Adipocytokines, Energy Balance, and Cancer
https://libcat.nshealth.ca/en/permalink/provcat41392
Ofer Reizes, Nathan A. Berger, editors.
--Cham:
Springer
, 2017.
- Available Online
- View e-Book
- Location
- Online
Adipocytokines provide the circuitry by which adipose tissue communicates among its component cells which include adipocytes, stromal cells, immune cells and vascular elements, with adipose tissue depots in other locations throughout the body and with other tissues in order to regulate physiologic processes of energy intake, utilization, and distribution. Since disturbances, both qualitative and quantitative, in adipocytokine function contribute significantly to many of the comorbidities associ…
- Available Online
- View e-Book
- Other Authors
- Reizes, Ofer
- Berger, Nathan A
- Responsibility
- Ofer Reizes, Nathan A. Berger, editors
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- 2017
- Physical Description
- 1 online resource (xii, 302 pages) : 19 illus., 16 illus. in color
- Series Vol.
- 12
- Series Title
- Energy balance and cancer
- ISBN
- 9783319416779
- 9783319416755 (print ed.)
- ISSN
- 2199-2622
- Subjects (MeSH)
- Adipokines
- Energy metabolism - physiology
- Neoplasms - etiology
- Neoplasms - metabolism
- Obesity - complications
- Abstract
- Adipocytokines provide the circuitry by which adipose tissue communicates among its component cells which include adipocytes, stromal cells, immune cells and vascular elements, with adipose tissue depots in other locations throughout the body and with other tissues in order to regulate physiologic processes of energy intake, utilization, and distribution. Since disturbances, both qualitative and quantitative, in adipocytokine function contribute significantly to many of the comorbidities associated with obesity, including diabetes, cardiovascular disease and cancer, this volume, which discusses most of the major adipocytokines independently and collectively and their roles in normal and pathologic processes, should be useful to all individuals seeking a deeper understanding of these processes. Moreover, it provides a valuable complement to the series on Energy Balance and Cancer, in which each volume is focused on a specific aspect of this process, which now constitutes an expanding problem as the obesity pandemic continues and more of the population reaches the age where cancer is most prevalent. This volume should provide a valuable resource to all clinicians and scientists engaged in caring for susceptible patients and in exploring the relation between energy balance and cancer as well as an important platform to providing the background for research development.
- Contents
- Preface -- 1. Adipocytes, Adipocytokines, and Cancer -- 2. Adiponectin, Obesity, and Cancer -- 3. Leptin in Cancer; Epidemiology and Mechanisms -- 4. Leptin Signaling Pathways as Therapeutic Targets in Cancer -- 5. Retinol Binding Protein 4: Role in Diabetes and Cancer -- 6. Visfatin, Obesity, and Cancer -- 7. Apelin and Cancer -- 8. Novel Adipocytokines: Monocyte Chemotactic Protein-1, Plasminogen Activator Inhibitor-1, Chemerin -- 9. Resistin, Obesity, and Cancer -- 10. CRP Role in Cancer -- 11. GI Peptides, Energy Balance and Cancer -- Index.
- Format
- e-Book
- Location
- Online
Caveolins in Cancer Pathogenesis, Prevention and Therapy
https://libcat.nshealth.ca/en/permalink/provcat30929
Isabelle Mercier, Jean-François Jasmin, Michael P. Lisanti, editors.
--New York, NY:
Springer
, c2012.
