Clinical lipidology : a companion to Braunwald's heart disease
https://libcat.nshealth.ca/en/permalink/provcat33488
[edited by] Christie M. Ballantyne.
(2nd ed.)
--Philadelphia, PA:
Elsevier Saunders
, c2015.
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- Location
- Online
Clinical Lipidology, a companion to Braunwald’s Heart Disease, is designed to guide you through the ever-changing therapeutic management of patients with high cholesterol levels. From basic science to pathogenesis of atherothrombotic disease, to risk assessment and the latest therapy options, this medical reference book offers unparalleled coverage and expert guidance on lipidology in a straightforward, accessible, and user-friendly style.
- Available Online
- View e-Book
- Other Authors
- Ballantyne, Christie M
- Responsibility
- [edited by] Christie M. Ballantyne
- Edition
- 2nd ed.
- Place of Publication
- Philadelphia, PA
- Publisher
- Elsevier Saunders
- Date of Publication
- c2015
- Physical Description
- 1 online resource, 568 p.
- ISBN
- 9780323324991
- Subjects (MeSH)
- Lipoproteins - metabolism
- Cardiovascular Diseases - complications
- Dyslipidemias
- Lipid Metabolism
- Subjects (LCSH)
- Lipids
- Lipoproteins
- Heart - Diseases
- Lipoproteins - metabolism
- Cardiovascular Diseases - complications
- Dyslipidemias
- Lipid Metabolism
- Notes
- Complemented by: Braunwald's heart disease / edited by Douglas L. Mann, Douglas P. Zipes, Peter Libby, Robert O. Bonow, Eugene Braunwald. 10th edition. [2015]
- Abstract
- Clinical Lipidology, a companion to Braunwald’s Heart Disease, is designed to guide you through the ever-changing therapeutic management of patients with high cholesterol levels. From basic science to pathogenesis of atherothrombotic disease, to risk assessment and the latest therapy options, this medical reference book offers unparalleled coverage and expert guidance on lipidology in a straightforward, accessible, and user-friendly style.
- Contents
- Human plasma lipoprotein metabolism -- Regulation and clearance of apolipoprotein B-containing lipoproteins -- Absorption and excretion of intestinal cholesterol and other sterols -- High-density lipoprotein metabolism -- Lipoproteins : mechanisms for atherogenesis and progression of atherothrombotic disease -- Impact of rare and common genetic variants on lipoprotein metabolism -- Lipoprotein oxidation : mechanisms and biotheranostic applications -- Cholesterol : concentration, ratio, and particle number -- High-density lipoprotein cholesterol and triglycerides in coronary heart disease risk assessment -- Lipoprotein(a) -- Clinical evaluation for genetic and secondary causes of dyslipidemia -- Use of high-sensitivity c-reactive protein for risk assessment -- Role of lipoprotein-associated phospholipase A2 in vascular disease -- Emerging assays -- Imaging atherosclerosis for risk stratification by cardiac computed tomography or carotid ultrasound -- Overview of general approach to management of elevated low-density lipoprotein cholesterol and mixed dyslipidemia, high triglycerides, and low high-density lipoprotein cholesterol -- Treatment guidelines overview -- Dietary patterns for the prevention and treatment of cardiovascular disease -- Exercise and lipids -- Weight loss -- Statins -- Bile acid sequestrants -- Cholesterol absorption inhibitors -- Niacin (nicotinic acid) -- Fibrates -- Omega-3 fatty acids -- Combination therapy for dyslipidemia -- Nutraceuticals and functional foods for cholesterol reduction -- Evolving targets of therapy : cholesteryl ester transfer protein inhibition -- Evolving targets of therapy : proprotein convertase subtilisin/kexin 9 inhibition -- Evolving targets of therapy : inflammation as a method to predict and prevent cardiovascular events -- Invasive imaging modalities and atherosclerosis : intravascular ultrasound -- Noninvasive imaging modalities and atherosclerosis : the role of ultrasound -- Noninvasive imaging modalities and atherosclerosis : the role of magnetic resonance imaging and positron emission tomography imaging -- Special patient populations : diabetes and metabolic syndrome -- Special patient populations : women and elderly -- Special patient populations : children and adolescents -- Special patient populations : familial hypercholesterolemia and other severe hypercholesterolemias -- Special patient populations : acute coronary syndromes -- Special patient populations : transplant recipients -- Special patient populations : chronic kidney disease -- Special patient populations : lipid abnormalities in high-risk ethnic groups -- Special patient populations : human immunodeficiency virus patients -- Therapeutic targeting of high-density lipoprotein metabolism.
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- Registration required for PDF access.
