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Bioimaging in neurodegeneration

https://libcat.nshealth.ca/en/permalink/provcat21901
Broderick, Patricia A. --Totowa, NJ: Humana Press , 2005.
Call Number
WL 359 B615 2005
Location
Halifax Infirmary
Call Number
WL 359 B615 2005
Author
Broderick, Patricia A
Other Authors
Rahni, David N
Kolodny, Edwin H
Place of Publication
Totowa, NJ
Publisher
Humana Press
Date of Publication
2005
Physical Description
313 p. + 1 CD-ROM
ISBN
1588293912
Subjects (MeSH)
Neurodegenerative Diseases - diagnosis
Diagnostic Techniques, Neurological
Format
Book
Location
Halifax Infirmary
Loan Period
3 weeks
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End of life care in neurological disease

https://libcat.nshealth.ca/en/permalink/provcat32287
David Oliver, editor. --London: Springer , c2013.
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Location
Online
People with advancing neurological disease face increasing physical symptoms, along with psychosocial and spiritual issues affecting both themselves and their families and carers. There is increasing awareness that the end of life in neurological disease can be anticipated and recognised, taking into account certain key features of disease progression, and the associated issues can be addressed. The individual can prepare for future changes in their health, and be in a stronger position to infl…
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Other Authors
Oliver, David
Responsibility
David Oliver, editor
Place of Publication
London
Publisher
Springer
Date of Publication
c2013
Physical Description
1 online resource (x, 238 p. : 10 ill., 6 ill. in color)
ISBN
9780857296825
Subjects (MeSH)
Neurodegenerative Diseases - therapy
Palliative Care - methods
Terminal Care - methods
Terminally Ill
Subjects (LCSH)
Internal medicine
Neurology
Pain medicine
Abstract
People with advancing neurological disease face increasing physical symptoms, along with psychosocial and spiritual issues affecting both themselves and their families and carers. There is increasing awareness that the end of life in neurological disease can be anticipated and recognised, taking into account certain key features of disease progression, and the associated issues can be addressed. The individual can prepare for future changes in their health, and be in a stronger position to influence or direct the care they receive. End of Life Care in Neurological Disease encourages health and social care professionals to become closely involved in the care of these people and their families, to maintain and maximise quality of life and plan ahead. This book addresses the principles and practice of end of life care for neurological disease, is written with a clinical, multidisciplinary focus, and is enriched with detailed case studies. This book is an accessible text for the multidisciplinary team in specialist palliative care, and will also be of interest to healthcare professionals in neurological services, including neurologists and neurology specialist nurses, rehabilitation services, general practitioners and community nurses. As care professionals, we are in a powerful position to help those who are living with advanced neurological disease and improve their quality of life and death.
Contents
1. End of Life Care -- 2. End of life care in neurological disease -- 3. Communication -- 4. Physical Symptoms Assessment Management -- 5. Holistic Care Psychosocial and Spiritual Aspects -- 6. Coordination of Care -- 7. Advance Care Planning -- 8. Care at the end of life -- 9. Carers -- 10. Future Developments in Care -- 11. International Aspects of Care: Australia -- 12. International Aspects of Care: Europe -- 13. International Aspects of Care: Africa -- 14. Conclusion -- Index.
Format
e-Book
Location
Online
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Mitochondrial Dysfunction in Neurodegenerative Disorders

