Bone-implant interface in orthopedic surgery : basic science to clinical applications
https://libcat.nshealth.ca/en/permalink/provcat33691
Theofilos Karachalios, editor.
--London:
Springer
, c2014.
- Available Online
- View e-Book
- Location
- Online
What is the optimal design and fixation of the implants we use for orthopedic reconstructions? What is the gold standard for the management of patients requiring implants? Is there scope for improvement still further? Huge efforts have been made both by research scientists in orthopedics and the implant industry to furthering the options available for arthroplasty without necessarily considering the cost-effectiveness of this research to clinical outcomes. It has also become apparent that theor…
- Available Online
- View e-Book
- Other Authors
- Karachalios, Theofilos
- Responsibility
- Theofilos Karachalios, editor
- Place of Publication
- London
- Publisher
- Springer
- Date of Publication
- c2014
- Physical Description
- 1 online resource (xi, 342 pages)
- ISBN
- 9781447154099 (electronic bk.)
- 9781447154082
- Subjects (LCSH)
- Artificial joints
- Joints - Endoscopic surgery
- Joints - surgery
- Endoscopy
- Prostheses and Implants
- Surgical Orthopedics
- Molecular Medicine
- Abstract
- What is the optimal design and fixation of the implants we use for orthopedic reconstructions? What is the gold standard for the management of patients requiring implants? Is there scope for improvement still further? Huge efforts have been made both by research scientists in orthopedics and the implant industry to furthering the options available for arthroplasty without necessarily considering the cost-effectiveness of this research to clinical outcomes. It has also become apparent that theoretical and laboratory studies do not always match the results of long-term clinical studies of which there regretfully few of sufficient quality. The Editor and his carefully chosen selection of contributors critically evaluate data from basic science, experimental in vivo and in vitro biological and mechanical models, autopsy specimens and long-term clinical studies to answer these questions. Bone-Implant Interface in Orthopedic Surgery: Basic Science to Clinical Applications focuses on the bone-orthopedic implant interface in general and will be useful both for the novice who seeks a quick introduction to this specific topic and for more experienced surgeons who seek an in depth critical review of current practices.
- Contents
- Current evidence in designs and fixation surfaces in total hip arthroplasty -- Early and late mechanical stability of the cementless bone-implant interface in total joint arthroplasty -- Bone-cement interface in total joint arthroplasty -- The implant-cement interface in total hip arthroplasty -- Cobalt-chrome porous coated implant-bone interface in total joint arthroplasty -- Titanium porous-coated implant-bone interface in total joint arthroplasty -- Grit-blasted implant bone interface in total joint arthroplasty -- HA coated implant: bone interface in total joint arthroplasty -- Trabecular metal: bone interface in total joint arthroplasty -- Assessment of a failed (painful?) total joint arthroplasty -- The biology of aseptic loosening -- Cement-bone interface in revision arthroplasty -- Cementless fully porous-coated implant-bone interface in revision total hip arthroplasty -- Cementless tapered fluted implant-bone interface in revision total joint arthroplasty -- Bone-graft and implant-graft interface in total hip arthroplasty -- The effect of pharmacological agents on the bone implant interface -- Bone-implant interface in biofilm-associated bone and joint infections -- Modular interfaces -- Local and distant reaction to metallic wear debris -- Bone-implant interface in spine surgery -- Bone-tendon and bone-ligament interface -- Bone-implant interface in patients with neoplasmatic disease.
- Format
- e-Book
- Location
- Online
Cellular and Molecular Basis of Mitochondrial Inheritance : Mitochondrial Disease and Fitness
https://libcat.nshealth.ca/en/permalink/provcat44497
Peter Sutovsky, editor.
--Cham:
Springer
, c2019.
- Available Online
- View e-Book
- Location
- Online
This new volume of our successful book series Advances in Anatomy, Embryology and Cell Biology is focused on mitochondrial inheritance in humans and both vertebrate and invertrebate animals including Drosophila, C. elegans, bivalve molusc Mytilus and livestock mammals. Special consideration is given to cellular mechanisms promoting uniparental inheritance of mitochondria and mitochondrial genes, evolutionary perspectives, and biomedical and epidemiological considerations. Contributed by five di…
- Available Online
- View e-Book
- Other Authors
- Sutovsky, Peter
- Responsibility
- Peter Sutovsky, editor
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2019
- Physical Description
- 1 online resource (xi, 126 p.) : 28 illus., 24 illus. in color
- Series Vol.
- 231
- Series Title
- Advances in anatomy, embryology and cell biology
- ISBN
- 9783030045708
- 9783030045692 (Print ed.)
- 9783030045715 (Print ed.)
- ISSN
- 0301-5556
- Subjects (MeSH)
- DNA, Mitochondrial
- Extrachromosomal Inheritance
- Genes, Mitochondrial
- Mitochondria - genetics
- Specialty
- Cell Biology
- Genetics, Medical
- Molecular Medicine
- Abstract
- This new volume of our successful book series Advances in Anatomy, Embryology and Cell Biology is focused on mitochondrial inheritance in humans and both vertebrate and invertrebate animals including Drosophila, C. elegans, bivalve molusc Mytilus and livestock mammals. Special consideration is given to cellular mechanisms promoting uniparental inheritance of mitochondria and mitochondrial genes, evolutionary perspectives, and biomedical and epidemiological considerations. Contributed by five distinguished mitochondrial research teams from around the world, this volume will target a wide audience of physiologists, anatomists, cell, and developmental and evolutionary biologists, as well as physicians, veterinarians, livestock specialists and biomedical researchers.
- Contents
- Autophagosomal Sperm Organelle Clearance and mtDNA Inheritance in C. elegans -- Doubly Uniparental Inheritance of mtDNA: An Unappreciated Defiance of a General Rule -- Exogenous Factors May Differentially Influence the Selective Costs of mtDNA Mutations -- Transmission of Dysfunctional Mitochondrial DNA and Its Implications for Mammalian Reproduction -- Mitochondria Inspire a Lifestyle.
- Format
- e-Book
- Location
- Online
Cellular and molecular immunology
https://libcat.nshealth.ca/en/permalink/provcat33146
editors Abul K. Abbas, Andrew H. Lichtman, Shiv Pillai ; illustrations by David L. Baker.
