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Biomarkers in breast cancer : molecular diagnostics for predicting and monitoring therapeutic effect

https://libcat.nshealth.ca/en/permalink/provcat22482
Gasparini, Giampietro. --Totowa, NJ: Humana Press , 2006.
Call Number
WP 870 B615 2006
Location
Dickson Building
Call Number
WP 870 B615 2006
Author
Gasparini, Giampietro
Other Authors
Hayes, Daniel F
Place of Publication
Totowa, NJ
Publisher
Humana Press
Date of Publication
2006
Physical Description
341 p.
Series Title
Cancer drug discovery and development
ISBN
1588292274
Subjects (MeSH)
Breast Neoplasms - diagnosis
Molecular Diagnostic Techniques
Tumor Markers, Biological
Format
Book
Location
Dickson Building
Loan Period
3 weeks
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Circulating Nucleic Acids in Early Diagnosis, Prognosis and Treatment Monitoring : An Introduction

https://libcat.nshealth.ca/en/permalink/provcat39543
Peter B. Gahan, editor. --Dordrecht: Springer Netherlands , c2015.
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Location
Online
DNA and RNA fractions can be isolated from a variety of body fluids including whole blood, serum, plasma, urine, saliva and cerebrospinal fluid from both patients and healthy individuals. Such isolates can be exploited in the early detection of clinical disorders, stratification of patients for treatment, treatment monitoring and clinical follow-up. In addition, the use in fetal medicine allows the early detection of fetal sex, Rh factor and aneuploid disorders as well as following both fetal a…
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Other Authors
Gahan, Peter B
Responsibility
Peter B. Gahan, editor
Place of Publication
Dordrecht
Publisher
Springer Netherlands
Date of Publication
c2015
Physical Description
1 online resource (xix, 471 p. : 59 illus., 39 illus. in color)
Series Vol.
v. 5
Series Title
Advances in predictive, preventive and personalised medicine
ISBN
9789401791687
9789401791670 (print ed.)
ISSN
2211-3495
Subjects (MeSH)
Genetic testing
Genomics
Molecular Diagnostic Techniques
Nucleic Acids - analysis
Nucleic Acids - isolation & purification
Abstract
DNA and RNA fractions can be isolated from a variety of body fluids including whole blood, serum, plasma, urine, saliva and cerebrospinal fluid from both patients and healthy individuals. Such isolates can be exploited in the early detection of clinical disorders, stratification of patients for treatment, treatment monitoring and clinical follow-up. In addition, the use in fetal medicine allows the early detection of fetal sex, Rh factor and aneuploid disorders as well as following both fetal and premature born infant development. This volume is intended as a primer for those who are interested in entering the field of circulating nucleic acids. The areas covered in this volume include: Background and general biology of circulating nucleic acids; Methodology; Applications of circulating nucleic acids; Quality Assurance; Ethics.
Contents
Part I. BACKGROUND -- 1. Introduction: Brief History and the present and future status of CNAPS -- 2. The biology of CNAPS -- Part II. METHODOLOGY -- 3. Pre-analytical requirements for analysing nucleic acids from blood -- 4. Circulating DNA and miRNA isolation -- 5. Detection of genetic alterations by nucleic acid analysis: use of pcr and mass spectroscopy-based methods -- 6. Genomic approaches to the analysis of cell free nucleic acids -- Part III APPLICATIONS -- 7. CNAPS and General Medicine -- 8. Fetal CNAPS: DNA/RNA -- 9. Circulating nucleic acids and Diabetes mellitus -- 10. Extracellular nucleic acids and cancer -- 11. Other bodily fluids as non-invasive sources of Cell-free DNA/RNA -- 12. CNAPS in therapy monitoring -- Part IV OTHER ASPECTCS -- 13. Quality Assurance -- 14. Societal Aspects: Ethics.
Format
e-Book
Location
Online
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Diagnostic Molecular Pathology in Practice : A Case-Based Approach

https://libcat.nshealth.ca/en/permalink/provcat30466
edited by Iris Schrijver. --Berlin, Heidelberg: Springer-Verlag , c2011.
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Location
Online
Available Online
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Author
Schrijver, Iris
Responsibility
edited by Iris Schrijver
Place of Publication
Berlin, Heidelberg
Publisher
Springer-Verlag
Date of Publication
c2011
ISBN
9783642196775
Subjects (MeSH)
Molecular Diagnostic Techniques - Case Reports
Pathology - methods - Case Reports
Subjects (LCSH)
Pathology
Format
e-Book
Location
Online
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Fundamentals of molecular diagnostics

https://libcat.nshealth.ca/en/permalink/provcat11221
[edited by] David E. Burns, Edward R. Ashwood, and Carl A. Burtis ; consulting editor, Barbara G. Sawyer. --St. Louis, MO: Saunders Elsevier , c2007.
Call Number
QY 25 F981 2007
Location
Cape Breton Regional
Call Number
QY 25 F981 2007
Other Authors
Bruns, David E, 1941-
Ashwood, Edward R., 1953-
Burtis, Carl A.
Responsibility
[edited by] David E. Burns, Edward R. Ashwood, and Carl A. Burtis ; consulting editor, Barbara G. Sawyer
Place of Publication
St. Louis, MO
Publisher
Saunders Elsevier
Date of Publication
c2007
Physical Description
xvii, 267 p. : ill.
ISBN
9781416037378
1416037373
Subjects (MeSH)
Molecular Diagnostic Techniques
Format
Book
Location
Cape Breton Regional
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Genetic diagnosis of endocrine disorders

https://libcat.nshealth.ca/en/permalink/provcat50736
Weiss, Roy. (2nd ed.) --Philadelphia, PA: Elsevier , 2016.
Available Online
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Location
Online
Available Online
View e-Book
Author
Weiss, Roy
Edition
2nd ed.
Place of Publication
Philadelphia, PA
Publisher
Elsevier
Date of Publication
2016
ISBN
9780128008928
Subjects (MeSH)
Endocrine System Diseases - diagnosis
Endocrine System Diseases - genetics
Genetic Testing
Molecular Diagnostic Techniques
Notes
Access to this online resource is restricted to IWK Health Centre employees working from inside the hospital network.
Format
e-Book
Location
Online
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Genetic diagnosis of endocrine disorders

