials, Phase I as Topic
- Clinical Trials, Phase II as Topic
- Immunotherapy - methods
- Neoplasms - therapy
- Specialty
- Medical Oncology
- Regenerative Medicine
- Abstract
- This volume, a state-of-the-art review of early phase clinical trials for cancer immunotherapy, discusses biomarker selection, combinatorial strategies and their safety or toxicity, determination of Phase 2 dosing, endpoints in the setting of radiographic pseudoprogression, histology selection, and novel immunotherapeutics as they relate to early phase cancer immunotherapy.
- Contents
- 1. Primer on Cancer Immunotherapy and the Targeting of Native Proteins -- 2. Pharmacokinetics and Pharmacodynamics of Immunotherapy -- 3. Immunotherapeutic Biomarkers and Selection Strategies -- 4. Radiographic Evaluation of Immunotherapy -- 5. Cellular Therapy -- 6. Combinatorial Checkpoint Blockade Immunotherapy and Radiation -- 7. Early Phase Cancer Immunotherapy -- 8. Immune Checkpoint Combinations with Inflammatory Pathway Modulators -- 9. Combinations of Genomically and Immune-Targeted Therapies in Early-Phase Clinical Trials -- 10. Thoracic Immunotherapy.
- Format
- e-Book
- Location
- Online
Gene therapy of cancer
https://libcat.nshealth.ca/en/permalink/provcat50735
Lattime, Edmund.
(3rd ed.)
--Philadelphia, PA:
Elsevier
, 2014.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Author
- Lattime, Edmund
- Edition
- 3rd ed.
- Place of Publication
- Philadelphia, PA
- Publisher
- Elsevier
- Date of Publication
- 2014
- ISBN
- 9780123942951
- Subjects (MeSH)
- Neoplasms - genetics
- Neoplasms - therapy
- Genetic Therapy - methods
- Immunotherapy - methods
- Protein Biosynthesis - genetics
- Notes
- Access to this online resource is restricted to IWK Health Centre employees working from inside the hospital network.
- Format
- e-Book
- Location
- Online
Immunotherapy for Gastrointestinal Cancer
https://libcat.nshealth.ca/en/permalink/provcat41450
David Kerr, Rebecca Johnson, editors.
--Cham:
Springer
, 2017.
- Available Online
- View e-Book
- Location
- Online
This book is about the manipulation of the immune system as a therapeutic approach to gastrointestinal cancer and its clinical applications, exploring therapeutic approaches which might be taken under the broad banner of immunotherapy. Starting by introducing concepts of modern immunology, the clinical applications of immunotherapy are then discussed. The reader will learn about the three broad classes of immune therapeutic agents: cell-based treatment; antibody therapy; cytokine application an…
- Available Online
- View e-Book
- Other Authors
- Kerr, David
- Johnson, Rebecca
- Responsibility
- David Kerr, Rebecca Johnson, editors
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- 2017
- Physical Description
- 1 online resource (viii, 252 pages) : 23 illus. in color
- ISBN
- 9783319430638
- 9783319430614 (print ed.)
- Subjects (MeSH)
- Gastrointestinal Neoplasms - therapy
- Immunotherapy - methods
- Abstract
- This book is about the manipulation of the immune system as a therapeutic approach to gastrointestinal cancer and its clinical applications, exploring therapeutic approaches which might be taken under the broad banner of immunotherapy. Starting by introducing concepts of modern immunology, the clinical applications of immunotherapy are then discussed. The reader will learn about the three broad classes of immune therapeutic agents: cell-based treatment; antibody therapy; cytokine application and the key effector cells and mechanisms which might cause tumour rejection. The reverse side of this equation, the genetic and molecular mechanisms which the tumour can use to escape immune control and regulation, is also discussed. Through reviewing the most up-to-date evidence, this volume provides an overview of the important scientific lessons learned from past failure of immunotherapeutics in the clinic and highlights more positive recent data, coupled to practical guidelines for clinical usage. Written by a team of worldwide experts, this is an indispensable guide for medical oncologists, surgical oncologists, radiation therapists, pharmacists, oncology nurse specialists.
