Skip header and navigation
Did you mean topic:"medical laboratorial"? Also try laboratorial.

Narrow By

25 records – page 1 of 2.

Basic Science Techniques in Clinical Practice

https://libcat.nshealth.ca/en/permalink/provcat30038
edited by H. R. H. Patel, M. Arya, I. S. Shergill. --London: Springer-Verlag , c2007.
Available Online
View e-Book
Location
Online
Available Online
View e-Book
Author
Patel, H.R.H
Other Authors
Arya, M
Shergill, I.S
Responsibility
edited by H. R. H. Patel, M. Arya, I. S. Shergill
Place of Publication
London
Publisher
Springer-Verlag
Date of Publication
c2007
ISBN
9781846287404
Subjects (MeSH)
Biomedical Research - methods
Clinical Laboratory Techniques
Subjects (LCSH)
Medical laboratories
Format
e-Book
Location
Online
Less detail

Biotargets of Cancer in Current Clinical Practice

https://libcat.nshealth.ca/en/permalink/provcat31016
Mauro Bologna, editor. --New York, NY: Humana Press , c2012.
Available Online
View e-Book
Location
Online
Biotargets of Cancer in Current Clinical Practice presents an updated and reasoned review of the current status of knowledge concerning the major cancer types with a special focus on the current biomarkers, genes involved and the potential future targets of innovative therapies. The volume includes for each major cancer type, a comprehensive although concise discussion of epidemiology, affirmed and innovative biomarkers for diagnosis, and descriptions of the relevant genes for prognosis and (in…
Available Online
View e-Book
Other Authors
Bologna, Mauro
Responsibility
Mauro Bologna, editor
Place of Publication
New York, NY
Publisher
Humana Press
Date of Publication
c2012
Physical Description
1 online resource (xvi, 563 p. : 100 ill., 57 ill. in color)
Series Title
Current clinical pathology
ISBN
9781617796159
Subjects (MeSH)
Biological Markers
Molecular Targeted Therapy
Neoplasms - therapy
Subjects (LCSH)
Medical laboratories
Oncology
Pathology
Abstract
Biotargets of Cancer in Current Clinical Practice presents an updated and reasoned review of the current status of knowledge concerning the major cancer types with a special focus on the current biomarkers, genes involved and the potential future targets of innovative therapies. The volume includes for each major cancer type, a comprehensive although concise discussion of epidemiology, affirmed and innovative biomarkers for diagnosis, and descriptions of the relevant genes for prognosis and (individualized) therapy through biotarget-specific new molecular treatments, with the latest information on the validation status of each novel biomarker. Individual chapters are dedicated to the major cancer types, plus a special chapter on metastasis. The present debate on patentability of genetic information applied to diagnostics and therapeutics of cancer is also discussed.
Contents
Central Nervous System Tumors -- Head and Neck Tumors -- Thyroid Cancer -- Targeted Therapies for Non-Small Cell Lung Cancer -- Non-Hodgkin Lymphomas -- Leukemias -- Breast Cancer -- Esophago-Gastric Cancer -- Colorectal Cancer -- Hepatocellular Carcinoma -- Biomarkers for Prognosis and Molecularly Targeted Therapy in Renal Cell Carcinoma -- Bladder Cancer -- Biomarkers in Prostate cancer -- Ovarian Cancer -- Uterine Cancer: The Influence of Genetics and Environment on Cell Cycling Pathways in Cancer -- Biotargets in Sarcomas: The Past, Present and a Look into the Future -- Melanoma and other skin cancers -- Molecular pathology of cancer metastasis: suggestions for future therapy -- Current and future developments in cancer therapy research: miRNAs as new promising targets or tools.
Format
e-Book
Location
Online
Less detail

Clinical Research Informatics

https://libcat.nshealth.ca/en/permalink/provcat31039
Rachel L. Richesson, James E. Andrews, editors. --London: Springer , c2012.
Available Online
View e-Book
Location
Online
Clinical research informatics (CRI) is the application of informatics principles and techniques to support the spectrum of activities and business processes that instantiate clinical research. Informatics, defined generally as the intersection of information and computer science with a health-related discipline, has a foundation drawn from many well-established, theory-based disciplines, including computer science, library and information science, cognitive science, psychology, and sociology. T…
Available Online
View e-Book
Other Authors
Richesson, Rachel L
Andrews, James E
Responsibility
Rachel L. Richesson, James E. Andrews, editors
Place of Publication
London
Publisher
Springer
Date of Publication
c2012
Physical Description
1 online resource (ix, 419 p. : 29 ill., 15 ill. in color)
Series Title
Health informatics
ISBN
9781848824485
Subjects (MeSH)
Biomedical Research - methods
Informatics
Subjects (LCSH)
Medical laboratories
Medical records - Data processing
Abstract
Clinical research informatics (CRI) is the application of informatics principles and techniques to support the spectrum of activities and business processes that instantiate clinical research. Informatics, defined generally as the intersection of information and computer science with a health-related discipline, has a foundation drawn from many well-established, theory-based disciplines, including computer science, library and information science, cognitive science, psychology, and sociology. The newly articulated yet fundamental theorem of informatics states that information technology should be used to enable humans to function and perform better together than humans alone, and so informatics is a source for supportive technologies and tools that enhance--but not replace--unreservedly human processes. Clinical Research Informatics contributes to the ongoing dialogues among researchers and practitioners in CRI as they continue to rise to the challenges of a dynamic and evolving clinical research environment. The development of CRI as a sub-discipline of informatics, and as an independent/maturing professional practice area in its own right, drives a growing pool of scientific literature based on original CRI research, and high-impact tools and systems will be developed. CRI leaders and stakeholder groups will continue to support and create communities of discourse that will address much needed practice standards in CRI, improved safety and efficiencies in clinical research, data standards in clinical research, policy issues, educational standards and instructional resources. The Editors and contributors to this book are among the most active and engaged in the CRI domain and provide an excellent primer for deeper explorations into this emerging discipline. Certain themes are highlighted, including the changing role of the consumer, movement toward transparency, growing needs for global coordination and cooperation on many levels, and the merging together of clinical care delivery and research as part of a changing paradigm in global healthcare delivery--all in the context of rapid innovations in technology and explosions of data sources, types, and volume. This book is therefore of considerable interest to all students of biomedical informatics, from the newcomer to the professional informatician.
Contents
Section I: Contexts of Clinical Research Informatics -- Introduction to Clinical Research Informatics -- From Notations to Data: The Digital Transformation of Clinical Research -- Clinical Research Environment. - Statistical and Study Design Foundations of Clinical Research -- Informatics Approaches to Participant Recruitment -- The Evolving Role of Consumers -- Clinical Research in the Post-Genomic Era -- Section II: Data Management and Systems in Clinical Research -- Clinical Research Information Systems -- Study Protocol Representation -- Data Quality in Clinical Research -- Patient-Reported Outcome Data -- Biobanking Challenges and Informatics Opportunities -- Patient Registries -- Section III: Knowledge Representation and Discovery -- Knowledge Representation and Ontologies -- Non-hypothesis Driven Research: Data Mining and Knowledge Discovery -- Natural Language Processing, Electronic Health Records, and Clinical Research -- Section IV: The Future of Clinical Research, Health, and Clinical Research Informatics -- Data Sharing: Electronic Health Records and Research Interoperability -- Standards Development and the Future of Research Data Sources, Interoperability, and Exchange -- Pharmacovigilance -- Clinical Trials Registries and Results Databases -- Future Directions in Clinical Research Informatics -- Index.
Format
e-Book
Location
Online
Less detail

