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Biomarkers in Inflammatory Bowel Diseases

https://libcat.nshealth.ca/en/permalink/provcat44481
Nik Sheng Ding, Peter De Cruz, editors. --Cham: Springer , c2019.
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Location
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This book provides a comprehensive and complete overview of biomarkers in clinical practice for inflammatory bowel disease (IBD) bringing together the literature in a clear and concise manner. The book bridges the gap between growing knowledge at the bench and current and future applications of biomarkers in clinical practice. The central structure of the book focuses on prognostic and predictive biomarkers in IBD with an emphasis on the fields of research and scientific techniques (genomics, p…
Available Online
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Other Authors
Sheng Ding, Nik
De Cruz, Peter
Responsibility
Nik Sheng Ding, Peter De Cruz, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2019
Physical Description
1 online resource (xvii, 365 p.) : 35 illus., 30 illus. in color
ISBN
9783030114466
9783030114459 (Print ed.)
9783030114473 (Print ed.)
Subjects (MeSH)
Biomarkers
Inflammatory Bowel Diseases - diagnosis
Specialty
Clinical Laboratory Techniques
Gastroenterology
Abstract
This book provides a comprehensive and complete overview of biomarkers in clinical practice for inflammatory bowel disease (IBD) bringing together the literature in a clear and concise manner. The book bridges the gap between growing knowledge at the bench and current and future applications of biomarkers in clinical practice. The central structure of the book focuses on prognostic and predictive biomarkers in IBD with an emphasis on the fields of research and scientific techniques (genomics, proteomics and metabonomics) that have led to biomarker discovery and places these biomarkers within a clinical context to help understand their utility in clinical practice. This book will be of use to clinicians who have an interest in using biomarkers in clinical practice as well as clinician researchers and scientists involved in the biomarker research pipeline. The author team comprises experts from around the world in order to bring together the literature in an effort to inform clinicians and researchers about the current state-of-the art in biomarker discovery. It is intended to assist future research efforts and indicate how biomarkers might be best applied to clinical practice both at present and in the future.
Contents
1. Introduction -- Part I. Background to Biomarkers -- 2. Clinical Risk Factors: Lessons from Epidemiology -- 3. Disease Modification in Crohn’s Disease -- 4. Personalized Medicine - Dream or Reality? -- 5. Clinical Trial Design to Facilitate Biomarker Discovery -- Part II. Clinical Algorithms Incorporating Predictive and Prognostic Biomarkers: Crohn’s Disease -- 6. Luminal Crohn’s Disease -- 7. Fibrosis and Stricturing Disease in Crohn’s Disease -- 8. Postoperative Crohn’s Disease -- 9. Perianal Crohn’s Disease -- Part III. Clinical Algorithms Incorporating Predictive and Prognostic Biomarkers: Ulcerative Colitis -- 10. Biomarkers in Acute Severe Ulcerative Colitis -- 11. Chronic Active Ulcerative Colitis -- 12. Refractory Proctitis -- 13. UC Surveillance -- 14. The Role of Biomarkers in the Ileal Anal Pouch -- Part IV. Clinical Algorithms Incorporating Predictive and Prognostic Biomarkers: Specialised Scenarios -- 15. Extra-intestinal Manifestations in Inflammatory Bowel Disease: Diagnosis and Management -- 16. Primary Sclerosing Cholangitis Overlapping with IBD -- 17. Pregnancy and IBD -- 18. Nutrition in IBD -- 19. Therapeutic Drug Monitoring in Inflammatory Bowel Disease: Optimising Therapeutic Effectiveness of Thiopurines -- 20. Therapeutic Drug Monitoring in Inflammatory Bowel Disease: Optimising Therapeutic Effectiveness of Biologics -- 21. Drug Toxicity: Personalising IBD Therapeutics–The Use of Genetic Biomarkers to Reduce Drug Toxicity -- 22. Biomarkers for Remote Monitoring -- Part V. Scientific Platforms for Biomarker Discovery -- 23. Exposome and Diet -- 24. The Microbiome in IBD -- 25. Metabolic Profiling in IBD -- 26. Innate and Adaptive Immunology -- 27. Genetic and Genomic Markers for Prognostication -- 28. Risk Alleles for Drug Targets: Genomic Markers of Drug Response -- Part VI. Conclusion -- 29. Big Data Meets Real World! The Use of Clinical Informatics in Biomarker Research -- 30. Bringing It Altogether: A Systems Biology Approach to Biomarkers in Inflammatory Bowel Disease.
Format
e-Book
Location
Online
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Silvio Mazziotti, Alfredo Blandino ; in collaboration with Giorgio Ascenti, Tommaso D'Angelo. --Milan: Springer , c2014.
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Location
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In recent years, there has been huge interest in developing new methods that offer improved accuracy for the detection of small bowel pathology, and in particular for the assessment of inflammatory bowel diseases (IBD). Cross-sectional imaging, such as CT and MR, has advantages over traditional barium fluoroscopic techniques in terms of direct visualization of the bowel wall and improved visualization of extraluminal findings and complications. This means a complete change in the diagnostic app…
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Author
Mazziotti, Silvio
Other Authors
Blandino, Alfredo
Ascenti, Giorgio
D'angelo, Tommaso
Responsibility
Silvio Mazziotti, Alfredo Blandino ; in collaboration with Giorgio Ascenti, Tommaso D'Angelo
Alternate Title
Magnetic resonance enterography
Place of Publication
Milan
Publisher
Springer
Date of Publication
c2014
Physical Description
1 online resource (xi, 150 pages)
ISBN
9788847056756 (electronic bk.)
9788847056701
Subjects (MeSH)
Intestinal Diseases - diagnosis
Intestine, Small - pathology
Subjects (LCSH)
Contrast-enhanced magnetic resonance imaging
Inflammatory bowel diseases - Magnetic resonance imaging
Abstract
In recent years, there has been huge interest in developing new methods that offer improved accuracy for the detection of small bowel pathology, and in particular for the assessment of inflammatory bowel diseases (IBD). Cross-sectional imaging, such as CT and MR, has advantages over traditional barium fluoroscopic techniques in terms of direct visualization of the bowel wall and improved visualization of extraluminal findings and complications. This means a complete change in the diagnostic approach to the patient with IBD: from analysis of the bowel surface to direct evaluation of parietal alterations and assessment of peri- and extraintestinal involvement. The ideal imaging test is reproducible, well tolerated by patients and, above all, free of ionizing radiation. MR enterography, currently performed only in a few reference centers, meets these criteria and offers accurate diagnosis, particularly in respect of the wide spectrum of intra- and extraintestinal complications of IBD. This book provides a thorough overview of the indications, techniques, diagnostic advantages, and limitations of MR enterography. Particular attention is paid to patient preparation in relation to the particular study type and to the potential advantages of the most up-to-date MR studies in specific cases, e.g., allergy or renal failure. A separate chapter is devoted to MR of perianal region for the detection and staging of perianal fistula, a common complication in patients with Crohn's disease.
Contents
1. Introduction -- Part I. MR Enterography: Technique and Anatomy -- 2. Technique -- 3. Normal MR Anatomy -- Part II. MR Enterography: Clinical Applications -- 4. MR Findings in Crohn’s Disease -- 5. Extraintestinal Complications -- 6. Perianal Complications -- 7. Other Indications for MRE.
Format
e-Book
Location
Online
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