https://libcat.nshealth.ca/en/permalink/provcat31539
edited by Roy E. Weiss, Samuel Refetoff. (2nd ed.) --Amsterdam, Netherlands: Elsevier , c2016.
Available Online
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Access
Registration required for PDF access.
Location
Online
Available Online
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Other Authors
Weiss, Roy E
Refetoff, Samuel
Responsibility
edited by Roy E. Weiss, Samuel Refetoff
Edition
2nd ed.
Place of Publication
Amsterdam, Netherlands
Publisher
Elsevier
Date of Publication
c2016
Physical Description
1 online resource, 444 p.
ISBN
9780128008928
Subjects (MeSH)
Endocrine System Diseases - diagnosis
Endocrine System Diseases - genetics
Genetic testing
Molecular Diagnostic Techniques
Subjects (LCSH)
Endocrine glands - Diseases - Genetic aspects
Endocrine glands - Diseases - Diagnosis
Endocrine glands - Diseases - Treatment
Genetic Testing
Access
Registration required for PDF access.
Format
e-Book
Location
Online
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Genomic Medicine : A Practical Guide

https://libcat.nshealth.ca/en/permalink/provcat44958
Laura J. Tafe, Maria E. Arcila, editors. --Cham: Springer , c2020.
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Location
Online
The field of Molecular Diagnostics is rapidly evolving and molecular characterization of neoplasms is becoming an increasingly important part of the pathologic work up and diagnosis of many tumor types. This work provides a high-yield reference book that compiles critical information related to molecular biomarkers for various solid tumor and hematologic malignancy subtypes. It is succinct yet comprehensive enough to be suitable for fellows in training and medical professionals with an interest…
Available Online
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Other Authors
Tafe, Laura J.
Arcila, Maria E.
Responsibility
Laura J. Tafe, Maria E. Arcila, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2020
Physical Description
1 online resource (x, 325 p.) : 21 illus., 20 illus. in color
ISBN
9783030229221
9783030229214 (Print ed.)
9783030229238 (Print ed.)
Subjects (MeSH)
Biomarkers, Tumor
Molecular Diagnostic Techniques
Pathology, Molecular
Precision Medicine - methods
Specialty
Genetics, Medical
Abstract
The field of Molecular Diagnostics is rapidly evolving and molecular characterization of neoplasms is becoming an increasingly important part of the pathologic work up and diagnosis of many tumor types. This work provides a high-yield reference book that compiles critical information related to molecular biomarkers for various solid tumor and hematologic malignancy subtypes. It is succinct yet comprehensive enough to be suitable for fellows in training and medical professionals with an interest in molecular pathology and biomarkers. The book covers many aspects of molecular diagnostics, from techniques to applications and comprehensive summaries of the current molecular biomarkers of critical importance in solid and liquid tumors. Attention is also specifi cally devoted to bioinformatics and next generation sequencing, as well as pre-analytical issues that must be considered for accurate interpretation of molecular results in the context of overall patient care. This text focuses on clinical utility and validity and serves as an “owner’s manual” in Genomic Diagnostics for the practicing pathologist, pathology fellows and residents and other health care providers. Physicians will find this book invaluable as a quick reference for current molecular testing modalities and guidelines, tumor board preparation, deciding which test to order and interpreting genomic laboratory results. In addition, it is an accessible for trainees as a board review preparation reference.
Contents
Part I. General Concepts -- Pre-Analytics, Current Testing Technologies, and Limitations of Testing -- Next Generation Sequencing -- Cell-Free DNA Testing -- Role of Bioinformatics in Molecular Medicine -- Interpreting Genomic Reports -- Part II. Applications in Solid Tumors -- Lung Carcinoma -- GI including GIST -- Breast -- Genitourinary Tumors -- Gynecologic Malignancies -- Sarcomas -- Salivary Gland Carcinomas -- Sinonasal Carcinomas -- Part III. Applications in Hematopathology -- Acute Myeloid Neoplasms -- Chronic Myeloid Neoplasms -- Lymphomas.
Format
e-Book
Location
Online
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Gestational Trophoblastic Disease : Diagnostic and Molecular Genetic Pathology

https://libcat.nshealth.ca/en/permalink/provcat31010
Pei Hui, editor. --New York, NY: Springer , c2012.
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Location
Online
In this volume Dr Hui has brought together a comprehensive overview of gestational trophoblastic disease that includes all the currently recognized entities: complete and partial hydatidiform moles, placental site trophoblastic tumor, epithelioid trophoblastic tumor, gestational choriocarcinoma, persistent gestational trophoblastic neoplasia, placental site nodule and exaggerated placental site reaction. Each entity is reviewed in detail, with emphasis on genetic background, clinical presentati…
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Other Authors
Hui, Pei
Responsibility
Pei Hui, editor
Place of Publication
New York, NY
Publisher
Springer
Date of Publication
c2012
Physical Description
1 online resource (xiii, 205 p. : 104 ill., 96 ill. in color)
Series Title
Current clinical pathology
ISBN
9781617793943
Subjects (MeSH)
Gestational Trophoblastic Disease - pathology
Molecular Diagnostic Techniques
Pathology, Molecular - methods
Subjects (LCSH)
Pathology
Gynecology
Oncology
Abstract
In this volume Dr Hui has brought together a comprehensive overview of gestational trophoblastic disease that includes all the currently recognized entities: complete and partial hydatidiform moles, placental site trophoblastic tumor, epithelioid trophoblastic tumor, gestational choriocarcinoma, persistent gestational trophoblastic neoplasia, placental site nodule and exaggerated placental site reaction. Each entity is reviewed in detail, with emphasis on genetic background, clinical presentation, pathologic findings and ancillary studies, differential diagnosis and clinicopathological correlations. Descriptions of the pathology are supported by numerous excellent photomicrographs. Recent advances in our understanding of the genetics of gestational trophoblastic diseases are stressed. Introductory chapters cover the developmental biology of the placenta and the genetic basis of gestational trophoblastic disease, and one chapter is devoted to the molecular diagnosis of gestational trophoblastic disease. This chapter includes a review of the use of short tandem repeat (STR) genotyping which is of particular value in the diagnosis of hydatidiform moles. The final chapter covers clinical aspects of gestational trophoblastic disease, including treatment. The text throughout is current and thoroughly referenced. This book will be of great value to pathologists, community gynecologists, gynecological pathologists and medical students.
Contents
Gestational trophoblastic disease: general aspects -- Developmental biology of the placenta -- Genetic basis of gestational trophoblastic disease -- Complete hydatidiform mole -- Partial hydatidiform mole -- Placental site trophoblastic tumor -- Epithelioid trophoblastic tumor -- Gestational choriocarcinoma -- Persistent trophoblastic neoplasia -- Tumor-like trophoblastic conditions -- Molecular diagnosis of gestational trophoblastic disease -- Clinical aspects of gestational trophoblastic disease.
Format
e-Book
Location
Online
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Guidelines for Molecular Analysis in Archive Tissues

