Auto-Inflammatory Syndromes : Pathophysiology, Diagnosis, and Management
https://libcat.nshealth.ca/en/permalink/provcat44069
Petros Efthimiou, editor.
--Cham:
Springer
, 2019.
- Available Online
- View e-Book
- Location
- Online
This book provides an overview of auto-inflammatory syndromes, covering the underlying immune mechanisms that lead to their development, specific disease presentations, and clinical treatment guidelines. The book is divided into two sections, adult and pediatric, with chapters focusing on individuals diseases such as systemic arthritis, hyper-IgD, pap syndrome, idiopathic recurrent pericarditis, and familial Mediterranean fever. Chapters incorporate the most recent advances in disease pathophys…
- Available Online
- View e-Book
- Other Authors
- Efthimiou, Petros
- Responsibility
- Petros Efthimiou, editor
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- 2019
- Physical Description
- 1 online resource (xix, 322 p.) : 39 illus., 31 illus. in color
- ISBN
- 9783319969299
- 9783319969282 (Print ed.)
- 9783319969305 (Print ed.)
- Subjects (MeSH)
- Autoimmune Diseases
- Hereditary Autoinflammatory Diseases
- Inflammation - physiopathology
- Specialty
- Allergy and Immunology
- Abstract
- This book provides an overview of auto-inflammatory syndromes, covering the underlying immune mechanisms that lead to their development, specific disease presentations, and clinical treatment guidelines. The book is divided into two sections, adult and pediatric, with chapters focusing on individuals diseases such as systemic arthritis, hyper-IgD, pap syndrome, idiopathic recurrent pericarditis, and familial Mediterranean fever. Chapters incorporate the most recent advances in disease pathophysiology and examine the underlying inductive and effector mechanisms and therapies that relate to each auto-inflammatory disorder at the genetic, molecular, cellular, and epidemiologic levels. The book also discusses the research behind auto-inflammatory disorders to offer detailed clinical guidelines regarding diagnostic techniques, treatment plans, and advice on how to best transition pediatric patients into adult treatment. This is an invaluable reference on auto-inflammatory syndromes for clinicians and researchers in pediatric and adult rheumatology and immunology.
- Contents
- 1. Immunology of Auto-inflammatory Syndromes -- Part I. Monogenic Autoinflammatory Diseases -- 2. Mevalonate Kinase Deficiency (MKD)/Hyperimmunoglobulin D Syndrome (HIDS) -- 3. The TNF Receptor-Associated Autoinflammatory Syndrome (TRAPS) -- 4. PAPA Syndrome and the Spectrum of PSTPIP1-Associated Inflammatory Diseases -- 5. Blau Syndrome -- 6. Deficiency of the Interleukin-1 Receptor Antagonist (DIRA) -- 7. Deficiency of the Interleukin-36 Receptor Antagonist (DITRA) and Generalized Pustular Psoriasis -- 8. Cryopyrin-Associated Periodic Syndromes (CAPS) -- 9. Familial Mediterranean Fever -- 10. Type I Interferonopathies: From Pathophysiology to Clinical Expression -- 11. Deficiency of Adenosine Deaminase 2 (DADA2) -- 12. Yao Syndrome -- Part II. Polygenic Autoinflammatory Diseases -- 13. Systemic Juvenile Idiopathic Arthritis -- 14. Macrophage Activation Syndrome (MAS) -- 15. Schnitzler Syndrome -- 16. Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis (PFAPA) Syndrome -- 17. Chronic Nonbacterial Osteomyelitis -- 18. Improving the Transition from Pediatric to Adult Care for Adolescents and Young Adults with Autoinflammatory Diseases -- 19. Adult-Onset Still’s Disease - 20. Idiopathic Recurrent Acute Pericarditis -- 21. Adamantiades-Behçet’s Disease -- 22. Amyloidosis.
- Format
- e-Book
- Location
- Online
Autophagy Networks in Inflammation
https://libcat.nshealth.ca/en/permalink/provcat40154
Maria Chiara Maiuri, Daniela De Stefano, editors.
--Cham:
Springer
, c2016.
- Available Online
- View e-Book
- Location
- Online
Autophagy principally serves an adaptive function to protect organisms against diverse human pathologies, including cancer and neurodegeneration. Recent developments using in vitro, ex vivo and in vivo models show the involvement of the autophagy pathway in immunity and inflammation. Moreover, direct interactions between autophagy proteins and immune signalling molecules have also been demonstrated. Defects in autophagy - similar to cancer, neurodegenerative diseases and aging - through autopha…
- Available Online
- View e-Book
- Other Authors
- Maiuri, Maria Chiara
- De Stefano, Daniela
- Responsibility
- Maria Chiara Maiuri, Daniela De Stefano, editors
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2016
- Physical Description
- 1 online resource (xv, 403 p. : 20 illus., 16 illus. in color)
- Series Title
- Progress in inflammation research
- ISBN
- 9783319300795
- 9783319300771 (print ed.)
- Subjects (MeSH)
- Autophagy
- Inflammasomes
- Inflammation - physiopathology
- Inflammation - therapy
- Abstract
- Autophagy principally serves an adaptive function to protect organisms against diverse human pathologies, including cancer and neurodegeneration. Recent developments using in vitro, ex vivo and in vivo models show the involvement of the autophagy pathway in immunity and inflammation. Moreover, direct interactions between autophagy proteins and immune signalling molecules have also been demonstrated. Defects in autophagy - similar to cancer, neurodegenerative diseases and aging - through autophagy gene mutation and/or microbial antagonism, may underlie the pathogenesis of many infectious diseases and inflammatory syndromes. In spite of the increasing awareness of the importance of autophagy in these pathophysiological conditions, this process remains underestimated and is often overlooked. As a consequence, its role in the initiation, stability, maintenance, and progression of these diseases are still poorly understood. This book reviews the recent advances regarding the functions of the autophagy pathway and autophagy proteins in immunity and inflammation, focusing on their role in self-nonself distinction, their implications in innate and adaptive immune responses and their dysregulation in the pathology of certain inflammatory and autoimmune diseases.
