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Bone-implant interface in orthopedic surgery : basic science to clinical applications

https://libcat.nshealth.ca/en/permalink/provcat33691
Theofilos Karachalios, editor. --London: Springer , c2014.
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What is the optimal design and fixation of the implants we use for orthopedic reconstructions? What is the gold standard for the management of patients requiring implants? Is there scope for improvement still further? Huge efforts have been made both by research scientists in orthopedics and the implant industry to furthering the options available for arthroplasty without necessarily considering the cost-effectiveness of this research to clinical outcomes. It has also become apparent that theor…
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Other Authors
Karachalios, Theofilos
Responsibility
Theofilos Karachalios, editor
Place of Publication
London
Publisher
Springer
Date of Publication
c2014
Physical Description
1 online resource (xi, 342 pages)
ISBN
9781447154099 (electronic bk.)
9781447154082
Subjects (MeSH)
Arthroplasty, Replacement
Bone and Bones
Joint Prosthesis
Prosthesis Implantation
Subjects (LCSH)
Artificial joints
Joints - Endoscopic surgery
Joints - surgery
Endoscopy
Prostheses and Implants
Surgical Orthopedics
Molecular Medicine
Abstract
What is the optimal design and fixation of the implants we use for orthopedic reconstructions? What is the gold standard for the management of patients requiring implants? Is there scope for improvement still further? Huge efforts have been made both by research scientists in orthopedics and the implant industry to furthering the options available for arthroplasty without necessarily considering the cost-effectiveness of this research to clinical outcomes. It has also become apparent that theoretical and laboratory studies do not always match the results of long-term clinical studies of which there regretfully few of sufficient quality. The Editor and his carefully chosen selection of contributors critically evaluate data from basic science, experimental in vivo and in vitro biological and mechanical models, autopsy specimens and long-term clinical studies to answer these questions. Bone-Implant Interface in Orthopedic Surgery: Basic Science to Clinical Applications focuses on the bone-orthopedic implant interface in general and will be useful both for the novice who seeks a quick introduction to this specific topic and for more experienced surgeons who seek an in depth critical review of current practices.
Contents
Current evidence in designs and fixation surfaces in total hip arthroplasty -- Early and late mechanical stability of the cementless bone-implant interface in total joint arthroplasty -- Bone-cement interface in total joint arthroplasty -- The implant-cement interface in total hip arthroplasty -- Cobalt-chrome porous coated implant-bone interface in total joint arthroplasty -- Titanium porous-coated implant-bone interface in total joint arthroplasty -- Grit-blasted implant bone interface in total joint arthroplasty -- HA coated implant: bone interface in total joint arthroplasty -- Trabecular metal: bone interface in total joint arthroplasty -- Assessment of a failed (painful?) total joint arthroplasty -- The biology of aseptic loosening -- Cement-bone interface in revision arthroplasty -- Cementless fully porous-coated implant-bone interface in revision total hip arthroplasty -- Cementless tapered fluted implant-bone interface in revision total joint arthroplasty -- Bone-graft and implant-graft interface in total hip arthroplasty -- The effect of pharmacological agents on the bone implant interface -- Bone-implant interface in biofilm-associated bone and joint infections -- Modular interfaces -- Local and distant reaction to metallic wear debris -- Bone-implant interface in spine surgery -- Bone-tendon and bone-ligament interface -- Bone-implant interface in patients with neoplasmatic disease.
Format
e-Book
Location
Online
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Cellular and Molecular Basis of Mitochondrial Inheritance : Mitochondrial Disease and Fitness

https://libcat.nshealth.ca/en/permalink/provcat44497
Peter Sutovsky, editor. --Cham: Springer , c2019.
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This new volume of our successful book series Advances in Anatomy, Embryology and Cell Biology is focused on mitochondrial inheritance in humans and both vertebrate and invertrebate animals including Drosophila, C. elegans, bivalve molusc Mytilus and livestock mammals. Special consideration is given to cellular mechanisms promoting uniparental inheritance of mitochondria and mitochondrial genes, evolutionary perspectives, and biomedical and epidemiological considerations. Contributed by five di…
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Other Authors
Sutovsky, Peter
Responsibility
Peter Sutovsky, editor
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2019
Physical Description
1 online resource (xi, 126 p.) : 28 illus., 24 illus. in color
Series Vol.
231
Series Title
Advances in anatomy, embryology and cell biology
ISBN
9783030045708
9783030045692 (Print ed.)
9783030045715 (Print ed.)
ISSN
0301-5556
Subjects (MeSH)
DNA, Mitochondrial
Extrachromosomal Inheritance
Genes, Mitochondrial
Mitochondria - genetics
Specialty
Cell Biology
Genetics, Medical
Molecular Medicine
Abstract
This new volume of our successful book series Advances in Anatomy, Embryology and Cell Biology is focused on mitochondrial inheritance in humans and both vertebrate and invertrebate animals including Drosophila, C. elegans, bivalve molusc Mytilus and livestock mammals. Special consideration is given to cellular mechanisms promoting uniparental inheritance of mitochondria and mitochondrial genes, evolutionary perspectives, and biomedical and epidemiological considerations. Contributed by five distinguished mitochondrial research teams from around the world, this volume will target a wide audience of physiologists, anatomists, cell, and developmental and evolutionary biologists, as well as physicians, veterinarians, livestock specialists and biomedical researchers.
Contents
Autophagosomal Sperm Organelle Clearance and mtDNA Inheritance in C. elegans -- Doubly Uniparental Inheritance of mtDNA: An Unappreciated Defiance of a General Rule -- Exogenous Factors May Differentially Influence the Selective Costs of mtDNA Mutations -- Transmission of Dysfunctional Mitochondrial DNA and Its Implications for Mammalian Reproduction -- Mitochondria Inspire a Lifestyle.
Format
e-Book
Location
Online
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Cellular and molecular immunology

