topic:"Models, Animal" found 25 records - Provincial Hospitals Library Catalogue

Acute Lung Injury and Repair : Scientific Fundamentals and Methods

https://libcat.nshealth.ca/en/permalink/provcat41567

Lynn M. Schnapp, Carol Feghali-Bostwick, editors. --Cham: Humana Press , 2017.

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Location: Online

Acute Respiratory Distress Syndrome (ARDS) remains an important cause of morbidity and mortality worldwide, and the incidence is predicted to increase with the aging population Several clinical disorders can initiate ARDS, including pneumonia, sepsis, gastric aspiration and trauma but despite intense research over the past 40 years, we still have an incomplete understanding of the pathophysiology of the disease and treatment remains largely supportive. This book provides an overview of acute lu…

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Other Authors: Schnapp, Lynn M.; Feghali-Bostwick, Carol

Other Authors: American Thoracic Society

Responsibility: Lynn M. Schnapp, Carol Feghali-Bostwick, editors

Place of Publication: Cham

Publisher: Humana Press

Date of Publication: 2017

Physical Description: 1 online resource (viii, 185 pages) : 23 illus., 20 illus. in color

Series Title: Respiratory medicine

ISBN: 9783319465272; 9783319465258 (print ed.)

ISSN: 2197-7372

Subjects (MeSH): Acute Lung Injury - etiology; Models, Animal; Respiratory Distress Syndrome, Adult - physiopathology

Abstract: Acute Respiratory Distress Syndrome (ARDS) remains an important cause of morbidity and mortality worldwide, and the incidence is predicted to increase with the aging population Several clinical disorders can initiate ARDS, including pneumonia, sepsis, gastric aspiration and trauma but despite intense research over the past 40 years, we still have an incomplete understanding of the pathophysiology of the disease and treatment remains largely supportive. This book provides an overview of acute lung injury and repair, describes current animal models to study lung injury and reviews current methodologies to study and measure lung injury and repair. Special emphasis is given to state of the art techniques and methods and relevance to human disease. Acute Lung Injury and Repair: Scientific Fundamentals and Methods is a useful resource for physicians and scientists who are interested in experimental model systems for insight into ARDS pathogenesis and treatment strategies.

Contents: Methods to Study Lung Injury and Repair -- Mouse Models of Acute Lung Injury -- Transgenic Animal Models in Lung Research -- Fundamental Methods for Analysis of Acute Lung Injury in Mice -- Invasive Measurement of Pulmonary Function in Mice -- Analysis of Epithelial Injury and Repair -- Flow Cytometric Evaluation of Acute Lung Injury and Repair -- Lung Imaging in Animal Models -- Genetic and Genomic Approaches to Acute Lung Injury -- MicroRNA Analysis in Acute Lung Injury.

Format: e-Book

Location: Online

Animal Models of Acute Neurological Injury

https://libcat.nshealth.ca/en/permalink/provcat44654

Jun Chen, Zao C. Xu, Xiao Ming Xu, John H. Zhang, editors. (Second edition) --Cham: Springer , c2019.

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Location: Online

Despite numerous recent studies and exciting discoveries in the field, only limited treatments are available today for the victims of acute brain and spinal cord injuries. Animal Models of Acute Neurological Injuries, Second Edition, provides a standardized methodology manual designed to eliminate the inconsistent preparations and variability that often inhibit advances in this specialized research field. In the 10 years since publication of the first edition of this book, some animal models ha…

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Other Authors: Chen, Jun.; Xu, Zao C.; Xu, Xiao Ming.; Zhang, John H.

Responsibility: Jun Chen, Zao C. Xu, Xiao Ming Xu, John H. Zhang, editors

Edition: Second edition

Place of Publication: Cham

Publisher: Springer

Date of Publication: c2019

Physical Description: 1 online resource (x, 544 p.) : 176 illus.

Series Title: Springer series in translational stroke research

ISBN: 9783030160821; 9783030160807 (Print ed.); 9783030160814 (Print ed.)

ISSN: 2363-958X

Subjects (MeSH): Disease Models, Animal; Trauma, Nervous System - physiopathology

Specialty: Neurology; Traumatology

Abstract: Despite numerous recent studies and exciting discoveries in the field, only limited treatments are available today for the victims of acute brain and spinal cord injuries. Animal Models of Acute Neurological Injuries, Second Edition, provides a standardized methodology manual designed to eliminate the inconsistent preparations and variability that often inhibit advances in this specialized research field. In the 10 years since publication of the first edition of this book, some animal models have become obsolete, some have stood the test of time, and newer models have emerged to enhance our knowledge of acute neurological injuries. The second edition continues to offer the research community tested approaches for this area of investigation. As with the first edition, top experts have developed and contributed these animal models. The book’s focus remains hands-on, practical applications of the models, rather than a theoretical approach. Each chapter contains a proven procedure enhanced by clear figures, illustrations, or videos. This new edition presents its readily reproducible protocols with clarity and consistency to best aid neuroscientists and neurobiologists. As with the first edition, the second edition is comprehensive and cutting-edge. Animal Models of Acute Neurological Injuries, Second Edition, is an ideal guide for research professionals, at all stages of their careers, who wish to pursue this vital course of study with the proficiency and precision required by the field.

Contents: Part I. Animal Care and Surgery -- Animal Protocol -- Anesthesia and Analgesia for Research Animals -- Rodent Surgical Procedures and Tissue Collection -- Brain Monitoring -- Veterinary Care Methods for Rats and Mice in Experimental Spinal Cord Injury Studies: An Update -- Part II. Cerebral Ischemic Animal Models -- Four Vessel-Occlusion Model in Rats -- Rat Model of Global Cerebral Ischemia: Two Vessel-Occlusion (2VO) Model of Forebrain Ischemia -- Rodent Model of Pediatric Asphyxial Cardiac Arrest -- Transient Middle Cerebral Artery Occlusion Model in Rodents -- Targeted Occlusion to Surface and Deep Vessels in Neocortex Via Linear and Nonlinear Optical Absorption -- Intraluminal Middle Cerebral Artery Occlusion Model in Mice -- Inducing Hemorrhagic Transformation following Middle Cerebral Artery Occlusion via Acute Hyperglycemia in Rats -- Cerebral Palsy Model of Uterine Ischemia -- Model of Neonatal Focal Cerebral Ischemia-Reperfusion -- Cerebral Hemorrhage Animal Models -- Part III. Monofilament Perforation Subarachnoid Hemorrhage Rat Model -- Filament Perforation Subarachnoid Hemorrhage Mouse Model -- Non-Human Primate Model of Cerebral Vasospasm -- Blood Injection Intracerebral Hemorrhage Rat Model -- Collagenase Model of Intracerebral Hemorrhage in Rats -- A Rat Model of Cerebellar Hemorrhage using Bacterial Collagenase Injection -- Blood Injection Intracerebral Hemorrhage Mouse Model -- Blood Injection Intracerebral Hemorrhage Pig Model -- Collagenase Induced Pontine Hemorrhage in Rats -- Germinal Matrix Hemorrhage Neonatal Rat Model Using Bacterial Collagenase Injection -- Part IV. Traumatic CNS Injury Animal Models -- Fluid Percussion Injury Model -- Controlled Cortical Impact Model of Experimental Brain Trauma -- Mild Blast-induced Traumatic Brain Injury Model -- Rat Model of Surgical Brain Injury -- MASCIS Spinal Cord Contusion Model -- ESCID Spinal Cord Contusion Model -- Cervical Hemicontusion Spinal Cord Injury Model -- Applications of the Infinite Horizon Spinal Cord Contusion Injury Model -- Clip Impact-Compression Model -- Method of Spinal Cord Contusion Injury Created by Tissue Displacement -- Experimental Laceration Spinal Cord Injury Model in Rodents -- Rodent Spinal Cord Demyelination Models -- Spinal Cord Lateral Hemisection and Implantation of Guidance Channels -- Spinal Root Avulsion and Repair.