- Contents
- [publisher supplied] Autophagy in direct pathogen elimination (Xenophagy) -- Autophagy and pattern recognition receptors -- Autophagy and inflammasomes -- Autophagy and Antigen presentation -- Autophagy and regulation of T and B cell function -- Autophagy in chronic inflammation -- The complex crosstalk between autophagy and ROS -- Lipophagy -- Autophagy, phagocytosis and entosis: who eats whom? -- Which is the cell fate of inflammatory cells? Autophagic cell death, pyroptosis, netosis, apoptosis, necrosis -- Host defence (virus/bacteria) -- Neurological diseases -- Pulmonary diseases (emphysema, COPD, etc.) -- Inflammatory bowel disease -- Target autophagy as a novel therapeutic strategy in autoimmune diseases -- Liver and pancreatic diseases -- Obesity -- Aging -- Overview on clinical trials.
- Format
- e-Book
- Location
- Online
The biology of human longevity : inflammation, nutrition, and aging in the evolution of lifespans
https://libcat.nshealth.ca/en/permalink/provcat27590
Finch, Caleb E.
--Amsterdam, Netherlands:
Elsevier Academic Press
, 2007.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Author
- Finch, Caleb E
- Place of Publication
- Amsterdam, Netherlands
- Publisher
- Elsevier Academic Press
- Date of Publication
- 2007
- Physical Description
- 626 p.
- ISBN
- 9780080545943
- Subjects (MeSH)
- Longevity - physiology
- Aging - physiology
- Inflammation
- Nutritional Physiological Phenomena
- Contents
- 1. INFLAMMATION AND OXIDATION IN AGING AND CHRONIC DISEASES. 1.1. Overview ; 1.2. Experimental models for aging ; 1.3. Outline of inflammation ; 1.4. Bystander damage and dependent variables in senescence ; 1.5 Arterial aging and atherosclerosis ; 1.6. Alzheimer disease and vascular-related dementias ; 1.7. Inflammation in obesity ; 1.8. Processes of normal aging in the absence of specific diseases ; 1.9. Summary -- 2. INFECTIONS, INFLAMMOGENS, AND DRUGS. 2.1. Introduction ; 2.2. Vascular disease ; 2.3. Infections from the central tube : Metchnikoff revisited ; 2.4. Aerosols and dietary inflammogens ; 2.5. Infections, inflammation, and life span ; 2.6. Are infections a cause of obesity? ; 2.7. Inflammation, dementia, and cognitive decline ; 2.8. Immunosenescence and stem cells ; 2.9. Cancer, infection, and inflammation ; 2.10. Pharmacopleiotropies in vascular disease, dementia, and cancer ; 2.11. Summary -- 3. ENERGY BALANCE, INFLAMMATION, AND AGING. 3.1. Introduction ; 3.2. Diet restriction and aging ; 3.3. Energy sensing in diet restriction and satiety ; 3.4. Exercise, cardiovascular health, and longevity ; 3.5. Diet, exercise, and neurodegeneration ; 3.6. Laboratory rodents as models for the 'couch potato' ; 3.7. Energy balance in the life history ; 3.8. Summary -- 4. NUTRITION AND INFECTION IN THE DEVELOPMENTAL INFLUENCES ON AGING. 4.1. Introduction ; 4.2. Synopsis of the fetal origins theory ; 4.3. The Barker studies of infections and vascular disease ; 4.4. Size, health, and longevity ; 4.5. Infection and undernutrition on birthweight and later disease ; 4.6. Infection and nutrition in postnatal development and later disease ; 4.7. Famine ; 4.8. Maternal physiology, fetal growth, and later chronic disease ; 4.9. Growth in adaptive responses to the environment ; 4.10. Genomics of fetal growth regulation ; 4.11. Summary -- 5. GENETICS. 5.1. Introduction ; 5.2. Sources of individual variations in aging and life span ; 5.3. Sex differences in longevity ; 5.4. Metabolism and host-defense in worm and fly ; 5.5. The worm ; 5.6. Fly ; 5.7. Mammals ; 5.8. Summary -- 6. THE HUMAN LIFE SPAN : PRESENT, PAST, AND FUTURE. 6.1. Introduction ; 6.2. From great ape to human ; 6.3. Four major shifts in human life history from genetic and cultural evolution ; 6.4. The instability of life spans ; 6.5. Summary of chapters 1-6 : mechanisms in aging and life history evolution.
- Format
- e-Book
- Location
- Online
Biomarkers of Cardiometabolic Risk, Inflammation and Disease
https://libcat.nshealth.ca/en/permalink/provcat39237
Filipe Palavra, Fl©vio Reis, Daniela Marado, Armando Sena, editors.
--Cham:
Springer
, c2015.
- Available Online
- View e-Book
- Location
- Online
This book discusses recent advances in the area of cardiometabolic risk biomarkers of chronic inflammatory and cardiovascular disorders. Tackling the topic in a systematic manner, the book starts with an introduction to cardiometabolic risk and its clinical relevance, comparing emergent and classical biomarkers. It then goes on to discuss cardiometabolic risk biomarkers in a range of diseases, including diabetes, ischemic stroke and neurodegenerative disorders. Biomarkers of Cardiometabolic Ris…
- Available Online
- View e-Book
- Other Authors
- Palavra, Filipe
- Reis, Fl©vio
- Marado, Daniela
- Sena, Armando
- Responsibility
- Filipe Palavra, Fl©vio Reis, Daniela Marado, Armando Sena, editors
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2015
- Physical Description
- 1 online resource (x, 165 p. : 11 illus. in color)
- ISBN
- 9783319160184
- 9783319160177 (print ed.)
- Subjects (MeSH)
- Biomarkers
- Cardiovascular Diseases - diagnosis
- Inflammation
- Risk Factors
- Abstract
- This book discusses recent advances in the area of cardiometabolic risk biomarkers of chronic inflammatory and cardiovascular disorders. Tackling the topic in a systematic manner, the book starts with an introduction to cardiometabolic risk and its clinical relevance, comparing emergent and classical biomarkers. It then goes on to discuss cardiometabolic risk biomarkers in a range of diseases, including diabetes, ischemic stroke and neurodegenerative disorders. Biomarkers of Cardiometabolic Risk, Inflammation and Disease is aimed at doctors specializing in internal medicine, neurology, cardiology, rheumatology, nephrology or endocrinology and will also be of interest to GPs, trainee doctors, and clinical and basic researchers working on cardiovascular and autoimmune disorders.