Cytopreparation : principles & practice

https://libcat.nshealth.ca/en/permalink/provcat32409
Gary W. Gill, author. --New York, NY: Springer , c2013.
Available Online
View e-Book
Location
Online
Cytopreparation: Principles & Practice by Gary W. Gill fills a long-standing need for an easy-to-use and authoritative manual on the fundamentals of cytopreparation up-to-and- including microscopy, screening, and data analysis. The text describes in phenomenological terms the most common materials and methods of specimen collection through mounting for gyn, non-gyn, and FNA specimens, as well as the underlying mechanistic bases. The author provides his expertise and information that will empowe…
Available Online
View e-Book
Author
Gill, Gary W
Responsibility
Gary W. Gill, author
Place of Publication
New York, NY
Publisher
Springer
Date of Publication
c2013
Physical Description
1 online resource (xxx, 437 p. : 131 ill., 106 ill. in color)
Series
Essentials in cytopathology
Series Vol.
v. 12
Series Title
Essentials in cytopathology series
ISBN
9781461449331
Subjects (MeSH)
Cytological Techniques - methods
Subjects (LCSH)
Medical laboratories
Pathology
Microscopy
Abstract
Cytopreparation: Principles & Practice by Gary W. Gill fills a long-standing need for an easy-to-use and authoritative manual on the fundamentals of cytopreparation up-to-and- including microscopy, screening, and data analysis. The text describes in phenomenological terms the most common materials and methods of specimen collection through mounting for gyn, non-gyn, and FNA specimens, as well as the underlying mechanistic bases. The author provides his expertise and information that will empower and enable readers to review and improve their laboratories' cytopreparatory techniques as they apply to the vast majority of specimens. This unique volume provides facts that are not readily available anywhere. Cytopreparation: Principles & Practice is intended for everyone associated with, and involved in, making cytologic preparations that are useful for their intended purpose. It will serve as a valuable reference tool for educators in cytology and histology, cytotechnology and histotechnology students, cytotechnologists, cytopreparatory technicians, cytopathologists, anatomical/clinical pathologists, pathology residents and cytopathology fellows.
Contents
Introduction -- Quality Control and Quality Assessment -- Specimen Collection -- Salt Solutions -- Slide Preparation -- Cytocentrifugation -- Membrane Filtration -- Fixation -- Cell Block Preparation -- Papanicolaou Stain -- Cross-contamination Control -- H&E Stain -- Romanowsky Stains -- Special Stains -- Clearing -- Mounting Media -- Cover Glasses -- Mounting -- Kœhler Illumination -- Screening -- Bethesda System 2001, CLIA '88, and Data Analysis -- APPENDIX -- Index.
Format
e-Book
Location
Online
Less detail

Dawn and evolution of cardiac procedures : research avenues in cardiac surgery and interventional cardiology

https://libcat.nshealth.ca/en/permalink/provcat32524
Marco Picichè, editor ; foreword by Alain Carpentier. --Milan: Springer , c2013.
Available Online
View e-Book
Location
Online
The origins of cardiac surgery are dramatic. It has evolved through the efforts of visionaries who were often criticized and at times dismissed as mad, as well as the great number of desperate patients who accepted to subject themselves to new and untried procedures in the hope of cheating death. While often disregarded, the history of scientific inquiry has much to teach us, and that of cardiac surgery and interventional cardiology is no exception. To discuss the dawn and evolution of cardiac …
Available Online
View e-Book
Other Authors
Picichè , Marco
Responsibility
Marco Picichè, editor ; foreword by Alain Carpentier
Place of Publication
Milan
Publisher
Springer
Date of Publication
c2013
Physical Description
1 online resource (xxii, 353 p. : 90 ill., 45 ill. in color)
ISBN
9788847024007
Subjects (MeSH)
Cardiac Surgical Procedures - history
Cardiac Surgical Procedures - methods
Diagnostic Imaging - History
Subjects (LCSH)
Medical laboratories
Anesthesiology
Cardiology
Heart - Surgery
Biomedical engineering
Abstract
The origins of cardiac surgery are dramatic. It has evolved through the efforts of visionaries who were often criticized and at times dismissed as mad, as well as the great number of desperate patients who accepted to subject themselves to new and untried procedures in the hope of cheating death. While often disregarded, the history of scientific inquiry has much to teach us, and that of cardiac surgery and interventional cardiology is no exception. To discuss the dawn and evolution of cardiac procedures, an international team of cardiac surgeons, interventional cardiologists, anesthesiologists, perfusionists, and biomedical engineers from 22 centers and six countries have been brought together. Each chapter of this book offers a detailed overview of previous investigative efforts and an understanding of the thinking and mentality behind them. Nevertheless, chapters on the recent history of mini-invasive and sutureless valve surgery have also been included, to further assist the reader in transitioning from past to present and on into the future. The attention devoted to research aspects, the comprehensiveness of the historical overview, and the pedagogic and anecdotal nature of the contents make this text unique in the cardiac field and of utmost interest to researchers, cardiac surgeons, cardiologists, residents, medical historians, and biomedical engineers.
Contents
PART I. Research on Cardiac Surgery and Right Cardiac Catheterization before the Advent of Cardiopulmonary Bypass -- PART II. Research on the Cardiopulmonary Bypass Machine -- PART III. Research on Interventional Cardiology and Cardiac Surgery after the Advent of Cardiopulmonary Bypass.
Format
e-Book
Location
Online
Less detail