https://libcat.nshealth.ca/en/permalink/provcat40099
Amy K. Reeve, Eve M. Simcox, Michael R. Duchen, Doug M. Turnbull, editors. (Second edition) --Cham: Springer , c2016.
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Location
Online
This second edition brings together up-to-date contributions from leaders in the field internationally on the various ways in which mitochondrial dysfunction contributes to the pathogenesis of neurodegenerative diseases, including Parkinson's disease, Alzheimer's disease and multiple sclerosis. The reader is guided through the basic functions of mitochondria and the mechanisms that lead to their dysfunction, and on to the consequences of this dysfunction for neuronal function before finishing w…
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Other Authors
Reeve, Amy K
Simcox, Eve M
Duchen, Michael R
Turnbull, Doug M
Responsibility
Amy K. Reeve, Eve M. Simcox, Michael R. Duchen, Doug M. Turnbull, editors
Edition
Second edition
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2016
Physical Description
1 online resource (xi, 380 p. : 34 illus., 29 illus. in color)
ISBN
9783319286372
9783319286358 (print ed.)
Subjects (MeSH)
Mitochondria - metabolism
Mitochondria - pathology
Mitochondrial Diseases - pathology
Nerve Degeneration
Neurodegenerative Diseases - pathology
Abstract
This second edition brings together up-to-date contributions from leaders in the field internationally on the various ways in which mitochondrial dysfunction contributes to the pathogenesis of neurodegenerative diseases, including Parkinson's disease, Alzheimer's disease and multiple sclerosis. The reader is guided through the basic functions of mitochondria and the mechanisms that lead to their dysfunction, and on to the consequences of this dysfunction for neuronal function before finishing with the modelling of these disorders and discussion of new potential therapeutic targets. Additional chapters have been added to the book to reflect advances in the field and there are many new contributors and topics, including how mitochondria are degraded and the interaction of the mitochondria with pathologically relevant proteins. Mitochondrial Dysfunction in Neurodegenerative Disorders provides an accessible, authoritative guide to this important area for neurologists; research and clinical neuroscientists; neuropathologists; and residents with an interest in clinical research.
Contents
Part I. Mitochondria and Neurodegenerative Disease -- An Introduction to Mitochondria, Their Structure and Functions -- Part II. Mitochondrial Dysfunction: Causes and Effects? -- Neurodegeneration in Mitochondrial Disorders -- The Ageing Brain, Mitochondria and Neurodegeneration -- Mitochondrial Genes and Neurodegenerative Disease -- Mitochondrial Signalling and Neurodegeneration -- Part III. Functional Consequences of Mitochondrial Dysfunction -- Life on the Edge: Determinants of Selective Neuronal Vulnerability in Parkinson's Disease -- Mitochondrial Dynamics and Neurodegeneration -- Mitochondrial Dysfunction and Transport in Demyelinating Disease with Inflammation -- Mitochondria, the Synapse, and Neurodegeneration -- Protein Misfolding and Aggregation: Implications for Mitochondrial Dysfunction and Neurodegeneration -- Mitochondrial Degradation, Autophagy and Neurodegenerative Disease -- The Deleterious Duo of Neurodegeneration: Lysosomes and Mitochondria -- Part IV. Measuring the Contribution of Mitochondrial Dysfunction to Neurodegenerative Disease -- Can We Accurately Model Mitochondrial Dysfunction in Neurodegeneration? -- Mitochondrial Function and Dynamics Imaged In Vivo -- Part V. The Future -- Development of Treatments and Therapies to Target Mitochondrial Dysfunction -- Summary and Conclusions.
Format
e-Book
Location
Online
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MRI of degenerative disease of the spine : a case-based atlas

https://libcat.nshealth.ca/en/permalink/provcat34078
Paola D'Aprile ; in collaboration with Alfredo Tarantino. --Cham, Switzerland: Springer , c2015.
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Location
Online
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Author
D'Aprile, Paola
Other Authors
Tarantino, Alfredo
Responsibility
Paola D'Aprile ; in collaboration with Alfredo Tarantino
Place of Publication
Cham, Switzerland
Publisher
Springer
Date of Publication
c2015
Physical Description
1 online resource (xv, 152 pages)
ISBN
9783319094472 (electronic bk.)
9783319094465
Subjects (MeSH)
Magnetic Resonance Imaging - Atlases
Magnetic Resonance Imaging - Case Reports
Neurodegenerative Diseases - diagnosis - Atlases
Neurodegenerative Diseases - diagnosis - Case Reports
Spinal Diseases - diagnosis - atlases
Spinal Diseases - diagnosis - Case Reports
Subjects (LCSH)
Spine - Diseases - Magnetic resonance imaging - Atlases
Contents
Part I. Clinical and Technical Aspects -- 1. Biomechanics of the Spine -- 2. MRI in Degenerative Disease of the Spine -- Part II. Clinical Cases.
Format
e-Book
Location
Online
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Neurodegeneration in Multiple Sclerosis