https://libcat.nshealth.ca/en/permalink/provcat33146
editors Abul K. Abbas, Andrew H. Lichtman, Shiv Pillai ; illustrations by David L. Baker. (10th ed.) --Philadelphia, PA: Elsevier , c2022.
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Well-written, readable, and superbly illustrated, Cellular and Molecular Immunology, 10th Edition, continues the tradition of excellence established through multiple editions of this bestselling text. Offering an unparalleled introduction to this complex field, it retains a practical, clinical focus while updating and revising all content to ensure clarity and comprehension, bringing readers fully up to date with new and emerging information in this challenging area.
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Other Authors
Abbas, Abul K.
Lichtman, Andrew H.
Pillai, Shiv
Responsibility
editors Abul K. Abbas, Andrew H. Lichtman, Shiv Pillai ; illustrations by David L. Baker
Edition
10th ed.
Place of Publication
Philadelphia, PA
Publisher
Elsevier
Date of Publication
c2022
Physical Description
1 online resource, 600 p.
ISBN
9780323757485
Subjects (MeSH)
Immunity, Cellular
Antibody Formation - immunology
Antigens - immunology
Immune System Diseases - immunology
Lymphocytes - immunology
Subjects (LCSH)
Immunity, Cellular
Antibody Formation - immunology
Antigens - immunology
Immune System Diseases - immunology
Lymphocytes - immunology
Cellular immunity
Molecular immunology
Specialty
Allergy and Immunology
Cell Biology
Molecular Medicine
Abstract
Well-written, readable, and superbly illustrated, Cellular and Molecular Immunology, 10th Edition, continues the tradition of excellence established through multiple editions of this bestselling text. Offering an unparalleled introduction to this complex field, it retains a practical, clinical focus while updating and revising all content to ensure clarity and comprehension, bringing readers fully up to date with new and emerging information in this challenging area.
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Location
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Clinical Molecular Diagnostics

https://libcat.nshealth.ca/en/permalink/provcat46964
Shiyang Pan, Jinhai Tang. Springer , 2021.
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Online
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Responsibility
Shiyang Pan, Jinhai Tang
Publisher
Springer
Date of Publication
2021
Physical Description
1 online resource (xxviii, 889 pages) : illustrations
ISBN
9789811610370
Specialty
Diagnosis
Molecular Medicine
Format
e-Book
Location
Online
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Damage-Associated Molecular Patterns in Human Diseases : Volume 1. Injury-Induced Innate Immune Responses

https://libcat.nshealth.ca/en/permalink/provcat42536
Walter Gottlieb Land. --Cham: Springer , c2018.
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This book presents current understanding of the importance of modern immunology in the etiopathogenesis of human diseases and explores how this understanding is impacting on diagnosis, prognosis, treatment, and prophylaxis. As the core of modern immunology, the "danger/injury model" is introduced and addressed throughout the book. Volume I of the book describes the network of damage-associated molecular pattern molecules (DAMPs) and examines the central role of DAMPs in cellular stress response…
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Author
Land, Walter Gottlieb
Responsibility
Walter Gottlieb Land
Alternate Title
Injury-induced innate immune responses
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2018
Physical Description
1 online resource (xlviii, 870 p.) : 115 illus., 102 illus. in color
ISBN
9783319786551
9783319786544 (print ed.)
9783319786568 (print ed.)
Subjects (MeSH)
Biomarkers - analysis
Immunologic Techniques
Molecular Medicine
Pathogen-Associated Molecular Pattern Molecules
Stress, Physiological - immunology
Wounds and Injuries - immunology
Specialty
Diagnosis
Molecular Medicine
Pathology
Abstract
This book presents current understanding of the importance of modern immunology in the etiopathogenesis of human diseases and explores how this understanding is impacting on diagnosis, prognosis, treatment, and prophylaxis. As the core of modern immunology, the "danger/injury model" is introduced and addressed throughout the book. Volume I of the book describes the network of damage-associated molecular pattern molecules (DAMPs) and examines the central role of DAMPs in cellular stress responses and associated regulated cell death, the promotion and resolution of inflammation, the activation of innate lymphoid cells and unconventional T cells, the stimulation of adaptive immunity, and tissue repair. The significance of DAMPs in a wide range of human diseases will then be explored in Volume II of the book, with discussion of the implications of injury-induced innate immunity for present and future treatments. This book is written for professionals from all medical and paramedical disciplines who are interested in the introduction of innovative data from immunity and inflammation research into clinical practice. The readership will include practitioners and clinicians such as hematologists, rheumatologists, traumatologists, oncologists, intensive care anesthetists, endocrinologists such as diabetologists, psychiatrists, neurologists, pharmacists, and transplantologists.
Contents
Part I. The Three Major Paradigms in Modern Immunology -- Prologue: The Term "Immunity" over the Course of Time -- The Three Major Paradigms in Immunology -- Epilogue: What Major Paradigm in Immunology Comes Next? -- Part II. The Innate Immune System: an Organ of Perception Determined to Maintain Homeostasis -- Prologue: The Guardians of Homeostasis -- Innate Immune Recognition Molecules -- Epilogue: The Innate Immune System: a Global Player in Health and Disease -- Part III. The Whole Family of Mammalian Innate Immune Cells -- Prologue: The Whole Body as an Immune System? -- Mobile Innate Immune Cells -- Sessile Innate Immune Cells -- Epilogue: The Whole Body as an Immune Defence System -- Part IV. The World of DAMPs. Prologue: About DAMPs, PAMPs and MAMPs -- Endogenous DAMPs, Category I: Constitutively Expressed Native Molecules (Cat. I DAMPs) -- Endogenous DAMPs, Category II: Constitutively Expressed, Injury-Modified Molecules (Cat. II DAMPs) -- Endogenous DAMPs, Category III: Inducible DAMPs (Cat. III DAMPs) -- Exogenous DAMPs, Category IV (Cat. IV DAMPs) -- Epilogue: The Well-Dosed Work of DAMPs in their Commission to Restore and Maintain Homeostasis -- Part V. Cellular Stress Responses and Regulated Cell Death -- Prologue: Innate Immune Tools to Defend against Stressful Injury: Success and Failure -- Cell-Autonomous (Cell-Intrinsic) Stress Responses -- Regulated Cell Death -- Epilogue: The Horror of an Injury-Induced Avalanche of DAMPs -- Part VI. Innate Immune Effector Responses -- Prologue: The Various Facets of Innate Immune Effector Responses -- Cellular Inflammatory Responses -- Humoral Innate Immune Effector Responses -- Regulation of Innate Inflammatory Responses -- Epilogue to Part VI -- Part VII. Function of Innate Lymphoid Cells and Unconventional T Cells with Partial Innate Function -- Prologue: The "Ready-to-Go" Lymphocytes of the Immune System -- Activating and Function of Innate Lymphoid Cells -- Activating and Function of Unconventional T Cells -- Epilogue: Killer Lymphocytes as Tools for Future Immunotherapeutic Approaches -- Part VIII. DAMPs Promoting Adaptive Immunity and Tissue Repair -- Prologue: The "Long Arm" of DAMPs in Shaping Adaptive Immune Responses and Tissue Repairing Processes -- Antigen Uptake, Processing and Presentation by Dendritic Cells -- Antigen in the Presence of DAMPs Induces Immunostimulatory Dendritic Cells to Promote "Destructive" Acquired Immune Responses -- Antigen in the Absence of DAMPs Promotes Immunotolerance: the Role of Dendritic Cells and Regulatory T Cells -- An Impressive Example of Peripheral Tolerance against Nonself: Tolerance to Commensal Bacterial and Dietary Protein Antigens -- Immunometabolism of Dendritic Cells and T Cells -- Role of DAMPs in Tissue Regeneration and Repair -- Epilogue: DAMPs as Key Players in the Pathogenesis of Many Human Diseases.
Format
e-Book
Location
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Damage-Associated Molecular Patterns in Human Diseases : Volume 2: Danger Signals as Diagnostics, Prognostics, and Therapeutic Targets