- Contents
- Inflammation biomarkers and cardiometabolic risk -- Cardiovascular disease -- Diabetes mellitus and metabolic syndrome -- Ischemic stroke -- Chronic kidney disease -- Immune-mediated inflammatory rheumatic diseases -- Cardiometabolic risk, inflammation and neurodegenerative disorders.
- Format
- e-Book
- Location
- Online
The Blood Brain Barrier and Inflammation
https://libcat.nshealth.ca/en/permalink/provcat41542
Ruth Lyck, Gaby Enzmann, editors.
--Cham:
Springer
, 2017.
- Available Online
- View e-Book
- Location
- Online
Within the central nervous system (CNS) the constantly changing blood stream is separated from the CNS parenchyma by the blood brain barrier (BBB) restricting passage to selected immune cells. Under pathological conditions, however, viruses, bacteria, parasites and autoaggressive immune cells can penetrate the barrier and contribute to CNS inflammation. The BBB actively contributes to neuroinflammation by presentation of chemokines, expression of cell adhesion molecules and alteration of barrie…
- Available Online
- View e-Book
- Other Authors
- Lyck, Ruth
- Enzmann, Gaby
- Responsibility
- Ruth Lyck, Gaby Enzmann, editors
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- 2017
- Physical Description
- 1 online resource (vi, 286 pages) : 32 illus., 24 illus. in color
- Series Title
- Progress in inflammation research
- ISBN
- 9783319455143
- 9783319455129 (print ed.)
- Subjects (MeSH)
- Blood-Brain Barrier - physiopathology
- Central Nervous System Diseases - metabolism
- Models, Animal
- Neurogenic Inflammation - metabolism
- Abstract
- Within the central nervous system (CNS) the constantly changing blood stream is separated from the CNS parenchyma by the blood brain barrier (BBB) restricting passage to selected immune cells. Under pathological conditions, however, viruses, bacteria, parasites and autoaggressive immune cells can penetrate the barrier and contribute to CNS inflammation. The BBB actively contributes to neuroinflammation by presentation of chemokines, expression of cell adhesion molecules and alteration of barrier properties. As such, understanding the role of the BBB under healthy and pathological conditions is essential for the development of new drugs to efficiently combat inflammatory diseases of the CNS. This book presents a comprehensive collection of reviews that focus on the role of the BBB. Experts in the field share their insight on structural, topological and functional properties of the BBB. They elaborate on pathophysiological changes of the inflamed BBB such as permeability, transporter proteins and alterations in microRNAs and cytokine profile. Additional chapters on multiple sclerosis and bacterial meningitis provide in depth information on significant neuroinflammatory diseases. The selection is complemented by a review on the current understanding of the BBB as signaling hub in tumor pathogenesis in the brain.
- Contents
- General Introduction to Barrier Mechanisms in the Central Nervous System -- Topological Aspects of the Blood-Brain and Blood-Cerebrospinal Fluid Barriers and their Relevance in Inflammation Research -- The Contribution of the Extracellular Matrix to the BBB in Steady State and Inflammatory Conditions -- Pathophysiology of the Bloodbrain Barrier in Neuroinflammatory Diseases -- Leakage at Blood-neural Barriers -- Blood-Brain Barrier Transporters and Neuroinflammation: Partners in Neuroprotection and in Pathology -- MicroRNAs in Brain Endothelium and Inflammation -- Blood-Brain Barrier Dysfunction during Central Nervous System Autoimmune Diseases -- Pathways Across the Blood Brain Barrier -- Neuroinflammation in Bacterial Meningitis -- Blood Vessels in the Brain: a Signaling Hub in Brain Tumor Inflammation.
- Format
- e-Book
- Location
- Online
A Clinician's Guide to Systemic Effects of Periodontal Diseases
https://libcat.nshealth.ca/en/permalink/provcat40380
Ronald G. Craig, Angela R. Kamer, editors.
--Berlin, Heidelberg:
Springer
, c2016.
- Available Online
- View e-Book
- Location
- Online
A Clinician's Guide to Systemic Effects of Periodontal Diseases will serve as an ideal, easy-to-use reference for the practicing health professional. It summarizes the latest research on the systemic effects of periodontal diseases, discusses how the results of this research will impact on clinical practice, and aims to help the clinician to answer questions that may be posed by patients, medical colleagues, and the media. A central theme is the contribution of periodontal diseases to systemic …
- Available Online
- View e-Book
- Other Authors
- Craig, Ronald G
- Kamer, Angela R
- Responsibility
- Ronald G. Craig, Angela R. Kamer, editors
- Place of Publication
- Berlin, Heidelberg
- Publisher
- Springer
- Date of Publication
- c2016
- Physical Description
- 1 online resource (viii, 124 p. : 11 illus., 7 illus. in color)
- ISBN
- 9783662496992
- 9783662496978 (print ed.)
- Subjects (MeSH)
- Comorbidity
- Inflammation
- Periodontal Diseases - complications
- Abstract
- A Clinician's Guide to Systemic Effects of Periodontal Diseases will serve as an ideal, easy-to-use reference for the practicing health professional. It summarizes the latest research on the systemic effects of periodontal diseases, discusses how the results of this research will impact on clinical practice, and aims to help the clinician to answer questions that may be posed by patients, medical colleagues, and the media. A central theme is the contribution of periodontal diseases to systemic inflammation but other mechanisms, such as systemic dissemination of oral pathogens, are also covered. The associations between periodontitis and a variety of conditions, including diabetes mellitus, atherosclerotic complications, chronic kidney disease, pulmonary infections, and Alzheimer's disease, are carefully documented. Importantly, a collaborative approach involving noted investigators in each field and medical colleagues ensures that all chapters are of clinical relevance from both a dental and a medical perspective. The book is also visually engaging, with numerous summary figures and graphics, bullet point tables, and highlight boxes identifying the most clinically significant points.