https://libcat.nshealth.ca/en/permalink/provcat30136
edited by Giorgio Stanta. --Berlin, Heidelberg: Springer-Verlag , c2011.
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Location
Online
Available Online
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Author
Stanta, Giorgio
Responsibility
edited by Giorgio Stanta
Place of Publication
Berlin, Heidelberg
Publisher
Springer-Verlag
Date of Publication
c2011
ISBN
9783642178900
Subjects (MeSH)
Molecular Diagnostic Techniques
Sequence Analysis
Tissue Extracts
Tissue Fixation
Subjects (LCSH)
Medical laboratories
Pathology
Format
e-Book
Location
Online
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Hematopathology : Genomic Mechanisms of Neoplastic Diseases

https://libcat.nshealth.ca/en/permalink/provcat29796
Domnita Crisan, editor. --New York: Humana Press , c2010.
Available Online
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Location
Online
Hematopathology: Genomic Mechanisms of Neoplastic Diseases will keep physicians abreast of the rapid and complex changes in genomic medicine, as exemplified by the molecular pathology of hematologic malignancies. This timely volume will update physicians on the complexities of genomic lesions, as well as offer an integrated framework encompassing molecular diagnosis, the new WHO classification of hematologic neoplasms with focus on molecular pathology, prognostic value of molecular tests, and m…
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Author
Crisan, Domnita
Responsibility
Domnita Crisan, editor
Place of Publication
New York
Publisher
Humana Press
Date of Publication
c2010
Physical Description
1 online resource (xii, 358 p. . ill.)
Series Title
Molecular and translational medicine
ISBN
9781607612629
9781607612612 (print ed.)
Subjects (MeSH)
Hematologic Neoplasms - genetics
Hematologic Neoplasms - pathology
Lymphoproliferative Disorders - genetics
Lymphoproliferative Disorders - pathology
Molecular Diagnostic Techniques
Subjects (LCSH)
Hematology
Oncology
Genetics
Abstract
Hematopathology: Genomic Mechanisms of Neoplastic Diseases will keep physicians abreast of the rapid and complex changes in genomic medicine, as exemplified by the molecular pathology of hematologic malignancies. This timely volume will update physicians on the complexities of genomic lesions, as well as offer an integrated framework encompassing molecular diagnosis, the new WHO classification of hematologic neoplasms with focus on molecular pathology, prognostic value of molecular tests, and molecular monitoring of response to gene-targeted therapy. As such, it will be of great value to hematologists, oncologists, pathologists, internal medicine and pediatric specialists, as well as bioscientific staff and laboratorians in private hospitals and academic institutions.
Contents
1. Molecular techniques used in hematopathology -- 2. Cytogenetics techniques used in hematopathology -- 3. The molecular component of the new WHO classification of hematologic malignancies -- 4. Molecular pathology of pediatric acute leukemias -- 5. Molecular pathology of adult acute leukemias -- 6. Molecular pathology of lymphomas -- 7. Molecular pathology of chronic myeloproliferative neoplasms -- 8. Molecular pathology of CLL -- 9. Targeted therapy in hematologic malignancies -- 10. MicroRNAs in hematologic malignancies.
Format
e-Book
Location
Online
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Modern Clinical Molecular Techniques

https://libcat.nshealth.ca/en/permalink/provcat30958
Peter Hu, Madhuri Hegde, Patrick Alan Lennon, editors. --New York, NY: Springer , c2012.
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Location
Online
This timely book covers the need to know clinical practices for all those involved in molecular laboratory science. The field of molecular medicine is evolving at an astounding speed. Propelled by the new insights and technologies, advances are being made at an unprecedented rate. With dual measure given to today's breakthroughs, this book is a collection of the most current practices relevant to the clinical molecular laboratorian. It begins with an introductory section on techniques and proce…
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Other Authors
Hu, Peter
Hegde, Madhuri
Lennon, Patrick Alan
Responsibility
Peter Hu, Madhuri Hegde, Patrick Alan Lennon, editors
Place of Publication
New York, NY
Publisher
Springer
Date of Publication
c2012
Physical Description
1 online resource (xiii, 436 p. : 60 ill., 41 ill. in color)
ISBN
9781461421702
Subjects (MeSH)
Molecular Diagnostic Techniques
Subjects (LCSH)
Pathology
Medical laboratories
Abstract
This timely book covers the need to know clinical practices for all those involved in molecular laboratory science. The field of molecular medicine is evolving at an astounding speed. Propelled by the new insights and technologies, advances are being made at an unprecedented rate. With dual measure given to today's breakthroughs, this book is a collection of the most current practices relevant to the clinical molecular laboratorian. It begins with an introductory section on techniques and procedure. It then presents four separate sections on infectious disease, oncology, pre/post-natal, and identity testing, with specific chapters clearly outlining clinical protocols used in daily practice. Modern Clinical Molecular Techniques cuts to the heart of what is essential for the practicing molecular laboratory scientist. It is an outstanding resource for those operating within or looking to set up a clinical molecular laboratory.
Contents
Specimen Collection, Handling and Processing -- DNA/RNA Isolation and Quantitation -- Test Validation -- In Vitro Amplification Methods in Molecular Diagnostics -- Whole Genome Sequencing in the Clinical Laboratory -- Estimation of Exon Dosage Using Real-Time Quantitative Polymerase Chain Reaction: Applications to Factor VIII Gene in Hemophilia A and Endoglin/ACVRL1 Genes in Hereditary Hemorrhagic Telangiectasia -- Reporting Clinical Molecular Genetic Laboratory Results -- HIV-1 Genotyping and Virtual Phenotyping -- COBAS® AmpliPrep/COBAS® TaqMan® HIV-1 Test, Version 2.0 -- Hepatitis C Virus (HCV) Genotype Assay (LiPA) -- COBAS® AmpliPrep/COBAS® TaqMan® HCV Test -- Epstein-Barr Virus and Cytomegalovirus Viral Load Monitoring by Quantitative Real-Time Polymerase Chain Reaction -- Quantification of BK Viral Load -- Molecular Diagnosis and Epidemiology of Rabies -- Pyrosequencing for Bacterial Identification -- Other Pathogens of Significant Public Health Concern -- Gene Rearrangements Testing -- Mutation Analysis in Cancer -- Minimal Residual Disease -- Pyrosequencing in Cancer -- Clinical Applications of Microarrays in Cancer -- Basic Theories and Clinical Applications of Molecular Flow Cytometry -- Molecular Prenatal Diagnostic Testing -- PCR Based Diagnosis of Fragile X Syndrome -- Microsatellite Testing Short Tandem Repeat Profile Generation -- Parentage -- Diagnostic Molecular Training -- Molecular Diagnostics Point of Care Testing Training.
Format
e-Book
Location
Online
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Molecular Allergy Diagnostics : Innovation for a Better Patient Management