https://libcat.nshealth.ca/en/permalink/provcat29370
edited by Massimo Filippi, Marco Rovaris, Giancarlo Comi. --Milan: Springer-Verlag Italia , c2007.
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Location
Online
Available Online
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Author
Filippi, Massimo
Other Authors
Rovaris, Marco
Comi, Giancarlo
Responsibility
edited by Massimo Filippi, Marco Rovaris, Giancarlo Comi
Place of Publication
Milan
Publisher
Springer-Verlag Italia
Date of Publication
c2007
Series Title
Topics in Neuroscience
ISBN
9788847003910
Subjects (MeSH)
Multiple Sclerosis - diagnosis
Multiple Sclerosis - physiopathology
Neurodegenerative Diseases - physiopathology
Subjects (LCSH)
Neurosciences
Neurology
Format
e-Book
Location
Online
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Neurodegenerative diseases and metal ions

https://libcat.nshealth.ca/en/permalink/provcat26829
Sigel, Astrid. --Hoboken, NJ: John Wiley & Sons , 2006.
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Location
Online
Available Online
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Author
Sigel, Astrid
Other Authors
Sigel, Helmut
Place of Publication
Hoboken, NJ
Publisher
John Wiley & Sons
Date of Publication
2006
Physical Description
1 online resource (xxiii, 463 p.) : ill.
Series Vol.
v. 1
Series Title
Metal ions in life sciences
ISBN
9780470014882
Subjects (MeSH)
Metals - adverse effects
Metals - metabolism
Neurodegenerative Diseases - chemically induced
Prion Diseases - chemically induced
Protein Folding
Contents
The role of metal ions in neurology: an introduction / Dorothea Strozyk and Ashley I. Bush -- Protein folding, misfolding, and disease / Jennifer C. Lee ... [et al.] -- Metal ion binding properties of proteins related to neurodegeneration / Henryk Kozlowski ... [et al.] -- Metallic prions: mining the core of transmissible spongiform encephalopathies / David R. Brown -- The role of metal ions in the amyloid precursor protein and in Alzheimer's disease / Thomas A. Bayer and Gerd Multhaup -- The role of iron in the pathogenesis of Parkinson's disease / Manfred Gerlach ... [et al.] -- In vivo assessment of iron in Huntington's disease and other age-related neurodegenerative brain diseases / George Bartzokis ... [et al.] -- Copper-zinc superoxide dismutase and familial amyotrophic lateral sclerosis / Lisa J. Whitson and P. John Hart -- The malfunctioning of copper transport in Wilson and Menkes diseases / Bibudhendra Sarkar -- Iron and its role in neurodegenerative diseases / Roberta J. Ward and Robert R. Crichton -- The chemical interplay between catecholamines and metal ions in neurological diseases / Wolfgang Linert ... [et al.] -- Zinc metalloneurochemistry: physiology, pathology, and probes / Christopher J. Chang and Stephen J. Lippard -- The role of aluminum in neurotoxic and neurodegenerative processes / Tamás Kiss, Krisztina Gajda-Schrantz, and Paolo F. Zatta -- Neurotoxicity of cadmium, lead, and mercury / Hana R. Pohl, Henry G. Abadin, and John F. Risher -- Neurodegenerative diseases and metal ions. A concluding overview / Dorothea Strozyk and Ashley I. Bush.
Format
e-Book
Location
Online
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Neurodegenerative Diseases : Clinical Aspects, Molecular Genetics and Biomarkers