- Contents
- 1. Introduction and Overview of the Systemic Effects of Periodontal Diseases -- 2. Pathogenesis of Periodontal Diseases -- 3. Periodontitis and Diabetes Mellitus: A Complex Relationship -- 4. Atherosclerotic Vascular Disease and Periodontal Disease -- 5. Interactions Between Periodontal Disease and Chronic Kidney Diseases -- 6. The Association Between Periodontitis and Preterm Labor (PTL) -- 7. Oral Health and Pneumonia -- 8. Peripheral Inflammation and Alzheimer’s Disease: Periodontal Disease -- 9. Periodontal Infections and Rheumatoid Arthritis -- 10. Summary and Possible Future Directions.
- Format
- e-Book
- Location
- Online
Cytokines as Potential Therapeutic Targets for Inflammatory Skin Diseases
https://libcat.nshealth.ca/en/permalink/provcat29985
edited by R. Numerof, C. A. Dinarello, K. Asadullah.
--Berlin, Heidelberg:
Springer-Verlag
, c2006.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Author
- Numerof, R
- Other Authors
- Dinarello, C. A
- Asadullah, K
- Responsibility
- edited by R. Numerof, C. A. Dinarello, K. Asadullah
- Place of Publication
- Berlin, Heidelberg
- Publisher
- Springer-Verlag
- Date of Publication
- c2006
- Series Vol.
- 56
- Series Title
- Ernst Schering Research Foundation workshop
- ISBN
- 9783540376736
- Subjects (MeSH)
- Cytokines - antagonists & inhibitors
- Inflammation - therapy
- Skin Diseases - immunology
- Skin Diseases - physiopathology
- Subjects (LCSH)
- Immunology
- Dermatology
- Biochemistry
- Format
- e-Book
- Location
- Online
Endothelial Dysfunction and Inflammation
https://libcat.nshealth.ca/en/permalink/provcat28152
edited by Shauna Dauphinee, Aly Karsan.
--Basel:
Springer Basel AG
, c2010.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Author
- Dauphinee, Shauna
- Other Authors
- Karsan, Aly
- Responsibility
- edited by Shauna Dauphinee, Aly Karsan
- Place of Publication
- Basel
- Publisher
- Springer Basel AG
- Date of Publication
- c2010
- Series Title
- Progress in inflammation research
- ISBN
- 9783034601689
- Subjects (MeSH)
- Endothelial Cells - pathology
- Endothelium, Vascular - physiopathology
- Inflammation - physiopathology
- Subjects (LCSH)
- Biochemistry
- Cytology
- Format
- e-Book
- Location
- Online
Genitourinary Pain And Inflammation : Diagnosis And Management
https://libcat.nshealth.ca/en/permalink/provcat30474
edited by Jeannette M. Potts.
--Totowa, NJ:
Humana Press
, c2008.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Author
- Potts, Jeannette M
- Responsibility
- edited by Jeannette M. Potts
- Place of Publication
- Totowa, NJ
- Publisher
- Humana Press
- Date of Publication
- c2008
- Series Title
- Current clinical urology
- ISBN
- 9781603271264
- Subjects (MeSH)
- Female Urogenital Diseases
- Male Urogenital Diseases
- Inflammation
- Pelvic Pain - diagnosis
- Pelvic Pain - therapy
- Subjects (LCSH)
- Urology
- Format
- e-Book
- Location
- Online
Hemosiderin staining
https://libcat.nshealth.ca/en/permalink/chpams38204
Nova Scotia Health Authority. Eastern Memorial Hospital. Foot Clinic.
Halifax, NS:
Nova Scotia Health Authority
, 2023.
- Pamphlet Number
- 2352
- Available Online
- View Pamphlet
This pamphlet explains what hemosiderin staining is and its causes. A list of what makes some people at a higher risk for hemosiderin staining is given. Treatment is also explained.
- Available Online
- View Pamphlet
- Corporate Author
- Nova Scotia Health Authority. Eastern Memorial Hospital. Foot Clinic
- Place of Publication
- Halifax, NS
- Publisher
- Nova Scotia Health Authority
- Date of Publication
- 2023
- Format
- Pamphlet
- Language
- English
- Physical Description
- 1 electronic document ([2] p.) : digital, PDF file
- Subjects (MeSH)
- Pigments, Biological
- Leg
- Dermatitis
- Subjects (LCSH)
- Skin--Inflammation
- Pigments
- Leg
- Specialty
- Muscoskeletal System
- Abstract
- This pamphlet explains what hemosiderin staining is and its causes. A list of what makes some people at a higher risk for hemosiderin staining is given. Treatment is also explained.
- Responsibility
- Prepared by: Foot Clinic, Eastern Memorial Hospital
- Pamphlet Number
- 2352
IL-17, IL-22 and their producing cells : role in inflammation and autoimmunity
https://libcat.nshealth.ca/en/permalink/provcat32482
Valérie Quesniaux, Bernhard Ryffel, Franco Padova, editors.
(2nd ed.)
--Basel:
Springer
, c2013.
- Available Online
- View e-Book
- Location
- Online
The knowledge of Th17 cells and other cell populations which secrete IL-17A, and/or IL-22 has expanded tremendously since the publication of the first edition "Th17 Cells: Role in Inflammation and Autoimmune Disease" in 2008. The present volume has been completely revised with the addition of new chapters on the IL-17 receptor family and signaling, and an in-depth review of IL-22 and innate lymphoid cells. The differentiation of naive T cells into regulatory T cells and Th17 cells as well as th…
- Available Online
- View e-Book
- Other Authors
- Quesniaux, Valérie
- Ryffel, Bernhard
- Padova, Franco
- Responsibility
- Valérie Quesniaux, Bernhard Ryffel, Franco Padova, editors
- Edition
- 2nd ed.