(10th ed.)
--Philadelphia, PA:
Elsevier
, c2022.
- Available Online
- View e-Book
- Access
- Registration required for PDF access.
- Location
- Online
Well-written, readable, and superbly illustrated, Cellular and Molecular Immunology, 10th Edition, continues the tradition of excellence established through multiple editions of this bestselling text. Offering an unparalleled introduction to this complex field, it retains a practical, clinical focus while updating and revising all content to ensure clarity and comprehension, bringing readers fully up to date with new and emerging information in this challenging area.
- Available Online
- View e-Book
- Other Authors
- Abbas, Abul K.
- Lichtman, Andrew H.
- Pillai, Shiv
- Responsibility
- editors Abul K. Abbas, Andrew H. Lichtman, Shiv Pillai ; illustrations by David L. Baker
- Edition
- 10th ed.
- Place of Publication
- Philadelphia, PA
- Publisher
- Elsevier
- Date of Publication
- c2022
- Physical Description
- 1 online resource, 600 p.
- ISBN
- 9780323757485
- Subjects (MeSH)
- Immunity, Cellular
- Antibody Formation - immunology
- Antigens - immunology
- Immune System Diseases - immunology
- Lymphocytes - immunology
- Subjects (LCSH)
- Immunity, Cellular
- Antibody Formation - immunology
- Antigens - immunology
- Immune System Diseases - immunology
- Lymphocytes - immunology
- Cellular immunity
- Molecular immunology
- Abstract
- Well-written, readable, and superbly illustrated, Cellular and Molecular Immunology, 10th Edition, continues the tradition of excellence established through multiple editions of this bestselling text. Offering an unparalleled introduction to this complex field, it retains a practical, clinical focus while updating and revising all content to ensure clarity and comprehension, bringing readers fully up to date with new and emerging information in this challenging area.
- Access
- Registration required for PDF access.
- Format
- e-Book
- Location
- Online
Clinical Molecular Diagnostics
https://libcat.nshealth.ca/en/permalink/provcat46964
- Available Online
- View e-Book
- Responsibility
- Shiyang Pan, Jinhai Tang
- Publisher
- Springer
- Date of Publication
- 2021
- Physical Description
- 1 online resource (xxviii, 889 pages) : illustrations
- ISBN
- 9789811610370
- Specialty
- Diagnosis
- Molecular Medicine
- Format
- e-Book
- Location
- Online
Damage-Associated Molecular Patterns in Human Diseases : Volume 1. Injury-Induced Innate Immune Responses
https://libcat.nshealth.ca/en/permalink/provcat42536
Walter Gottlieb Land.
--Cham:
Springer
, c2018.
- Available Online
- View e-Book
- Location
- Online
This book presents current understanding of the importance of modern immunology in the etiopathogenesis of human diseases and explores how this understanding is impacting on diagnosis, prognosis, treatment, and prophylaxis. As the core of modern immunology, the "danger/injury model" is introduced and addressed throughout the book. Volume I of the book describes the network of damage-associated molecular pattern molecules (DAMPs) and examines the central role of DAMPs in cellular stress response…
- Available Online
- View e-Book
- Author
- Land, Walter Gottlieb
- Responsibility
- Walter Gottlieb Land
- Alternate Title
- Injury-induced innate immune responses
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2018
- Physical Description
- 1 online resource (xlviii, 870 p.) : 115 illus., 102 illus. in color
- ISBN
- 9783319786551
- 9783319786544 (print ed.)
- 9783319786568 (print ed.)
- Subjects (MeSH)
- Biomarkers - analysis
- Immunologic Techniques
- Molecular Medicine
- Pathogen-Associated Molecular Pattern Molecules
- Stress, Physiological - immunology
- Wounds and Injuries - immunology
- Specialty
- Diagnosis
- Molecular Medicine
- Pathology
- Abstract
- This book presents current understanding of the importance of modern immunology in the etiopathogenesis of human diseases and explores how this understanding is impacting on diagnosis, prognosis, treatment, and prophylaxis. As the core of modern immunology, the "danger/injury model" is introduced and addressed throughout the book. Volume I of the book describes the network of damage-associated molecular pattern molecules (DAMPs) and examines the central role of DAMPs in cellular stress responses and associated regulated cell death, the promotion and resolution of inflammation, the activation of innate lymphoid cells and unconventional T cells, the stimulation of adaptive immunity, and tissue repair. The significance of DAMPs in a wide range of human diseases will then be explored in Volume II of the book, with discussion of the implications of injury-induced innate immunity for present and future treatments. This book is written for professionals from all medical and paramedical disciplines who are interested in the introduction of innovative data from immunity and inflammation research into clinical practice. The readership will include practitioners and clinicians such as hematologists, rheumatologists, traumatologists, oncologists, intensive care anesthetists, endocrinologists such as diabetologists, psychiatrists, neurologists, pharmacists, and transplantologists.