Format: e-Book

Location: Online

Animal Models of Ophthalmic Diseases

https://libcat.nshealth.ca/en/permalink/provcat39799

Chi-Chao Chan, editor. (1st ed.) --Cham: Springer , c2016.

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Location: Online

This book describes experimental animal models that mimic common human ocular diseases: herpetic keratitis, cataract, glaucoma, age-related macular degeneration, diabetic retinopathy, uveitis, retinitis pigmentosa, Graves' disease, and intraocular tumors. In conjunction, these models reflect the diversity and utility of tools used to study human disease. World expert clinicians discuss each model based on their clinical experience, and the text is supported by numerous photos and diagrams. Deve…

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Other Authors: Chan, Chi-Chao

Responsibility: Chi-Chao Chan, editor

Edition: 1st ed.

Place of Publication: Cham

Publisher: Springer

Date of Publication: c2016

Physical Description: 1 online resource (xv, 152 p. : 13 illus. in color)

Series Title: Essentials in ophthalmology

ISBN: 9783319194349; 9783319194332 (print ed.)

ISSN: 1612-3212

Subjects (MeSH): Disease Models, Animal; Eye Diseases

Abstract: This book describes experimental animal models that mimic common human ocular diseases: herpetic keratitis, cataract, glaucoma, age-related macular degeneration, diabetic retinopathy, uveitis, retinitis pigmentosa, Graves' disease, and intraocular tumors. In conjunction, these models reflect the diversity and utility of tools used to study human disease. World expert clinicians discuss each model based on their clinical experience, and the text is supported by numerous photos and diagrams. Development of suitable experimental models is critical in identifying risk factors for disease, elucidating fundamental molecular mechanisms in disease progression, and providing guidance as to whether or not a particular treatment is safe and effective for humans. Like other forms of medical research, ophthalmology and vision research focuses on the investigation of disease pathogenesis and the discovery of novel therapies through in vitro and in vivo methodology. The in vivo experiments employ animal models including vertebrates (zebrafish, rodents, rabbits, and primates) and invertebrates (fruit flies and nematodes) for drug screening. In describing the most pertinent animal models of ophthalmic diseases, this book will be of interest to ophthalmologists, vision researchers, fellows, residents, and medical students.

Format: e-Book

Location: Online

Animal models of T cell-mediated skin diseases

https://libcat.nshealth.ca/en/permalink/provcat28765

--Berlin, Heidelberg: Springer , c2005.

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Location: Online

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Other Authors: Zollner, T; Renz, H; Asadullah, K

Place of Publication: Berlin, Heidelberg

Publisher: Springer

Date of Publication: c2005

Series Vol.: 50

Series Title: Ernst Schering Research Foundation workshop

ISBN: 9783540268116

Subjects (MeSH): Disease Models, Animal; Skin Diseases - physiopathology

Subjects (LCSH): Dermatology

Format: e-Book

Location: Online

Atlas of Airway Surgery : A Step-by-Step Guide Using an Animal Model

https://libcat.nshealth.ca/en/permalink/provcat41629

Angelo Ghidini, Francesco Mattioli, Sergio Bottero, Livio Presutti, editors. --Cham: Springer , 2017.

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Location: Online

This superbly illustrated atlas provides step-by-step descriptions of surgical procedures to the airways based on use of the sheep as an animal model, which has been demonstrated scientifically to be comparable to the human. The procedures covered--tracheotomy, laryngotracheoplasty, slide tracheoplasty, tracheal reconstruction, partial cricotracheal reconstruction, and main endoscopic techniques--are relevant to a range of frequent surgical indications, such as stenosis, laryngotracheomalacia, …

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Other Authors: Ghidini, Angelo; Mattioli, Francesco; Bottero, Sergio; Presutti, Livio

Responsibility: Angelo Ghidini, Francesco Mattioli, Sergio Bottero, Livio Presutti, editors

Place of Publication: Cham

Publisher: Springer

Date of Publication: 2017

Physical Description: 1 online resource (vii, 123 pages) : 185 illus. in color

ISBN: 9783319497396; 9783319497389 (print ed.)

Subjects (MeSH): Models, Animal; Respiratory System - surgery; Surgical Procedures, Operative - methods

Abstract: This superbly illustrated atlas provides step-by-step descriptions of surgical procedures to the airways based on use of the sheep as an animal model, which has been demonstrated scientifically to be comparable to the human. The procedures covered--tracheotomy, laryngotracheoplasty, slide tracheoplasty, tracheal reconstruction, partial cricotracheal reconstruction, and main endoscopic techniques--are relevant to a range of frequent surgical indications, such as stenosis, laryngotracheomalacia, and tracheal tumor. The book is the first to describe such surgery on the basis of this animal model and includes a full description of preparation of the model. The practical guidance provided will equip surgical trainees with the knowledge required before embarking on these procedures in humans, but will also be highly relevant to more experienced surgeons wishing to upgrade their skills. The book is the outcome of a successful collaboration between the Head and Neck Surgery Departments of the University Hospital of Modena and the Bambino Gesù Hospital in Rome.

Contents: 1. Anatomy of Animal Model and Comparison to Human -- 2. How to Prepare an Animal Model -- 3. Tracheotomy -- 4. Laryngotracheoplasty (Anterior and Posterior Cricoid Split) -- 5. Slide Tracheoplasty -- 6. Step-by-Step Tracheal Resection with End-to-End Anastomosis -- 7. Step-by-Step Partial Cricotracheal Resection (PCTR) -- 8. Larynx Box -- 9. Endoscopic Procedures.

Format: e-Book

Publication Type: Atlas

Location: Online

The Basal Ganglia IX

https://libcat.nshealth.ca/en/permalink/provcat29244

edited by Hendrik Jan Groenewegen, Pieter Voorn, Henk W. Berendse, Antonius B. Mulder, Alexander R. Cools. --New York, NY: Springer-Verlag , c2009.