https://libcat.nshealth.ca/en/permalink/provcat41424
Jörg Kleine-Tebbe, Thilo Jakob, editors. --Cham: Springer , 2017.
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Location
Online
This book, based on a recent German publication, offers an overview of basic data and recent developments in the groundbreaking field of molecular allergology. It comprehensively explores the origin and structure of single allergen molecules ("components") and their utility in improving the management of type I, IgE-mediated allergic reactions and disorders like allergic respiratory diseases, food allergies, and anaphylaxis. Highly specific testing, called component-resolved diagnostics, aims t…
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Other Authors
Kleine-Tebbe, Jörg
Jakob, Thilo
Responsibility
Jörg Kleine-Tebbe, Thilo Jakob, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
2017
Physical Description
1 online resource (xx, 531 pages) : 112 illus., 100 illus. in color
ISBN
9783319424996
9783319424989 (print ed.)
Subjects (MeSH)
Allergens - immunology
Biomarkers - analysis
Hypersensitivity - diagnosis
Immunoglobulin E - immunology
Molecular Diagnostic Techniques
Sensitivity and Specificity
Abstract
This book, based on a recent German publication, offers an overview of basic data and recent developments in the groundbreaking field of molecular allergology. It comprehensively explores the origin and structure of single allergen molecules ("components") and their utility in improving the management of type I, IgE-mediated allergic reactions and disorders like allergic respiratory diseases, food allergies, and anaphylaxis. Highly specific testing, called component-resolved diagnostics, aims to identify and utilize single molecules. Over 200 single allergens from plant or animal sources have been applied to single or multiplex laboratory testing for the presence of allergen-specific IgE. This leap in assay sensitivity and specificity has led to three major advances in patient management: discrimination between primary allergic sensitization and complex cross-reactivity, recognition of IgE profiles for certain allergens and identification of patients most likely to benefit from allergen-specific immunotherapy. The book discusses in detail the benefits and limitations of this 21st century technology, and offers suggestions for the use of molecular allergology in routine clinical practice. It is a "must read" for physicians treating allergic patients as well as scientists interested in natural allergic molecules and their interactions with the human immune system.
Contents
Part I: Protein Families and Relationships -- 1. Introduction to Molecular Allergology: Protein Families, Databases, and Potential Benefits -- 2. Bet v 1 and its Homologs: Triggers of Tree-Pollen Allergy and Birch Pollen-Associated Cross-Reactions -- 3. The Concept of Pollen Panallergens: Profilins and Polcalcins -- 4. Stable Plant Food Allergens I: Lipid-Transfer Proteins -- 5. Stable Plant Food Allergens II: Storage Proteins -- 6. Cross-Reactive Carbohydrate Determinants: Diagnostic and Clinical Relevance -- Part II: Test Systems, Singleplex Analysis and Multiplex Analysis -- 7. Molecular Allergy Diagnostics Using IgE Singleplex Assays: Methodological and Practical Considerations -- 8. Spiking with Recombinant Individual Allergens for Improvement of Allergen Extracts -- 9. Molecular Allergy Diagnostics Using Multiplex Assays -- Part III: Marker Allergens -- 10. Marker Allergens and Panallergens in Tree and Grass Pollen Allergy -- 11. Marker Allergens of Weed Pollen: Basic Considerations and Diagnostic Benefits in Routine Clinical Practice -- 12. Molecular Diagnostics for Peanut Allergy -- 13. Molecular Diagnostics for Tree Nut Allergy -- 14. Molecular Diagnostics of Allergy to Fruits and Vegetables -- 15. Cow’s Milk and Hen’s Egg Allergy: What Do Molecular-Based Allergy Diagnostics Have to Offer? -- 16. Molecular and Extract-Based Diagnostics in Meat Allergy -- 17. Molecular Diagnostics in Food-Dependent Exercise-Induced Anaphylaxis -- 18. Benefits and Limitations of Recombinant Allergens in Diagnostics of Insect Venom Allergy -- 19. Molecular Diagnostics in Allergy to Mammals -- 20. Extract-Based and Molecular Diagnostics in Fish Allergy -- 21. Allergens and Molecular Diagnostics of Shellfish Allergy -- 22. Allergens, Diagnostics, and Therapeutic Aspects in House Dust Mite Allergy -- 23. Cockroach, Tick, Storage Mite, and Other Arthropod Allergies: Molecular Aspects -- 24. Mold Allergens and Their Importance in Molecular Allergy Diagnosis -- 25. Latex Allergens: Source of Sensitization and Single Allergens -- Part IV: Designer Allergens, Hypoallergens and Fusion Allergens -- 26. Recombinant Allergens in Specific Immunotherapy -- 27. Definition and Design of Hypoallergenic Foods.
Format
e-Book
Location
Online
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Molecular Cytopathology