- Contents
- Part I. The Three Major Paradigms in Modern Immunology -- Prologue: The Term "Immunity" over the Course of Time -- The Three Major Paradigms in Immunology -- Epilogue: What Major Paradigm in Immunology Comes Next? -- Part II. The Innate Immune System: an Organ of Perception Determined to Maintain Homeostasis -- Prologue: The Guardians of Homeostasis -- Innate Immune Recognition Molecules -- Epilogue: The Innate Immune System: a Global Player in Health and Disease -- Part III. The Whole Family of Mammalian Innate Immune Cells -- Prologue: The Whole Body as an Immune System? -- Mobile Innate Immune Cells -- Sessile Innate Immune Cells -- Epilogue: The Whole Body as an Immune Defence System -- Part IV. The World of DAMPs. Prologue: About DAMPs, PAMPs and MAMPs -- Endogenous DAMPs, Category I: Constitutively Expressed Native Molecules (Cat. I DAMPs) -- Endogenous DAMPs, Category II: Constitutively Expressed, Injury-Modified Molecules (Cat. II DAMPs) -- Endogenous DAMPs, Category III: Inducible DAMPs (Cat. III DAMPs) -- Exogenous DAMPs, Category IV (Cat. IV DAMPs) -- Epilogue: The Well-Dosed Work of DAMPs in their Commission to Restore and Maintain Homeostasis -- Part V. Cellular Stress Responses and Regulated Cell Death -- Prologue: Innate Immune Tools to Defend against Stressful Injury: Success and Failure -- Cell-Autonomous (Cell-Intrinsic) Stress Responses -- Regulated Cell Death -- Epilogue: The Horror of an Injury-Induced Avalanche of DAMPs -- Part VI. Innate Immune Effector Responses -- Prologue: The Various Facets of Innate Immune Effector Responses -- Cellular Inflammatory Responses -- Humoral Innate Immune Effector Responses -- Regulation of Innate Inflammatory Responses -- Epilogue to Part VI -- Part VII. Function of Innate Lymphoid Cells and Unconventional T Cells with Partial Innate Function -- Prologue: The "Ready-to-Go" Lymphocytes of the Immune System -- Activating and Function of Innate Lymphoid Cells -- Activating and Function of Unconventional T Cells -- Epilogue: Killer Lymphocytes as Tools for Future Immunotherapeutic Approaches -- Part VIII. DAMPs Promoting Adaptive Immunity and Tissue Repair -- Prologue: The "Long Arm" of DAMPs in Shaping Adaptive Immune Responses and Tissue Repairing Processes -- Antigen Uptake, Processing and Presentation by Dendritic Cells -- Antigen in the Presence of DAMPs Induces Immunostimulatory Dendritic Cells to Promote "Destructive" Acquired Immune Responses -- Antigen in the Absence of DAMPs Promotes Immunotolerance: the Role of Dendritic Cells and Regulatory T Cells -- An Impressive Example of Peripheral Tolerance against Nonself: Tolerance to Commensal Bacterial and Dietary Protein Antigens -- Immunometabolism of Dendritic Cells and T Cells -- Role of DAMPs in Tissue Regeneration and Repair -- Epilogue: DAMPs as Key Players in the Pathogenesis of Many Human Diseases.
- Format
- e-Book
- Location
- Online
Damage-Associated Molecular Patterns in Human Diseases : Volume 2: Danger Signals as Diagnostics, Prognostics, and Therapeutic Targets
https://libcat.nshealth.ca/en/permalink/provcat45638
Walter Gottlieb Land.
--Cham:
Springer
, c2020.
- Available Online
- View e-Book
- Location
- Online
This book is a continuance of the topic: “DAMPs in Human Diseases”, the basics of which were described in a first volume by the same author. This second volume presents our current understanding of the impact of sterile stress/injury-induced innate immune responses on the etiopathogenesis of human diseases by focusing on those diseases that are pathogenetically dominated by DAMPs, i.e., on polytrauma, various solid organ injuries (brain, lung, kidney, liver), atherosclerosis, and cerebro-cardio…
- Available Online
- View e-Book
- Author
- Land, Walter Gottlieb
- Responsibility
- Walter Gottlieb Land
- Alternate Title
- Danger signals as diagnostics, prognostics, and therapeutic targets
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2020
- Physical Description
- 1 online resource (xxxix, 629 p.) : 45 illus. in color
- ISBN
- 9783030538682
- 9783030538675 (Print ed.)
- 9783030538699 (Print ed.)
- 9783030538705 (Print ed.)
- Subjects (MeSH)
- Biomarkers
- Immunologic Techniques
- Molecular Medicine
- Pathogen-Associated Molecular Pattern Molecules
- Stress, Physiological - immunology
- Wounds and Injuries - immunology
- Specialty
- Diagnosis
- Molecular Medicine
- Pathology
- Abstract
- This book is a continuance of the topic: “DAMPs in Human Diseases”, the basics of which were described in a first volume by the same author. This second volume presents our current understanding of the impact of sterile stress/injury-induced innate immune responses on the etiopathogenesis of human diseases by focusing on those diseases that are pathogenetically dominated by DAMPs, i.e., on polytrauma, various solid organ injuries (brain, lung, kidney, liver), atherosclerosis, and cerebro-cardiovascular diseases. Our growing understanding of the pathogenetic function of activating DAMPs and suppressive DAMPs (“SAMPs”) is used as a point of departure to explore how these molecules can be used as biomarkers to extend and improve current diagnostic and prognostic modalities. Moreover, this new knowledge about the pathogenetic function of DAMPs and SAMPs is taken as a sound and plausible reason for discussing their implications for present and future treatment of the diseases addressed here. In this context, the focus is on the potential of DAMPs as future therapeutic targets and SAMPs as future therapeutics, applied in strict compliance with safety precautions, as also recommended in this work. The book is intended for professionals from all medical and paramedical disciplines who are interested in applying innovative data from inflammation and immunity research to clinical practice. The readership will include practitioners and clinicians working in the broad field of acute and chronic inflammatory/fibrotic diseases, in particular, traumatologists and intensivists; neurologists and neurosurgeons; cardiologists and cardiac surgeons; pulmonologists and thoracic surgeons; vascular surgeons; nephrologists; gastroenterologists and hepatologists; and pharmacists. Also available: Damage-Associated Molecular Patterns in Human Diseases, Vol. 1: Injury-Induced Innate Immune Responses.
- Contents
- Part I. Prologue -- Perspectives of the Danger/Injury Model in Immunology -- Part II. A Select, Clinically Oriented Update of Topics Presented in “Damage-Associated Molecular Patterns in Human Diseases, Volume 1: Injury-Induced Innate Immune Responses" -- Pattern Recognition Molecules -- The Growing World of DAMPs -- The Growing Clinical Relevance of Cellular Stress Responses and Regulated Cell Death -- DAMP-Promoted Efferent Innate Immune Responses in Human Diseases: Inflammation -- DAMP-Promoted Efferent Innate Immune Responses in Human Diseases: Fibrosis -- Part III. DAMPs and SAMPs in Traumatic Disorders, Atherosclerosis, and Cerebro-Cardiovascular Diseases -- DAMPs and SAMPs as Molecular Biomarkers, Therapeutic Targets, and Therapeutics -- DAMP-Controlled and Uncontrolled Responses to Trauma: Wound Healing and Polytrauma -- Solid Organ Injury -- Atherosclerosis -- Cerebro - Cardiovascular Diseases -- Part IV. Epilogue -- The “DAMPome” as a Key Player in the Pathogenesis of Human Diseases.