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Location: Online

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Author: Groenewegen, Hendrik Jan

Other Authors: Voorn, Pieter; Berendse, Henk W; Mulder, Antonius B; Cools, Alexander R

Responsibility: edited by Hendrik Jan Groenewegen, Pieter Voorn, Henk W. Berendse, Antonius B. Mulder, Alexander R. Cools

Place of Publication: New York, NY

Publisher: Springer-Verlag

Date of Publication: c2009

Series Vol.: 58

Series Title: Advances in behavioral biology

ISBN: 9781441903402

Subjects (MeSH): Basal Ganglia - physiology; Basal Ganglia - drug effects; Basal Ganglia Diseases; Disease Models, Animal

Subjects (LCSH): Neurosciences

Format: e-Book

Location: Online

The Blood Brain Barrier and Inflammation

https://libcat.nshealth.ca/en/permalink/provcat41542

Ruth Lyck, Gaby Enzmann, editors. --Cham: Springer , 2017.

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Location: Online

Within the central nervous system (CNS) the constantly changing blood stream is separated from the CNS parenchyma by the blood brain barrier (BBB) restricting passage to selected immune cells. Under pathological conditions, however, viruses, bacteria, parasites and autoaggressive immune cells can penetrate the barrier and contribute to CNS inflammation. The BBB actively contributes to neuroinflammation by presentation of chemokines, expression of cell adhesion molecules and alteration of barrie…

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Other Authors: Lyck, Ruth; Enzmann, Gaby

Responsibility: Ruth Lyck, Gaby Enzmann, editors

Place of Publication: Cham

Publisher: Springer

Date of Publication: 2017

Physical Description: 1 online resource (vi, 286 pages) : 32 illus., 24 illus. in color

Series Title: Progress in inflammation research

ISBN: 9783319455143; 9783319455129 (print ed.)

Subjects (MeSH): Blood-Brain Barrier - physiopathology; Central Nervous System Diseases - metabolism; Models, Animal; Neurogenic Inflammation - metabolism

Abstract: Within the central nervous system (CNS) the constantly changing blood stream is separated from the CNS parenchyma by the blood brain barrier (BBB) restricting passage to selected immune cells. Under pathological conditions, however, viruses, bacteria, parasites and autoaggressive immune cells can penetrate the barrier and contribute to CNS inflammation. The BBB actively contributes to neuroinflammation by presentation of chemokines, expression of cell adhesion molecules and alteration of barrier properties. As such, understanding the role of the BBB under healthy and pathological conditions is essential for the development of new drugs to efficiently combat inflammatory diseases of the CNS. This book presents a comprehensive collection of reviews that focus on the role of the BBB. Experts in the field share their insight on structural, topological and functional properties of the BBB. They elaborate on pathophysiological changes of the inflamed BBB such as permeability, transporter proteins and alterations in microRNAs and cytokine profile. Additional chapters on multiple sclerosis and bacterial meningitis provide in depth information on significant neuroinflammatory diseases. The selection is complemented by a review on the current understanding of the BBB as signaling hub in tumor pathogenesis in the brain.

Contents: General Introduction to Barrier Mechanisms in the Central Nervous System -- Topological Aspects of the Blood-Brain and Blood-Cerebrospinal Fluid Barriers and their Relevance in Inflammation Research -- The Contribution of the Extracellular Matrix to the BBB in Steady State and Inflammatory Conditions -- Pathophysiology of the Bloodbrain Barrier in Neuroinflammatory Diseases -- Leakage at Blood-neural Barriers -- Blood-Brain Barrier Transporters and Neuroinflammation: Partners in Neuroprotection and in Pathology -- MicroRNAs in Brain Endothelium and Inflammation -- Blood-Brain Barrier Dysfunction during Central Nervous System Autoimmune Diseases -- Pathways Across the Blood Brain Barrier -- Neuroinflammation in Bacterial Meningitis -- Blood Vessels in the Brain: a Signaling Hub in Brain Tumor Inflammation.

Format: e-Book

Location: Online

Handbook of laboratory animal science : Volume 3, animal models

https://libcat.nshealth.ca/en/permalink/provcat32936

edited by Jann Hau, Steven J. Schapiro. (3rd ed.) --Boca Raton, FL: CRC Press/Taylor & Francis Group , 2011.

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The three Rs have been integrated throughout this handbook to promote efficient and humane experimental work with animals. Written by international experts, each chapter focuses on an important subdiscipline of laboratory animal science and can be used as a stand-alone text. This volume contains new chapters for six additional disease animal models: spinal cord injury, cardiovascular diseases, sudden infant death syndrome, developmental disorders, eye diseases, and human cancer. It also present…

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Other Authors: Hau, Jann; Schapiro, Steven Jay

Responsibility: edited by Jann Hau, Steven J. Schapiro

Edition: 3rd ed.

Alternate Title: Animal models

Place of Publication: Boca Raton, FL

Publisher: CRC Press/Taylor & Francis Group

Date of Publication: 2011

Physical Description: 1 online resource (330 pages)

ISBN: 9781466555129

Subjects (MeSH): Animal Welfare - handbook; Animals, laboratory - handbook; Disease models, animal - handbook

Abstract: The three Rs have been integrated throughout this handbook to promote efficient and humane experimental work with animals. Written by international experts, each chapter focuses on an important subdiscipline of laboratory animal science and can be used as a stand-alone text. This volume contains new chapters for six additional disease animal models: spinal cord injury, cardiovascular diseases, sudden infant death syndrome, developmental disorders, eye diseases, and human cancer. It also presents a new chapter on applying reduction and refinement to animal models. This handbook can be used for undergraduate and postgraduate laboratory animal science courses, and as a handbook for scientists who work with animals in their research, for university veterinarians, for regulators, and for other specialists in laboratory animal science.

Contents: Animal Models of Spinal Cord Injury -- Animal Models for Tropical Parasitic Diseases -- Animal models of cardiovascular disease -- Animal Models of Sudden Infant Death Syndrome -- More Animal Models of Developmental Processes and Developmental Disorders for Social Genomics and Beyond -- Animal Models of Metabolic and Inflammatory Diseases -- Animal Models for Eye Diseases -- Animal Models of Human Cancer -- Reduction and Refinement Applied to Animal Models.

Format: e-Book

Location: Online

In Vivo Models of Inflammation. Volume I

https://libcat.nshealth.ca/en/permalink/provcat40557

Christopher S. Stevenson, Lisa A. Marshall, Douglas W. Morgan, editors. (2nd ed.) --Basel: Birkhäuser Verlag , c2006.

