topic:"Neoplasm Staging - methods" found 4 records - Provincial Hospitals Library Catalogue

Applied Immunohistochemistry in the Evaluation of Skin Neoplasms

https://libcat.nshealth.ca/en/permalink/provcat40172

Jose A. Plaza, Victor G. Prieto, editors. --Cham: Springer , c2016.

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Location: Online

This book provides a comprehensive, state-of-the-art account of the role of immunohistochemistry in the diagnosis of skin tumors, which is crucial given that overlapping histologic features and unusual morphologic changes can lead to considerable diagnostic uncertainty. The book reviews in detail the sensitivity and specificity of commonly available antibodies and their pattern of immunostaining. Readers will learn when to order antibodies and how to interpret findings. In addition, prognostic …

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Other Authors: Plaza, Jose A; Prieto, Victor G

Responsibility: Jose A. Plaza, Victor G. Prieto, editors

Place of Publication: Cham

Publisher: Springer

Date of Publication: c2016

Physical Description: 1 online resource (ix, 385 p. : 264 illus., 159 illus. in color)

ISBN: 9783319305905; 9783319305882 (print ed.)

Subjects (MeSH): Immunohistochemistry - methods; Neoplasm Staging - methods; Skin Neoplasms - diagnosis

Abstract: This book provides a comprehensive, state-of-the-art account of the role of immunohistochemistry in the diagnosis of skin tumors, which is crucial given that overlapping histologic features and unusual morphologic changes can lead to considerable diagnostic uncertainty. The book reviews in detail the sensitivity and specificity of commonly available antibodies and their pattern of immunostaining. Readers will learn when to order antibodies and how to interpret findings. In addition, prognostic markers are evaluated and emphasis placed on the pitfalls commonly encountered when evaluating these neoplasms. The informative text is complemented by a wealth of superb images. Helpful histograms and algorithms are included, and clear guidance is provided on the application and interpretation of less commonly used antibodies and immunostains. With the emergence of many immunomarkers, immunohistochemistry has become a vital ancillary diagnostic tool in dermatopathology and an essential adjunct for the correct identification of skin neoplasms. Indeed, immunohistochemistry has replaced simple morphologic evaluation as the definitive diagnostic method for various tumor types. The complexity of some skin neoplasms makes it imperative that the role of immunohistochemistry in subtyping these conditions is clearly understood. Against this background, Applied Immunohistochemistry in the Evaluation of Skin Neoplasms will serve as an extremely valuable resource for practicing dermatopathologists and pathologists.

Contents: Part I. Immunohistology of Epithelial Tumors -- Immunohistology and Molecular Studies of Epithelial Tumors -- Part II. Adnexal Neoplasms -- Immunohistology and Molecular Studies of Sweat Gland Tumors -- Immunohistology and Molecular Studies of Follicular Tumors -- Use of Immunohistochemical and Molecular Studies in the Evaluation of the Sebaceous Neoplasms -- Part III. Immunohistology of Cutaneous Metastases and Its Simulators -- Cutaneous Metastasis -- Part IV. Immunohistology of Mesenchymal Neoplasms -- Immunohistology and Molecular Studies of Fibrohistiocytic and Myofibroblastic Cutaneous Tumors -- Immunohistology and Molecular Studies of Smooth Muscle and Neural Cutaneous Tumors -- New Insights in Vascular Lesions Development and Identification with Immunohistochemical Markers -- Part V. Immunohistology of Cutaneous Lymphoma -- Immunohistology and Molecular Studies of Cutaneous B-cell Lymphomas -- Immunohistology and Molecular Studies of Cutaneous T-cell Lymphomas and Mimics -- Immunohistology of Leukemia Cutis and Histiocytic Tumors -- Part VI. Immunohistology of Melanocytic Lesions -- Immunohistology of Melanocytic Lesions -- Part VII. Molecular Studies of Melanocytic Lesions -- Molecular Studies of Melanocytic Lesions -- Part VIII. Immunohistology of Sentinel Lymph Node in Melanoma -- Sentinel Lymph Node in Melanoma.

Format: e-Book

Location: Online

Imaging tumor response to therapy

https://libcat.nshealth.ca/en/permalink/provcat31258

Massimo Aglietta, Daniele Regge, editors. --Milan: Springer , c2012.

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Location: Online

Measurement of solid tumor response to treatment relies mainly on imaging. WHO tumor response criteria and, more recently, RECIST (response evaluation criteria in solid tumors) have provided means to objectively measure tumor response in clinical trials with imaging. These guidelines have been rapidly adopted in clinical practice to monitor patient treatment and for therapy planning. However, relying only on anatomical information is not always sufficient when evaluating new drugs that will red…

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Other Authors: Aglietta, Massimo; Regge, Daniele

Responsibility: Massimo Aglietta, Daniele Regge, editors

Alternate Title: Imaging tumour response to therapy

Place of Publication: Milan

Publisher: Springer

Date of Publication: c2012

Physical Description: 1 online resource (xvii, 157 p.)

ISBN: 9788847026131

Subjects (MeSH): Antineoplastic Agents - therapeutic use; Diagnostic Imaging; Neoplasm Staging - methods; Neoplasms - drug therapy; Treatment Outcome

Subjects (LCSH): Radiology, Medical; Nuclear medicine; Oncology

Abstract: Measurement of solid tumor response to treatment relies mainly on imaging. WHO tumor response criteria and, more recently, RECIST (response evaluation criteria in solid tumors) have provided means to objectively measure tumor response in clinical trials with imaging. These guidelines have been rapidly adopted in clinical practice to monitor patient treatment and for therapy planning. However, relying only on anatomical information is not always sufficient when evaluating new drugs that will reduce a tumor's functionality while preserving its size. Finding more reliable and reproducible measures of tumor response is one of the most important and difficult challenges facing modern radiology as it requires an entirely new approach to imaging. The aim of this book is to address the assessment of response to treatment by adopting a multidisciplinary perspective, just as occurs in real life in a comprehensive cancer center. Oncologists and imaging experts consider two cancer models, locally advanced disease and metastatic disease, jointly exploring both conventional and advanced means of measuring response to standard treatment protocols and new targeted therapies.

Contents: Part I. Methodological Bases -- 1. Surrogate Endpoints of Clinical Benefit -- 2. Response to Treatment: the Role of Imaging -- Part II. RECIST and Beyond: Assessing the Response to Treatment in Metastatic Disease -- 3. Gastrointestinal Stromal Tumors -- 4. Renal Cancer -- 5. Liver Metastases in Colon Cancer -- Part III. RECIST and Beyond: Assessing the Response to Treatment in Locally Advanced Disease -- 6. Neoadjuvant Therapy in Breast Cancer -- 7. Lung Cancer -- 8. Pancreatic Cancer -- 9. Hepatocellular Carcinoma.