- Contents
- 1. Introduction to Modern Immunology -- 2. Cell Based Therapy: Modified Cancer Cells -- 3. Therapeutic Cancer Vaccines -- 4. Antibody Drug and Radionuclide Conjugates for GI Cancers -- 5. Antibodies that Inhibit Specific Cellular Pathways in Gastric Cancer -- 6. PD1 and PD-L1 Immune Checkpoint Inhibitors in Gastrointestinal Cancer -- 7. The Role of the JAK/STAT Signalling Pathway in Immunoregulation of Gastrointestinal Cancers -- 8. Hypermutated Colorectal Cancer and Neoantigen Load -- 9. Antibodies for Treatment of Metastatic Colorectal Cancer.
- Format
- e-Book
- Location
- Online
Immunotherapy for Pediatric Malignancies
https://libcat.nshealth.ca/en/permalink/provcat43239
Juliet C. Gray, Aurélien Marabelle, editors.
--Cham:
Springer
, c2018.
- Available Online
- View e-Book
- Location
- Online
This book provides a comprehensive overview of current immunotherapy strategies, and how these may be applicable to childhood cancers. The first part of the book reviews how the immune system recognizes cancer, and the various escape mechanisms allowing tumour growth. The importance of the tumor microenvironment and the challenges this may present to achieving effective immunotherapy are discussed. Monoclonal antibodies, cellular, cytokine and vaccine therapies are all comprehensively reviewed,…
- Available Online
- View e-Book
- Other Authors
- Gray, Juliet C
- Marabelle, Aurélien
- Responsibility
- Juliet C. Gray, Aurélien Marabelle, editors
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2018
- Physical Description
- 1 online resource (ix, 297 p.) : 29 illus., 27 illus. in color
- ISBN
- 9783319434865
- 9783319434841 (print ed.)
- 9783319434858 (print ed.)
- 9783319828374 (print ed.)
- Subjects (MeSH)
- Antibodies, Monoclonal - therapeutic use
- Child
- Immunotherapy - methods
- Neoplasms - therapy
- Specialty
- Medical Oncology
- Pediatrics
- Regenerative Medicine
- Abstract
- This book provides a comprehensive overview of current immunotherapy strategies, and how these may be applicable to childhood cancers. The first part of the book reviews how the immune system recognizes cancer, and the various escape mechanisms allowing tumour growth. The importance of the tumor microenvironment and the challenges this may present to achieving effective immunotherapy are discussed. Monoclonal antibodies, cellular, cytokine and vaccine therapies are all comprehensively reviewed, with particular focus on their potential application to pediatric cancers. Practical aspects of delivering such therapies to children, likely toxicities and potential biomarkers are considered. Finally, consideration is given to how, in the longer term, such therapies may be combined with conventional therapies such as chemotherapy and radiotherapy. Edited by two distinguished pediatric oncologists with a collection of chapters from the most authoritative experts in cancer immunotherapy, this is an indispensable volume for pediatric oncologists and physicians working in childhood cancer care.
- Contents
- 1. Introduction to Pediatric Cancer Immunotherapy -- 2. Overcoming Immune Suppression in the Tumor Microenvironment: Implications for Multi-modal Therapy -- 3. Allogeneic Stem Cell Transplantation -- 4. Overview of Monoclonal Antibody Therapies -- 5. Monoclonal Antibodies Targeting Hematological Malignancies -- 6. Monoclonal Antibodies Directly Targeting Antigens on Solid Tumours -- 7. Monoclonal Antibodies Targeting the Immune System -- 8. Adoptive T Cell Therapies for Children’s Cancers -- 9. NK Cell and NKT Cell Immunotherapy -- 10. Cancer Vaccines in Pediatrics -- 11. Immune Adjuvants and Cytokine Therapies -- 12. Immune Biomarkers in Paediatric Malignancies -- 13. Future Perspectives.