- Place of Publication
- Basel
- Publisher
- Springer
- Date of Publication
- c2013
- Physical Description
- 1 online resource (ix, 354 p. : 25 ill., 14 ill. in color)
- Series Title
- Progress in inflammation research
- ISBN
- 9783034805223
- Subjects (MeSH)
- Immunity, Cellular - physiology
- Inflammation - physiopathology
- Interleukin-17 - immunology
- Interleukins - immunology
- Subjects (LCSH)
- Oncology
- Immunology
- Infectious diseases
- Cell receptors
- Cytokines
- Cytology
- Abstract
- The knowledge of Th17 cells and other cell populations which secrete IL-17A, and/or IL-22 has expanded tremendously since the publication of the first edition "Th17 Cells: Role in Inflammation and Autoimmune Disease" in 2008. The present volume has been completely revised with the addition of new chapters on the IL-17 receptor family and signaling, and an in-depth review of IL-22 and innate lymphoid cells. The differentiation of naive T cells into regulatory T cells and Th17 cells as well as the plasticity of Th17 cells is discussed. The role of IL-22 in cutaneous inflammation including psoriasis has been reviewed. In addition, the volume contains critical updates on autoimmunity, organ transplantation, tumor immunology and genetic mouse models for mechanistic studies. Lastly, the latest clinical progress in neutralizing antibodies to IL-17A, IL-17RA not only confirms the therapeutic promise foreseen in 2008, but also improves our knowledge of the pathogenesis of autoimmune diseases. In summary, this is a timely update and important review of the clinical and experimental aspects of IL-17, IL-22 and their producing cells.
- Contents
- IL-17A family, receptors, proinflammatory effects and production -- IL-22 and IL-17 overview -- IL-17R family: Structure, signal transduction and function -- Contribution of IL-22 to Th17 responses: repairing and protecting peripheral tissues -- Central role of Th-17 cells in adaptive immune responses -- Regulatory T cells vs Th17: Differentiation of Th17 versus Treg are they mutually exclusiveáOther sources of IL-17: iNKT cells -- Retinoic acid in mucosal immune regulation -- Critical role of IL-17 in experimental arthritis -- Dual role IL-17A, F and IL-22 in allergic asthma -- Inflammasome - IL-1 - IL-17 response in lung inflammation -- The role of Il-17 in exp autoimmune mycocarditis -- Th17 cells in transplantation: actors or innocent bystanders -- Is IL-17 required to control of tuberculosisáIL-17 and mucosal host defense. Role of IL-17 and IL-17 family cytokines on tumor development -- IL-17 and TH17 cells in rheumatoid arthritis and other inflammatory conditions -- Targeting Th17 Cells for therapy of multiple sclerosis -- Involvement of interleukin-17 cytokines in human asthma -- IL-17 and/or IL-22 as potential target(s) for Crohn's disease -- Role of IL-23, IL-17 and IL-22 in psoriasis -- Contribution of IL-22 to experimental skin inflammation -- Genetic mouse models to investigate IL-17 responses -- IL-17A as a therapeutic target for autoimmune diseases -- Index.
- Format
- e-Book
- Location
- Online
Immune modulation and anti-inflammatory therapy in ocular disorders : IOIS guidelines
https://libcat.nshealth.ca/en/permalink/provcat34026
Uwe Pleyer, Jorge L. Alió, Talin Barisani-Asenbauer, Phuc Le Hoang, Narsing A. Rao, editors.
--Heidelberg:
Springer
, c2014.
- Available Online
- View e-Book
- Location
- Online
These guidelines, compiled by a panel of clinicians and scientists with a high level of expertise, aim to provide readers with the most up-to-date and comprehensive instructions on the treatment and prevention of ocular inflammation. All of the recommendations are explicitly linked to supporting evidence and graded according to the strength of that evidence, and the editors have made every effort to ensure that chapters are of a consistently high methodological quality. The guidelines for each …
- Available Online
- View e-Book
- Corporate Author
- International Ocular Inflammation Society
- Other Authors
- Pleyer, Uwe
- Responsibility
- Uwe Pleyer, Jorge L. Alió, Talin Barisani-Asenbauer, Phuc Le Hoang, Narsing A. Rao, editors
- Place of Publication
- Heidelberg
- Publisher
- Springer
- Date of Publication
- c2014
- Physical Description
- 1 online resource (xiii, 244 pages)
- ISBN
- 9783642543500 (electronic bk.)
- 9783642543494
- Subjects (MeSH)
- Eye Diseases - immunology
- Immunomodulation - drug effects
- Immunosuppression - methods
- Immunosuppressive Agents - therapeutic use
- Inflammation - drug therapy
- Subjects (LCSH)
- Eye - Diseases
- Eye - Diseases - Immunological aspects
- Abstract
- These guidelines, compiled by a panel of clinicians and scientists with a high level of expertise, aim to provide readers with the most up-to-date and comprehensive instructions on the treatment and prevention of ocular inflammation. All of the recommendations are explicitly linked to supporting evidence and graded according to the strength of that evidence, and the editors have made every effort to ensure that chapters are of a consistently high methodological quality. The guidelines for each treatment include dose and the frequency and mode of delivery. Significant side-effects of treatment are identified and distinguished from those of the disease in question. Suggestions are presented for the prevention both of the disease itself and of the treatment-related complications. In addition, likely future directions in treatment and prevention are identified.
- Contents
- Ocular Allergy -- Immune Modulation in Ocular Mucous Membrane Pemphigoid -- Diagnosis and Management of Scleritis -- Noninfectious Inflammation in Cataract Surgery -- Corneal Inflammation Following Excimer Laser Surgery -- Prevention and Treatment of Transplant Rejection in Keratoplasty -- Immunomodulation Against Inflammatory Postkeratoplasty Neovascularisation -- Treatment of Inflammation Secondary to Vitreoretinal Surgery -- Treatment of Intermediate Uveitis -- Posterior Uveitis -- Cystoid Macular Edema -- Safety of Immunosuppressive Therapy for Eye Diseases.