Diagnostic, Prognostic and Therapeutic Value of Gene Signatures

https://libcat.nshealth.ca/en/permalink/provcat31007
Antonio Russo, Stefano Iacobelli, Juan Iovanna, editors. --New York, NY: Humana Press , c2012.
Available Online
View e-Book
Location
Online
Gene expression studies have revealed diagnostic profiles and upregulation of specific pathways in many solid tumors. The explosion of new information in gene expression profiling could potentially lead to the development of tailored treatments in many solid tumors. In addition many studies are ongoing to validate these signatures also in predicting response to hormonal, chemotherapeutic and targeted agents in breast cancer as well as in other tumors. Diagnostic, Prognostic and Therapeutic Val…
Available Online
View e-Book
Other Authors
Russo, Antonio
Iacobelli, Stefano
Iovanna, Juan
Responsibility
Antonio Russo, Stefano Iacobelli, Juan Iovanna, editors
Place of Publication
New York, NY
Publisher
Humana Press
Date of Publication
c2012
Physical Description
1 online resource (xi, 182 p. : 28 ill., 24 ill. in color)
Series Title
Current clinical pathology
ISBN
9781617793585
Subjects (MeSH)
Gene expression profiling
Genes, neoplasm - genetics
Subjects (LCSH)
Medical laboratories
Genetics
Oncology
Abstract
Gene expression studies have revealed diagnostic profiles and upregulation of specific pathways in many solid tumors. The explosion of new information in gene expression profiling could potentially lead to the development of tailored treatments in many solid tumors. In addition many studies are ongoing to validate these signatures also in predicting response to hormonal, chemotherapeutic and targeted agents in breast cancer as well as in other tumors. Diagnostic, Prognostic and Therapeutic Value of Gene Signatures provides readers a useful and comprehensive resource about the range of applications of microarray technology in oncological diseases. Topics covered include gene signatures and soft tissue sarcomas, prognostic relevance of breast cancer signatures, gene expression profiling of colorectal cancer and liver metastasis, gene signatures in GISTs, CNVs and gene expression profiles in pancreatic cancer, and gene signatures in head/neck, lung and gastric tumors. Diagnostic, Prognostic and Therapeutic Value of Gene Signatures will be of great value to residents and fellows, physicians, pathologists andá medical oncologists.
Contents
Preface -- Gene signatures and soft tissue sarcomas: status of art and perspectives -- Heterogeneity of breast cancer: gene signatures and beyond -- Gene signatures in CRC and liver metastasis -- Gene signatures in gastrointestinal stomal tumors (GIST) -- Pancreatic cancer genetics -- Diagnostic, prognostic and therapeutic value of gene signatures in non-small-cell lung cancer -- Gene signatures in gastric cancer -- Gene signatures in colorectal cancer -- The role of epigenetics in cancer: from molecular function to high-throughput assays -- Primary epithelial ovarian neoplasms: new concepts concerning origin, pathogenesis and classification based on morphology, immunomarkers, molecular features and gene expression studies -- Thyroid carcinoma: molecular signature by histotype specific mutations and gene expression patterns.
Format
e-Book
Location
Online
Less detail

ESR Spectroscopy in Membrane Biophysics

https://libcat.nshealth.ca/en/permalink/provcat29138
by Marcus A. Hemminga, Lawrence J. Berliner. --Boston, MA: Springer Science+Business Media , c2007.
Available Online
View e-Book
Location
Online
Available Online
View e-Book
Author
Hemminga, Marcus A
Other Authors
Berliner, Lawrence J
Responsibility
by Marcus A. Hemminga, Lawrence J. Berliner
Place of Publication
Boston, MA
Publisher
Springer Science+Business Media
Date of Publication
c2007
Series Vol.
27
Series Title
Biological Magnetic Resonance
ISBN
9780387493671
Subjects (MeSH)
Electron Spin Resonance Spectroscopy - methods
Membrane Proteins
Subjects (LCSH)
Biochemistry
Medical laboratories
Format
e-Book
Location
Online
Less detail

Evidence Based Pathology and Laboratory Medicine

https://libcat.nshealth.ca/en/permalink/provcat30105
edited by Alberto M. Marchevsky, Mark Wick. --New York, NY: Springer Science+Business Media , c2011.
Available Online
View e-Book
Location
Online
Available Online
View e-Book
Author
Marchevsky, Alberto M
Other Authors
Wick, Mark
Responsibility
edited by Alberto M. Marchevsky, Mark Wick
Place of Publication
New York, NY
Publisher
Springer Science+Business Media
Date of Publication
c2011
ISBN
9781441910301
Subjects (MeSH)
Pathology
Clinical Laboratory Techniques
Evidence-Based Practice
Subjects (LCSH)
Medical laboratories
Pathology
Format
e-Book
Location
Online
Less detail

Flow Cytometry in Hematopathology : A Visual Approach to Data Analysis and Interpretation

https://libcat.nshealth.ca/en/permalink/provcat30088
by Doyen Nguyen, Lawrence W. Diamond, Raul C. Braylan. (2nd ed.) --Totowa, NJ: Humana Press , c2007.
Available Online
View e-Book
Location
Online
Available Online
View e-Book
Author
Nguyen, Doyen
Other Authors
Diamond, Lawrence W
Braylan, Raul C
Responsibility
by Doyen Nguyen, Lawrence W. Diamond, Raul C. Braylan
Edition
2nd ed.
Place of Publication
Totowa, NJ
Publisher
Humana Press
Date of Publication
c2007
ISBN
9781597451628
Subjects (MeSH)
Flow Cytometry - methods
Hematopoietic Stem Cells - pathology
Subjects (LCSH)
Medical laboratories
Hematology
Pathology
Cytology
Format
e-Book
Location
Online
Less detail