- Format
- e-Book
- Location
- Online
Comprehensive lipid testing and management
https://libcat.nshealth.ca/en/permalink/provcat31048
Lars A. Carlson.
--London:
Springer Healthcare
, c2011.
- Available Online
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- Location
- Online
- Available Online
- View e-Book
- Author
- Carlson, Lars A
- Responsibility
- Lars A. Carlson
- Place of Publication
- London
- Publisher
- Springer Healthcare
- Date of Publication
- c2011
- Physical Description
- 1 online resource (xi, 144 p. : 77 ill. in color)
- ISBN
- 9781908517333
- Subjects (MeSH)
- Atherosclerosis - prevention & control
- Coronary Disease - prevention & control
- Dyslipidemias - therapy
- Lipids - blood
- Subjects (LCSH)
- Cardiology
- Contents
- Part one. Lipid testing -- 1. Atherosclerosis and clinical atherosclerosis -- 2. From cholesterol to lipoproteins and apolipoproteins -- 3. Lipid testing -- 4. Lipid profiles -- 5. Lipid testing and prediction of coronary heart disease -- 6. Lipid risk factors in prediction of coronary heart disease: is any one factor best? -- Part two. Lipid management -- 7. Goals of lipid management -- 8. Cholesterol lowering and prevention of CHD -- 9. Cholesterol goals in current guidelines -- 10. Lipid management in clinical practice -- 11. Drugs for lipid management -- 12. Diabetic dyslipidaemia -- 13. LDL apheresis -- 14. Lipid modifying agents under development.
- Format
- e-Book
- Location
- Online
Lipid Nanoparticles : Production, Characterization and Stability
https://libcat.nshealth.ca/en/permalink/provcat39117
Rohan Shah, Daniel Eldridge, Enzo Palombo, Ian Harding.
--Cham:
Springer
, c2015.
- Available Online
- View e-Book
- Location
- Online
What are lipid nanoparticles? How are they structured? How are they formed? What techniques are best to characterize them? How great is their potential as drug delivery systems? These questions and more are answered in this comprehensive and highly readable work on lipid nanoparticles. This work sets out to provide the reader with a clear and understandable understanding of the current practices in formulation, characterization and drug delivery of lipid nanoparticles. A comprehensive descripti…
- Available Online
- View e-Book
- Author
- Shah, Rohan
- Other Authors
- Eldridge, Daniel
- Palombo, Enzo
- Harding, Ian
- Responsibility
- Rohan Shah, Daniel Eldridge, Enzo Palombo, Ian Harding
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2015
- Physical Description
- 1 online resource (ix, 97 p. : 30 illus., 18 illus. in color)
- ISBN
- 9783319107110
- 9783319107103 (print ed.)
- ISSN
- 1864-8118
- Subjects (MeSH)
- Biomedical Engineering
- Lipids
- Nanoparticles
- Nanotechnology
- Abstract
- What are lipid nanoparticles? How are they structured? How are they formed? What techniques are best to characterize them? How great is their potential as drug delivery systems? These questions and more are answered in this comprehensive and highly readable work on lipid nanoparticles. This work sets out to provide the reader with a clear and understandable understanding of the current practices in formulation, characterization and drug delivery of lipid nanoparticles. A comprehensive description of the current understanding of synthesis, characterization, stability optimization and drug incorporation of solid lipid nanoparticles is provided. Nanoparticles have attracted great interest over the past few decades with almost exponential growth in their research and application. Their small particle size and subsequent high surface area make them ideal in many uses, but particularly as drug carrier systems. Nanoparticles made from lipids are especially attractive because of their enhanced biocompatibility imparted by the lipid. The work provides a detailed description of the types of lipid nanoparticles available (e.g. SLN, NLC, LDC, PLN) and how they range from imperfect crystalline to amorphous in structure. Current thoughts on where drugs are situated (e.g. in the core, or at the interface) and how this can be manipulated are discussed. The many techniques for production, including the author's own variant of microwave heating, are fully discussed. Techniques for measuring arguably the most important characteristics of particle size and polydispersity are discussed, along with techniques to measure crystallinity, shape and drug capacity. Finally, a full chapter on techniques for measuring stability, both in the absence and presence of drugs, is discussed, along with suggestions on how to optimize that stability. This work appeals to students of colloid science, practitioners of research into drug delivery and academics alike.
- Contents
- Introduction -- Composition and structure -- Production techniques -- Characterization -- Physicochemical stability.
- Format
- e-Book
- Location
- Online
Manual of lipid disorders
https://libcat.nshealth.ca/en/permalink/provcat21131
Gotto, Antonio M.