- Format
- e-Book
- Location
- Online
Immunotherapy in 2020 : Visions and Trends for Targeting Inflammatory Disease
https://libcat.nshealth.ca/en/permalink/provcat40598
A. Radbruch, H.-D. Volk, K. Asadullah, W.-D. Doecke, editors.
--Berlin, Heidelberg:
Springer
, c2007.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Other Authors
- Radbruch, A (Andreas)
- Responsibility
- A. Radbruch, H.-D. Volk, K. Asadullah, W.-D. Doecke, editors
- Place of Publication
- Berlin, Heidelberg
- Publisher
- Springer
- Date of Publication
- c2007
- Physical Description
- 1 online resource (xiii, 106 p.)
- Series Vol.
- 2006/4
- Series Title
- Ernst Schering Foundation Symposium Proceedings
- ISBN
- 9783540708513
- 9783540708506 (print ed.)
- ISSN
- 0947-6075
- Subjects (MeSH)
- Immunotherapy - trends
- Inflammation - therapy
- Contents
- Nature's Choice of Genes Controlling Chronic Inflammation -- Targeting of Memory -- Post-transcriptional Regulators in Inflammation: Exploring New Avenues in Biological Therapeutics -- Immunomodulatory Therapies: Challenges of Individualized Therapy Strategies -- T Cell Therapies -- The Future of Antibody Therapy.
- Format
- e-Book
- Publication Type
- Congress
- Location
- Online
The Inflammasomes
https://libcat.nshealth.ca/en/permalink/provcat28072
edited by Isabelle Couillin, Virginie Pétrilli, Fabio Martinon.
--Basel:
Springer Basel AG
, c2011.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Author
- Couillin, Isabelle
- Other Authors
- Pétrilli, Virginie
- Martinon, Fabio
- Responsibility
- edited by Isabelle Couillin, Virginie Pétrilli, Fabio Martinon
- Place of Publication
- Basel
- Publisher
- Springer Basel AG
- Date of Publication
- c2011
- Series Title
- Progress in inflammation research
- ISBN
- 9783034801485
- Subjects (MeSH)
- Inflammasomes
- Inflammation Mediators
- Subjects (LCSH)
- Biochemistry
- Immunology
- Format
- e-Book
- Location
- Online
Inflammation and Gastrointestinal Cancers
https://libcat.nshealth.ca/en/permalink/provcat28687
edited by Janusz A. Z. Jankowski.
--Berlin, Heidelberg:
Springer-Verlag
, c2011.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Author
- Jankowski, Janusz A. Z
- Responsibility
- edited by Janusz A. Z. Jankowski
- Place of Publication
- Berlin, Heidelberg
- Publisher
- Springer-Verlag
- Date of Publication
- c2011
- Series Vol.
- 185
- Series Title
- Recent results in cancer research
- ISBN
- 9783642035036
- Subjects (MeSH)
- Gastrointestinal Neoplasms - etiology
- Inflammation - complications
- Subjects (LCSH)
- Gastroenterology
- Oncology
- Format
- e-Book
- Location
- Online
Inflammation in Parkinson's disease : scientific and clinical aspects
https://libcat.nshealth.ca/en/permalink/provcat34054
Madhavi Thomas, editor.
--Cham, Switzerland:
Springer
, c2014.
- Available Online
- View e-Book
- Location
- Online
Inflammation in Parkinson's Disease brings advances in research together with current literature and evidence. This concise volume covers the fundamentals of neuroimmunology and inflammatory models, the interactions between pathways of neurodegeneration and follows the concept of research work undertaken from basic science to clinical trials. Researchers, clinicians, and students interested in Parkinson's Disease are provided with a comprehensive view of translational research methods and an in…
- Available Online
- View e-Book
- Other Authors
- Thomas, Madhavi
- Responsibility
- Madhavi Thomas, editor
- Place of Publication
- Cham, Switzerland
- Publisher
- Springer
- Date of Publication
- c2014
- Physical Description
- 1 online resource (xvi, 222 pages)
- ISBN
- 9783319080468 (electronic bk.)
- 3319080466 (electronic bk.)
- 3319080458 (print)
- 9783319080451 (print)
- Subjects (MeSH)
- Inflammation
- Parkinson Disease
- Subjects (LCSH)
- Parkinson's disease
- Inflammation
- Neurology
- Immunology
- Abstract
- Inflammation in Parkinson's Disease brings advances in research together with current literature and evidence. This concise volume covers the fundamentals of neuroimmunology and inflammatory models, the interactions between pathways of neurodegeneration and follows the concept of research work undertaken from basic science to clinical trials. Researchers, clinicians, and students interested in Parkinson's Disease are provided with a comprehensive view of translational research methods and an insight needed for developing future therapies aimed at disease modulation.
- Contents
- Parkinson’s Disease: An Overview of Etiology, Clinical Manifestations, and Treatment -- Neuropathology of Parkinson’s Disease -- Role of the Innate and Adaptive Immune System in the Pathogenesis of PD -- “Good” and “Bad” Microglia in Parkinson’s Disease: An Understanding of Homeostatic Mechanisms in Immunomodulation -- The Role of Astrocytes in Parkinson’s Disease -- Proinflammatory Chemical Signaling: Cytokines -- Cell Culture Models of Inflammation in Parkinson’s Disease -- Clinical Aspects of Inflammation in Parkinson’s Disease -- PET Imaging in Neuroinflammation.
- Format
- e-Book
- Location
- Online
Inflammatory and Infectious Ocular Disorders
https://libcat.nshealth.ca/en/permalink/provcat44879
Hyeong Gon Yu, editor.
--Singapore:
Springer
, c2020.
- Available Online
- View e-Book
- Location
- Online
This atlas covers most ocular inflammatory and infectious diseases of importance with clinical significance. It includes chapters on non-infectious diseases and chapters on infectious diseases. For each chapter, essential information regarding the clinical features, diagnosis, and management is described in the text based on the up-to-date knowledge, and more than 240 carefully selected photographs are provided. World-famous experts in this field have included as many as valuable photographs of…
- Available Online
- View e-Book
- Other Authors
- Yu, Hyeong Gon
- Responsibility
- Hyeong Gon Yu, editor
- Place of Publication
- Singapore
- Publisher
- Springer
- Date of Publication
- c2020
- Physical Description
- 1 online resource (vii, 220 p.) : 240 illus., 192 illus. in color
- Series Vol.