https://libcat.nshealth.ca/en/permalink/provcat40177
Bin Yang, Jianyu Rao, editors. --Cham: Springer , c2016.
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Location
Online
This book reviews the current application of molecular tools in cytopathology and serves as a concise handbook for those who provide care in this era of personalized medicine. Specifically, the text provides a comprehensive and concise review of the emerging molecular tests available clinically in different organ systems. It reviews the current data of molecular testing already applied in cytopathology, discusses some of the biomarkers with potential utility in cytopathology in the near future …
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Other Authors
Yang, Bin
Rao, Jianyu
Responsibility
Bin Yang, Jianyu Rao, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2016
Physical Description
1 online resource (xi, 293 p. : 37 illus. in color)
Series
Essentials in cytopathology
Series Vol.
26
Series Title
Essentials in cytopathology series
ISBN
9783319307411
9783319307398 (print ed.)
ISSN
1574-9053
Subjects (MeSH)
Cytodiagnosis - methods
Molecular Diagnostic Techniques - methods
Pathology, Molecular - methods
Abstract
This book reviews the current application of molecular tools in cytopathology and serves as a concise handbook for those who provide care in this era of personalized medicine. Specifically, the text provides a comprehensive and concise review of the emerging molecular tests available clinically in different organ systems. It reviews the current data of molecular testing already applied in cytopathology, discusses some of the biomarkers with potential utility in cytopathology in the near future and reviews the technical challenges in applying and validating molecular tools in various cytologic materials. Molecular Cytopathology will serve as a valuable resource for cytopathologists, cytotechnologists, pathology trainees, and clinicians with an interest in molecular applications in cytopathology.
Contents
1. Development and Validation of Molecular Testing on Cytologic Specimens -- 2. Molecular Techniques and Methods Applied in Cytology -- 3. Potential of Next-Generation Sequencing in Cytology -- 4. HPV Testing and Molecular Biomarkers in Cervical Cytology -- 5. Molecular Diagnostics in Thyroid Cytopathology -- 6. Molecular Markers in Head and Neck Cytology -- 7. Molecular Biomarkers in Pulmonary Cytology -- 8. Molecular Analysis of Breast Cancer in Cytology Samples -- 9. Molecular Pathology of Urine Cytology -- 10. Molecular Biomarkers of Pancreatobiliary and Gastrointestinal Tract Neoplasms -- 11. Molecular Biomarkers in Hematopoietic Neoplasms -- 12. Molecular Markers in Soft Tissue and Bone Tumors -- 13. Molecular Biomarkers in Body Fluid Cytology -- 14. Molecular Biomarkers in Prognostication of Uveal Melanoma -- 15. Current Status of Microfluidics-Assisted Cytology: The Application in Molecular Cytology.
Format
e-Book
Location
Online
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Molecular Diagnosis and Targeting for Thoracic and Gastrointestinal Malignancy

https://libcat.nshealth.ca/en/permalink/provcat43374
Yutaka Shimada, Katsuhiko Yanaga, editors. --Singapore: Springer , c2018.
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Online
This volume focuses on the clinical applications of molecular diagnosis and targeted therapy from the viewpoint of oncologists specializing in specific organs. In addition, it discusses the role of molecular diagnosis and targeted therapy in the course of surgical treatment. Recent, rapid advances in molecular biology have shed new light on the mechanisms of cancer progression, and molecularly targeted drugs have been used to treat a variety of malignant diseases. For the diagnosis and precise …
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Other Authors
Shimada, Yutaka
Yanaga, Katsuhiko
Responsibility
Yutaka Shimada, Katsuhiko Yanaga, editors
Place of Publication
Singapore
Publisher
Springer
Date of Publication
c2018
Physical Description
1 online resource (viii, 156 p.) : 42 illus., 35 illus. in color
Series Title
Current human cell research and applications
ISBN
9789811064692
9789811064685 (print ed.)
9789811064708 (print ed.)
ISSN
2522-073X
Subjects (MeSH)
Gastrointestinal Neoplasms - diagnosis
Gastrointestinal Neoplasms - genetics
Molecular Diagnostic Techniques - methods
Molecular Targeted Therapy - methods
Thoracic Neoplasms - diagnosis
Thoracic Neoplasms - genetics
Specialty
Medical Oncology
Molecular Medicine
Abstract
This volume focuses on the clinical applications of molecular diagnosis and targeted therapy from the viewpoint of oncologists specializing in specific organs. In addition, it discusses the role of molecular diagnosis and targeted therapy in the course of surgical treatment. Recent, rapid advances in molecular biology have shed new light on the mechanisms of cancer progression, and molecularly targeted drugs have been used to treat a variety of malignant diseases. For the diagnosis and precise treatment of cancer, analysis of the molecular background of the tumor is indispensable. However, there are both tumor-specific and comprehensive mechanisms involved in these processes. Accordingly, a firm grasp of molecular diagnosis and targeted therapies for different tumors is vital for clinicians and basic researchers alike. This book provides essential information and the latest findings on molecular diagnosis and targeted therapy for thoracic and gastrointestinal malignancies. Though primarily intended for clinical and basic oncologists, it also offers a useful guide for clinicians who are interested in this field and are considering getting started in molecular diagnosis and targeted therapy.
Contents
1. Molecular biology of lung cancer in relation to precision medicine -- 2. Molecular diagnosis and targeting for breast cancer -- 3. Clinical application of stem cell biology in esophageal cancer -- 4. Molecular diagnosis and targeted therapy for gastric cancer -- 5. Molecular diagnosis and targeted therapy for colorectal cancer -- 6. Molecular and immunologic targets for the treatment of hepatocellular carcinoma -- 7. Molecular diagnosis and targeting for biliary tract cancer -- 8. Molecular analysis for therapeutic targets of pancreatic cancer -- 9. Molecular targeted therapy and diagnosis for gastroenteropancreatic neuroendocrine tumors.
Format
e-Book
Location
Online
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Molecular Diagnostics : 12 Tests That Changed Everything