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Location: Online

In Vivo Models of Inflammation provides the biomedical researcher in both the pharmaceutical industry and academia with a description of the state of the art animal model systems used to emulate diseases with components of inflammation. This second edition acts as a complement to the first edition by describing and updating the standard models that are most utilized for specific disease areas. In addition, new models are included exploring emerging areas of inflammation research. The format is …

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Other Authors: Stevenson, Christopher S; Marshall, Lisa A; Morgan, Douglas W

Responsibility: Christopher S. Stevenson, Lisa A. Marshall, Douglas W. Morgan, editors

Edition: 2nd ed.

Place of Publication: Basel

Publisher: Birkhäuser Verlag

Date of Publication: c2006

Physical Description: 1 online resource (xii, 207 p.)

Series Title: Progress in inflammation research

ISBN: 9783764375201; 9783764375195 (print ed.)

Subjects (MeSH): Animal Experimentation - standards; Disease Models, Animal; Inflammation

Abstract: In Vivo Models of Inflammation provides the biomedical researcher in both the pharmaceutical industry and academia with a description of the state of the art animal model systems used to emulate diseases with components of inflammation. This second edition acts as a complement to the first edition by describing and updating the standard models that are most utilized for specific disease areas. In addition, new models are included exploring emerging areas of inflammation research. The format is designed with the laboratory in mind: Both volumes provide detailed descriptions of the methodologies and uses of the most significant models. This includes current information regarding agents that demonstrate efficacy, those that do not and those that can be used as standard controls. The focus remains on those models that serve as pre-clinical correlates to human disease as well as those that represent components of the inflammatory response. Pioneering ideas and provocative comments about future directions are meant to challenge the status quo and stimulate new thinking. Therefore, new approaches to the development of future models in selected therapeutic areas have been highlighted. The focus on novel technologies that are vital for innovative in vivo research has been expanded to include chapters on the use of transgenic and gene transfer technologies, nanotechnology, and stem cells. This up-to-date reference manual helps to select the best animal model for a specific question. At the same time, this set of books continues to acknowledge the solemn responsibility in vivo research carries with it and extends the coverage of animal respect and welfare when used in experimental settings. Chapters describing current regulations in the United States, United Kingdom, and Japan address these concerns. Thus, the ultimate aim of this set of books is to provide current best practices for obtaining the maximum information from in vivo experimentation, while preserving the dignity and comfort of the animal.

Contents: Rat models of arthritis: Similarities, differences, advantages, and disadvantages in the identification of novel therapeutics -- Murine collagen induced arthritis -- Use of animal models of osteoarthritis in the evaluation of potential new therapeutic agents -- Models of inflammatory processes in cancer -- Advances in stem cell research: use of stem cells in animal models of muscular dystrophy -- Gene transfer technology -- Transgenics -- Nanotechnology: Towards the detection and treatment of inflammatory diseases -- UK legislation of in vivo aspects in inflammation research -- Japanese guidelines and regulations for scientific and ethical animal experimentation -- United States guidelines and regulations in animal experimentation.

Format: e-Book

Location: Online

In Vivo Models of Inflammation. Volume II

https://libcat.nshealth.ca/en/permalink/provcat40558

Christopher S. Stevenson, Lisa A. Marshall, Douglas W. Morgan, editors. (2nd ed.) --Basel: Birkhäuser Verlag , c2006.

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Location: Online

In Vivo Models of Inflammation provides the biomedical researcher in both the pharmaceutical industry and academia with a description of the state of the art animal model systems used to emulate diseases with components of inflammation. This second edition acts as a complement to the first edition by describing and updating the standard models that are most utilized for specific disease areas. In addition, new models are included exploring emerging areas of inflammation research. The format is …

Available Online: View e-Book

Other Authors: Stevenson, Christopher S; Marshall, Lisa A; Morgan, Douglas W

Responsibility: Christopher S. Stevenson, Lisa A. Marshall, Douglas W. Morgan, editors

Edition: 2nd ed.

Place of Publication: Basel

Publisher: Birkhäuser Verlag

Date of Publication: c2006

Physical Description: 1 online resource (x, 203 p. : 19 illus.)

Series Title: Progress in inflammation research

ISBN: 9783764377601; 9783764377571 (print ed.)

Subjects (MeSH): Disease Models, Animal; Inflammation

Abstract: In Vivo Models of Inflammation provides the biomedical researcher in both the pharmaceutical industry and academia with a description of the state of the art animal model systems used to emulate diseases with components of inflammation. This second edition acts as a complement to the first edition by describing and updating the standard models that are most utilized for specific disease areas. In addition, new models are included exploring emerging areas of inflammation research. The format is designed with the laboratory in mind: Both volumes provide detailed descriptions of the methodologies and uses of the most significant models. This includes current information regarding agents that demonstrate efficacy, those that do not and those that can be used as standard controls. The focus remains on those models that serve as pre-clinical correlates to human disease as well as those that represent components of the inflammatory response. Pioneering ideas and provocative comments about future directions are meant to challenge the status quo and stimulate new thinking. Therefore, new approaches to the development of future models in selected therapeutic areas have been highlighted. The focus on novel technologies that are vital for innovative in vivo research has been expanded to include chapters on the use of transgenic and gene transfer technologies, nanotechnology, and stem cells. This up-to-date reference manual helps to select the best animal model for a specific question. At the same time, this set of books continues to acknowledge the solemn responsibility in vivo research carries with it and extends the coverage of animal respect and welfare when used in experimental settings. Chapters describing current regulations in the United States, United Kingdom, and Japan address these concerns. Thus, the ultimate aim of this set of books is to provide current best practices for obtaining the maximum information from in vivo experimentation, while preserving the dignity and comfort of the animal.

Contents: Asthma -- In vivo modeling systems for chronic obstructive pulmonary disease -- Murine models of allergen-induced airway hyperresponsiveness and inflammation -- Skin inflammatory disorders -- In vivo models of neurogenic inflammation -- Animal models of inflammatory bowel disease -- Preclinical models of vascular inflammation.

Format: e-Book

Location: Online

Mouse Models of Vascular Diseases

https://libcat.nshealth.ca/en/permalink/provcat40414

Masataka Sata, editor. (1st ed.) --Tokyo: Springer Japan , c2016.

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Location: Online

This book is a methodological source on mice models of vascular diseases. Covering various areas, each chapter is written by a pioneering researcher who has developed an original vascular disease model. Notoriously difficult to reproduce, each model is described in detail and numerous photographs are provided with links to videos. Genetically modified mice are a very powerful tool for studying the pathogenesis of various diseases, including immunological and oncological disorders, but they had …

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Other Authors: Sata, Masataka

Responsibility: Masataka Sata, editor

Edition: 1st ed.

Place of Publication: Tokyo

Publisher: Springer Japan

Date of Publication: c2016

Physical Description: 1 online resource (viii, 296 p. : 91 illus., 28 illus. in color)

ISBN: 9784431558132; 9784431558118 (print ed.)