- Available Online
- View e-Book
- Location
- Online
For more than a decade, caveolin proteins have attracted a lot of attention in the field of cancer research. Additional roles besides maintaining the structural integrity of caveolae (meaning "little caves" in latin) have been attributed to these complex proteins. In fact, they have emerged as important regulators of cell signaling, proliferation, invasion and angiogenesis. The current book focuses on caveolin-1, the best-studied and well- characterized of all three caveolin family members (cav…
- Available Online
- View e-Book
- Other Authors
- Mercier, Isabelle
- Jasmin, Jean-François
- Lisanti, Michael P
- Responsibility
- Isabelle Mercier, Jean-François Jasmin, Michael P. Lisanti, editors
- Place of Publication
- New York, NY
- Publisher
- Springer
- Date of Publication
- c2012
- Physical Description
- 1 online resource (xi, 123 p. : 12 ill., 11 ill. in color)
- Series Title
- Current cancer research
- ISBN
- 9781461410010
- Subjects (MeSH)
- Caveolae - pathology
- Caveolin 1 - metabolism
- Caveolin 1 - physiology
- Neoplasms - metabolism
- Signal transduction
- Tumor Markers, Biological - metabolism
- Subjects (LCSH)
- Oncology
- Biochemistry
- Abstract
- For more than a decade, caveolin proteins have attracted a lot of attention in the field of cancer research. Additional roles besides maintaining the structural integrity of caveolae (meaning "little caves" in latin) have been attributed to these complex proteins. In fact, they have emerged as important regulators of cell signaling, proliferation, invasion and angiogenesis. The current book focuses on caveolin-1, the best-studied and well- characterized of all three caveolin family members (caveolin-1, -2 and -3). As such, the current chapters illustrate the roles of caveolin-1 in breast, prostate, skin, colon, brain and pancreatic cancers, and highlight its specific contribution to tumor growth through epithelial and stromal interactions, as well as its involvement in angiogenesis. This book summarizes the existing literature and provides interesting new perspectives on future advancement and therapeutic possibilities involving caveolins in cancer. This work brings together highly respected and experienced scientists in the field of caveolins who wrote informative chapters on the role of caveolin-1 in cancer in a format that conveys its role as both a tumor suppressor and tumor promoter. We invite you to read, enjoy and be part of these new promising discoveries that are rapidly advancing the field of cancer research.
- Contents
- Preface -- Local and Distant Effects of Caveolin-1 on Prostate Cancer Progression -- Caveolin-1 in Colon Cancer: the Flexible Connection to Wnt Signaling -- Caveolin-1 and Pancreatic Ductal Adenocarcinoma -- Caveolin-1 in Brain Tumors -- The Role of Caveolin-1 in Skin Cancer -- Caveolins and Tumor Angiogenesis -- Caveolin-1 and Breast Cancer -- Caveolin-1 and Cancer-Associated Stromal Fibroblasts -- Index.
- Format
- e-Book
- Location
- Online
Cell Cycle Deregulation in Cancer
https://libcat.nshealth.ca/en/permalink/provcat29848
edited by Greg H. Enders.
--New York, NY:
Springer Science+Business Media
, c2010.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Author
- Enders, Greg H
- Responsibility
- edited by Greg H. Enders
- Place of Publication
- New York, NY
- Publisher
- Springer Science+Business Media
- Date of Publication
- c2010
- Series Title
- Current cancer research
- ISBN
- 9781441917706
- Subjects (MeSH)
- Cell Cycle - physiology
- Cell Proliferation
- Neoplasms - metabolism
- Format
- e-Book
- Location
- Online
Color Atlas of Immunocytochemistry in Diagnostic Cytology
https://libcat.nshealth.ca/en/permalink/provcat30417
edited by Parvin Ganjei-Azar, Mehrdad Nadji.
--Boston, MA:
Springer Science+Business Media
, c2007.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Author
- Ganjei-Azar, Parvin
- Other Authors
- Nadji, Mehrdad
- Responsibility
- edited by Parvin Ganjei-Azar, Mehrdad Nadji
- Place of Publication
- Boston, MA
- Publisher
- Springer Science+Business Media
- Date of Publication
- c2007
- ISBN
- 9780387321226
- Subjects (MeSH)
- Cytodiagnosis - Atlases
- Immunohistochemistry - methods - Atlases
- Neoplasms - diagnosis - Atlases
- Neoplasms - metabolism
- Tumor Markers, Biological
- Subjects (LCSH)
- Cytology
- Immunology
- Pathology
- Format
- e-Book
- Location
- Online
EGFR Signaling Networks in Cancer Therapy
https://libcat.nshealth.ca/en/permalink/provcat29612
edited by William John Gullick, John D. Haley.