- Format
- e-Book
- Location
- Online
Hepatitis C viruses : genomes and molecular biology
https://libcat.nshealth.ca/en/permalink/provcat23039
Tan, Seng-Lai.
--Wymondham, Norfolk, UK:
Horizon Bioscience
, 2006.
- Call Number
- QW 170 H529 2006
- Location
- Dickson Building
- Call Number
- QW 170 H529 2006
- Author
- Tan, Seng-Lai
- Place of Publication
- Wymondham, Norfolk, UK
- Publisher
- Horizon Bioscience
- Date of Publication
- 2006
- Physical Description
- 469 p.
- ISBN
- 1904933203
- Subjects (MeSH)
- Hepacivirus - genetics
- Genomics
- Molecular Biology
- Specialty
- Genetics, Medical
- Molecular Medicine
- Virology
- Format
- Book
- Location
- Dickson Building
- Loan Period
- 3 weeks
Imaging and Metabolism
https://libcat.nshealth.ca/en/permalink/provcat43247
Jason S. Lewis, Kayvan R. Keshari, editors.
--Cham:
Springer
, c2018.
- Available Online
- View e-Book
- Location
- Online
This book presents advanced molecular imaging techniques used to assess metabolic function. Covering state-of-the art modalities, it discusses the evaluation of a wide range of diseases that have a metabolic component, including cancer, inflammatory conditions, diabetes, neurodegeneration, and cardiovascular disorders. Imaging provides a quantitative perspective to the assessment of metabolic function and complements genetic analysis of disorders related to disrupted metabolism. Organized into …
- Available Online
- View e-Book
- Other Authors
- Lewis, Jason S.
- Keshari, Kayvan R.
- Responsibility
- Jason S. Lewis, Kayvan R. Keshari, editors
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2018
- Physical Description
- 1 online resource (xiii, 331 p.) : 195 illus., 165 illus. in color
- ISBN
- 9783319614014
- 9783319613994 (print ed.)
- 9783319614007 (print ed.)
- 9783319870731 (print ed.)
- Subjects (MeSH)
- Biomarkers - metabolism
- Metabolic Diseases - diagnostic imaging
- Metabolomics
- Molecular Imaging - methods
- Specialty
- Diagnostic Imaging
- Molecular Medicine
- Abstract
- This book presents advanced molecular imaging techniques used to assess metabolic function. Covering state-of-the art modalities, it discusses the evaluation of a wide range of diseases that have a metabolic component, including cancer, inflammatory conditions, diabetes, neurodegeneration, and cardiovascular disorders. Imaging provides a quantitative perspective to the assessment of metabolic function and complements genetic analysis of disorders related to disrupted metabolism. Organized into four parts, the book highlights basic principles in molecular imaging techniques; metabolic imaging approaches, including magnetic resonance imaging (MRI), single-photon emission computed tomography (SPECT), positron emission tomography (PET), and hybrid modalities; metabolic diseases; and future perspectives. Featuring contributions from leading authorities in radiology, oncology, cardiology, and neurology, Imaging and Metabolism is a pioneering exploration of the role of imaging modalities in assessing the physiological status of abnormal cells and diagnosing disease.
- Contents
- Part I. Basic Principles -- 1. Molecular Imaging and Molecular Imaging Technologies -- 2. A Topical Report on the Design Principles of Metabolism -- Part II. Metabolic Imaging Approaches -- 3. Overview of Positron-Emission Tomography Tracers for Metabolic Imaging -- 4. Introduction: MRI/MRS as Metabolic Imaging Tools -- 5. Metabolic Imaging Approaches: Optical Imaging -- Part III. Metabolic Diseases -- 6. Cancer Metabolism -- 7. Inflammation and Immune Metabolism -- 8. Imaging in Diabetes -- 9. Brain Disorders -- 10. Fatty Liver Disease -- 11. Imaging Myocardial Metabolism -- 12. Other Metabolic Syndromes.
- Format
- e-Book
- Location
- Online
Anne C. Chiang, Roy S. Herbst.
Humana
, 2021.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Responsibility
- Anne C. Chiang, Roy S. Herbst
- Publisher
- Humana
- Date of Publication
- 2021
- Physical Description
- 1 online resource (vi, 264 pages) : illustrations
- Series Title
- Current cancer research
- ISBN
- 9783030740283
- Specialty
- Medical Oncology
- Research
- Molecular Medicine
- Format
- e-Book
- Location
- Online
Molecular Applications in Cytology
https://libcat.nshealth.ca/en/permalink/provcat42591
Fernando C. Schmitt, editor.
--Cham:
Springer
, c2018.
- Available Online
- View e-Book
- Location
- Online
This book is intended for practicing pathologists and cytopathologists, as well as for pathology trainees and cytotechnicians. It starts with a detailed description of the extremely important pre-analytical phase for molecular testing followed by a presentation of the key tests and their application in different organs, e.g. the lung or thyroid. Step-by-step instructions for the different assays, reporting and clinical integration of the test results are discussed. The authors help the reader t…
- Available Online
- View e-Book
- Other Authors
- Schmitt, Fernando C.
- Responsibility
- Fernando C. Schmitt, editor
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2018
- Physical Description
- 1 online resource (viii, 268 p.) : 61 illus., 60 illus. in color
- ISBN
- 9783319749426
- 9783319749402 (print ed.)
- 9783319749419 (print ed.)
- Subjects (MeSH)
- Cytological Techniques
- Molecular Medicine
- Specialty
- Cell Biology
- Molecular Medicine
- Abstract
- This book is intended for practicing pathologists and cytopathologists, as well as for pathology trainees and cytotechnicians. It starts with a detailed description of the extremely important pre-analytical phase for molecular testing followed by a presentation of the key tests and their application in different organs, e.g. the lung or thyroid. Step-by-step instructions for the different assays, reporting and clinical integration of the test results are discussed. The authors help the reader to benefit from their experiences by providing a valuable tool for the implementation of these techniques in daily practice. Though the use of molecular techniques is well established in surgical biopsies, to date they are not widely used in connection with cytological material. However, in some fields like lung cancer or aspirates from the pancreas and biliary tract the only available material for diagnosis is the cytological preparation a fact that has created a need for the standardization of molecular techniques on cytology.