https://libcat.nshealth.ca/en/permalink/provcat39597
W. Edward Highsmith, Jr., editor. --New York, NY: Springer New York : Imprint: Humana Press , c2014.
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Location
Online
Molecular Diagnostics: 12 Tests That Changed Everything focuses on specific laboratory tests and emphasizes how the availability of these tests has altered how clinicians treat their patients. Presented as a standard outline, each chapter focuses on a specific molecular test and provides background on the test and its clinical applications. Continuing with some discussion on how the test is done, interpreted, and used clinically, each chapter then concludes with a discussion of how that test ha…
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Other Authors
Highsmith, Jr., W. Edward
Responsibility
W. Edward Highsmith, Jr., editor
Place of Publication
New York, NY
Publisher
Springer New York : Imprint: Humana Press
Date of Publication
c2014
Physical Description
1 online resource (xiii, 257 p. : 47 illus., 41 illus. in color)
Series Title
Molecular and translational medicine
ISBN
9781461481270
9781461481263 (print ed.)
Subjects (MeSH)
Genetic testing
Molecular Diagnostic Techniques
Abstract
Molecular Diagnostics: 12 Tests That Changed Everything focuses on specific laboratory tests and emphasizes how the availability of these tests has altered how clinicians treat their patients. Presented as a standard outline, each chapter focuses on a specific molecular test and provides background on the test and its clinical applications. Continuing with some discussion on how the test is done, interpreted, and used clinically, each chapter then concludes with a discussion of how that test has changed the way medicine is practiced with respect to the disease or condition in question. Authored by renowned experts in the field, Molecular Diagnostics: 12 Tests That Changed Everything is a valuable resource for pathologists, pathology residents, laboratory directors, development personnel, lab medicine fellows and those working in the broad area of oncology, infectious disease and genetics.
Contents
1. Clinical FISH Testing for the Diagnosis of Solid Tumors -- 2. Epidermal Growth Factor Receptor Testing in Lung Adenocarcinoma -- 3. The Human Epidermal Growth Factor Receptor 2 (HER2) -- 4. Tamoxifen and Irinotecan Pharmacogenomics -- 5. Hepatitis C Virus Testing -- 6. Laboratory Testing for HIV Infection: Advances after 27 years -- 7. Detection of Herpes Simplex Virus in Cerebrospinal Fluid using Real-time PCR -- 8. Toward a Safer Blood Supply: The Impact of Molecular Testing -- 9. Chromosomal Microarrays -- 10. BRCA1 and BRCA2 Testing in Inherited Breast Cancer -- 11. Cystic Fibrosis: Carrier Testing, Newborn Screening, and Diagnostic Testing -- 12. Newborn Screening by Tandem Mass Spectrometry and Molecular Confirmation -- 13. Next Generation Clinical Diagnostics: The Sequence of Events.
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e-Book
Location
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Molecular diagnostics and treatment of pancreatic cancer

https://libcat.nshealth.ca/en/permalink/provcat50939
Azmi, Asfar. (1st ed.) --Philadelphia, PA: Elsevier , 2014.
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Online
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Author
Azmi, Asfar
Edition
1st ed.
Place of Publication
Philadelphia, PA
Publisher
Elsevier
Date of Publication
2014
ISBN
9780124081031
Subjects (MeSH)
Biomarkers, Tumor
Pancreatic Neoplasms - diagnosis
Molecular Diagnostic Techniques
Pancreatic Neoplasms - genetics
Pancreatic Neoplasms - therapy
Signal Transduction
Notes
Access to this online resource is restricted to IWK Health Centre employees working from inside the hospital network.
Format
e-Book
Location
Online
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Molecular diagnostics and treatment of pancreatic cancer : systems and network biology approaches