--Totowa, NJ:
Humana Press
, c2008.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Author
- Gullick, William John
- Other Authors
- Haley, John D
- Responsibility
- edited by William John Gullick, John D. Haley
- Place of Publication
- Totowa, NJ
- Publisher
- Humana Press
- Date of Publication
- c2008
- Series Title
- Cancer drug discovery and development
- ISBN
- 9781597453561
- Subjects (MeSH)
- Neoplasms - drug therapy
- Neoplasms - metabolism
- Receptor, Epidermal Growth Factor - antagonists & inhibitors
- Receptor, Epidermal Growth Factor - metabolism
- Signal transduction - drug effects
- Subjects (LCSH)
- Oncology
- Biochemistry
- Format
- e-Book
- Location
- Online
Energy Balance and Hematologic Malignancies
https://libcat.nshealth.ca/en/permalink/provcat30967
Steven D. Mittelman, Nathan A. Berger, editors.
--New York, NY:
Springer
, c2012.
- Available Online
- View e-Book
- Location
- Online
The obesity pandemic continues to increase on a world-wide basis with over 70% of the United States population being either overweight or obese. Hematologic malignancies have recently been identified among the obesity associated malignancies spanning the lifespan from childhood to the elderly and include leukemia, myeloma, lymphoma and others. In addition to the potential etiologic association between obesity and hematologic malignancies, the presence of obesity has profound effects on therapy …
- Available Online
- View e-Book
- Other Authors
- Mittelman, Steven D
- Berger, Nathan A
- Responsibility
- Steven D. Mittelman, Nathan A. Berger, editors
- Place of Publication
- New York, NY
- Publisher
- Springer
- Date of Publication
- c2012
- Physical Description
- 1 online resource (x, 184 p. : 19 ill., 18 ill. in color)
- Series Vol.
- v. 5
- Series Title
- Energy balance and cancer
- ISBN
- 9781461424031
- Subjects (MeSH)
- Energy metabolism - physiology
- Hematologic Neoplasms - etiology
- Hematologic Neoplasms - metabolism
- Obesity - complications
- Obesity - metabolism
- Subjects (LCSH)
- Hematology
- Oncology
- Abstract
- The obesity pandemic continues to increase on a world-wide basis with over 70% of the United States population being either overweight or obese. Hematologic malignancies have recently been identified among the obesity associated malignancies spanning the lifespan from childhood to the elderly and include leukemia, myeloma, lymphoma and others. In addition to the potential etiologic association between obesity and hematologic malignancies, the presence of obesity has profound effects on therapy by impacting pharmacokinetics of chemotherapeutic agents, dose, adipocyte metabolism and drug distribution. These may be particularly important in hematopoietic stem cell transplantation. Another important aspect of the association of obesity with hematologic malignancies is the increased incidence of obesity in children who successfully complete therapy for acute lymphoblastic leukemia. This and other observations indicate important relations between the hematopoietic systems and adipose tissue metabolism. Energy Balance in Hematologic Malignancies will provide an important volume in the series on Energy Balance and Cancer and serve as a basis for better understanding etiology, mechanisms, therapeutic implications and experimental approaches. While this book should be of specific interest and utility to all pediatric and adult hematologists and oncologists dealing with hematologic malignancies, it should also provide an important resource for all investigators concerned, from a clinical or research basis, with the impact of obesity and exercise on hematologic malignancies.
- Contents
- Preface -- The Epidemiology of Obesity and Hematologic Malignancies -- Adipocytes, Lipid Metabolism and Hematopoiesis -- Mechanisms Linking Obesity and Leukemia Prognosis -- Obesity and Multiple Myeloma -- The Impact of Obesity on Pharmacokinetics and Dosing of Leukemia Chemotherapy -- The Impact of Obesity on Stem Cell Transplant -- Obesity Following Childhood Leukemia: Mechanisms and Consequences -- Physical Activity and Recovery from Hematological Malignancy -- Index.
- Format
- e-Book
- Location
- Online
Energy Balance and Prostate Cancer
https://libcat.nshealth.ca/en/permalink/provcat43025
Elizabeth A. Platz, Nathan A. Berger, editors.
--Cham:
Springer
, c2018.
- Available Online
- View e-Book
- Location
- Online
This volume provides a comprehensive treatise on the latest studies linking prostate cancer with energy balance, which together constitute a major challenge and opportunity for research scientists and clinicians especially those dealing with the expanding population of older men confronted with obesity and associated comorbidities. This volume should be a valuable resource to physicians, oncologists, urologists, endocrinologists, nurses, nutritionists, dieticians, and exercise therapists dealin…
- Available Online
- View e-Book
- Other Authors
- Platz, Elizabeth A.