- Contents
- Why Cytology for Molecular Testing? Pros and Cons -- How to Prepare Cytological Samples for Molecular Testing -- Molecular Tests Use in Cytological Material (Analytical Phase) -- Molecular Cytology Applications on Head and Neck -- Molecular Cytology Applications on Lung -- Molecular Cytology of Serous Effusions -- Molecular Cytology Applications on Urine -- Molecular Cytology Applications on Gynecological Cytology -- Molecular Applications in Hematolymphoid Cytology -- Molecular Cytology Application on Thyroid -- Molecular Cytology Applications on Pancreas and Biliary Tract -- Molecular Cytology Applications in Soft Tissue (Pediatric tumors) -- Molecular Cytology Applications in Metastases -- Clinical Integration of Molecular Results on Cytology (Post-analytical Phase).
- Format
- e-Book
- Location
- Online
Molecular biology
https://libcat.nshealth.ca/en/permalink/provcat32198
David P. Clark, Nanette Jean Pazdernik, Michelle R. McGehee.
(3rd ed.)
--London, UK:
Elsevier
, c2019.
- Available Online
- View e-Book
- Access
- Registration required for PDF access.
- Location
- Online
Molecular Biology, Third Edition, provides a thoroughly revised, invaluable resource for college and university students in the life sciences, medicine and related fields. This esteemed text continues to meet the needs of students and professors by offering new chapters on RNA, genome defense, and epigenetics, along with expanded coverage of RNAi, CRISPR, and more ensuring topical content for a new class of students. This volume effectively introduces basic concepts that are followed by more s…
- Available Online
- View e-Book
- Author
- Clark, David P.
- Other Authors
- Pazdernik, Nanette Jean
- Responsibility
- David P. Clark, Nanette Jean Pazdernik, Michelle R. McGehee
- Edition
- 3rd ed.
- Place of Publication
- London, UK
- Publisher
- Elsevier
- Date of Publication
- c2019
- Physical Description
- 1 online resource, 1006 p.
- ISBN
- 9780128132883
- Subjects (MeSH)
- Cell Physiological Phenomena - genetics
- Genetic phenomena
- Molecular Biology - methods
- Subjects (LCSH)
- Molecular biology
- Molecular genetics
- Cell Physiological Phenomena - genetics
- Genetic Phenomena
- Molecular Biology - methods
- Genetics
- Specialty
- Cell Biology
- Molecular Medicine
- Abstract
- Molecular Biology, Third Edition, provides a thoroughly revised, invaluable resource for college and university students in the life sciences, medicine and related fields. This esteemed text continues to meet the needs of students and professors by offering new chapters on RNA, genome defense, and epigenetics, along with expanded coverage of RNAi, CRISPR, and more ensuring topical content for a new class of students. This volume effectively introduces basic concepts that are followed by more specific applications as the text evolves.
- Access
- Registration required for PDF access.
- Format
- e-Book
- Location
- Online
Molecular cancer
https://libcat.nshealth.ca/en/permalink/provcat16226
- Available Online
- View e-Journal
- Publisher
- BioMed Central
- Holdings
- Vol 1, 2002 -
- ISSN
- 1476-4598
- Specialty
- Medical Oncology
- Molecular Medicine
- Format
- e-Journal
- Location
- Online
Molecular cancer research
https://libcat.nshealth.ca/en/permalink/provcat16231
- Available Online
- View e-Journal
- Continues
- Cell growth and differentiation
- Publisher
- AACR Press
- Holdings
- Vol 1, 2002 -
- ISSN
- 1541-7786
- Specialty
- Medical Oncology
- Molecular Medicine
- Format
- e-Journal
- Location
- Online
Molecular cancer therapeutics
https://libcat.nshealth.ca/en/permalink/provcat16230
- Available Online
- View e-Journal
- Publisher
- AACR Press
- Holdings
- Vol 1, 2001 -
- ISSN
- 1535-7163
- Specialty
- Medical Oncology
- Molecular Medicine
- Format
- e-Journal
- Location
- Online
Molecular Determinants of Head and Neck Cancer
https://libcat.nshealth.ca/en/permalink/provcat42783
Barbara Burtness, Erica A. Golemis, editors.
(Second edition)
--Cham:
Humana Press
, c2018.
- Available Online
- View e-Book
- Location
- Online
Squamous cell cancers of the head and neck (SCCHN), also known as head and neck cancers (HNC) encompass malignancies of the oral cavity, larynx, nasopharynx and pharynx, and are diagnosed in over 500,000 patients worldwide each year, accounting for 5% of all malignancies. It is estimated that approximately 50,000 patients develop head and neck cancer annually in the United States, of whom approximately 50% succumb to this cancer. For most cases of SCCHN, treatment is multimodal, often combining…
- Available Online
- View e-Book
- Other Authors
- Burtness, Barbara
- Golemis, Erica A.
- Responsibility
- Barbara Burtness, Erica A. Golemis, editors
- Edition
- Second edition
- Place of Publication
- Cham
- Publisher
- Humana Press
- Date of Publication
- c2018
- Physical Description
- 1 online resource (vi, 629 p.) : 68 illus., 62 illus. in color
- Series Title
- Current cancer research
- ISBN
- 9783319787626
- 9783319787619 (print ed.)
- 9783319787633 (print ed.)