- 5
- Series Title
- Retina atlas
- ISBN
- 9789811385469
- 9789811385452 (Print ed.)
- 9789811385476 (Print ed.)
- 9789811385483 (Print ed.)
- ISSN
- 2662-5741
- Subjects (MeSH)
- Eye Infections
- Inflammation
- Specialty
- Infectious Disease Medicine
- Ophthalmology
- Abstract
- This atlas covers most ocular inflammatory and infectious diseases of importance with clinical significance. It includes chapters on non-infectious diseases and chapters on infectious diseases. For each chapter, essential information regarding the clinical features, diagnosis, and management is described in the text based on the up-to-date knowledge, and more than 240 carefully selected photographs are provided. World-famous experts in this field have included as many as valuable photographs of patients as possible. New imaging tests of ultra-wide field retinal images and high-resolution optical coherence tomography are included in addition to conventional fundus photos and fluorescein angiographs. Especially, chapters on infectious diseases provide invaluable photos of rare but clinically important diseases. Designed to assist in the diagnosis and treatment of ocular inflammation and infection, this book is meant for the retina specialist, researchers of ocular inflammation, general ophthalmologist, resident and retina fellow. Inflammatory and Infectious Ocular Disorders atlas is one of the nine volumes of the series Retina Atlas. This series provides global perspective on vitreoretinal diseases, covering imaging basics, retinal vascular disease, macular disorders, ocular inflammatory and infectious disorders, retinal degeneration, surgical retina, ocular oncology, pediatric retina and trauma. This comprehensive atlas is spread over 9 volumes and about 100 chapters, covering validated and comprehensive information on retinal disorders.
- Contents
- Acute posterior multifocal placoid pigment epitheliopathy -- Serpiginous choroiditis -- Punctate inner choroidopathy -- Multifocal choroiditis with panuveitis -- Multiple evanescent white dot syndrome -- Acute zonal occult outer retinopathy -- Birdshot retinochoroidopathy -- Sympathetic ophthalmia -- Vogt-Koyanagi-Harada disease -- Intermediate uveitis -- Sarcoidosis -- Behcet disease -- Systemic lupus erythematosus -- Posterior scleritis -- Autoimmune retinopathy -- Ocular tuberculosis 1 -- Ocular tuberculosis 2 -- Cat-scratch disease -- Retinal and optic nerve involvement in syphilis -- Leptospirosis -- Fungal diseases -- Toxoplasmosis -- Toxocariasis -- Ocular cysticercosis -- Diffuse unilateral subacute neuroretinitis -- Human immunodeficiency virus infection and cytomegalovirus retinitis -- Acute retinal necrosis and progressive outer retinal necrosis.
- Format
- e-Book
- Publication Type
- Atlas
- Location
- Online
Inflammatory Arthritis in Clinical Practice
https://libcat.nshealth.ca/en/permalink/provcat38905
Ian C. Scott, James B. Galloway, David L. Scott.
(2nd ed.)
--London:
Springer
, c2015.
- Available Online
- View e-Book
- Location
- Online
This evidence based book covers the key components in the diagnosis, assessment and management of inflammatory arthritis. The authors look at the epidemiology, pathology, clinical assessment and investigation of inflammatory arthritis patients, and provide an overview of currently available treatment options. With major changes seen in the way inflammatory arthropathies are diagnosed, classified, investigated and managed, Inflammatory Arthritis in Clinical Practice, Second Edition provides the …
- Available Online
- View e-Book
- Author
- Scott, Ian C
- Other Authors
- Galloway, James B
- Scott, David L
- Responsibility
- Ian C. Scott, James B. Galloway, David L. Scott
- Edition
- 2nd ed.
- Place of Publication
- London
- Publisher
- Springer
- Date of Publication
- c2015
- Physical Description
- 1 online resource (xviii, 214 p. : 36 illus., 27 illus. in color)
- ISBN
- 9781447166481
- 9781447166474 (print ed.)
- Subjects (MeSH)
- Anti-Inflammatory Agents - therapeutic use
- Antirheumatic Agents - therapeutic use
- Arthritis, Rheumatoid - drug therapy
- Inflammation - drug therapy
- Spondylarthritis - drug therapy
- Abstract
- This evidence based book covers the key components in the diagnosis, assessment and management of inflammatory arthritis. The authors look at the epidemiology, pathology, clinical assessment and investigation of inflammatory arthritis patients, and provide an overview of currently available treatment options. With major changes seen in the way inflammatory arthropathies are diagnosed, classified, investigated and managed, Inflammatory Arthritis in Clinical Practice, Second Edition provides the reader with the most up-to-date developments in this area.
- Contents
- 1. An Overview of Inflammatory Arthritis -- 2. Epidemiology and Pathology -- 3. Clinical Features -- 4. Clinical and Laboratory Assessments -- 5. Symptomatic Drug Treatment -- 6. Disease-Modifying Anti-Rheumatic Drugs -- 7. Biologics: An Overview -- 8. Anti-Tumour Necrosis Factor-Alpha (TNF-) Treatment -- 9. B Cell Inhibition and other Biologics -- 10. Steroids -- 11. Non-Drug Treatments -- 12. Stopping Treatments -- 13. Emerging Therapies in Rheumatoid Arthritis -- 14. Stratified Medicine in Inflammatory Arthritis.
- Format
- e-Book
- Location
- Online
Inflammatory Diseases of the Brain
https://libcat.nshealth.ca/en/permalink/provcat32608
Stefan Hähnel, editor.
(2nd ed.)
--Berlin, Heidelberg:
Springer
, c2013.
- Available Online
- View e-Book
- Location
- Online
Inflammatory diseases of the CNS are playing an increasingly important role in the clinical practice of neuroradiology. Neuroimaging contributes greatly to the differentiation of infectious (e.g., viral encephalitis and pyogenic brain abscess) and noninfectious (e.g., multiple sclerosis) inflammatory brain diseases and to the distinction between brain inflammation and other brain diseases, e.g., neoplastic or ischemic.This second, updated edition of Inflammatory Diseases of the Brain provides a…
- Available Online
- View e-Book
- Author
- Hähnel, Stefan
- Responsibility
- Stefan Hähnel, editor
- Edition
- 2nd ed.