https://libcat.nshealth.ca/en/permalink/provcat45638
Walter Gottlieb Land. --Cham: Springer , c2020.
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This book is a continuance of the topic: “DAMPs in Human Diseases”, the basics of which were described in a first volume by the same author. This second volume presents our current understanding of the impact of sterile stress/injury-induced innate immune responses on the etiopathogenesis of human diseases by focusing on those diseases that are pathogenetically dominated by DAMPs, i.e., on polytrauma, various solid organ injuries (brain, lung, kidney, liver), atherosclerosis, and cerebro-cardio…
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Author
Land, Walter Gottlieb
Responsibility
Walter Gottlieb Land
Alternate Title
Danger signals as diagnostics, prognostics, and therapeutic targets
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2020
Physical Description
1 online resource (xxxix, 629 p.) : 45 illus. in color
ISBN
9783030538682
9783030538675 (Print ed.)
9783030538699 (Print ed.)
9783030538705 (Print ed.)
Subjects (MeSH)
Biomarkers
Immunologic Techniques
Molecular Medicine
Pathogen-Associated Molecular Pattern Molecules
Stress, Physiological - immunology
Wounds and Injuries - immunology
Specialty
Diagnosis
Molecular Medicine
Pathology
Abstract
This book is a continuance of the topic: “DAMPs in Human Diseases”, the basics of which were described in a first volume by the same author. This second volume presents our current understanding of the impact of sterile stress/injury-induced innate immune responses on the etiopathogenesis of human diseases by focusing on those diseases that are pathogenetically dominated by DAMPs, i.e., on polytrauma, various solid organ injuries (brain, lung, kidney, liver), atherosclerosis, and cerebro-cardiovascular diseases. Our growing understanding of the pathogenetic function of activating DAMPs and suppressive DAMPs (“SAMPs”) is used as a point of departure to explore how these molecules can be used as biomarkers to extend and improve current diagnostic and prognostic modalities. Moreover, this new knowledge about the pathogenetic function of DAMPs and SAMPs is taken as a sound and plausible reason for discussing their implications for present and future treatment of the diseases addressed here. In this context, the focus is on the potential of DAMPs as future therapeutic targets and SAMPs as future therapeutics, applied in strict compliance with safety precautions, as also recommended in this work. The book is intended for professionals from all medical and paramedical disciplines who are interested in applying innovative data from inflammation and immunity research to clinical practice. The readership will include practitioners and clinicians working in the broad field of acute and chronic inflammatory/fibrotic diseases, in particular, traumatologists and intensivists; neurologists and neurosurgeons; cardiologists and cardiac surgeons; pulmonologists and thoracic surgeons; vascular surgeons; nephrologists; gastroenterologists and hepatologists; and pharmacists. Also available: Damage-Associated Molecular Patterns in Human Diseases, Vol. 1: Injury-Induced Innate Immune Responses.
Contents
Part I. Prologue -- Perspectives of the Danger/Injury Model in Immunology -- Part II. A Select, Clinically Oriented Update of Topics Presented in “Damage-Associated Molecular Patterns in Human Diseases, Volume 1: Injury-Induced Innate Immune Responses" -- Pattern Recognition Molecules -- The Growing World of DAMPs -- The Growing Clinical Relevance of Cellular Stress Responses and Regulated Cell Death -- DAMP-Promoted Efferent Innate Immune Responses in Human Diseases: Inflammation -- DAMP-Promoted Efferent Innate Immune Responses in Human Diseases: Fibrosis -- Part III. DAMPs and SAMPs in Traumatic Disorders, Atherosclerosis, and Cerebro-Cardiovascular Diseases -- DAMPs and SAMPs as Molecular Biomarkers, Therapeutic Targets, and Therapeutics -- DAMP-Controlled and Uncontrolled Responses to Trauma: Wound Healing and Polytrauma -- Solid Organ Injury -- Atherosclerosis -- Cerebro - Cardiovascular Diseases -- Part IV. Epilogue -- The “DAMPome” as a Key Player in the Pathogenesis of Human Diseases.
Format
e-Book
Location
Online
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Hepatitis C viruses : genomes and molecular biology