- Berger, Nathan A.
- Responsibility
- Elizabeth A. Platz, Nathan A. Berger, editors
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2018
- Physical Description
- 1 online resource (xii, 187 p.) : 11 illus., 10 illus. in color
- Series Vol.
- v. 14
- Series Title
- Energy balance and cancer
- ISBN
- 9783319649405
- 9783319649399 (print ed.)
- 9783319649412 (print ed.)
- 9783319879062 (print ed.)
- ISSN
- 2199-2622
- Subjects (MeSH)
- Energy Metabolism
- Obesity - complications
- Prostatic Neoplasms - etiology
- Prostatic Neoplasms - metabolism
- Risk Factors
- Specialty
- Medical Oncology
- Physiology
- Urology
- Abstract
- This volume provides a comprehensive treatise on the latest studies linking prostate cancer with energy balance, which together constitute a major challenge and opportunity for research scientists and clinicians especially those dealing with the expanding population of older men confronted with obesity and associated comorbidities. This volume should be a valuable resource to physicians, oncologists, urologists, endocrinologists, nurses, nutritionists, dieticians, and exercise therapists dealing with men with energy balance issues and/or questions regarding the linkage between energy balance and cancer. Moreover, this volume should serve as an important resource for cancer researchers especially for scientists studying lifestyle modification and prevention strategies to better understand and disrupt the linkage between obesity and cancer.
- Contents
- 1. Epidemiology, Energy Balance and Prostate Cancer Incidence and Mortality -- 2. Racial/Ethnic Differences in the Association between Energy Balance and Prostate Cancer -- 3. Consequence of Energy Imbalance in Prostate Cancer and Comorbidities -- 4. Adipokines and Prostate Cancer -- 5. Cross-Sectional Epidemiology and Intervention Studies of Mediators of the Energy Imbalance-Prostate Cancer Association -- 6. Impact of Metabolic Factors on Screening, Early Detection, and Management of Prostate Cancer -- 7. Androgen Deprivation Therapy for Prostate Cancer: Effects on Body Composition and Metabolic Health -- 8. The Integration of Exercise and Dietary Lifestyle Interventions into Prostate Cancer Care -- 9. Energy Balance-Based Strategies to Reduce Consequences of Prostate Cancer: How to Communicate with Men.
- Format
- e-Book
- Location
- Online
The Heterogeneity of Cancer Metabolism
https://libcat.nshealth.ca/en/permalink/provcat46283
Anne Le, editor.
(Second edition)
--Cham:
Springer
, c2021.
- Available Online
- View e-Book
- Access
- Open access
- Location
- Online
- Available Online
- View e-Book
- Other Authors
- Le, Anne
- Responsibility
- Anne Le, editor
- Edition
- Second edition
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2021
- Physical Description
- 1 online resource (xxiii, 271 pages)
- Series Vol.
- 1311
- Series Title
- Advances in experimental medicine and biology
- ISBN
- 9783030657680
- Subjects (MeSH)
- Neoplasms - metabolism
- Neoplastic Processes
- Specialty
- Pathology
- Physiology
- Medical Oncology
- Access
- Open access
- Format
- e-Book
- Location
- Online
Impact of energy balance on cancer disparities
https://libcat.nshealth.ca/en/permalink/provcat33884
Deborah J. Bowen, Gerald V. Denis, Nathan A. Berger, editors.
--Cham, Switzerland:
Springer
, c2014.
- Available Online
- View e-Book
- Location
- Online
This volume reviews disparities in cancer genetics, etiology, treatment and survivorship that are associated with differences in energy balance and how those differences and disparities may be affected by geography, socioeconomic status, ethnicity, biology, behavior and others. State-of-the-art strategies are outlined to alter these problems at the individual, community and policy levels. The book provides a comprehensive assessment of the multiple contributions of disparities in energy balance…
- Available Online
- View e-Book
- Other Authors
- Bowner, Deborah J.
- Denis, Gerald V.
- Berger, Nathan A.