Subjects (MeSH): Disease Models, Animal; Mice; Vascular Diseases - physiopathology

Abstract: This book is a methodological source on mice models of vascular diseases. Covering various areas, each chapter is written by a pioneering researcher who has developed an original vascular disease model. Notoriously difficult to reproduce, each model is described in detail and numerous photographs are provided with links to videos. Genetically modified mice are a very powerful tool for studying the pathogenesis of various diseases, including immunological and oncological disorders, but they had always been thought to be too small to be used in the field of cardiovascular disease. Recently, however, various mice models of vascular diseases have been reported, and these will make a substantial contribution to basic research on cardiovascular and metabolic disorders.

Contents: Part I. Re-stenosis Models After Angioplasty -- Wire-mediated endovascular injury that induces rapid onset of medial cell apoptosis followed by reproducible neointimal hyperplasia -- Cuff-induced neointima formation in mouse models -- Ligation of the Mouse Common Carotid Artery -- Photochemically Induced Endothelial Injury -- Part II. Thrombosis and Hemostasis Models -- Murine Models of Thrombosis and Hemostasis -- Part III. Transplant-Associated Atherosclerosis -- Murine Heart Transplantation and Graft Arterial Disease -- Murine Models of Vein Grafting -- Part IV. Hyperlipidemia-Induced Atherosclerosis -- Mouse Models of Atherosclerosis -- Part V. Aneurysm in the Aorta -- Angiotensin II-induced Aortic Aneurysms in Mice -- Mouse model of abdominal aortic aneurysm induced by CaCl2 -- Mouse models of aortic aneurysm (tentative) -- Part VI. Intracranial Aneurysm Models -- Technical aspects of mouse intracranial aneurysm model -- Experimental model of cerebral aneurysms in ovariectomized rats -- Part VII. Vascular Disease in Cerebral Arteries -- A model of stroke and vascular injury in the brain -- Part VIII. Kawasaki Disease -- Analysis of Kawasaki disease using a mouse model, CAWS vasculitis in DBA/2 mice, induced with a water-soluble extracellular polysaccharide fraction obtained from Candida albicans.

Format: e-Book

Location: Online

Murine Models, Energy Balance, and Cancer

https://libcat.nshealth.ca/en/permalink/provcat39257

Nathan A. Berger, editor. --Cham: Springer , c2015.

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Location: Online

This volume provides a transdisciplinary and translational review of many of the leading murine models used to study the mechanisms, mediators and biomarkers linking energy balance to cancer. It provides a review of murine models that should be of interest to basic, clinical and applied research investigators as well as nutrition scientists and students that work in cancer prevention, cancer control and treatment. The worldwide obesity pandemic has been extensively studied by epidemiologic and …

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Other Authors: Berger, Nathan A

Responsibility: Nathan A. Berger, editor

Place of Publication: Cham

Publisher: Springer

Date of Publication: c2015

Physical Description: 1 online resource (xv, 295 p. : 40 illus., 36 illus. in color)

Series Vol.: 10

Series Title: Energy balance and cancer

ISBN: 9783319167336; 9783319167329 (print ed.)

ISSN: 2199-2622

Subjects (MeSH): Biomarkers; Disease Models, Animal; Energy metabolism; Mice; Neoplasms - etiology; Obesity - complications

Abstract: This volume provides a transdisciplinary and translational review of many of the leading murine models used to study the mechanisms, mediators and biomarkers linking energy balance to cancer. It provides a review of murine models that should be of interest to basic, clinical and applied research investigators as well as nutrition scientists and students that work in cancer prevention, cancer control and treatment. The worldwide obesity pandemic has been extensively studied by epidemiologic and observational studies and even, in some cases, by randomized controlled trials. However, the development and control of obesity, its comorbidities and its impact on cancer usually occurs over such long periods that it is difficult, if not impossible to conduct randomized controlled trials in humans to investigate environmental contributions to obesity, energy balance and their impact on cancer. In contrast, model organisms, especially mice and rats, provide valuable assets for performing these studies under rigorously controlled conditions and in sufficient numbers to provide statistically significant results. In this volume, many of the leading and new murine models used to study the mechanisms and mediators linking cancer with obesity, sleep, exercise, their modification by environment and how they may continue to be used to further elucidate these relations as well as to explore preclinical aspects of prevention and/or therapeutic intervention are considered. This volume provides an important compilation and analysis of major experimental systems and principles for further preclinical research with translational impact on energy balance and cancer.

Contents: Relevance of Circadian Rhythm in Cancer -- Environmental Manipulation and Neuropeptide Effects on Energy Balance and Cancer -- The MRL Mouse: A Model of Regeneration and Cancer -- Living Large: What Mouse Models Reveal about Growth Hormone and Obesity -- Mouse Models to Study Obesity Effects on Hematologic Malignancies -- Energy Balance, IGF-1 and Cancer: Causal Lessons from Genetically Engineered Mice -- Mouse Models to Study Leptin in Breast Cancer Stem Cells -- Mouse Models used to study the effects of Diabetes, Insulin and IGFs on cancer -- Impact of Energy Balance on Chemically Induced Mammary Carcinogenesis in a Rat -- Models and Mechanisms of High Fat Diet Promotion of Pancreatic Cancer -- Maternal energetics and the developmental origins of prostate cancer in offspring -- Mouse Models to Study the Effect of Natural Products on Obesity-Associated NAFLD/NASH -- Mouse Models to Study Metformin Effects in Carcinogenesis.

Format: e-Book

Location: Online

Neuroethics and Nonhuman Animals

https://libcat.nshealth.ca/en/permalink/provcat45237

L. Syd M Johnson, Andrew Fenton, Adam Shriver, editors. --Cham: Springer , c2020.

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Location: Online

This edited volume represents a unique addition to the available literature on animal ethics, animal studies, and neuroethics. Its goal is to expand discussions on animal ethics and neuroethics by weaving together different threads: philosophy of mind and animal minds, neuroscientific study of animal minds, and animal ethics. Neuroethical questions concerning animals’ moral status, animal minds and consciousness, animal pain, and the adequacy of animal models for neuropsychiatric disease have l…

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Other Authors: Johnson, L. Syd M.; Fenton, Andrew; Shriver, Adam

Responsibility: L. Syd M Johnson, Andrew Fenton, Adam Shriver, editors

Place of Publication: Cham

Publisher: Springer

Date of Publication: c2020

Physical Description: 1 online resource (xix, 310 p.) : 12 illus., 8 illus. in color

Series Title: Advances in neuroethics

ISBN: 9783030310110; 9783030310103 (Print ed.); 9783030310127 (Print ed.); 9783030310134 (Print ed.)