- Format
- e-Book
- Location
- Online
Personalized Management of Gastric Cancer : Translational and Precision Medicine
https://libcat.nshealth.ca/en/permalink/provcat41986
Jia Wei, Baorui Liu, editors.
--Singapore:
Springer
, 2017.
- Available Online
- View e-Book
- Location
- Online
This book offers essential information on basic and translational research in gastric cancer, while also illustrating potential opportunities for its application in clinical practice. Gastric cancer is the fourth-most-common cancer globally and the second-leading cause of cancer deaths. It is known to be a heterogeneous disease with varied responses to one-size-fits-all treatments. Expanding our knowledge of cancer cell genetics may help us to explore more effective treatments in gastric cancer…
- Available Online
- View e-Book
- Other Authors
- Wei, Jia
- Liu, Baorui
- Responsibility
- Jia Wei, Baorui Liu, editors
- Place of Publication
- Singapore
- Publisher
- Springer
- Date of Publication
- 2017
- Physical Description
- 1 online resource (viii, 227 pages) : 34 illus., 32 illus. in color
- ISBN
- 9789811039782
- 9789811039775 (print ed.)
- Subjects (MeSH)
- Immunotherapy - methods
- Molecular Targeted Therapy - methods
- Nanomedicine - methods
- Precision Medicine - methods
- Stomach Neoplasms - therapy
- Abstract
- This book offers essential information on basic and translational research in gastric cancer, while also illustrating potential opportunities for its application in clinical practice. Gastric cancer is the fourth-most-common cancer globally and the second-leading cause of cancer deaths. It is known to be a heterogeneous disease with varied responses to one-size-fits-all treatments. Expanding our knowledge of cancer cell genetics may help us to explore more effective treatments in gastric cancer. The research on molecular mechanisms and its clinical applications, both presented here, will help readers gain an in-depth understanding of gastric cancer and its effective treatment. The book's four sections cover personalized medicine, precise regional therapy, immunotherapy and nanomedicine in gastric cancer. Each part presents the state of art, recent advances and the authors' experiences. Moreover, several interesting cases are described to demonstrate how gastric cancer patients benefit from translational research. This informative and attractively presented book on precision treatment in gastric cancer, including experimental findings and clinical treatment options, offers a valuable resource for oncologists and graduate students working in the field of gastric cancer. Jia Wei, MD, PhD, is an associate professor at Nanjing University and the vice director of Clinical Cancer Institute of Nanjing University. She is now working as an oncologist in the Comprehensive Cancer Center, Affiliated Drum Tower Hospital to Medical School of Nanjing University. Baorui Liu, MD, PhD, is a professor at Nanjing University and director of the Clinical Cancer Institute of Nanjing University. He is also the director of the Comprehensive Cancer Center of Drum Tower Hospital.
- Contents
- Part I: Personalized Therapy in Gastric Cancer -- Molecular pathology of hereditary gastric cancer -- Genetics and molecular signature of gastric cancer -- Circulating tumor cells in gastric cancer -- Customized chemotherapy in advanced gastric cancer -- Targeted therapy in advanced gastric cancer -- Part II: Precision Regional Therapy in Gastric Cancer -- Laparoscopic surgery and robotic surgery -- Radiotherapy in peritoneal metastatic gastric cancer -- Personalized intraperitoneal strategy in gastric cancer -- Part III: Immunotherapy -- Immune checkpoint blockade therapy of gastric cancer -- Adoptive cell therapy of gastric cancer -- Combinational immunotherapy of gastric cancer -- Part IV: Use of Nanomedicine in the Diagnosis and Treatment of Gastric Cancer -- Use of Nanomedicine in the diagnosis of gastric cancer -- Systemic drug delivery -- Local drug delivery -- Drug delivery in synergistic combination with other treatments.
- Format
- e-Book
- Location
- Online