- Place of Publication
- Berlin, Heidelberg
- Publisher
- Springer
- Date of Publication
- c2013
- Physical Description
- 1 online resource (xii, 182 p. : 310 ill., 10 ill. in color)
- Series
- Medical radiology. Diagnostic imaging
- Series Title
- Medical radiology (Series)
- ISBN
- 9783642305207
- Subjects (MeSH)
- Brain Diseases - diagnosis
- Brain Diseases - diagnostic imaging
- Inflammation - diagnosis
- Neuroimaging - methods
- Radiography
- Subjects (LCSH)
- Infectious diseases
- Neurology
- Radiology, Medical
- Abstract
- Inflammatory diseases of the CNS are playing an increasingly important role in the clinical practice of neuroradiology. Neuroimaging contributes greatly to the differentiation of infectious (e.g., viral encephalitis and pyogenic brain abscess) and noninfectious (e.g., multiple sclerosis) inflammatory brain diseases and to the distinction between brain inflammation and other brain diseases, e.g., neoplastic or ischemic.This second, updated edition of Inflammatory Diseases of the Brain provides a comprehensive overview of the field from a neuroradiological point of view. In order to ensure a standardized approach throughout the book, each disease-oriented chapter is again subdivided into three principal sections: epidemiology, clinical presentation, and therapy; imaging; and differential diagnosis. A separate chapter addresses technical and methodological issues and imaging protocols. An important focus of the book is the current role of advanced MR imaging techniques, such as diffusion and perfusion MRI and MR spectroscopy, in the differentiation of inflammatory and other brain diseases.All of the authors are recognized experts, and the numerous high-quality and informative illustrations include some not contained in the first edition. This book will be of great value not only to neuroradiologists but also to neurologists, neuropediatricians, and general radiologists.
- Contents
- Part I: Brain Parenchyma -- Multiple Sclerosis and Other Demyelinating Diseases -- 1. Multiple Sclerosis -- 2. Other Demyelinating Diseases -- Cerebral Vasculitis -- 1. Epidemiology, Clinical Presentation and Therapy -- 2. Cerebral Vasculitis: Imaging and Differential Diagnosis -- Pyogenic Cerebritis and Brain Abscess -- Neurolues -- Neurotuberculosis -- Other Bacterial Infections -- Viral Encephalitis -- Spongiform Encephalopathies -- Fungal Infections -- Parasitic Infections -- Part II: Meninges -- Inflammatory Diseases of the Meninges -- Part III: Specific Topics -- Granulomatous Diseases -- Neuro-Infectious Disorders of Childhood -- MR Imaging and Spectroscopic Specifics and Protocols -- Acronyms -- Index.
- Format
- e-Book
- Location
- Online
Inflammatory diseases of the central nervous system
https://libcat.nshealth.ca/en/permalink/provcat25267
Kilpatrick, Trevor.
--Cambridge, England:
Cambridge University Press
, 2010.
- Call Number
- WL 301 I43 2010
- Location
- Halifax Infirmary
- Call Number
- WL 301 I43 2010
- Author
- Kilpatrick, Trevor
- Other Authors
- Ransohoff, Richard M
- Wesselingh, Steven
- Place of Publication
- Cambridge, England
- Publisher
- Cambridge University Press
- Date of Publication
- 2010
- Physical Description
- 271 p.
- ISBN
- 9780521888745
- Subjects (MeSH)
- Central Nervous System Diseases - immunology
- Central Nervous System Diseases - physiopathology
- Central Nervous System - immunology
- Inflammation
- Neuroimmunomodulation - physiology
- Contents
- [Machine generated contents note] Preface; Part I. Interactions Between the Immune and Nervous Systems: 1. Effectors and determinants of the innate and adaptive immune responses / Edgar Meinl and Hartmut Wekerle; 2. Microglia: protective and pathogenic mediators / Bevyn Jarrott and Karina Apric-; 3. The role of dendritic cells in neuroinflammation / Heather Donaghy, Edwina J. Wright and Anthony L. Cunningham; 4. Negotiating the brain barriers: access of immune cells and pathogens into the CNS / Britta Engelghardt; Part II. Autoimmunity: 5. Immune effector heterogeneity in multiple sclerosis and related CNS inflammatory demyelinating disorders / Shaunu F. Roemer and Claudia F. Lucchinetti; 6. Multiple sclerosis: neuroimmune crosstalk in acute and progressive stages of the disease / Martin Kerschensteiner and Reinhard Hohlfeld; 7. CD8+ T Cell-mediated autoimmune diseases in the CNS / Lisa Walter and Matthew L. Albert; 8. Acute disseminated encephalomyelitis: determinants and manifestations / Eppie M. Yiu and Andrew J. Kornberg; 9. Primary angiitis of the CNS and its mimics / Tina Chadha, George F. Duna and Leonard H. Calabrese; Part III. Microbiological and Traumatic Challenges to the CNS: 10. Acute viral encephalitis: role of the immune system in viral clearance from the CNS and in the generation of pathology / David N. Irani and Natalie Prow; 11. Chronic HIV infection of the CNS: role of the immune system in virological control and the generation of pathology / Carolyn F. Orr and Bruce J. Brew; 12. Brain inflammation during bacterial meningitis / Trine H. Mogensen and Lars Østergaard; 13. Parasitic infections of the brain: malaria and beyond / Stephen J. Rogerson and Danny A. Milner Jr; 14. Role of the inflammatory process in traumatic brain damage / Cristina Morganti-Kossmann, Laveniya Satgunaseelan, Nicole Bye, Phuong Nguyen and Thomas Kossmann; Part IV. Therapy: 15. HIV-associated neurocognitive disorders: clinical features and therapeutic challenges / Nicoline Schiess and Justin C. McArthur; 16. Role of immunomodulation in management of infections of the CNS / Miles H. Beaman; 17. Neuroinflammation: an emerging therapeutic target in neurological disease / Joseph M. Antony and Christopher Power; Index.
- Format
- Book
- Location
- Halifax Infirmary
- Loan Period
- 3 weeks