The Forensic Laboratory Handbook : Procedures and Practice

https://libcat.nshealth.ca/en/permalink/provcat29333
edited by Ashraf Mozayani, Carla Noziglia. --Totowa, NJ: Humana Press , c2006.
Available Online
View e-Book
Location
Online
Available Online
View e-Book
Author
Mozayani, Ashraf
Other Authors
Noziglia, Carla
Responsibility
edited by Ashraf Mozayani, Carla Noziglia
Place of Publication
Totowa, NJ
Publisher
Humana Press
Date of Publication
c2006
Series Title
Forensic science and medicine
ISBN
9781592599462
Subjects (MeSH)
Forensic Sciences - methods
Clinical Laboratory Techniques
Subjects (LCSH)
Forensic Medicine
Medical laboratories
Format
e-Book
Location
Online
Less detail

Guidelines for Molecular Analysis in Archive Tissues

https://libcat.nshealth.ca/en/permalink/provcat30136
edited by Giorgio Stanta. --Berlin, Heidelberg: Springer-Verlag , c2011.
Available Online
View e-Book
Location
Online
Available Online
View e-Book
Author
Stanta, Giorgio
Responsibility
edited by Giorgio Stanta
Place of Publication
Berlin, Heidelberg
Publisher
Springer-Verlag
Date of Publication
c2011
ISBN
9783642178900
Subjects (MeSH)
Molecular Diagnostic Techniques
Sequence Analysis
Tissue Extracts
Tissue Fixation
Subjects (LCSH)
Medical laboratories
Pathology
Format
e-Book
Location
Online
Less detail

Hematologic Cancers : From Molecular Pathobiology to Targeted Therapeutics

https://libcat.nshealth.ca/en/permalink/provcat31285
Jianguo Tao, Eduardo Sotomayor, editors. --Dordrecht: Springer , c2012.
Available Online
View e-Book
Location
Online
In the last decade, there has been a remarkable explosion of knowledge in hematologic cancer from basic molecular biology and pathology to clinical therapy. This has led to many new advance and insights in the understanding of pathobiology of malignant hematology. New knowledge of disease molecular pathology, cytogenetic, epigenetic and genomic alterations have provided new strategies to attack and eradicate tumor cells at molecular level and significantly impacted our current therapeutics for …
Available Online
View e-Book
Other Authors
Tao, Jianguo
Sotomayor, Eduardo
Responsibility
Jianguo Tao, Eduardo Sotomayor, editors
Place of Publication
Dordrecht
Publisher
Springer
Date of Publication
c2012
Physical Description
1 online resource (vi, 426 p. : 26 ill., 20 ill. in color)
Series Vol.
v. 14
Series Title
Cancer growth and progression
ISBN
9789400750289
Subjects (MeSH)
Hematologic Neoplasms
Subjects (LCSH)
Oncology
Medical laboratories
Hematology
Abstract
In the last decade, there has been a remarkable explosion of knowledge in hematologic cancer from basic molecular biology and pathology to clinical therapy. This has led to many new advance and insights in the understanding of pathobiology of malignant hematology. New knowledge of disease molecular pathology, cytogenetic, epigenetic and genomic alterations have provided new strategies to attack and eradicate tumor cells at molecular level and significantly impacted our current therapeutics for hematological malignancies. The recent and ongoing rapid expansion of knowledge in this area has become extensive, dynamic and diffuse over the literature and research publications. This has led to the need to capture and compile the new and current information about hematologic cancer with special emphasis on translation from molecular pathobiology to targeted therapeutics. In this book experts from around the world share their thoughts and knowledge about the pathobiology of hematologic cancer, as well as their view on current treatment approaches and future development in these malignant hematologic diseases. This book is well suited for hematology residents, fellows and hematology-oncology physicians, hematopathologist as well as basic research scientist in the area of hematologic malignancies.
Contents
[Machine generated contents note] B Cell Growth, Differentiation and Malignancies / Chih-Chi Andrew Hu -- Follicular Lymphoma: Recent Advances / Wing C. Chan -- Chronic Lymphocytic Leukemia: From Pathobiology to Targeted Therapy / Chih-Chi Andrew Hu -- Genetic and Environmental Determinants in Multiple Myeloma: Implications for Therapy / William S. Dalton -- EBV-Positive Diffuse Large B-Cell Lymphoma of the Elderly / Jorge J. Castillo -- HIV and Lymphoma / Brady E. Betran -- Molecular Biology of Mantle Cell Lymphoma / Eduardo M. Sotomayor -- Pathogenesis of Non-Hodgkin Lymphoma Derived from Inflammatory, Autoimmune or Immunologic Disorders / Jianguo Tao -- Pathogenesis of Non-Hodgkin Lymphoma Derived from Infection Diseases / Roger Klein -- Hodgkin Lymphoma: From Molecular Pathogenesis to Targeted Therapy / Anas Younes -- Myelodysplastic Syndromes / Adam Bagg -- Chronic Myeloproliferative Disorders: From Molecular Pathogenesis to Targeted Therapy / Josef Prchal -- Chronic Myeloid Leukemia / Warren Fiskus -- Novel Targeted Therapeutics for Acute Myeloid Leukemia / Jeffrey Lancet -- Novel Targeted Therapeutics for Peripheral T-Cell Lymphoma / Jasmine Zain -- Large Granular Lymphocyte Leukemia – From Molecular Pathogenesis to Targeted Therapy / Thomas P. Loughran Jr. -- Epigenetic Regulation and Therapy in Lymphoid Malignancies / Haifeng Zhao.
Format
e-Book
Location
Online
Less detail