https://libcat.nshealth.ca/en/permalink/provcat43105
Daniela Galimberti, Elio Scarpini, editors. (Second edition) --Cham: Springer , c2018.
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Location
Online
This book gives an overview of the current knowledge on the most common neurodegenerative diseases, including Alzheimer's disease, frontotemporal lobar degeneration, Lewy body dementia,Parkinson's disease, amyotrophic lateral sclerosis, and additional less common neurodegenerative diseases. Both clinical and basic aspects of each disease are treated, including novel diagnostic criteria, old and new treatments, basic discoveries (genetics, epigenetics and molecular biology), and translation of b…
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Other Authors
Galimberti, Daniela
Scarpini, Elio
Responsibility
Daniela Galimberti, Elio Scarpini, editors
Edition
Second edition
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2018
Physical Description
1 online resource (x, 407 p.) : 23 illus., 20 illus. in color
ISBN
9783319729381
9783319729374 (print ed.)
9783319729398 (print ed.)
Subjects (MeSH)
Nerve Degeneration
Nervous System Physiological Phenomena
Nervous System - physiopathology
Neurodegenerative Diseases
Specialty
Neurology
Pathology
Abstract
This book gives an overview of the current knowledge on the most common neurodegenerative diseases, including Alzheimer's disease, frontotemporal lobar degeneration, Lewy body dementia,Parkinson's disease, amyotrophic lateral sclerosis, and additional less common neurodegenerative diseases. Both clinical and basic aspects of each disease are treated, including novel diagnostic criteria, old and new treatments, basic discoveries (genetics, epigenetics and molecular biology), and translation of basic research into biomarkers for early diagnosis, particularly to identify peripheral biomarkers. In addition, emerging data indicate that neurodegeneration seems to also be present in classically non-degenerative disorders. Therefore, a chapter about overlapping mechanisms between dementias and psychiatric disorders is included, as well as a description of the role of neurodegeneration in multiple sclerosis. Neurodegenerative Diseases is aimed at clinicians, particularly those working in academic hospitals. This multidisciplinary book will also be of interest to basic researchers in medical fields.
Contents
1. Genetics and epigenetics in the neurodegenerative disorders of the central nervous system -- 2. Diagnosis of Alzheimer's disease typical and atypical forms -- 3. Genetic complexity of early-onset Alzheimer's disease -- 4. Genetic risk factors for complex forms of Alzheimer's disease -- 5. Role of cerebrovascular disease in cognition -- 6. Risk factors and prevention in Alzheimer's disease and dementia -- 7. Diagnosis of frontotemporal dementia -- 8. Autosomal dominant frontotemporal lobar degeneration: from genotype to phenotype -- 9. Genetic risk factors for sporadic frontotemporal dementia -- 10. Alzheimer's disease and frontotemporal lobar degeneration: mouse models -- 11. Fluid biomarkers in Alzheimer's disease and frontotemporal dementia -- 12. Biomarkers for Alzheimer's disease and frontotemporal lobar degeneration: imaging -- 13. Genotypic and phenotypic heterogeneity in Amyotrophic lateral sclerosis -- 14. Lewy body dementia -- 15. Rare dementias -- 16. Neurodevelopmental and neurodegenerative alterations in the pathophysiology of schizophrenia: focus on neuro-immuno-inflammation -- 17. Parkinson's disease: contemporary concepts and clinical management -- 18. Neurodegeneration and multiple sclerosis.
Format
e-Book
Location
Online
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Neurodegenerative diseases : clinical aspects, molecular genetics and biomarkers

https://libcat.nshealth.ca/en/permalink/provcat33732
Daniela Galimberti, Elio Scarpini, editors. --London: Springer , c2014.
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Location
Online
This book gives an overview of the current knowledge on the most common neurodegenerative diseases, including Alzheimer's disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and additional neurodegenerative diseases. Different aspects of each disease are reviewed, including clinical issues, treatments, basic discoveries (genetics and molecular biology), and translation of basic research into biomarkers for early diagnosis. In addition, emerging data indicate that neurodeg…
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Other Authors
Galimberti, Daniela
Scarpini, E
Responsibility
Daniela Galimberti, Elio Scarpini, editors
Place of Publication
London
Publisher
Springer
Date of Publication
c2014
Physical Description
1 online resource (xix, 253 pages)
ISBN
9781447163800 (electronic bk.)
9781447163794
Subjects (MeSH)
Alzheimer Disease
Neurodegenerative Diseases
Biological Markers
Subjects (LCSH)
Nervous system - Degeneration
Neurology
Neurosciences
Abstract
This book gives an overview of the current knowledge on the most common neurodegenerative diseases, including Alzheimer's disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and additional neurodegenerative diseases. Different aspects of each disease are reviewed, including clinical issues, treatments, basic discoveries (genetics and molecular biology), and translation of basic research into biomarkers for early diagnosis. In addition, emerging data indicate that neurodegeneration seems to also be present in classically non-degenerative disorders. Therefore, a chapter about overlapping mechanisms between dementias and psychiatric disorders is included, as well as a description of the role of neurodegeneration in multiple sclerosis. Neurodegenerative Diseases is aimed at clinicians, particularly those working in academic hospitals. This multidisciplinary book will also be of interest to basic researchers in medical fields.
Contents
Genetics and Epigenetics: Basic Concepts -- Alzheimer's Disease: Clinical Aspects and Treatments -- Autosomal Dominant Alzheimer's Disease: Underlying Causes -- Genetic Risk Factors for Alzheimer's Disease -- The Role of Cerebrovascular Disease in Cognitive Decline -- Nongenetic Risk Factors for Alzheimer's Disease -- Nongenetic Risk Factors for Alzheimer's Disease -- Frontotemporal Lobar Degeneration: Genetics and Clinical Phenotypes -- Alzheimer's Disease and Frontotemporal Lobar Degeneration: Mouse Models -- Cerebrospinal Fluid Biomarkers in Alzheimer's Disease and Frontotemporal Dementia -- Biomarkers for Alzheimer's Disease and Frontotemporal Lobar Degeneration: Imaging -- Amyotrophic Lateral Sclerosis: Genotypes and Phenotypes -- Uncommon Dementias -- Neurodevelopment Alterations, Neurodegeneration, and Immunoinflammatory Patterns in the Pathophysiology of Schizophrenia -- Neurodegeneration and Multiple Sclerosis.
Format
e-Book
Location
Online
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Neurodegenerative diseases : integrative PPPM approach as the medicine of the future