https://libcat.nshealth.ca/en/permalink/provcat33143
edited by Asfar S. Azmi. --Amsterdam, Netherlands: Elsevier/AP , 2014.
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Molecular Diagnostics and Treatment of Pancreatic Cancer describes the different emerging applications of systems biology and how it is shaping modern pancreatic cancer research. This book begins by introducing the current state of the art knowledge, trends in diagnostics, progress in disease model systems as well as new treatment and palliative care strategies in pancreatic cancer. Specific sections are dedicated to enlighten the readers to newer discoveries that have emerged from gene expres…
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Other Authors
Azmi, Asfar S
Responsibility
edited by Asfar S. Azmi
Place of Publication
Amsterdam, Netherlands
Publisher
Elsevier/AP
Date of Publication
2014
Physical Description
1 online resource (xx, 446 p.)
ISBN
9781306642347 (electronic bk)
Subjects (MeSH)
Pancreatic Neoplasms - diagnosis
Molecular Diagnostic Techniques
Pancreatic Neoplasms - genetics
Pancreatic Neoplasms - therapy
Signal transduction
Tumor Markers, Biological
Subjects (LCSH)
Pancreas - Cancer - Molecular diagnosis
Pancreas - Cancer - Treatment
Pancreatic Neoplasms - diagnosis
Molecular Diagnostic Techniques
Pancreatic Neoplasms - genetics
Pancreatic Neoplasms - therapy
Signal Transduction
Tumor Markers, Biological
Abstract
Molecular Diagnostics and Treatment of Pancreatic Cancer describes the different emerging applications of systems biology and how it is shaping modern pancreatic cancer research. This book begins by introducing the current state of the art knowledge, trends in diagnostics, progress in disease model systems as well as new treatment and palliative care strategies in pancreatic cancer. Specific sections are dedicated to enlighten the readers to newer discoveries that have emerged from gene expression profiling, proteomics, metabolomics and systems level analyses of pancreatic cancer datasets.
Contents
Front Cover; MOLECULAR DIAGNOSTICS AND TREATMENT OF PANCREATIC CANCER: SYSTEMS AND NETWORK BIOLOGY APPROACHES; Copyright; DEDICATION; CONTENTS; PREFACE; ACKNOWLEDGMENTS; CONTRIBUTORS; Section I -- Current Trends and Advances in Pancreatic Cancer; Chapter 1 -- Epidemiology, Treatment, and Outcome of Pancreatic Cancer; INTRODUCTION; EPIDEMIOLOGY AND ETIOLOGY OF PANCREATIC CANCER; TYPES OF PANCREATIC CANCER; CLINICAL PRESENTATION OF PANCREATIC CANCER; DIAGNOSIS OF PANCREATIC CANCER; TREATMENT OF PANCREATIC CANCER; POTENTIALLY CURATIVE SURGICAL TREATMENT; ADJUVANT AND NEOADJUVANT TREATMENT -- PROGNOSIS OF PANCREATIC CANCEROUTLOOK; REFERENCES; Chapter 2 -- Advances in Primary Cell Culture of Pancreatic Cancer; INTRODUCTION; CELL CULTURE OF PDAC; ISOLATION AND ESTABLISHMENT PROCEDURE; CHARACTERIZATION OF CELL CULTURES; MORPHOLOGY; GENOTYPING; PHENOTYPING; SECOND LEVEL OF BIOLOGICAL MODELS; THREE-DIMENSIONAL CELL CULTURES; IN VIVO MODELS; APPLICATIONS; CONCLUSION; ACKNOWLEDGMENTS; REFERENCES; Chapter 3 -- Multimodal Therapies for Pancreatic Cancer; INTRODUCTION; CONCLUSION; REFERENCES; Chapter 4 -- The Role of Notch Signaling Pathway in the Progression of Pancreatic Cancer; INTRODUCTION -- NOTCH SIGNALING PATHWAYTHE ROLE OF NOTCH IN PC; NOTCH INHIBITION IS A NOVEL STRATEGY FOR PC TREATMENT; UNDERSTANDING NOTCH SIGNALING THROUGH SYSTEMS BIOLOGY; CONCLUSION; REFERENCES; Section II -- Gene Expression Profiling and Bioinformatics Analysis in Pancreatic Cancer; Chapter 5 -- Bioinformatics Analysis of Pancreas Cancer Genome in High-Throughput Genomic Technologies; INTRODUCTION; HETEROGENEITY AND QUALITY OF SAMPLES FOR HIGH-THROUGHPUT GENOMIC TECHNOLOGIES; MICROARRAYS; NEXT-GENERATION SEQUENCING; DATABASES AND RESOURCES; CONCLUSION AND FUTURE PERSPECTIVES; ACKNOWLEDGEMENTS; REFERENCES -- Chapter 6 -- Statistical Analysis of High-Dimensional Data for Pancreatic CancerINTRODUCTION; LASSO PENALIZED COX REGRESSION; DOUBLY REGULARIZED COX REGRESSION; PANCREATIC CANCER SURVIVAL ANALYSIS; ACKNOWLEDGMENTS; REFERENCES; Chapter 7 -- Gene Expression Profiling in Pancreatic Cancer; INTRODUCTION; SUMMARY; REFERENCES; Chapter 8 -- Genetic Susceptibility and Risk of Pancreatic Cancer; INTRODUCTION; FAMILIAL RISK OF PANCREATIC CANCER; RARE, HIGH-RISK PANCREATIC CANCER SUSCEPTIBILITY GENES AND MULTICANCER SYNDROMES; COMMON, LOW-RISK PANCREATIC CANCER SUSCEPTIBILITY LOCI -- COMMON PANCREATIC CANCER RISK LOCI IN NON-EUROPEAN POPULATIONSPATHWAY ANALYSES OF PANCREATIC CANCER GWAS DATA SETS; FUTURE GWAS AND GENE MAPPING APPROACHES; WEBSITES; REFERENCES; Section III -- Pancreatic Cancer Proteomics; Chapter 9 -- Proteomics in Pancreatic Cancer Translational Research; INTRODUCTION; OVERVIEW OF PROTEOMICS TECHNOLOGIES; PROTEOMICS STUDY OF PANCREATIC TISSUE; BLOOD BIOMARKER DISCOVERY; ANALYSIS OF PANCREATIC JUICE AND CYST FLUID; FUNCTIONAL AND HYPOTHESIS-DRIVEN PROTEOMIC STUDIES; POST-TRANSLATIONAL MODIFICATIONS; SUMMARY; ACKNOWLEDGMENT; REFERENCES -- Chapter 10 -- Proteomic Differences and Linkages between Chemoresistance and Metastasis of Pancreatic Cancer Using Knowledge-Based Pathway Analysis.
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Molecular diagnostics for dermatology : practical applications of molecular testing for the diagnosis and management of the dermatology patient

https://libcat.nshealth.ca/en/permalink/provcat34017
Gregory A. Hosler, Kathleen M. Murphy. --Heidelberg: Springer , c2014.
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This textbook presents the current (and near-future) state of affairs of molecular testing as it pertains to the dermatology patient. It focuses on practical applications of molecular diagnostics over a cross-section of dermatologic disease, including melanoma, lymphoma, soft tissue tumors, genodermatoses, and infectious disease. It includes practical advice to those ordering molecular tests as well as to those considering performing such tests, providing a potential template for a comprehensiv…
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Author
Hosler, Gregory A.
Other Authors
Murphy, Kathleen M.
Responsibility
Gregory A. Hosler, Kathleen M. Murphy
Place of Publication
Heidelberg
Publisher
Springer
Date of Publication
c2014
Physical Description
1 online resource (xviii, 356 pages)
ISBN
9783642540660 (electronic bk.)
9783642540653
Subjects (MeSH)
Molecular Diagnostic Techniques
Skin Diseases - diagnosis
Subjects (LCSH)
Skin - Diseases - Molecular diagnosis
Dermatology
Médecine
Abstract
This textbook presents the current (and near-future) state of affairs of molecular testing as it pertains to the dermatology patient. It focuses on practical applications of molecular diagnostics over a cross-section of dermatologic disease, including melanoma, lymphoma, soft tissue tumors, genodermatoses, and infectious disease. It includes practical advice to those ordering molecular tests as well as to those considering performing such tests, providing a potential template for a comprehensive dermatologic molecular diagnostics test menu. Pitfalls of interpretation and algorithmic approaches to testing are included. The textbook is directed towards all readers - clinicians, pathologists, laboratorians, and other inquisitive minds - independent of their level of molecular expertise, to provoke thought or perhaps even change practice. The context for the book is the rapid evolution of the field of molecular diagnostics, which is becoming more pervasive in all disciplines of medicine, including dermatology. This is indeed an exciting time in dermatology. Molecular testing is now incorporated into all aspects of patient management, including diagnostics (identifying and classifying disease), prognostics (predicting disease course), and theranostics (predicting response to therapy). For example, molecular tests are now used to detect germline mutations that result in genodermatoses, somatic genetic events that characterize tumors such as melanoma and sarcomas, and genetic material of otherwise undetectable infectious organisms. For melanoma and lymphoma, testing can potentially predict tumor behavior and modify patient staging. Regarding theranostics, molecular tests that identify specific mutations in proto-oncogenes, such as BRAF and others, are now used to predict which patients will respond to designer targeted therapies. Molecular theranostics has revolutionized the entire treatment paradigm for patients with advanced melanoma, replacing 'excise and pray' approaches with personalized medicine.
Contents
1. Introduction -- 2. Basics of Nucleic Acids and Molecular Biology -- 3. Molecular Methods -- 4. Melanoma. Part I. Risk Assessment, Diagnosis, and Prognosis: Using Molecular Tools to Diagnose Melanoma, Predict Its Behavior, and Evaluate for Inheritable Forms -- 5. Melanoma. Part II. Personalized Medicine: Using Molecular Tools to Guide Targeted Therapy -- 6. Leukemia and Lymphoma. Part I. Mycosis Fungoides and Sézary Syndrome: Using Molecular Tools to Aid in the Diagnosis, Staging, and Therapy for Mycosis Fungoides and Sézary Syndrome -- 7. Leukemia and Lymphoma. Part II: Primary Cutaneous B-Cell Lymphoma and Other Non-MF/SS HematopoieticTumors -- 8. Tumors of the Soft Tissue: Using Molecular Tools to Aid in the Diagnosis of Soft Tissue Tumors and the Management of the Sarcoma Patient -- 9. Genodermatoses. Part I: Muir- Torre Syndrome -- 10. Genodermatoses. Part II: Other Hereditary Dermatologic Disease -- 11. Infectious Disease Testing -- 12. Emerging Molecular Applications and Summary -- Appendix.
Format
e-Book
Location
Online
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Molecular diagnostics : for the clinical laboratorian