Herbal Drugs and Fingerprints : Evidence Based Herbal Drugs

https://libcat.nshealth.ca/en/permalink/provcat31211
Devi Datt Joshi. --New Delhi: Springer , c2012.
Available Online
View e-Book
Location
Online
Evidence based herbal drugs are on high-acceptance day by day due to health friendly nature compared to synthetic drugs. The active ingredients in herbal drugs are different chemical classes, e.g. alkaloids, coumarins, flavonoids, glycosides, phenols, steroids, terpenes etc., are identified at molecular level using current analytical practices, which are unique characteristic, as finger, so known as fingerprints. The fingerprints are used for assessment of quality consistency and stability by v…
Available Online
View e-Book
Author
Joshi, Devi Datt
Responsibility
Devi Datt Joshi
Place of Publication
New Delhi
Publisher
Springer
Date of Publication
c2012
Physical Description
1 online resource (xvi, 252 p. : 108 ill., 42 ill. in color)
ISBN
9788132208044
Subjects (MeSH)
Chemistry Techniques, Analytical - methods
Plant Preparations - analysis
Plant Preparations - pharmacology
Subjects (LCSH)
Chemistry
Pharmacy
Medical laboratories
Abstract
Evidence based herbal drugs are on high-acceptance day by day due to health friendly nature compared to synthetic drugs. The active ingredients in herbal drugs are different chemical classes, e.g. alkaloids, coumarins, flavonoids, glycosides, phenols, steroids, terpenes etc., are identified at molecular level using current analytical practices, which are unique characteristic, as finger, so known as fingerprints. The fingerprints are used for assessment of quality consistency and stability by visible observation and comparison of the standardized fingerprint pattern, have scientific potential to decipher the claims made on these drugs for authenticity and reliability of chemical constituents, with total traceability, which starts from the proper identification, season and area of collection, storage, their processing, stability during processing, and rationalizing the combinational in case of polyherbal drugs. These quality oriented documents have ample scientific logics so well accepted globally by regulatory authorities and industries, to determine intentional/ unintentional contamination, adulteration, pollutants, stability, quality, etc. parameters. Based on geo-climatic factors, a same plant species has different pharmacological properties due to different ingredients; such regional and morphological variations are identified by fingerprints, at the time of collection of the medicinal herb. The chromatographic (TLC, HPTLC, HPLC, GC,) and spectral (UV-Vis., FTIR, MNR, MS, LC-MS, GC-MS etc.) techniques have world-wide strong scientific approval as validated methods to generate the fingerprints of different chemical classes of active ingredients of herbal drugs. Presently there is a need for a book having all the fingerprinting techniques for herbal drugs at a place with theory, case studies and art to discover patentable forms. The present book is a milestone in the subject, to be utilized by Scientists, Medical Doctors, Technicians, Industrialists, Researchers, and Students both in PG and UG levels.
Contents
[Machine generated contents note] Pt. I. Herbal Drugs: A Review on Practices -- 1. Herbal Drugs: A Review on Practices -- Introduction -- Asian Continent and Traditional Herbal Drugs -- China and Japan -- Indian Subcontinent -- Traditional Herbal Drugs in Europe -- Traditional Herbal Drugs in America -- Traditional Herbal Drugs in Australia -- Traditional Herbal Drugs in Africa -- Industrialization of Herbal Drugs and Legislation -- Phytochemical Standardization -- Extraction of Therapeutics -- Analysis for Marker and Chromatographic Fingerprint -- Preparative HPLC to Isolate Therapeutic -- Biochemical Approach -- Reverse Pharmacology -- New Drug Development -- Synthetic Drug Development -- Modern Approach for Drug Development -- Fingerprints of Drugs: Needs and Values -- Multidisciplinary Strategy to Develop Fingerprints -- Modern Chemistry and Pharmacology -- Standardization of Fingerprints -- Pharmacokinetics of Standardized Form -- Case Study -- Commercial Manufacturing and Quality Control -- Regulatory Norms for Herbal Drugs -- Therapeutic Goods Act -- Drug Administration Law -- Ayush -- Ministry of Health and Welfare, Japan -- Ministry of Health, Saudi Arabia -- WHO Guidelines for Assessment of Herbal Drugs -- References -- Bibliography -- Pt. II. Herbal Drugs and Chromatographic Fingerprints -- 2. TLC: Herbal Drugs and Fingerprints -- Thin-Layer Chromatogram -- Preparation of TLC Plate in Laboratory -- Ready-Made TLC Plate -- Selection of Suitable Plate Size -- Spotting -- Preparation of Developing Chamber -- Chromoplate Generation -- Evaluation of TLC Plate -- Retention Factor -- Presentation of TLC Results -- Procedure to Determine R1 Value of Unknown -- Spot Development by Iodine Vapors -- Documentation of Fingerprints -- Two-Dimensional TLC -- TLC Bioautography -- Bioluminescence and TLC Analysis -- Detection of Colorless Compounds -- Combination of TLC with Other Techniques -- Criteria for Selectivity, Reproducibility and Robustness -- Special Hazards -- Troubleshooting in TLC Analysis -- Identification of Marker Compounds in Herbal Drugs -- TLC Analysis for Alkaloids -- TLC Analysis for Phenols -- TLC Analysis for Saponins -- TLC Analysis for Terpenoids -- TLC with DART-MS -- TLC Fingerprints for Batch to Batch Consistency -- References -- Bibliography -- 3. HPTLC: Herbal Drugs and Fingerprints -- Operational Summary of HPTLC -- HPTLC Pre-Coated Plates -- Detection and Visualization -- Nondestructive Techniques -- Nonreversible Reactions -- Destructive Techniques -- Common Visualizing Reagents -- Group-Specific Reaction -- Coupling of HPTLC with Spectrometry -- References -- Bibliography -- 4. HPLC: Herbal Drugs and Fingerprints -- Glance on HPLC Column -- Analytical Mobile Phases and HPLC -- Solvent Changeover in HPLC -- Buffers as Mobile Phase -- Selection of Buffer and Analytical Method Development -- Buffer Concentration -- Buffer Solubility -- Buffer and Its Impact on Detection -- Buffers as Mobile Phase in HPLC -- Detectors in HPLC: Detection, Quantification, and Fingerprints -- HPLC-UV -- HPLC-FD -- HPLC-CL -- HPLC-ECD -- HPLC Detection in Hyphenated System -- HPLC-RID -- HPLC-ELSD -- HPLC-CAD -- HPLC-FID -- HPLC-MS -- HPLC-NMR -- LC-Hyphenation for Online Structural Identification -- HPLC-DAD (Diode-Array Detector) -- HPLC-MS, MS-MS, and MSn -- HPLC-NMR (Nuclear Magnetic Resonance) -- HPLC Biochemical Detection -- HPTLC-HPLC for Quality Assurance -- Case Study -- Different Chemical Classes from Natural Products and LC Fingerprints -- Fingerprints for Flavonoids -- Fingerprints for Terpenoids -- Fingerprints for Alkaloids -- Fingerprints for Coumarins -- Fingerprints for Alkamides -- References -- Bibliography -- 5. GC: Herbal Drugs and Fingerprints -- Instrumentation -- GLC Columns -- Detectors in GLC -- Development of GC Fingerprints and Data Interpretation -- Sample Preparation -- Separation and Detection -- Analytical Results -- Utility of GC Fingerprints in Herbal Drugs -- Contamination/Adulteration -- Traceability -- Qualification and Quantification of Therapeutics -- Nutraceutical Discovery -- New Cosmeceuticals -- In Aromatherapy -- To Decipher Traditional Formulations -- References -- Bibliography -- Pt. III. Herbal Drugs and Spectral Fingerprints -- 6. UV-Vis. Spectroscopy: Herbal Drugs and Fingerprints -- Instrumentation -- UV-Vis. Spectrometry and Herbal Drugs -- To Study the Phenolics and Derivatives -- UV Spectrometry for Different Derivatives -- UV-Vis. Coupled Methods for Analysis -- Preparation of Sunscreens -- Evaluation of Vitamin C Content -- Preparation of Stock Solutions -- Green Synthesis of Nanoparticles -- SNPs from C. tamala Twigs -- Purification of Geometrical Isomers -- Analysis of Ultra-Diluted Drugs -- Identification of Powdered Medicinal Plants -- Biological Assay Using Hyphenated Techniques -- To Differentiate Various Species of a Genus -- References -- Bibliography -- 7. FTIR Spectroscopy: Herbal Drugs and Fingerprints -- Interpretation of IR Spectra -- Authentication of Herbal and Herbal Drugs -- Interpretation of Data -- Identification and Comparison of Biomolecules -- Authenticity of Herbal and Herbal Drugs -- To Distinguish Herb from Its Morphological Fakes -- Standardization of Metal-Based Herbal Drugs -- References -- Bibliography -- 8. Mass Spectroscopy: Herbal Drugs and Fingerprints -- Interpretation of Mass Spectra -- Techniques for Analysis of Ions in MS -- Detection and Recording of Fingerprints -- Electrospray MS for Herbal Fingerprints -- Matrix-Assisted Laser Desorption Ionization -- Hyphenated Techniques -- References -- Bibliography -- 9. NMR Spectroscopy: Herbal Drugs and Fingerprints -- Metabolic Fingerprints -- Case Study 1 -- 1H-NMR Detection -- 1H-NMR Spectra to Recognize Patterns and Find Discriminating Signals -- 2D-NMR Spectroscopy to Compare Metabolites -- Evaluation of Quality of High Therapeutic-Value Herbals -- Case Study 2 -- Materials and Chemicals -- Molecular Modeling -- Case Study 3 -- To Decipher the Herbal Constituents -- Case Study 4 -- Metabolic Fingerprints to Distinguish Plant Species -- Case Study 5 -- Quality Assurance of Traditional Medicines -- Case Study 6 -- Detection of Contaminations -- References -- Bibliography -- Pt. IV. Pollutants in Herbal Drugs and Fingerprints -- 10. Metals in Herbal Drugs and Fingerprints -- Atomic Absorption Spectroscopy -- Instrumentation in AAS -- Case Study 1 -- Case Study 2 -- Graphite Furnace Atomizer -- Inductively Coupled Plasma -- WDXRF Spectroscopy -- Heavy Metals -- Removal of Heavy Metals from Herbal Drugs -- Case Study 3 -- Bhasmas as Nanoherbal Drugs -- References -- Bibliography -- 11. Pesticide Residues in Herbals and Detection -- Regulatory Norms -- Analysis of Pesticide Residues -- Isolation and Purification Methods -- Hyphenated Techniques for Isolation and Purification -- Contemporary Trends in Pesticide Residue Analysis -- Degree of Uncertainty of Analysis -- Pesticides Residues in Natural Products -- Current Scenario of Pesticides Residues in Herbals -- Pesticide Residues in Dry Fruits -- TLC Fingerprints -- GC Fingerprints -- References -- Bibliography -- 12. Radiation Detection in Herbals -- Microorganisms in Herbals -- Safety and Effectiveness of Irradiation -- Irradiation of Spices and Dried Vegetable Seasonings -- Irradiation Dose for Essential Oils and Organoleptic Characters -- Radiation Quantity and Antioxidant Activity -- Detection of Irradiated Foods and Food Supplements -- Thermoluminescence -- Pulse Photo-Stimulated Luminescence -- Electron Paramagnetic Spin Resonance Spectroscopy -- References -- Bibliography -- Pt. V. DNA Techniques for Evidence-Based Herbals -- 13. Herbal Drugs and DNA Fingerprints -- Authentication of Traditional Formulations -- Experimental Details -- RAPD Reaction -- Identification of Chemotypes, Ecotypes, and Substitutes -- Case Study -- Identification of Adulterants -- DNA Fingerprint Techniques for Identification of Ingredients -- Polymerase Chain Reaction -- Simple Sequence Repeats -- Restriction Fragment Length Polymorphisms -- Amplified Fragment Length Polymorphism -- Random Amplified Polymorphism -- Single-Nucleotide Polymorphism -- Short Tandem Repeat -- DNA Barcode -- Genetic Markers -- Trouble Shooting in DNA Fingerprinting -- Commercial Utility of Genetic Markers in Herbal Technology -- Comparative Genetic Analysis -- Future Scope of Genetic Markers in Herbal Drug Research -- References -- Bibliography.
Format
e-Book
Location
Online
Less detail