https://libcat.nshealth.ca/en/permalink/provcat23039
Tan, Seng-Lai. --Wymondham, Norfolk, UK: Horizon Bioscience , 2006.
Call Number
QW 170 H529 2006
Location
Dickson Building
Call Number
QW 170 H529 2006
Author
Tan, Seng-Lai
Place of Publication
Wymondham, Norfolk, UK
Publisher
Horizon Bioscience
Date of Publication
2006
Physical Description
469 p.
ISBN
1904933203
Subjects (MeSH)
Hepacivirus - genetics
Genomics
Molecular Biology
Specialty
Genetics, Medical
Molecular Medicine
Virology
Format
Book
Location
Dickson Building
Loan Period
3 weeks
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Imaging and Metabolism

https://libcat.nshealth.ca/en/permalink/provcat43247
Jason S. Lewis, Kayvan R. Keshari, editors. --Cham: Springer , c2018.
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Location
Online
This book presents advanced molecular imaging techniques used to assess metabolic function. Covering state-of-the art modalities, it discusses the evaluation of a wide range of diseases that have a metabolic component, including cancer, inflammatory conditions, diabetes, neurodegeneration, and cardiovascular disorders. Imaging provides a quantitative perspective to the assessment of metabolic function and complements genetic analysis of disorders related to disrupted metabolism. Organized into …
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Other Authors
Lewis, Jason S.
Keshari, Kayvan R.
Responsibility
Jason S. Lewis, Kayvan R. Keshari, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2018
Physical Description
1 online resource (xiii, 331 p.) : 195 illus., 165 illus. in color
ISBN
9783319614014
9783319613994 (print ed.)
9783319614007 (print ed.)
9783319870731 (print ed.)
Subjects (MeSH)
Biomarkers - metabolism
Metabolic Diseases - diagnostic imaging
Metabolomics
Molecular Imaging - methods
Specialty
Diagnostic Imaging
Molecular Medicine
Abstract
This book presents advanced molecular imaging techniques used to assess metabolic function. Covering state-of-the art modalities, it discusses the evaluation of a wide range of diseases that have a metabolic component, including cancer, inflammatory conditions, diabetes, neurodegeneration, and cardiovascular disorders. Imaging provides a quantitative perspective to the assessment of metabolic function and complements genetic analysis of disorders related to disrupted metabolism. Organized into four parts, the book highlights basic principles in molecular imaging techniques; metabolic imaging approaches, including magnetic resonance imaging (MRI), single-photon emission computed tomography (SPECT), positron emission tomography (PET), and hybrid modalities; metabolic diseases; and future perspectives. Featuring contributions from leading authorities in radiology, oncology, cardiology, and neurology, Imaging and Metabolism is a pioneering exploration of the role of imaging modalities in assessing the physiological status of abnormal cells and diagnosing disease.
Contents
Part I. Basic Principles -- 1. Molecular Imaging and Molecular Imaging Technologies -- 2. A Topical Report on the Design Principles of Metabolism -- Part II. Metabolic Imaging Approaches -- 3. Overview of Positron-Emission Tomography Tracers for Metabolic Imaging -- 4. Introduction: MRI/MRS as Metabolic Imaging Tools -- 5. Metabolic Imaging Approaches: Optical Imaging -- Part III. Metabolic Diseases -- 6. Cancer Metabolism -- 7. Inflammation and Immune Metabolism -- 8. Imaging in Diabetes -- 9. Brain Disorders -- 10. Fatty Liver Disease -- 11. Imaging Myocardial Metabolism -- 12. Other Metabolic Syndromes.
Format
e-Book
Location
Online
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Anne C. Chiang, Roy S. Herbst. Humana , 2021.
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Location
Online
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Responsibility
Anne C. Chiang, Roy S. Herbst
Publisher
Humana
Date of Publication
2021
Physical Description
1 online resource (vi, 264 pages) : illustrations
Series Title
Current cancer research
ISBN
9783030740283
Specialty
Medical Oncology
Research
Molecular Medicine
Format
e-Book
Location
Online
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Molecular Applications in Cytology