ISSN: 2522-5677

Subjects (MeSH): Animal Rights; Animal Welfare; Bioethical Issues; Models, Animal; Neurosciences - ethics

Specialty: Ethics

Abstract: This edited volume represents a unique addition to the available literature on animal ethics, animal studies, and neuroethics. Its goal is to expand discussions on animal ethics and neuroethics by weaving together different threads: philosophy of mind and animal minds, neuroscientific study of animal minds, and animal ethics. Neuroethical questions concerning animals’ moral status, animal minds and consciousness, animal pain, and the adequacy of animal models for neuropsychiatric disease have long been topics of debate in philosophy and ethics, and more recently also in neuroscientific research. The book presents a transdisciplinary blend of voices, underscoring different perspectives on the broad questions of how neuroscience can contribute to our understanding of nonhuman minds, and on debates over the moral status of nonhuman animals. All chapters were written by outstanding scholars in philosophy, neuroscience, animal behavior, biology, neuroethics, and bioethics, and cover a range of issues and species/taxa. Given its scope, the book will appeal to scientists and students interested in the debate on animal ethics, while also offering an important resource for future researchers. 13 is available open access under a CC BY 4.0 license at link.springer.com.

Contents: 1. Introduction to Animal Neuroethics: What and Why? -- Part I. Neuroscience of Nonhuman Minds -- 2. Sentience and Consciousness as Bases for Attributing Interests and Moral Status: Considering the Evidence—and Speculating Slightly Beyond -- 3. The Human Challenge in Understanding Animal Cognition -- 4. Mental Capacities of Fishes -- 5. Bovine Prospection, the Mesocorticolimbic Pathways, and Neuroethics: Is a Cow’s Future Like Ours? -- 6. Speciesism and Human Supremacy in Animal Neuroscience -- Part II. Neuroethical Issues and Nonhuman Animals -- 7. On Mitigating the Cruelty of Natural Selection Through Humane Genome Editing -- 8. In Defense of Neural Disenhancement to Promote Animal Welfare -- 9. The Four Cs of Modern (Neuro)ethology and Neuroethics: Cognition, Complexity, Conation and Culture -- 10. Large Brains in Small Tanks: Intelligence and Social Complexity as an Ethical Issue for Captive Dolphins and Whales -- 11. Animal Rights and Captivity in a Non-Ideal World -- 12. Nonhuman, All Too Human: Towards Developing Policies for Ethical Chimera Research -- 13. The Role of Neuroscience in Precise, Precautionary, and Probabilistic Accounts of Sentience -- Part III. Neuroethics and Nonhuman Animal Research Ethics -- 14. A Threshold Standard for Regulating Invasive Nonhuman Primate Research in the Age of the Major Brain Projects -- 15. The Right to Bodily Sovereignty and Its Importance to Mental and Physical Well-Being -- 16. The Trouble with Animal Models in Brain Research -- 17. Animal Models and the Search for Drug Treatments for Traumatic Brain Injury.

Format: e-Book

Location: Online

Neurovascular Events After Subarachnoid Hemorrhage : Towards Experimental and Clinical Standardisation

https://libcat.nshealth.ca/en/permalink/provcat39052

Javier Fandino, Serge Marbacher, Ali-Reza Fathi, Carl Muroi, Emanuela Keller, editors. --Cham: Springer , c2015.

Available Online: View e-Book

Location: Online

This book contains articles presented at the 12th International Conference on Cerebral Vasospasm, held in Lucerne, Switzerland, in July 2013. The included papers represent a balanced cross-section of the enormous progress achieved in basic and clinical research on aneurysmal subarachnoid hemorrhage and its sequelae, including early neurovascular events and delayed cerebral vasospasm. The section on basic research covers a broad range of aspects, from pathophysiology and neuroprotection in early…

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Other Authors: Fandino, Javier; Marbacher, Serge; Fathi, Ali-Reza; Muroi, Carl; Keller, Emanuela

Responsibility: Javier Fandino, Serge Marbacher, Ali-Reza Fathi, Carl Muroi, Emanuela Keller, editors

Place of Publication: Cham

Publisher: Springer

Date of Publication: c2015

Physical Description: 1 online resource (xiv, 373 p. : 112 illus., 61 illus. in color)

Series Vol.: 120

Series Title: Acta neurochirurgica. Supplement

ISBN: 9783319049816; 9783319049809 (print ed.)

ISSN: 0065-1419

Subjects (MeSH): Aneurysm - physiopathology; Cerebrovascular Disorders - physiopathology; Models, Animal; Subarachnoid Hemorrhage - complications

Abstract: This book contains articles presented at the 12th International Conference on Cerebral Vasospasm, held in Lucerne, Switzerland, in July 2013. The included papers represent a balanced cross-section of the enormous progress achieved in basic and clinical research on aneurysmal subarachnoid hemorrhage and its sequelae, including early neurovascular events and delayed cerebral vasospasm. The section on basic research covers a broad range of aspects, from pathophysiology and neuroprotection in early brain injury through to macro- and microcirculatory disturbances, inflammation and blood-brain barrier disruption, spreading depolarization, and the role of nitric oxide. There is a special focus on animal models for the study of acute events after experimental subarachnoid hemorrhage. The section on clinical topics encompasses imaging and endovascular management, surgical innovations and techniques, management and monitoring in neurocritical care, the status of clinical trials, and factors involved in aneurysm formation. This edition is of interest not only for basic researchers but also for clinicians who wish to apply state-of-the-art knowledge to the research and management of this devastating condition.

Contents: Basic Research Topics: Early Brain Injury: Pathophysiology -- Early Brain Injury: Neuroprotection -- Macro- and Microcirculatory Disturbance -- Inflammation and Blood-Brain-Barrier Disruption -- Spreading Depolarization: From Bench to Bedside and Back -- Nitric Oxide: From Bench to Bedside. Clinical Topics: Imaging and Endovascular Management -- Treatment: Surgical Innovations and Techniques -- Neurocritical Care: Management -- Neurocritical Care: Monitoring -- Clinical Trials: Current Status and the Way forward -- Aneurysm Formation: Morphology, Environment, and Genetics.

Format: e-Book

Location: Online

Osteoporosis Research : Animal Models

https://libcat.nshealth.ca/en/permalink/provcat28341

edited by Gustavo Duque, Ken Watanabe. --London: Springer-Verlag , c2011.

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Location: Online

Available Online: View e-Book

Author: Duque, Gustavo

Other Authors: Watanabe, Ken

Responsibility: edited by Gustavo Duque, Ken Watanabe

Place of Publication: London

Publisher: Springer-Verlag

Date of Publication: c2011

ISBN: 9780857292933

Subjects (MeSH): Osteoporosis - physiology; Disease Models, Animal; Bone and Bones - physiology

Subjects (LCSH): Orthopedics

Format: e-Book

Location: Online

Patient-Derived Mouse Models of Cancer : Patient-Derived Orthotopic Xenografts (PDOX)

https://libcat.nshealth.ca/en/permalink/provcat41821

Robert M. Hoffman, editor. --Cham: Humana Press , 2017.