- Responsibility
- Deborah J. Bowen, Gerald V. Denis, Nathan A. Berger, editors
- Place of Publication
- Cham, Switzerland
- Publisher
- Springer
- Date of Publication
- c2014
- Physical Description
- 1 online resource (xiii, 308 pages)
- Series Vol.
- v. 9
- Series Title
- Energy balance and cancer
- ISBN
- 9783319061030 (electronic bk.)
- 9783319061023
- Subjects (MeSH)
- Energy metabolism - physiology
- Health Status Disparities
- Neoplasms - ethnology
- Neoplasms - metabolism
- Obesity - complications
- Subjects (LCSH)
- Cancer - Research
- Abstract
- This volume reviews disparities in cancer genetics, etiology, treatment and survivorship that are associated with differences in energy balance and how those differences and disparities may be affected by geography, socioeconomic status, ethnicity, biology, behavior and others. State-of-the-art strategies are outlined to alter these problems at the individual, community and policy levels. The book provides a comprehensive assessment of the multiple contributions of disparities in energy balance and how they affect cancer. this volume should constitute a valuable resource to disparity focused investigators at all levels and serve s an important guide to professionals that deal with these issues, especially those who determine and implement policy.
- Contents
- Obesity and Cancer in Appalachia -- Disparities in Cancer Outcomes: A UK Perspective -- Behavioral Differences Leading to Disparities in Energy Balance and Cancer -- Impact of Obesity, Race, and Ethnicity on Cancer Survivorship -- The Biology of Aging: Role in Cancer, Metabolic Dysfunction, and Health Disparities -- Energy Balance and Multiple Myeloma in African Americans -- Single Nucleotide Polymorphisms in Obesity and Inflammatory Genes in African Americans with Colorectal Cancer -- Ethnic Differences in Insulin Resistance as a mediator of Cancer Disparities -- Role of Ethnic Differences in Mediators of Energy Balance -- Community-Based Strategies to Alter Energy Balance in Underserved Breast Cancer Survivors -- The Role of Policy in Reducing Inflammation -- Cancer Prevention through Policy Interventions that Alter Childhood Disparities in Energy.
- Format
- e-Book
- Location
- Online
Metabolism in Cancer
https://libcat.nshealth.ca/en/permalink/provcat40307
Thorsten Cramer, Clemens A. Schmitt, editors.
--Cham:
Springer
, c2016.
- Available Online
- View e-Book
- Location
- Online
This textbook presents concise chapters written by internationally respected experts on various important aspects of cancer-associated metabolism, offering a comprehensive overview of the central features of this exciting research field. The discovery that tumor cells display characteristic alterations of metabolic pathways has significantly changed our understanding of cancer: while the first description of tumor-specific changes in cellular energetics was published more than 90 years ago, the…
- Available Online
- View e-Book
- Other Authors
- Cramer, Thorsten
- A. Schmitt, Clemens
- Responsibility
- Thorsten Cramer, Clemens A. Schmitt, editors
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2016
- Physical Description
- 1 online resource (ix, 266 p. : 31 illus., 25 illus. in color)
- Series Vol.
- 207
- Series Title
- Recent results in cancer research
- ISBN
- 9783319421186
- 9783319421162 (print ed.)
- ISSN
- 0080-0015
- Subjects (MeSH)
- Neoplasms - genetics
- Neoplasms - metabolism
- Neoplastic Processes
- Abstract
- This textbook presents concise chapters written by internationally respected experts on various important aspects of cancer-associated metabolism, offering a comprehensive overview of the central features of this exciting research field. The discovery that tumor cells display characteristic alterations of metabolic pathways has significantly changed our understanding of cancer: while the first description of tumor-specific changes in cellular energetics was published more than 90 years ago, the causal significance of this observation for the pathogenesis of cancer was only discovered in the post-genome era. The first 10 years of the twenty-first century were characterized by rapid advances in our grasp of the functional role of cancer-specific metabolism as well as the underlying molecular pathways. Various unanticipated interrelations between metabolic alterations and cancer-driving pathways were identified and currently await translation into diagnostic and therapeutic applications. Yet the speed, quantity, and complexity of these new discoveries make it difficult for researchers to keep up to date with the latest developments, an issue this book helps to remedy.