https://libcat.nshealth.ca/en/permalink/provcat42591
Fernando C. Schmitt, editor. --Cham: Springer , c2018.
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Online
This book is intended for practicing pathologists and cytopathologists, as well as for pathology trainees and cytotechnicians. It starts with a detailed description of the extremely important pre-analytical phase for molecular testing followed by a presentation of the key tests and their application in different organs, e.g. the lung or thyroid. Step-by-step instructions for the different assays, reporting and clinical integration of the test results are discussed. The authors help the reader t…
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Other Authors
Schmitt, Fernando C.
Responsibility
Fernando C. Schmitt, editor
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2018
Physical Description
1 online resource (viii, 268 p.) : 61 illus., 60 illus. in color
ISBN
9783319749426
9783319749402 (print ed.)
9783319749419 (print ed.)
Subjects (MeSH)
Cytological Techniques
Molecular Medicine
Specialty
Cell Biology
Molecular Medicine
Abstract
This book is intended for practicing pathologists and cytopathologists, as well as for pathology trainees and cytotechnicians. It starts with a detailed description of the extremely important pre-analytical phase for molecular testing followed by a presentation of the key tests and their application in different organs, e.g. the lung or thyroid. Step-by-step instructions for the different assays, reporting and clinical integration of the test results are discussed. The authors help the reader to benefit from their experiences by providing a valuable tool for the implementation of these techniques in daily practice. Though the use of molecular techniques is well established in surgical biopsies, to date they are not widely used in connection with cytological material. However, in some fields like lung cancer or aspirates from the pancreas and biliary tract the only available material for diagnosis is the cytological preparation a fact that has created a need for the standardization of molecular techniques on cytology.
Contents
Why Cytology for Molecular Testing? Pros and Cons -- How to Prepare Cytological Samples for Molecular Testing -- Molecular Tests Use in Cytological Material (Analytical Phase) -- Molecular Cytology Applications on Head and Neck -- Molecular Cytology Applications on Lung -- Molecular Cytology of Serous Effusions -- Molecular Cytology Applications on Urine -- Molecular Cytology Applications on Gynecological Cytology -- Molecular Applications in Hematolymphoid Cytology -- Molecular Cytology Application on Thyroid -- Molecular Cytology Applications on Pancreas and Biliary Tract -- Molecular Cytology Applications in Soft Tissue (Pediatric tumors) -- Molecular Cytology Applications in Metastases -- Clinical Integration of Molecular Results on Cytology (Post-analytical Phase).
Format
e-Book
Location
Online
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Molecular biology

https://libcat.nshealth.ca/en/permalink/provcat32198
David P. Clark, Nanette Jean Pazdernik, Michelle R. McGehee. (3rd ed.) --London, UK: Elsevier , c2019.
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Molecular Biology, Third Edition, provides a thoroughly revised, invaluable resource for college and university students in the life sciences, medicine and related fields. This esteemed text continues to meet the needs of students and professors by offering new chapters on RNA, genome defense, and epigenetics, along with expanded coverage of RNAi, CRISPR, and more ensuring topical content for a new class of students. This volume effectively introduces basic concepts that are followed by more s…
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Author
Clark, David P.
Other Authors
Pazdernik, Nanette Jean
Responsibility
David P. Clark, Nanette Jean Pazdernik, Michelle R. McGehee
Edition
3rd ed.
Place of Publication
London, UK
Publisher
Elsevier
Date of Publication
c2019
Physical Description
1 online resource, 1006 p.
ISBN
9780128132883
Subjects (MeSH)
Cell Physiological Phenomena - genetics
Genetic phenomena
Molecular Biology - methods
Subjects (LCSH)
Molecular biology
Molecular genetics
Cell Physiological Phenomena - genetics
Genetic Phenomena
Molecular Biology - methods
Genetics
Specialty
Cell Biology
Molecular Medicine
Abstract
Molecular Biology, Third Edition, provides a thoroughly revised, invaluable resource for college and university students in the life sciences, medicine and related fields. This esteemed text continues to meet the needs of students and professors by offering new chapters on RNA, genome defense, and epigenetics, along with expanded coverage of RNAi, CRISPR, and more ensuring topical content for a new class of students. This volume effectively introduces basic concepts that are followed by more specific applications as the text evolves.
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Format
e-Book
Location
Online
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Molecular cancer

https://libcat.nshealth.ca/en/permalink/provcat16226
BioMed Central
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Holdings
Vol 1, 2002 -
Location
Online
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Publisher
BioMed Central
Holdings
Vol 1, 2002 -
ISSN
1476-4598
Specialty
Medical Oncology
Molecular Medicine
Format
e-Journal
Location
Online
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Molecular cancer research

https://libcat.nshealth.ca/en/permalink/provcat16231
AACR Press
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Holdings
Vol 1, 2002 -
Location
Online
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Continues
Cell growth and differentiation
Publisher
AACR Press
Holdings
Vol 1, 2002 -
ISSN
1541-7786
Specialty
Medical Oncology
Molecular Medicine
Format
e-Journal
Location
Online
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Molecular cancer therapeutics

https://libcat.nshealth.ca/en/permalink/provcat16230
AACR Press
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Holdings
Vol 1, 2001 -
Location
Online
Available Online
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Publisher
AACR Press
Holdings
Vol 1, 2001 -
ISSN
1535-7163
Specialty
Medical Oncology
Molecular Medicine
Format
e-Journal
Location
Online
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Molecular Determinants of Head and Neck Cancer