https://libcat.nshealth.ca/en/permalink/provcat22536
Coleman, William B. (2nd ed.) --Totowa, NJ: Humana Press , 2006.
Call Number
QY 25 M718 2006
Location
Dickson Building
Call Number
QY 25 M718 2006
Author
Coleman, William B
Other Authors
Tsongalis, Gregory J
Edition
2nd ed.
Place of Publication
Totowa, NJ
Publisher
Humana Press
Date of Publication
2006
Physical Description
567 p. + 1 CD-ROM
ISBN
1588293564
Subjects (MeSH)
Molecular Diagnostic Techniques
Clinical Laboratory Techniques
Genetic techniques
Format
Book
Location
Dickson Building
Loan Period
3 weeks
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Molecular Diagnostics in Cancer Patients

https://libcat.nshealth.ca/en/permalink/provcat44270
Kamla Kant Shukla, Praveen Sharma, Sanjeev Misra, editors. --Singapore: Springer , 2019.
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This book aims to bring together a broad variety of examples of the role of pharmacogenomics in current drug development, uncovering dynamic concentration-dependent drug responses on biological systems to understand pharmacodynamics responses in human cancer where genetic lesions serve as tumor markers and provide a basis for cancer diagnosis. The book describes methods and protocols applied in molecular diagnostics. It offers pathologists and researchers providing molecular diagnostic services…
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Other Authors
Shukla, Kamla Kant
Sharma, Praveen
Misra, Sanjeev
Responsibility
Kamla Kant Shukla, Praveen Sharma, Sanjeev Misra, editors
Place of Publication
Singapore
Publisher
Springer
Date of Publication
2019
Physical Description
1 online resource (viii, 341 p.) : 45 illus., 43 illus. in color
ISBN
9789811358777
9789811358760 (Print ed.)
9789811358784 (Print ed.)
Subjects (MeSH)
Biomarkers, Tumor
Molecular Diagnostic Techniques
Neoplasms - diagnosis
Pharmacogenetics
Specialty
Medical Oncology
Molecular Medicine
Abstract
This book aims to bring together a broad variety of examples of the role of pharmacogenomics in current drug development, uncovering dynamic concentration-dependent drug responses on biological systems to understand pharmacodynamics responses in human cancer where genetic lesions serve as tumor markers and provide a basis for cancer diagnosis. The book describes methods and protocols applied in molecular diagnostics. It offers pathologists and researchers providing molecular diagnostic services an array of the most recent and readily accessible reference to compare methods and techniques. Highlights include the molecular diagnosis of genetic aberrations by quantitative polymerase reaction (qPCR), sequence-specific oligonucleotide arrays, next-generation sequencing (NGS), CGH arrays-and methodologies directed at the detection of epigenetic events, high-throughput nucleic acid and protein arrays, direct sequencing and FISH-based methodologies, currently used in the diagnosis of solid tumors. The book also includes an innovative line of treatment in relation to the molecular prognosis, diagnosis and pharmacogenomics in the actual practice of clinical findings at molecular levels. The book covers the applications of numerous genetic testing methodologies; in approximately the chronological order of discovery and high-throughput diagnosis using advanced genomic approaches to identify such genes, in the search for novel drug targets and/or key determinants of drug reactions. It also promotes a wider understanding of molecular diagnostics among physicians, medical students, and scientists in academics, industry and corporate world.
Contents
1. Recent Advances in Molecular Diagnostic Approaches for Cancer -- 2. Molecular Diagnosis of Gall Bladder Cancer -- 3. Molecular Diagnostics for Lung Cancer -- 4. Predicting E3 Ubiquitin Ligases as Possible Promising Biomarkers for Brain Tumors -- 5. Molecular Diagnostics in Melanoma: An Update -- 6. Molecular Diagnostics in Breast Cancer -- 7. Molecular Diagnostics in Non-Hodgkin Lymphoma -- 8. Molecular Diagnosis of Cervical Cancer -- 9. Molecular Diagnostics in Colorectal Cancer -- 10. Molecular Diagnostics in Pancreatic Cancer -- 11. Molecular Diagnostics in Head and Neck Squamous Cell Carcinoma -- 12. Molecular Diagnostic in Prostate Cancer -- 13. Molecular Diagnostics in Renal Cancer -- 14. Molecular Biomarkers and Urinary Bladder Cancer (UBC) -- 15. Molecular Pathway and Fluorescence In Situ Hybridization Testing of ERBB2 (HER2) Gene Amplification in Invasive Ductal Carcinoma of Breast -- 16. Exploring Potential of RPPA Technique in Oral Cancer Biomarker Discovery Research -- 17. Molecular Diagnostics in Liver Cancer -- 18. Molecular Diagnosis of Uterine Cancer -- 19. Molecular Diagnosis in Ovarian Carcinoma.
Format
e-Book
Location
Online
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