Available Online: View e-Book

Location: Online

This text highlights seminal discoveries and also provides comprehensive and state-of the-art approach to mouse models of human patient tumors. These areas include training, basic techniques, as well as general troubleshooting. Subsequent chapters focus on the different mouse models of patient tumors including the various strains of immunodeficient mice currently available and the transplantation techniques that can be used as well as state-of-the-art imaging techniques. Practical applications …

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Other Authors: Hoffman, Robert M

Responsibility: Robert M. Hoffman, editor

Place of Publication: Cham

Publisher: Humana Press

Date of Publication: 2017

Physical Description: 1 online resource (xvi, 296 pages) : 60 illus., 50 illus. in color

Series Title: Molecular and translational medicine

ISBN: 9783319574240; 9783319574233 (print ed.)

ISSN: 2197-7852

Subjects (MeSH): Disease Models, Animal; Heterografts; Neoplasms - pathology; Xenograft Model Antitumor Assays

Abstract: This text highlights seminal discoveries and also provides comprehensive and state-of the-art approach to mouse models of human patient tumors. These areas include training, basic techniques, as well as general troubleshooting. Subsequent chapters focus on the different mouse models of patient tumors including the various strains of immunodeficient mice currently available and the transplantation techniques that can be used as well as state-of-the-art imaging techniques. Practical applications of the models from drug discovery, genome analysis to personalized treatment are also covered. Written by experts in that field, each of these sections address these critical issues. A brief review of the existing literature addressing the particular topic follows in each section. Presently, there is no single source to provide information on technique and uses of mouse models of human patient tumors. Patient-Derived Mouse Models of Cancer will satisfy this need for cancer researchers, oncologists, pharmaceutical and biotechnology industry scientists as well as molecular biologists studying in vivo systems.

Contents: In memorium: Jorgen Rygaard (1934-2016) Father of patient derived mouse models of cancer and modern cancer research -- The revival of patient-derived mouse models of cancer: way back to the future -- Patient-derived xenograft models for human cancer, The Freiburg experience -- From Ectopic to Orthotopic Tumor Grafting Sites: Evidence for a Critical Role of the Host Tissue Microenvironment for the Actual Expression of the Malignant Phenotype -- The Effects of the Organ Microenvironment on Metastatic-Cell Gene Signatures -- Techniques for surgical orthotopic implantation of human tumors to immunodeficient mice -- The first patient-derived orthotopic xenograft (PDOX) mouse models of cancer: Cancer of the colon, pancreas, lung, breast, ovary, and mesothelioma -- Patient-derived xenograft models of prostate cancer -- Patient-Derived Mouse Models of Sarcoma -- Cervical cancer patient-derived orthotopic xenograft (PDOX) models -- The use of pediatric patient-derived xenografts for identifying novel agents and combinations -- Development of Orthotopic and Spontaneous Metastatic Human Tumor Xenograft Models for Experimental Therapeutics -- Use of patient-derived orthotopic xenografts (PDOX) to evaluate transformative cancer therapeutics -- Fluorescent protein-expressing transgenic nude mice as hosts for patient tumors -- Fluorescence imaging of tumors in human patient-derived orthotopic xenograft (PDOX) mouse models: The iPDOX model -- The use of patient-derived orthotopic xenograft (PDOX) models to develop curative fluorescence-guided surgery of cancer -- Molecular characteristics of patient-derived tumor xenografts: genomic similarity to patient tumors and relevance for biomarker discovery -- Complementarity of patient-derived orthotopic xenografts (PDOX) models and molecular profiling for optimal therapy -- 3D Cell Culture Models -- Why patient derived mouse models need to be orthotopic -- Foreward: The future of patient-derived models of cancer.

Format: e-Book

Location: Online

Patient-Derived Xenograft Models of Human Cancer

https://libcat.nshealth.ca/en/permalink/provcat41779

Yuzhuo Wang, Dong Lin, Peter W. Gout, editors. --Cham: Humana Press , 2017.

Available Online: View e-Book

Location: Online

This book provides a comprehensive, state-of-the-art review of PDX cancer models. In separately produced chapters, the history and evolution of PDX models is reviewed, methods of PDX model development are compared in detail, characteristics of available established models are presented, current applications are summarized and new perspectives about use of PDX models are proposed. Each chapter is written by a world-renowned expert who is conducting cutting-edge research in the field. Each of the…

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Other Authors: Wang, Yuzhuo; Lin, Dong; Gout, Peter W

Responsibility: Yuzhuo Wang, Dong Lin, Peter W. Gout, editors

Place of Publication: Cham

Publisher: Humana Press

Date of Publication: 2017

Physical Description: 1 online resource (xi, 204 pages) : 27 illus., 26 illus. in color

Series Title: Molecular and translational medicine

ISBN: 9783319558257; 9783319558240 (print ed.)

ISSN: 2197-7852

Subjects (MeSH): Disease Models, Animal; Heterografts; Neoplasms - pathology; Xenograft Model Antitumor Assays

Abstract: This book provides a comprehensive, state-of-the-art review of PDX cancer models. In separately produced chapters, the history and evolution of PDX models is reviewed, methods of PDX model development are compared in detail, characteristics of available established models are presented, current applications are summarized and new perspectives about use of PDX models are proposed. Each chapter is written by a world-renowned expert who is conducting cutting-edge research in the field. Each of the subsections provide a comprehensive review of existing literature addressing the particular topic followed by a conclusive paragraph detailing future directions. Extensive illustrations make this an interactive text. Patient-Derived Xenograft Models of Human Cancer will serve as a highly useful resource for researchers and clinicians dealing with, or interested in, this important topic. It will provide a concise yet comprehensive summary of the current status of the field that will help guide preclinical and clinical applications as well as stimulate investigative efforts. This book will propagate innovative concepts and prompt the development of ground-breaking technological solutions in this field.

Contents: 1. Patient-Derived Tumor Xenografts: Historical Background -- 2. Towards Best Practice in Establishing Patient-Derived Xenografts -- 3. Fidelity and Stability of PDX Models -- 4. Humanized Mouse and Rat PDX Cancer Models -- 5. Studies of Cancer Heterogeneity Using PDX Models -- 6. The Plasticity of Stem-Like States in Patient-Derived Tumor Xenografts -- 7. Modeling Cancer Metastasis -- 8. Modeling Drug Resistance in PDX Models -- 9. Using PDX for Biomarker Development -- 10. Patient-Derived Xenografts as Cancer Models for Preclinical Drug Screening -- 11. First-Generation Tumor Xenografts: A Link Between Patient-Derived Xenograft Models and Clinical Disease -- 12. Application of PDX Cancer Models in Co-clinical Trials and Personalized/Precision Medicine -- 13. Prospectives.

Format: e-Book

Location: Online

Plastic and Reconstructive Surgery : Experimental Models and Research Designs

https://libcat.nshealth.ca/en/permalink/provcat38892

Maria Z. Siemionow, editor. --London: Springer , c2015.