https://libcat.nshealth.ca/en/permalink/provcat32642
Silvia Mandel, editor. --Dordrecht: Springer , c2013.
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Location
Online
The economic burden of dementia was estimated as being US$ 604 billion in 2010. Now it is time for new guidelines in handling of neurodegenerative disorders. Optimistic versus Pessimistic Prognosis depends much on diagnostic and treatment approaches which healthcare will preferably adopt in the near future. Current dramatic situation can be significantly improved by the implementation of appropriate early diagnostic, targeted preventive measures and therapies tailored to the person advancing he…
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Other Authors
Mandel, Silvia
Responsibility
Silvia Mandel, editor
Place of Publication
Dordrecht
Publisher
Springer
Date of Publication
c2013
Physical Description
1 online resource (xvii, 396 p. : 39 ill., 32 ill. in color)
Series Vol.
v. 2
Series Title
Advances in predictive, preventive and personalised medicine
ISBN
9789400758667
Subjects (MeSH)
Neurodegenerative Diseases
Neurosciences
Neurology
Subjects (LCSH)
Medicine
Neurosciences
Neurology
Abstract
The economic burden of dementia was estimated as being US$ 604 billion in 2010. Now it is time for new guidelines in handling of neurodegenerative disorders. Optimistic versus Pessimistic Prognosis depends much on diagnostic and treatment approaches which healthcare will preferably adopt in the near future. Current dramatic situation can be significantly improved by the implementation of appropriate early diagnostic, targeted preventive measures and therapies tailored to the person advancing healthcare and enhancing the patient life quality. Neurodegenerative Diseases are pathologies of multi-factorial nature involving interplay of epi/genetic and environmental risk factors. Insights into molecular pathomechanisms will enable to create the most effective neuro-protective strategies and individualised treatment before manifest pathology. Utilization of the advanced integrative medical approach could enable a significant portion of population to reach the 100-year age limit remaining vibrant in excellent physical and mental health as actively contributing members of the society. The crucial role of the integrative approach by PPPM has been acknowledged as priorities by World Health Organization, United Nations and the European Union among others. Extensive efforts of international consortia are essential in the field to consolidate the accumulated expertise and to create population screening, robust diagnostic approaches, effective prevention in groups at high risk and targeted treatments. This book volume "Neurodegenerative Diseases: Integrative PPPM Approach as the Medicine of the Future" is intended to serve as a reference source for basic researchers and healthcare industry involved in the field of neurosciences with a special emphasis on mental health promotion and innovations intended to delay or even prevent neurodegenerative diseases.
Contents
What is this book series about? -- Preface -- Introductory chapter -- Individual predispositions in healthy vasospastic individuals: Patient profiling for targeted prevention of 'down-stream' pathologies as cost-effective personalised medicine -- Idiopathic REM sleep behavior disorder as a long-term predictor of neurodegenerative disorders -- New animal models of progressive neurodegeneration: tools for developing predictive diagnostics and identifying presymptomatic therapeutic targets -- Tau pathology: A selected view on the current status -- The Use of Biomarkers for Prediction and Prevention of Alzheimer's and Parkinson's Diseases -- Making clinical trials of Alzheimer's disease delay-of-onset a reality by use of a prognostic genetic biomarker -- An update on CSF biomarkers of Parkinson's disease -- Glaucomatous optic neuropathy: Risk assessment and potential targets for effective prevention and treatments tailored to the patient -- Toward a personalized approach in amyotrophic lateral sclerosis: new developments in diagnosis, genetics, pathogenesis and therapies -- Recent advances in ALS research: perspectives for personalized clinical application -- Exercise in Multiple Sclerosis – an Integral Component of Disease Management -- Bridging the Informatics Gap between Bench and Bedside: Implications to Neurodegenerative Diseases -- Personalized Medicine In Rare Paediatric Neurometabolic Diseases -- Author Index -- Subject Index.
Format
e-Book
Location
Online
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Neurodegenerative diseases : neurobiology, pathogenesis, and therapeutics