- ISSN
- 2199-2584
- Subjects (MeSH)
- Head and Neck Neoplasms - etiology
- Head and Neck Neoplasms - genetics
- Head and Neck Neoplasms - therapy
- Specialty
- Medical Oncology
- Molecular Medicine
- Abstract
- Squamous cell cancers of the head and neck (SCCHN), also known as head and neck cancers (HNC) encompass malignancies of the oral cavity, larynx, nasopharynx and pharynx, and are diagnosed in over 500,000 patients worldwide each year, accounting for 5% of all malignancies. It is estimated that approximately 50,000 patients develop head and neck cancer annually in the United States, of whom approximately 50% succumb to this cancer. For most cases of SCCHN, treatment is multimodal, often combining surgery or irradiation with chemotherapy; even successfully treated patients frequently experience durable and severe side effects. Improving cure rates and reducing chronic morbidity are urgent clinical needs for head and neck cancer. However, in contrast to cancer types such as breast or prostate that have been much studied and have well-defined biology, until recently, relatively few researchers investigated the molecular basis of HNC, making it difficult to design targeted treatments with better efficacy and less debilitating side effects. This volume will provide an overview of the factors contributing to disease pathogenesis, including the recognition of discrete molecular subtypes with distinct etiology, prognosis, and treatment response. This volume will familiarize the reader with the critical signaling pathways and oncogenic drivers for HNC. It will outline the differences between HPV-positive and HPV-negative disease, and how these differences affect treatment choice and outcome. The book will emphasize developments in the past five years, including the growing understanding of the genomic and epigenomic features of the disease based on analysis of next generation sequencing (NGS) data, and timely topics such as the analysis of HNC stem cell populations, non-coding mRNAs, and inflammatory response. It will address exciting new therapeutic approaches such as the use of immunotherapies to treat HNC patients. Overall, the book will provide the reader with current understanding of the biology and treatment of the disease, and describe timely questions that will guide future research aimed at controlling and curing this disease.
- Contents
- 1. Overview: The Pathobiology of Head and Neck Cancer -- 2. Targeting the ErbB Family in Head and Neck Cancer -- 3. c-MET in Head and Neck Squamous Cell Carcinoma -- 4. Transforming Growth Factor Beta (TGF-ß) Signaling in Head and Neck Squamous Cell Carcinoma (HNSCC) -- 5. The PI3K Signaling Pathway in Head and Neck Squamous Cell Carcinoma -- 6. Jak/STAT Signaling in Head and Neck Cancer -- 7. Molecular Regulation of Cell Cycle and Cell Cycle-Targeted Therapies in Head and Neck Squamous Cell Carcinoma (HNSCC -- 8. Role of the NOTCH Signaling Pathway in Head and Neck Cancer -- 9. P53 in Head and Neck Squamous Cell Carcinoma -- 10. APOBEC as an Endogenous Mutagen in Cancers of the Head and Neck -- 11. The Genome-Wide Molecular Landscape of HPV-Driven and HPV-Negative Head and Neck Squamous Cell Carcinoma -- 12. Epigenetic Changes and Epigenetic Targets in Head and Neck Cancer -- 13. Inflammation and Head and Neck Squamous Cell Carcinoma -- 14. Immunotherapy in Head and Neck Squamous Cell Carcinoma (HNSCC -- 15. The Clinical Impact of Hypoxia in Head and Neck Squamous Cell Carcinoma -- 16. Angiogenesis and Anti-angiogenic Therapy in Head and Neck Cancer -- 17. FAK as a Target for Therapy in Head and Neck Cancer -- 18. Diversity of Wnt/ß-Catenin Signaling in Head and Neck Cancer: Cancer Stem Cells, Epithelial-to-Mesenchymal Transition, and Tumor Microenvironment -- 19. Hyaluronan-Mediated CD44 Signaling Activates Cancer Stem Cells in Head and Neck Cancer -- 20. Biology and Epidemiology of Human Papillomavirus-Related Head and Neck Cancer -- 21. Treatment Paradigms in HPV-Associated SCCHN.
- Format
- e-Book
- Location
- Online
Molecular Diagnosis and Targeting for Thoracic and Gastrointestinal Malignancy
https://libcat.nshealth.ca/en/permalink/provcat43374
Yutaka Shimada, Katsuhiko Yanaga, editors.
--Singapore:
Springer
, c2018.
- Available Online
- View e-Book
- Location
- Online
This volume focuses on the clinical applications of molecular diagnosis and targeted therapy from the viewpoint of oncologists specializing in specific organs. In addition, it discusses the role of molecular diagnosis and targeted therapy in the course of surgical treatment. Recent, rapid advances in molecular biology have shed new light on the mechanisms of cancer progression, and molecularly targeted drugs have been used to treat a variety of malignant diseases. For the diagnosis and precise …
- Available Online
- View e-Book
- Other Authors
- Shimada, Yutaka
- Yanaga, Katsuhiko
- Responsibility
- Yutaka Shimada, Katsuhiko Yanaga, editors
- Place of Publication
- Singapore
- Publisher
- Springer
- Date of Publication
- c2018
- Physical Description
- 1 online resource (viii, 156 p.) : 42 illus., 35 illus. in color
- Series Title
- Current human cell research and applications
- ISBN
- 9789811064692
- 9789811064685 (print ed.)
- 9789811064708 (print ed.)
- ISSN
- 2522-073X
- Subjects (MeSH)
- Gastrointestinal Neoplasms - diagnosis
- Gastrointestinal Neoplasms - genetics
- Molecular Diagnostic Techniques - methods
- Molecular Targeted Therapy - methods
- Thoracic Neoplasms - diagnosis
- Thoracic Neoplasms - genetics
- Specialty
- Medical Oncology
- Molecular Medicine
- Abstract
- This volume focuses on the clinical applications of molecular diagnosis and targeted therapy from the viewpoint of oncologists specializing in specific organs. In addition, it discusses the role of molecular diagnosis and targeted therapy in the course of surgical treatment. Recent, rapid advances in molecular biology have shed new light on the mechanisms of cancer progression, and molecularly targeted drugs have been used to treat a variety of malignant diseases. For the diagnosis and precise treatment of cancer, analysis of the molecular background of the tumor is indispensable. However, there are both tumor-specific and comprehensive mechanisms involved in these processes. Accordingly, a firm grasp of molecular diagnosis and targeted therapies for different tumors is vital for clinicians and basic researchers alike. This book provides essential information and the latest findings on molecular diagnosis and targeted therapy for thoracic and gastrointestinal malignancies. Though primarily intended for clinical and basic oncologists, it also offers a useful guide for clinicians who are interested in this field and are considering getting started in molecular diagnosis and targeted therapy.