Available Online: View e-Book

Holdings: Halifax Infirmary: v. 83, 1989 - v. 96, 1995.

Location: Online

With novel approaches to the application of new technologies via research based studies on stem cells, tissue engineering and new fields of reconstructive transplant (face, hand or larynx transplants), this book facilitates access to this latest knowledge which is not traditionally part of the plastic surgery curriculum. Plastic and Reconstructive Surgery: Experimental Models and Research Designs presents pertinent introductions to different fields (stem cell, transplantation, nerve regeneratio…

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Other Authors: Siemionow, Maria Z

Responsibility: Maria Z. Siemionow, editor

Place of Publication: London

Publisher: Springer

Date of Publication: c2015

Holdings: Halifax Infirmary: v. 83, 1989 - v. 96, 1995.

Physical Description: 1 online resource (xviii, 661 p. : 50 illus., 25 illus. in color)

ISBN: 9781447163350; 9781447163343 (print ed.)

ISSN: 0032-1052

Subjects (MeSH): Models, Animal; Reconstructive Surgical Procedures; Surgery, Plastic - methods; Transplantation - methods

Abstract: With novel approaches to the application of new technologies via research based studies on stem cells, tissue engineering and new fields of reconstructive transplant (face, hand or larynx transplants), this book facilitates access to this latest knowledge which is not traditionally part of the plastic surgery curriculum. Plastic and Reconstructive Surgery: Experimental Models and Research Designs presents pertinent introductions to different fields (stem cell, transplantation, nerve regeneration, tissue engineering) and experimental models which can be used as a tool to develop technologies of interest by various groups of surgeons. Plastic and Reconstructive Surgery: Experimental Models and Research Designs benefits a range of surgeons, including plastic and reconstructive surgeons, microsurgeons, hand surgeons, orthopedic surgeons, neurosurgeons and transplant surgeons.

Contents: Part 1. Microsurgery Models -- 1. Microsurgery Techniques in Reconstructive Surgery -- 2. Arterial and Venous Microanastomosis Models -- 3. Lymphaticovenous Anastomosis Training Model in Rat -- 4. Fallopian Tube Anastomosis -- 5. Vasoepididymostomy Anastomosis -- 6. The Microsurgical Groin Slin Flap in the Rat Model -- 7. Free TRAM Flap Model -- Part 2. Microcirculation Models -- 8. Application of Microcirculatory Models in Plastic Surgery Research -- 9. Standard Cremaster Muscle Model for Ischemia Reperfusion -- 10. Cremaster Muscle and Effect of Different Anesthetics -- 11. Microcirculatory Shock Model -- 12. Radiation and Microcirculation Models -- 13. Microcirculation and Smoking -- 14. Microcirculation Model for Invasive Animal Monitoring -- 15. Cremaster Chamber Model -- 16. Mouse Cremaster Muscle Allograft Model -- 17. Microcirculation and Pace Therapy -- 18. Microcirculation and Hypothermia Model -- Part 3. Transplantation Models -- 19. Vascularized Composite Allotransplantation Models -- 20. Rat Hind Cremaster Limb Allograft Model -- 21. Limb and Microcirculation - Cremaster Flap Model -- 22. Bilateral Vascularized Composite Skin/Bone Transplantation Model -- 23. Vascular Thymus and Hind Limb Allotransplantation Model -- 24. Vascular Thymus Transplantation -- 25. Vascularized Skin/Bone Transplantation Model -- 26. Vascularized Bone-Femur Transplantation Model -- 27. New Composite Tissue Allograft Model of Vascularized Bone Marrow Transplant: The Iliac Osteomyocutaneous Flap -- 28. New Modification of the Oldest Flap in Rats to Increase Antigenixcity of Transplanted Skin: The Extended Groin Flap Model -- 29. Combined Semimenbranosus Muscle and Epigastric Skin Flap Model -- 30. Composite Osseomusculocutaneous Thymus, Allotransplantation Model -- 31. Experimental Model for Monitoring of Composite Tissue Transplantation Induced Trauma -- 32. Cryopreservation in Plastic Surgery: Our Experience and Review of the Literature -- 33. A Xenotransplantation Model for Vascularized Composite Transplantation -- 34. Full Face Transplant Model in Rats -- 35. Hemiface Transplant Model -- 36. Composite Hemiface/Calvarium Transplantation Model in Rat -- 37. Maxilla Allograft Transplantation Model in Rat -- 38. Composite Hemiface/Mandible/Tongue Allotransplantation Model in Rats -- 39. Composite Osseomusculocutaneous Midface Allotransplantation Model with Motor and Sensory Units -- 40. Transplantation of the Mystacial Pad -- 41. Heterotopic Transplantation of Total Face/Scalp Flap -- 42. Non-Invasive Monitoring of Skin-Containing Vascularized Composite Allotransplantation -- 43. Abdominal Wall Transplant Models -- 44. Penis Allotransplantation Model -- 45. Composite Orbital and Periorbital Allotransplantation Model -- 46. Ear Transplantation -- 47. Heterotopic Vascularized Ovarian Autotransplantation Model in the Sheep -- 48. Spleen Transplantation Model -- Part 4. Peripheral Nerve Surgery Models -- 49. A Contemporary Overview of Peripheral Nerve Research -- 50. Epineural Sleeve End-to-End Repair -- 51. Somatosensory Evoked Potential Model for Assessment of Nerve Regeneration -- 52. Epineural Sleeve Nerve Grafting Technique -- 53. Single Fascicle Graft Repair Mofel -- 54. Nerve Decompression Models in Diabetic Rats -- 55. Epineural Seath Grafts for Nerve Regeneration -- 56. Epineural Tube Repair -- 57. Tissue Engineered Conduit -- 58. Venous Conduit as a Model for Nerve Regeneration -- 59. DRG Decompression Model -- 60. Epineural Patch Applications in Dorsal Root Ganglion Decompression Model -- 61. Sheep as a Large Animal Model for Nerve Regeneration Studies -- 62. Sciatic Nerve Crush Injury Model -- 63. Crush Injury and Epineural Patch Model -- 64. Neuroma Model -- 65. Diabetic Rat Model -- 66. Nerve Allograft Transplantation Review -- 67. Nerve Allograft Transplantation Review -- Part 5. Microsurgical Robot Applications -- 68. Application of the Microsurgical Robot RAMS in Microsurgery -- Part 6. Cellular Therapy Models -- 69. Cellular Therapies in Vascularized Composite Allograft Transplantation: Review -- 70. In Vivo Chimera Model by Chimera Creation -- 71. Ex Vivo Chimera Model by Cell Fusion -- 72. Cellular Therapies via Vascularized Bone Marrow Transplantation -- 73. Cellular Therapies in Vascularized Composite Allograft -- 74. Cellular Therapies in Post-Radiation Syndrome -- 75. Cellular Therapies in Nerve Regeneration.