https://libcat.nshealth.ca/en/permalink/provcat27215
[edited by] M. Flint Beal, Anthony E. Lang, Albert C. Ludolph. --Cambridge, UK: Cambridge University Press , c2005.
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Location
Online
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Author
Beal, M. Flint
Other Authors
Lang, Anthony E
Ludolph, Albert C
Responsibility
[edited by] M. Flint Beal, Anthony E. Lang, Albert C. Ludolph
Place of Publication
Cambridge, UK
Publisher
Cambridge University Press
Date of Publication
c2005
Physical Description
xxii, 985 p.
ISBN
6610162689 (electronic bk.)
Subjects (MeSH)
Neurodegenerative Diseases
Contents
Cover -- Half-Title -- Title -- Copyright -- Contents -- Preface -- Contributors -- Part I Basic aspects of neurodegeneration -- 1 Endogenous free radicals and antioxidants in the brain -- Formation of oxygen free radicals -- Low-molecular weight scavengers -- Exogenous -- Antioxidant proteins and enzymes -- Markers of free radical damage -- Cellular and histochemical analyses -- REFERENCES -- 2 Biological oxidants and therapeutic antioxidants -- Introduction -- Why is identification of reactive species and biomolecular targets so difficult? -- 3 Mitochondria, metabolic inhibitors and neurodegeneration -- Mitochondrial energy production and sites of action for metabolic inhibitors -- Mitochondrial calcium homeostasis -- Mitochondrial free radical production -- Mitochondrial permeability transition -- Mitochondria and cell death: necrosis -- Mitochondrial and cell death: apoptosis -- Mitochondrial inhibition and neurodegeneration -- Concluding remarks -- REFERENCES -- 4 Excitotoxicity and excitatory amino acid antagonists in chronic neurodegenerative diseases -- Introduction -- Excitotoxicity and neurodegenerative diseases -- Excitotoxicity and Parkinson's disease -- Huntington's disease -- Glutamate in Alzheimer's disease -- Amyotrophic lateral sclerosis -- Conclusions -- REFERENCES -- 5 Glutamate transporters -- Introduction -- High affinity, Na+-dependent glutamate transporters: localization, functional properties and topology -- Regulation of glutamate transporters -- Excitatory neurotransmission and glutamate transporters -- Excitotoxicity and glutamate transporters -- Neurodegenerative diseases and glutamate transporters -- Concluding remarks -- REFERENCES -- 6 Calcium binding proteins in selective vulnerability of motor neurons -- Introduction -- Increased calcium in motor neurons in ALS -- Cellular calcium homeostasis and calcium binding proteins -- Calcium binding proteins in motor neurons -- AMPA/kainate receptors and selective vulnerability -- Mechanism of protection of motor neurons by calcium binding proteins: axon terminals -- Mechanism of protection of motor neurons by calcium binding proteins: cell bodies -- In vitro transfection study -- In vivo studies -- Stress-related changes of CaBPs in motoneurons and glial cells -- Neuroprotective role of CaBPs in other systems -- Conclusions: calcium-mediated degeneration of motor neurons -- Acknowledgements -- REFERENCES -- 7 Apoptosis in neurodegenerative diseases -- Introduction -- Evidence for apoptosis and caspase activation in human diseases -- Caspase inhibition and inflammation -- Limitations and cautions -- REFERENCES -- 8 Neurotrophic factors -- Introduction -- Developmental motoneuron cell death -- Neurotrophic factors for motoneurons -- Identification of cellular signaling pathways responsible for neurotrophic factor mediated survival of motoneurons -- The role of neuronal activity and glutamate for motoneuron survival -- An active role of NGF signaling in motoneuron cell death? -- Downstream signals which mediate the neuronal survival response to neurotrophins and CNTF: the role of members of the IAP family -- Animal models
Format
e-Book
Location
Online
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Neurodegenerative Disorders : A Clinical Guide