https://libcat.nshealth.ca/en/permalink/provcat42783
Barbara Burtness, Erica A. Golemis, editors. (Second edition) --Cham: Humana Press , c2018.
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Squamous cell cancers of the head and neck (SCCHN), also known as head and neck cancers (HNC) encompass malignancies of the oral cavity, larynx, nasopharynx and pharynx, and are diagnosed in over 500,000 patients worldwide each year, accounting for 5% of all malignancies. It is estimated that approximately 50,000 patients develop head and neck cancer annually in the United States, of whom approximately 50% succumb to this cancer. For most cases of SCCHN, treatment is multimodal, often combining…
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Other Authors
Burtness, Barbara
Golemis, Erica A.
Responsibility
Barbara Burtness, Erica A. Golemis, editors
Edition
Second edition
Place of Publication
Cham
Publisher
Humana Press
Date of Publication
c2018
Physical Description
1 online resource (vi, 629 p.) : 68 illus., 62 illus. in color
Series Title
Current cancer research
ISBN
9783319787626
9783319787619 (print ed.)
9783319787633 (print ed.)
ISSN
2199-2584
Subjects (MeSH)
Head and Neck Neoplasms - etiology
Head and Neck Neoplasms - genetics
Head and Neck Neoplasms - therapy
Specialty
Medical Oncology
Molecular Medicine
Abstract
Squamous cell cancers of the head and neck (SCCHN), also known as head and neck cancers (HNC) encompass malignancies of the oral cavity, larynx, nasopharynx and pharynx, and are diagnosed in over 500,000 patients worldwide each year, accounting for 5% of all malignancies. It is estimated that approximately 50,000 patients develop head and neck cancer annually in the United States, of whom approximately 50% succumb to this cancer. For most cases of SCCHN, treatment is multimodal, often combining surgery or irradiation with chemotherapy; even successfully treated patients frequently experience durable and severe side effects. Improving cure rates and reducing chronic morbidity are urgent clinical needs for head and neck cancer. However, in contrast to cancer types such as breast or prostate that have been much studied and have well-defined biology, until recently, relatively few researchers investigated the molecular basis of HNC, making it difficult to design targeted treatments with better efficacy and less debilitating side effects. This volume will provide an overview of the factors contributing to disease pathogenesis, including the recognition of discrete molecular subtypes with distinct etiology, prognosis, and treatment response. This volume will familiarize the reader with the critical signaling pathways and oncogenic drivers for HNC. It will outline the differences between HPV-positive and HPV-negative disease, and how these differences affect treatment choice and outcome. The book will emphasize developments in the past five years, including the growing understanding of the genomic and epigenomic features of the disease based on analysis of next generation sequencing (NGS) data, and timely topics such as the analysis of HNC stem cell populations, non-coding mRNAs, and inflammatory response. It will address exciting new therapeutic approaches such as the use of immunotherapies to treat HNC patients. Overall, the book will provide the reader with current understanding of the biology and treatment of the disease, and describe timely questions that will guide future research aimed at controlling and curing this disease.
Contents
1. Overview: The Pathobiology of Head and Neck Cancer -- 2. Targeting the ErbB Family in Head and Neck Cancer -- 3. c-MET in Head and Neck Squamous Cell Carcinoma -- 4. Transforming Growth Factor Beta (TGF-ß) Signaling in Head and Neck Squamous Cell Carcinoma (HNSCC) -- 5. The PI3K Signaling Pathway in Head and Neck Squamous Cell Carcinoma -- 6. Jak/STAT Signaling in Head and Neck Cancer -- 7. Molecular Regulation of Cell Cycle and Cell Cycle-Targeted Therapies in Head and Neck Squamous Cell Carcinoma (HNSCC -- 8. Role of the NOTCH Signaling Pathway in Head and Neck Cancer -- 9. P53 in Head and Neck Squamous Cell Carcinoma -- 10. APOBEC as an Endogenous Mutagen in Cancers of the Head and Neck -- 11. The Genome-Wide Molecular Landscape of HPV-Driven and HPV-Negative Head and Neck Squamous Cell Carcinoma -- 12. Epigenetic Changes and Epigenetic Targets in Head and Neck Cancer -- 13. Inflammation and Head and Neck Squamous Cell Carcinoma -- 14. Immunotherapy in Head and Neck Squamous Cell Carcinoma (HNSCC -- 15. The Clinical Impact of Hypoxia in Head and Neck Squamous Cell Carcinoma -- 16. Angiogenesis and Anti-angiogenic Therapy in Head and Neck Cancer -- 17. FAK as a Target for Therapy in Head and Neck Cancer -- 18. Diversity of Wnt/ß-Catenin Signaling in Head and Neck Cancer: Cancer Stem Cells, Epithelial-to-Mesenchymal Transition, and Tumor Microenvironment -- 19. Hyaluronan-Mediated CD44 Signaling Activates Cancer Stem Cells in Head and Neck Cancer -- 20. Biology and Epidemiology of Human Papillomavirus-Related Head and Neck Cancer -- 21. Treatment Paradigms in HPV-Associated SCCHN.
Format
e-Book
Location
Online
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Molecular Diagnosis and Targeting for Thoracic and Gastrointestinal Malignancy

https://libcat.nshealth.ca/en/permalink/provcat43374
Yutaka Shimada, Katsuhiko Yanaga, editors. --Singapore: Springer , c2018.
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Location
Online
This volume focuses on the clinical applications of molecular diagnosis and targeted therapy from the viewpoint of oncologists specializing in specific organs. In addition, it discusses the role of molecular diagnosis and targeted therapy in the course of surgical treatment. Recent, rapid advances in molecular biology have shed new light on the mechanisms of cancer progression, and molecularly targeted drugs have been used to treat a variety of malignant diseases. For the diagnosis and precise …
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Other Authors
Shimada, Yutaka
Yanaga, Katsuhiko
Responsibility
Yutaka Shimada, Katsuhiko Yanaga, editors
Place of Publication
Singapore
Publisher
Springer
Date of Publication
c2018
Physical Description
1 online resource (viii, 156 p.) : 42 illus., 35 illus. in color
Series Title
Current human cell research and applications
ISBN
9789811064692
9789811064685 (print ed.)
9789811064708 (print ed.)
ISSN
2522-073X
Subjects (MeSH)
Gastrointestinal Neoplasms - diagnosis
Gastrointestinal Neoplasms - genetics
Molecular Diagnostic Techniques - methods
Molecular Targeted Therapy - methods
Thoracic Neoplasms - diagnosis
Thoracic Neoplasms - genetics
Specialty
Medical Oncology
Molecular Medicine
Abstract
This volume focuses on the clinical applications of molecular diagnosis and targeted therapy from the viewpoint of oncologists specializing in specific organs. In addition, it discusses the role of molecular diagnosis and targeted therapy in the course of surgical treatment. Recent, rapid advances in molecular biology have shed new light on the mechanisms of cancer progression, and molecularly targeted drugs have been used to treat a variety of malignant diseases. For the diagnosis and precise treatment of cancer, analysis of the molecular background of the tumor is indispensable. However, there are both tumor-specific and comprehensive mechanisms involved in these processes. Accordingly, a firm grasp of molecular diagnosis and targeted therapies for different tumors is vital for clinicians and basic researchers alike. This book provides essential information and the latest findings on molecular diagnosis and targeted therapy for thoracic and gastrointestinal malignancies. Though primarily intended for clinical and basic oncologists, it also offers a useful guide for clinicians who are interested in this field and are considering getting started in molecular diagnosis and targeted therapy.
Contents
1. Molecular biology of lung cancer in relation to precision medicine -- 2. Molecular diagnosis and targeting for breast cancer -- 3. Clinical application of stem cell biology in esophageal cancer -- 4. Molecular diagnosis and targeted therapy for gastric cancer -- 5. Molecular diagnosis and targeted therapy for colorectal cancer -- 6. Molecular and immunologic targets for the treatment of hepatocellular carcinoma -- 7. Molecular diagnosis and targeting for biliary tract cancer -- 8. Molecular analysis for therapeutic targets of pancreatic cancer -- 9. Molecular targeted therapy and diagnosis for gastroenteropancreatic neuroendocrine tumors.
Format
e-Book
Location
Online
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Molecular Diagnostics in Cancer Patients