- Contents
- 1. Molecular biology of lung cancer in relation to precision medicine -- 2. Molecular diagnosis and targeting for breast cancer -- 3. Clinical application of stem cell biology in esophageal cancer -- 4. Molecular diagnosis and targeted therapy for gastric cancer -- 5. Molecular diagnosis and targeted therapy for colorectal cancer -- 6. Molecular and immunologic targets for the treatment of hepatocellular carcinoma -- 7. Molecular diagnosis and targeting for biliary tract cancer -- 8. Molecular analysis for therapeutic targets of pancreatic cancer -- 9. Molecular targeted therapy and diagnosis for gastroenteropancreatic neuroendocrine tumors.
- Format
- e-Book
- Location
- Online
Molecular Diagnostics in Cancer Patients
https://libcat.nshealth.ca/en/permalink/provcat44270
Kamla Kant Shukla, Praveen Sharma, Sanjeev Misra, editors.
--Singapore:
Springer
, 2019.
- Available Online
- View e-Book
- Location
- Online
This book aims to bring together a broad variety of examples of the role of pharmacogenomics in current drug development, uncovering dynamic concentration-dependent drug responses on biological systems to understand pharmacodynamics responses in human cancer where genetic lesions serve as tumor markers and provide a basis for cancer diagnosis. The book describes methods and protocols applied in molecular diagnostics. It offers pathologists and researchers providing molecular diagnostic services…
- Available Online
- View e-Book
- Other Authors
- Shukla, Kamla Kant
- Sharma, Praveen
- Misra, Sanjeev
- Responsibility
- Kamla Kant Shukla, Praveen Sharma, Sanjeev Misra, editors
- Place of Publication
- Singapore
- Publisher
- Springer
- Date of Publication
- 2019
- Physical Description
- 1 online resource (viii, 341 p.) : 45 illus., 43 illus. in color
- ISBN
- 9789811358777
- 9789811358760 (Print ed.)
- 9789811358784 (Print ed.)
- Subjects (MeSH)
- Biomarkers, Tumor
- Molecular Diagnostic Techniques
- Neoplasms - diagnosis
- Pharmacogenetics
- Specialty
- Medical Oncology
- Molecular Medicine
- Abstract
- This book aims to bring together a broad variety of examples of the role of pharmacogenomics in current drug development, uncovering dynamic concentration-dependent drug responses on biological systems to understand pharmacodynamics responses in human cancer where genetic lesions serve as tumor markers and provide a basis for cancer diagnosis. The book describes methods and protocols applied in molecular diagnostics. It offers pathologists and researchers providing molecular diagnostic services an array of the most recent and readily accessible reference to compare methods and techniques. Highlights include the molecular diagnosis of genetic aberrations by quantitative polymerase reaction (qPCR), sequence-specific oligonucleotide arrays, next-generation sequencing (NGS), CGH arrays-and methodologies directed at the detection of epigenetic events, high-throughput nucleic acid and protein arrays, direct sequencing and FISH-based methodologies, currently used in the diagnosis of solid tumors. The book also includes an innovative line of treatment in relation to the molecular prognosis, diagnosis and pharmacogenomics in the actual practice of clinical findings at molecular levels. The book covers the applications of numerous genetic testing methodologies; in approximately the chronological order of discovery and high-throughput diagnosis using advanced genomic approaches to identify such genes, in the search for novel drug targets and/or key determinants of drug reactions. It also promotes a wider understanding of molecular diagnostics among physicians, medical students, and scientists in academics, industry and corporate world.
- Contents
- 1. Recent Advances in Molecular Diagnostic Approaches for Cancer -- 2. Molecular Diagnosis of Gall Bladder Cancer -- 3. Molecular Diagnostics for Lung Cancer -- 4. Predicting E3 Ubiquitin Ligases as Possible Promising Biomarkers for Brain Tumors -- 5. Molecular Diagnostics in Melanoma: An Update -- 6. Molecular Diagnostics in Breast Cancer -- 7. Molecular Diagnostics in Non-Hodgkin Lymphoma -- 8. Molecular Diagnosis of Cervical Cancer -- 9. Molecular Diagnostics in Colorectal Cancer -- 10. Molecular Diagnostics in Pancreatic Cancer -- 11. Molecular Diagnostics in Head and Neck Squamous Cell Carcinoma -- 12. Molecular Diagnostic in Prostate Cancer -- 13. Molecular Diagnostics in Renal Cancer -- 14. Molecular Biomarkers and Urinary Bladder Cancer (UBC) -- 15. Molecular Pathway and Fluorescence In Situ Hybridization Testing of ERBB2 (HER2) Gene Amplification in Invasive Ductal Carcinoma of Breast -- 16. Exploring Potential of RPPA Technique in Oral Cancer Biomarker Discovery Research -- 17. Molecular Diagnostics in Liver Cancer -- 18. Molecular Diagnosis of Uterine Cancer -- 19. Molecular Diagnosis in Ovarian Carcinoma.
- Format
- e-Book
- Location
- Online
Molecular pharmacology
https://libcat.nshealth.ca/en/permalink/provcat18958
American Society for Pharmacology and Experimental Therapeutics
- Available Online
- View e-Journal
- Holdings
- Vol 51, 1997 - (delayed 12 months)
- Location
- Online
- Available Online
- View e-Journal
- Publisher
- American Society for Pharmacology and Experimental Therapeutics
- Holdings
- Vol 51, 1997 - (delayed 12 months)
- Publication Frequency
- Monthly
- ISSN
- 1521-0111
- Specialty
- Molecular Medicine
- Pharmacology
- Format
- e-Journal
- Location
- Online
Molecular Targeted Radiosensitizers : Opportunities and Challenges
https://libcat.nshealth.ca/en/permalink/provcat45329
Henning Willers, Iris Eke, editors.
--Cham:
Humana Press
, c2020.