https://libcat.nshealth.ca/en/permalink/provcat39911
Orla Hardiman, Colin P. Doherty, Marwa Elamin, Peter Bede, editors. (Second edition) --Cham: Springer , c2016.
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Location
Online
This new edition provides an accessible guide to the commonest neurodegenerative diseases, outlining the main clinical features, treatment options and outcomes of the conditions most frequently encountered in clinical practice. Beginning with an overview of the general principles that underlie degeneration, and the contribution of established and new diagnostics techniques, the book goes on to describe the most common neurodegenerative conditions and, new for the second edition, also HIV dement…
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Other Authors
Hardiman, Orla
Doherty, Colin P
Elamin, Marwa
Bede, Peter
Responsibility
Orla Hardiman, Colin P. Doherty, Marwa Elamin, Peter Bede, editors
Edition
Second edition
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2016
Physical Description
1 online resource (x, 336 p. : 49 illus., 19 illus. in color)
ISBN
9783319233093
9783319233086 (print ed.)
Subjects (MeSH)
Neurodegenerative Diseases
Abstract
This new edition provides an accessible guide to the commonest neurodegenerative diseases, outlining the main clinical features, treatment options and outcomes of the conditions most frequently encountered in clinical practice. Beginning with an overview of the general principles that underlie degeneration, and the contribution of established and new diagnostics techniques, the book goes on to describe the most common neurodegenerative conditions and, new for the second edition, also HIV dementia and multiple sclerosis. Final chapters cover important management issues including the use of palliative care strategies, biomarkers and neuropsychology. Written by experts in the field internationally Neurodegenerative Disorders, Second Edition is a practical guide for clinicians that will be indispensable for the management of these conditions.
Contents
Common Themes in the Pathogenesis of Neurodegeneration -- Imaging Biomarkers in Neurodegenerative Conditions -- The Role of Neuropsychology Assessment in Neurodegeneration -- Alzheimer's Disease -- Dementia and Cerebrovascular Disease -- Parkinson's Disease -- Fronto-Temporal Dementia (FTD) -- Amyotrophic Lateral Sclerosis -- Huntington's disease -- Parkinsonism-Plus Syndromes -- Medical Mimics of Neurodegenerative Diseases -- Prion Diseases -- Managing Neuropsychiatric Symptoms of Neurodegenerative Diseases -- HIV and Other Infectious Causes of Dementia -- Neuroinflammatory Disorders -- Clinical Trials in Neurodegeneration -- Palliative Care and End of Life Care.
Format
e-Book
Location
Online
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Neuropsychiatric Disorders

https://libcat.nshealth.ca/en/permalink/provcat29917
edited by Koho Miyoshi, Yasushi Morimura, Kiyoshi Maeda. --Tokyo: Springer Japan , c2010.
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Location
Online
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Author
Miyoshi, Koho
Other Authors
Morimura, Yasushi
Maeda, Kiyoshi
Responsibility
edited by Koho Miyoshi, Yasushi Morimura, Kiyoshi Maeda
Place of Publication
Tokyo
Publisher
Springer Japan
Date of Publication
c2010
ISBN
9784431538714
Subjects (MeSH)
Brain Diseases
Mental Disorders
Neurodegenerative Diseases
Neuropsychology
Subjects (LCSH)
Neurology
Psychiatry
Format
e-Book
Location
Online
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Oxidative stress and neurodegenerative disorders