(3rd ed.)
--Philadelphia, PA:
Lippincott Williams & Wilkins
, 2003.
- Call Number
- QU 85 G881m 2003
- Location
- Dickson Building
- Call Number
- QU 85 G881m 2003
- Author
- Gotto, Antonio M.
- Other Authors
- Pownall, Henry J
- Edition
- 3rd ed.
- Place of Publication
- Philadelphia, PA
- Publisher
- Lippincott Williams & Wilkins
- Date of Publication
- 2003
- Physical Description
- 482 p.
- ISBN
- 078173584X
- Subjects (MeSH)
- Lipids
- Format
- Book
- Location
- Dickson Building
- Loan Period
- 3 weeks
Physiology and physiopathology of adipose tissue
https://libcat.nshealth.ca/en/permalink/provcat32475
Jean-Philippe Bastard, Bruno Fève, editors.
--Paris:
Springer
, c2013.
- Available Online
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- Location
- Online
The scientific advances in the physiology and pathophysiology of adipose tissue over the last two decades have been considerable. Today, the cellular and molecular mechanisms of adipogenesis are well known. In addition, adipose tissue is now recognized as a real endocrine organ that produces hormones such as the leptin acting to regulate food intake and energy balance in the central nervous system, a finding that has completely revolutionized the paradigm of energy homeostasis. Other adipokines…
- Available Online
- View e-Book
- Other Authors
- Bastard, Jean-Philippe
- Fève, Bruno
- Responsibility
- Jean-Philippe Bastard, Bruno Fève, editors
- Place of Publication
- Paris
- Publisher
- Springer
- Date of Publication
- c2013
- Physical Description
- 1 online resource (xix, 437 p. : 51 ill. in color)
- ISBN
- 9782817803432
- Subjects (MeSH)
- Adipose Tissue - physiology
- Adipose Tissue - physiopathology
- Obesity - physiopathology
- Subjects (LCSH)
- Endocrinology
- Metabolic diseases
- Lipids
- Abstract
- The scientific advances in the physiology and pathophysiology of adipose tissue over the last two decades have been considerable. Today, the cellular and molecular mechanisms of adipogenesis are well known. In addition, adipose tissue is now recognized as a real endocrine organ that produces hormones such as the leptin acting to regulate food intake and energy balance in the central nervous system, a finding that has completely revolutionized the paradigm of energy homeostasis. Other adipokines have now been described and these molecules are taking on increasing importance in physiology and pathophysiology. Moreover, numerous works have shown that in obesity, but also in cases of lipodystophy, adipose tissue was the site of a local low-grade inflammation that involves immune cells such as macrophages and certain populations of lymphocytes. This new information is an important step in the pathophysiology of both obesity and related metabolic and cardiovascular complications. Finally, it is a unique and original work focusing on adipose tissue, covering biology and pathology by investigating aspects of molecular and cellular biology, general, metabolic, genetic and genomic biochemistry.
- Contents
- Foreword -- Part I: Adipose tissue development -- 1. Development of adipose cells -- 2. Emerging roles of cell cycle regulators in adipocyte metabolism -- 3. Angiogenesis in adipose tissue -- 4. Prospects for using adipose tissue in regenerative medicine -- 5. Brown adipose tissue: function and development -- 6. Histology of adipose tissue -- Part II: Adipose tissue metabolic functions -- 7. Glucose transport in white adipocyte -- 8. Mechanism of storage and synthesis of fatty acids and triglycerides in white adipocytes -- 9. Adipocyte lipid droplet physiology -- 10. Adipose tissue lipolysis -- 11. The adipose tissue: storage, source and target of pollutants -- Part III: Endocrine functions of adipocyte -- 12. Chatting between the brain and white adipose tissues -- 13. Adiponectin: an adipokine with multiple faces -- 14. Apelin metabolic functions -- 15. Up-to-date on novel "adipocrines" -- Part IV: Pathology of adipose tissue -- 16. Obesity: an evolving process -- 17. Obesity phenotypes : Measures to assess adipose tissue mass in humans -- 18. Animal models of obesity -- 19. Contribution of "omics" approaches to understand the pathophysiology of obesity -- 20. Adipose tissue inflammation in obesity -- 21. Impact of proinflammatory cytokines on adipocyte insulin signaling -- 22. Adaptive changes in human adipose tissue during weight gain -- 23. Differences between subcutaneous and visceral adipose tissues -- 24. Genetics of human obesities -- 25. Genetic and acquired lipodystrophic syndromes -- 26. Is adipose tissue a relevant therapeutic target of obesity? -- Index.
- Format
- e-Book
- Location
- Online