https://libcat.nshealth.ca/en/permalink/provcat44270
Kamla Kant Shukla, Praveen Sharma, Sanjeev Misra, editors. --Singapore: Springer , 2019.
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Location
Online
This book aims to bring together a broad variety of examples of the role of pharmacogenomics in current drug development, uncovering dynamic concentration-dependent drug responses on biological systems to understand pharmacodynamics responses in human cancer where genetic lesions serve as tumor markers and provide a basis for cancer diagnosis. The book describes methods and protocols applied in molecular diagnostics. It offers pathologists and researchers providing molecular diagnostic services…
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Other Authors
Shukla, Kamla Kant
Sharma, Praveen
Misra, Sanjeev
Responsibility
Kamla Kant Shukla, Praveen Sharma, Sanjeev Misra, editors
Place of Publication
Singapore
Publisher
Springer
Date of Publication
2019
Physical Description
1 online resource (viii, 341 p.) : 45 illus., 43 illus. in color
ISBN
9789811358777
9789811358760 (Print ed.)
9789811358784 (Print ed.)
Subjects (MeSH)
Biomarkers, Tumor
Molecular Diagnostic Techniques
Neoplasms - diagnosis
Pharmacogenetics
Specialty
Medical Oncology
Molecular Medicine
Abstract
This book aims to bring together a broad variety of examples of the role of pharmacogenomics in current drug development, uncovering dynamic concentration-dependent drug responses on biological systems to understand pharmacodynamics responses in human cancer where genetic lesions serve as tumor markers and provide a basis for cancer diagnosis. The book describes methods and protocols applied in molecular diagnostics. It offers pathologists and researchers providing molecular diagnostic services an array of the most recent and readily accessible reference to compare methods and techniques. Highlights include the molecular diagnosis of genetic aberrations by quantitative polymerase reaction (qPCR), sequence-specific oligonucleotide arrays, next-generation sequencing (NGS), CGH arrays-and methodologies directed at the detection of epigenetic events, high-throughput nucleic acid and protein arrays, direct sequencing and FISH-based methodologies, currently used in the diagnosis of solid tumors. The book also includes an innovative line of treatment in relation to the molecular prognosis, diagnosis and pharmacogenomics in the actual practice of clinical findings at molecular levels. The book covers the applications of numerous genetic testing methodologies; in approximately the chronological order of discovery and high-throughput diagnosis using advanced genomic approaches to identify such genes, in the search for novel drug targets and/or key determinants of drug reactions. It also promotes a wider understanding of molecular diagnostics among physicians, medical students, and scientists in academics, industry and corporate world.
Contents
1. Recent Advances in Molecular Diagnostic Approaches for Cancer -- 2. Molecular Diagnosis of Gall Bladder Cancer -- 3. Molecular Diagnostics for Lung Cancer -- 4. Predicting E3 Ubiquitin Ligases as Possible Promising Biomarkers for Brain Tumors -- 5. Molecular Diagnostics in Melanoma: An Update -- 6. Molecular Diagnostics in Breast Cancer -- 7. Molecular Diagnostics in Non-Hodgkin Lymphoma -- 8. Molecular Diagnosis of Cervical Cancer -- 9. Molecular Diagnostics in Colorectal Cancer -- 10. Molecular Diagnostics in Pancreatic Cancer -- 11. Molecular Diagnostics in Head and Neck Squamous Cell Carcinoma -- 12. Molecular Diagnostic in Prostate Cancer -- 13. Molecular Diagnostics in Renal Cancer -- 14. Molecular Biomarkers and Urinary Bladder Cancer (UBC) -- 15. Molecular Pathway and Fluorescence In Situ Hybridization Testing of ERBB2 (HER2) Gene Amplification in Invasive Ductal Carcinoma of Breast -- 16. Exploring Potential of RPPA Technique in Oral Cancer Biomarker Discovery Research -- 17. Molecular Diagnostics in Liver Cancer -- 18. Molecular Diagnosis of Uterine Cancer -- 19. Molecular Diagnosis in Ovarian Carcinoma.
Format
e-Book
Location
Online
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Molecular medicine : genomics to personalized healthcare