https://libcat.nshealth.ca/en/permalink/provcat27608
Qureshi, G. Ali. --Amsterdam, Netherlands: Elsevier , 2007.
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Location
Online
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Author
Qureshi, G. Ali
Other Authors
Parvez, S. Hassan
Place of Publication
Amsterdam, Netherlands
Publisher
Elsevier
Date of Publication
2007
Physical Description
772 p.
ISBN
9780444528094
Subjects (MeSH)
Oxidative Stress
Neurodegenerative Diseases - physiopathology
Format
e-Book
Location
Online
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PET in the evaluation of Alzheimer's disease and related disorders

https://libcat.nshealth.ca/en/permalink/provcat23504
Silverman, Daniel HS. --New York, NY: Springer , 2009.
Call Number
WT 155 P477 2009
Location
Halifax Infirmary
Call Number
WT 155 P477 2009
Author
Silverman, Daniel HS
Place of Publication
New York, NY
Publisher
Springer
Date of Publication
2009
Physical Description
215 p.
ISBN
9780387764191
Subjects (MeSH)
Positron-Emission Tomography - methods
Alzheimer Disease - diagnosis
Neurodegenerative Diseases - diagnosis
Brain - diagnostic imaging
Radionuclide Imaging
Format
Book
Location
Halifax Infirmary
Loan Period
3 weeks
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Urological Care for Patients with Progressive Neurological Conditions

https://libcat.nshealth.ca/en/permalink/provcat44922
John T. Stoffel, Elizabeth V. Dray, editors. --Cham: Springer , c2020.
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Location
Online
This text creates a framework for the integration of urological care into the long-term management of patients with progressive neurological conditions. It begins with a general review of the neuroanatomy and physiology of the bladder, followed by a discussion of common techniques for evaluating bladder and upper tract function, and the general principles of bladder management in patients with neurogenic bladder disease. Section II narrows the scope of each chapter to focus on specific neurolog…
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Other Authors
Stoffel, John T.
Dray, Elizabeth V.
Responsibility
John T. Stoffel, Elizabeth V. Dray, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2020
Physical Description
1 online resource (xi, 191 p.) : 39 illus., 26 illus. in color
ISBN
9783030232771
9783030232764 (Print ed.)
9783030232788 (Print ed.)
9783030232795 (Print ed.)
Subjects (MeSH)
Neurodegenerative Diseases - complications
Patient Care Planning
Urinary Bladder, Neurogenic
Specialty
Neurology
Urology
Abstract
This text creates a framework for the integration of urological care into the long-term management of patients with progressive neurological conditions. It begins with a general review of the neuroanatomy and physiology of the bladder, followed by a discussion of common techniques for evaluating bladder and upper tract function, and the general principles of bladder management in patients with neurogenic bladder disease. Section II narrows the scope of each chapter to focus on specific neurological disorders such as Parkinson's Disease, Alzheimer's Disease, Dementia, and Cerebral Palsy. Each chapter begins with a brief synopsis of the neurologic basis of each disease, followed by its most common urologic manifestations, specific recommendations for urologic care in each disease state, and finally a recommended pathway for integrated long-term care of these patients based on available evidence and expert opinion. The final section of the text reviews the generalized care of patients with advanced disease, including palliative and end of life options, focusing on urologic interventions. Urological Care for Patients with Progressive Neurological Conditions will be an invaluable resource for urologists, neurologists, and all health care providers treating patients with neurological diseases.
Contents
Introduction -- Basic Bladder Physiology, Anatomy, Common Urologic Terms -- Neuroanatomy -- Measuring QOL in Degenerative Conditions -- Urodynamic Studies -- Urologic Imaging -- Common Bladder Management Strategies for Patients with Neurogenic Bladder Disease -- Parkinson's Disease and Multisystem Atrophy -- Alzheimer's Disease/Lewy Body Dementia -- Cerebral Palsy -- Huntington's Chorea -- MS and Other Demyelinating Disorders -- ALS -- Friedrich's Ataxia -- Spinal Muscle Atrophy -- Lambert Eaton -- Diabetes -- Care for Patients with Limited Mobility -- Goals and Limits of Care.
Format
e-Book
Location
Online
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