Informatics for the Clinical Laboratory : A Practical Guide

https://libcat.nshealth.ca/en/permalink/provcat29490
edited by Daniel F. Cowan. --New York, NY: Springer-Verlag , c2005.
Available Online
View e-Book
Location
Online
Available Online
View e-Book
Author
Cowan, Daniel F
Responsibility
edited by Daniel F. Cowan
Place of Publication
New York, NY
Publisher
Springer-Verlag
Date of Publication
c2005
Series Title
Health informatics
ISBN
9780387226293
Subjects (MeSH)
Clinical Laboratory Information Systems
Subjects (LCSH)
Medical records - Data processing
Medical laboratories
Format
e-Book
Location
Online
Less detail

Laboratory Guide to the Methods in Biochemical Genetics

https://libcat.nshealth.ca/en/permalink/provcat28397
edited by Nenad Blau, Marinius Duran, K. Michael Gibson. --Berlin, Heidelberg: Springer-Verlag , c2008.
Available Online
View e-Book
Location
Online
Available Online
View e-Book
Author
Blau, Nenad
Other Authors
Duran, Marinius
Gibson, K. Michael
Responsibility
edited by Nenad Blau, Marinius Duran, K. Michael Gibson
Place of Publication
Berlin, Heidelberg
Publisher
Springer-Verlag
Date of Publication
c2008
ISBN
9783540766988
Subjects (MeSH)
Metabolism, Inborn Errors - diagnosis - Laboratory Manuals
Molecular Biology - methods - Laboratory Manuals
Subjects (LCSH)
Genetics
Medical laboratories
Biochemistry
Format
e-Book
Location
Online
Less detail

Modern Clinical Molecular Techniques

https://libcat.nshealth.ca/en/permalink/provcat30958
Peter Hu, Madhuri Hegde, Patrick Alan Lennon, editors. --New York, NY: Springer , c2012.
Available Online
View e-Book
Location
Online
This timely book covers the need to know clinical practices for all those involved in molecular laboratory science. The field of molecular medicine is evolving at an astounding speed. Propelled by the new insights and technologies, advances are being made at an unprecedented rate. With dual measure given to today's breakthroughs, this book is a collection of the most current practices relevant to the clinical molecular laboratorian. It begins with an introductory section on techniques and proce…
Available Online
View e-Book
Other Authors
Hu, Peter
Hegde, Madhuri
Lennon, Patrick Alan
Responsibility
Peter Hu, Madhuri Hegde, Patrick Alan Lennon, editors
Place of Publication
New York, NY
Publisher
Springer
Date of Publication
c2012
Physical Description
1 online resource (xiii, 436 p. : 60 ill., 41 ill. in color)
ISBN
9781461421702
Subjects (MeSH)
Molecular Diagnostic Techniques
Subjects (LCSH)
Pathology
Medical laboratories
Abstract
This timely book covers the need to know clinical practices for all those involved in molecular laboratory science. The field of molecular medicine is evolving at an astounding speed. Propelled by the new insights and technologies, advances are being made at an unprecedented rate. With dual measure given to today's breakthroughs, this book is a collection of the most current practices relevant to the clinical molecular laboratorian. It begins with an introductory section on techniques and procedure. It then presents four separate sections on infectious disease, oncology, pre/post-natal, and identity testing, with specific chapters clearly outlining clinical protocols used in daily practice. Modern Clinical Molecular Techniques cuts to the heart of what is essential for the practicing molecular laboratory scientist. It is an outstanding resource for those operating within or looking to set up a clinical molecular laboratory.
Contents
Specimen Collection, Handling and Processing -- DNA/RNA Isolation and Quantitation -- Test Validation -- In Vitro Amplification Methods in Molecular Diagnostics -- Whole Genome Sequencing in the Clinical Laboratory -- Estimation of Exon Dosage Using Real-Time Quantitative Polymerase Chain Reaction: Applications to Factor VIII Gene in Hemophilia A and Endoglin/ACVRL1 Genes in Hereditary Hemorrhagic Telangiectasia -- Reporting Clinical Molecular Genetic Laboratory Results -- HIV-1 Genotyping and Virtual Phenotyping -- COBAS® AmpliPrep/COBAS® TaqMan® HIV-1 Test, Version 2.0 -- Hepatitis C Virus (HCV) Genotype Assay (LiPA) -- COBAS® AmpliPrep/COBAS® TaqMan® HCV Test -- Epstein-Barr Virus and Cytomegalovirus Viral Load Monitoring by Quantitative Real-Time Polymerase Chain Reaction -- Quantification of BK Viral Load -- Molecular Diagnosis and Epidemiology of Rabies -- Pyrosequencing for Bacterial Identification -- Other Pathogens of Significant Public Health Concern -- Gene Rearrangements Testing -- Mutation Analysis in Cancer -- Minimal Residual Disease -- Pyrosequencing in Cancer -- Clinical Applications of Microarrays in Cancer -- Basic Theories and Clinical Applications of Molecular Flow Cytometry -- Molecular Prenatal Diagnostic Testing -- PCR Based Diagnosis of Fragile X Syndrome -- Microsatellite Testing Short Tandem Repeat Profile Generation -- Parentage -- Diagnostic Molecular Training -- Molecular Diagnostics Point of Care Testing Training.
Format
e-Book
Location
Online
Less detail

Molecular Diagnostics : For the Clinical Laboratorian

https://libcat.nshealth.ca/en/permalink/provcat29765
edited by William B. Coleman, Gregory J. Tsongalis. --Totowa, NJ: Humana Press , c2005.
Available Online
View e-Book
Location
Online
Available Online
View e-Book
Author
Coleman, William B
Other Authors
Tsongalis, Gregory J
Responsibility
edited by William B. Coleman, Gregory J. Tsongalis
Place of Publication
Totowa, NJ
Publisher
Humana Press
Date of Publication
c2005
ISBN
9781592599288
Subjects (MeSH)
Chemistry, Clinical - methods
Clinical Laboratory Techniques
Genetic techniques
Molecular Biology - methods
Subjects (LCSH)
Genetics
Medical laboratories
Format
e-Book
Location
Online
Less detail

Molecular Imaging : An Essential Tool in Preclinical Research, Diagnostic Imaging, and Therapy

https://libcat.nshealth.ca/en/permalink/provcat29995
edited by A. A. Bogdanov, K. Licha. --Berlin, Heidelberg: Springer , c2005.
Available Online
View e-Book
Location
Online
Available Online
View e-Book
Author
Bogdanov, A. A
Other Authors
Licha, K
Responsibility
edited by A. A. Bogdanov, K. Licha
Place of Publication
Berlin, Heidelberg
Publisher
Springer
Date of Publication
c2005
Series Vol.
49
Series Title
Ernst Schering Research Foundation workshop
ISBN
9783540268093
Subjects (MeSH)
Molecular Biology - methods
Molecular Diagnostic Techniques
Subjects (LCSH)
Radiology, Medical
Diagnostic Imaging
Biochemistry
Medical laboratories
Format
e-Book
Location
Online
Less detail