https://libcat.nshealth.ca/en/permalink/provcat31947
Ronald J. Trent. (4th ed.) --Amsterdam ; Boston: Elsevier / Academic Press , c2012.
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Registration required for PDF access.
Location
Online
Molecular Medicine is the application of genetic or DNA-based knowledge to the modern practice of medicine. Molecular Medicine, 4e, provides contemporary insights into how the genetic revolution is influencing medical thinking and practice. The new edition includes recent changes in personalized medicine, new growth in omics and direct-to-consumer DNA testing, while focusing on advances in the Human Genome project and implications of the advances in clinical medicine. Graduate students, researc…
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Author
Trent, RJ
Responsibility
Ronald J. Trent
Edition
4th ed.
Alternate Title
Genomics to personalized healthcare
Place of Publication
Amsterdam ; Boston
Publisher
Elsevier / Academic Press
Date of Publication
c2012
Physical Description
1 online resource (336 p.)
ISBN
9780123814517 (electronic bk.)
Subjects (MeSH)
Genetics, medical - methods
Genomics - methods
Individualized Medicine
Subjects (LCSH)
Medical genetics
Molecular biology
Pathology, Molecular
Genomics
Molecular Medicine
Abstract
Molecular Medicine is the application of genetic or DNA-based knowledge to the modern practice of medicine. Molecular Medicine, 4e, provides contemporary insights into how the genetic revolution is influencing medical thinking and practice. The new edition includes recent changes in personalized medicine, new growth in omics and direct-to-consumer DNA testing, while focusing on advances in the Human Genome project and implications of the advances in clinical medicine. Graduate students, researchers, clinicians and allied health professionals will appreciate the background history and clinical application of up-to-date molecular advances. Extensively revised to incorporate the results of the Human Genome Project, it provides the latest developments in molecular medicineThe only book in Molecular Medicine to reach its fourth edition Identifies current practice as well as future developmentsPresents extensive tables, well presented figures and resources for further understanding.
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Format
e-Book
Location
Online
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Molecular pharmacology

https://libcat.nshealth.ca/en/permalink/provcat18958
American Society for Pharmacology and Experimental Therapeutics
Available Online
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Holdings
Vol 51, 1997 - (delayed 12 months)
Location
Online
Available Online
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Publisher
American Society for Pharmacology and Experimental Therapeutics
Holdings
Vol 51, 1997 - (delayed 12 months)
Publication Frequency
Monthly
ISSN
1521-0111
Specialty
Molecular Medicine
Pharmacology
Format
e-Journal
Location
Online
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Molecular Targeted Radiosensitizers : Opportunities and Challenges

https://libcat.nshealth.ca/en/permalink/provcat45329
Henning Willers, Iris Eke, editors. --Cham: Humana Press , c2020.
Available Online
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Location
Online
Molecular Targeted Radiosensitizers: Opportunities and Challenges provides the reader with a comprehensive review of key pre-clinical research components required to identify effective radiosensitizing drugs. The book features discussions on the mechanisms and markers of clinical radioresistance, pre-clinical screening of targeted radiosensitizers, 3D radiation biology for studying radiosensitizers, in vivo determinations of local tumor control, genetically engineered mouse models for studying …
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Other Authors
Willers, Henning
Eke, Iris
Responsibility
Henning Willers, Iris Eke, editors
Place of Publication
Cham
Publisher
Humana Press
Date of Publication
c2020
Physical Description
1 online resource (xi, 364 p.) : 42 illus., 38 illus. in color
Series Title
Cancer drug discovery and development
ISBN
9783030497019
9783030497002 (Print ed.)
9783030497026 (Print ed.)
9783030497033 (Print ed.)
ISSN
2196-9906
Subjects (MeSH)
Molecular Medicine
Neoplasms - radiotherapy
Radiation-Sensitizing Agents
Radiotherapy - methods
Specialty
Medical Oncology
Pharmacology
Radiotherapy
Abstract
Molecular Targeted Radiosensitizers: Opportunities and Challenges provides the reader with a comprehensive review of key pre-clinical research components required to identify effective radiosensitizing drugs. The book features discussions on the mechanisms and markers of clinical radioresistance, pre-clinical screening of targeted radiosensitizers, 3D radiation biology for studying radiosensitizers, in vivo determinations of local tumor control, genetically engineered mouse models for studying radiosensitizers, targeting the DNA damage response for radiosensitization, targeting tumor metabolism to overcome radioresistance, radiosensitizers in the era of immuno-oncology, and more. Additionally, the book features discussions on high-throughput drug screening, predictive biomarkers, pre-clinical tumor models, and the influence of the tumor microenvironment and the immune system, with a specific focus on the challenges radiation oncologists and medical oncologists currently face in testing radiosensitizers in human cancers. Edited by two acclaimed experts in radiation biology and radiosensitizers, with thirteen chapters contributed by experts, this new volume presents an in-depth look at current developments within a rapidly moving field, with a look at where the field will be heading and providing comprehensive insight into the framework of targeted radiosensitzer development. Essential reading for investigators in cancer research and radiation biology.
Contents
Introduction to Molecular Targeted Radiosensitizers: Opportunities and Challenges -- Translating Targeted Radiosensitizers into the Clinic -- Mapping the Radiogenome of Human Cancers -- Mechanisms and Markers of Clinical Radioresistance -- Preclinical Strategies for Testing of Targeted Radiosensitizers -- 3D Radiation Biology for Identifying Radiosensitizers -- Preclinical In Vivo Evaluation of Novel Radiosensitizers by Local Tumor Control Experiments -- Genetically Engineered Mouse Models for Studying Radiation Biology and Radiosensitizers -- Targeting the DNA Damage Response for Radiosensitization -- Targeting Tumor Metabolism to Overcome Radioresistance -- Targeting Tumor Hypoxia -- Normalizing the Tumor Microenvironment for Radiosensitization -- Radiosensitizers in the Era of Immuno-Oncology.
Format
e-Book
Location
Online
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