- Available Online
- View e-Book
- Location
- Online
Molecular Targeted Radiosensitizers: Opportunities and Challenges provides the reader with a comprehensive review of key pre-clinical research components required to identify effective radiosensitizing drugs. The book features discussions on the mechanisms and markers of clinical radioresistance, pre-clinical screening of targeted radiosensitizers, 3D radiation biology for studying radiosensitizers, in vivo determinations of local tumor control, genetically engineered mouse models for studying …
- Available Online
- View e-Book
- Other Authors
- Willers, Henning
- Eke, Iris
- Responsibility
- Henning Willers, Iris Eke, editors
- Place of Publication
- Cham
- Publisher
- Humana Press
- Date of Publication
- c2020
- Physical Description
- 1 online resource (xi, 364 p.) : 42 illus., 38 illus. in color
- Series Title
- Cancer drug discovery and development
- ISBN
- 9783030497019
- 9783030497002 (Print ed.)
- 9783030497026 (Print ed.)
- 9783030497033 (Print ed.)
- ISSN
- 2196-9906
- Subjects (MeSH)
- Molecular Medicine
- Neoplasms - radiotherapy
- Radiation-Sensitizing Agents
- Radiotherapy - methods
- Specialty
- Medical Oncology
- Pharmacology
- Radiotherapy
- Abstract
- Molecular Targeted Radiosensitizers: Opportunities and Challenges provides the reader with a comprehensive review of key pre-clinical research components required to identify effective radiosensitizing drugs. The book features discussions on the mechanisms and markers of clinical radioresistance, pre-clinical screening of targeted radiosensitizers, 3D radiation biology for studying radiosensitizers, in vivo determinations of local tumor control, genetically engineered mouse models for studying radiosensitizers, targeting the DNA damage response for radiosensitization, targeting tumor metabolism to overcome radioresistance, radiosensitizers in the era of immuno-oncology, and more. Additionally, the book features discussions on high-throughput drug screening, predictive biomarkers, pre-clinical tumor models, and the influence of the tumor microenvironment and the immune system, with a specific focus on the challenges radiation oncologists and medical oncologists currently face in testing radiosensitizers in human cancers. Edited by two acclaimed experts in radiation biology and radiosensitizers, with thirteen chapters contributed by experts, this new volume presents an in-depth look at current developments within a rapidly moving field, with a look at where the field will be heading and providing comprehensive insight into the framework of targeted radiosensitzer development. Essential reading for investigators in cancer research and radiation biology.
- Contents
- Introduction to Molecular Targeted Radiosensitizers: Opportunities and Challenges -- Translating Targeted Radiosensitizers into the Clinic -- Mapping the Radiogenome of Human Cancers -- Mechanisms and Markers of Clinical Radioresistance -- Preclinical Strategies for Testing of Targeted Radiosensitizers -- 3D Radiation Biology for Identifying Radiosensitizers -- Preclinical In Vivo Evaluation of Novel Radiosensitizers by Local Tumor Control Experiments -- Genetically Engineered Mouse Models for Studying Radiation Biology and Radiosensitizers -- Targeting the DNA Damage Response for Radiosensitization -- Targeting Tumor Metabolism to Overcome Radioresistance -- Targeting Tumor Hypoxia -- Normalizing the Tumor Microenvironment for Radiosensitization -- Radiosensitizers in the Era of Immuno-Oncology.
- Format
- e-Book
- Location
- Online
NAFLD and NASH : Biomarkers in Detection, Diagnosis and Monitoring
https://libcat.nshealth.ca/en/permalink/provcat45509
Manuel Romero-Gomez, editor.
--Cham:
Springer
, c2020.
- Available Online
- View e-Book
- Location
- Online
This book provides a comprehensive overview of the diagnosis and management of Non-alcoholic Fatty Liver Disease (NAFLD) and Non-Alcoholic Steatohepatis (NASH). Basic principles of disease progression, the genetic and nutritional basis of NAFLD and NASH are explained along with the proteomic principles underlying biomarker development. Chapters cover both biochemical and imaging biomarkers used in elastrography and ultrasound and discuss how these are applicable to early diagnosis and monitorin…
- Available Online
- View e-Book
- Other Authors
- Romero-Gomez, Manuel
- Responsibility
- Manuel Romero-Gomez, editor
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2020
- Physical Description
- 1 online resource (x, 236 p.) : 18 illus., 17 illus. in color
- ISBN
- 9783030371739
- 9783030371722 (Print ed.)
- 9783030371746 (Print ed.)
- 9783030371753 (Print ed.)
- Subjects (MeSH)
- Biomarkers - analysis
- Diagnostic Techniques and Procedures
- Fatty Liver - diagnosis
- Non-alcoholic Fatty Liver Disease - diagnosis
- Specialty
- Diagnosis
- Gastroenterology
- Molecular Medicine
- Abstract
- This book provides a comprehensive overview of the diagnosis and management of Non-alcoholic Fatty Liver Disease (NAFLD) and Non-Alcoholic Steatohepatis (NASH). Basic principles of disease progression, the genetic and nutritional basis of NAFLD and NASH are explained along with the proteomic principles underlying biomarker development. Chapters cover both biochemical and imaging biomarkers used in elastrography and ultrasound and discuss how these are applicable to early diagnosis and monitoring of NASH and NAFLD. This is a useful resource for hepatologists, primary care providers with an interest in metabolic disease, diabetologists and endocrinologists in their daily clinical practice.
- Contents
- 1. The Spectrum of NAFLD: From the Organ to the System -- 2. Detection of NAFLD/NASH in the General Population and in Primary Care Clinics -- 3. Genes and NAFLD/NASH Progression -- 4. Geometry of Nutrition: Nutrients and NAFLD Progression -- 5. Biomarkers in Pediatric NAFLD -- 6. Biochemical Biomarkers of NAFLD/NASH -- 7. Non-invasive Assessment of Non-alcoholic Fatty Liver Disease: Ultrasound and Transient Elastography -- 8. MR Based-Imaging Biomarkers in NAFLD/NASH -- 9. Extracellular Vesicles in Non-alcoholic Fatty Liver Disease: Key Players in Disease Pathogenesis and Promising Biomarker Tools -- 10. From Transcriptomic to Metabolomic in the Development of Biomarkers in NAFLD/NASH -- 11. HCC in Patients with NAFLD/NASH -- 12. Psychological Biomarker Profile in NAFLD/NASH with Advanced Fibrosis -- 13. Integrative Proposal for the Use of Biomarkers in Clinical Practice Management of NAFLD/NASH.
- Format
- e-Book
- Location
- Online