Molecular surgical pathology

https://libcat.nshealth.ca/en/permalink/provcat32408
Liang Cheng, John N. Eble, editors. --New York, NY: Springer , c2013.
Available Online
View e-Book
Location
Online
Molecular Surgical Pathology provides a concise review of recent advancement of molecular pathology in each organ system. The text is intended as a "first knowledge base" in the rapidly evolving field of molecular pathology and is organized in a user friendly outline format. Each chapter is organ-based and covers important aspects of molecular pathology and its impact on our daily practice of surgical pathology. The topics presented herein constitute the fundamentals and core base of knowledge…
Available Online
View e-Book
Other Authors
Cheng, Liang
Eble, John N
Responsibility
Liang Cheng, John N. Eble, editors
Place of Publication
New York, NY
Publisher
Springer
Date of Publication
c2013
Physical Description
1 online resource (xi, 436 p. : 131 ill., 125 ill. in color)
ISBN
9781461449003
Subjects (MeSH)
Neoplasms - pathology
Pathology, Molecular
Pathology, Surgical
Subjects (LCSH)
Oncology
Medical laboratories
Pathology
Abstract
Molecular Surgical Pathology provides a concise review of recent advancement of molecular pathology in each organ system. The text is intended as a "first knowledge base" in the rapidly evolving field of molecular pathology and is organized in a user friendly outline format. Each chapter is organ-based and covers important aspects of molecular pathology and its impact on our daily practice of surgical pathology. The topics presented herein constitute the fundamentals and core base of knowledge required for the daily practice of surgical pathology. This book focuses on the practical utilities of molecular techniques and molecular biomarkers in daily practice of surgical pathology. The emphasis is on the impact of molecular pathology for tumor classification, diagnosis and differential diagnosis as well as its implications for patient management and personalized care. Numerous tables, diagrams and color illustrations are included throughout. Molecular Surgical Pathology will prove a very useful resource for pathologists in training who are preparing for the Board and in-service examination. It will also be a unique and invaluable resource for medical oncologists, physicians, other medical professionals and basic research scientists with interest in molecular pathology of human cancers.
Contents
Molecular Pathology of Colorectal Cancer -- Molecular Pathology of Pancreatic Cancer -- Molecular Pathology of Liver Tumors -- Molecular Pathology of Gallbladder Cancer -- Molecular Pathology of Lung Cancers -- Molecular Pathology of Breast Cancer -- Molecular Pathology of Ovarian Cancer -- Molecular Pathology of Endometrial Cancer -- Molecular Pathology of Kidney Tumors -- Molecular Pathology of Prostate Cancer -- Molecular Pathology of Urinary Bladder Cancer -- Molecular Pathology of Testicular Cancer -- Molecular Pathology of Cutaneous Melanoma and Nonmelanoma Skin Cancer -- Molecular Pathology of Head and Neck Cancer -- Molecular Pathology of Soft Tissue and Bone Tumors -- Molecular Pathology of the Central Nervous System -- Molecular Pathology of Endocrine Cancers -- Index.
Format
e-Book
Location
Online
Less detail

Molecular typing in bacterial infections

https://libcat.nshealth.ca/en/permalink/provcat32457
Ivano de Filippis, Marian L. McKee, editors. --New York, NY: Humana Press , c2013.
Available Online
View e-Book
Location
Online
The accurate identification and typing of microbes is essential for researchers in all fields of microbiology. The investigation of species diversity is crucial for the determination of the genetic relatedness of isolates for epidemiological studies. The development of molecular genotyping methods has improved the classification and typing of microorganisms at the sub-species level. In Molecular Typing in Bacterial Infections, readers will find an ultimate guide to molecular methods for the cla…
Available Online
View e-Book
Other Authors
de Filippis, Ivano
McKee, Marian L
Responsibility
Ivano de Filippis, Marian L. McKee, editors
Place of Publication
New York, NY
Publisher
Humana Press
Date of Publication
c2013
Physical Description
1 online resource (xii, 482 p. : 40 ill., 10 ill. in color)
Series Title
Infectious disease
ISBN
9781627031851
Subjects (MeSH)
Bacterial Infections
Molecular Epidemiology - methods
Molecular Typing
Subjects (LCSH)
Medical laboratories
Infectious diseases
Microbiology
Bacteriology
Abstract
The accurate identification and typing of microbes is essential for researchers in all fields of microbiology. The investigation of species diversity is crucial for the determination of the genetic relatedness of isolates for epidemiological studies. The development of molecular genotyping methods has improved the classification and typing of microorganisms at the sub-species level. In Molecular Typing in Bacterial Infections, readers will find an ultimate guide to molecular methods for the classification and typing of most human bacterial pathogens, covering a wide range of techniques which can be easily applied to the investigation of infectious diseases. The emphasis is on nucleic acid-based assays and alternative biochemically and immunologically-based formats providing significant potential improvementá of typing technologies that are transforming the field of diagnostic testing. Comprehensive and practical, Molecular Typing in Bacterial Infections provides state-of-the-art methods not only for accurate diagnostic, but also for the correct classification of different types which will prove to be critical in unraveling the routes of spread of human pathogens.
Contents
Section 1: General consideration on microorganism typing methods -- Molecular epidemiology.-Section 2: Gastrointestinal Pathogens -- Enterococci -- Listeria monocytogenes -- Enterobacteriaceae -- Vibrio cholerae -- Clostridium difficile -- Oral and Intestinal Bacteroidetes -- Section 3: Oral and Respiratory Pathogens -- Streptococci -- Streptococcus mutans -- Periodontal anaerobic bacteria -- Nontuberculous mycobacteria -- Neisseria meningitidis -- Haemophilus influenzae -- Moraxella -- Legionella pneumophila -- Mycoplasma and Ureaplasma -- Corynebacterium diphtheriae -- Burkholderia -- Section 4: Urogenital Pathogens -- Treponema -- Chlamydiaceae -- Section 5: Vector Borne Pathogens -- Borreliae -- Erysipelothrix -- Section 6: Pathogens causing Healthcare-Associated Infection -- Staphylococci -- Pseudomonas -- Section 7: Emerging and Reemerging Pathogens -- Acinetobacter baumannii -- Coxiella burnetii -- Index.
Format
e-Book
Location
Online
Less detail

25 records – page 1 of 2.