- Contents
- The Role of Glucose and Lipid Metabolism in Growth and Survival of Cancer Cells -- Lactate—An Integrative Mirror of Cancer Metabolism -- Metabolic Reprogramming by the PI3K-Akt-mTOR Pathway in Cancer -- MYC, Metabolic Synthetic Lethality, and Cancer -- The Role of pH Regulation in Cancer Progression -- Metabolic Features of Cancer Treatment Resistance -- Tissue-Based Metabolomics to Analyze the Breast Cancer Metabolome -- Imaging of Tumor Metabolism Using Positron Emission Tomography (PET) -- Quantitative Analysis of Cancer Metabolism: From pSIRM to MFA -- Mathematical Modeling of Cellular Metabolism -- Ketogenic Diet and Cancer—a Perspective -- Fasting and Caloric Restriction in Cancer Prevention and Treatment.
- Format
- e-Book
- Location
- Online
Oncogenes Meet Metabolism : From Deregulated Genes to a Broader Understanding of Tumour Physiology
https://libcat.nshealth.ca/en/permalink/provcat28975
edited by G. Kroemer, D. Mumberg, H. Keun, B. Riefke, T. Steger-Hartmann, K. Petersen.
--Berlin, Heidelberg:
Springer-Verlag
, c2008.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Author
- Kroemer, G
- Other Authors
- Mumberg, D
- Keun, H
- Riefke, B
- Steger-Hartmann, T
- Petersen, K
- Responsibility
- edited by G. Kroemer, D. Mumberg, H. Keun, B. Riefke, T. Steger-Hartmann, K. Petersen
- Alternate Title
- Oncogenes meet metabolism : from deregulated genes to a broader understanding of tumor physiology
- Place of Publication
- Berlin, Heidelberg
- Publisher
- Springer-Verlag
- Date of Publication
- c2008
- Series Vol.
- 2007/4
- Series Title
- Ernst Schering Foundation Symposium Proceedings
- ISBN
- 9783540794783
- Subjects (MeSH)
- Neoplasms - genetics
- Neoplasms - metabolism
- Oncogenes
- Format
- e-Book
- Location
- Online
Sensitization of Cancer Cells for Chemo/Immuno/Radio-therapy
https://libcat.nshealth.ca/en/permalink/provcat40637
edited by Benjamin Bonavida.
--Totowa, NJ:
Humana Press
, c2008.
- Available Online
- View e-Book
- Location
- Online
Cancer chemotherapy can be traced back to the 1940's and since then the world has witnessed the discovery and the important application of several new drugs. The successes of combination chemotherapy suggested that all cancers can be treated provided that the correct combination of drugs at the correct doses and correct intervals are established. However, with time, tumor cells develop mechanisms of resistance to apoptosis and no longer respond to the majority of cytotoxic therapies. Sensitizat…
- Available Online
- View e-Book
- Other Authors
- Bonavida, Benjamin
- Responsibility
- edited by Benjamin Bonavida
- Place of Publication
- Totowa, NJ
- Publisher
- Humana Press
- Date of Publication
- c2008
- Physical Description
- 1 online resource (xxi, 419 p. : ill.)
- Series Title
- Cancer drug discovery and development
- ISBN
- 9781597454742
- 9781934115299 (print ed.)
- Subjects (MeSH)
- Antineoplastic Agents - therapeutic use
- Drug Resistance, Neoplasm
- Neoplasms - drug therapy
- Neoplasms - metabolism
- Radiation-Sensitizing Agents
- Radiotherapy - methods
- Abstract
- Cancer chemotherapy can be traced back to the 1940's and since then the world has witnessed the discovery and the important application of several new drugs. The successes of combination chemotherapy suggested that all cancers can be treated provided that the correct combination of drugs at the correct doses and correct intervals are established. However, with time, tumor cells develop mechanisms of resistance to apoptosis and no longer respond to the majority of cytotoxic therapies. Sensitization of Cancer Cells for Chemo/Immuno/Radio-therapy, edited by Benjamin Bonavida, reviews novel approaches developed to reverse tumor cell resistance to chemo/immuno/radio-therapy and the use of various sensitizing agents in combination with various cytotoxics. Such sensitizing agents target gene products that regulate resistance and therefore identify novel targets for drug development. This book also introduces several of the current approaches that have been developed by established investigators in the field that are aimed at overcoming resistance. This book is the first that compiles studies on tumor cell sensitization and is useful for students, scientists, clinicians and pharmaceutical companies.
