This book describes the role of basic and advanced imaging techniques in the diagnosis of different types of cardiomyopathy, including dilated cardiomyopathy, hypertrophic cardiomyopathy, restrictive cardiomyopathy, arrhythmogenic right ventricular cardiomyopathy and infiltrative/storage cardiomyopathies. While the main focus is on echocardiography, the applications of cardiac magnetic resonance imaging and computed tomography are also described. Throughout, a clinically oriented approach is em…
In dilated cardiomyopathy (DCM), the heart muscle becomes weak. This makes it harder for the heart to pump blood out to the body. This causes the bottom chambers to dilate (stretch). A weak heart can also cause fluid to build up in parts of the body like the lungs (causing shortness of breath) and the ankles or belly (causing swelling). DCM may also affect the electrical activity of the heart and can cause fast, dangerous heart rhythms. The pamphlet gives the causes of DCM, symptoms, diagnostic…
This extensively revised second edition traces the development of the basic concepts in cardiovascular physiology in light of the accumulated experimental and clinical evidence. It considers the early embryonic circulation, where blood circulation suggests the existence of a motive force, tightly coupled to the metabolic demands of the tissues. It proposes that rather than being an organ of propulsion, the heart, serves as an organ of control, generating pressure by rhythmically impeding blood …
What drives the circulation? In this comprehensive review of existing circulation models, the conventional view that the heart is a pressure-propulsion pump is challenged. The existing models fail to explain an increasing number of observed circulatory phenomena. A unifying circulation model is proposed in which the blood, responding to metabolic demands of the tissues, is the primary regulator of cardiac output. This new model arises from accumulated clinical and experimental evidence. The hea…
In HCM, there is a thickening of the heart muscle, usually in the wall between the 2 lower chambers (the septum). When the muscle thickens, it gets stiff and makes it hard for the bottom chambers to relax and fill with blood before each heartbeat. Thickening can also make it harder for blood to leave the heart. This can lower the amount of blood the heart can pump out to the rest of the body. Thickening of the heart muscle can create scar tissue. This can make you more at risk of dangerous, fas…
Over the past two decades, due to dramatic advances in molecular and cell biology, biochemistry, and genetics, our view on mitochondria as a relatively static cellular powerhouse has changed radically. We now know that these organelles play a critical role in the normal and in the damaged heart. Written by Dr. JosĂ© MarĂn-GarcĂa, Director of the Molecular Cardiology and Neuromuscular Institute, Mitochondria and Their Role in Cardiovascular Disease brings readers up- to-date on the many significa…
This timely book reveals an integrated approach to myocardial preservation focusing on translational research and clinical applications. Chapters cover both the mechanisms of heart failure in addition to therapeutic considerations, including forms of cardiac cell death, cardiac remodelling and cardiac regeneration. Potential future research directions are also proposed, enabling the reader to gain a broad in-depth understanding of the topic. Myocardial Preservation: Translational Research and C…
This book reviews current knowledge and recent advances in the diagnosis and management of myopericardial diseases, a spectrum of medical diseases and syndromes affecting a significant proportion of patients in clinical practice and presenting either as an isolated process or as a manifestation of a systemic disease. Unlike in other books, both pericardial and myocardial diseases are fully covered. Detailed guidance is provided on diagnosis and the role of integrated cardiovascular imaging, med…
Translational Cardiology: Molecular Basis of Cardiac Metabolism, Cardiac Remodeling, Translational Therapies and Imaging Techniques provides an up-to-date introduction to the role circadian rhythms, cardiac plasticity, and mechanotransduction play in the heart, while at the same time introducing new developments in cellular, viral, and non-biologic therapies that are in the process of being developed. Importantly, the focus of this book is on topics that, due to their novelty, are largely not c…