- Contents
- Part I. Sensitization via Membrane-Bound Receptors -- Sensitization of Epithelial Cancer Cells with Human Monoclonal Antibodies -- Targeting the Transferrin Receptor to Overcome Resistance to Anti-Cancer Agents -- Chemo-Immunosensitization of Resistant B-NHL as a Result of Rituximab (anti-CD20 mAb)-Mediated Inhibition of Cell Survival Signaling Pathways -- Agents that Regulate DR5 and Sensitivity to TRAIL -- Proteasome Inhibition: Potential for Sensitization of Immune Effector Mechanisms in Cancer -- Part II. Sensitization via Inhibition of Cell Survival Pathways (Excluding Apoptotic Signaling Pathways) -- Angiogenesis Inhibitors as Enabling Agents for the Chemotherapeutic Treatment of Metastatic Disease -- Targeting Survival Cascades Induced by Activation of Ras/Raf/MEK/ERK and PI3K/Akt Pathways to Sensitize Cancer Cells to Therapy -- Histone Deacetylase Inhibitors and Anticancer Activity -- Eicosanoids and Resistance of Cancer Cells to Chemotherapeutic Agents -- Part III. Sensitization via Transcription Factors -- The RKIP and STAT3 Axis in Cancer Chemotherapy: Opposites Attract -- Targeting Transcription Factors with Decoy Oligonucleotides: Modulation of the Expression of Genes Involved in Chemotherapy Resistance of Tumor Cells -- p53 Inhibitors as Cancer Sensitizing Agents -- Nitric Oxide Induced Immunosensitization to Apoptosis by Fas-L and TRAIL -- Natural Agents That Can Sensitize Tumor Cells to Chemotherapy and Radiation Therapy -- Part IV. Sensitization via Targeting Apoptotic Pathways -- Inhibitors of the Bcl-2 Protein Family as Sensitizers to Anticancer Agents -- Therapeutic Targeting of Apoptosis in Cancer -- Peptides and Peptidomimetics as Cancer Therapy Sensitizing Agents -- Non-Peptidic Mimetics as Cancer-Sensitizing Agents -- Sensitization of Cancer Cells to Cancer Therapies by Isoflavone and Its Synthetic Derivatives -- Antisense Oligonucleotides and siRNA as Specific Inhibitors of Gene Expression: Mechanisms of Action and Therapeutic Potential -- Part V. Sensitization Tailored to Individual Patients -- DNA Polymorphisms Affecting Chemosensitivity Toward Drugs -- Pharmacogenetics in Cancer Management: Scenario for Tailored Therapy.
- Format
- e-Book
- Location
- Online
Tumor metabolome targeting and drug development
https://libcat.nshealth.ca/en/permalink/provcat33581
Steven Kanner, editor.
--New York:
Humana Press
, c2014.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Responsibility
- Steven Kanner, editor
- Place of Publication
- New York
- Publisher
- Humana Press
- Date of Publication
- c2014
- Physical Description
- 1 online resource (viii, 198 pages)
- Series Title
- Cancer drug discovery and development
- ISBN
- 9781461495451 (electronic bk.)
- 9781461495444
- Subjects (MeSH)
- Drug Design
- Metabolome
- Neoplasms - metabolism
- Subjects (LCSH)
- Cell metabolism
- Cancer cells - Metabolism
- Cancer cells - Growth
- Contents
- 1. Tumor Cell Metabolic Reprogramming and Drug Targeting -- 2. Cancer Metabolism: A Nexus of Matter, Energy, and Reactive Oxygen Species -- 3. Regulating Mitochondrial Respiration in Cancer -- 4. Regulation of Cancer Cell Metabolism by Hypoxia -- 5. Glucose Metabolism and the Antioxidative Defense System in Cancer Cells: Options for the Application of ROS-based Anticancer Drugs -- 6. Modulating Autophagy and the “Reverse Warburg Effect” -- 7. Metabolic Adaptation in Reprogrammed Cancer Cells -- 8. Targeting of PFKFB3.
- Format
- e-Book
- Location
- Online
